MCID: PHN012
MIFTS: 18

Phenytoin or Carbamazepine Toxicity

Categories: Rare diseases

Aliases & Classifications for Phenytoin or Carbamazepine Toxicity

MalaCards integrated aliases for Phenytoin or Carbamazepine Toxicity:

Name: Phenytoin or Carbamazepine Toxicity 59

Classifications:



External Ids:

Orphanet 59 ORPHA414750

Summaries for Phenytoin or Carbamazepine Toxicity

Related Diseases for Phenytoin or Carbamazepine Toxicity

Graphical network of the top 20 diseases related to Phenytoin or Carbamazepine Toxicity:



Diseases related to Phenytoin or Carbamazepine Toxicity

Symptoms & Phenotypes for Phenytoin or Carbamazepine Toxicity

GenomeRNAi Phenotypes related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.53 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.53 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.53 HLA-B HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.53 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.53 HLA-B HLA-A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.53 HLA-B HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.53 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.53 HLA-B HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.53 HLA-B HLA-A

Drugs & Therapeutics for Phenytoin or Carbamazepine Toxicity

Search Clinical Trials , NIH Clinical Center for Phenytoin or Carbamazepine Toxicity

Genetic Tests for Phenytoin or Carbamazepine Toxicity

Anatomical Context for Phenytoin or Carbamazepine Toxicity

Publications for Phenytoin or Carbamazepine Toxicity

Variations for Phenytoin or Carbamazepine Toxicity

Expression for Phenytoin or Carbamazepine Toxicity

Search GEO for disease gene expression data for Phenytoin or Carbamazepine Toxicity.

Pathways for Phenytoin or Carbamazepine Toxicity

Pathways related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 HLA-A HLA-B
2
Show member pathways
12.24 HLA-A HLA-B
3
Show member pathways
12.11 HLA-A HLA-B
4
Show member pathways
12.05 HLA-A HLA-B
5
Show member pathways
12.02 HLA-A HLA-B
6
Show member pathways
11.97 HLA-A HLA-B
7
Show member pathways
11.92 HLA-A HLA-B
8 11.86 HLA-A HLA-B
9 11.82 HLA-A HLA-B
10 11.71 HLA-A HLA-B
11 11.67 HLA-A HLA-B
12 11.53 HLA-A HLA-B
13 11.44 HLA-A HLA-B
14 11.31 HLA-A HLA-B
15 11.09 HLA-A HLA-B
16 10.02 HLA-A HLA-B

GO Terms for Phenytoin or Carbamazepine Toxicity

Cellular components related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome membrane GO:0031901 9.37 HLA-A HLA-B
2 recycling endosome membrane GO:0055038 9.32 HLA-A HLA-B
3 phagocytic vesicle membrane GO:0030670 9.26 HLA-A HLA-B
4 ER to Golgi transport vesicle membrane GO:0012507 9.16 HLA-A HLA-B
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-A HLA-B
6 MHC class I protein complex GO:0042612 8.62 HLA-A HLA-B

Biological processes related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.49 HLA-A HLA-B
2 immune response GO:0006955 9.48 HLA-A HLA-B
3 viral process GO:0016032 9.46 HLA-A HLA-B
4 regulation of immune response GO:0050776 9.43 HLA-A HLA-B
5 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.4 HLA-A HLA-B
6 interferon-gamma-mediated signaling pathway GO:0060333 9.37 HLA-A HLA-B
7 type I interferon signaling pathway GO:0060337 9.32 HLA-A HLA-B
8 antigen processing and presentation GO:0019882 9.26 HLA-A HLA-B
9 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.16 HLA-A HLA-B
10 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.96 HLA-A HLA-B
11 protection from natural killer cell mediated cytotoxicity GO:0042270 8.62 HLA-A HLA-B

Molecular functions related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.96 HLA-A HLA-B
2 peptide antigen binding GO:0042605 8.62 HLA-A HLA-B

Sources for Phenytoin or Carbamazepine Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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