MCID: PHS025
MIFTS: 28

Phosphatase, Acid, of Tissues

Aliases & Classifications for Phosphatase, Acid, of Tissues

MalaCards integrated aliases for Phosphatase, Acid, of Tissues:

Name: Phosphatase, Acid, of Tissues 57
Lysosomal Acid Phosphatase 57 55
Acp3--Alpha Polypeptide 57

External Ids:

OMIM 57 171660

Summaries for Phosphatase, Acid, of Tissues

MalaCards based summary : Phosphatase, Acid, of Tissues, also known as lysosomal acid phosphatase, is related to acid phosphatase deficiency and salla disease. An important gene associated with Phosphatase, Acid, of Tissues is ACP2 (Acid Phosphatase 2, Lysosomal), and among its related pathways/superpathways are Innate Immune System and Phagosome. Affiliated tissues include liver, kidney and prostate, and related phenotypes are behavior/neurological and cellular

Description from OMIM: 171660

Related Diseases for Phosphatase, Acid, of Tissues

Diseases related to Phosphatase, Acid, of Tissues via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 acid phosphatase deficiency 11.8
2 salla disease 10.0 LAMP1 LAMP2
3 myopathy, x-linked, with excessive autophagy 9.9 GAA LAMP2
4 danon disease 9.9 GAA LAMP2
5 glycogen storage disease ii 9.8 GAA LAMP2
6 colorectal cancer 9.8
7 primary polycythemia 9.8
8 prostatitis 9.8
9 polycythemia 9.8
10 atrial standstill 1 9.7 GAA LAMP2
11 glycogen storage disease 9.4 GAA LAMP2

Graphical network of the top 20 diseases related to Phosphatase, Acid, of Tissues:



Diseases related to Phosphatase, Acid, of Tissues

Symptoms & Phenotypes for Phosphatase, Acid, of Tissues

Clinical features from OMIM:

171660

MGI Mouse Phenotypes related to Phosphatase, Acid, of Tissues:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ACPP CTSB GAA LAMP2 ACP2
2 cellular MP:0005384 9.55 CTSB GAA LAMP1 LAMP2 ACP2
3 growth/size/body region MP:0005378 9.35 CTSB GAA LAMP1 LAMP2 ACP2
4 integument MP:0010771 9.02 CTSB LAMP1 LAMP2 ACP2 ACPP

Drugs & Therapeutics for Phosphatase, Acid, of Tissues

Search Clinical Trials , NIH Clinical Center for Phosphatase, Acid, of Tissues

Genetic Tests for Phosphatase, Acid, of Tissues

Anatomical Context for Phosphatase, Acid, of Tissues

MalaCards organs/tissues related to Phosphatase, Acid, of Tissues:

41
Liver, Kidney, Prostate, Skin, Cerebellum, Brain

Publications for Phosphatase, Acid, of Tissues

Articles related to Phosphatase, Acid, of Tissues:

(show all 22)
# Title Authors Year
1
Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy. ( 28076332 )
2017
2
Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue. ( 17868323 )
2007
3
Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse. ( 15503243 )
2004
4
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. ( 9228031 )
1997
5
In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase. ( 8509395 )
1993
6
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV. ( 1425575 )
1992
7
Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins. ( 1353723 )
1992
8
Lysosomal acid phosphatase is internalized via clathrin-coated pits. ( 1468434 )
1992
9
Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes. ( 2209556 )
1990
10
Structure of the human lysosomal acid phosphatase gene. ( 2776754 )
1989
11
Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. ( 2712834 )
1989
12
Sequential processing of lysosomal acid phosphatase by a cytoplasmic thiol proteinase and a lysosomal aspartyl proteinase. ( 2684640 )
1989
13
Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells. ( 3056714 )
1988
14
Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment. ( 3191910 )
1988
15
Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells. ( 3904632 )
1985
16
Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts. ( 3160696 )
1985
17
Activation of lysosomal acid phosphatase of eosinophil leukocytes. ( 6164873 )
1981
18
Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11. ( 730175 )
1978
19
Liver-specific lysosomal acid phosphatase deficiency (Apl) on mouse chromosome 17. ( 600262 )
1977
20
Lysosomal Acid phosphatase deficiency: liver specific variant in the mouse. ( 17248764 )
1977
21
Activity and intracellular localization of lysosomal acid phosphatase in lymphocytes from patients with Hodgkin's disease, plasma cell myeloma and primary polycythemia. ( 1025804 )
1976
22
Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder. ( 5410815 )
1970

Variations for Phosphatase, Acid, of Tissues

Expression for Phosphatase, Acid, of Tissues

Search GEO for disease gene expression data for Phosphatase, Acid, of Tissues.

Pathways for Phosphatase, Acid, of Tissues

Pathways related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 ACPP CTSB GAA LAMP1 LAMP2
2 11.5 LAMP1 LAMP2
3 11.24 CTSB LAMP1 LAMP2
4 11.18 LAMP1 LAMP2
5 11.11 ACP2 CTSB GAA LAMP1 LAMP2

GO Terms for Phosphatase, Acid, of Tissues

Cellular components related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.88 ACP2 ACPP CTSB GAA LAMP1 LAMP2
2 lysosomal membrane GO:0005765 9.55 ACP2 ACPP GAA LAMP1 LAMP2
3 lysosomal lumen GO:0043202 9.5 ACP2 GAA LAMP2
4 late endosome GO:0005770 9.46 LAMP1 LAMP2
5 melanosome GO:0042470 9.43 CTSB LAMP1
6 ficolin-1-rich granule membrane GO:0101003 9.43 GAA LAMP1 LAMP2
7 autolysosome GO:0044754 9.37 LAMP1 LAMP2
8 azurophil granule membrane GO:0035577 9.26 ACPP GAA LAMP1 LAMP2
9 lysosome GO:0005764 9.1 ACP2 ACPP CTSB GAA LAMP1 LAMP2

Biological processes related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.32 LAMP1 LAMP2
2 viral entry into host cell GO:0046718 9.26 CTSB LAMP1
3 lysosome organization GO:0007040 9.16 ACP2 GAA
4 neutrophil degranulation GO:0043312 9.02 ACPP CTSB GAA LAMP1 LAMP2
5 muscle cell cellular homeostasis GO:0046716 8.96 GAA LAMP2

Molecular functions related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.26 ACP2 ACPP CTSB GAA
2 acid phosphatase activity GO:0003993 8.62 ACP2 ACPP

Sources for Phosphatase, Acid, of Tissues

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