MCID: PHT002
MIFTS: 27

Photokeratitis

Categories: Neuronal diseases

Aliases & Classifications for Photokeratitis

MalaCards integrated aliases for Photokeratitis:

Name: Photokeratitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13626
ICD9CM 34 370.24
NCIt 50 C118750
SNOMED-CT 67 1714005
ICD10 32 H16.13
UMLS 70 C0155078

Summaries for Photokeratitis

MalaCards based summary : Photokeratitis is related to keratitis, hereditary and facial dermatosis. An important gene associated with Photokeratitis is RNGTT (RNA Guanylyltransferase And 5'-Phosphatase), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Cellular Senescence (REACTOME). Affiliated tissues include eye and skin, and related phenotype is integument.

Wikipedia : 73 Photokeratitis or ultraviolet keratitis is a painful eye condition caused by exposure of insufficiently... more...

Related Diseases for Photokeratitis

Diseases related to Photokeratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.2
2 facial dermatosis 10.1 TRPV1 TRPA1
3 pseudopterygium 10.1 TRPV1 TRPA1
4 autonomic nervous system disease 10.0 TRPV1 TRPA1
5 dental pulp disease 10.0 TRPV1 IL1B
6 hyperhidrosis, gustatory 10.0 TRPV1 TRPM8 TRPA1
7 dentin sensitivity 10.0 TRPV1 TRPM8 TRPA1
8 trigeminal nerve disease 10.0 TRPV1 TRPM8 TRPA1
9 trigeminal neuralgia 10.0 TRPV1 TRPM8 TRPA1
10 mutilating palmoplantar keratoderma with periorificial keratotic plaques 10.0 TRPV1 TRPM8 TRPA1
11 familial episodic pain syndrome 10.0 TRPV1 TRPM8 TRPA1
12 burning mouth syndrome 10.0 TRPV1 IL1B
13 paroxysmal extreme pain disorder 10.0 TRPV1 TRPM8 TRPA1
14 erythromelalgia 10.0 TRPV1 TRPA1
15 lacrimal apparatus disease 9.9 TRPM8 IL1B
16 ifap syndrome 2 9.9
17 keratopathy 9.9
18 corneal ulcer 9.9
19 climatic droplet keratopathy 9.9
20 pulpitis 9.9 TRPV1 IL1B
21 irritable bowel syndrome 9.9 TRPV1 TRPA1 IL1B
22 erysipelas 9.8 IL1B CAT
23 somatoform disorder 9.7 TRPV1 TRPM8 TRPA1 IL1B
24 pain agnosia 9.7 TRPV1 TRPM8 TRPA1 IL1B
25 agnosia 9.7 TRPV1 TRPM8 TRPA1 IL1B
26 paine syndrome 9.7 TRPV1 TRPM8 TRPA1 IL1B
27 migraine with or without aura 1 9.7 TRPV1 TRPM8 TRPA1 IL1B
28 peripheral nervous system disease 9.7 TRPV1 TRPM8 TRPA1 IL1B
29 anemia, nonspherocytic hemolytic, due to g6pd deficiency 9.6 GPX8 GPX6 GPX5
30 aseptic meningitis 9.6 IL1B CAT

Graphical network of the top 20 diseases related to Photokeratitis:



Diseases related to Photokeratitis

Symptoms & Phenotypes for Photokeratitis

MGI Mouse Phenotypes related to Photokeratitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 CXCL17 GPX8 IL1B TRPA1 TRPM8 TRPV1

Drugs & Therapeutics for Photokeratitis

Search Clinical Trials , NIH Clinical Center for Photokeratitis

Genetic Tests for Photokeratitis

Anatomical Context for Photokeratitis

MalaCards organs/tissues related to Photokeratitis:

40
Eye, Skin

Publications for Photokeratitis

Articles related to Photokeratitis:

(show top 50) (show all 98)
# Title Authors PMID Year
1
Improper Use of the Germicidal Range Ultraviolet Lamp for Household Disinfection Leading to Phototoxicity in COVID-19 Suspects. 61
32355114 2021
2
Mass photokeratitis in coronary angiography medical staff following exposure to unprotected ultraviolet light. 61
33514456 2021
3
UV-Photokeratitis Associated with Germicidal Lamps Purchased during the COVID-19 Pandemic. 61
33215961 2021
4
An outbreak of bilateral photokeratitis and eyelid erythema following exposure to an artificial source of ultraviolet radiation, Tamil Nadu, India, 2018. 61
33778353 2020
5
Nightclub Photokeratitis. 61
31973836 2020
6
[Keratoconjunctivitis photoelectrica (arc eye)]. 61
32774618 2020
7
Pain, Dryness, and Itch Sensations in Eye Surface Disorders Are Defined By a Balance Between Inflammation and Sensory Nerve Injury. 61
31490785 2019
8
Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo. 61
30926280 2019
9
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model. 61
30841522 2019
10
Maculopathy from an accidental exposure to welding arc. 61
30718265 2019
11
Photokeratitis among restaurant workers: A case series. 61
29998493 2018
12
Photokeratitis induced by ultraviolet radiation in travelers: A major health problem. 61
29067921 2018
13
Damaging Effects of Ultraviolet Radiation on the Cornea. 61
27935054 2017
14
Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. 61
29104724 2017
15
UVA1 a promising approach for scleroderma. 61
28979701 2017
16
Mass photokeratitis following ultraviolet light exposure at a nightclub. 61
26851136 2016
17
Photokeratitis Linked to Metal Halide Bulbs in Two Gymnasiums - Philadelphia, Pennsylvania, 2011 and 2013. 61
27010342 2016
18
Case series of keratitis in poultry abattoir workers induced by exposure to the ultraviolet disinfection lamp. 61
26779342 2016
19
Four Cases of Pediatric Photokeratitis Present to the Emergency Department After Watching the Same Theater Show. 61
27800238 2015
20
UV-blocking spectacle lens protects against UV-induced decline of visual performance. 61
26283865 2015
21
The enhancement of biological ocular UV radiation on beaches compared to the radiation on grass. 61
25463657 2014
22
Quantification of ocular biologically effective UV exposure for different rotation angle ranges based on data from a manikin. 61
24588689 2014
23
Ultraviolet light and ocular diseases. 61
23722672 2014
24
Determination of a safe and effective ultraviolet B radiant dose in budgerigars (Melopsittacus undulatus): a pilot study. 61
24640928 2013
25
Action spectra affect variability of the climatology of biologically effective ultraviolet radiation on cloud-free days. 61
23843425 2013
26
Balancing the risk of eye irritation from UV-C with infection from bioaerosols. 61
23668297 2013
27
The reversibility of UV-B induced alterations in optical properties of the rabbit cornea depends on dose of UV irradiation. 61
23106573 2013
28
Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. 61
23340653 2013
29
The effect of ultraviolet radiation on the cornea - experimental study. 61
24399010 2013
30
Histological findings in the Wistar rat cornea following UVB irradiation. 61
23771066 2013
31
High Altitude and the Eye. 61
26107334 2012
32
Diurnal variation of ocular exposure to solar ultraviolet radiation based on data from a manikin head. 61
22268421 2012
33
Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops. 61
22393271 2012
34
Central corneal thickness considered an index of corneal hydration of the UVB irradiated rabbit cornea as influenced by UVB absorber. 61
22480421 2012
35
Risk of eye damage from the wavelength-dependent biologically effective UVB spectrum irradiances. 61
23284960 2012
36
Ultraviolet light-induced cyclobutane pyrimidine dimers in rabbit eyes. 61
21770949 2011
37
Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression. 61
21494875 2011
38
Hydration and transparency of the rabbit cornea irradiated with UVB-doses of 0.25 J/cm(2) and 0.5 J/cm(2) compared with equivalent UVB radiation exposure reaching the human cornea from sunlight. 61
21599489 2011
39
Intraocular and crystalline lens protection from ultraviolet damage. 61
21670691 2011
40
An epidemiological perspective of ultraviolet exposure--public health concerns. 61
21670693 2011
41
The mechanisms and consequences of ultraviolet-induced immunosuppression in the skin and eye. 61
21709488 2011
42
A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo. 61
21421866 2011
43
Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation. 61
21527993 2011
44
Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro. 61
21921982 2011
45
Behavioral and neurophysiological correlates of nociception in an animal model of photokeratitis. 61
20417694 2010
46
A case-crossover study on transient risk factors of work-related eye injuries. 61
19286683 2009
47
A focus on ultraviolet keratitis. 61
28196007 2009
48
Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice. 61
18436209 2008
49
Ultraviolet radiation-induced corneal degeneration in 129 mice. 61
17943656 2007
50
Light absorption properties of the rabbit cornea repeatedly irradiated with UVB rays. 61
17576375 2007

Variations for Photokeratitis

Expression for Photokeratitis

Search GEO for disease gene expression data for Photokeratitis.

Pathways for Photokeratitis

Pathways related to Photokeratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 IL1B GPX8 GPX6 GPX5 CAT
2
Show member pathways
12.71 GPX8 GPX6 GPX5 CAT
3
Show member pathways
12.1 TRPV1 TRPM8 TRPA1
4
Show member pathways
11.88 IL1B GPX6 CAT
5
Show member pathways
11.81 GPX8 GPX6 GPX5
6
Show member pathways
11.74 TRPV1 TRPM8 TRPA1 IL1B
7
Show member pathways
11.49 GPX8 GPX6 GPX5
8
Show member pathways
10.66 GPX8 GPX6 GPX5 CAT
9 10.53 TRPV1 TRPM8 TRPA1

GO Terms for Photokeratitis

Biological processes related to Photokeratitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.84 GPX8 GPX6 GPX5 CAT
2 ion transmembrane transport GO:0034220 9.74 TRPV1 TRPM8 TRPA1
3 calcium ion transport GO:0006816 9.63 TRPV1 TRPM8 TRPA1
4 cellular response to growth factor stimulus GO:0071363 9.59 TRPV1 CAT
5 response to hydrogen peroxide GO:0042542 9.58 TRPA1 CAT
6 protein homotetramerization GO:0051289 9.58 TRPV1 TRPA1
7 calcium ion transmembrane transport GO:0070588 9.58 TRPV1 TRPM8 TRPA1
8 sensory perception of pain GO:0019233 9.56 TRPV1 TRPA1
9 positive regulation of cell division GO:0051781 9.55 IL1B CAT
10 cellular response to oxidative stress GO:0034599 9.54 GPX8 GPX5 CAT
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.52 TRPV1 IL1B
12 release of sequestered calcium ion into cytosol GO:0051209 9.51 TRPV1 TRPA1
13 response to cold GO:0009409 9.49 TRPM8 TRPA1
14 positive regulation of vascular endothelial growth factor production GO:0010575 9.48 IL1B CXCL17
15 response to oxidative stress GO:0006979 9.46 GPX8 GPX6 GPX5 CAT
16 response to pain GO:0048265 9.43 TRPV1 TRPA1
17 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.32 TRPV1 TRPA1
18 fever generation GO:0001660 9.26 TRPV1 IL1B
19 cellular oxidant detoxification GO:0098869 9.26 GPX8 GPX6 GPX5 CAT
20 thermoception GO:0050955 8.8 TRPV1 TRPM8 TRPA1

Molecular functions related to Photokeratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.67 GPX8 GPX6 GPX5 CAT
2 ion channel activity GO:0005216 9.5 TRPV1 TRPM8 TRPA1
3 cation channel activity GO:0005261 9.4 TRPV1 TRPM8
4 calcium channel activity GO:0005262 9.33 TRPV1 TRPM8 TRPA1
5 calcium-release channel activity GO:0015278 9.26 TRPV1 TRPA1
6 glutathione peroxidase activity GO:0004602 9.13 GPX8 GPX6 GPX5
7 peroxidase activity GO:0004601 8.92 GPX8 GPX6 GPX5 CAT

Sources for Photokeratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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