Aliases & Classifications for Phimosis

MalaCards integrated aliases for Phimosis:

Name: Phimosis 12 29 44 15 63
Tight Foreskin 12
Tight Frenulum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2712
ICD10 33 N47.1
MeSH 44 D010688
NCIt 50 C26852
UMLS 73 C0031538

Summaries for Phimosis

PubMed Health : 63 About phimosis: Many parents feel concerned if their newborn or young boy’s foreskin cannot be pulled back. They may think his foreskin is too tight and that he might need an operation. But it is a little known fact that about 9 out of 10 boys’ foreskins are tight or stuck to the head of their penis when they are born. This is known as phimosis, and it is completely normal. It protects the sensitive head of the penis from rubbing against things, becoming too dry and coming into contact with germs like viruses or bacteria.Within the first three years of life, the stuck skin (adhesion) usually detaches, and tight foreskin usually loosens enough to be able to pull it back without any problems or pain. Treatment is only needed if the foreskin still can’t be pulled back in older boys or adult men.

MalaCards based summary : Phimosis, also known as tight foreskin, is related to lichen sclerosus and lichen sclerosus et atrophicus. An important gene associated with Phimosis is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and L1CAM interactions. The drugs Anti-Allergic Agents and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, smooth muscle and bone.

Wikipedia : 76 Phimosis is a condition in which the foreskin of the penis cannot be pulled back past the glans. A... more...

Related Diseases for Phimosis

Diseases related to Phimosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 lichen sclerosus 10.2
2 lichen sclerosus et atrophicus 10.0
3 balanitis 10.0
4 epispadias 10.0
5 diabetes mellitus 9.9
6 hypospadias 9.9
7 balanoposthitis 9.9
8 retinitis pigmentosa 9.8
9 leber congenital amaurosis 4 9.8
10 graft-versus-host disease 9.8
11 balanitis xerotica obliterans 9.8
12 retinitis 9.8
13 leukoplakia of penis 9.8
14 prune belly syndrome 9.7
15 epicanthus 9.7
16 vesicoureteral reflux 1 9.7
17 mycosis fungoides 9.7
18 aging 9.7
19 glucocorticoid resistance, generalized 9.7
20 cataract 9.7
21 ptosis 9.7
22 epidural abscess 9.7
23 cicatricial pemphigoid 9.7
24 urethritis 9.7
25 lymphangioma 9.7
26 cervicitis 9.7
27 dermatitis 9.7
28 cerebritis 9.7
29 primary syphilis 9.7
30 syphilis 9.7
31 paraphimosis 9.7
32 lichen planus 9.7
33 myotonic dystrophy 9.7
34 chronic graft versus host disease 9.7
35 hansen's disease 9.7
36 myotonia atrophica 9.7
37 penile cancer, adult 9.7
38 phacogenic glaucoma 9.6 ELN PEX19
39 penile disease 9.2 PEX19 WASHC4

Graphical network of the top 20 diseases related to Phimosis:



Diseases related to Phimosis

Symptoms & Phenotypes for Phimosis

Drugs & Therapeutics for Phimosis

PubMedHealth treatment related to Phimosis: 63

There is no need to treat phimosis in babies and toddlers right away. Parents should not try to force the foreskin back. This can be painful for the child and injure the foreskin, leading to scars that could later cause acquired phimosis. To keep the area clean, it is enough to wash the penis from the outside using warm water and mild soap.If a boy still has phimosis after the age of three, it is important to seek medical advice. The doctor will take a closer look and say whether treatment is advisable or whether you can wait and see how things develop.In most children, phimosis is treated using a steroid cream. This is known as a “conservative” treatment approach because surgery is not needed. The cream is applied to the foreskin twice a day for four to eight weeks. After two weeks parents can try to pull the foreskin back very gently in order to stretch it a little. Here it is important not to injure the skin. If the foreskin can be pulled back a bit, the cream can also be applied to the part of the glans that is exposed. Then the foreskin is returned to its normal position. This treatment is successful in most children. But it often has to be repeated after a while in order to have a more lasting effect.If conservative treatment doesn’t work, a small operation known as circumcision might be considered. This operation is also considered if boys have recurring inflammations or problems when urinating. Circumcision is always necessary if someone has phimosis due to scarring (acquired phimosis) or if the foreskin gets stuck behind the glans when it is pulled back (paraphimosis).Circumcision involves removing either part of the foreskin or all of it. If it is only partially removed, phimosis might come back again after a while. This cannot happen if all of the foreskin is removed.Circumcisions for the treatment of phimosis are routine operations. They are often done under general anesthetic in children, but sometimes only a local anesthetic is used in teenagers and adults.

Drugs for Phimosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Allergic Agents Phase 4
2 Anti-Inflammatory Agents Phase 4,Phase 1,Not Applicable
3 Dermatologic Agents Phase 4
4 mometasone furoate Phase 4
5 glucocorticoids Phase 4,Not Applicable
6 Hormone Antagonists Phase 4,Not Applicable
7 Hormones Phase 4,Not Applicable
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
9
Acetaminophen Approved Phase 1 103-90-2 1983
10
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
11
Ibuprofen Approved Phase 1 15687-27-1 3672
12
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
13
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
14 Anesthetics Phase 1,Not Applicable
15 Analgesics Phase 1
16 Analgesics, Non-Narcotic Phase 1
17 Anesthetics, General Phase 1
18 Anesthetics, Inhalation Phase 1
19 Anesthetics, Local Phase 1
20 Anti-Inflammatory Agents, Non-Steroidal Phase 1
21 Antipyretics Phase 1
22 Antirheumatic Agents Phase 1
23 Central Nervous System Depressants Phase 1
24 Cyclooxygenase Inhibitors Phase 1
25 Ketorolac Tromethamine Phase 1
26 Peripheral Nervous System Agents Phase 1
27 Platelet Aggregation Inhibitors Phase 1
28
Menthol Approved Not Applicable 2216-51-5 16666
29
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
30
Formaldehyde Approved, Vet_approved 50-00-0 712
31
Adenosine Approved, Investigational 58-61-7 60961
32
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
33 Immunosuppressive Agents Not Applicable
34 Retinol palmitate Not Applicable
35 triamcinolone acetonide Not Applicable
36 Triamcinolone diacetate Not Applicable
37 Triamcinolone hexacetonide Not Applicable
38 retinol Nutraceutical Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Treatment of Phimosis With Topical Steroid Cream -Double-blind, Randomized, Placebo-controlled Study Unknown status NCT01108198 Phase 4 Mometasone furoate cream;moisturizing cream
2 Safety and Acceptability of the PrePex™ Device for Male Circumcision in Zambia Completed NCT01844102 Phase 4
3 Mild Versus Potent Corticosteroids as Treatment for Phimosis in Children Withdrawn NCT00933023 Phase 4 hydrocortisone;Betamethasone
4 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
5 Safety and Efficacy Study of Non-Surgical MC Device for Adolescent Male Population Including Contraindicated Subjects Unknown status NCT02581722 Not Applicable
6 Follow Up Study to Evaluate a Non-Surgical Device for Adult Male Circumcision for Screen Failure Subjects Completed NCT02281435 Not Applicable
7 Observational Study of Male Circumcision Using PrePex Device Completed NCT01711411
8 Prospective, International Monosyn® Quick - Non Interventional Study Recruiting NCT03355001
9 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995 Not Applicable
10 Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis Recruiting NCT03295175
11 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808
12 The Role of 2-octyl Cyanoacrylate in Prevention of Recurrent Adhesions After Circumcision Active, not recruiting NCT01794221 Not Applicable
13 Natural History of IOL in Pseudo Exfoliation Syndrome Active, not recruiting NCT01255995
14 Intelligence Changes Following Minor Surgery Withdrawn NCT01483313

Search NIH Clinical Center for Phimosis

Cochrane evidence based reviews: phimosis

Genetic Tests for Phimosis

Genetic tests related to Phimosis:

# Genetic test Affiliating Genes
1 Phimosis 29

Anatomical Context for Phimosis

MalaCards organs/tissues related to Phimosis:

41
Skin, Smooth Muscle, Bone, Pituitary, Eye, Kidney, Bone Marrow

Publications for Phimosis

Articles related to Phimosis:

(show top 50) (show all 234)
# Title Authors Year
1
Postoperative epidural abscess after spinal anaesthesia for a circumcision necessitated by phimosis. ( 29477995 )
2018
2
Long-term follow-up of neodymium:YAG laser anterior capsulotomy for the treatment of anterior capsular phimosis. ( 29916304 )
2018
3
Prepuce sparing: Use of Z-plasty for treatment of phimosis and scarred foreskin. ( 29909192 )
2018
4
Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter. ( 29080015 )
2018
5
Simultaneous Occurrence of Balanoposthitis Circumscripta Plasmacellularis Zoon, Phimosis and <i>in Situ</i> Carcinoma of the Penis: Case Report with An Unusual Ulcerated Polypoid Variant of Zoon's Disease and a Carcinoma <i>in Situ</i> of Reserve Cell Type. ( 29483984 )
2018
6
Phimosis in a 10-yr-old Boy Without Urinary Infection-How to Inform Parents: Against Circumcision. ( 28753818 )
2017
7
Phimosis in a 10-yr-old Boy Without Urinary Infection-How to Inform Parents: For Circumcision. ( 28753815 )
2017
8
&amp;quot;Trident&amp;quot; preputial plasty for phimosis in childhood. ( 28359779 )
2017
9
Glans penis phimosis in antiquity as depicted upon two roman ex-votos. ( 29205160 )
2017
10
Prevalence of phimosis and foreskin sliding abnormalities in male adolescents and their correlation with later onset of first sexual intercourse. ( 29473383 )
2017
11
Comparative efficacy and safety of different circumcisions for patients with redundant prepuce or phimosis: A network meta-analysis. ( 28522221 )
2017
12
Para Phimosis Leading to Glans Gangrene - A Devastating Preventable Complication. ( 28418348 )
2017
13
Observation time and spontaneous resolution of primary phimosis in children. ( 29019581 )
2017
14
2D:4D indicates phimosis risk: A study on digit ratio and early foreskin development. ( 27390108 )
2016
15
Is steroids therapy effective in treating phimosis? A meta-analysis. ( 26725071 )
2016
16
Ultrastructural Analysis of the Foreskin in Patients With True Phimosis Treated or Not Treated With Topical Betamethasone and Hyaluronidase Ointment. ( 27443468 )
2016
17
Phimosis in male dromedary camels: Clinical findings and changes in the hemogram, nitric oxide metabolites, and testosterone concentrations. ( 26879996 )
2016
18
Commentary on &amp;quot;Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults&amp;quot;. ( 27275650 )
2016
19
Common urological problems in children: prepuce, phimosis, and buried penis. ( 27149978 )
2016
20
Preputial bacterial colonisation in uncircumcised male children: Is it related to phimosis? ( 26968283 )
2016
21
High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis. ( 26796413 )
2016
22
Fournier's gangrene of the penis in a 12-year-old patient secondary to phimosis. ( 27903000 )
2016
23
Pathological Investigation of Childhood Foreskin: Are Lichen Sclerosus and Phimosis Common? ( 26876402 )
2016
24
Postoperative occlusion of visual axis with fibrous membrane in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome: a case report. ( 27923362 )
2016
25
Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus. ( 26797058 )
2015
26
Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults. ( 26349852 )
2015
27
Shut Phimosis in the Priapus Fresco From Pompeii. ( 25987495 )
2015
28
Indurative Edema of the Prepuce Mimicing Phimosis, an Atypical Manifestation of Primary Syphilis. ( 26724885 )
2015
29
Acquired lymphangioma of the penis in a patient with severe phimosis. ( 26227086 )
2015
30
Topical corticosteroids for treating phimosis in boys. ( 25180668 )
2014
31
Capsulorhexis phimosis with anterior flexing ofA an accommodating IOL: Case report andA histopathological analyses. ( 24355727 )
2014
32
The universal condition: medical constructions of 'congenital phimosis' in twentieth century New Zealand and their implications for child rearing. ( 25095486 )
2014
33
Effect of topical steroid (0.05% clobetasol propionate) treatment in children with severe phimosis. ( 24044098 )
2013
34
Acute presentation of clitoral phimosis in a 16-year-old girl. ( 24127974 )
2013
35
Is half strength of 0.05A % betamethasone valerate cream still effective in the treatment of phimosis in young children? ( 23292538 )
2013
36
Role of human papillomaviruses in persistent and glucocorticoid-resistant juvenile phimosis. ( 22471970 )
2013
37
Phimosis in childhood. ( 23788454 )
2013
38
Anterior capsular phimosis occluding the capsulorhexis opening after cataract surgery in a diabetic patient with high hemoglobin A1C. ( 23448558 )
2013
39
Congenital phimosis in patients with and without lichen sclerosus: distinct expression patterns of tissue remodeling associated genes. ( 23174236 )
2013
40
Prepuce-sparing plasty and simple running suture for phimosis. ( 23463932 )
2013
41
Re: Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 24029358 )
2013
42
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
43
Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 22749426 )
2012
44
Acquired phimosis after plastibell circumcision: a preventable consequence. ( 22943316 )
2012
45
Enlargement lateral posthetectomy for phimosis in the infant: a new approach. ( 22503478 )
2012
46
Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis. ( 23302400 )
2012
47
Phimosis in children. ( 23002427 )
2012
48
An unusual case of foreskin phimosis after radiotherapy for rectal carcinoma. ( 22721756 )
2012
49
Severe phimosis leading to obstructive uropathy in a boy with lichen sclerosus. ( 22594961 )
2012
50
A novel approach to the surgical management of clitoral phimosis. ( 22555140 )
2012

Variations for Phimosis

Expression for Phimosis

Search GEO for disease gene expression data for Phimosis.

Pathways for Phimosis

GO Terms for Phimosis

Cellular components related to Phimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 8.62 ITGA1 ITGB3

Biological processes related to Phimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-matrix adhesion GO:0007160 9.16 ITGA1 ITGB3
2 integrin-mediated signaling pathway GO:0007229 8.96 ITGA1 ITGB3
3 extracellular matrix organization GO:0030198 8.8 ELN ITGA1 ITGB3

Molecular functions related to Phimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 8.62 ELN ITGB3

Sources for Phimosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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