MCID: PHL001
MIFTS: 25

Phlyctenulosis

Categories: Neuronal diseases

Aliases & Classifications for Phlyctenulosis

MalaCards integrated aliases for Phlyctenulosis:

Name: Phlyctenulosis 12 15
Phlyctenular Keratoconjunctivitis 12 71
Strumous Ophthalmia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11581
ICD9CM 34 370.31
SNOMED-CT 67 193773009
ICD10 32 H16.25
UMLS 71 C0155080

Summaries for Phlyctenulosis

MalaCards based summary : Phlyctenulosis, also known as phlyctenular keratoconjunctivitis, is related to mycobacterium tuberculosis 1 and rosacea. An important gene associated with Phlyctenulosis is AOC1 (Amine Oxidase Copper Containing 1), and among its related pathways/superpathways are Tight junction and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Affiliated tissues include eye and lymph node.

Wikipedia : 74 Phlyctenular keratoconjunctivitis,is an inflammatory syndrome caused by a delayed (aka type-IV)... more...

Related Diseases for Phlyctenulosis

Diseases related to Phlyctenulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 mycobacterium tuberculosis 1 29.3 CD1B CD1A
2 rosacea 10.3
3 disease by infectious agent 10.1
4 exanthem 10.1
5 urinary tract infection 10.1
6 chlamydia 10.1
7 hidradenitis suppurativa 10.1
8 hidradenitis 10.1
9 cervical adenitis 10.1
10 lymph node tuberculosis 10.1
11 eye disease 10.1
12 conjunctivitis 10.1
13 allergic disease 10.1
14 keratoconjunctivitis 10.1
15 blepharitis 10.1
16 lymphadenitis 9.9
17 lice infestation 9.9
18 vasculitis 9.9
19 granulomatous dermatitis 9.8 CD1E CD1B
20 predominantly cortical thymoma 9.7 CD1E CD1A
21 tolosa-hunt syndrome 9.7 CD1E CD1A
22 dendritic cell thymoma 9.7 CD1E CD1A
23 multifocal motor neuropathy 9.7 CD1E CD1A
24 oral hairy leukoplakia 9.7 CD1E CD1A
25 mite infestation 9.7 CD1B CD1A
26 pityriasis rosea 9.7 CD1E CD1A
27 kimura disease 9.6 CD1E CD1A
28 juvenile xanthogranuloma 9.6 CD1E CD1A
29 malignant histiocytic disease 9.5 CD1E CD1B CD1A
30 central nervous system sarcoma 9.5 CD1E CD1B CD1A
31 mycobacterium malmoense 9.5 CD1E CD1B CD1A
32 lichen nitidus 9.5 CD1E CD1B CD1A
33 mixed type thymoma 9.5 CD1E CD1B CD1A
34 encapsulated thymoma 9.5 CD1E CD1B CD1A
35 sphenoid sinusitis 9.5 CD1E CD1B CD1A
36 chronic laryngitis 9.5 CD1E CD1B CD1A
37 rhinoscleroma 9.5 CD1E CD1B CD1A
38 reticulohistiocytic granuloma 9.5 CD1E CD1B CD1A
39 epithelial malignant thymoma 9.5 CD1E CD1B CD1A
40 inflamed seborrheic keratosis 9.5 CD1E CD1B CD1A
41 balloon cell malignant melanoma 9.5 CD1E CD1B CD1A
42 langerhans cell sarcoma 9.5 CD1E CD1B CD1A
43 spongiotic dermatitis 9.5 CD1E CD1B CD1A
44 necrobiosis lipoidica 9.5 CD1E CD1B CD1A
45 interdigitating dendritic cell sarcoma 9.5 CD1E CD1B CD1A
46 diencephalic astrocytoma 9.5 CD1E CD1B CD1A
47 orbital cancer 9.5 CD1E CD1B CD1A
48 granuloma annulare 9.5 CD1E CD1B CD1A
49 marginal corneal ulcer 9.5 CD1E CD1B CD1A
50 histiocytic and dendritic cell cancer 9.5 CD1E CD1B CD1A

Graphical network of the top 20 diseases related to Phlyctenulosis:



Diseases related to Phlyctenulosis

Symptoms & Phenotypes for Phlyctenulosis

Drugs & Therapeutics for Phlyctenulosis

Search Clinical Trials , NIH Clinical Center for Phlyctenulosis

Genetic Tests for Phlyctenulosis

Anatomical Context for Phlyctenulosis

MalaCards organs/tissues related to Phlyctenulosis:

40
Eye, Lymph Node

Publications for Phlyctenulosis

Articles related to Phlyctenulosis:

(show top 50) (show all 90)
# Title Authors PMID Year
1
A rare case of primary sinonasal tuberculosis presented with phlyctenular keratoconjunctivitis in a pediatric patient: A case report and literature review. 61
33607832 2021
2
Update on the pathogenesis and management of ocular rosacea: an interdisciplinary review. 61
32586107 2021
3
Bilateral Phlyctenular Keratoconjunctivitis in the Context of Hidradenitis Suppurativa: A Case Report and Literature Review. 61
33226311 2020
4
Safety and Efficacy of Scleral Lenses for Keratoconus. 61
32932400 2020
5
Topical Tacrolimus 0.03% for Maintenance Therapy in Steroid-Dependent, Recurrent Phlyctenular Keratoconjunctivitis. 61
29309358 2018
6
Phlyctenulosis: a systemic diagnosis made or missed in the blink of an eye. 61
27704610 2017
7
Phlyctenular keratoconjunctivitis among children in the tertiary eye hospital of Kathmandu, Nepal. 61
26903718 2015
8
ASSOCIATION BETWEEN PHLYCTENULAR CONJUNCTIVITIS AND INTESTINAL PARASITES. 61
26485849 2015
9
Re-emphasizing Thygeson's warning: conjunctival phlyctenulosis as presenting sign of impending clinical tuberculosis. 61
25433746 2014
10
Phlyctenular keratoconjunctivitis associated with Dolosigranulum pigrum. 61
24131340 2014
11
Phlyctenular keratoconjunctivitis - an atypically severe case treated with systemic biologic immunosuppressive therapy. 61
27625937 2014
12
Successful treatment of phlyctenular keratoconjunctivitis with topical cyclosporin A. 61
23566750 2013
13
Efficacy of azithromycin 1.5% eye drops in childhood ocular rosacea with phlyctenular blepharokeratoconjunctivitis. 61
23514194 2013
14
Tacrolimus ointment 0.03% for treatment of refractory childhood phlyctenular keratoconjunctivitis. 61
22525784 2012
15
The pediatric corneal infiltrate. 61
21597372 2011
16
Scrofuloderma and bilateral anterior staphyloma of eye: an unusual association. 61
21572740 2011
17
Clinical spectrum of pediatric blepharokeratoconjunctivitis. 61
21093331 2010
18
Keratitis in children as seen in a tertiary hospital in Africa. 61
18481476 2008
19
Phlyctenular keratoconjunctivitis in a patient with Staphylococcal blepharitis and ocular rosacea. 61
18302955 2008
20
Resolution of childhood recurrent corneal phlyctenulosis following eradication of an intestinal parasite. 61
18083588 2008
21
[Uveitis during the course of sarcoidosis in a child: difficult diagnosis of a case]. 61
18546926 2008
22
Cutaneous tuberculosis and phlyctenular keratoconjunctivitis: a forgotten association. 61
16880576 2006
23
Tuberculosis and the eye. 61
16986294 2006
24
Topical cyclosporine A in severe steroid-dependent childhood phlyctenular keratoconjunctivitis. 61
16386977 2006
25
Salzmann's nodular degeneration of the cornea: a review and case series. 61
16160490 2005
26
Fascicular keratitis in children: can corneal phlycten be mobile? 61
16181284 2005
27
Recurrent phlyctenular keratoconjunctivitis: a forme fruste manifestation of rosacea. 61
11294589 2001
28
Phlyctenular eye disease: a reappraisal. 61
10715381 2000
29
[Phlyctenular keratoconjunctivitis and lymph node tuberculosis]. 61
10641112 1999
30
[Bouchut's tubercles. Clinical and angiographic study, apropos of a case]. 61
9238476 1997
31
The effect of Staphylococcus aureus phage lysate vaccine on a rabbit model of staphylococcal blepharitis, phlyctenulosis, and catarrhal infiltrates. 61
8694093 1996
32
Phlyctenular keratoconjunctivitis a potentially blinding disorder. 61
22827417 1996
33
Tetracycline treatment of phlyctenulosis. 61
8035976 1994
34
Ocular tuberculosis. 61
8310395 1993
35
Effective treatment of phlyctenular keratoconjunctivitis with oral tetracycline. 61
8371924 1993
36
Antibody studies in a rabbit model of corneal phlyctenulosis and catarrhal infiltrates related to Staphylococcus aureus. 61
2032807 1991
37
SAFA test as an aid to the diagnosis of ocular tuberculosis. 61
2201625 1990
38
Blood histaminase in phlyctenulosis. 61
2517271 1989
39
[Phlyctenular keratoconjunctivitis in bacterial epibulbar infections]. 61
3695265 1987
40
Immunocytological study of phlyctenular eye disease. 61
3493984 1987
41
[Marginal phlyctenular keratoconjunctivitis of tuberculous origin (bovine tuberculosis)]. 61
3568243 1986
42
Survey of ophthalmic conditions in a Labrador community: II. Ocular disease. 61
6478308 1984
43
B- and T-lymphocytes in ocular disease. 61
6235470 1984
44
Phlyctenular keratoconjunctivitis. 61
6863802 1983
45
The phlycten, a come-back? 61
7067601 1982
46
Orally administered tetracycline for phlyctenular keratoconjunctivitis. 61
7270629 1981
47
Phlyctenular keratoconjunctivitis. 61
7264847 1981
48
Rabbit model of phlyctenulosis and catarrhal infiltrates. 61
7236094 1981
49
Phlyctenular eye disease in association with Hymenolepis nana in Egypt. 61
486380 1979
50
Serum immunoglobulins in phlyctenulosis. 61
615148 1977

Variations for Phlyctenulosis

Expression for Phlyctenulosis

Search GEO for disease gene expression data for Phlyctenulosis.

Pathways for Phlyctenulosis

Pathways related to Phlyctenulosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 CD1E CD1B CD1A
2 11.39 CD1B CD1A
3 11.14 CD1E CD1B CD1A
4 10.79 CD1E CD1B CD1A

GO Terms for Phlyctenulosis

Cellular components related to Phlyctenulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.33 CD1E CD1B CD1A
2 extracellular space GO:0005615 9.26 CD1E CD1B CD1A AOC1
3 external side of plasma membrane GO:0009897 8.8 CD1E CD1B CD1A

Biological processes related to Phlyctenulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.54 CD1E CD1B CD1A
2 immune response GO:0006955 9.5 CD1E CD1B CD1A
3 adaptive immune response GO:0002250 9.43 CD1E CD1B CD1A
4 positive regulation of T cell mediated cytotoxicity GO:0001916 9.33 CD1E CD1B CD1A
5 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.13 CD1E CD1B CD1A
6 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.8 CD1E CD1B CD1A

Molecular functions related to Phlyctenulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.33 CD1E CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.13 CD1E CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 8.8 CD1E CD1B CD1A

Sources for Phlyctenulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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