Aliases & Classifications for Photokeratitis

MalaCards integrated aliases for Photokeratitis:

Name: Photokeratitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13626
ICD10 33 H16.13
ICD9CM 35 370.24
NCIt 50 C118750
SNOMED-CT 68 1714005 193770007
UMLS 73 C0155078

Summaries for Photokeratitis

MalaCards based summary : Photokeratitis is related to pneumococcal meningitis and chronic venous leg ulcers. An important gene associated with Photokeratitis is TCF12 (Transcription Factor 12), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and PAK Pathway. Affiliated tissues include eye, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Photokeratitis or ultraviolet keratitis is a painful eye condition caused by exposure of insufficiently... more...

Related Diseases for Photokeratitis

Diseases related to Photokeratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 pneumococcal meningitis 10.7 MIF MMP9
2 chronic venous leg ulcers 10.6 FASLG MMP9
3 interdigitating dendritic cell sarcoma 10.6 CD163 PTPRC
4 diabetic foot ulcers 10.4 IL6 MMP9
5 histiocytic and dendritic cell cancer 10.4 CD163 PTPRC
6 central nervous system sarcoma 10.4 CD163 CD68
7 acute transverse myelitis 10.4 IL6 MMP9
8 adult xanthogranuloma 10.4 CD163 CD68
9 lymphoplasmacyte-rich meningioma 10.4 CD163 CD68
10 nodular tenosynovitis 10.4 CD68 PTPRC
11 extracutaneous mastocytoma 10.3 CD68 PTPRC
12 malignant giant cell tumor of soft parts 10.3 CD68 PTPRC
13 central nervous system tuberculosis 10.3 CD163 FASLG MMP9
14 spleen cancer 10.3 CD163 CD68
15 glomeruloid hemangioma 10.3 CD68 PTPRC
16 blepharochalasis 10.3 CD68 MMP9
17 sarcomatoid squamous cell skin carcinoma 10.2 CD68 PTPRC
18 petroclival meningioma 10.2 CD163 CD68
19 hodgkin's lymphoma, lymphocytic depletion 10.2 CD68 PTPRC
20 toxic myocarditis 10.1 JUN NOS3
21 internal hemorrhoid 10.1 HSPA4 MMP9
22 light chain deposition disease 10.1 CD68 MMP9
23 conventional fibrosarcoma 10.1 CD68 PTPRC
24 pertussis 10.1 FOS IL6 JUN
25 periosteal osteogenic sarcoma 10.1 FOS JUN
26 reticulohistiocytic granuloma 10.0 CD163 CD68 PTPRC
27 arteries, anomalies of 10.0 IL6 MMP9 NOS3
28 burns 9.9
29 brain sarcoma 9.7 CD163 CD68 JUN PTPRC
30 acute vascular insufficiency of intestine 9.7 HSPA4 IL6
31 angina pectoris 9.6 IL6 NOS3
32 rheumatoid arthritis 9.4 FOS IL6 JUN MIF MMP9
33 dendritic cell tumor 9.4 CD68 DNTT PTPRC
34 malaria 8.8 CD163 FASLG HSPA4 IL6 MIF MMP9
35 ewing sarcoma 7.7 DNTT FASLG HSPA4 IL6 JUN MMP9

Graphical network of the top 20 diseases related to Photokeratitis:



Diseases related to Photokeratitis

Symptoms & Phenotypes for Photokeratitis

MGI Mouse Phenotypes related to Photokeratitis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.27 CD163 CD68 DNTT IL6 FASLG JUN
2 immune system MP:0005387 10.22 CD163 CD68 DNTT IL6 FASLG JUN
3 cellular MP:0005384 10.19 FOS CD163 HSPA4 IL6 FASLG JUN
4 homeostasis/metabolism MP:0005376 10.17 FOS CD163 DNTT IL6 FASLG JUN
5 behavior/neurological MP:0005386 10.16 FOS HSPA4 IL6 NOS3 JUN OGN
6 endocrine/exocrine gland MP:0005379 10.08 FOS HSPA4 IL6 FASLG NOS3 JUN
7 nervous system MP:0003631 10.06 HSPA4 IL6 FASLG JUN FOS MIF
8 normal MP:0002873 9.86 FOS DNTT FASLG NOS3 JUN MIF
9 neoplasm MP:0002006 9.85 FOS IL6 FASLG MIF PTPRC MMP9
10 respiratory system MP:0005388 9.7 CD163 IL6 FASLG NOS3 JUN PTPRC
11 skeleton MP:0005390 9.56 FOS CD68 IL6 FASLG NOS3 JUN
12 vision/eye MP:0005391 9.23 FOS CD163 IL6 FASLG JUN OGN

Drugs & Therapeutics for Photokeratitis

Search Clinical Trials , NIH Clinical Center for Photokeratitis

Genetic Tests for Photokeratitis

Anatomical Context for Photokeratitis

MalaCards organs/tissues related to Photokeratitis:

41
Eye

Publications for Photokeratitis

Articles related to Photokeratitis:

(show all 20)
# Title Authors Year
1
Photokeratitis induced by ultraviolet radiation in travelers: A major health problem. ( 29067921 )
2018
2
Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. ( 29104724 )
2017
3
Photokeratitis Linked to Metal Halide Bulbs in Two Gymnasiums - Philadelphia, Pennsylvania, 2011 and 2013. ( 27010342 )
2016
4
Mass photokeratitis following ultraviolet light exposure at a nightclub. ( 26851136 )
2016
5
Four Cases of Pediatric Photokeratitis Present to the Emergency Department After Watching the Same Theater Show. ( 27800238 )
2015
6
Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. ( 23340653 )
2013
7
Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops. ( 22393271 )
2012
8
Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-I_B, iNOS, and TNF-I+ expression and reduction of MDA accumulation. ( 21527993 )
2011
9
Behavioral and neurophysiological correlates of nociception in an animal model of photokeratitis. ( 20417694 )
2010
10
Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice. ( 18436209 )
2008
11
Photokeratitis following the manipulation of aquaria disinfection lamps. ( 17351245 )
2007
12
Photokeratitis and UV-radiation burns associated with damaged metal halide lamps. ( 15066878 )
2004
13
Mass photokeratitis following exposure to unprotected ultraviolet light. ( 12848407 )
2003
14
Photokeratitis and other phototoxic effects on the cornea and conjunctiva. ( 12537642 )
2002
15
Photokeratitis from subablative 193-nanometer excimer laser radiation. ( 1390406 )
1992
16
Photokeratitis from 193 nm argon-fluoride laser radiation. ( 1886933 )
1991
17
Corneal damage in photokeratitis--why is it so painful? ( 2381684 )
1990
18
Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis. ( 2383204 )
1990
19
Photokeratitis: laboratory versus solar exposure. ( 3182210 )
1988
20
Light penetration of normal and photokeratitis induced rabbit cornea. ( 6720295 )
1984

Variations for Photokeratitis

Expression for Photokeratitis

Search GEO for disease gene expression data for Photokeratitis.

Pathways for Photokeratitis

Pathways related to Photokeratitis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 FOS HSPA4 IL6 JUN NOS3 OGN
2
Show member pathways
13.16 FASLG FOS IL6 JUN OGN PTPRC
3
Show member pathways
12.95 FASLG FOS JUN MMP9 NOS3
4
Show member pathways
12.8 FASLG FOS HSPA4 IL6 PTPRC
5
Show member pathways
12.79 FASLG IL6 JUN MMP9 PTPRC
6 12.75 FASLG FOS IL6 JUN MMP9
7
Show member pathways
12.51 FOS JUN NOS3 PTPRC
8
Show member pathways
12.47 FOS IL6 JUN NOS3
9
Show member pathways
12.43 FASLG FOS IL6 JUN MMP9
10
Show member pathways
12.36 FOS IL6 JUN PTPRC
11
Show member pathways
12.25 FOS IL6 JUN MMP9
12
Show member pathways
12.16 FOS IL6 JUN MIF
13
Show member pathways
12 FOS IL6 JUN OGN
14 11.97 FOS JUN MMP9 NOS3
15
Show member pathways
11.96 IL6 JUN NOS3
16
Show member pathways
11.91 FASLG FOS JUN
17 11.86 FOS IL6 MIF MMP9
18 11.84 IL6 JUN NOS3
19 11.82 CD163 CD68 IL6 PTPRC
20 11.79 FOS IL6 JUN
21 11.79 FASLG FOS IL6 MMP9
22
Show member pathways
11.77 FOS IL6 JUN
23 11.77 FOS IL6 JUN
24 11.74 FOS IL6 JUN
25 11.74 FOS IL6 JUN MMP9
26
Show member pathways
11.7 FASLG FOS JUN
27 11.69 FOS IL6 JUN
28 11.68 CD163 IL6 PTPRC
29 11.62 JUN MMP9 NOS3
30
Show member pathways
11.57 FASLG FOS JUN
31 11.51 FOS IL6 JUN
32 11.48 FASLG IL6 JUN
33 11.48 FOS IL6 JUN MMP9
34
Show member pathways
11.46 FOS HSPA4 JUN
35 11.42 FOS JUN MMP9
36
Show member pathways
11.39 FOS JUN MMP9
37 11.33 FOS HSPA4 JUN
38 11.27 FASLG FOS IL6 JUN
39 11.19 FOS IL6 JUN
40 11.11 FASLG FOS IL6 JUN
41 11.08 MMP9 NOS3
42 11.08 FOS JUN
43 11.06 FOS JUN
44 11.06 FOS JUN
45 11.04 FOS JUN
46
Show member pathways
10.82 FOS IL6 JUN MIF MMP9
47 10.79 IL6 JUN MMP9 NOS3
48 10.58 FOS JUN MIF

GO Terms for Photokeratitis

Cellular components related to Photokeratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.46 DNTT JUN TCF12 USF1
2 transcription factor complex GO:0005667 9.26 FOS JUN TCF12 USF1
3 transcription factor AP-1 complex GO:0035976 8.62 FOS JUN

Biological processes related to Photokeratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 CD163 FOS IL6 MIF
2 positive regulation of apoptotic process GO:0043065 9.71 FASLG IL6 JUN MMP9
3 positive regulation of transcription, DNA-templated GO:0045893 9.65 FOS IL6 JUN TCF12 USF1
4 cytokine-mediated signaling pathway GO:0019221 9.62 FASLG FOS IL6 MMP9
5 response to lipopolysaccharide GO:0032496 9.46 FASLG FOS JUN NOS3
6 response to muscle stretch GO:0035994 9.37 FOS JUN
7 cellular response to reactive oxygen species GO:0034614 9.13 FOS JUN MMP9
8 cellular response to cadmium ion GO:0071276 8.8 FOS JUN MMP9

Molecular functions related to Photokeratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.71 FOS JUN TCF12 USF1
2 R-SMAD binding GO:0070412 9.43 FOS JUN
3 double-stranded DNA binding GO:0003690 9.43 FOS JUN USF1
4 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.37 FOS JUN
5 HMG box domain binding GO:0071837 9.32 JUN TCF12
6 cAMP response element binding GO:0035497 8.96 JUN TCF12
7 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 8.92 FOS JUN TCF12 USF1
8 protein binding GO:0005515 10 CD163 DNTT FASLG FOS HSPA4 IL6

Sources for Photokeratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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