Aliases & Classifications for Phenytoin Toxicity

MalaCards integrated aliases for Phenytoin Toxicity:

Name: Phenytoin Toxicity 57
Arene Oxide Detoxification Defect 57 73
Diphenylhydantoin, Defect in Hydroxylation of 57

External Ids:

OMIM 57 617955
UMLS 73 C1851507

Summaries for Phenytoin Toxicity

MalaCards based summary : Phenytoin Toxicity, also known as arene oxide detoxification defect, is related to koro and paralytic ileus. An important gene associated with Phenytoin Toxicity is ALB (Albumin), and among its related pathways/superpathways are Metabolism and Drug metabolism - cytochrome P450. The drugs Phenytoin and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include thyroid and brain.

Description from OMIM: 617955

Related Diseases for Phenytoin Toxicity

Graphical network of the top 20 diseases related to Phenytoin Toxicity:



Diseases related to Phenytoin Toxicity

Symptoms & Phenotypes for Phenytoin Toxicity

Clinical features from OMIM:

617955

Drugs & Therapeutics for Phenytoin Toxicity

Drugs for Phenytoin Toxicity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Not Applicable 57-41-0 1775
2 Anticonvulsants Not Applicable
3 Antidotes Not Applicable
4 Charcoal Not Applicable
5 Diuretics, Potassium Sparing Not Applicable
6 Protective Agents Not Applicable
7 Sodium Channel Blockers Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phenytoin and Multidose Activated Charcoal Completed NCT00823264 Not Applicable Activated Charcoal

Search NIH Clinical Center for Phenytoin Toxicity

Genetic Tests for Phenytoin Toxicity

Anatomical Context for Phenytoin Toxicity

MalaCards organs/tissues related to Phenytoin Toxicity:

41
Thyroid, Brain

Publications for Phenytoin Toxicity

Articles related to Phenytoin Toxicity:

(show all 37)
# Title Authors Year
1
Phenytoin Toxicity. ( 28632869 )
2017
2
Phenytoin toxicity in two-month-old Thai infant with CYP2C9 gene polymorphism--A case report. ( 25998968 )
2016
3
Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity? ( 27076716 )
2016
4
NAT2 gene polymorphism: covert drug interaction causing phenytoin toxicity. ( 27487996 )
2016
5
Inappropriate utilization of the Sheiner-Tozer equation to determine phenytoin toxicity. ( 25661096 )
2015
6
Psychosis as Harbinger of Phenytoin Toxicity. ( 26862279 )
2015
7
Neurological manifestation of phenytoin toxicity, resulting from drug interaction with chloramphenicol: a case report. ( 29144066 )
2015
8
Fluoxetine-induced phenytoin toxicity: a clinical reminder about the perils of polypharmacy. ( 26411853 )
2015
9
Use of multi-dose activated charcoal in phenytoin toxicity secondary to genetic polymorphism. ( 25597548 )
2015
10
Free phenytoin toxicity. ( 24768668 )
2014
11
Phenytoin toxicity unlikely to result in arrhythmias. ( 24394934 )
2014
12
Phenytoin toxicity unlikely to result in arrhythmias--reply. ( 24394935 )
2014
13
Activated Charcoal Does Not Reduce Duration of Phenytoin Toxicity in Hospitalized Patients. ( 24621645 )
2014
14
Oral phenytoin toxicity causing sinus arrest: a case report. ( 25343048 )
2014
15
Phenytoin toxicity in patients with traumatic brain injury. ( 25033851 )
2014
16
Phenytoin toxicity from cocaine adulteration. ( 24672596 )
2014
17
Ocular motor abnormalities in a patient with phenytoin toxicity--case report and minireview. ( 25459255 )
2014
18
Myristicin and phenytoin toxicity in an infant. ( 24903724 )
2014
19
When less is more: a case of phenytoin toxicity. ( 23536644 )
2013
20
Association of CYP2C9 polymorphisms with phenytoin toxicity in Indian patients. ( 23287317 )
2012
21
Possible long-acting risperidone-induced hypothermia precipitating phenytoin toxicity in an elderly patient. ( 21545623 )
2011
22
Phenytoin toxicity in a patient receiving concomitant use of phenytoin and S-1 plus cisplatin chemotherapy for advanced gastric cancer. ( 21677496 )
2011
23
A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. ( 21338443 )
2011
24
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study. ( 21395647 )
2011
25
Phenytoin toxicity presenting as acute meningo-encephalitis in children. ( 21339662 )
2011
26
Phenytoin toxicity in a patient receiving 5-fluorouracil-based chemotherapy for metastatic colorectal cancer. ( 22184487 )
2011
27
Phenytoin toxicity secondary to an oxcarbazepine-phenytoin 2C19 interaction. ( 21051688 )
2010
28
CYP2C9, CYP2C19, and ABCB1 genotype and hospitalization for phenytoin toxicity. ( 19617466 )
2009
29
Phenytoin toxicity and thyroid dysfunction. ( 19851414 )
2009
30
Phenytoin toxicity masquerading as motor neurone disease. ( 19302663 )
2009
31
Phenytoin toxicity due to genetic polymorphism. ( 19030785 )
2009
32
Significant drug interaction: phenytoin toxicity due to erlotinib. ( 17383767 )
2007
33
Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS). ( 12558586 )
2003
34
Paroxysmal dyskinesia in phenytoin toxicity. ( 12583484 )
2002
35
Phenytoin toxic encephalopathy. ( 8406715 )
1993
36
Athetosis and phenytoin toxicity. ( 835515 )
1977
37
Acute athetosis as a result of phenytoin toxicity in a child. ( 1247004 )
1976

Variations for Phenytoin Toxicity

Expression for Phenytoin Toxicity

Search GEO for disease gene expression data for Phenytoin Toxicity.

Pathways for Phenytoin Toxicity

Pathways related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 ABCB1 ALB CYP2C19 CYP2C9 NAT2 VKORC1
2
Show member pathways
12.4 CYP2C19 CYP2C9 NAT2
3
Show member pathways
11.62 CYP2C19 CYP2C9
4 11.6 CYP2C19 CYP2C9
5
Show member pathways
11.43 ABCB1 CYP2C19 CYP2C9
6
Show member pathways
11.33 ABCB1 CYP2C19 CYP2C9
7
Show member pathways
11.31 CYP2C19 CYP2C9
8
Show member pathways
11.24 CYP2C19 CYP2C9
9 11.2 CYP2C19 CYP2C9
10
Show member pathways
11.12 ABCB1 CYP2C19 CYP2C9
11 11.02 ABCB1 CYP2C9
12
Show member pathways
10.88 ABCB1 CYP2C19 CYP2C9
13
Show member pathways
10.86 CYP2C9 NAT2
14
Show member pathways
10.78 ABCB1 CYP2C9
15 10.67 ABCB1 CYP2C9
16 10.3 ABCB1 CYP2C19 CYP2C9

GO Terms for Phenytoin Toxicity

Cellular components related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.96 CYP2C19 CYP2C9
2 endoplasmic reticulum GO:0005783 8.92 ALB CYP2C19 CYP2C9 VKORC1

Biological processes related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.63 CYP2C19 CYP2C9 VKORC1
2 steroid metabolic process GO:0008202 9.43 CYP2C19 CYP2C9
3 exogenous drug catabolic process GO:0042738 9.4 CYP2C19 CYP2C9
4 organic acid metabolic process GO:0006082 9.37 CYP2C19 CYP2C9
5 xenobiotic metabolic process GO:0006805 9.33 CYP2C19 CYP2C9 NAT2
6 epoxygenase P450 pathway GO:0019373 9.32 CYP2C19 CYP2C9
7 omega-hydroxylase P450 pathway GO:0097267 9.26 CYP2C19 CYP2C9
8 monoterpenoid metabolic process GO:0016098 8.96 CYP2C19 CYP2C9
9 drug metabolic process GO:0017144 8.8 CYP2C19 CYP2C9 VKORC1

Molecular functions related to Phenytoin Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.61 CYP2C19 CYP2C9 VKORC1
2 iron ion binding GO:0005506 9.48 CYP2C19 CYP2C9
3 heme binding GO:0020037 9.46 CYP2C19 CYP2C9
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.4 CYP2C19 CYP2C9
5 drug binding GO:0008144 9.37 ALB CYP2C9
6 monooxygenase activity GO:0004497 9.32 CYP2C19 CYP2C9
7 steroid hydroxylase activity GO:0008395 9.26 CYP2C19 CYP2C9
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP2C19 CYP2C9
9 arachidonic acid epoxygenase activity GO:0008392 8.96 CYP2C19 CYP2C9
10 oxygen binding GO:0019825 8.8 ALB CYP2C19 CYP2C9

Sources for Phenytoin Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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