PSE
MCID: PHT008
MIFTS: 36

Photosensitive Epilepsy (PSE)

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Photosensitive Epilepsy

MalaCards integrated aliases for Photosensitive Epilepsy:

Name: Photosensitive Epilepsy 12 76 53 59 15
Reflex Epilepsy, Photosensitive 73
Photoparoxysmal Response 1 73
Photoparoxysmal Response 12
Photogenic Epilepsy 12
Pse 53

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0060281
ICD10 33 G40.8
Orphanet 59 ORPHA166409
UMLS via Orphanet 74 C0393720

Summaries for Photosensitive Epilepsy

Disease Ontology : 12 An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights.

MalaCards based summary : Photosensitive Epilepsy, also known as reflex epilepsy, photosensitive, is related to photoparoxysmal response 1 and photoparoxysmal response 2. An important gene associated with Photosensitive Epilepsy is PPR1 (Photoparoxysmal Response 1). The drugs Valproic Acid and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotype is vision/eye.

Wikipedia : 76 Photosensitive epilepsy (PSE) is a form of epilepsy in which seizures are triggered by visual stimuli... more...

Related Diseases for Photosensitive Epilepsy

Graphical network of the top 20 diseases related to Photosensitive Epilepsy:



Diseases related to Photosensitive Epilepsy

Symptoms & Phenotypes for Photosensitive Epilepsy

MGI Mouse Phenotypes related to Photosensitive Epilepsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 BRD2 CHD2 CLN6 GJA8 NEDD4L

Drugs & Therapeutics for Photosensitive Epilepsy

Drugs for Photosensitive Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
2 Central Nervous System Depressants Phase 4,Phase 2
3 Tranquilizing Agents Phase 4,Phase 2
4 Psychotropic Drugs Phase 4,Phase 2
5 Antimanic Agents Phase 4,Phase 2
6 Anticonvulsants Phase 4,Phase 2
7 GABA Agents Phase 4,Phase 2
8 Neurotransmitter Agents Phase 4,Phase 2
9
Brivaracetam Approved, Investigational Phase 2, Phase 3 357336-20-0 9837243
10 Etiracetam Investigational Phase 2, Phase 3 33996-58-6
11
Carbamazepine Approved, Investigational Phase 2 298-46-4 2554
12
Lorazepam Approved Phase 2 846-49-1 3958
13
Alprazolam Approved, Illicit, Investigational Phase 2 28981-97-7 2118
14 Cytochrome P-450 CYP3A Inducers Phase 2
15 Peripheral Nervous System Agents Phase 2
16 Analgesics Phase 2
17 Analgesics, Non-Narcotic Phase 2
18 Nootropic Agents Phase 2
19 Anti-Anxiety Agents Phase 2
20 GABA Modulators Phase 2
21 Autonomic Agents Phase 2
22 Gastrointestinal Agents Phase 2
23 Antiemetics Phase 2
24 Hypnotics and Sedatives Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Effect of Valproic Acid Concentration on Photic Response Completed NCT00609245 Phase 4 Valproic Acid;Placebo
2 Does BRV Have Faster Onset Time & Greater Effect Than LEV in Epilepsy Pts Using PPR Pharmacodynamic Efficacy Endpoint Recruiting NCT03580707 Phase 2, Phase 3 BRV vs LEV in randomized double blinded, crossover fashion
3 Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25). Not yet recruiting NCT03790137 Phase 3 Fenfluramine Hydrochloride
4 Effect of BGG492 on EEG in Patients With Photosensitive Epilepsy Completed NCT00784212 Phase 2 BGG492;BGG492;Placebo
5 A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients Completed NCT03239691 Phase 2 ACT-709478 for oral use;Placebo
6 A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy Completed NCT00579384 Phase 2 JNJ-26489112;Placebo
7 Photosensitivity Proof of Concept Trial Completed NCT00894010 Phase 2 carbamazepine 400mg;levetiracetam 1000mg
8 PF-06372865 in Subjects With Photosensitive Epilepsy Completed NCT02564029 Phase 2 PF-06372865;Placebo;Lorazepam
9 Efficacy of YKP3089 in Patients With Photosensitive Epilepsy Completed NCT00616148 Phase 2 YKP3089;Placebo
10 Staccato Alprazolam and Photoparoxysmal Response Completed NCT02351115 Phase 2 Staccato® Alprazolam, 0.5 mg;Staccato® Alprazolam, 1 mg;Staccato® Alprazolam, 2 mg;Staccato® Placebo (a);Staccato® Placebo (b)
11 A Study to Evaluate the Pharmacodynamic Activity of E2082 in Adult Participants With Photosensitive Epilepsy Recruiting NCT03686033 Phase 2 Placebo;E2082
12 A Study to Evaluate the Pharmacodynamic Activity of E2730 in Adult Participants With Photosensitive Epilepsy Terminated NCT03603639 Phase 2 Placebo;E2730
13 A Study to Investigate the Effect of ICA-105665 in Photosensitive Epilepsy Patients Terminated NCT00979004 Phase 2 ICA-105665

Search NIH Clinical Center for Photosensitive Epilepsy

Genetic Tests for Photosensitive Epilepsy

Anatomical Context for Photosensitive Epilepsy

MalaCards organs/tissues related to Photosensitive Epilepsy:

41
Eye, Brain, Testes, Retina, Skin

Publications for Photosensitive Epilepsy

Articles related to Photosensitive Epilepsy:

(show top 50) (show all 114)
# Title Authors Year
1
Clinical advances in photosensitive epilepsy. ( 30076791 )
2018
2
Gamma oscillations and photosensitive epilepsy. ( 28486114 )
2017
3
Photosensitive epilepsy is associated with reduced inhibition of alpha rhythm generating networks. ( 28334965 )
2017
4
Multi-modal imaging and photosensitive epilepsy: a link between resting brain rhythms and seizure genesis. ( 28375460 )
2017
5
Altered recovery from inhibitory repetitive transcranial magnetic stimulation (rTMS) in subjects with photosensitive epilepsy. ( 27407061 )
2016
6
Single dose efficacy evaluation of two partial benzodiazepine receptor agonists in photosensitive epilepsy patients: A placebo-controlled pilot study. ( 26921854 )
2016
7
Myoclonic occipital photosensitive epilepsy with dystonia (MOPED): A familial epilepsy syndrome. ( 26088892 )
2015
8
Valproate in adolescents with photosensitive epilepsy with generalized tonic-clonic seizures only. ( 23891468 )
2014
9
How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? ( 24745323 )
2014
10
Epileptic spasms and early-onset photosensitive epilepsy in Patau syndrome: An EEG study. ( 25459971 )
2014
11
Investigation of the possible association of NEDD4-2 (NEDD4L) gene with idiopathic photosensitive epilepsy. ( 25542253 )
2014
12
Comment from DorothAce G.A. Kasteleijn-Nolst TrenitAc, Edouard Hirsch, Ronald C. Reed, Bassel Abou-Khalil, and Bernd Schmidt on: How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? ( 25201046 )
2014
13
Impaired white-matter integrity in photosensitive epilepsy: a DTI study using tract-based spatial statistics. ( 24524870 )
2014
14
Evaluation of JNJ-26489112 in patients with photosensitive epilepsy: a placebo-controlled, exploratory study. ( 24560845 )
2014
15
Evidence for increased visual gamma responses in photosensitive epilepsy. ( 24893831 )
2014
16
Bromodomain-containing protein 2 gene in photosensitive epilepsy. ( 22766109 )
2012
17
3D movies and risk of seizures in patients with photosensitive epilepsy. ( 21937246 )
2012
18
Abnormal visual habituation in pediatric photosensitive epilepsy. ( 20591728 )
2011
19
Clinical response to methylphenidate in a patient with self-induced photosensitive epilepsy. ( 21427445 )
2011
20
Transition to seizure in photosensitive epilepsy. ( 22071550 )
2011
21
Diagnosing photosensitive epilepsy: fancy new versus old fashioned techniques in patients with different epileptic syndromes. ( 20615639 )
2011
22
Photosensitive epilepsy in India. ( 21192524 )
2010
23
Photosensitive epilepsy: spectral and coherence analyses of EEG using 14Hz intermittent photic stimulation. ( 20071221 )
2010
24
Photosensitive epilepsy and image safety. ( 18930180 )
2010
25
Dynamic effects and information quantifiers of statistical memory of MEG's signals at photosensitive epilepsy. ( 19292515 )
2009
26
Wind turbines, flicker, and photosensitive epilepsy: characterizing the flashing that may precipitate seizures and optimizing guidelines to prevent them. ( 18397297 )
2008
27
Is photosensitive epilepsy less common in males due to variation in X chromosome photopigment genes? ( 17521342 )
2007
28
Reasons to consider a plasma screen television--photosensitive epilepsy. ( 17922779 )
2007
29
Suppressive efficacy by a commercially available blue lens on PPR in 610 photosensitive epilepsy patients. ( 16529617 )
2006
30
Monozygous twin brothers discordant for photosensitive epilepsy: first report of possible visual priming in humans. ( 16146452 )
2005
31
Ocular defects in photosensitive epilepsy. ( 15105955 )
2004
32
Efficacy of sodium valproate in the treatment of photosensitive epilepsy (PSE) and the probable reasons for the persistence of occipital spikes. ( 15311327 )
2004
33
The reflex epilepsies with emphasis on photosensitive epilepsy. ( 16106643 )
2004
34
A novel nonpharmacologic treatment for photosensitive epilepsy: a report of three patients tested with blue cross-polarized glasses. ( 15329083 )
2004
35
Self induced photosensitive epilepsy. ( 15280616 )
2004
36
Paroxysmal eyelid movements: a confusing feature of generalized photosensitive epilepsy. ( 15249608 )
2004
37
Gamma-band phase clustering and photosensitivity: is there an underlying mechanism common to photosensitive epilepsy and visual perception? ( 12690055 )
2003
38
Photosensitive epilepsy beyond adolescence: is freedom from photosensitivity age-dependent? ( 12955814 )
2003
39
Near reflex accommodation spasm: unusual presentation of generalized photosensitive epilepsy. ( 12383431 )
2002
40
Refractory photosensitive epilepsy associated with a complex rearrangement of chromosome 2. ( 12571788 )
2002
41
PokAcmon contagion: photosensitive epilepsy or mass psychogenic illness? ( 11235034 )
2001
42
Cross polarized spectacles in photosensitive epilepsy. ( 11759770 )
2001
43
Lack of cortical contrast gain control in human photosensitive epilepsy. ( 10700258 )
2000
44
A case of comorbidity between panic disorder and photosensitive epilepsy. ( 10965285 )
2000
45
Brain activation during intermittent photic stimulation: a [15O]-water PET study on photosensitive epilepsy. ( 10487168 )
1999
46
Treatment of photosensitive epilepsy using coloured glasses. ( 10627405 )
1999
47
Clinical significance of EEG abnormalities during photic stimulation in patients with photosensitive epilepsy. ( 10080521 )
1999
48
Photosensitive epilepsy studied by functional magnetic resonance imaging and magnetic resonance spectroscopy. ( 10487166 )
1999
49
Televised material and photosensitive epilepsy. ( 10487176 )
1999
50
Evaluation of the laboratory and environmental factors that induce seizures in photosensitive epilepsy. ( 10427355 )
1999

Variations for Photosensitive Epilepsy

Expression for Photosensitive Epilepsy

Search GEO for disease gene expression data for Photosensitive Epilepsy.

Pathways for Photosensitive Epilepsy

GO Terms for Photosensitive Epilepsy

Biological processes related to Photosensitive Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter transport GO:0006836 8.62 SLC6A18 SV2A

Sources for Photosensitive Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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