MCID: PHL007
MIFTS: 19

Philadelphia-Negative Chronic Myeloid Leukemia

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards integrated aliases for Philadelphia-Negative Chronic Myeloid Leukemia:

Name: Philadelphia-Negative Chronic Myeloid Leukemia 52

Classifications:



Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards based summary : Philadelphia-Negative Chronic Myeloid Leukemia is related to myeloid leukemia and leukemia, chronic myeloid. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Signaling by Rho GTPases and Endometrial cancer. Affiliated tissues include myeloid, t cells and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

Graphical network of the top 20 diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to Philadelphia-Negative Chronic Myeloid Leukemia

Symptoms & Phenotypes for Philadelphia-Negative Chronic Myeloid Leukemia

GenomeRNAi Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.14 ABL1 BCR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.14 ABL1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.14 BCR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.14 BCR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.14 ABL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.14 BCR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.14 ABL1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.14 ABL1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.14 BCR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.14 BCR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.14 BCR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.14 BCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.14 BCR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.14 ABL1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.14 ABL1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.14 ABL1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.14 ABL1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.14 ABL1 BCR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.14 ABL1 BCR
20 Decreased viability GR00055-A-2 10.07 BCR
21 Decreased viability GR00221-A-1 10.07 ABL1
22 Decreased viability GR00221-A-2 10.07 ABL1 BCR
23 Decreased viability GR00221-A-3 10.07 ABL1
24 Decreased viability GR00221-A-4 10.07 BCR
25 Decreased viability GR00301-A 10.07 BCR
26 Decreased viability GR00342-S-1 10.07 ABL1
27 Decreased viability GR00342-S-2 10.07 ABL1
28 Decreased viability GR00342-S-3 10.07 ABL1 BCR
29 Decreased viability GR00402-S-2 10.07 ABL1 BCR
30 Decreased cell migration GR00055-A-1 9.26 ABL1 BCR
31 Decreased circadian period length GR00213-A 9.16 ABL1 BCR

Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

Search Clinical Trials , NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

40
Myeloid, T Cells, B Cells

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

(show all 11)
# Title Authors PMID Year
1
Case Report of acute myeloid leukemia with "WT1, ATRX, CEBPA, CSMD1, IKZF1, and LRP1B mutation and translocation between chromosome 1 and 19" developing from Philadelphia-negative chronic myeloid leukemia after TKI therapy. 61
32011516 2020
2
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. 61
19480935 2009
3
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. 61
10534772 1999
4
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. 61
10526530 1999
5
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. 61
9809034 1998
6
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. 61
8536245 1995
7
Translocation of BCR to chromosome 9: a new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia. 61
7512367 1993
8
[Translocation T(2;9) in a patient with Philadelphia-negative chronic myeloid leukemia in blast crisis]. 61
1293788 1992
9
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. 61
2790772 1989
10
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. 61
2649233 1989
11
Trisomy 14 in refractory anemia with excess of blasts in transformation. 61
3677048 1987

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

Expression for Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for Philadelphia-Negative Chronic Myeloid Leukemia

GO Terms for Philadelphia-Negative Chronic Myeloid Leukemia

Cellular components related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.62 BCR ABL1

Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.43 BCR ABL1
2 protein phosphorylation GO:0006468 9.4 BCR ABL1
3 actin cytoskeleton organization GO:0030036 9.37 BCR ABL1
4 cellular response to lipopolysaccharide GO:0071222 9.32 BCR ABL1
5 protein autophosphorylation GO:0046777 9.26 BCR ABL1
6 regulation of cell cycle GO:0051726 9.16 BCR ABL1
7 neuromuscular process controlling balance GO:0050885 8.96 BCR ABL1
8 platelet-derived growth factor receptor signaling pathway GO:0048008 8.62 BCR ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 8.62 BCR ABL1

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....