MCID: PHS025
MIFTS: 30

Phosphatase, Acid, of Tissues

Aliases & Classifications for Phosphatase, Acid, of Tissues

MalaCards integrated aliases for Phosphatase, Acid, of Tissues:

Name: Phosphatase, Acid, of Tissues 57
Lysosomal Acid Phosphatase 57 55
Acp3--Alpha Polypeptide 57

External Ids:

OMIM 57 171660

Summaries for Phosphatase, Acid, of Tissues

MalaCards based summary : Phosphatase, Acid, of Tissues, also known as lysosomal acid phosphatase, is related to acid phosphatase deficiency and salla disease. An important gene associated with Phosphatase, Acid, of Tissues is ACP2 (Acid Phosphatase 2, Lysosomal), and among its related pathways/superpathways are Innate Immune System and Phagosome. Affiliated tissues include kidney, liver and brain, and related phenotypes are behavior/neurological and cellular

Description from OMIM: 171660

Related Diseases for Phosphatase, Acid, of Tissues

Diseases related to Phosphatase, Acid, of Tissues via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 acid phosphatase deficiency 12.0
2 salla disease 10.0 LAMP2 LAMP1
3 danon disease 10.0 LAMP2 GAA
4 myopathy, x-linked, with excessive autophagy 10.0 LAMP2 GAA
5 glycogen storage disease ii 9.9 LAMP2 GAA
6 glycogen storage disease 9.9 LAMP2 GAA
7 colorectal cancer 9.9
8 aging 9.9
9 primary polycythemia 9.9
10 epilepsy 9.9
11 polycythemia 9.9
12 encephalopathy 9.9
13 atrial standstill 1 9.8 LAMP2 GAA

Graphical network of the top 20 diseases related to Phosphatase, Acid, of Tissues:



Diseases related to Phosphatase, Acid, of Tissues

Symptoms & Phenotypes for Phosphatase, Acid, of Tissues

Clinical features from OMIM:

171660

MGI Mouse Phenotypes related to Phosphatase, Acid, of Tissues:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ACP2 ACPP CTSB GAA LAMP2
2 cellular MP:0005384 9.55 ACP2 CTSB GAA LAMP1 LAMP2
3 growth/size/body region MP:0005378 9.35 ACP2 CTSB GAA LAMP1 LAMP2
4 integument MP:0010771 9.02 ACP2 ACPP CTSB LAMP1 LAMP2

Drugs & Therapeutics for Phosphatase, Acid, of Tissues

Search Clinical Trials , NIH Clinical Center for Phosphatase, Acid, of Tissues

Genetic Tests for Phosphatase, Acid, of Tissues

Anatomical Context for Phosphatase, Acid, of Tissues

MalaCards organs/tissues related to Phosphatase, Acid, of Tissues:

41
Kidney, Liver, Brain, Prostate, Cerebellum, Thymus, Cortex

Publications for Phosphatase, Acid, of Tissues

Articles related to Phosphatase, Acid, of Tissues:

(show top 50) (show all 75)
# Title Authors Year
1
Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy. ( 28076332 )
2017
2
Lysosomal Acid Phosphatase Biosynthesis and Dysfunction: A Mini Review Focused on Lysosomal Enzyme Dysfunction in Brain. ( 27132795 )
2016
3
Purkinje cell compartmentation in the cerebellum of the lysosomal Acid phosphatase 2 mutant mouse (nax - naked-ataxia mutant mouse). ( 24722417 )
2014
4
Spatial and temporal expression of lysosomal acid phosphatase 2 (ACP2) reveals dynamic patterning of the mouse cerebellar cortex. ( 23780826 )
2013
5
Platelet lysosomal acid phosphatase enzyme activity as a marker of platelet procoagulant activity. ( 19503638 )
2009
6
Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue. ( 17868323 )
2007
7
Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse. ( 15503243 )
2004
8
Dephosphorylation of cyst wall proteins by a secreted lysosomal acid phosphatase is essential for excystation of Giardia lamblia. ( 12076774 )
2002
9
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice. ( 11731469 )
2001
10
Lysosomal acid phosphatase activity and progesterone secretion by porcine corpora lutea at various periods of the luteal phase. ( 9090509 )
1997
11
Non-conventional role of lysosomal acid phosphatase in olfactory receptor axons: co-localization with growth-associated phosphoprotein-43. ( 9219951 )
1997
12
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. ( 9228031 )
1997
13
Molecular characterization of the lysosomal acid phosphatase from Drosophila melanogaster. ( 8676866 )
1996
14
Temperature dependent influence of As2O3, HgHPO4 and KCl on lysosomal acid phosphatase isolated from rat liver. ( 7531537 )
1994
15
Endocytosis of lysosomal acid phosphatase; involvement of mannose receptor and effect of lectins. ( 7804146 )
1994
16
In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase. ( 8509395 )
1993
17
Overexpression of uteroferrin, a lysosomal acid phosphatase found in porcine uterine secretions, results in its high rate of secretion from transfected fibroblasts. ( 8286614 )
1993
18
The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells. ( 8491206 )
1993
19
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV. ( 1425575 )
1992
20
Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins. ( 1353723 )
1992
21
Lysosomal acid phosphatase is internalized via clathrin-coated pits. ( 1468434 )
1992
22
Localization of lysosomal acid phosphatase mRNA in mouse tissues. ( 1506664 )
1992
23
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn. ( 1760845 )
1991
24
Mechanisms of a conversion from membrane associated lysosomal acid phosphatase to content forms. ( 1953791 )
1991
25
Molecular cloning of the mouse lysosomal acid phosphatase. ( 2059337 )
1991
26
Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes. ( 2209556 )
1990
27
Lysosomal acid phosphatase is transported via endosomes to lysosomes. ( 1689571 )
1990
28
Biosynthesis, processing, and intracellular transport of lysosomal acid phosphatase in rat hepatocytes. ( 1699935 )
1990
29
Alterations to N-linked oligosaccharides which affect intracellular transport rates and regulated secretion but not sorting of lysosomal acid phosphatase in Dictyostelium discoideum. ( 2122807 )
1990
30
Structure of the human lysosomal acid phosphatase gene. ( 2776754 )
1989
31
Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. ( 2712834 )
1989
32
Targeting of lysosomal acid phosphatase with altered carbohydrate. ( 2540767 )
1989
33
Lysosomal acid phosphatase is transported to lysosomes via the cell surface. ( 2583113 )
1989
34
Sequential processing of lysosomal acid phosphatase by a cytoplasmic thiol proteinase and a lysosomal aspartyl proteinase. ( 2684640 )
1989
35
High degree of homology between primary structure of human lysosomal acid phosphatase and human prostatic acid phosphatase. ( 2706086 )
1989
36
Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells. ( 3056714 )
1988
37
Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment. ( 3191910 )
1988
38
Immunocytochemical localization of lysosomal acid phosphatase in normal and "I-cell" fibroblasts. ( 3552677 )
1987
39
Effects of chlorpromazine-pretreated melanin on lysosomal acid phosphatase and N-acetyl-beta-D-glucosaminidase in bovine ciliary body and iris in vitro. ( 3723869 )
1986
40
Human tartrate-inhibitable lysosomal acid phosphatase. Purification, characterization, biosynthesis and intracellular transport. ( 3766012 )
1986
41
Characterization of lysosomal acid phosphatase from normal and malignant mammary tissue. ( 3943187 )
1986
42
Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells. ( 3904632 )
1985
43
Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts. ( 3160696 )
1985
44
Activation of lysosomal acid phosphatase of eosinophil leukocytes. ( 6164873 )
1981
45
Lysosomal acid phosphatase: activity and isoenzymes in separated normal human blood cells. ( 6966195 )
1980
46
An optimized lead capture electronhistochemical technique for the demonstration of lysosomal and non lysosomal acid phosphatase activity in nervous tissue. ( 7401951 )
1980
47
Lysosomal acid phosphatase hyperactivity in cobalt epilepsy. ( 7429584 )
1980
48
Lysosomal acid phosphatase decrease in nutritional encephalopathy in chicks. ( 7443096 )
1980
49
Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11. ( 730175 )
1978
50
A quantitative method for measurement of lysosomal acid phosphatase latency in cultured rat heart cells with 210Pb. ( 567635 )
1978

Variations for Phosphatase, Acid, of Tissues

Expression for Phosphatase, Acid, of Tissues

Search GEO for disease gene expression data for Phosphatase, Acid, of Tissues.

Pathways for Phosphatase, Acid, of Tissues

Pathways related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 ACPP CTSB GAA LAMP1 LAMP2
2 11.5 LAMP1 LAMP2
3 11.24 CTSB LAMP1 LAMP2
4 11.18 LAMP1 LAMP2
5 11.11 ACP2 CTSB GAA LAMP1 LAMP2

GO Terms for Phosphatase, Acid, of Tissues

Cellular components related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 ACP2 ACPP CTSB GAA LAMP1 LAMP2
2 lysosomal membrane GO:0005765 9.55 ACP2 ACPP GAA LAMP1 LAMP2
3 lysosomal lumen GO:0043202 9.54 ACP2 GAA LAMP2
4 late endosome GO:0005770 9.46 LAMP1 LAMP2
5 melanosome GO:0042470 9.43 CTSB LAMP1
6 ficolin-1-rich granule membrane GO:0101003 9.43 GAA LAMP1 LAMP2
7 autolysosome GO:0044754 9.4 LAMP1 LAMP2
8 azurophil granule membrane GO:0035577 9.26 ACPP GAA LAMP1 LAMP2
9 lysosome GO:0005764 9.1 ACP2 ACPP CTSB GAA LAMP1 LAMP2

Biological processes related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.32 LAMP1 LAMP2
2 viral entry into host cell GO:0046718 9.26 CTSB LAMP1
3 lysosome organization GO:0007040 9.16 ACP2 GAA
4 neutrophil degranulation GO:0043312 9.02 ACPP CTSB GAA LAMP1 LAMP2
5 muscle cell cellular homeostasis GO:0046716 8.96 GAA LAMP2

Molecular functions related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.26 ACP2 ACPP CTSB GAA
2 acid phosphatase activity GO:0003993 8.62 ACP2 ACPP

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