Aliases & Classifications for Phenytoin Toxicity

MalaCards integrated aliases for Phenytoin Toxicity:

Name: Phenytoin Toxicity 58 30
Arene Oxide Detoxification Defect 58 74
Diphenylhydantoin, Defect in Hydroxylation of 58

External Ids:

OMIM 58 617955
MedGen 43 C0149969
UMLS 74 C1851507

Summaries for Phenytoin Toxicity

MalaCards based summary : Phenytoin Toxicity, also known as arene oxide detoxification defect, is related to encephalopathy and koro. An important gene associated with Phenytoin Toxicity is ALB (Albumin), and among its related pathways/superpathways are Metabolism and Drug metabolism - cytochrome P450. The drugs Phenytoin and Charcoal have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lung and brain.

Description from OMIM: 617955

Related Diseases for Phenytoin Toxicity

Graphical network of the top 20 diseases related to Phenytoin Toxicity:



Diseases related to Phenytoin Toxicity

Symptoms & Phenotypes for Phenytoin Toxicity

Clinical features from OMIM:

617955

Drugs & Therapeutics for Phenytoin Toxicity

Drugs for Phenytoin Toxicity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Not Applicable 57-41-0 1775
2 Charcoal Not Applicable
3 Antidotes Not Applicable
4 Sodium Channel Blockers Not Applicable
5 Diuretics, Potassium Sparing Not Applicable
6 Anticonvulsants Not Applicable
7 Protective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phenytoin and Multidose Activated Charcoal Completed NCT00823264 Not Applicable Activated Charcoal

Search NIH Clinical Center for Phenytoin Toxicity

Genetic Tests for Phenytoin Toxicity

Genetic tests related to Phenytoin Toxicity:

# Genetic test Affiliating Genes
1 Phenytoin Toxicity 30

Anatomical Context for Phenytoin Toxicity

MalaCards organs/tissues related to Phenytoin Toxicity:

42
Thyroid, Lung, Brain

Publications for Phenytoin Toxicity

Articles related to Phenytoin Toxicity:

(show top 50) (show all 105)
# Title Authors Year
1
Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction. ( 30697501 )
2018
2
Unexplained encephalopathy with phenytoin toxicity - hyperammonemia, the underlying cause. ( 30504595 )
2018
3
Phenytoin Toxicity. ( 28632869 )
2017
4
Phenytoin toxicity in two-month-old Thai infant with CYP2C9 gene polymorphism--A case report. ( 25998968 )
2016
5
Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity? ( 27076716 )
2016
6
NAT2 gene polymorphism: covert drug interaction causing phenytoin toxicity. ( 27487996 )
2016
7
Inappropriate utilization of the Sheiner-Tozer equation to determine phenytoin toxicity. ( 25661096 )
2015
8
Psychosis as Harbinger of Phenytoin Toxicity. ( 26862279 )
2015
9
Neurological manifestation of phenytoin toxicity, resulting from drug interaction with chloramphenicol: a case report. ( 29144066 )
2015
10
Fluoxetine-induced phenytoin toxicity: a clinical reminder about the perils of polypharmacy. ( 26411853 )
2015
11
Use of multi-dose activated charcoal in phenytoin toxicity secondary to genetic polymorphism. ( 25597548 )
2015
12
Free phenytoin toxicity. ( 24768668 )
2014
13
Phenytoin toxicity unlikely to result in arrhythmias. ( 24394934 )
2014
14
Phenytoin toxicity unlikely to result in arrhythmias--reply. ( 24394935 )
2014
15
Activated Charcoal Does Not Reduce Duration of Phenytoin Toxicity in Hospitalized Patients. ( 24621645 )
2014
16
Oral phenytoin toxicity causing sinus arrest: a case report. ( 25343048 )
2014
17
Phenytoin toxicity in patients with traumatic brain injury. ( 25033851 )
2014
18
Phenytoin toxicity from cocaine adulteration. ( 24672596 )
2014
19
Ocular motor abnormalities in a patient with phenytoin toxicity--case report and minireview. ( 25459255 )
2014
20
Myristicin and phenytoin toxicity in an infant. ( 24903724 )
2014
21
When less is more: a case of phenytoin toxicity. ( 23536644 )
2013
22
Association of CYP2C9 polymorphisms with phenytoin toxicity in Indian patients. ( 23287317 )
2012
23
Possible long-acting risperidone-induced hypothermia precipitating phenytoin toxicity in an elderly patient. ( 21545623 )
2011
24
Phenytoin toxicity in a patient receiving concomitant use of phenytoin and S-1 plus cisplatin chemotherapy for advanced gastric cancer. ( 21677496 )
2011
25
A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. ( 21338443 )
2011
26
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study. ( 21395647 )
2011
27
Phenytoin toxicity presenting as acute meningo-encephalitis in children. ( 21339662 )
2011
28
Phenytoin toxicity in a patient receiving 5-fluorouracil-based chemotherapy for metastatic colorectal cancer. ( 22184487 )
2011
29
Phenytoin toxicity secondary to an oxcarbazepine-phenytoin 2C19 interaction. ( 21051688 )
2010
30
CYP2C9, CYP2C19, and ABCB1 genotype and hospitalization for phenytoin toxicity. ( 19617466 )
2009
31
Phenytoin toxicity and thyroid dysfunction. ( 19851414 )
2009
32
Phenytoin toxicity masquerading as motor neurone disease. ( 19302663 )
2009
33
Phenytoin toxicity due to genetic polymorphism. ( 19030785 )
2009
34
Phenytoin toxicity: an easily missed cause of cerebellar syndrome. ( 18315788 )
2008
35
Acenocoumarol and phenytoin toxicity in the presence of CYP2C9 mutation. ( 18702389 )
2008
36
Elevated thyroid-stimulating hormone in a 65-year-old patient with phenytoin toxicity. ( 19032007 )
2008
37
Significant drug interaction: phenytoin toxicity due to erlotinib. ( 17383767 )
2007
38
Management of phenytoin toxicity in palliative care. ( 17169967 )
2007
39
Neuropsychiatric manifestations of phenytoin toxicity in an elderly patient. ( 17242593 )
2007
40
Severe phenytoin toxicity in a CYP2C9*3*3 homozygous mutant from India. ( 18040121 )
2007
41
A case of phenytoin toxicity in a patient with advanced lung cancer. ( 16875121 )
2006
42
Unusual presentation of iatrogenic phenytoin toxicity in a newborn. ( 18072100 )
2005
43
A junctional rhythm with retrograde conduction and bradycardia as a dysrhythmia caused by oral phenytoin toxicity. ( 15803967 )
2004
44
Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS). ( 12558586 )
2003
45
Hypothermia and phenytoin toxicity. ( 12897633 )
2003
46
Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports. ( 12915866 )
2003
47
ECG features of sodium channel blockade in rodent phenytoin toxicity and effect of hypertonic saline. ( 14513895 )
2003
48
Noncompliance leading to drug accumulation resulting in phenytoin toxicity. ( 14717477 )
2003
49
Paroxysmal dyskinesia in phenytoin toxicity. ( 12583484 )
2002
50
Phenytoin toxicity with mandibular tremor secondary to intravenous administration. ( 11837377 )
2002

Variations for Phenytoin Toxicity

Expression for Phenytoin Toxicity

Search GEO for disease gene expression data for Phenytoin Toxicity.

Pathways for Phenytoin Toxicity

Pathways related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 ABCB1 ALB CYP2C19 CYP2C9 NAT2 VKORC1
2
Show member pathways
12.44 CYP2C19 CYP2C9 NAT2
3
Show member pathways
11.78 CYP2C19 CYP2C9
4
Show member pathways
11.63 CYP2C19 CYP2C9
5 11.61 CYP2C19 CYP2C9
6
Show member pathways
11.55 ABCB1 CYP2C19 CYP2C9
7
Show member pathways
11.32 ABCB1 CYP2C19 CYP2C9
8
Show member pathways
11.26 CYP2C19 CYP2C9
9 11.22 CYP2C19 CYP2C9
10
Show member pathways
11.18 ABCB1 CYP2C19 CYP2C9
11
Show member pathways
11.09 CYP2C19 CYP2C9
12 11.02 ABCB1 CYP2C9
13
Show member pathways
10.94 ABCB1 CYP2C19 CYP2C9
14
Show member pathways
10.86 CYP2C9 NAT2
15
Show member pathways
10.78 ABCB1 CYP2C9
16 10.67 ABCB1 CYP2C9
17 10.3 ABCB1 CYP2C19 CYP2C9

GO Terms for Phenytoin Toxicity

Cellular components related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.16 CYP2C19 CYP2C9
2 organelle membrane GO:0031090 8.96 CYP2C19 CYP2C9
3 endoplasmic reticulum GO:0005783 8.92 ALB CYP2C19 CYP2C9 VKORC1

Biological processes related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.63 CYP2C19 CYP2C9 VKORC1
2 steroid metabolic process GO:0008202 9.43 CYP2C19 CYP2C9
3 exogenous drug catabolic process GO:0042738 9.4 CYP2C19 CYP2C9
4 organic acid metabolic process GO:0006082 9.37 CYP2C19 CYP2C9
5 xenobiotic metabolic process GO:0006805 9.33 CYP2C19 CYP2C9 NAT2
6 epoxygenase P450 pathway GO:0019373 9.32 CYP2C19 CYP2C9
7 omega-hydroxylase P450 pathway GO:0097267 9.26 CYP2C19 CYP2C9
8 monoterpenoid metabolic process GO:0016098 8.96 CYP2C19 CYP2C9
9 drug metabolic process GO:0017144 8.8 CYP2C19 CYP2C9 VKORC1

Molecular functions related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.61 CYP2C19 CYP2C9 VKORC1
2 heme binding GO:0020037 9.48 CYP2C19 CYP2C9
3 iron ion binding GO:0005506 9.46 CYP2C19 CYP2C9
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.4 CYP2C19 CYP2C9
5 drug binding GO:0008144 9.37 ALB CYP2C9
6 monooxygenase activity GO:0004497 9.32 CYP2C19 CYP2C9
7 oxygen binding GO:0019825 9.26 ALB CYP2C19
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP2C19 CYP2C9
9 steroid hydroxylase activity GO:0008395 8.96 CYP2C19 CYP2C9
10 arachidonic acid epoxygenase activity GO:0008392 8.62 CYP2C19 CYP2C9

Sources for Phenytoin Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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