MCID: PHL003
MIFTS: 30

Phlebotomus Fever

Categories: Infectious diseases

Aliases & Classifications for Phlebotomus Fever

MalaCards integrated aliases for Phlebotomus Fever:

Name: Phlebotomus Fever 12 43 15 17 71
Sandfly Fever 12 32
Sandfly-Borne Phleboviral Disease 12
Sandfly-Borne Bunyavirus Fever 12
Sandfly-Borne Arboviral Fever 12
Pappataci Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11360
ICD9CM 34 066.0
MeSH 43 D010217
SNOMED-CT 67 407476002
ICD10 32 A93.1
UMLS 71 C0030372

Summaries for Phlebotomus Fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Sandfly fever Naples virus, or has material basis in Sandfly fever sicilian virus, which are transmitted by Phlebotomus papatasi sandfly. The infection has symptom fever, has symptom severe frontal headaches, has symptom muscle ache, has symptom joint aches, has symptom flushing of the face, and has symptom tachycardia.

MalaCards based summary : Phlebotomus Fever, also known as sandfly fever, is related to west nile encephalitis and west nile fever. An important gene associated with Phlebotomus Fever is CD40LG (CD40 Ligand). Affiliated tissues include testes, kidney and neutrophil.

Wikipedia : 74 Pappataci fever (also known as Phlebotomus fever and, somewhat confusingly, sandfly fever and three-day... more...

Related Diseases for Phlebotomus Fever

Diseases related to Phlebotomus Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 west nile encephalitis 30.7 PRNT CD40LG
2 west nile fever 30.6 PRNT CD40LG
3 rift valley fever 30.0 SAP30 PRNT GTF2H1 CD40LG
4 meningoencephalitis 10.4
5 west nile virus 10.3
6 la crosse encephalitis 10.3 MED8 CD40LG
7 st. louis encephalitis 10.3 PRNT CD40LG
8 coccidioidomycosis 10.3
9 asymptomatic dengue 10.3 PRNT CD40LG
10 murray valley encephalitis 10.2 PRNT CD40LG
11 zika fever 10.2 PRNT CD40LG
12 q fever 10.2
13 aseptic meningitis 10.2
14 iridocyclitis 10.2
15 exanthem 10.2
16 viral encephalitis 10.2
17 visceral leishmaniasis 10.2
18 viral infectious disease 10.2
19 monkeypox 10.2 PRNT CD40LG
20 western equine encephalitis 10.2 PRNT CD40LG
21 hantavirus hemorrhagic fever with renal syndrome 10.2 PRNT CD40LG
22 plasmodium malariae malaria 10.2 MT-CYB CD40LG
23 middle cerebral artery infarction 10.2 MRS2 CD40LG
24 bacillary angiomatosis 10.1 CD40LG CCDC130
25 kala-azar 1 10.1
26 tick-borne encephalitis 10.1
27 neutropenia 10.1
28 tularemia 10.1
29 plague 10.1
30 lymphopenia 10.1
31 leishmaniasis 10.1
32 cutaneous leishmaniasis 10.1
33 meningitis 10.1
34 encephalitis 10.1
35 47,xyy 10.1
36 xeroderma pigmentosum, complementation group g 10.1 GTF2H2 GTF2H1
37 taeniasis 10.1 MT-CYB CD40LG
38 babesiosis 10.1 MT-CYB CD40LG
39 immunoglobulin switch sequences 10.1
40 triiodothyronine receptor auxiliary protein 10.1
41 yemenite deaf-blind hypopigmentation syndrome 10.1
42 branchiootic syndrome 1 10.1
43 neuroretinitis 10.1
44 viral meningitis 10.1
45 crimean-congo hemorrhagic fever 10.1
46 diarrhea 10.1
47 thrombocytopenia 10.1
48 viral hepatitis 10.1
49 hyperinsulinism 10.1
50 retinitis 10.1

Graphical network of the top 20 diseases related to Phlebotomus Fever:



Diseases related to Phlebotomus Fever

Symptoms & Phenotypes for Phlebotomus Fever

Drugs & Therapeutics for Phlebotomus Fever

Search Clinical Trials , NIH Clinical Center for Phlebotomus Fever

Cochrane evidence based reviews: phlebotomus fever

Genetic Tests for Phlebotomus Fever

Anatomical Context for Phlebotomus Fever

MalaCards organs/tissues related to Phlebotomus Fever:

40
Testes, Kidney, Neutrophil, Brain, Skin, T Cells

Publications for Phlebotomus Fever

Articles related to Phlebotomus Fever:

(show top 50) (show all 269)
# Title Authors PMID Year
1
Experimental Infection of Dogs with Toscana Virus and Sandfly Fever Sicilian Virus to Determine Their Potential as Possible Vertebrate Hosts. 61
32326097 2020
2
Phlebotomine sand flies in Southwest Germany: an update with records in new locations. 61
32312300 2020
3
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation. 61
31815967 2019
4
Circulation of Toscana Virus in a Sample Population of Corsica, France. 61
31487870 2019
5
Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal. 61
31514266 2019
6
Experimental Infection of Sand Flies by Massilia Virus and Viral Transmission by Co-Feeding on Sugar Meal. 61
30970559 2019
7
The Prevalence of Antibodies against Sandfly Fever Viruses and West Nile Virus in Cyprus. 61
31346541 2019
8
NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3. 61
30232186 2018
9
[Sandfly fever-a "neglected" disease]. 61
30151597 2018
10
Emerging arboviruses of clinical importance in Central Asia. 61
30067170 2018
11
Viola phlebovirus is a novel Phlebotomus fever serogroup member identified in Lutzomyia (Lutzomyia) longipalpis from Brazilian Pantanal. 61
29996902 2018
12
Isolation and sequencing of Dashli virus, a novel Sicilian-like virus in sandflies from Iran; genetic and phylogenetic evidence for the creation of one novel species within the Phlebovirus genus in the Phenuiviridae family. 61
29281639 2017
13
Seroprevalence study of Toscana virus and viruses belonging to the Sandfly fever Naples antigenic complex in central and southern Italy. 61
28237695 2017
14
Sandfly fever in Afghanistan-a sometimes overlooked disease of military importance: a case series and review of the literature. 61
29214621 2017
15
Direct evidence for an expanded circulation area of the recently identified Balkan virus (Sandfly fever Naples virus species) in several countries of the Balkan archipelago. 61
28851425 2017
16
Of phlebotomines (sandflies) and viruses: a comprehensive perspective on a complex situation. 61
28805633 2017
17
High Rates of Neutralizing Antibodies to Toscana and Sandfly Fever Sicilian Viruses in Livestock, Kosovo. 61
28518045 2017
18
Characterization of the Bujaru, frijoles and Tapara antigenic complexes into the sandfly fever group and two unclassified phleboviruses from Brazil. 61
28141497 2017
19
Novel and emergent sandfly-borne phleboviruses in Asia Minor: a systematic review. 61
27531681 2017
20
Seroprevalence of sandfly fever virus infection in military personnel on the western border of Iran. 61
27017407 2017
21
Sandfly Fever with Skin Lesions: A Case Series from Turkey. 61
28032114 2016
22
Detection of Leishmania infantum and a Novel Phlebovirus (Balkan Virus) from Sand Flies in Albania. 61
27788062 2016
23
Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR. 61
27248570 2016
24
Neutralization-based seroprevalence of Toscana virus and sandfly fever Sicilian virus in dogs and cats from Portugal. 61
27589865 2016
25
Seroprevalence of Sandfly-Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test. 61
27783676 2016
26
[Pappataci (sandfly fever) - a little known brought in Poland viral disease]. 61
27755512 2016
27
RNA Encapsidation and Packaging in the Phleboviruses. 61
27428993 2016
28
Phleboviruses associated with sand flies in arid bio-geographical areas of Central Tunisia. 61
26875761 2016
29
Phleboviruses and the Type I Interferon Response. 61
27338447 2016
30
Sadfly fever: two case reports. 61
27489469 2016
31
Complete Coding Sequences of Six Toscana Virus Strains Isolated from Human Patients in France. 61
27231377 2016
32
Sandfly-Borne Phlebovirus Isolations from Turkey: New Insight into the Sandfly fever Sicilian and Sandfly fever Naples Species. 61
27007326 2016
33
Complete Coding Sequences of Three Toscana Virus Strains Isolated from Sandflies in France. 61
26868387 2016
34
Laboratory Validation of the Sand Fly Fever Virus Antigen Assay. 61
26675463 2015
35
In silico analysis and modeling of putative T cell epitopes for vaccine design of Toscana virus. 61
28324549 2015
36
Phlebovirus infections in Greece. 61
25733059 2015
37
[Serological investigation of phlebovirus exposure in blood donors from the Mediterranean Province of Mersin, Turkey]. 61
26313281 2015
38
Toscana virus meningitis case in Switzerland: an example of the ezVIR bioinformatics pipeline utility for the identification of emerging viruses. 61
25658528 2015
39
Phlebovirus infection in Greece: a case report. 61
27418773 2015
40
Reverse genetics system for severe fever with thrombocytopenia syndrome virus. 61
25552716 2015
41
Phlebovirus and Leishmania detection in sandflies from eastern Thrace and northern Cyprus. 61
25499083 2014
42
Seroconversion for infectious pathogens among UK military personnel deployed to Afghanistan, 2008-2011. 61
25418685 2014
43
An outbreak of acute febrile illness caused by Sandfly Fever Sicilian Virus in the Afar region of Ethiopia, 2011. 61
25266349 2014
44
Presence of sandfly-borne phleboviruses of two antigenic complexes (Sandfly fever Naples virus and Sandfly fever Sicilian virus) in two different bio-geographical regions of Tunisia demonstrated by a microneutralisation-based seroprevalence study in dogs. 61
25306250 2014
45
Serosurvey for zoonotic viral and bacterial pathogens among slaughtered livestock in Egypt. 61
25198525 2014
46
New record of the suspected leishmaniasis vector Phlebotomus (Transphlebotomus) mascittii Grassi, 1908 (Diptera: Psychodidae: Phlebotominae)--the northernmost phlebotomine sandfly occurrence in the Palearctic region. 61
24737399 2014
47
Sandfly fever virus as a rare cause of acute viral hepatitis. 61
24602976 2014
48
Viral isolates of a novel putative phlebovirus in the Marche Region of Italy. 61
24534812 2014
49
Characterization of the Sandfly fever Naples species complex and description of a new Karimabad species complex (genus Phlebovirus, family Bunyaviridae). 61
24096318 2014
50
Neuroinvasive phlebovirus infection in Greece: a case report. 61
25378100 2014

Variations for Phlebotomus Fever

Expression for Phlebotomus Fever

Search GEO for disease gene expression data for Phlebotomus Fever.

Pathways for Phlebotomus Fever

GO Terms for Phlebotomus Fever

Cellular components related to Phlebotomus Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor TFIIH holo complex GO:0005675 8.96 GTF2H2 GTF2H1
2 transcription factor TFIIH core complex GO:0000439 8.62 GTF2H2 GTF2H1

Biological processes related to Phlebotomus Fever according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair GO:0006289 9.52 GTF2H2 GTF2H1
2 nucleotide-excision repair, DNA incision GO:0033683 9.51 GTF2H2 GTF2H1
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.5 MED8 GTF2H2 GTF2H1
4 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.49 GTF2H2 GTF2H1
5 transcription initiation from RNA polymerase I promoter GO:0006361 9.48 GTF2H2 GTF2H1
6 7-methylguanosine mRNA capping GO:0006370 9.46 GTF2H2 GTF2H1
7 termination of RNA polymerase I transcription GO:0006363 9.43 GTF2H2 GTF2H1
8 transcription elongation from RNA polymerase I promoter GO:0006362 9.4 GTF2H2 GTF2H1
9 nucleotide-excision repair, preincision complex assembly GO:0006294 9.37 GTF2H2 GTF2H1
10 global genome nucleotide-excision repair GO:0070911 9.26 GTF2H2 GTF2H1
11 nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006295 9.16 GTF2H2 GTF2H1
12 nucleotide-excision repair, DNA duplex unwinding GO:0000717 8.96 GTF2H2 GTF2H1
13 nucleotide-excision repair, preincision complex stabilization GO:0006293 8.62 GTF2H2 GTF2H1

Molecular functions related to Phlebotomus Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-dependent ATPase activity GO:0008094 8.96 GTF2H2 GTF2H1
2 RNA polymerase II CTD heptapeptide repeat kinase activity GO:0008353 8.62 GTF2H2 GTF2H1

Sources for Phlebotomus Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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