MCID: PHT004
MIFTS: 35

Photoallergic Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Photoallergic Dermatitis

MalaCards integrated aliases for Photoallergic Dermatitis:

Name: Photoallergic Dermatitis 12 15
Dermatitis, Photoallergic 45 74
Photoallergic Contact Dermatitis 12
Photoallergic Eczema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3818
MeSH 45 D017454
UMLS 74 C0162824

Summaries for Photoallergic Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that is characterized by a delayed-type hypersensitivity cutaneous reaction in response to a photoantigen applied to the skin in individuals previously sensitized to the same substance, and has symptom erythematous papules, vesicles, or eczema.

MalaCards based summary : Photoallergic Dermatitis, also known as dermatitis, photoallergic, is related to ketoprofen photoallergic dermatitis and contact dermatitis, and has symptoms including erythematous papules An important gene associated with Photoallergic Dermatitis is AGPS (Alkylglycerone Phosphate Synthase). The drugs Betamethasone and Castor oil have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 77 Photodermatitis, sometimes referred to as sun poisoning or photoallergy, is a form of allergic contact... more...

Related Diseases for Photoallergic Dermatitis

Diseases related to Photoallergic Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 ketoprofen photoallergic dermatitis 12.6
2 contact dermatitis 11.0
3 dermatitis 10.6
4 allergic contact dermatitis 10.5
5 neutrophilic dermatosis, acute febrile 10.2
6 pulmonary fibrosis 10.2
7 erythema multiforme 10.2
8 pulpitis 10.2
9 urticaria 10.2
10 chronic actinic dermatitis 10.2
11 peptic ulcer disease 9.9 ATP4A PTGS2
12 fungal esophagitis 9.9 ATP12A ATP4A
13 diclofenac allergy 9.9 ATP12A ATP4A
14 gastroduodenal crohn's disease 9.9 ATP12A ATP4A
15 neonatal candidiasis 9.9 ATP12A ATP4A
16 squamous papillomatosis 9.9 ATP12A ATP4A
17 toxic megacolon 9.9 ATP12A ATP4A
18 aspiration pneumonitis 9.9 ATP12A ATP4A
19 gastrointestinal neuroendocrine benign tumor 9.9 ATP12A ATP4A
20 gastric antral vascular ectasia 9.9 ATP12A ATP4A
21 granulomatous gastritis 9.9 ATP12A ATP4A
22 esophageal candidiasis 9.9 ATP12A ATP4A
23 gastric neuroendocrine neoplasm 9.9 ATP12A ATP4A
24 acute laryngitis 9.9 ATP12A ATP4A
25 laryngitis 9.9 ATP12A ATP4A
26 duodenitis 9.9 ATP12A ATP4A
27 rumination disorder 9.9 ATP12A ATP4A
28 congenital disorder of deglycosylation 9.9 ATP12A ATP4A
29 bladder calculus 9.9 ATP12A ATP4A
30 ischemic neuropathy 9.9 ATP12A ATP4A
31 capillary disease 9.9 ATP12A ATP4A
32 peptic esophagitis 9.9 ATP12A ATP4A
33 dyskinesia of esophagus 9.9 ATP12A ATP4A
34 hernia, hiatus 9.9 ATP12A ATP4A
35 anismus 9.8 ATP12A ATP4A
36 postsurgical hypothyroidism 9.8 ATP12A ATP4A
37 lymphocytic colitis 9.8 ATP12A ATP4A
38 esophageal atresia/tracheoesophageal fistula 9.8 ATP12A ATP4A
39 clostridium difficile colitis 9.8 ATP12A ATP4A
40 diarrhea 1, secretory chloride, congenital 9.8 ATP12A ATP4A
41 esophagitis, eosinophilic, 1 9.8 ATP12A ATP4A
42 microscopic colitis 9.8 ATP12A ATP4A
43 laryngeal tuberculosis 9.8 ATP12A ATP4A
44 chronic laryngitis 9.8 ATP12A ATP4A
45 eosinophilic gastritis 9.8 ATP12A ATP4A
46 chronic intestinal vascular insufficiency 9.8 ATP12A ATP4A
47 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8 ATP12A ATP4A
48 jejunoileitis 9.8 ATP12A ATP4A
49 pancreatic steatorrhea 9.8 ATP12A ATP4A
50 esophageal varix 9.8 ATP12A ATP4A

Graphical network of the top 20 diseases related to Photoallergic Dermatitis:



Diseases related to Photoallergic Dermatitis

Symptoms & Phenotypes for Photoallergic Dermatitis

Symptoms:

12
  • erythematous papules

MGI Mouse Phenotypes related to Photoallergic Dermatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.26 AGPS ATP4A EHD1 PTGS2
2 homeostasis/metabolism MP:0005376 9.02 AGPS ATP12A ATP4A EHD1 PTGS2

Drugs & Therapeutics for Photoallergic Dermatitis

Drugs for Photoallergic Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
2
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 1 8001-79-4
3
Tretinoin Approved, Investigational, Nutraceutical Phase 1 302-79-4 444795 5538
4 Anti-Inflammatory Agents Phase 1,Not Applicable
5 Calcipotriene Phase 1
6 Betamethasone Valerate Phase 1 2152-44-5
7 Betamethasone-17,21-dipropionate Phase 1
8 Betamethasone sodium phosphate Phase 1
9 Betamethasone benzoate Phase 1
10 Castor Phase 1
11 Laxatives Phase 1
12 Cathartics Phase 1
13 Gastrointestinal Agents Phase 1
14 Dermatologic Agents Phase 1,Not Applicable
15 Keratolytic Agents Phase 1
16
Camphor Approved Not Applicable 464-49-3 159055
17
Piroxicam Approved, Investigational Not Applicable 36322-90-4 54676228 5280452
18
Oxybenzone Approved, Investigational Not Applicable 131-57-7 4632
19
Diclofenac Approved, Vet_approved Not Applicable 15307-86-5 3033
20
Ibuprofen Approved Not Applicable 15687-27-1 3672
21
Ketoprofen Approved, Vet_approved Not Applicable 22071-15-4 3825
22
Homosalate Approved, Investigational Not Applicable
23
Benzophenone Experimental Not Applicable 119-61-9 3102
24 Sunscreening Agents Not Applicable
25 Radiation-Protective Agents Not Applicable
26 Protective Agents Not Applicable
27 Pharmaceutical Solutions Not Applicable
28 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
29 2-ethylhexyl salicylate Not Applicable
30 Antirheumatic Agents Not Applicable
31 octylmethoxycinnamate Not Applicable
32 Peripheral Nervous System Agents Not Applicable
33 Photosensitizing Agents Not Applicable
34 Analgesics, Non-Narcotic Not Applicable
35 Analgesics Not Applicable
36 Terephthalylidene dicamphor sulfonic acid Not Applicable
37 Salicylates Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Evaluation of Potential Development of Photoallergic Skin Reaction After Use of MC2-01 Cream Completed NCT03899064 Phase 1 Application of MC2-01 Cream, irradiation;Application of MC2-01 Cream;Applications of MC2-01 vehicle, irradiation;Applications ofh MC2-01 vehicle;Control, irradiation;Control
2 Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment Completed NCT00645164 Phase 1 Xenaderm
3 NatrOVA Photoallergy Study - NatrOVA Creme Rinse in Healthy Volunteers Completed NCT00605956 Phase 1 NatrOVA Creme Rinse - 1%;NatrOVA Creme Rinse Vehicle Only;Blank Patch
4 Clinical Evaluation of the Photoallergy Potential of Atralin Gel Completed NCT00603772 Phase 1 Atralin (tretinoin) gel, 0.05%
5 Human Photoallergy Test (824/2016) Completed NCT02962869 Not Applicable BAY987517
6 To Test for Photo Allergy Reaction of Sunscreens Completed NCT02872220 Not Applicable SPF 50 Y65 110 (BAY987519);SPF 50 Y51 002 (BAY987519);SPF 15 V27 104 (BAY987519);Sodium chloride [NaCl]
7 18349-Human Photoallergy Test Completed NCT02823496 Not Applicable
8 Human Photoallergy Test Completed NCT02751515 Not Applicable
9 18850 - Human Photoallergy Test Completed NCT02751463 Not Applicable Sunscreening Sport Spray Rest (BAY987519)
10 18793 - Human Photoallergy Test Completed NCT02750488 Not Applicable BAY987517
11 Human Photoallergy Test Completed NCT02750449 Not Applicable Sun screening Sport Lotion, (BAY987516)
12 To Assess the Photosensitisation and Photoallergy Potential of a Cosmetic Facial Product in Healthy Participants Completed NCT03183518 Not Applicable
13 Multi-Centre European Photopatch Test Study Completed NCT00530387 Not Applicable 19 organic sunscreen filters and 5 topical NSAIDs
14 Photopatch Test Study (POST Study) Recruiting NCT03812887
15 18776 - Human Photoallergy Test Withdrawn NCT02751567 Not Applicable

Search NIH Clinical Center for Photoallergic Dermatitis

Cochrane evidence based reviews: dermatitis, photoallergic

Genetic Tests for Photoallergic Dermatitis

Anatomical Context for Photoallergic Dermatitis

MalaCards organs/tissues related to Photoallergic Dermatitis:

42
Skin, Testes, Neutrophil

Publications for Photoallergic Dermatitis

Articles related to Photoallergic Dermatitis:

(show all 11)
# Title Authors Year
1
Photoallergic dermatitis associated with fixed-dose combination of antiretroviral agent (abacavir-lamivudine-dolutegravir). ( 29851666 )
2018
2
Ketoprofen-induced photoallergic dermatitis. ( 28474616 )
2016
3
Generation of reactive intermediates in photoallergic dermatitis. ( 20585243 )
2010
4
Esomeprazole-induced photoallergic dermatitis. ( 20739778 )
2010
5
Photoallergic dermatitis induced by diltiazem. ( 17244089 )
2007
6
Phototoxic and photoallergic dermatitis caused by hydroxychloroquine. ( 15186388 )
2004
7
Efavirenz-induced photoallergic dermatitis in HIV. ( 11400003 )
2001
8
Photoallergic dermatitis to a pig feed additive. ( 7646399 )
1995
9
Photoallergic dermatitis from ethylenediamine. ( 3709156 )
1986
10
Photoallergic dermatitis from 8-methoxypsoralen. ( 148873 )
1978
11
Allergic and photoallergic dermatitis from diphenhydramine. ( 952531 )
1976

Variations for Photoallergic Dermatitis

Expression for Photoallergic Dermatitis

Search GEO for disease gene expression data for Photoallergic Dermatitis.

Pathways for Photoallergic Dermatitis

GO Terms for Photoallergic Dermatitis

Biological processes related to Photoallergic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.4 ATP12A ATP4A
2 potassium ion import across plasma membrane GO:1990573 9.37 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Photoallergic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Photoallergic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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