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MCID: PHY002
MIFTS: 42

Physical Disorder

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Physical Disorder

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MalaCards integrated aliases for Physical Disorder:

Name: Physical Disorder 12 15
Physical Illness 72

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0080015
UMLS 72 C0683323
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Summaries for Physical Disorder

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Disease Ontology : 12 A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

MalaCards based summary : Physical Disorder, also known as physical illness, is related to agnathia-otocephaly complex and syngnathia, and has symptoms including illness (finding) An important gene associated with Physical Disorder is RNU4ATAC (RNA, U4atac Small Nuclear (U12-Dependent Splicing)), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dopamine and Bupropion have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are growth/size/body region and behavior/neurological

Wikipedia : 75 A physical disorder (as a medical term) is often used as a term in contrast to a mental disorder, in an... more...

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Related Diseases for Physical Disorder

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Diseases related to Physical Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 agnathia-otocephaly complex 32.3 SHH MSX1 DCX
2 syngnathia 32.2 MSX1 IRF6
3 orofacial cleft 31.9 TMEM54 SMCP NHLH1 MSX1 IRF6
4 cleft lip and alveolus 10.9 MSX1 IRF6
5 tooth size 10.9 SHH MSX1
6 chromosome 17p13.3, centromeric, duplication syndrome 10.9 PAFAH1B1 DCX
7 midline interhemispheric variant of holoprosencephaly 10.8 ZIC2 SHH
8 septopreoptic holoprosencephaly 10.8 ZIC2 SHH
9 isolated cleft lip 10.8 MSX1 IRF6
10 lissencephaly, x-linked, 1 10.8 PAFAH1B1 DCX
11 microcephaly 13, primary, autosomal recessive 10.8 WDR62 MCPH1
12 alobar holoprosencephaly 10.8 ZIC2 SHH
13 lobar holoprosencephaly 10.8 ZIC2 SHH
14 cleft lip 10.8 MTHFR MSX1 IRF6
15 testicular infarct 10.8 MTHFR AFP
16 neuronal migration disorders 10.8 WDR62 PAFAH1B1 DCX
17 cleft lip/palate 10.8 MTHFR MSX1 IRF6
18 lissencephaly with cerebellar hypoplasia 10.8 PAFAH1B1 DCX
19 microcephaly 17, primary, autosomal recessive 10.8 WDR62 MCPH1 CDK5RAP2
20 visceral heterotaxy 10.8
21 fetal alcohol spectrum disorder 10.8
22 renal-hepatic-pancreatic dysplasia 10.8
23 omphalocele 10.8
24 bladder exstrophy-epispadias-cloacal exstrophy complex 10.8
25 klippel-feil syndrome 10.8
26 hypospadias 10.8
27 patulous eustachian tube 10.8
28 microcephaly 12, primary, autosomal recessive 10.8 WDR62 MCPH1 CDK5RAP2
29 holoprosencephaly 4 10.8 ZIC2 SHH
30 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 10.7 WDR62 MCPH1 CDK5RAP2
31 schizencephaly 10.7 WDR62 SHH MTHFR
32 microcephaly 18, primary, autosomal dominant 10.7 WDR62 MCPH1 CDK5RAP2
33 hard palate cancer 10.7 TMEM54 SMCP MSX1
34 patau syndrome 10.7 ZIC2 AFP
35 microcephaly 3, primary, autosomal recessive 10.7 MCPH1 CDK5RAP2
36 microcephaly 5, primary, autosomal recessive 10.7 WDR62 MCPH1 CDK5RAP2 ASPM
37 microcephaly 7, primary, autosomal recessive 10.7 WDR62 SHH MCPH1 CDK5RAP2
38 primary autosomal recessive microcephaly 10.7 WDR62 MCPH1 CDK5RAP2 ASPM
39 lissencephaly 1 10.7 PAFAH1B1 DCX
40 primary microcephaly 10.7 WDR62 MCPH1 CDK5RAP2 ASPM
41 microform holoprosencephaly 10.6 ZIC2 SHH
42 microcephaly 6, primary, autosomal recessive 10.6 MCPH1 CDK5RAP2
43 cleft palate with or without ankyloglossia, x-linked 10.5 SMCP MSX1
44 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.4 SHH MSX1
45 microcephaly 10.4 WDR62 SHH RNU4ATAC MCPH1 ERCC6 CDK5RAP2
46 cleft palate, isolated 10.4 TMEM54 SMCP NHLH1 MTHFR MSX1 IRF6
47 sertoli-leydig cell tumor 10.3 INSL3 AFP
48 congenital nervous system abnormality 10.2 ZIC2 WDR62 SHH RNU4ATAC PAFAH1B1 MCPH1
49 anxiety 10.0
50 major affective disorder 8 9.9

Graphical network of the top 20 diseases related to Physical Disorder:



Diseases related to Physical Disorder
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Symptoms & Phenotypes for Physical Disorder

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UMLS symptoms related to Physical Disorder:


illness (finding)

MGI Mouse Phenotypes related to Physical Disorder:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.21 ASPM CDK5RAP2 DCX ERCC6 IRF6 MCPH1
2 behavior/neurological MP:0005386 10.19 AFP DCX ERCC6 INSL3 MCPH1 MSX1
3 cellular MP:0005384 10.18 ASPM CDK5RAP2 ERCC6 INSL3 IRF6 MCPH1
4 mortality/aging MP:0010768 10.1 AFP CDK5RAP2 DCX ERCC6 IRF6 MCPH1
5 endocrine/exocrine gland MP:0005379 10.06 AFP ASPM INSL3 MCPH1 MSX1 PAFAH1B1
6 nervous system MP:0003631 10.03 ASPM CDK5RAP2 DCX ERCC6 MCPH1 MSX1
7 integument MP:0010771 10.01 CDK5RAP2 ERCC6 IRF6 MCPH1 MSX1 MTHFR
8 limbs/digits/tail MP:0005371 9.85 ERCC6 IRF6 MSX1 MTHFR SHH ZIC2
9 reproductive system MP:0005389 9.85 AFP ASPM CDK5RAP2 DCX INSL3 MCPH1
10 skeleton MP:0005390 9.61 CDK5RAP2 ERCC6 INSL3 IRF6 MCPH1 MSX1
11 vision/eye MP:0005391 9.17 CDK5RAP2 ERCC6 MCPH1 MSX1 MTHFR SHH
Sources

Drugs & Therapeutics for Physical Disorder

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Drugs for Physical Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
3
Metformin Approved Phase 4 657-24-9 4091 14219
4
Nitrazepam Approved Phase 4 146-22-5 4506
5
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
6
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
7
Flunitrazepam Approved, Illicit Phase 4 1622-62-4 3380
8
Flurazepam Approved, Illicit, Investigational Phase 4 17617-23-1 3393
9
Estazolam Approved, Illicit Phase 4 29975-16-4 3261
10
Ethanol Approved Phase 4 64-17-5 702
11
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
12
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
13
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
14
Lithium carbonate Approved Phase 4 554-13-2
15
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
17
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
18
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
19 Antipsychotic Agents Phase 4
20 Neurotransmitter Agents Phase 4
21 Serotonin Uptake Inhibitors Phase 4
22 Antidepressive Agents Phase 4
23 Neurotransmitter Uptake Inhibitors Phase 4
24 Peripheral Nervous System Agents Phase 4
25 Serotonin Agents Phase 4
26 Psychotropic Drugs Phase 4
27 Autonomic Agents Phase 4
28 Dopamine Agents Phase 4
29 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
30 Cytochrome P-450 Enzyme Inhibitors Phase 4
31 Dopamine agonists Phase 4
32 Dopamine Uptake Inhibitors Phase 4
33 Tranquilizing Agents Phase 4
34 Central Nervous System Depressants Phase 4
35 Hypnotics and Sedatives Phase 4
36 Quetiapine Fumarate Phase 4 111974-72-2
37 Micronutrients Phase 4
38 Trace Elements Phase 4
39 Vitamins Phase 4
40 Vitamin B9 Phase 4
41 Vitamin B 6 Phase 4
42 Folate Phase 4
43 Vitamin B3 Phase 4
44 Vitamin B Complex Phase 4
45 Nicotinic Acids Phase 4
46 Lipid Regulating Agents Phase 4
47 Hypolipidemic Agents Phase 4
48 Nutrients Phase 4
49 Vasodilator Agents Phase 4
50 Antimetabolites Phase 4

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease: A Novel Adjunctive Therapy for Chronic Inflammatory Illness Completed NCT02162862 Phase 4 bupropion-SR
2 Metformin in the Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (METS) - Pilot Study Completed NCT00816907 Phase 4 Metformin;Placebo
3 Effects of Discontinuation of Benzodiazepine-derivative Hypnotics on Cognitive and Motor Functions in Elderly Persons: a Pilot Study Completed NCT00707915 Phase 4 Drug: Benzodiazepine (listed out below)
4 12 Week Prospective Double Blind Placebo Controlled Randomized Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR
5 The Treatment of Acute Schizophrenia With High Dose Niacinmide Plus Ascorbate Plus Pyridoxine Plus Centrum Forte vs. Centrum Forte Only as an Add-On to Risperidone and Dietary Counseling Completed NCT00140166 Phase 4 niacinamide;pyridoxine;ascorbate
6 Comparison of Combination Olanzapine and Lithium and Combination Chlorpromazine and Lithium in the Treatment of a First Manic Episode With Psychotic Features. Completed NCT00202293 Phase 4 Olanzapine;Lithium;Chlorpromazine
7 A Phase III Study of SEP-190 (Eszopiclone) in Patients With Insomnia Completed NCT00770692 Phase 3 Eszopiclone 1 mg- Elderly;Eszopiclone 2 mg- Elderly;Eszopiclone 3 mg- Non-elderly;Eszopiclone 2 mg- Non-elderly
8 The Effect of Fish Oil in Major Depressive Disorder: a Double-blind Placebo-controlled Monotherapy Trail to Demonstrate the Therapeutic Effects of Depression Completed NCT01371383 Phase 2, Phase 3
9 Phase III Open Study of High Dose Escitalopram for the Treatment of Obsessive-Compulsive Disorder in Adults Completed NCT00305500 Phase 3 escitalopram
10 Valnoctamide as a Valproate Substitute With Low Teratogenic Potential: Double-Blind Controlled Clinical Trial Completed NCT00140179 Phase 3 valnoctamide
11 Phase III Study of Maintenance Treatment for Opiate Dependence With Heroin (Diamorphine) Compared to Methadone Completed NCT00268814 Phase 3 Diacetylmorphine;Methadone
12 Electroacupuncture for Major Depression: A Pilot Study Completed NCT00071110 Phase 2
13 Cardiovascular System in Obesity: Effect of Treatment Completed NCT00000506 Phase 2 fenfluramine;phentermine
14 Vagal Nerve Stimulation to Probe Inflammation and Brain in Post-traumatic Stress Recruiting NCT03858985 Phase 1, Phase 2
15 Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer Terminated NCT03010761 Phase 2 escitalopram;Moclobemide;Placebo - Cap
16 Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) For Newly Diagnosed Thyroid Cancer Patients: Randomized Controlled Trial Withdrawn NCT01994200 Phase 1, Phase 2
17 A Pilot Investigational Study: Treatment of Anxiety With Non-Needle Electro-Acupuncture Completed NCT00335946 Phase 1
18 A Bioequivalence Study of Different Formulations of SEP-190 and Food Effect Study in Japanese Healthy Adult Males Completed NCT01055834 Phase 1 Eszopiclone 3 mg;Eszopiclone 1 mg
19 Treatment of Marijuana Withdrawal Syndrome Using Escitalopram and Cognitive-Behavior Therapy- a Double-Blind Placebo-Controlled Study Unknown status NCT00598052 Escitalopram
20 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
21 Investigating Neuroimaging Endophenotypes for Autism Spectrum Disorder Unknown status NCT02720588
22 Physical Health of Residents in Psychiatric Institutions Unknown status NCT00969384
23 Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation A Double-Blind, Placebo-Controlled, Fixed-Dose,Randomized Controlled Study Unknown status NCT00656552 Early Phase 1 Escitalopram
24 The Development of a Psychoeducation Tool to Manage Anxiety in People With Autism Spectrum Disorders: the Managing Anxiety iN Autism GuidE (MANAGE) Unknown status NCT02797379
25 A Randomized Controlled Trial Evaluation of Brief, Telephone Supported CBT Self-help in Primary Care Patients With Mild to Moderate Depression Unknown status NCT01324648
26 Changes in Methylation Status of BDNF Gene After Receiving Dialectical Behavior Therapy in Patients With Borderline Personality Disorder Unknown status NCT02134223
27 Treatment of Depressed Adolescents With Physical Illness Completed NCT00446238
28 Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness Completed NCT00769353
29 Improving Health and Reducing Disability of Depressed Elderly With Chronic Conditions Through Qigong Exercise: A Randomized Controlled Trial Completed NCT03591198
30 Proper Nutrition, Physical Exercise and Appropriate Weight in Individuals With Long Term Mental Illness Completed NCT00474227
31 Study of Arsha Vidya Chhatralaya Initiative on Health and Functioning of Disadvantaged Tribal Children Completed NCT03578159
32 Efficacy of Dialectical Behavior Therapy in Patients With Borderline Personality Disorder: a Controlled Trial in Taiwan Completed NCT01952405
33 Functional Rehabilitation of Older Patients With Schizophrenia Completed NCT00237796
34 Addressing Motion and Confounds Issues in Resting fMRI- Application of Multi-echo EPI Scanning Completed NCT02720562
35 Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour Completed NCT02615405
36 Get Moving and Get Well: A Behavioral Activation Program for Veterans With SMI Completed NCT01884025
37 The Clinical Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts: A Randomized Controlled Trial Completed NCT01512433
38 A Helping Hand (AHH) to Activate Patient-Centered Depression Care Among Low-Income Patients Completed NCT02147522
39 Effect of Psychoeducational Group Therapy Model for Bipolar Disorder Patients Completed NCT01152034
40 The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study Completed NCT02421146
41 IVR-based Cognitive Behavior Therapy for Chronic Low Back Completed NCT01025752
42 Hyperbaric Oxygenation in Treatment of Alcohol Dependence Syndrome Completed NCT03470168
43 Physician Training to Support Patient Self-Efficacy for Depression Care Behaviors Completed NCT01618552
44 Development of an Internet-based Behavioral Pain Management Intervention Completed NCT01918189
45 Cancer Caregiver Burden: Targeting Emotion Regulation in a Randomized Controlled Trial Completed NCT02322905
46 The Effect of Cigarette Holders, Plastic Menthol Cigarettes, and Cognitive Behavioral Therapy for Smoking Reduction Among Schizophrenia Inpatients: A Comparative Study Completed NCT00302432
47 Integrated Care & Patient Navigators for Latinos With Serious Mental Illness Completed NCT02469714
48 Wonders & Worries: A Clinical Trial of a Psychosocial Intervention for Children Who Have a Parent With Cancer Completed NCT02758639
49 Internet-Enhanced Management of Fibromyalgia Completed NCT00423631
50 Brief Chair-Side Mindfulness Intervention for Depression and Anxiety Symptoms in Patients Undergoing Dialysis: A Pilot Randomized Control Trial With an Active Control Group Completed NCT03406845

Search NIH Clinical Center for Physical Disorder

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Genetic Tests for Physical Disorder

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Anatomical Context for Physical Disorder

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MalaCards organs/tissues related to Physical Disorder:

41
Brain, Testes, Heart, Breast, Thyroid, Kidney, Cortex
Sources

Publications for Physical Disorder

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Articles related to Physical Disorder:

(show top 50) (show all 2905)
# Title Authors PMID Year
1
Internet-delivered cognitive-behavioral therapy for significant others of treatment-refusing problem gamblers: A randomized wait-list controlled trial. 38
31403816 2019
2
Effects of chronic physical illness on treatment outcomes among patients with schizophrenia. 38
31169534 2019
3
Neighborhood Context and the Risk for Developmental Disabilities in Early Childhood. 38
31209617 2019
4
Do human subject safeguards matter to potential participants in psychiatric genetic research? 38
31226581 2019
5
Physical and mental health problems of self-employed small business owners in South Korea. 38
31328810 2019
6
Excessive daytime sleepiness in medical students of Hunan province: Prevalence, correlates, and its relationship with suicidal behaviors. 38
31146220 2019
7
A Local View of Informal Urban Environments: a Mobile Phone-Based Neighborhood Audit of Street-Level Factors in a Brazilian Informal Community. 38
30887375 2019
8
Homeless Veterans in Nursing Homes: Care for Complex Medical, Substance Use, and Social Needs. 38
31206592 2019
9
Social exclusion of people with severe mental illness in Switzerland: results from the Swiss Health Survey. 38
29233203 2019
10
Social determinants of health in mental health care and research: a case for greater inclusion. 38
31329877 2019
11
Combined impacts of multimorbidity and mental disorders on frequent emergency department visits: a retrospective cohort study in Quebec, Canada. 38
31266786 2019
12
A Retrospective Chart Review of Screening on the Prevalence of Metabolic Syndrome (MetS) in an Irish Community Mental Health Service. 38
31295053 2019
13
Understanding self-harm in older adults: A qualitative study. 38
31388663 2019
14
Peer support: A needs assessment for social support from trained peers in response to stress among medical physicists. 38
31355990 2019
15
Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis. 38
31178367 2019
16
Chronicity of mental comorbidity in children with new-onset physical illness. 38
30982997 2019
17
A multilevel model of life satisfaction among old people: individual characteristics and neighborhood physical disorder. 38
31269940 2019
18
Prevalence of Chronic Health Conditions in Australian Adults with Depression and/or Anxiety. 38
31283353 2019
19
What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review. 38
30618044 2019
20
Prison primary care and non-communicable diseases: a data-linkage survey of prevalence and associated risk factors. 38
31366674 2019
21
Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea. 38
31319340 2019
22
Minding the treatment gap: results of the Singapore Mental Health Study. 38
31317246 2019
23
The effect of nutrition on older people's mental health. 38
31264453 2019
24
Differences in Characteristics and Exposure to Stressors Between Persons With and Without Diagnosed Mental Illness Who Died by Suicide in Victoria, Australia. 38
30311798 2019
25
Factors associated with emergency department use for mental health reasons among low, moderate and high users. 38
31404825 2019
26
Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors. 38
30985448 2019
27
Hospitalisation of people with dementia: evidence from English electronic health records from 2008 to 2016. 38
30649705 2019
28
Comorbidity of Physical Disorders Among Patients With Severe Mental Illness With and Without Substance Use Disorders: A Systematic Review and Meta-Analysis. 38
31164045 2019
29
Utilization of somatic healthcare in Croatian patients with schizophrenia spectrum disorder, major depression, PTSD and the general population. 38
31253196 2019
30
Physical illness leading to absence from work and the risk of subsequent suicide: a national register-based study. 38
31168583 2019
31
Using decision trees to understand the influence of individual- and neighborhood-level factors on urban diabetes and asthma. 38
31203032 2019
32
Recovery in homelessness: The influence of choice and mastery on physical health, psychiatric symptoms, alcohol and drug use, and community integration. 38
30730171 2019
33
Effectiveness of a psychoeducation group intervention conducted by primary healthcare nurses in patients with depression and physical comorbidity: study protocol for a randomized, controlled trial. 38
31242892 2019
34
A personal account of depressive illness and its antidepressant treatment. 38
31261181 2019
35
Understanding which people with dementia are at risk of inappropriate care and avoidable transitions to hospital near the end-of-life: a retrospective cohort study. 38
31135024 2019
36
Study of electronic records from a south London psychiatric trust suggests that the increased mortality from physical illness linked to depression varies between ethnic groups. 38
31142570 2019
37
Negative emotions and chronic physical illness: A lifespan developmental perspective. 38
31135166 2019
38
Heart Rate Variability Biofeedback Increased Autonomic Activation and Improved Symptoms of Depression and Insomnia among Patients with Major Depression Disorder. 38
30905122 2019
39
Why are somatic diseases in bipolar disorder insufficiently treated? 38
31055668 2019
40
Prevalence of comorbid mental and physical illnesses and risks for self-harm and premature death among primary care patients diagnosed with fatigue syndromes. 38
31131782 2019
41
Triparesis: an unusual presentation of factitious disorder. 38
31076490 2019
42
Patterns of Health Insurance Discontinuity and Children's Access to Health Care. 38
30600518 2019
43
Safety Planning to Manage Suicide Risk with Older Adults: Case Examples and Recommendations. 38
31096885 2019
44
Are non-psychiatric hospitalisations before self-harm associated with an increased risk for suicide among young people? 38
30929715 2019
45
Physical Health Literacy and Health-related Behaviors in Patients with Psychosis. 38
30905128 2019
46
Outcomes from a One-Week Adapted Sport and Adapted Adventure Recovery Programme for Military Personnel. 38
31159281 2019
47
Test of a clinical model of poor physical health and suicide: The role of depression, psychosocial stress, interpersonal conflict, and panic. 38
31306991 2019
48
Somatic and anxiety symptoms of depression are associated with disability in late life depression. 38
30945553 2019
49
Major Depressive Disorder in Medical Illness: A Review of Assessment, Prevalence, and Treatment Options. 38
30720699 2019
50
Pharmacotherapeutic strategies for treating binge eating disorder. Evidence from clinical trials and implications for clinical practice. 38
30696303 2019
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Variations for Physical Disorder

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Expression for Physical Disorder

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Search GEO for disease gene expression data for Physical Disorder.
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Pathways for Physical Disorder

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Pathways related to Physical Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.05 SHH MSX1 IRF6 AFP
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GO Terms for Physical Disorder

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Cellular components related to Physical Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic spindle pole GO:0097431 8.96 CDK5RAP2 ASPM
2 microtubule GO:0005874 8.92 PAFAH1B1 DCX CDK5RAP2 ASPM

Biological processes related to Physical Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.7 SHH NHLH1 DCX
2 neuron migration GO:0001764 9.63 PAFAH1B1 DCX ASPM
3 positive regulation of neuroblast proliferation GO:0002052 9.55 SHH ASPM
4 brain development GO:0007420 9.55 ZIC2 PAFAH1B1 DCX CDK5RAP2 ASPM
5 neuronal stem cell population maintenance GO:0097150 9.54 MCPH1 ASPM
6 neuroblast proliferation GO:0007405 9.51 SHH PAFAH1B1
7 centriole replication GO:0007099 9.48 WDR62 CDK5RAP2
8 layer formation in cerebral cortex GO:0021819 9.43 PAFAH1B1 DCX
9 microtubule organizing center organization GO:0031023 9.4 PAFAH1B1 CDK5RAP2
10 maintenance of centrosome location GO:0051661 9.37 PAFAH1B1 ASPM
11 mesenchymal cell proliferation GO:0010463 9.32 SHH MSX1
12 regulation of odontogenesis GO:0042481 9.26 SHH MSX1
13 transcription by RNA polymerase II GO:0006366 9.19 ERCC6
14 establishment of mitotic spindle orientation GO:0000132 9.13 PAFAH1B1 MCPH1 CDK5RAP2
15 cerebral cortex development GO:0021987 8.92 WDR62 PAFAH1B1 MCPH1 ASPM
16 multicellular organism development GO:0007275 10.03 ZIC2 SHH PAFAH1B1 NHLH1 MSX1 DCX
Sources

Sources for Physical Disorder

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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