MCID: PHT002
MIFTS: 28

Photokeratitis

Categories: Neuronal diseases

Aliases & Classifications for Photokeratitis

MalaCards integrated aliases for Photokeratitis:

Name: Photokeratitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13626
ICD9CM 34 370.24
NCIt 49 C118750
SNOMED-CT 67 1714005
ICD10 32 H16.13
UMLS 71 C0155078

Summaries for Photokeratitis

MalaCards based summary : Photokeratitis is related to keratitis, hereditary and hyperhidrosis, gustatory. An important gene associated with Photokeratitis is TRPA1 (Transient Receptor Potential Cation Channel Subfamily A Member 1), and among its related pathways/superpathways are Parkinson disease and Development Endothelin-1/EDNRA signaling. Affiliated tissues include eye and skin, and related phenotype is integument.

Wikipedia : 74 Photokeratitis or ultraviolet keratitis is a painful eye condition caused by exposure of insufficiently... more...

Related Diseases for Photokeratitis

Diseases related to Photokeratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.4
2 hyperhidrosis, gustatory 10.4 TRPV1 TRPA1
3 detrusor sphincter dyssynergia 10.4 TRPV1 TRPA1
4 trigeminal nerve disease 10.3 TRPV1 TRPA1
5 trigeminal neuralgia 10.2 TRPV1 TRPA1
6 keratopathy 10.2
7 corneal ulcer 10.2
8 climatic droplet keratopathy 10.2
9 dentin sensitivity 10.2 TRPV1 TRPM8 TRPA1
10 familial episodic pain syndrome 10.2 TRPV1 TRPM8 TRPA1
11 paroxysmal extreme pain disorder 10.2 TRPV1 TRPM8 TRPA1
12 nerve compression syndrome 10.0 TRPV1 IL6
13 prosthetic joint infection 10.0 IL6 IL1B
14 periodontitis, chronic 10.0 IL6 IL1B
15 uremic pruritus 10.0 IL6 IL1B
16 indolent myeloma 10.0 IL6 IL1B
17 anaerobic pneumonia 10.0 IL6 IL1B
18 glomeruloid hemangioma 10.0 IL6 IL1B
19 stachybotrys chartarum 10.0 IL6 IL1B
20 suppurative periapical periodontitis 10.0 IL6 IL1B
21 periapical periodontitis 10.0 IL6 IL1B
22 eales disease 10.0 IL6 IL1B
23 carbuncle 10.0 IL6 IL1B
24 chemical colitis 10.0 IL6 IL1B
25 aortitis 10.0 IL6 IL1B
26 recurrent corneal erosion 10.0 IL6 IL1B
27 pneumonic tularemia 10.0 IL6 IL1B
28 lung abscess 10.0 IL6 IL1B
29 chlamydia pneumonia 10.0 IL6 IL1B
30 gingival recession 10.0 IL6 IL1B
31 idiopathic neutropenia 10.0 IL6 IL1B
32 irritant dermatitis 10.0 IL6 IL1B
33 background diabetic retinopathy 10.0 IL6 IL1B
34 laryngitis 10.0 IL6 IL1B
35 vaginal discharge 10.0 IL6 IL1B
36 euthyroid sick syndrome 10.0 IL6 IL1B
37 orchitis 9.9 IL6 IL1B
38 trichomoniasis 9.9 IL6 IL1B
39 glossitis 9.9 IL6 IL1B
40 funisitis 9.9 IL6 IL1B
41 autonomic nervous system disease 9.9 TRPV1 TRPA1 IL6
42 central nervous system vasculitis 9.9 IL6 IL1B
43 urethritis 9.9 IL6 IL1B
44 tendinitis 9.9 IL6 IL1B
45 chronic conjunctivitis 9.9 IL6 IL1B
46 erysipelas 9.9 IL6 IL1B
47 subacute thyroiditis 9.9 IL6 IL1B
48 conjunctivochalasis 9.9 IL6 IL1B
49 cervicitis 9.9 IL6 IL1B
50 autoimmune disease of eyes, ear, nose and throat 9.9 IL6 IL1B

Graphical network of the top 20 diseases related to Photokeratitis:



Diseases related to Photokeratitis

Symptoms & Phenotypes for Photokeratitis

MGI Mouse Phenotypes related to Photokeratitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 CXCL17 GPX8 IL1B IL6 TRPA1 TRPM8

Drugs & Therapeutics for Photokeratitis

Search Clinical Trials , NIH Clinical Center for Photokeratitis

Genetic Tests for Photokeratitis

Anatomical Context for Photokeratitis

MalaCards organs/tissues related to Photokeratitis:

40
Eye, Skin

Publications for Photokeratitis

Articles related to Photokeratitis:

(show top 50) (show all 94)
# Title Authors PMID Year
1
Improper use of germicidal range ultraviolet lamp for household disinfection leading to phototoxicity in COVID-19 suspects. 61
32355114 2020
2
Nightclub Photokeratitis. 61
31973836 2020
3
Pain, Dryness, and Itch Sensations in Eye Surface Disorders Are Defined By a Balance Between Inflammation and Sensory Nerve Injury. 61
31490785 2019
4
Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo. 61
30926280 2019
5
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model. 61
30841522 2019
6
Maculopathy from an accidental exposure to welding arc. 61
30718265 2019
7
Photokeratitis among restaurant workers: A case series. 61
29998493 2018
8
Photokeratitis induced by ultraviolet radiation in travelers: A major health problem. 61
29067921 2018
9
Damaging Effects of Ultraviolet Radiation on the Cornea. 61
27935054 2017
10
Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. 61
29104724 2017
11
UVA1 a promising approach for scleroderma. 61
28979701 2017
12
Mass photokeratitis following ultraviolet light exposure at a nightclub. 61
26851136 2016
13
Photokeratitis Linked to Metal Halide Bulbs in Two Gymnasiums - Philadelphia, Pennsylvania, 2011 and 2013. 61
27010342 2016
14
Case series of keratitis in poultry abattoir workers induced by exposure to the ultraviolet disinfection lamp. 61
26779342 2016
15
Four Cases of Pediatric Photokeratitis Present to the Emergency Department After Watching the Same Theater Show. 61
27800238 2015
16
UV-blocking spectacle lens protects against UV-induced decline of visual performance. 61
26283865 2015
17
The enhancement of biological ocular UV radiation on beaches compared to the radiation on grass. 61
25463657 2014
18
Quantification of ocular biologically effective UV exposure for different rotation angle ranges based on data from a manikin. 61
24588689 2014
19
Ultraviolet light and ocular diseases. 61
23722672 2014
20
Action spectra affect variability of the climatology of biologically effective ultraviolet radiation on cloud-free days. 61
23843425 2013
21
Determination of a safe and effective ultraviolet B radiant dose in budgerigars (Melopsittacus undulatus): a pilot study. 61
24640928 2013
22
Balancing the risk of eye irritation from UV-C with infection from bioaerosols. 61
23668297 2013
23
The reversibility of UV-B induced alterations in optical properties of the rabbit cornea depends on dose of UV irradiation. 61
23106573 2013
24
The effect of ultraviolet radiation on the cornea - experimental study. 61
24399010 2013
25
Histological findings in the Wistar rat cornea following UVB irradiation. 61
23771066 2013
26
Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. 61
23340653 2013
27
Diurnal variation of ocular exposure to solar ultraviolet radiation based on data from a manikin head. 61
22268421 2012
28
High Altitude and the Eye. 61
26107334 2012
29
Central corneal thickness considered an index of corneal hydration of the UVB irradiated rabbit cornea as influenced by UVB absorber. 61
22480421 2012
30
Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops. 61
22393271 2012
31
Risk of eye damage from the wavelength-dependent biologically effective UVB spectrum irradiances. 61
23284960 2012
32
Ultraviolet light-induced cyclobutane pyrimidine dimers in rabbit eyes. 61
21770949 2011
33
Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression. 61
21494875 2011
34
An epidemiological perspective of ultraviolet exposure--public health concerns. 61
21670693 2011
35
The mechanisms and consequences of ultraviolet-induced immunosuppression in the skin and eye. 61
21709488 2011
36
Intraocular and crystalline lens protection from ultraviolet damage. 61
21670691 2011
37
Hydration and transparency of the rabbit cornea irradiated with UVB-doses of 0.25 J/cm(2) and 0.5 J/cm(2) compared with equivalent UVB radiation exposure reaching the human cornea from sunlight. 61
21599489 2011
38
A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo. 61
21421866 2011
39
Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation. 61
21527993 2011
40
Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro. 61
21921982 2011
41
Behavioral and neurophysiological correlates of nociception in an animal model of photokeratitis. 61
20417694 2010
42
A case-crossover study on transient risk factors of work-related eye injuries. 61
19286683 2009
43
A focus on ultraviolet keratitis. 61
28196007 2009
44
Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice. 61
18436209 2008
45
Ultraviolet radiation-induced corneal degeneration in 129 mice. 61
17943656 2007
46
Light absorption properties of the rabbit cornea repeatedly irradiated with UVB rays. 61
17576375 2007
47
Photokeratitis following the manipulation of aquaria disinfection lamps. 61
17351245 2007
48
Sunshine on holidays--eye risks. 61
17469750 2007
49
Acute effects of UVR on human eyes and skin. 61
16600340 2006
50
Unusual high exposure to ultraviolet-C radiation. 61
17205632 2006

Variations for Photokeratitis

Expression for Photokeratitis

Search GEO for disease gene expression data for Photokeratitis.

Pathways for Photokeratitis

GO Terms for Photokeratitis

Biological processes related to Photokeratitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 calcium ion transport GO:0006816 9.65 TRPV1 TRPM8 TRPA1
2 calcium ion transmembrane transport GO:0070588 9.61 TRPV1 TRPM8 TRPA1
3 response to oxidative stress GO:0006979 9.58 GPX8 GPX6 GPX5
4 negative regulation of neurogenesis GO:0050768 9.51 IL6 IL1B
5 cellular oxidant detoxification GO:0098869 9.5 GPX8 GPX6 GPX5
6 response to pain GO:0048265 9.49 TRPV1 TRPA1
7 positive regulation of glial cell proliferation GO:0060252 9.46 IL6 IL1B
8 positive regulation of neuroinflammatory response GO:0150078 9.37 IL6 IL1B
9 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.26 TRPV1 TRPA1
10 fever generation GO:0001660 9.16 TRPV1 IL1B
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.13 IL6 IL1B CXCL17
12 thermoception GO:0050955 8.8 TRPV1 TRPM8 TRPA1

Molecular functions related to Photokeratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 9.33 TRPV1 TRPM8 TRPA1
2 calcium-release channel activity GO:0015278 9.26 TRPV1 TRPA1
3 peroxidase activity GO:0004601 9.13 GPX8 GPX6 GPX5
4 glutathione peroxidase activity GO:0004602 8.8 GPX8 GPX6 GPX5

Sources for Photokeratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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