Aliases & Classifications for Physical Disorder

MalaCards integrated aliases for Physical Disorder:

Name: Physical Disorder 12 15
Physical Illness 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0080015
UMLS 70 C0683323

Summaries for Physical Disorder

Disease Ontology : 12 A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

MalaCards based summary : Physical Disorder, also known as physical illness, is related to fetal alcohol spectrum disorder and syngnathia, and has symptoms including illness (finding) An important gene associated with Physical Disorder is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor), and among its related pathways/superpathways are Dopaminergic Neurogenesis and Tgif disruption of Shh signaling. The drugs Ibuprofen and interferons have been mentioned in the context of this disorder. Affiliated tissues include breast, eye and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 A physical disorder (as a medical term) is often used as a term in contrast to a mental disorder, in an... more...

Related Diseases for Physical Disorder

Diseases related to Physical Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 32.0 SHH MIR9-1 MIR140 H2AC18
2 syngnathia 32.0 MSX1 IRF6 FGF8
3 orofacial cleft 31.9 ZIC2 SHH PRODH MTHFR MSX1 MIR140
4 meckel diverticulum 10.7
5 silver-russell syndrome 1 10.7
6 agnathia-otocephaly complex 10.7
7 cardiac valvular defect, developmental 10.7
8 sacral defect with anterior meningocele 10.7
9 polydactyly 10.7
10 visceral heterotaxy 10.7
11 renal-hepatic-pancreatic dysplasia 10.7
12 omphalocele 10.7
13 bladder exstrophy-epispadias-cloacal exstrophy complex 10.7
14 klippel-feil syndrome 10.7
15 hypospadias 10.7
16 patulous eustachian tube 10.7
17 tooth size 10.6 SHH MSX1 FGF8
18 eye degenerative disease 10.6 RNU4ATAC PRODH H2AC18 ERCC6 EPRS1
19 x-linked monogenic disease 10.6 PRODH MIR9-1 H2AC18 ERCC6 EPRS1
20 hypomyelinating leukodystrophy 10.6 PRODH H2AC18 ERCC6 EPRS1
21 cerebellar disease 10.6 RNU4ATAC PRODH PAFAH1B1 MIR9-1 H2AC18 ERCC6
22 muscle tissue disease 10.6 RNU4ATAC MIR9-1 H2AC18 ERCC6 EPRS1 B3GNT2
23 amino acid metabolic disorder 10.6 PRODH MTHFR H2AC18 EPRS1
24 pervasive developmental disorder 10.6 PRODH MIR9-1 MIR140 H2AC18 EPRS1
25 spinal disease 10.6 RNU4ATAC PRODH MIR9-1 MIR140 H2AC18
26 heart septal defect 10.6 RNU4ATAC PRODH H2AC18 FGF8
27 integumentary system disease 10.6 PRODH MIR9-1 MIR140 H2AC18 ERCC6 EPRS1
28 cerebral degeneration 10.6 SHH PRODH H2AC18 ERCC6 EPRS1 B3GNT2
29 autosomal recessive disease 10.6 RNU4ATAC PRODH H2AC18 ERCC6 EPRS1 B3GNT2
30 glucose metabolism disease 10.6 PRODH MIR9-1 MIR140 H2AC18 EPRS1
31 x-linked recessive disease 10.6 PRODH H2AC18 ERCC6 EPRS1
32 midline interhemispheric variant of holoprosencephaly 10.6 ZIC2 SHH FGF8
33 bone development disease 10.6 SHH RNU4ATAC H2AC18 FGF8
34 septopreoptic holoprosencephaly 10.6 ZIC2 SHH FGF8
35 central nervous system disease 10.6 PRODH MIR9-1 MIR140 H2AC18 ERCC6 EPRS1
36 inherited metabolic disorder 10.6 PRODH MTHFR MIR9-1 H2AC18 EPRS1
37 acquired metabolic disease 10.6 PRODH MIR9-1 MIR140 H2AC18 EPRS1
38 sensory system disease 10.6 RNU4ATAC PRODH MIR9-1 MIR140 H2AC18 ERCC6
39 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.6 RNU4ATAC PRODH MIR9-1 MIR140 H2AC18 ERCC6
40 holoprosencephaly 4 10.6 ZIC2 SHH FGF8
41 seckel syndrome 4 10.6 MCPH1 CENPJ CDK5RAP2 ASPM
42 alobar holoprosencephaly 10.6 ZIC2 SHH FGF8
43 microcephaly 11, primary, autosomal recessive 10.6 WDR62 MCPH1 CENPJ
44 respiratory system disease 10.6 PRODH MIR9-1 MIR140 H2AC18 ERCC6 EPRS1
45 autoimmune disease of the nervous system 10.6 PRODH MIR9-1 MIR140 H2AC18
46 lobar holoprosencephaly 10.6 ZIC2 SHH FGF8
47 seckel syndrome 2 10.6 MCPH1 CENPJ CDK5RAP2
48 cleft lip and alveolus 10.6 MSX1 IRF6
49 immune system disease 10.6 PRODH MIR9-1 MIR140 H2AC18 EPRS1
50 urinary system disease 10.6 PRODH MIR9-1 MIR140 H2AC18 ERCC6

Graphical network of the top 20 diseases related to Physical Disorder:



Diseases related to Physical Disorder

Symptoms & Phenotypes for Physical Disorder

UMLS symptoms related to Physical Disorder:


illness (finding)

GenomeRNAi Phenotypes related to Physical Disorder according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.55 IRF6
2 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.55 FGF8
3 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.55 FGF8
4 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.55 FGF8
5 Increased shRNA abundance (Z-score > 2) GR00366-A-155 9.55 B3GNT2 IRF6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.55 IRF6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.55 FGF8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.55 FGF8
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.55 FGF8
10 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.55 IRF6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.55 IRF6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.55 FGF8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.55 IRF6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.55 FGF8
15 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.55 B3GNT2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 FGF8

MGI Mouse Phenotypes related to Physical Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.31 ASPM B3GNT2 CDK5RAP2 CENPJ EPRS1 ERCC6
2 cellular MP:0005384 10.29 ASPM B3GNT2 CDK5RAP2 CENPJ EPRS1 ERCC6
3 endocrine/exocrine gland MP:0005379 10.09 ASPM CENPJ FGF8 MCPH1 MSX1 PAFAH1B1
4 craniofacial MP:0005382 10.06 B3GNT2 CDK5RAP2 CENPJ FGF8 IRF6 MSX1
5 nervous system MP:0003631 10 ASPM B3GNT2 CDK5RAP2 CENPJ ERCC6 FGF8
6 integument MP:0010771 9.97 CDK5RAP2 ERCC6 IRF6 MCPH1 MSX1 MTHFR
7 limbs/digits/tail MP:0005371 9.96 CENPJ EPRS1 ERCC6 FGF8 IRF6 MSX1
8 hearing/vestibular/ear MP:0005377 9.85 ERCC6 FGF8 IRF6 MCPH1 MSX1 SHH
9 skeleton MP:0005390 9.73 CDK5RAP2 CENPJ EPRS1 ERCC6 FGF8 IRF6
10 vision/eye MP:0005391 9.32 CDK5RAP2 CENPJ ERCC6 FGF8 MCPH1 MSX1

Drugs & Therapeutics for Physical Disorder

Drugs for Physical Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved 15687-27-1 3672
2 interferons
3 Antidepressive Agents
4 insulin
5 Insulin, Globin Zinc

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) For Newly Diagnosed Thyroid Cancer Patients: Randomized Controlled Trial Withdrawn NCT01994200 Phase 1, Phase 2
2 Reducing Depressive Symptoms in Physically Ill Youth Completed NCT00534911
3 Leader's Eye Tracking Patterns Changes During High Fidelity Simulation Scenarios of Postpartum Hemorrhage Completed NCT04395963
4 Treatment of Depressed Adolescents With Physical Illness Completed NCT00446238
5 Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness Completed NCT00769353
6 Study of Arsha Vidya Chhatralaya Initiative on Health and Functioning of Disadvantaged Tribal Children Completed NCT03578159
7 Relation Between Depression, Genes, Cytokines, Chronic Fatigue, Physical Illnesses and Quality of Life Completed NCT02943330
8 Effectiveness of a Supported Self-Care Intervention for Depression Compared to an Unsupported Intervention in Older Adults With Chronic Physical Illnesses (DIRECT-sc) Completed NCT01521013
9 Study Of Telemedicine Consultation at Home For Older Adults Completed NCT01324687
10 Influence of Kinesiology Taping Application on Severity of Signs and Symptoms in Breast Engorgement at Early Lactation Stage. Recruiting NCT03985579
11 HoloSIM: The Way Forward in Complex Crisis Training Not yet recruiting NCT04591041
12 Evaluation of a Simulation-Based Educational Tool for Personalized Feedback in Insulin Therapy Management Terminated NCT01767831

Search NIH Clinical Center for Physical Disorder

Genetic Tests for Physical Disorder

Anatomical Context for Physical Disorder

MalaCards organs/tissues related to Physical Disorder:

40
Breast, Eye, Thyroid, Brain, Cortex, Kidney, Spinal Cord

Publications for Physical Disorder

Articles related to Physical Disorder:

(show top 50) (show all 3140)
# Title Authors PMID Year
1
Is a school's neighborhood physical disorder related to its academic outcomes? 61
33767573 2021
2
How leisure activities affect health: a narrative review and multi-level theoretical framework of mechanisms of action. 61
33581775 2021
3
Predicting suicidal behavior and self-harm after general hospitalization of adults with serious mental illness. 61
33218748 2021
4
Follow the money: how is medical school teaching funded? 61
32654674 2021
5
Family Talk versus usual services in improving child and family psychosocial functioning in families with parental mental illness (PRIMERA-Promoting Research and Innovation in Mental hEalth seRvices for fAmilies and children): study protocol for a randomised controlled trial. 61
33794971 2021
6
Early external-environmental and internal-health predictors of risky sexual and aggressive behavior in adolescence: An integrative approach. 61
32869286 2021
7
Prevention of depression in adults with long-term physical conditions. 61
33667319 2021
8
Effectiveness of a Psychoeducational Group Intervention Carried Out by Nurses for Patients with Depression and Physical Comorbidity in Primary Care: Randomized Clinical Trial. 61
33805664 2021
9
Relationship of substance dependence and time to RT-PCR negative status in patients with COVID-19 infection. 61
33571916 2021
10
Poor Oral Health in Patients with Schizophrenia: a Meta-Analysis of Case-Control Studies. 61
32483766 2021
11
Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis. 61
33601681 2021
12
Comparative systematic review of the psychometric properties of measures of illness perceptions in family members of individuals diagnosed with a chronic physical illness. 61
32004398 2021
13
Neighborhood Social Cohesion, Physical Disorder, and Daily Activity Limitations Among Community-Dwelling Older Adults. 61
33242733 2021
14
Health-related quality of life among survivors in minority area 2 years after Jiuzhaigou earthquake: A cross-sectional study. 61
33725900 2021
15
Depressed Older Patients with Death Wishes: Experimental Evidence for Psychotherapists' Age and Health Bias. 61
33275085 2021
16
Addiction psychiatry and addiction medicine - Strange bedfellows or separated at birth? 61
33689603 2021
17
Surveillance of suicide deaths involving gases in Australia using the National Coronial Information System, 2006 to 2017. 61
33749955 2021
18
Editorial: The Cost of Comorbid Child Psychiatric Disorders: A National Call to Achieve the Triple Aim for Child Mental Health Care. 61
33310159 2021
19
Evaluation of an exercise physiology service in a youth mental health service. 61
32811583 2021
20
The biopsychosocial associations between marital hostility and physical health of middle-aged couples. 61
33661683 2021
21
Cancer Bereavement and Depression Symptoms in Older Spouses: The Possible Modifying Role of the Circadian Rest-Activity Rhythm. 61
32856562 2021
22
Midlife family financial strain, sense of control and pain in later years: An investigation of rural husbands and wives. 61
33687801 2021
23
Mindfulness meditation program for the elderly in Korea: A preliminary review for planning the program. 61
32913703 2021
24
[COVID- and Social Distancing Related Worries and their Relationship to Mental and Physical Illness]. 61
33601472 2021
25
Social Capital Effects on the Relation between Neighborhood Characteristics and Intimate Partner Violence Victimization among Women. 61
32996025 2021
26
High Risk and Trajectories of Physical Illnesses before the Diagnosis of Bipolar Disorder. 61
33310452 2021
27
Hospital admissions for dental disorders in patients with severe mental illness in Southeast London: A register-based cohort study. 61
33538014 2021
28
An Examination of Downward Drift as an Explanation of the Relationship Between Childhood Maltreatment and Residence in Unhealthy Neighborhoods in Adulthood: The Role of Psychiatric Symptoms. 61
33534178 2021
29
Prevalence and risk factors of perinatal depression among women in rural Bihar: A community-based cross-sectional study. 61
33454561 2021
30
Development and Validation of the Ethicotherapy Quality of Life Questionnaire. 61
32797341 2021
31
The COVID-19 Pandemic as a Traumatic Stressor: Mental Health Responses of Older Adults With Chronic PTSD. 61
33153871 2021
32
Childhood adversity and physical health among Asian Indian emerging adults in the United States: Exploring disease-specific vulnerabilities and the role of anger. 61
32969701 2021
33
How Stigma and Discrimination Influences Nursing Care of Persons Diagnosed with Mental Illness: A Systematic Review. 61
32762576 2021
34
Poverty transitions in severe mental illness: longitudinal analysis of social drift in China, 1994-2015. 61
33618792 2021
35
Research progress of heat stroke during 1989-2019: a bibliometric analysis. 61
33472705 2021
36
The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. 61
33436761 2021
37
Visual cues of the built environment and perceived stress among a cohort of black breast cancer survivors. 61
33383367 2021
38
The Association between Neighborhood Disorder and Health: Exploring the Moderating Role of Genotype and Marriage. 61
33494231 2021
39
[Mental Distress and Resilience in Severe Somatic Diseases: An Analysis of Dyadic Relations]. 61
32340059 2021
40
Identifying risk factors and detection strategies for adolescent depression in diverse global settings: A Delphi consensus study. 61
33039776 2021
41
Lower Health Literacy of Mania Than Depression Among Older People: A Random Survey of a Community Healthcare Service Center. 61
33776809 2021
42
A repeated-measures examination of organizational stressors, perceived psychological and physical health, and perceived performance in semi-elite athletes. 61
32851916 2021
43
Can employment in a café change Clientele Attitude towards the staff when they are Persons with Mental Illness? 61
33506712 2021
44
Adverse childhood experiences and health among indigenous persons experiencing homelessness. 61
33413243 2021
45
Food for thought: the importance of nutritional well-being during COVID-19. 61
33455607 2021
46
Indigenous Alaskan and mainstream identification explain the link between perceived discrimination and acculturative stress. 61
33399032 2021
47
Delirium occurrence in older Irish adults admitted to an acute medical hospital: a prospective cohort study. 61
33455597 2021
48
"Our Beauty Is in Our Breasts": A Culture-Centered Approach to Understanding Cancer Perceptions in Kwa Zulu Natal, South Africa. 61
32996437 2021
49
Confirming diagnostic categories within a depression continuum: Testing extra-linearity of risk factors and a latent class analysis. 61
33059221 2021
50
Perceived Neighborhood Environment Associated With Older Adults' Walking and Positive Affect: Results From the Health and Retirement Study. 61
33333489 2020

Variations for Physical Disorder

Expression for Physical Disorder

Search GEO for disease gene expression data for Physical Disorder.

Pathways for Physical Disorder

Pathways related to Physical Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 SHH MSX1 FGF8
2 9.91 SHH FGF8

GO Terms for Physical Disorder

Cellular components related to Physical Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 centrosome GO:0005813 9.35 WDR62 PAFAH1B1 CENPJ CDK5RAP2 ASPM
2 microtubule organizing center GO:0005815 9.02 WDR62 PAFAH1B1 MCPH1 CENPJ CDK5RAP2

Biological processes related to Physical Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.85 ZIC2 PAFAH1B1 CDK5RAP2 ASPM
2 ciliary basal body-plasma membrane docking GO:0097711 9.73 PAFAH1B1 CENPJ CDK5RAP2
3 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.67 PAFAH1B1 CENPJ CDK5RAP2
4 roof of mouth development GO:0060021 9.65 SHH MSX1 IRF6
5 neurogenesis GO:0022008 9.63 WDR62 ERCC6 CDK5RAP2
6 neuroblast proliferation GO:0007405 9.57 SHH PAFAH1B1
7 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.54 MSX1 FGF8
8 branching involved in salivary gland morphogenesis GO:0060445 9.52 SHH FGF8
9 microtubule organizing center organization GO:0031023 9.51 PAFAH1B1 CDK5RAP2
10 odontogenesis GO:0042476 9.5 SHH MSX1 FGF8
11 maintenance of centrosome location GO:0051661 9.43 PAFAH1B1 ASPM
12 establishment of mitotic spindle orientation GO:0000132 9.43 PAFAH1B1 MCPH1 CDK5RAP2
13 mesenchymal cell proliferation GO:0010463 9.4 SHH MSX1
14 regulation of odontogenesis GO:0042481 9.37 SHH MSX1
15 embryonic hindlimb morphogenesis GO:0035116 9.33 SHH MSX1 FGF8
16 centriole replication GO:0007099 9.13 WDR62 CENPJ CDK5RAP2
17 cerebral cortex development GO:0021987 8.92 WDR62 PAFAH1B1 MCPH1 ASPM

Sources for Physical Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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