MCID: PHT008
MIFTS: 34

Photosensitive Epilepsy

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Photosensitive Epilepsy

MalaCards integrated aliases for Photosensitive Epilepsy:

Name: Photosensitive Epilepsy 12 76 53 59 15
Reflex Epilepsy, Photosensitive 73
Photoparoxysmal Response 1 73
Photoparoxysmal Response 12
Photogenic Epilepsy 12
Pse 53

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0060281
ICD10 33 G40.8
Orphanet 59 ORPHA166409
UMLS via Orphanet 74 C0393720

Summaries for Photosensitive Epilepsy

Disease Ontology : 12 An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights.

MalaCards based summary : Photosensitive Epilepsy, also known as reflex epilepsy, photosensitive, is related to photoparoxysmal response 1 and photoparoxysmal response 2. An important gene associated with Photosensitive Epilepsy is PPR3 (Photoparoxysmal Response 3). The drugs Valproic Acid and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and retina.

Wikipedia : 76 Photosensitive epilepsy (PSE) is a form of epilepsy in which seizures are triggered by visual stimuli... more...

Related Diseases for Photosensitive Epilepsy

Diseases related to Photosensitive Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 photoparoxysmal response 1 33.9 IER3IP1 PPR1
2 photoparoxysmal response 2 12.2
3 photoparoxysmal response 3 12.2
4 peeling skin syndrome 1 10.9
5 chd2 myoclonic encephalopathy 10.9
6 epilepsy 10.8
7 encephalopathy 10.1
8 reflex epilepsy 10.0
9 adolescence-adult electroclinical syndrome 10.0 BRD2 GJA8
10 hepatitis 10.0
11 hepatic encephalopathy 10.0
12 epilepsy, idiopathic generalized 10 9.9 BRD2 GJA8
13 breast cancer 9.8
14 portal hypertension 9.8
15 aging 9.8
16 accommodative spasm 9.8
17 patau syndrome 9.8
18 retinitis 9.8
19 dystonia 9.8
20 panic disorder 9.8
21 epilepsy with generalized tonic-clonic seizures 9.8
22 benign epilepsy with centrotemporal spikes 9.7 CHD2 IER3IP1

Graphical network of the top 20 diseases related to Photosensitive Epilepsy:



Diseases related to Photosensitive Epilepsy

Symptoms & Phenotypes for Photosensitive Epilepsy

Drugs & Therapeutics for Photosensitive Epilepsy

Drugs for Photosensitive Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
2 Anticonvulsants Phase 4,Phase 2
3 Antimanic Agents Phase 4,Phase 2
4 Central Nervous System Depressants Phase 4,Phase 2
5 GABA Agents Phase 4,Phase 2
6 Neurotransmitter Agents Phase 4,Phase 2
7 Psychotropic Drugs Phase 4,Phase 2
8 Tranquilizing Agents Phase 4,Phase 2
9
Carbamazepine Approved, Investigational Phase 2 298-46-4 2554
10
Lorazepam Approved Phase 2 846-49-1 3958
11
Alprazolam Approved, Illicit, Investigational Phase 2 28981-97-7 2118
12 Etiracetam Investigational Phase 2 33996-58-6
13 Analgesics Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Cytochrome P-450 CYP3A Inducers Phase 2
16 Nootropic Agents Phase 2
17 Peripheral Nervous System Agents Phase 2
18 Anti-Anxiety Agents Phase 2
19 Antiemetics Phase 2
20 Autonomic Agents Phase 2
21 GABA Modulators Phase 2
22 Gastrointestinal Agents Phase 2
23 Hypnotics and Sedatives Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Valproic Acid Concentration on Photic Response Completed NCT00609245 Phase 4 Valproic Acid;Placebo
2 Does BRV Have Faster Onset Time & Greater Effect Than LEV in Epilepsy Pts Using PPR Pharmacodynamic Efficacy Endpoint Recruiting NCT03580707 Phase 2, Phase 3 BRV vs LEV in randomized double blinded, crossover fashion
3 Effect of BGG492 on EEG in Patients With Photosensitive Epilepsy Completed NCT00784212 Phase 2 BGG492;BGG492;Placebo
4 A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy Completed NCT00579384 Phase 2 JNJ-26489112;Placebo
5 Photosensitivity Proof of Concept Trial Completed NCT00894010 Phase 2 carbamazepine 400mg;levetiracetam 1000mg
6 PF-06372865 in Subjects With Photosensitive Epilepsy Completed NCT02564029 Phase 2 PF-06372865;Placebo;Lorazepam
7 Efficacy of YKP3089 in Patients With Photosensitive Epilepsy Completed NCT00616148 Phase 2 YKP3089;Placebo
8 Staccato Alprazolam and Photoparoxysmal Response Completed NCT02351115 Phase 2 Staccato® Alprazolam, 0.5 mg;Staccato® Alprazolam, 1 mg;Staccato® Alprazolam, 2 mg;Staccato® Placebo (a);Staccato® Placebo (b)
9 A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients Recruiting NCT03239691 Phase 2 ACT-709478 for oral use;Placebo
10 A Study to Investigate the Effect of ICA-105665 in Photosensitive Epilepsy Patients Terminated NCT00979004 Phase 2 ICA-105665

Search NIH Clinical Center for Photosensitive Epilepsy

Genetic Tests for Photosensitive Epilepsy

Anatomical Context for Photosensitive Epilepsy

MalaCards organs/tissues related to Photosensitive Epilepsy:

41
Brain, Testes, Retina, Eye

Publications for Photosensitive Epilepsy

Articles related to Photosensitive Epilepsy:

(show top 50) (show all 112)
# Title Authors Year
1
Gamma oscillations and photosensitive epilepsy. ( 28486114 )
2017
2
Photosensitive epilepsy is associated with reduced inhibition of alpha rhythm generating networks. ( 28334965 )
2017
3
Multi-modal imaging and photosensitive epilepsy: a link between resting brain rhythms and seizure genesis. ( 28375460 )
2017
4
Altered recovery from inhibitory repetitive transcranial magnetic stimulation (rTMS) in subjects with photosensitive epilepsy. ( 27407061 )
2016
5
Single dose efficacy evaluation of two partial benzodiazepine receptor agonists in photosensitive epilepsy patients: A placebo-controlled pilot study. ( 26921854 )
2016
6
Myoclonic occipital photosensitive epilepsy with dystonia (MOPED): A familial epilepsy syndrome. ( 26088892 )
2015
7
Valproate in adolescents with photosensitive epilepsy with generalized tonic-clonic seizures only. ( 23891468 )
2014
8
How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? ( 24745323 )
2014
9
Epileptic spasms and early-onset photosensitive epilepsy in Patau syndrome: An EEG study. ( 25459971 )
2014
10
Investigation of the possible association of NEDD4-2 (NEDD4L) gene with idiopathic photosensitive epilepsy. ( 25542253 )
2014
11
Comment from DorothAce G.A. Kasteleijn-Nolst TrenitAc, Edouard Hirsch, Ronald C. Reed, Bassel Abou-Khalil, and Bernd Schmidt on: How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? ( 25201046 )
2014
12
Impaired white-matter integrity in photosensitive epilepsy: a DTI study using tract-based spatial statistics. ( 24524870 )
2014
13
Evaluation of JNJ-26489112 in patients with photosensitive epilepsy: a placebo-controlled, exploratory study. ( 24560845 )
2014
14
Evidence for increased visual gamma responses in photosensitive epilepsy. ( 24893831 )
2014
15
Bromodomain-containing protein 2 gene in photosensitive epilepsy. ( 22766109 )
2012
16
3D movies and risk of seizures in patients with photosensitive epilepsy. ( 21937246 )
2012
17
Abnormal visual habituation in pediatric photosensitive epilepsy. ( 20591728 )
2011
18
Clinical response to methylphenidate in a patient with self-induced photosensitive epilepsy. ( 21427445 )
2011
19
Transition to seizure in photosensitive epilepsy. ( 22071550 )
2011
20
Diagnosing photosensitive epilepsy: fancy new versus old fashioned techniques in patients with different epileptic syndromes. ( 20615639 )
2011
21
Photosensitive epilepsy in India. ( 21192524 )
2010
22
Photosensitive epilepsy: spectral and coherence analyses of EEG using 14Hz intermittent photic stimulation. ( 20071221 )
2010
23
Photosensitive epilepsy and image safety. ( 18930180 )
2010
24
Dynamic effects and information quantifiers of statistical memory of MEG's signals at photosensitive epilepsy. ( 19292515 )
2009
25
Wind turbines, flicker, and photosensitive epilepsy: characterizing the flashing that may precipitate seizures and optimizing guidelines to prevent them. ( 18397297 )
2008
26
Is photosensitive epilepsy less common in males due to variation in X chromosome photopigment genes? ( 17521342 )
2007
27
Reasons to consider a plasma screen television--photosensitive epilepsy. ( 17922779 )
2007
28
Suppressive efficacy by a commercially available blue lens on PPR in 610 photosensitive epilepsy patients. ( 16529617 )
2006
29
Monozygous twin brothers discordant for photosensitive epilepsy: first report of possible visual priming in humans. ( 16146452 )
2005
30
Ocular defects in photosensitive epilepsy. ( 15105955 )
2004
31
Efficacy of sodium valproate in the treatment of photosensitive epilepsy (PSE) and the probable reasons for the persistence of occipital spikes. ( 15311327 )
2004
32
The reflex epilepsies with emphasis on photosensitive epilepsy. ( 16106643 )
2004
33
A novel nonpharmacologic treatment for photosensitive epilepsy: a report of three patients tested with blue cross-polarized glasses. ( 15329083 )
2004
34
Self induced photosensitive epilepsy. ( 15280616 )
2004
35
Paroxysmal eyelid movements: a confusing feature of generalized photosensitive epilepsy. ( 15249608 )
2004
36
Gamma-band phase clustering and photosensitivity: is there an underlying mechanism common to photosensitive epilepsy and visual perception? ( 12690055 )
2003
37
Photosensitive epilepsy beyond adolescence: is freedom from photosensitivity age-dependent? ( 12955814 )
2003
38
Near reflex accommodation spasm: unusual presentation of generalized photosensitive epilepsy. ( 12383431 )
2002
39
Refractory photosensitive epilepsy associated with a complex rearrangement of chromosome 2. ( 12571788 )
2002
40
PokAcmon contagion: photosensitive epilepsy or mass psychogenic illness? ( 11235034 )
2001
41
Cross polarized spectacles in photosensitive epilepsy. ( 11759770 )
2001
42
Lack of cortical contrast gain control in human photosensitive epilepsy. ( 10700258 )
2000
43
A case of comorbidity between panic disorder and photosensitive epilepsy. ( 10965285 )
2000
44
Brain activation during intermittent photic stimulation: a [15O]-water PET study on photosensitive epilepsy. ( 10487168 )
1999
45
Treatment of photosensitive epilepsy using coloured glasses. ( 10627405 )
1999
46
Clinical significance of EEG abnormalities during photic stimulation in patients with photosensitive epilepsy. ( 10080521 )
1999
47
Photosensitive epilepsy studied by functional magnetic resonance imaging and magnetic resonance spectroscopy. ( 10487166 )
1999
48
Televised material and photosensitive epilepsy. ( 10487176 )
1999
49
Evaluation of the laboratory and environmental factors that induce seizures in photosensitive epilepsy. ( 10427355 )
1999
50
Hemodynamic and metabolic aspects of photosensitive epilepsy revealed by functional magnetic resonance imaging and magnetic resonance spectroscopy. ( 10403215 )
1999

Variations for Photosensitive Epilepsy

Expression for Photosensitive Epilepsy

Search GEO for disease gene expression data for Photosensitive Epilepsy.

Pathways for Photosensitive Epilepsy

GO Terms for Photosensitive Epilepsy

Biological processes related to Photosensitive Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter transport GO:0006836 8.62 SLC6A18 SV2A

Sources for Photosensitive Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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