Aliases & Classifications for Phototoxic Dermatitis

MalaCards integrated aliases for Phototoxic Dermatitis:

Name: Phototoxic Dermatitis 12 15 17
Dermatitis, Phototoxic 44 70
Photosensitisation Reaction 12
Photosensitive Dermatitis 12
Photosensitiveness 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4407
MeSH 44 D017484
NCIt 50 C4816
SNOMED-CT 67 53597009
UMLS 70 C0162830

Summaries for Phototoxic Dermatitis

MalaCards based summary : Phototoxic Dermatitis, also known as dermatitis, phototoxic, is related to photoparoxysmal response 1 and dermatitis, and has symptoms including photophobia An important gene associated with Phototoxic Dermatitis is TRIM21 (Tripartite Motif Containing 21). The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia : 73 Photodermatitis, sometimes referred to as sun poisoning or photoallergy, is a form of allergic contact... more...

Related Diseases for Phototoxic Dermatitis

Graphical network of the top 20 diseases related to Phototoxic Dermatitis:



Diseases related to Phototoxic Dermatitis

Symptoms & Phenotypes for Phototoxic Dermatitis

UMLS symptoms related to Phototoxic Dermatitis:


photophobia

Drugs & Therapeutics for Phototoxic Dermatitis

Drugs for Phototoxic Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Racepinephrine Approved Phase 4 329-65-7 838
3
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
4
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
5
Ethanol Approved Phase 4 64-17-5 702
6
Fluorouracil Approved Phase 4 51-21-8 3385
7
Phenothiazine Experimental, Vet_approved Phase 4 92-84-2
8 Epinephryl borate Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Analgesics Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Antirheumatic Agents Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Anticonvulsants Phase 4
15 Antimetabolites Phase 4
16
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
17
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
18
Butenafine Approved Phase 3 101828-21-1 2484
19
Methylene blue Approved, Investigational Phase 3 61-73-4
20
Levetiracetam Approved Phase 2, Phase 3 102767-28-2 441341
21
Brivaracetam Approved, Investigational Phase 2, Phase 3 357336-20-0 9837243
22
Fenfluramine Approved, Illicit, Investigational, Withdrawn Phase 3 458-24-2 3337
23 Hematoporphyrins Phase 3
24 Antifungal Agents Phase 3
25 Pharmaceutical Solutions Phase 3
26 Serotonin Uptake Inhibitors Phase 3
27 Sunflower Phase 3
28 Photosensitizing Agents Phase 3
29
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
30
Norepinephrine Approved Phase 2 51-41-2 439260
31
Mepivacaine Approved, Vet_approved Phase 2 96-88-8 4062
32
Papain Approved Phase 2 9001-73-4
33
Aminolevulinic acid Approved Phase 1, Phase 2 106-60-5 137
34
Lorazepam Approved Phase 2 846-49-1 3958
35
Carbamazepine Approved, Investigational Phase 2 298-46-4 2554
36
Sirolimus Approved, Investigational Phase 2 53123-88-9 6436030 5284616
37
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
38
Fluoxymesterone Approved, Illicit Phase 1, Phase 2 76-43-7 6446
39
nivolumab Approved Phase 2 946414-94-4
40
Vemurafenib Approved Phase 2 918504-65-1 42611257 23252090
41
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
42
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
43
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 5280795 6221
44
Melatonin Approved, Nutraceutical, Vet_approved Phase 2 73-31-4 896
45 Methyl 5-aminolevulinate Phase 1, Phase 2
46 Dermatologic Agents Phase 1, Phase 2
47 Neurotransmitter Agents Phase 2
48 Psychotropic Drugs Phase 2
49 Gastrointestinal Agents Phase 2
50 Hypnotics and Sedatives Phase 2

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
2 Comparison of the Efficacy and Tolerability of Solaraze for 3 vs. 6 Months in Patients With Mild to Moderate Actinic Keratosis Located at the Face and Head Completed NCT00204542 Phase 4 Diclofenac;Diclofenac
3 Effect of Small Changes in Plasma Valproic Acid Concentration on the Photoparoxysmal Response Completed NCT00609245 Phase 4 Valproic Acid;Placebo
4 Photosensitivity of the Skin Under Azathioprin in Renal Transplant Recipients Completed NCT00492895 Phase 4 Discontinuation of Azathioprin
5 Treatment of AKs With Daylight-PDT: Comparing Two Photosensitizers (BF-200 ALA and MAL) Completed NCT01893203 Phase 4 BF-200 ALA cream;MAL cream
6 Daylight Mediated Photodynamic Therapy for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL) Completed NCT02464709 Phase 4 Aminolevulinic Acid;Methyl 5-aminolevulinate
7 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling in Patients With Advanced Chronic Periodontitis Completed NCT03498404 Phase 4
8 Conventional Microneedling Compared to Microneedling Associated With 5-FU Infusion (Microinfusion of Medication Into the Skin - MMP) for Idiopathic Guttate Hypomelanosis (IGH) Repigmentation Recruiting NCT02904564 Phase 4 MMP with 5-FU;MMP with Saline infusion
9 Two-arm Phase III Trial Comparing Different Time of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer Unknown status NCT02628665 Phase 3 photosensitizer(photofrin)
10 HT201308- Human Phototoxicity Test Completed NCT04531527 Phase 3 Butenafine HCl 1% (BAY1896425)
11 Efficacy and Safety of Metvix® Natural Daylight Photodynamic Therapy Versus Conventional Metvix® Photodynamic Therapy in Subject With Mild Actinic Keratoses Completed NCT02373371 Phase 3 Metvix®
12 Does BRV Have a Faster Onset Time and Greater Effect Than LEV in Epilepsy Patients?: A Prospective, Randomized, Crossover, Double-blind, Controlled Intravenous Study Using the PPR as a Pharmacodynamic Efficacy Endpoint Completed NCT03580707 Phase 2, Phase 3 BRV vs LEV in randomized double blinded, crossover fashion
13 Laser Therapy Associated With Photodynamic Therapy in the Treatment of Oral Mucositis Induced by Chemotherapy in Young Patients: Randomized Blind Clinical Trial Completed NCT02555501 Phase 3
14 An Open-Label Treatment of ZX008 (Fenfluramine Hydrochloride) in Pediatric and Adult Epilepsy Patients (Ages 4-25) With Sunflower Syndrome. Active, not recruiting NCT03790137 Phase 3 Fenfluramine Hydrochloride
15 Photodynamic Therapy for Palliation of Unresectable Cholangiocarcinoma A Multicenter, Open Label, Randomized, Controlled Phase III Trial Terminated NCT00907413 Phase 3
16 Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis: a Clinical and Microbiological Trial Unknown status NCT03346460 Phase 2
17 Photodynamic Therapy Using a Novel Photosensitizer in Locally Advanced Hilar Cholangiocarcinoma Unknown status NCT02725073 Phase 2
18 Antimicrobial Photodynamic Therapy Mediated by PapaMBlue® on Chronic Periodontal Disease - Randomized Blind Controlled Trial Unknown status NCT03855345 Phase 2
19 Antimicrobial Photodynamic Therapy Mediated by Papain Gel on Peri-implantitis Lesions: A Randomized Controlled Clinical Trial Unknown status NCT03753958 Phase 2
20 A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram Response in Patients With Photosensitive Epilepsy Completed NCT00579384 Phase 2 JNJ-26489112;Placebo
21 A Phase 2a, Multi-center, Single-blind, Within-subject, Placebo-controlled Study to Assess the Pharmacodynamics of ACT-709478 in Subjects With Photosensitive Epilepsy Completed NCT03239691 Phase 2 ACT-709478 for oral use;Placebo
22 A Multicenter, Single-blind, Within-subject, Placebo-controlled Proof of Concept Study to Assess the Effect of Single Oral Doses of BGG492 on the Photoparoxysmal EEG Response in Patients With Photosensitive Epilepsy Completed NCT00784212 Phase 2 BGG492;BGG492;Placebo
23 A Double Blind, Randomized, Cross- Over Study Examining Efficacy Of Pf-06372865 In A Photosensitivity Epilepsy Study Using Lorazepam As A Positive Control Completed NCT02564029 Phase 2 PF-06372865;Placebo;Lorazepam
24 Assessment of Marketed AEDs in the Human Photosensitivity Proof of Concept Trial Completed NCT00894010 Phase 2 carbamazepine 400mg;levetiracetam 1000mg
25 A Placebo-controlled, Single-blind, Multi-center Study to Explore the Photoparoxysmal Response in Photosensitive Epileptic Subjects After One Single Oral Dose of Brivaracetam in Capsules. Completed NCT00401648 Phase 2 Brivaracetam
26 A Phase II Study of Axitinib in Metastatic Non-clear Cell Renal Cell Carcinoma Patients Previously Treated With Temsirolimus Completed NCT01798446 Phase 2 Axitinib
27 Application Success of Photodynamic Therapy and Diode Laser During Endodontic Therapy of Young Permanent Teeth Completed NCT03074136 Phase 2 0.5% Sodium hypochlorite
28 Daylight-mediated Photodynamic Therapy of Actinic Keratoses: a Randomized, Double-blinded Pilot Study Comparing Topical 0.2% Hexylaminolaevulinate With 16% Methylaminolaevulinate Completed NCT02149342 Phase 1, Phase 2 Hexylaminolaevulinate cream;Methylaminolaevulinate cream
29 Clinical Effects of a Single Application of a Novel Photosensitizer in The Treatment of Chronic Periodontitis - A Randomized Controlled Trial Recruiting NCT04374383 Phase 2 Phthalocyanine Dye;LASER assisted SRP
30 Superficial Basal Cell Cancer's Photodynamic Therapy: Comparing Three Photosensitizers: Hexylaminolevulinate and Aminolevulinic Acid Nano Emulsion Versus Methylaminolevulinate Active, not recruiting NCT02367547 Phase 1, Phase 2 Hexylaminolevulinate cream;Aminolevulinic Acid Nano Emulsion;Methylaminolevulinate cream
31 Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses Active, not recruiting NCT04140292 Phase 2 Photodynamic therapy (PDT);Vitamin D3
32 Intrapleural Photodynamic Therapy by Video-Assisted Thoracoscopy Followed by Anti-PD-1 NIVOLUMAB in Patients With Malignant Pleural Mesothelioma - a Pilot Study Not yet recruiting NCT04400539 Phase 2 Nivolumab Injection
33 Effectiveness of Antimicrobial Photodynamic Therapy and Guedes-Pinto Paste for Endodontic Treatment of Deciduous Teeth - Study Protocol for a Randomized Controlled Clinical Trial Not yet recruiting NCT04587089 Phase 1, Phase 2
34 Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation Not yet recruiting NCT04547439 Phase 2 Melatonin
35 A Multicenter, Double-Blind, Randomized, Cross-Over Study Evaluating Pharmacodynamic Activity of E2730 in Adult Subjects With Photosensitive Epilepsy Terminated NCT03603639 Phase 2 Placebo;E2730
36 A Multicenter, Double-Blind, Randomized, Crossover, Single-Dose Study With An Open-Label Treatment Period Evaluating Pharmacodynamic Activity of E2082 in Adult Subjects With Photosensitive Epilepsy Terminated NCT03686033 Phase 2 Placebo;E2082
37 Evaluation of Photosensitivity in Dabrafenib or Vemurafenib Treated Metastatic Melanoma Patients - a Phase IIa/IIb Study Terminated NCT02052193 Phase 2 Dabrafenib;Vemurafenib
38 Prospective, Randomized, Controlled, Partially Blinded, Skin Photobiological Clinical Study of the Efficacy and Safety of a Sunscreen Product as Skin Protector Against Porfimer Sodium-induced Phototoxicity to Visible Light Withdrawn NCT01256203 Phase 2 Solar Protection Formula SPF® 60
39 A Pilot Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity Completed NCT00353158 Phase 1 Doxycycline;Voriconazole
40 A 4-Day, Randomized Study to Evaluate the Potential of MC2-01 Cream to Induce a Phototoxicity Skin Reaction in Healthy Subjects, Using a Controlled Photopatch Test Design Completed NCT03892564 Phase 1 MC2-01 Cream, irradiation;MC2-01 Cream, no irradiation;MC2-01 vehicle, irradiation;MC2-01 vehicle, no irradiation;Control, irradiation
41 A Phase 1 Study Evaluating Skin Irritation, Phototoxicity and Safety After Administration of LEO 90105 on Intact Skin of Healthy Japanese Male Subjects A Single Centre, Randomised, Controlled, Investigator Blinded Study With Intra-individual Comparison of the Active Formulation and Its Components Completed NCT01293357 Phase 1 LEO 90105
42 A 4-Day, Randomized, Controlled Study to Evaluate the Phototoxicity Potential of FMX-101, 4% in Healthy Volunteers Completed NCT04070742 Phase 1 FMX101
43 Photosensitivity Trial. A Randomized, Double-blind, Double Dummy, Placebo- and Positive Controlled Phase I Trial to Evaluate the Photosensitizing Potential of TMC435 in Healthy Subjects. Completed NCT01124799 Phase 1 TMC435;Placebo;Ciprofloxacin
44 A Within-subject, Randomized, Evaluator-blinded, Vehicle-controlled Study to Assess the Photosensitization Potential of Finasteride Cutaneous Solution(P-3074) in Human Subjects Completed NCT02791243 Phase 1 Finasteride 0.25%;Placebo for Finasteride 0.25%;Negative Control
45 Partially-blind, Randomized, Parallel Group, Placebo and Active Comparator-controlled Phase I Clinical Trial to Evaluate the Photosensitivity Potential of BI 730357 Completed NCT04147260 Phase 1 BI 730357;Placebo to match BI 730357;Ciprofloxacin
46 A Phase 1 Trial of Photodynamic Therapy With HPPH in Patients With Pleural Malignancy Completed NCT01673074 Phase 1 (PDT) Photodynamic therapy
47 Tolerability and Efficacy of Daylight Aminolevulinic-acid-photodynamic Therapy (ALA-PDT) Compared With Conventional ALA-PDT for Treatment of Actinic Keratosis on the Face or Scalp Completed NCT03322293 Phase 1 Aminolevulinic Acid Topical 20% Topical Solution
48 Photodynamic Therapy (PDT) for Poor Prognosis Recurrent/Refractory Malignant Brain Tumors - A Phase I Study Completed NCT01682746 Phase 1 Photofrin (porfimer sodium) & photodynamic therapy.
49 A 6-Week, Randomized Study to Evaluate the Potential of CCP-020 (Diacerein 1%) Topical Ointment to Induce a Photoallergic Skin Reaction in Healthy Subjects, Using a Controlled Photopatch Test Design Completed NCT03473197 Phase 1 Diacerein 1% ointment
50 Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma in Basal Cell Nevus Syndrome Recruiting NCT03467789 Phase 1 Vitamin D3 pre-treatment;Maintenance Vitamin D3

Search NIH Clinical Center for Phototoxic Dermatitis

Cochrane evidence based reviews: dermatitis, phototoxic

Genetic Tests for Phototoxic Dermatitis

Anatomical Context for Phototoxic Dermatitis

MalaCards organs/tissues related to Phototoxic Dermatitis:

40
Skin

Publications for Phototoxic Dermatitis

Articles related to Phototoxic Dermatitis:

(show all 43)
# Title Authors PMID Year
1
Comparison of racial distribution of photodermatoses in USA academic dermatology clinics: A multicenter retrospective analysis of 1080 patients over a 10-year period. 61
32104953 2020
2
Lime-induced phytophotodermatitis. 61
31844529 2019
3
Sparfloxacin-induced photo-onycholysis and photosensitivity characteristically sparing lepromatous skin lesions: an interesting observation. 61
30244266 2018
4
[Methotrexate-associated photosensitization]. 61
25578302 2015
5
Finger and toenail onycholysis. 61
25512134 2015
6
Images in clinical medicine. Phototoxic dermatitis. 61
25099580 2014
7
Phytodermatitis in eastern Turkey: a retrospective, observational study. 61
24776729 2014
8
Nine case series with phototoxic dermatitis related to Chenopodium album. 61
22241627 2012
9
Bioactive compounds from natural resources against skin aging. 61
22115797 2011
10
Phototoxic dermatitis due to Chenopodium album in a child. 61
21854411 2011
11
Melan-a-positive "pseudomelanocytic nests": a pitfall in the histopathologic and immunohistochemical diagnosis of pigmented lesions on sun-damaged skin. 61
19384076 2009
12
Phytophotodermatitis in Rijeka region, Croatia. 61
19138025 2008
13
In vitro phototoxic potential and photochemical properties of imidazopyridine derivative: a novel 5-HT4 partial agonist. 61
18271033 2008
14
Contact reactions to food. 61
18589839 2008
15
In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study. 61
18207709 2008
16
[Purely natural: phototoxic dermatitis]. 61
17619401 2007
17
[Histopathology of photodermatoses]. 61
17093995 2006
18
[Toxic phytodermatitis caused by Euphorbia helioscopia L. (sun spurge)]. 61
15662536 2005
19
Phototoxic dermatitis due to Chenopodium album in a mother and son. 61
15982237 2005
20
Dacarbazine but not temozolomide induces phototoxic dermatitis in patients with malignant melanoma. 61
15097966 2004
21
Contact allergy to food. 61
15327475 2004
22
Berloque dermatitis induced by "Florida water". 61
12184670 2002
23
[Plant-induced toxic and allergic dermatitis (phytodermatitis)]. 61
11963200 2002
24
Melanocyte melanin augments sparfloxacin-induced phototoxicity. 61
10468189 1999
25
[Toxic contact dermatitis]. 61
1589676 1992
26
Tetracyclines, chloramphenicol, erythromycin, clindamycin, and metronidazole. 61
1749296 1991
27
[Phototoxic dermatitis following the use of Ammi majus fruit for vitiligo]. 61
2023655 1991
28
[Review of the literature on adverse reactions to sunscreens 1947 to 1989]. 61
2150456 1990
29
[The effect of metabolites of the epidermal barrier on the development of phototoxic dermatitis]. 61
2633545 1989
30
An outbreak of phototoxic dermatitis due to limes. 61
3812457 1987
31
Outbreak of phototoxic dermatitis from limes--Maryland. 61
3925324 1985
32
Textile dye dermatitis. A review. 61
4008703 1985
33
Phototoxic dermatitis from Sclerotinia sclerotiorum infected celery. 61
6540157 1984
34
Recall of UVB-induced erythema in breast cancer patient receiving multiple drug chemotherapy. 61
6527953 1984
35
Phototoxic dermatitis caused by celery infected by Sclerotinia sclerotiorum. 61
6228376 1983
36
Tetracyclines, chloramphenicol, erythromycin, and clindamycin. 61
6823163 1983
37
[Phototoxic dermatitis caused by DTIC-treatment]. 61
7405333 1980
38
Phototoxic polyacetylenes and their thiophene derivatives. (Effects on human skin). 61
378524 1979
39
[Phototoxic reactions to 8-methoxypsoralen as occupational dermatosis]. 61
154483 1979
40
Inhibition of ultraviolet and phototoxic dermatitis in the mouse. 61
82323 1978
41
Tetracyclines, chloramphenicol, erythromycin, and clindamycin. 61
909315 1977
42
Phototoxic textile dermatitis ("bikini dermatitis"). 61
962342 1976
43
Phototoxic dermatitis in a horse. (A case report). 61
5198169 1970

Variations for Phototoxic Dermatitis

Expression for Phototoxic Dermatitis

Search GEO for disease gene expression data for Phototoxic Dermatitis.

Pathways for Phototoxic Dermatitis

GO Terms for Phototoxic Dermatitis

Biological processes related to Phototoxic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of NF-kappaB transcription factor activity GO:0032088 8.62 TRIM21 IRAK1

Molecular functions related to Phototoxic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.8 SRD5A2 PPOX LDHC

Sources for Phototoxic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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