Aliases & Classifications for Physical Disorder

MalaCards integrated aliases for Physical Disorder:

Name: Physical Disorder 12 15
Physical Illness 73


External Ids:

Disease Ontology 12 DOID:0080015
UMLS 73 C0683323

Summaries for Physical Disorder

Disease Ontology : 12 A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

MalaCards based summary : Physical Disorder, also known as physical illness, is related to syngnathia and agnathia-otocephaly complex, and has symptoms including illness (finding) An important gene associated with Physical Disorder is RNU4ATAC (RNA, U4atac Small Nuclear (U12-Dependent Splicing)), and among its related pathways/superpathways are Neuroscience and Cytoskeletal Signaling. The drugs Dopamine and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are growth/size/body region and cellular

Wikipedia : 76 A physical disorder (as a medical term) is often used as a term in contrast to a mental disorder, in an... more...

Related Diseases for Physical Disorder

Diseases related to Physical Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 syngnathia 31.3 IRF6 MSX1 SATB2
2 agnathia-otocephaly complex 31.2 DCX MSX1 NODAL SHH
3 orofacial cleft 30.9 IRF6 MSX1 NHLH1 NODAL RPS17 SATB2
4 visceral heterotaxy 10.6
5 fetal alcohol spectrum disorder 10.6
6 renal-hepatic-pancreatic dysplasia 10.6
7 omphalocele 10.6
8 bladder exstrophy-epispadias-cloacal exstrophy complex 10.6
9 klippel-feil syndrome 10.6
10 hypospadias 10.6
11 patulous eustachian tube 10.6
12 chromosome 17p13.3, centromeric, duplication syndrome 10.4 DCX PAFAH1B1
13 acquired schizencephaly 10.3 SHH SIX3
14 maxillonasal dysplasia, binder type 10.3 SATB2 SHH
15 cleft lip and alveolus 10.3 IRF6 MSX1
16 tooth size 10.3 MSX1 SHH
17 patau syndrome 10.3 NODAL SIX3 ZIC2
18 bone development disease 10.3 PIK3R2 RNU4ATAC SHOX2
19 microcephaly 5, primary, autosomal recessive 10.3 CEP63 MCPH1 SATB2
20 septopreoptic holoprosencephaly 10.3 NODAL SHH SIX3 ZIC2
21 holoprosencephaly 10.3 NODAL SHH SIX3 ZIC2
22 hard palate cancer 10.3 MSX1 SHOX2 TMEM54
23 midline interhemispheric variant of holoprosencephaly 10.3 NODAL SHH SIX3 ZIC2
24 alobar holoprosencephaly 10.3 NODAL SHH SIX3 ZIC2
25 lissencephaly, x-linked, 1 10.3 DCX PAFAH1B1
26 lobar holoprosencephaly 10.3 NODAL SHH SIX3 ZIC2
27 microform holoprosencephaly 10.3 NODAL SHH SIX3 ZIC2
28 chromosome 18p deletion syndrome 10.3 NODAL SHH SIX3 ZIC2
29 neuronal migration disorders 10.3 DCX FLNA PAFAH1B1
30 semilobar holoprosencephaly 10.2 NODAL SHH SIX3 ZIC2
31 microcephaly 7, primary, autosomal recessive 10.2 CEP63 MCPH1 NODAL SHH
32 respiratory system disease 10.2 PIK3R2 SHOX2 TUBB3
33 isolated cleft lip 10.2 IRF6 MSX1
34 seckel syndrome 10.2 CEP63 MCPH1 RNU4ATAC
35 periventricular nodular heterotopia 10.2 DCX FLNA PAFAH1B1 SIX3
36 band heterotopia 10.2 DCX FLNA PAFAH1B1 SIX3 TUBB3
37 holoprosencephaly 4 10.2 SHH ZIC2
38 tooth agenesis 10.2 IRF6 MSX1 SATB2 TMEM54
39 west syndrome 10.2 FLNA PAFAH1B1 SHOX2
40 lissencephaly with cerebellar hypoplasia 10.2 DCX PAFAH1B1
41 microcephaly 3, primary, autosomal recessive 10.1 CEP63 MCPH1
42 cleft palate, isolated 10.1 FLNA IRF6 MSX1 NHLH1 SATB2 SHOX2
43 congenital nervous system abnormality 9.9 CEP63 DCX FLNA MCPH1 NODAL PAFAH1B1
44 tobacco addiction 9.5
45 anxiety 9.5
46 smoking as a quantitative trait locus 3 9.5
47 alacrima, achalasia, and mental retardation syndrome 9.5
48 chronic mountain sickness 9.5
49 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.5
50 alexithymia 9.5

Graphical network of the top 20 diseases related to Physical Disorder:

Diseases related to Physical Disorder

Symptoms & Phenotypes for Physical Disorder

UMLS symptoms related to Physical Disorder:

illness (finding)

MGI Mouse Phenotypes related to Physical Disorder:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 CEP63 DCX FLNA IRF6 MCPH1 MSX1
2 cellular MP:0005384 10.24 CEP63 FLNA INSL3 IRF6 MCPH1 NODAL
3 behavior/neurological MP:0005386 10.22 CEP63 DCX FLNA INSL3 MCPH1 MSX1
4 cardiovascular system MP:0005385 10.21 FLNA MCPH1 MSX1 NHLH1 NODAL PIK3R2
5 mortality/aging MP:0010768 10.17 DCX FLNA IRF6 MCPH1 MSX1 NHLH1
6 craniofacial MP:0005382 10.13 FLNA IRF6 MSX1 NODAL SATB2 SHH
7 digestive/alimentary MP:0005381 10.11 FLNA IRF6 MSX1 NODAL SATB2 SHH
8 nervous system MP:0003631 10.1 CEP63 DCX FLNA MCPH1 MSX1 NHLH1
9 embryo MP:0005380 10.03 IRF6 MSX1 NODAL PAFAH1B1 SATB2 SHH
10 limbs/digits/tail MP:0005371 9.85 IRF6 MSX1 SATB2 SHH SHOX2 ZIC2
11 reproductive system MP:0005389 9.76 CEP63 DCX FLNA INSL3 MCPH1 NODAL
12 respiratory system MP:0005388 9.5 FLNA MSX1 NODAL SATB2 SHH SIX3
13 skeleton MP:0005390 9.36 FLNA INSL3 IRF6 MCPH1 MSX1 NODAL

Drugs & Therapeutics for Physical Disorder

Drugs for Physical Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
Lithium carbonate Approved Phase 4 554-13-2
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
6 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
7 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Not Applicable
8 Dopamine Antagonists Phase 4,Not Applicable
9 Antipsychotic Agents Phase 4,Not Applicable
10 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
13 Antidepressive Agents Phase 4,Phase 2,Not Applicable
14 Autonomic Agents Phase 4,Phase 2,Not Applicable
15 Dopamine Agents Phase 4,Not Applicable
16 Antidepressive Agents, Second-Generation Phase 4,Phase 2,Not Applicable
17 Serotonin Uptake Inhibitors Phase 4,Phase 2,Not Applicable
18 Serotonin Agents Phase 4,Phase 2,Not Applicable
19 Antimanic Agents Phase 4
20 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Not Applicable
21 Gastrointestinal Agents Phase 4
22 Antiemetics Phase 4
23 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
24 Cytochrome P-450 Enzyme Inhibitors Phase 4
25 Dopamine Uptake Inhibitors Phase 4
26 Dopamine agonists Phase 4
Serotonin Investigational, Nutraceutical Phase 4,Phase 2,Not Applicable 50-67-9 5202
28 tannic acid Approved Phase 3,Not Applicable
Benzocaine Approved, Investigational Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
Eszopiclone Approved, Investigational Phase 3,Phase 1 138729-47-2 969472
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
32 Hypnotics and Sedatives Phase 3,Phase 1
33 Calcium, Dietary Phase 3
34 Anti-Anxiety Agents Phase 3
35 Anticonvulsants Phase 3
36 calcium channel blockers Phase 3
37 Analgesics Phase 3,Not Applicable
Citalopram Approved Phase 2,Not Applicable 59729-33-8 2771
Moclobemide Approved, Investigational Phase 2 71320-77-9 4235
40 Parasympatholytics Phase 2,Not Applicable
41 Cholinergic Antagonists Phase 2,Not Applicable
42 Antiparkinson Agents Phase 2,Not Applicable
43 Cholinergic Agents Phase 2,Not Applicable
44 Muscarinic Antagonists Phase 2,Not Applicable
45 Monoamine Oxidase Inhibitors Phase 2
Sulpiride Approved, Investigational Not Applicable 15676-16-1 5355
Ethanol Approved Not Applicable 64-17-5 702
Nicotine Approved Not Applicable 54-11-5 942 89594
49 Cariostatic Agents Not Applicable
50 Sympathomimetics Not Applicable

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features Completed NCT00202293 Phase 4 Olanzapine;Lithium;Chlorpromazine
2 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease Completed NCT02162862 Phase 4 bupropion-SR
3 CHANGE -it is About Life Completed NCT01585493 Phase 3
4 A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150) Completed NCT00770692 Phase 3 Eszopiclone 1 mg- Elderly;Eszopiclone 2 mg- Elderly;Eszopiclone 3 mg- Non-elderly;Eszopiclone 2 mg- Non-elderly
5 Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia Completed NCT01270828 Phase 3 Pregabalin;placebo
6 Detection and Treatment of Depression in Patients Admitted to the General Hospital Unknown status NCT00521911 Phase 2
7 Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer Terminated NCT03010761 Phase 2 escitalopram;Moclobemide;Placebo - Cap
8 Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) for Thyroid Cancer Patients Withdrawn NCT01994200 Phase 1, Phase 2
9 A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102) Completed NCT01055834 Phase 1 Eszopiclone 3 mg;Eszopiclone 1 mg
10 Sinovuyo Caring Families Project - Pilot Trial Completed NCT01802294 Phase 1
11 Effect of Combined Exercise Post-treatment Intervention in Lean Mass Recovery in Breast Cancer Survival. Unknown status NCT01843608 Not Applicable
12 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
13 Mind Body Therapy During Geriatric Rehabilitation Unknown status NCT01074788 Not Applicable
14 [18 Fluorine(F)]DOPA Determinants and Predictors of Treatment Response in Psychosis Unknown status NCT02880995 Not Applicable 6 weeks of treatment with amisulpride
15 Internet-Based Interventions for Bipolar Disorder Unknown status NCT02106078 Not Applicable
16 Treatment of Depressed Adolescents With Physical Illness Completed NCT00446238 Not Applicable
17 Effectiveness of a Self-care Intervention for Depression in Primary Care Patients With Chronic Physical Illnesses Completed NCT01521013 Not Applicable
18 Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness Completed NCT00769353 Not Applicable
19 Depression, Genes, Cytokines, Chronic Fatigue, Physical Illnesses and Quality of Life Completed NCT02943330
20 Efficacy of Neuromuscular Electrical Stimulation in Geriatric Population Completed NCT03409575 Not Applicable
21 Study Of Telemedicine Consultation at Home For Older Adults Completed NCT01324687
22 Laser Therapy, Pain and Carpometacarpal Joint Osteoarthritis Treatment Completed NCT03270488 Not Applicable
23 Influence of Multi-dimensional Wellness Program on Quality of Life Completed NCT01927250 Not Applicable
24 Safety/Effectiveness Study of a Single Session of Laying-on-of-hands in Various Settings in Japan Completed NCT01316029
25 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
26 Randomized Controlled Trial of Mind-Body Breathing Therapy (in Chronic Obstructive Pulmonary Disease) To Improve Palliation of Dyspnea and Health-Related Quality of Life Completed NCT00243282 Not Applicable
27 Auriculotherapy on Lower Urinary Tract Symptoms in Elderly Men Completed NCT02330107 Not Applicable
28 Study of Arsha Vidya Chhatralaya Initiative on Health and Functioning of Disadvantaged Tribal Children Completed NCT03578159
29 Role of Rehabilitation for the Repair of Pelvic Floor Injuries Associated to Vaginal Delivery Identified by 3/4D Transperineal Ultrasound Completed NCT03592160 Not Applicable
30 Life Quality and Health in Patients With Klinefelter Syndrome Completed NCT01690013
31 Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour Completed NCT02615405 Not Applicable
32 Evaluation of a Gamified Electronic Medication Administration Record (eMAR) System Completed NCT03219151 Not Applicable
33 Improving Health and Reducing Disability of Depressed Elderly With Chronic Conditions Through Qigong Exercise Completed NCT03591198 Not Applicable
34 Stress Management Program for World Trade Center (WTC) Responders Completed NCT02457780 Not Applicable
35 Get Moving and Get Well - Pilot Study Completed NCT01884025 Not Applicable
36 The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study Completed NCT02421146 Not Applicable
37 Evaluation of Telehealth Interventions for Post-Trauma Stress Completed NCT00350584 Not Applicable
38 MAPS Group Therapy Model for Bipolar Disorder Completed NCT01152034 Not Applicable
39 The Effect of Patient and Investigator Expectation on the Efficacy of Escitalopram in the Treatment Depression Completed NCT02480400 Not Applicable Escitalopram;Escitalopram
40 Impact of Video Presentations on Medical Students' Attitudes Toward Mental Illness Completed NCT03231761 Not Applicable
41 Analgesic Current Therapies for Chronic Neck Pain Completed NCT03121859 Not Applicable
42 Reducing Stigma Among Healthcare Providers to Improve Mental Health Services Completed NCT02793271 Not Applicable
43 Internet-Based Interventions for Bipolar Disorder (MoodSwings 2) Completed NCT02118623 Not Applicable
44 Effectiveness Rehabilitation Hematopoietic Transplantation (ovERsHOT) Completed NCT03324620 Not Applicable
45 Repair by Rehabilitation of Pelvic Floor Lesions After Vaginal Delivery Identified by Transperineal Ultrasound 3/4 D Recruiting NCT03686956 Not Applicable
46 Communitas: A Program for Teens Living With Chronic Illness and Their Families Recruiting NCT03170167
47 Narrative Exposure Therapy in Patients With Psychotic Disorders and a Posttraumatic Stress Disorder Recruiting NCT03730831 Not Applicable
48 Peer Navigators to Address Obesity-Related Concerns for African Americans With Serious Mental Illness Recruiting NCT03382782 Not Applicable
49 Enhanced Stress Resilience Training for Faculty Recruiting NCT03516877 Not Applicable
50 Heart Failure Insomnia Treatment Study Recruiting NCT03636880 Not Applicable

Search NIH Clinical Center for Physical Disorder

Genetic Tests for Physical Disorder

Anatomical Context for Physical Disorder

MalaCards organs/tissues related to Physical Disorder:

Brain, Testes, Eye, Spinal Cord, Heart, Cortex

Publications for Physical Disorder

Articles related to Physical Disorder:

(show top 50) (show all 467)
# Title Authors Year
The role of neighborhoods in household food insufficiency: Considering interactions between physical disorder, low social capital, violence, and perceptions of danger. ( 30557777 )
Effectiveness of mindfulness-based arts interventions on psychological wellbeing and fatigue in adults with a physical illness: a systematic review protocol. ( 29995707 )
Learning About the Management of Physical Illness During the Postgraduate Training to Become a Good Psychiatrist. ( 28875286 )
A cross-continental analysis of weight gain, psychiatric diagnoses and medication use during inpatient psychiatric treatment. The international study on physical illness in mentally ill. ( 29331602 )
Comorbidity of mental illness and chronic physical illness: A diagnostic and treatment conundrum. ( 29993137 )
Inequitable Physical Illness and Premature Mortality for People with Severe Mental Illness in Australia: A Social Analysis. ( 30008569 )
Lifetime Spousal Violence Victimization and Perpetration, Physical Illness, and Health Risk Behaviours among Women in India. ( 30518101 )
Mooney et al. Respond to "Observing Neighborhood Physical Disorder". ( 28899030 )
Invited Commentary: Observing Neighborhood Physical Disorder in an Age of Technological Innovation. ( 28899029 )
Chronic Physical Illness Burden and Suicidal Ideation Among Dominicans in New York City. ( 27507022 )
Systematic Review: Bullying Involvement of Children With and Without Chronic Physical Illness and/or Physical/Sensory Disability-a Meta-Analytic Comparison With Healthy/Nondisabled Peers. ( 27784727 )
Stigma of mental and physical illness and the use of mobile technology. ( 27841705 )
Physical illness in those with mental illness: psychiatric services need to change focus. ( 28052889 )
Ageing and mental health: changes in self-reported health due to physical illness and mental health status with consecutive cross-sectional analyses. ( 28100564 )
Gene-environment interplay in depressive symptoms: moderation by age, sex, and physical illness. ( 28202098 )
Exploring the effectiveness of couples interventions for adults living with a chronic physical illness: A systematic review. ( 28228340 )
Research Review: Childhood chronic physical illness and adult emotional health - a systematic review and meta-analysis. ( 28449285 )
Understanding the Progression from Physical Illness to Suicidal Behavior: A Case Study Based on a Newly Developed Conceptual Model. ( 28452674 )
Do US Medical Licensing Applications Treat Mental and Physical Illness Equivalently? ( 28633174 )
A systematic review and meta-analysis of written self-administered psychosocial interventions among adults with a physical illness. ( 28734559 )
Contributing to making the school a safe place for the child: School nurses' perceptions of their assignment when caring for children having parents with serious physical illness. ( 29085652 )
Social Origins of Developmental Risk for Mental and Physical Illness. ( 29118206 )
Attitudes towards assisted suicide and euthanasia among care-dependent older adults (50+) in Austria: the role of socio-demographics, religiosity, physical illness, psychological distress, and social isolation. ( 29212490 )
The association of physical illness and self-harm resulting in hospitalisation among older people in a population-based study. ( 26471731 )
The role of neighborhood disadvantage, physical disorder, and collective efficacy in adolescent alcohol use: a multilevel path analysis. ( 27521816 )
Neighborhood Physical Disorder and Psychological Distress: Does the Risk Increase With Age? ( 27913760 )
Neighborhood Physical Disorder in New York City. ( 27482283 )
Chronic physical illness in early life and risk of chronic widespread and regional pain at age 68: evidence from the 1946 British birth cohort. ( 27547897 )
Psychogenic Explanations of Physical Illness: Time to Examine the Evidence. ( 27694458 )
Examining the relationship between physical illness and depression: Is there a difference between inflammatory and non inflammatory diseases? A cohort study. ( 27796262 )
Physical Illness in Gay, Lesbian, and Heterosexual Marriages: Gendered Dyadic Experiences. ( 27799592 )
On listening to the dreams of children affected by a serious physical illness. ( 26222810 )
A systematic review of physical illness, functional disability, and suicidal behaviour among older adults. ( 26381843 )
Assessing the role of physical illness in young old and older old suicide attempters. ( 26560405 )
Perceived barriers to and facilitators of labor market engagement for individuals with chronic physical illness in their experience with disability policy: a systematic review of qualitative evidence protocol. ( 26767816 )
Strategies to deal with comorbid physical illness in psychosis. ( 26888363 )
Depression predicts future emergency hospital admissions in primary care patients with chronic physical illness. ( 26919799 )
The impact of chronic physical illness, maternal depressive symptoms, family functioning, and self-esteem on symptoms of anxiety and depression in children. ( 24938212 )
Days out of role due to mental and physical illness in the South African stress and health study. ( 25096982 )
Older men and older women remand prisoners: mental illness, physical illness, offending patterns and needs. ( 25428523 )
Improving the diagnosis of physical illness in patients with mental illness who present in emergency departments: consensus study. ( 25637525 )
In sickness and in health? Physical illness as a risk factor for marital dissolution in later life. ( 25722125 )
Prevention and treatment of psychiatric disorders in children with chronic physical illness. ( 25784735 )
Psychological interventions for mental health disorders in children with chronic physical illness: a systematic review. ( 25784736 )
Communication with patients suffering from serious physical illness. ( 25832510 )
Association between trajectories of maternal depression and subsequent psychological functioning in youth with and without chronic physical illness. ( 25844906 )
Tumour necrosis factor-α inhibitor therapy in chronic physical illness: A systematic review and meta-analysis of the effect on depression and anxiety. ( 25935351 )
Understanding depression associated with chronic physical illness: a Q-methodology study in primary care. ( 26009535 )
In Sickness and in Health? Physical Illness as a Risk Factor for Marital Dissolution in Later Life. ( 26315504 )
Neighborhood physical disorder, social cohesion, and insomnia: results from participants over age 50 in the Health and Retirement Study. ( 25222023 )

Variations for Physical Disorder

Expression for Physical Disorder

Search GEO for disease gene expression data for Physical Disorder.

Pathways for Physical Disorder

Pathways related to Physical Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
4 9.91 NODAL SHH

GO Terms for Physical Disorder

Biological processes related to Physical Disorder according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.97 DCX NODAL PAFAH1B1 SHOX2 ZIC2
2 transcription by RNA polymerase II GO:0006366 9.93 IRF6 MSX1 NHLH1 SATB2 SIX3 ZIC2
3 heart development GO:0007507 9.86 MSX1 NODAL SHH SHOX2
4 central nervous system development GO:0007417 9.8 DCX NHLH1 SHH
5 neuron migration GO:0001764 9.78 DCX PAFAH1B1 SATB2
6 anterior/posterior pattern specification GO:0009952 9.77 MSX1 NODAL SHH
7 cerebral cortex development GO:0021987 9.72 FLNA MCPH1 PAFAH1B1
8 roof of mouth development GO:0060021 9.71 MSX1 SATB2 SHH
9 cell development GO:0048468 9.7 IRF6 NODAL SHH
10 embryonic limb morphogenesis GO:0030326 9.67 MSX1 SHH SHOX2
11 brain development GO:0007420 9.65 DCX NODAL PAFAH1B1 SIX3 ZIC2
12 anatomical structure formation involved in morphogenesis GO:0048646 9.64 NODAL SHH
13 establishment of mitotic spindle orientation GO:0000132 9.63 MCPH1 PAFAH1B1
14 neuroblast proliferation GO:0007405 9.62 PAFAH1B1 SHH
15 osteoblast development GO:0002076 9.62 SATB2 SHH
16 embryonic digestive tract morphogenesis GO:0048557 9.61 SHH SHOX2
17 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 IRF6 MSX1 NHLH1 NODAL PIK3R2 SATB2
18 embryonic morphogenesis GO:0048598 9.59 SHH SHOX2
19 digestive tract morphogenesis GO:0048546 9.58 NODAL SHH
20 layer formation in cerebral cortex GO:0021819 9.58 DCX PAFAH1B1
21 embryonic forelimb morphogenesis GO:0035115 9.54 MSX1 SHH SHOX2
22 telencephalon regionalization GO:0021978 9.51 SHH SIX3
23 positive regulation of protein import into nucleus GO:0042307 9.5 FLNA PIK3R2 SHH
24 mesenchymal cell proliferation GO:0010463 9.48 MSX1 SHH
25 formation of anatomical boundary GO:0048859 9.43 NODAL SHH
26 regulation of odontogenesis GO:0042481 9.4 MSX1 SHH
27 embryonic pattern specification GO:0009880 9.33 NODAL SATB2 SHH
28 multicellular organism development GO:0007275 9.32 DCX MSX1 NHLH1 NODAL PAFAH1B1 SATB2

Molecular functions related to Physical Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.7 IRF6 MSX1 NHLH1 SATB2 SHOX2 SIX3
2 sequence-specific DNA binding GO:0043565 9.65 IRF6 MSX1 SATB2 SHOX2 SIX3
3 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.26 MSX1 NHLH1 SATB2 ZIC2
4 morphogen activity GO:0016015 8.62 NODAL SHH

Sources for Physical Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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