MCID: PHN012
MIFTS: 20

Phenytoin or Carbamazepine Toxicity

Categories: Rare diseases

Aliases & Classifications for Phenytoin or Carbamazepine Toxicity

MalaCards integrated aliases for Phenytoin or Carbamazepine Toxicity:

Name: Phenytoin or Carbamazepine Toxicity 59

Classifications:



External Ids:

Orphanet 59 ORPHA414750

Summaries for Phenytoin or Carbamazepine Toxicity

MalaCards based summary : Phenytoin or Carbamazepine Toxicity is related to postherpetic neuralgia and atrial tachyarrhythmia with short pr interval. Among its related pathways/superpathways are Influenza A and Interferon gamma signaling. Affiliated tissues include lung and tongue, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Phenytoin or Carbamazepine Toxicity

Diseases related to Phenytoin or Carbamazepine Toxicity via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 postherpetic neuralgia 9.9 HLA-A HLA-B
2 atrial tachyarrhythmia with short pr interval 9.9 HLA-A HLA-B
3 pars planitis 9.9 HLA-A HLA-B
4 pityriasis rosea 9.9 HLA-A HLA-B
5 anterior uveitis 9.9 HLA-A HLA-B
6 chronic pyelonephritis 9.9 HLA-A HLA-B
7 human herpesvirus 8 9.9 HLA-A HLA-B
8 nontuberculous mycobacterial lung disease 9.9 HLA-A HLA-B
9 idiopathic bronchiectasis 9.9 HLA-A HLA-B
10 histoplasmosis 9.9 HLA-A HLA-B
11 pure red-cell aplasia 9.9 HLA-A HLA-B
12 cytomegalovirus retinitis 9.9 HLA-A HLA-B
13 alveolar echinococcosis 9.9 HLA-A HLA-B
14 hematopoietic stem cell transplantation 9.9 HLA-A HLA-B
15 glaucomatocyclitic crisis 9.9 HLA-A HLA-B
16 geographic tongue 9.9 HLA-A HLA-B
17 separation anxiety disorder 9.9 HLA-A HLA-B
18 panuveitis 9.9 HLA-A HLA-B
19 stevens-johnson syndrome/toxic epidermal necrolysis 9.9 HLA-A HLA-B
20 aphthous stomatitis 9.9 HLA-A HLA-B
21 paraneoplastic pemphigus 9.9 HLA-A HLA-B
22 herpes zoster 9.9 HLA-A HLA-B
23 dengue hemorrhagic fever 9.9 HLA-A HLA-B
24 spondyloarthropathy 9.9 HLA-A HLA-B
25 vogt-koyanagi-harada disease 9.9 HLA-A HLA-B
26 severe cutaneous adverse reaction 9.9 HLA-A HLA-B
27 rubella 9.9 HLA-A HLA-B
28 takayasu arteritis 9.9 HLA-A HLA-B
29 cytomegalovirus infection 9.9 HLA-A HLA-B
30 graft-versus-host disease 9.8 HLA-A HLA-B
31 melanoma, uveal 9.8 HLA-A HLA-B
32 behcet syndrome 9.8 HLA-A HLA-B
33 aplastic anemia 9.8 HLA-A HLA-B
34 nasopharyngeal carcinoma 9.8 HLA-A HLA-B
35 human immunodeficiency virus type 1 9.7 HLA-A HLA-B

Graphical network of the top 20 diseases related to Phenytoin or Carbamazepine Toxicity:



Diseases related to Phenytoin or Carbamazepine Toxicity

Symptoms & Phenotypes for Phenytoin or Carbamazepine Toxicity

GenomeRNAi Phenotypes related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.53 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.53 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.53 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.53 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.53 HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.53 HLA-A HLA-B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.53 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.53 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.53 HLA-A HLA-B

Drugs & Therapeutics for Phenytoin or Carbamazepine Toxicity

Search Clinical Trials , NIH Clinical Center for Phenytoin or Carbamazepine Toxicity

Genetic Tests for Phenytoin or Carbamazepine Toxicity

Anatomical Context for Phenytoin or Carbamazepine Toxicity

MalaCards organs/tissues related to Phenytoin or Carbamazepine Toxicity:

41
Lung, Tongue

Publications for Phenytoin or Carbamazepine Toxicity

Variations for Phenytoin or Carbamazepine Toxicity

Expression for Phenytoin or Carbamazepine Toxicity

Search GEO for disease gene expression data for Phenytoin or Carbamazepine Toxicity.

Pathways for Phenytoin or Carbamazepine Toxicity

Pathways related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 HLA-A HLA-B
2
Show member pathways
12 HLA-A HLA-B
3
Show member pathways
11.97 HLA-A HLA-B
4
Show member pathways
11.92 HLA-A HLA-B
5 11.86 HLA-A HLA-B
6 11.82 HLA-A HLA-B
7
Show member pathways
11.73 HLA-A HLA-B
8 11.71 HLA-A HLA-B
9 11.67 HLA-A HLA-B
10 11.53 HLA-A HLA-B
11 11.44 HLA-A HLA-B
12 11.31 HLA-A HLA-B
13 11.09 HLA-A HLA-B
14 10.02 HLA-A HLA-B

GO Terms for Phenytoin or Carbamazepine Toxicity

Cellular components related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome membrane GO:0031901 9.37 HLA-A HLA-B
2 recycling endosome membrane GO:0055038 9.32 HLA-A HLA-B
3 phagocytic vesicle membrane GO:0030670 9.26 HLA-A HLA-B
4 ER to Golgi transport vesicle membrane GO:0012507 9.16 HLA-A HLA-B
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-A HLA-B
6 MHC class I protein complex GO:0042612 8.62 HLA-A HLA-B

Biological processes related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.49 HLA-A HLA-B
2 regulation of immune response GO:0050776 9.48 HLA-A HLA-B
3 interferon-gamma-mediated signaling pathway GO:0060333 9.46 HLA-A HLA-B
4 type I interferon signaling pathway GO:0060337 9.43 HLA-A HLA-B
5 antigen processing and presentation GO:0019882 9.4 HLA-A HLA-B
6 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.37 HLA-A HLA-B
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.32 HLA-A HLA-B
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.26 HLA-A HLA-B
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.16 HLA-A HLA-B
10 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 8.96 HLA-A HLA-B
11 protection from natural killer cell mediated cytotoxicity GO:0042270 8.62 HLA-A HLA-B

Molecular functions related to Phenytoin or Carbamazepine Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.96 HLA-A HLA-B
2 peptide antigen binding GO:0042605 8.62 HLA-A HLA-B

Sources for Phenytoin or Carbamazepine Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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