MCID: PHL007
MIFTS: 21

Philadelphia-Negative Chronic Myeloid Leukemia

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards integrated aliases for Philadelphia-Negative Chronic Myeloid Leukemia:

Name: Philadelphia-Negative Chronic Myeloid Leukemia 53

Classifications:



Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards based summary : Philadelphia-Negative Chronic Myeloid Leukemia is related to myeloid leukemia and leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include myeloid, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

Diseases related to Philadelphia-Negative Chronic Myeloid Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 myeloid leukemia 29.7 ABL1 BCR
2 leukemia 29.1 ABL1 BCR
3 pdgfrb-associated chronic eosinophilic leukemia 11.6
4 myeloproliferative neoplasm 9.7 ABL1 BCR
5 leukemia, acute lymphoblastic 3 9.6 ABL1 BCR
6 leukemia, acute lymphoblastic 9.6 ABL1 BCR
7 precursor t-cell acute lymphoblastic leukemia 9.6 ABL1 BCR
8 bone marrow cancer 9.6 ABL1 BCR
9 essential thrombocythemia 9.6 ABL1 BCR
10 lymphoblastic leukemia 9.5 ABL1 BCR
11 leukemia, chronic myeloid 9.5 ABL1 BCR
12 hematologic cancer 9.4 ABL1 BCR
13 leukemia, acute myeloid 9.2 ABL1 BCR

Graphical network of the top 20 diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to Philadelphia-Negative Chronic Myeloid Leukemia

Symptoms & Phenotypes for Philadelphia-Negative Chronic Myeloid Leukemia

GenomeRNAi Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.27 BCR
2 Decreased viability GR00221-A-1 10.27 ABL1
3 Decreased viability GR00221-A-2 10.27 BCR ABL1
4 Decreased viability GR00221-A-3 10.27 ABL1
5 Decreased viability GR00221-A-4 10.27 BCR
6 Decreased viability GR00301-A 10.27 BCR
7 Decreased viability GR00342-S-1 10.27 ABL1
8 Decreased viability GR00342-S-2 10.27 ABL1
9 Decreased viability GR00342-S-3 10.27 BCR ABL1
10 Decreased viability GR00402-S-2 10.27 BCR ABL1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.14 ABL1 BCR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.14 ABL1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.14 BCR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.14 BCR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.14 ABL1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.14 BCR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.14 ABL1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.14 ABL1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.14 BCR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.14 BCR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.14 BCR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.14 BCR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.14 BCR
24 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.14 ABL1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.14 ABL1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.14 ABL1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.14 ABL1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.14 ABL1 BCR
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.14 ABL1 BCR
30 Decreased cell migration GR00055-A-1 9.26 ABL1 BCR
31 Increased circadian period length GR00213-A 8.96 ABL1 BCR

Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

Search Clinical Trials , NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

41
Myeloid

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

# Title Authors Year
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. ( 19480935 )
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. ( 10534772 )
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. ( 10526530 )
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. ( 9809034 )
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. ( 8536245 )
1995
6
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. ( 2790772 )
1989
7
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. ( 2649233 )
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

Expression for Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for Philadelphia-Negative Chronic Myeloid Leukemia

GO Terms for Philadelphia-Negative Chronic Myeloid Leukemia

Cellular components related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.62 ABL1 BCR

Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.46 ABL1 BCR
2 protein phosphorylation GO:0006468 9.43 ABL1 BCR
3 protein autophosphorylation GO:0046777 9.4 ABL1 BCR
4 peptidyl-tyrosine phosphorylation GO:0018108 9.37 ABL1 BCR
5 actin cytoskeleton organization GO:0030036 9.32 ABL1 BCR
6 cellular response to lipopolysaccharide GO:0071222 9.26 ABL1 BCR
7 regulation of cell cycle GO:0051726 9.16 ABL1 BCR
8 neuromuscular process controlling balance GO:0050885 8.96 ABL1 BCR
9 platelet-derived growth factor receptor signaling pathway GO:0048008 8.62 ABL1 BCR

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 8.96 ABL1 BCR
2 protein tyrosine kinase activity GO:0004713 8.62 ABL1 BCR

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....