MCID: PHS025
MIFTS: 29

Phosphatase, Acid, of Tissues

Aliases & Classifications for Phosphatase, Acid, of Tissues

MalaCards integrated aliases for Phosphatase, Acid, of Tissues:

Name: Phosphatase, Acid, of Tissues 57
Lysosomal Acid Phosphatase 57 55
Acp3--Alpha Polypeptide 57

External Ids:

OMIM 57 171660

Summaries for Phosphatase, Acid, of Tissues

MalaCards based summary : Phosphatase, Acid, of Tissues, also known as lysosomal acid phosphatase, is related to acid phosphatase deficiency and ceroid lipofuscinosis, neuronal, 3. An important gene associated with Phosphatase, Acid, of Tissues is ACP2 (Acid Phosphatase 2, Lysosomal), and among its related pathways/superpathways are Innate Immune System and Phagosome. Affiliated tissues include prostate, liver and kidney, and related phenotypes are behavior/neurological and cellular

More information from OMIM: 171660

Related Diseases for Phosphatase, Acid, of Tissues

Graphical network of the top 20 diseases related to Phosphatase, Acid, of Tissues:



Diseases related to Phosphatase, Acid, of Tissues

Symptoms & Phenotypes for Phosphatase, Acid, of Tissues

Clinical features from OMIM:

171660

MGI Mouse Phenotypes related to Phosphatase, Acid, of Tissues:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ACP2 ACPP CTSB GAA LAMP2
2 cellular MP:0005384 9.55 ACP2 CTSB GAA LAMP1 LAMP2
3 growth/size/body region MP:0005378 9.35 ACP2 CTSB GAA LAMP1 LAMP2
4 integument MP:0010771 9.02 ACP2 ACPP CTSB LAMP1 LAMP2

Drugs & Therapeutics for Phosphatase, Acid, of Tissues

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Genetic Tests for Phosphatase, Acid, of Tissues

Anatomical Context for Phosphatase, Acid, of Tissues

MalaCards organs/tissues related to Phosphatase, Acid, of Tissues:

41
Prostate, Liver, Kidney, Neutrophil, Brain, Bone, Thymus

Publications for Phosphatase, Acid, of Tissues

Articles related to Phosphatase, Acid, of Tissues:

(show top 50) (show all 266)
# Title Authors PMID Year
1
A new variant of the placental acid phosphatases: its implications regarding their subunit structures and genetical determination. 8
4656570 1972
2
A rare subunit variant shared by five acid phosphatase isozymes from human leukocytes and placentae. 8
5444878 1970
3
Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms. 9 38
17357082 2007
4
Kruppel-like factor 6 (KLF6) affects the promoter activity of the alpha1-proteinase inhibitor gene. 9 38
16431954 2006
5
A dileucine motif and a cluster of acidic amino acids in the second cytoplasmic domain of the batten disease-related CLN3 protein are required for efficient lysosomal targeting. 9 38
15469932 2004
6
The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes. 9 38
11801736 2002
7
Involvement of Sp1 elements in the promoter activity of genes affected in keratoconus. 9 38
11481261 2001
8
Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents. 9 38
9746610 1998
9
Site-directed mutagenesis of prostatic acid phosphatase. Catalytically important aspartic acid 258, substrate specificity, and oligomerization. 9 38
8077215 1994
10
Intracellular diversion of glycoprotein GP160 of human immunodeficiency virus to lysosomes as a strategy of AIDS gene therapy. 9 38
8370478 1993
11
In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase. 9 38
8509395 1993
12
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV. 9 38
1425575 1992
13
Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins. 9 38
1353723 1992
14
Structure of human prostatic acid phosphatase gene. 9 38
1375464 1992
15
A quantitative immunoelectronmicroscopic study on soluble, membrane-associated and membrane-bound lysosomal enzymes in human intestinal epithelial cells. 9 38
1743995 1991
16
Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes. 9 38
2209556 1990
17
Gene expression and prostate specificity of human prostatic acid phosphatase (PAP): evaluation by RNA blot analyses. 9 38
1688712 1990
18
Three predominant prostatic proteins. 9 38
1720287 1990
19
Phagolysosomal activity of macrophages in Nile tilapia (Oreochromis niloticus) infected in vitro by Aeromonas hydrophila: Infection and immunotherapy. 38
30599256 2019
20
The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover. 38
30075049 2018
21
Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels. 38
29636491 2018
22
Acid phosphatase 2 (ACP2) is required for membrane fusion during influenza virus entry. 38
28272419 2017
23
Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy. 38
28076332 2017
24
Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes. 38
27877110 2016
25
Lysosomal Acid Phosphatase Biosynthesis and Dysfunction: A Mini Review Focused on Lysosomal Enzyme Dysfunction in Brain. 38
27132795 2016
26
Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse. 38
26784182 2016
27
[Peculiarities of clinical and metabolic adaptation of newborns extracted by repeated cesarean section]. 38
25541819 2014
28
Cytotoxicity and cellular mechanisms involved in the toxicity of CdS quantum dots in hemocytes and gill cells of the mussel Mytilus galloprovincialis. 38
24636493 2014
29
Proteomic analysis of the Ehrlichia chaffeensis phagosome in cultured DH82 cells. 38
24558391 2014
30
Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells. 38
24644403 2014
31
Purkinje cell compartmentation in the cerebellum of the lysosomal Acid phosphatase 2 mutant mouse (nax - naked-ataxia mutant mouse). 38
24722417 2014
32
Spatial and temporal expression of lysosomal acid phosphatase 2 (ACP2) reveals dynamic patterning of the mouse cerebellar cortex. 38
23780826 2013
33
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. 38
22158965 2012
34
Platelet lysosomal acid phosphatase enzyme activity as a marker of platelet procoagulant activity. 38
19503638 2009
35
Two new Brazilian patients with Gómez-López-Hernández syndrome: reviewing the expanded phenotype with molecular insights. 38
18247421 2008
36
Current concepts of enzyme histochemistry in modern pathology. 38
18580069 2008
37
Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue. 38
17868323 2007
38
[Phosphatase activity in Amoeba proteus at pH 9.0]. 38
17933343 2007
39
Expression of a functional sphingomyelinase of Pseudomonas sp. TK4 in mammalian cells. 38
17284826 2007
40
Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse. 38
15503243 2004
41
Procoagulant potential of platelet alpha granules. 38
15745311 2004
42
Disruption of the phagosomal membrane and egress of Legionella pneumophila into the cytoplasm during the last stages of intracellular infection of macrophages and Acanthamoeba polyphaga. 38
15213149 2004
43
Tartrate-resistant acid phosphatase knockout mice. 38
14584904 2003
44
Alteration in cellular and biochemical markers of pulmonary toxicity in rat lung exposed to carpet dusts. 38
12955617 2003
45
Arrested apoptosis without nuclear fragmentation produced by efferent duct ligation in round spermatids and multinucleated giant cells of rat testis. 38
12773111 2003
46
Inhibition of human renal acid phosphatases by nephrotoxic micromolar concentrations of fluoride. 38
12484561 2002
47
Oocyte fertilization triggers acid phosphatase activity during Rhodnius prolixus embryogenesis. 38
12110294 2002
48
Dephosphorylation of cyst wall proteins by a secreted lysosomal acid phosphatase is essential for excystation of Giardia lamblia. 38
12076774 2002
49
Serum enzyme pattern and local enzyme gradients in chronic chagasic patients. 38
12658870 2002
50
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice. 38
11731469 2001

Variations for Phosphatase, Acid, of Tissues

Expression for Phosphatase, Acid, of Tissues

Search GEO for disease gene expression data for Phosphatase, Acid, of Tissues.

Pathways for Phosphatase, Acid, of Tissues

Pathways related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 LAMP2 LAMP1 GAA CTSB ACPP
2 11.5 LAMP2 LAMP1
3 11.27 LAMP2 LAMP1 CTSB
4 11.18 LAMP2 LAMP1
5 11.11 LAMP2 LAMP1 GAA CTSB ACP2

GO Terms for Phosphatase, Acid, of Tissues

Cellular components related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 LAMP2 LAMP1 GAA CTSB ACPP ACP2
2 lysosomal membrane GO:0005765 9.55 LAMP2 LAMP1 GAA ACPP ACP2
3 lysosomal lumen GO:0043202 9.54 LAMP2 GAA ACP2
4 late endosome GO:0005770 9.46 LAMP2 LAMP1
5 melanosome GO:0042470 9.43 LAMP1 CTSB
6 ficolin-1-rich granule membrane GO:0101003 9.43 LAMP2 LAMP1 GAA
7 autolysosome GO:0044754 9.4 LAMP2 LAMP1
8 azurophil granule membrane GO:0035577 9.26 LAMP2 LAMP1 GAA ACPP
9 lysosome GO:0005764 9.1 LAMP2 LAMP1 GAA CTSB ACPP ACP2

Biological processes related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.32 LAMP2 LAMP1
2 viral entry into host cell GO:0046718 9.26 LAMP1 CTSB
3 lysosome organization GO:0007040 9.16 GAA ACP2
4 neutrophil degranulation GO:0043312 9.02 LAMP2 LAMP1 GAA CTSB ACPP
5 muscle cell cellular homeostasis GO:0046716 8.96 LAMP2 GAA

Molecular functions related to Phosphatase, Acid, of Tissues according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.26 GAA CTSB ACPP ACP2
2 acid phosphatase activity GO:0003993 8.62 ACPP ACP2

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