MCID: PHN016
MIFTS: 24

Phenytoin Allergy

Categories: Immune diseases

Aliases & Classifications for Phenytoin Allergy

MalaCards integrated aliases for Phenytoin Allergy:

Name: Phenytoin Allergy 12 15
Dilantin Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040012
SNOMED-CT 67 293869004
UMLS 71 C0570789

Summaries for Phenytoin Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger phenytoin.

MalaCards based summary : Phenytoin Allergy, also known as dilantin allergy, is related to cephalosporin allergy and ceftazidime allergy. An important gene associated with Phenytoin Allergy is TBXA2R (Thromboxane A2 Receptor), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system.

Related Diseases for Phenytoin Allergy

Diseases related to Phenytoin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 cephalosporin allergy 10.4 GNLY CMA1
2 ceftazidime allergy 10.3 GNLY CD4
3 abacavir allergy 10.2 CYP2C9 CD4
4 thiopental allergy 10.2 KNG1 CMA1
5 algoneurodystrophy 10.2 PTGS1 KNG1
6 hypopyon 10.2 HLA-B CD4
7 esophageal candidiasis 10.2 CYP2C9 CD4
8 whipple disease 10.1 IL16 CD4
9 vasomotor rhinitis 10.1 KNG1 IL16 CMA1
10 folliculitis 10.1 GNLY CD4 CCL11
11 leprosy 3 10.1 HLA-B GNLY CD4
12 anal margin carcinoma 10.1 PRF1 CD4
13 carbapenem allergy 10.1 SYK STAT6 GZMB
14 co-trimoxazole allergy 10.1 SYK STAT6 GZMB
15 parasitic helminthiasis infectious disease 10.0 STAT6 CD4 CCL11
16 purulent endophthalmitis 10.0 PRF1 CD4
17 baylisascariasis 10.0 PTGS1 NR1I2
18 oxirane allergy 10.0 KNG1 IL3
19 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.0 IL3 CD4
20 systemic onset juvenile idiopathic arthritis 10.0 PRF1 GZMB
21 lethal midline granuloma 10.0 PRF1 GZMB
22 proteasome-associated autoinflammatory syndrome 1 10.0 PTGS1 CCL3 CCL11
23 esophagitis, eosinophilic, 1 10.0 STAT6 IL3 CCL11
24 nasal cavity lymphoma 10.0 PRF1 GZMB
25 whiplash 10.0 KNG1 IL16 CCL3
26 chronic meningitis 10.0 CD4 CCL11
27 oral tuberculosis 10.0 PRF1 GNLY CD4
28 subcutaneous mycosis 10.0 SYK IL3 CD4
29 stachybotrys chartarum 10.0 IL3 CCL3
30 acute apical periodontitis 10.0 KNG1 IL3
31 loiasis 10.0 CD4 CCL3 CCL11
32 trichinosis 10.0 IL3 CD4 CCL11
33 allergic rhinitis 9.9 TBXA2R KNG1 IL16 CCL11
34 nasal cavity disease 9.9 IL3 CD4 CCL11
35 nose disease 9.9 IL3 CD4 CCL11
36 intrinsic asthma 9.9 IL3 CD4
37 lymphocytic gastritis 9.9 GZMB FASLG
38 exanthem 9.9
39 mast cell neoplasm 9.9 PRF1 IL3 CMA1
40 leukocyte disease 9.9 IL3 CD4 CCL11
41 erythema multiforme 9.8 GZMB GNLY FASLG
42 hemophagocytic lymphohistiocytosis 9.8 PRF1 GZMB GNLY
43 primary biliary cholangitis 9.8 NR1I2 GZMB CD4 CCL11
44 lymphoma, hodgkin, classic 9.8 STAT6 IL3 GZMB
45 acquired immunodeficiency syndrome 9.8 HLA-B CD4 CCL3
46 immunodeficiency 65 9.8 PRF1 FASLG
47 bronchial disease 9.8 STAT6 IL3 CD4 CCL11
48 graft-versus-host disease 9.8 HLA-B GZMB FASLG
49 dermatitis 9.8 IL16 GZMB CMA1 CD4 CCL11
50 viral infectious disease 9.7 HLA-B GZMB CD4 CCL3

Graphical network of the top 20 diseases related to Phenytoin Allergy:



Diseases related to Phenytoin Allergy

Symptoms & Phenotypes for Phenytoin Allergy

Drugs & Therapeutics for Phenytoin Allergy

Search Clinical Trials , NIH Clinical Center for Phenytoin Allergy

Genetic Tests for Phenytoin Allergy

Anatomical Context for Phenytoin Allergy

Publications for Phenytoin Allergy

Articles related to Phenytoin Allergy:

# Title Authors PMID Year
1
Spontaneous complete regression of hypothalamic pilocytic astrocytoma after partial resection in a child, complicated with Stevens-Johnson syndrome: a case report and literature review. 61
26662551 2016
2
Phenytoin hypersensitivity syndrome with positive patch test. A possible cross-reactivity with amitriptyline. 61
9684195 1998
3
Allergic reactions to phenytoin in a general hospital in Singapore. 61
9177818 1996
4
Seasonal incidence of phenytoin allergy unrelated to plasma levels. 61
3977636 1985

Variations for Phenytoin Allergy

Expression for Phenytoin Allergy

Search GEO for disease gene expression data for Phenytoin Allergy.

Pathways for Phenytoin Allergy

Pathways related to Phenytoin Allergy according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 SYK STAT6 IL3 IL16 FASLG CD4
2
Show member pathways
13.08 SYK STAT6 IL3 IL16 HLA-B FASLG
3
Show member pathways
12.74 SYK HLA-B FASLG CD4 CCL3
4 12.25 SYK STAT6 PTGS1 IL3 GZMB FASLG
5
Show member pathways
12.11 SYK PRF1 IL3 HLA-B GZMB FASLG
6
Show member pathways
11.97 PRF1 IL3 HLA-B GZMB GNLY FASLG
7 11.84 TBXA2R SYK PTGS1
8 11.79 STAT6 FASLG CCL11
9 11.59 GZMB CD4 CCL3
10 11.47 CMA1 CCL3 CCL11
11
Show member pathways
11.44 PRF1 GZMB FASLG
12
Show member pathways
11.41 STAT6 GZMB FASLG CD4 CCL3
13 11.34 TBXA2R PTGS1 CYP2C9
14 11.27 STAT6 CD4 CCL11
15
Show member pathways
11.1 GZMB FASLG CCL3
16 10.83 IL3 IL16 FASLG CCL3 CCL11
17 10.71 PTGS1 NR1I2

GO Terms for Phenytoin Allergy

Cellular components related to Phenytoin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 KNG1 IL3 IL16 GNLY FASLG CMA1
2 extracellular region GO:0005576 9.32 PRF1 KNG1 IL3 IL16 GZMB GNLY
3 cytolytic granule GO:0044194 8.96 PRF1 GNLY

Biological processes related to Phenytoin Allergy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.1 TBXA2R STAT6 NR1I2 IL16 FASLG CD4
2 xenobiotic metabolic process GO:0006805 9.65 PTGS1 NR1I2 CYP2C9
3 inflammatory response GO:0006954 9.65 TBXA2R PTGS1 KNG1 CCL3 CCL11
4 cellular response to interferon-gamma GO:0071346 9.63 FASLG CCL3 CCL11
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 SYK IL3 CD4
6 neutrophil chemotaxis GO:0030593 9.58 SYK CCL3 CCL11
7 eosinophil chemotaxis GO:0048245 9.51 CCL3 CCL11
8 immune response GO:0006955 9.5 IL3 IL16 HLA-B FASLG CD4 CCL3
9 enzyme linked receptor protein signaling pathway GO:0007167 9.37 SYK CD4
10 positive regulation of calcium-mediated signaling GO:0050850 9.33 SYK CD4 CCL3
11 positive regulation of killing of cells of other organism GO:0051712 9.32 SYK PRF1
12 cytokine-mediated signaling pathway GO:0019221 9.17 STAT6 IL3 IL16 FASLG CD4 CCL3

Molecular functions related to Phenytoin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 SYK KNG1 HLA-B FASLG CD4
2 cytokine activity GO:0005125 9.02 IL3 IL16 FASLG CCL3 CCL11

Sources for Phenytoin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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