MCID: PHT004
MIFTS: 28

Photoallergic Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Photoallergic Dermatitis

MalaCards integrated aliases for Photoallergic Dermatitis:

Name: Photoallergic Dermatitis 12 15
Dermatitis, Photoallergic 44 71
Photoallergic Contact Dermatitis 12
Photoallergic Eczema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3818
MeSH 44 D017454
SNOMED-CT 67 111209006
UMLS 71 C0162824

Summaries for Photoallergic Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that is characterized by a delayed-type hypersensitivity cutaneous reaction in response to a photoantigen applied to the skin in individuals previously sensitized to the same substance, and has symptom erythematous papules, vesicles, or eczema.

MalaCards based summary : Photoallergic Dermatitis, also known as dermatitis, photoallergic, is related to ketoprofen photoallergic dermatitis and allergic contact dermatitis, and has symptoms including erythematous papules An important gene associated with Photoallergic Dermatitis is DEF8 (Differentially Expressed In FDCP 8 Homolog). The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and thyroid, and related phenotype is Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers.

Wikipedia : 74 Photodermatitis, sometimes referred to as sun poisoning or photoallergy, is a form of allergic contact... more...

Related Diseases for Photoallergic Dermatitis

Diseases related to Photoallergic Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 ketoprofen photoallergic dermatitis 11.6
2 allergic contact dermatitis 10.7
3 dermatitis 10.5
4 skin disease 10.3
5 spongiotic dermatitis 10.3
6 chronic actinic dermatitis 10.3
7 fibrosis of extraocular muscles, congenital, 1 10.1
8 neutrophilic dermatosis, acute febrile 10.1
9 erythema multiforme 10.1
10 pulpitis 10.1
11 allergic disease 10.1
12 cheilitis 10.1
13 pulmonary fibrosis 10.1
14 47,xyy 10.1
15 paresthesia 10.1
16 exanthem 10.0
17 esophagitis 10.0
18 urticaria 10.0
19 contact dermatitis 10.0
20 dysphagia 10.0
21 solar urticaria 10.0

Graphical network of the top 20 diseases related to Photoallergic Dermatitis:



Diseases related to Photoallergic Dermatitis

Symptoms & Phenotypes for Photoallergic Dermatitis

Symptoms:

12
  • erythematous papules

GenomeRNAi Phenotypes related to Photoallergic Dermatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 8.62 SLC22A6 UBAC2

Drugs & Therapeutics for Photoallergic Dermatitis

Drugs for Photoallergic Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
3
Butenafine Approved Phase 3 101828-21-1 2484
4
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
5 Xenon Experimental Phase 3 7440-63-3
6 Antifungal Agents Phase 3
7 Cytochrome P-450 Enzyme Inhibitors Phase 3
8 Anti-Infective Agents Phase 3
9 Hormone Antagonists Phase 3
10 Retinol palmitate Phase 3
11 retinol Phase 3
12 Hormones Phase 3
13 Anti-Infective Agents, Local Phase 3
14 Cytochrome P-450 CYP3A Inhibitors Phase 3
15
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
16
Tretinoin Approved, Investigational, Nutraceutical Phase 1 302-79-4 5538 444795
17 Dermatologic Agents Phase 1
18 Keratolytic Agents Phase 1
19 Betamethasone sodium phosphate Phase 1
20 Betamethasone benzoate Phase 1
21 Betamethasone-17,21-dipropionate Phase 1
22 Calcipotriene Phase 1
23 Betamethasone Valerate Phase 1 2152-44-5
24
Piroxicam Approved, Investigational 36322-90-4 5280452 54676228
25
Ketoprofen Approved, Vet_approved 22071-15-4 3825
26
Diclofenac Approved, Vet_approved 15307-86-5 3033
27
Camphor Approved 464-49-3 159055
28
Homosalate Approved, Investigational 118-56-9
29
Ibuprofen Approved 15687-27-1 3672
30
Oxybenzone Approved, Investigational 131-57-7 4632
31
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
32
Etofenamate Experimental 30544-47-9
33
Benzophenone Experimental 119-61-9 3102
34 Sunscreening Agents
35 Anti-Inflammatory Agents
36 Anti-Inflammatory Agents, Non-Steroidal
37 Radiation-Protective Agents
38 Analgesics, Non-Narcotic
39 2-ethylhexyl salicylate
40 octylmethoxycinnamate
41 Salicylates
42 Terephthalylidene dicamphor sulfonic acid
43 Analgesics
44 Antirheumatic Agents
45 Cyclooxygenase Inhibitors
46 Photosensitizing Agents
47 Pharmaceutical Solutions
48 Protective Agents
49 Immunologic Factors
50 Viscosupplements

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 HT201309- Human Photoallergy Test Completed NCT04532164 Phase 3 Butenafine HCl 1% (BAY1896425) - Induction Phase;Butenafine HCl 1% (BAY1896425) - Challenge Phase
2 An Evaluation of the Photoallergy Potential of NatrOVA Creme Rinse - 1% in Healthy Volunteers Completed NCT00605956 Phase 1 NatrOVA Creme Rinse - 1%;NatrOVA Creme Rinse Vehicle Only;Blank Patch
3 Clinical Evaluation of the Photoallergy Potential of Atralin Gel (Tretinoin Gel 0.05%) Completed NCT00603772 Phase 1 Atralin (tretinoin) gel, 0.05%
4 Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment Completed NCT00645164 Phase 1 Xenaderm
5 A 6-Week, Randomized Study to Evaluate the Potential of MC2-01 Cream to Induce Photoallergic Skin Reaction in Healthy Subjects, Using a Controlled Photopatch Test Design Completed NCT03899064 Phase 1 Induction: Application of MC2-01 Cream, irradiation;Induction: Application of MC2-01 Cream, no irradiation;Induction: Applications of MC2-01 vehicle, irradiation;Induction: Applications of MC2-01 vehicle, no irradiation;Challenge: Application of MC2-01 Cream, irradiation;Challenge: Application of MC2-01 Cream, no irradiation;Challenge: Applications of MC2-01 vehicle, irradiation;Challenge: Applications of MC2-01 vehicle, no irradiation;Challenge: Control, irradiation
6 A Prospective, Open, Comparative, Multi-Centre Photopatch Test Study of Patients Suspected of Photoallergy to Organic Sunscreens and Topical Non-steroidal Anti-inflammatory Drugs Used Within Europe Unknown status NCT03812887
7 Human Photoallergy Test Completed NCT02750488 BAY987517
8 A Randomized Study to Assess the Potential for Photoallergy of SPF 50 Y65 110, SPF 50 Y51 002 and SPF 15 V27 104 in Human Subjects Completed NCT02872220 SPF 50 Y65 110 (BAY987519);SPF 50 Y51 002 (BAY987519);SPF 15 V27 104 (BAY987519);Sodium chloride [NaCl]
9 Human Photoallergy Test Completed NCT02750449 Sun screening Sport Lotion, (BAY987516)
10 Human Photoallergy Test Completed NCT02751463 Sunscreening Sport Spray Rest (BAY987519)
11 Human Photoallergy Test Completed NCT02751515
12 A Prospective, Open, Multi-Centre Photopatch Test Study of Patients Suspected of Photoallergy to Organic Sunscreens and Topical Nonsteroidal Anti-inflammatory Drugs Used Within Europe. Completed NCT00530387 19 organic sunscreen filters and 5 topical NSAIDs
13 A Clinical Study to Assess the Photosensitisation and Photoallergy Potential of a Cosmetic Facial Product in Healthy Subjects Completed NCT03183518
14 Human Photoallergy Test Completed NCT02962869 BAY987517
15 Human Photoallergy Test Completed NCT02823496
16 Dermatological Assessment of Photoallergy and Phototoxicity Under Controlled and Maximised Conditions. Not yet recruiting NCT04250623
17 Dermatological Assessment of Primary Dermal Irritability Accumulated, Sensitization, Photoallergy and Phototoxicity. Not yet recruiting NCT04332445
18 Human Photoallergy Test Withdrawn NCT02751567

Search NIH Clinical Center for Photoallergic Dermatitis

Cochrane evidence based reviews: dermatitis, photoallergic

Genetic Tests for Photoallergic Dermatitis

Anatomical Context for Photoallergic Dermatitis

MalaCards organs/tissues related to Photoallergic Dermatitis:

40
Skin, Lymph Node, Thyroid

Publications for Photoallergic Dermatitis

Articles related to Photoallergic Dermatitis:

(show all 36)
# Title Authors PMID Year
1
Evaluation of phototoxicity of tattoo pigments using the 3 T3 neutral red uptake phototoxicity test and a 3D human reconstructed skin model. 61
32119999 2020
2
Ketoprofen-induced photoallergic dermatitis. 61
31184407 2019
3
New approach to predict photoallergic potentials of chemicals based on murine local lymph node assay. 61
29797419 2018
4
Photoallergic dermatitis associated with fixed-dose combination of antiretroviral agent (abacavir-lamivudine-dolutegravir). 61
29851666 2018
5
Ketoprofen-induced photoallergic dermatitis. 61
28474616 2016
6
Photoallergic reaction in a patient receiving vandetanib for metastatic follicular thyroid carcinoma: a case report. 61
25886034 2015
7
First reported case of tenofovir-induced photoallergic reaction. 61
23112433 2012
8
Hypersensitivity reactions to proton pump inhibitors. 61
22744268 2012
9
Generation of reactive intermediates in photoallergic dermatitis. 61
20585243 2010
10
Esomeprazole-induced photoallergic dermatitis. 61
20739778 2010
11
Cutaneous allergic reactions to tattoo ink. 61
19958434 2009
12
Photoallergic dermatitis induced by diltiazem. 61
17244089 2007
13
Photodermatitis with minimal inflammatory infiltrate: clinical inflammatory conditions with discordant histologic findings. 61
17122492 2006
14
[Histopathology of photodermatoses]. 61
17093995 2006
15
Celecoxib-induced photoallergic drug eruption. 61
15186233 2004
16
Phototoxic and photoallergic dermatitis caused by hydroxychloroquine. 61
15186388 2004
17
Efavirenz-induced photoallergic dermatitis in HIV. 61
11400003 2001
18
Evaluation of the photosensitive patient. 61
10604791 1999
19
[Photoallergic dermatitis]. 61
10524266 1999
20
Skin diseases seen in Kazanchis health center. 61
11957300 1998
21
Photocontact dermatitis from ketoprofen and tiaprofenic acid: cross-reactivity study in 12 consecutive patients. 61
9667440 1998
22
[Contact photoallergic eczema caused by ketoprofen]. 61
8763748 1996
23
[Cutaneous side-effects of nonsteroidal anti-inflammatory drugs (NSAID)]. 61
8578891 1995
24
Photoallergic dermatitis to a pig feed additive. 61
7646399 1995
25
[Photocontact allergy caused by benzydamine (Tantum)]. 61
2533588 1989
26
[Photoallergic dermatitis caused by the herbicide phenmedipham]. 61
2606004 1989
27
Tiaprofenic acid induced photosensitivity. 61
2752738 1989
28
[Pitfalls in occupational dermatology: airborne contact eczema caused by plants]. 61
2524373 1989
29
Photoallergy to systemic quinidine in the mouse: dose-response studies. 61
3222168 1988
30
Photoallergic dermatitis from ethylenediamine. 61
3709156 1986
31
[UV radiation as occupational environmental damage (author's transl)]. 61
6452259 1981
32
Photosensitivity reaction to dibucaine. Case report and experimental induction. 61
464631 1979
33
Photoallergic dermatitis from 8-methoxypsoralen. 61
148873 1978
34
[Unusual adverse effects of oral photochemotherapy (PUVA-therapy) in psoriasis]. 61
599020 1977
35
Allergic and photoallergic dermatitis from diphenhydramine. 61
952531 1976
36
[Photoallergic dermatitis caused by soaps]. 61
5054375 1972

Variations for Photoallergic Dermatitis

Expression for Photoallergic Dermatitis

Search GEO for disease gene expression data for Photoallergic Dermatitis.

Pathways for Photoallergic Dermatitis

GO Terms for Photoallergic Dermatitis

Sources for Photoallergic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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