MCID: PHT002
MIFTS: 36

Photokeratitis

Categories: Eye diseases

Aliases & Classifications for Photokeratitis

MalaCards integrated aliases for Photokeratitis:

Name: Photokeratitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13626
ICD10 33 H16.13
ICD9CM 35 370.24
NCIt 50 C118750
SNOMED-CT 68 1714005
UMLS 73 C0155078

Summaries for Photokeratitis

MalaCards based summary : Photokeratitis is related to interdigitating dendritic cell sarcoma and diabetic foot ulcers. An important gene associated with Photokeratitis is TCF12 (Transcription Factor 12), and among its related pathways/superpathways are Innate Immune System and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include eye, skin and brain, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Photokeratitis or ultraviolet keratitis is a painful eye condition caused by exposure of insufficiently... more...

Related Diseases for Photokeratitis

Diseases related to Photokeratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 interdigitating dendritic cell sarcoma 10.2 CD163 PTPRC
2 diabetic foot ulcers 10.1 IL6 MMP9
3 central nervous system sarcoma 10.1 CD163 CD68
4 histiocytic and dendritic cell cancer 10.1 CD163 PTPRC
5 acute transverse myelitis 10.1 IL6 MMP9
6 adult xanthogranuloma 10.1 CD163 CD68
7 blepharochalasis 10.1 CD68 MMP9
8 lymphoplasmacyte-rich meningioma 10.1 CD163 CD68
9 nodular tenosynovitis 10.1 CD68 PTPRC
10 extracutaneous mastocytoma 10.1 CD68 PTPRC
11 burns 10.1
12 malignant giant cell tumor of soft parts 10.1 CD68 PTPRC
13 central nervous system tuberculosis 10.1 CD163 FASLG MMP9
14 spleen cancer 10.1 CD163 CD68
15 glomeruloid hemangioma 10.1 CD68 PTPRC
16 petroclival meningioma 10.1 CD163 CD68
17 conventional fibrosarcoma 10.1 CD68 PTPRC
18 periosteal osteogenic sarcoma 10.1 FOS JUN
19 hodgkin's lymphoma, lymphocytic depletion 10.1 CD68 PTPRC
20 light chain deposition disease 10.1 CD68 MMP9
21 internal hemorrhoid 10.0 HSPA4 MMP9
22 brain sarcoma 10.0 CD68 JUN PTPRC
23 trigeminal nerve neoplasm 10.0 CD68 PTPRC
24 gastrointestinal system disease 10.0 IL6 MIF MMP9
25 pertussis 10.0 FOS IL6 JUN
26 reticulohistiocytic granuloma 10.0 CD163 CD68 PTPRC
27 neurilemmoma of the fifth cranial nerve 10.0 CD68 PTPRC
28 arteries, anomalies of 10.0 IL6 MMP9 NOS3
29 sarcoidosis 1 10.0 CD68 MIF PTPRC
30 synovitis 10.0 CD163 CD68 IL6
31 toxic myocarditis 9.9 JUN NOS3
32 acute vascular insufficiency of intestine 9.9 HSPA4 IL6
33 rheumatoid arthritis 9.8 FOS IL6 JUN MIF MMP9
34 epidural neoplasm 9.8 DNTT PTPRC
35 dendritic cell tumor 9.8 CD68 DNTT PTPRC
36 large intestine cancer 9.6 DNTT FASLG IL6 JUN MMP9
37 malaria 9.6 CD163 FASLG HSPA4 IL6 MIF MMP9
38 ewing sarcoma 9.3 DNTT FASLG HSPA4 IL6 JUN MMP9

Graphical network of the top 20 diseases related to Photokeratitis:



Diseases related to Photokeratitis

Symptoms & Phenotypes for Photokeratitis

MGI Mouse Phenotypes related to Photokeratitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.29 CD163 CD68 DNTT FASLG FOS IL6
2 immune system MP:0005387 10.25 CD163 CD68 DNTT FASLG FOS IL6
3 cellular MP:0005384 10.21 CD163 FASLG FOS HSPA4 IL6 JUN
4 homeostasis/metabolism MP:0005376 10.2 CD163 DNTT FASLG FOS IL6 JUN
5 behavior/neurological MP:0005386 10.18 FOS HSPA4 IL6 JUN MMP9 NOS3
6 endocrine/exocrine gland MP:0005379 10.1 FASLG FOS HSPA4 IL6 JUN NOS3
7 mortality/aging MP:0010768 10.1 FASLG FOS HSPA4 IL6 JUN MMP9
8 nervous system MP:0003631 10.06 FASLG FOS HSPA4 IL6 JUN MIF
9 normal MP:0002873 9.86 DNTT FASLG FOS JUN MIF NOS3
10 neoplasm MP:0002006 9.85 FASLG FOS IL6 MIF MMP9 PTPRC
11 respiratory system MP:0005388 9.7 CD163 FASLG IL6 JUN MMP9 NOS3
12 skeleton MP:0005390 9.56 CD68 FASLG FOS IL6 JUN MMP9
13 vision/eye MP:0005391 9.23 CD163 FASLG FOS IL6 JUN MMP9

Drugs & Therapeutics for Photokeratitis

Search Clinical Trials , NIH Clinical Center for Photokeratitis

Genetic Tests for Photokeratitis

Anatomical Context for Photokeratitis

MalaCards organs/tissues related to Photokeratitis:

41
Eye, Skin, Brain, Heart, Spleen, B Cells, Myeloid

Publications for Photokeratitis

Articles related to Photokeratitis:

(show all 21)
# Title Authors Year
1
Photokeratitis induced by ultraviolet radiation in travelers: A major health problem. ( 29067921 )
2018
2
Photokeratitis among restaurant workers: A case series. ( 29998493 )
2018
3
Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. ( 29104724 )
2017
4
Photokeratitis Linked to Metal Halide Bulbs in Two Gymnasiums - Philadelphia, Pennsylvania, 2011 and 2013. ( 27010342 )
2016
5
Mass photokeratitis following ultraviolet light exposure at a nightclub. ( 26851136 )
2016
6
Four Cases of Pediatric Photokeratitis Present to the Emergency Department After Watching the Same Theater Show. ( 27800238 )
2015
7
Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. ( 23340653 )
2013
8
Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops. ( 22393271 )
2012
9
Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation. ( 21527993 )
2011
10
Behavioral and neurophysiological correlates of nociception in an animal model of photokeratitis. ( 20417694 )
2010
11
Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice. ( 18436209 )
2008
12
Photokeratitis following the manipulation of aquaria disinfection lamps. ( 17351245 )
2007
13
Photokeratitis and UV-radiation burns associated with damaged metal halide lamps. ( 15066878 )
2004
14
Mass photokeratitis following exposure to unprotected ultraviolet light. ( 12848407 )
2003
15
Photokeratitis and other phototoxic effects on the cornea and conjunctiva. ( 12537642 )
2002
16
Photokeratitis from subablative 193-nanometer excimer laser radiation. ( 1390406 )
1992
17
Photokeratitis from 193 nm argon-fluoride laser radiation. ( 1886933 )
1991
18
Corneal damage in photokeratitis--why is it so painful? ( 2381684 )
1990
19
Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis. ( 2383204 )
1990
20
Photokeratitis: laboratory versus solar exposure. ( 3182210 )
1988
21
Light penetration of normal and photokeratitis induced rabbit cornea. ( 6720295 )
1984

Variations for Photokeratitis

Expression for Photokeratitis

Search GEO for disease gene expression data for Photokeratitis.

Pathways for Photokeratitis

Pathways related to Photokeratitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CD68 FASLG FOS IL6 JUN MIF
2
Show member pathways
13.2 FOS HSPA4 IL6 JUN NOS3 OGN
3
Show member pathways
13.15 FASLG FOS IL6 JUN OGN PTPRC
4
Show member pathways
12.98 FASLG FOS IL6 JUN MMP9
5
Show member pathways
12.96 FASLG FOS JUN MMP9 NOS3
6
Show member pathways
12.84 FASLG FOS IL6 JUN MMP9 PTPRC
7
Show member pathways
12.81 FASLG FOS HSPA4 IL6 PTPRC
8 12.74 FASLG FOS IL6 JUN MMP9
9
Show member pathways
12.64 FASLG FOS JUN NOS3
10
Show member pathways
12.51 FOS JUN NOS3 PTPRC
11
Show member pathways
12.47 FOS IL6 JUN NOS3
12
Show member pathways
12.36 FOS IL6 JUN PTPRC
13
Show member pathways
12.24 FOS IL6 JUN MIF
14
Show member pathways
12.24 FOS IL6 JUN MMP9
15
Show member pathways
12.01 FOS IL6 JUN OGN
16
Show member pathways
11.99 FOS IL6 JUN
17 11.97 FOS JUN MMP9 NOS3
18
Show member pathways
11.96 IL6 JUN NOS3
19
Show member pathways
11.91 FASLG FOS JUN
20 11.87 FOS IL6 MIF MMP9
21 11.85 IL6 JUN NOS3
22 11.84 CD163 CD68 IL6 PTPRC
23 11.81 FASLG FOS IL6 MMP9
24 11.8 FOS IL6 JUN
25 11.78 FOS IL6 JUN MMP9
26
Show member pathways
11.77 FOS IL6 JUN
27 11.77 FOS IL6 JUN
28 11.74 FOS IL6 JUN
29
Show member pathways
11.7 FASLG FOS JUN
30 11.7 FOS IL6 JUN
31 11.67 CD163 IL6 PTPRC
32 11.61 JUN MMP9 NOS3
33
Show member pathways
11.57 FASLG FOS JUN
34 11.56 CD163 CD68 IL6 MMP9
35
Show member pathways
11.55 FOS JUN MMP9
36 11.51 FOS IL6 JUN
37 11.48 FASLG IL6 JUN
38 11.48 FOS IL6 JUN MMP9
39
Show member pathways
11.46 FOS HSPA4 JUN
40 11.42 FOS JUN MMP9
41
Show member pathways
11.39 FOS JUN MMP9
42 11.34 FOS HSPA4 JUN
43 11.27 FASLG FOS IL6 JUN
44 11.2 FOS IL6 JUN
45 11.11 FASLG FOS IL6 JUN
46 11.1 MMP9 NOS3
47 11.09 FOS JUN
48 11.07 FOS JUN
49 11.07 FOS JUN
50 11.05 FOS JUN

GO Terms for Photokeratitis

Cellular components related to Photokeratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.46 DNTT JUN TCF12 USF1
2 transcription factor complex GO:0005667 9.26 FOS JUN TCF12 USF1
3 transcription factor AP-1 complex GO:0035976 8.62 FOS JUN

Biological processes related to Photokeratitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CD163 FOS IL6 MIF
2 positive regulation of transcription, DNA-templated GO:0045893 9.8 FOS IL6 JUN TCF12 USF1
3 positive regulation of apoptotic process GO:0043065 9.76 FASLG IL6 JUN MMP9
4 cytokine-mediated signaling pathway GO:0019221 9.67 FASLG FOS IL6 MMP9
5 regulation of DNA-binding transcription factor activity GO:0051090 9.52 FOS JUN
6 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.51 FASLG MMP9
7 cellular response to extracellular stimulus GO:0031668 9.48 FOS PTPRC
8 response to lipopolysaccharide GO:0032496 9.46 FASLG FOS JUN NOS3
9 response to muscle stretch GO:0035994 9.43 FOS JUN
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 IL6 MIF PTPRC
11 negative regulation of protein autophosphorylation GO:0031953 9.32 JUN PTPRC
12 cellular response to cadmium ion GO:0071276 9.13 FOS JUN MMP9
13 cellular response to reactive oxygen species GO:0034614 8.8 FOS JUN MMP9

Molecular functions related to Photokeratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 CD163 DNTT FASLG FOS HSPA4 IL6
2 double-stranded DNA binding GO:0003690 9.43 FOS JUN USF1
3 R-SMAD binding GO:0070412 9.32 FOS JUN
4 HMG box domain binding GO:0071837 9.16 JUN TCF12
5 cAMP response element binding GO:0035497 8.96 JUN TCF12

Sources for Photokeratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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