Aliases & Classifications for Physical Disorder

MalaCards integrated aliases for Physical Disorder:

Name: Physical Disorder 12 15
Physical Illness 74


External Ids:

Disease Ontology 12 DOID:0080015
UMLS 74 C0683323

Summaries for Physical Disorder

Disease Ontology : 12 A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

MalaCards based summary : Physical Disorder, also known as physical illness, is related to agnathia-otocephaly complex and syngnathia, and has symptoms including illness (finding) An important gene associated with Physical Disorder is RNU4ATAC (RNA, U4atac Small Nuclear (U12-Dependent Splicing)), and among its related pathways/superpathways are Cytoskeletal Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dopamine and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are growth/size/body region and behavior/neurological

Wikipedia : 77 A physical disorder (as a medical term) is often used as a term in contrast to a mental disorder, in an... more...

Related Diseases for Physical Disorder

Diseases related to Physical Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 agnathia-otocephaly complex 31.6 DCX MSX1 SHH
2 syngnathia 31.4 IRF6 MSX1
3 orofacial cleft 31.4 IRF6 MSX1 NHLH1 SMCP TMEM54
4 visceral heterotaxy 10.6
5 fetal alcohol spectrum disorder 10.6
6 renal-hepatic-pancreatic dysplasia 10.6
7 omphalocele 10.6
8 bladder exstrophy-epispadias-cloacal exstrophy complex 10.6
9 klippel-feil syndrome 10.6
10 hypospadias 10.6
11 patulous eustachian tube 10.6
12 chromosome 17p13.3, centromeric, duplication syndrome 10.6 DCX PAFAH1B1
13 cleft lip and alveolus 10.5 IRF6 MSX1
14 tooth size 10.5 MSX1 SHH
15 anorchia 10.5 INSL3 RXFP2
16 pachygyria 10.5 PAFAH1B1 TUBA1A
17 holoprosencephaly 4 10.5 GLI3 SHH ZIC2
18 septopreoptic holoprosencephaly 10.5 SHH ZIC2
19 holoprosencephaly 10.5 GLI3 SHH ZIC2
20 microcephaly 13, primary, autosomal recessive 10.5 MCPH1 WDR62
21 midline interhemispheric variant of holoprosencephaly 10.5 SHH ZIC2
22 microcephaly 17, primary, autosomal recessive 10.5 CDK5RAP2 MCPH1 WDR62
23 microcephaly 12, primary, autosomal recessive 10.4 CDK5RAP2 MCPH1 WDR62
24 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 10.4 CDK5RAP2 MCPH1 WDR62
25 primary autosomal recessive microcephaly 10.4 CDK5RAP2 MCPH1 WDR62
26 lissencephaly, x-linked, 1 10.4 DCX PAFAH1B1
27 microcephaly 18, primary, autosomal dominant 10.4 CDK5RAP2 MCPH1 WDR62
28 isolated cleft lip 10.4 IRF6 MSX1
29 hard palate cancer 10.4 MSX1 SMCP TMEM54
30 microcephaly 7, primary, autosomal recessive 10.4 CDK5RAP2 MCPH1 SHH WDR62
31 neuronal migration disorders 10.4 DCX FLNA PAFAH1B1 WDR62
32 band heterotopia 10.4 DCX FLNA PAFAH1B1 TUBA1A
33 periventricular nodular heterotopia 10.4 DCX FLNA PAFAH1B1 TUBA1A
34 primary microcephaly 10.4 CDK5RAP2 MCPH1 WDR62
35 alobar holoprosencephaly 10.4 SHH ZIC2
36 microcephaly 5, primary, autosomal recessive 10.4 CDK5RAP2 HIST2H2AA3 MCPH1 WDR62
37 lissencephaly with cerebellar hypoplasia 10.4 DCX PAFAH1B1
38 lissencephaly 10.4 DCX PAFAH1B1 TUBA1A
39 microcephaly 3, primary, autosomal recessive 10.3 CDK5RAP2 MCPH1
40 microcephaly 10.2 CDK5RAP2 ERCC6 MCPH1 RNU4ATAC SHH TUBA1A
41 cleft palate, isolated 10.1 FLNA HIST2H2AA3 IRF6 MSX1 NHLH1 SMCP
42 tooth agenesis 10.1 GLI3 IRF6 MSX1
43 congenital nervous system abnormality 10.0 CDK5RAP2 DCX FLNA MCPH1 PAFAH1B1 RNU4ATAC
44 anxiety 9.7
45 disease of mental health 9.7
46 tobacco addiction 9.5
47 smoking as a quantitative trait locus 3 9.5
48 alacrima, achalasia, and mental retardation syndrome 9.5
49 chronic mountain sickness 9.5
50 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.5

Graphical network of the top 20 diseases related to Physical Disorder:

Diseases related to Physical Disorder

Symptoms & Phenotypes for Physical Disorder

UMLS symptoms related to Physical Disorder:

illness (finding)

MGI Mouse Phenotypes related to Physical Disorder:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.3 CDK5RAP2 DCX ERCC6 FLNA GLI3 IRF6
2 behavior/neurological MP:0005386 10.29 DCX ERCC6 FLNA INSL3 MCPH1 MSX1
3 cellular MP:0005384 10.27 CDK5RAP2 ERCC6 FLNA GLI3 INSL3 IRF6
4 mortality/aging MP:0010768 10.1 CDK5RAP2 DCX ERCC6 FLNA GLI3 IRF6
5 nervous system MP:0003631 10.1 CDK5RAP2 DCX ERCC6 FLNA GLI3 MCPH1
6 integument MP:0010771 10.06 CDK5RAP2 ERCC6 GLI3 IRF6 MCPH1 MSX1
7 craniofacial MP:0005382 10.02 CDK5RAP2 FLNA GLI3 IRF6 MSX1 SHH
8 hearing/vestibular/ear MP:0005377 9.91 ERCC6 GLI3 IRF6 MCPH1 MSX1 SHH
9 limbs/digits/tail MP:0005371 9.85 ERCC6 GLI3 IRF6 MSX1 SHH ZIC2
10 reproductive system MP:0005389 9.85 CDK5RAP2 DCX FLNA GLI3 INSL3 MCPH1
11 skeleton MP:0005390 9.7 CDK5RAP2 ERCC6 FLNA GLI3 INSL3 IRF6
12 vision/eye MP:0005391 9.28 CDK5RAP2 ERCC6 FLNA GLI3 MCPH1 MSX1

Drugs & Therapeutics for Physical Disorder

Drugs for Physical Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dopamine Approved Phase 4,Not Applicable 62-31-7, 51-61-6 681
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
Lithium carbonate Approved Phase 4 554-13-2
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
6 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Not Applicable
7 Dopamine Antagonists Phase 4,Not Applicable
8 Autonomic Agents Phase 4,Phase 2,Not Applicable
9 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
10 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
11 Antidepressive Agents Phase 4,Phase 2,Not Applicable
12 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
13 Dopamine Agents Phase 4,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Antipsychotic Agents Phase 4,Not Applicable
16 Antidepressive Agents, Second-Generation Phase 4,Phase 2,Not Applicable
17 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Not Applicable
18 Serotonin Agents Phase 4,Phase 2,Not Applicable
19 Serotonin Uptake Inhibitors Phase 4,Phase 2,Not Applicable
20 Gastrointestinal Agents Phase 4
21 Antiemetics Phase 4
22 Antimanic Agents Phase 4
23 Dopamine Uptake Inhibitors Phase 4
24 Cytochrome P-450 Enzyme Inhibitors Phase 4
25 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
26 Dopamine agonists Phase 4
Serotonin Investigational, Nutraceutical Phase 4,Phase 2,Not Applicable 50-67-9 5202
tannic acid Approved Phase 3,Not Applicable 1401-55-4
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
Eszopiclone Approved, Investigational Phase 3,Phase 1 138729-47-2 969472
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
33 Hypnotics and Sedatives Phase 3,Phase 1
34 Anti-Anxiety Agents Phase 3
35 Analgesics Phase 3,Not Applicable
36 Calcium, Dietary Phase 3
37 calcium channel blockers Phase 3
38 Hormones Phase 3
39 Anticonvulsants Phase 3
Citalopram Approved Phase 2,Not Applicable 59729-33-8 2771
Moclobemide Approved, Investigational Phase 2 71320-77-9 4235
42 Antiparkinson Agents Phase 2,Not Applicable
43 Muscarinic Antagonists Phase 2,Not Applicable
44 Cholinergic Antagonists Phase 2,Not Applicable
45 Parasympatholytics Phase 2,Not Applicable
46 Cholinergic Agents Phase 2,Not Applicable
47 Monoamine Oxidase Inhibitors Phase 2
Amisulpride Approved, Investigational Not Applicable 71675-85-9, 53583-79-2 2159
Ethanol Approved Not Applicable 64-17-5 702
Nicotine Approved Not Applicable 54-11-5 89594 942

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features Completed NCT00202293 Phase 4 Olanzapine;Lithium;Chlorpromazine
2 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease Completed NCT02162862 Phase 4 bupropion-SR
3 CHANGE -it is About Life Completed NCT01585493 Phase 3
4 A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150) Completed NCT00770692 Phase 3 Eszopiclone 1 mg- Elderly;Eszopiclone 2 mg- Elderly;Eszopiclone 3 mg- Non-elderly;Eszopiclone 2 mg- Non-elderly
5 Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia Completed NCT01270828 Phase 3 Pregabalin;placebo
6 Detection and Treatment of Depression in Patients Admitted to the General Hospital Unknown status NCT00521911 Phase 2
7 Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer Terminated NCT03010761 Phase 2 escitalopram;Moclobemide;Placebo - Cap
8 Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) for Thyroid Cancer Patients Withdrawn NCT01994200 Phase 1, Phase 2
9 A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102) Completed NCT01055834 Phase 1 Eszopiclone 3 mg;Eszopiclone 1 mg
10 Sinovuyo Caring Families Project - Pilot Trial Completed NCT01802294 Phase 1
11 Effect of Combined Exercise Post-treatment Intervention in Lean Mass Recovery in Breast Cancer Survival. Unknown status NCT01843608 Not Applicable
12 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
13 Mind Body Therapy During Geriatric Rehabilitation Unknown status NCT01074788 Not Applicable
14 [18 Fluorine(F)]DOPA Determinants and Predictors of Treatment Response in Psychosis Unknown status NCT02880995 Not Applicable 6 weeks of treatment with amisulpride
15 Internet-Based Interventions for Bipolar Disorder Unknown status NCT02106078 Not Applicable
16 Treatment of Depressed Adolescents With Physical Illness Completed NCT00446238 Not Applicable
17 Effectiveness of a Self-care Intervention for Depression in Primary Care Patients With Chronic Physical Illnesses Completed NCT01521013 Not Applicable
18 Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness Completed NCT00769353 Not Applicable
19 Depression, Genes, Cytokines, Chronic Fatigue, Physical Illnesses and Quality of Life Completed NCT02943330
20 Efficacy of Neuromuscular Electrical Stimulation in Geriatric Population Completed NCT03409575 Not Applicable
21 Study Of Telemedicine Consultation at Home For Older Adults Completed NCT01324687
22 Influence of Multi-dimensional Wellness Program on Quality of Life Completed NCT01927250 Not Applicable
23 Laser Therapy, Pain and Carpometacarpal Joint Osteoarthritis Treatment Completed NCT03270488 Not Applicable
24 Safety/Effectiveness Study of a Single Session of Laying-on-of-hands in Various Settings in Japan Completed NCT01316029
25 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
26 Randomized Controlled Trial of Mind-Body Breathing Therapy (in Chronic Obstructive Pulmonary Disease) To Improve Palliation of Dyspnea and Health-Related Quality of Life Completed NCT00243282 Not Applicable
27 Auriculotherapy on Lower Urinary Tract Symptoms in Elderly Men Completed NCT02330107 Not Applicable
28 Study of Arsha Vidya Chhatralaya Initiative on Health and Functioning of Disadvantaged Tribal Children Completed NCT03578159
29 Role of Rehabilitation for the Repair of Pelvic Floor Injuries Associated to Vaginal Delivery Identified by 3/4D Transperineal Ultrasound Completed NCT03592160 Not Applicable
30 Life Quality and Health in Patients With Klinefelter Syndrome Completed NCT01690013
31 Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour Completed NCT02615405 Not Applicable
32 Evaluation of a Gamified Electronic Medication Administration Record (eMAR) System Completed NCT03219151 Not Applicable
33 Improving Health and Reducing Disability of Depressed Elderly With Chronic Conditions Through Qigong Exercise Completed NCT03591198 Not Applicable
34 Stress Management Program for World Trade Center (WTC) Responders Completed NCT02457780 Not Applicable
35 Get Moving and Get Well - Pilot Study Completed NCT01884025 Not Applicable
36 Cancer Caregiver Burden: Targeting Emotion Regulation in a Trial Completed NCT02322905 Not Applicable
37 The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study Completed NCT02421146 Not Applicable
38 Evaluation of Telehealth Interventions for Post-Trauma Stress Completed NCT00350584 Not Applicable
39 MAPS Group Therapy Model for Bipolar Disorder Completed NCT01152034 Not Applicable
40 The Effect of Patient and Investigator Expectation on the Efficacy of Escitalopram in the Treatment Depression Completed NCT02480400 Not Applicable Escitalopram;Escitalopram
41 Impact of Video Presentations on Medical Students' Attitudes Toward Mental Illness Completed NCT03231761 Not Applicable
42 Analgesic Current Therapies for Chronic Neck Pain Completed NCT03121859 Not Applicable
43 Spiroergometric and Psychological Measurements to Predict Return to Work After 18 and 36 Months After Medical Rehab Completed NCT03206307
44 The Effect of High Intensity Laser Therapy in the Management of Painful Calcaneal Spur Completed NCT03907085 Not Applicable
45 Reducing Stigma Among Healthcare Providers to Improve Mental Health Services Completed NCT02793271 Not Applicable
46 Internet-Based Interventions for Bipolar Disorder (MoodSwings 2) Completed NCT02118623 Not Applicable
47 Effectiveness Rehabilitation Hematopoietic Transplantation (ovERsHOT) Completed NCT03324620 Not Applicable
48 Repair by Rehabilitation of Pelvic Floor Lesions After Vaginal Delivery Identified by Transperineal Ultrasound 3/4 D Recruiting NCT03686956 Not Applicable
49 Communitas: A Program for Teens Living With Chronic Illness and Their Families Recruiting NCT03170167
50 Narrative Exposure Therapy in Patients With Psychotic Disorders and a Posttraumatic Stress Disorder Recruiting NCT03730831 Not Applicable

Search NIH Clinical Center for Physical Disorder

Genetic Tests for Physical Disorder

Anatomical Context for Physical Disorder

MalaCards organs/tissues related to Physical Disorder:

Brain, Testes, Heart, Thyroid, Eye, Cortex, Spinal Cord

Publications for Physical Disorder

Articles related to Physical Disorder:

(show top 50) (show all 475)
# Title Authors Year
Unique Effects of Perceived Neighborhood Physical Disorder and Social Cohesion on Episodic Memory and Semantic Fluency. ( 30715092 )
Chronicity of Mental Comorbidity in Children with New-onset Physical Illness. ( 30982997 )
The role of neighborhoods in household food insufficiency: Considering interactions between physical disorder, low social capital, violence, and perceptions of danger. ( 30557777 )
Effectiveness of mindfulness-based arts interventions on psychological wellbeing and fatigue in adults with a physical illness: a systematic review protocol. ( 29995707 )
Learning About the Management of Physical Illness During the Postgraduate Training to Become a Good Psychiatrist. ( 28875286 )
A cross-continental analysis of weight gain, psychiatric diagnoses and medication use during inpatient psychiatric treatment. The international study on physical illness in mentally ill. ( 29331602 )
Comorbidity of mental illness and chronic physical illness: A diagnostic and treatment conundrum. ( 29993137 )
Inequitable Physical Illness and Premature Mortality for People with Severe Mental Illness in Australia: A Social Analysis. ( 30008569 )
Lifetime Spousal Violence Victimization and Perpetration, Physical Illness, and Health Risk Behaviours among Women in India. ( 30518101 )
Neighborhood Physical Disorder and Psychological Distress. ( 27913760 )
Invited Commentary: Observing Neighborhood Physical Disorder in an Age of Technological Innovation. ( 28899029 )
Mooney et al. Respond to "Observing Neighborhood Physical Disorder". ( 28899030 )
The association of physical illness and self-harm resulting in hospitalisation among older people in a population-based study. ( 26471731 )
Chronic Physical Illness Burden and Suicidal Ideation Among Dominicans in New York City. ( 27507022 )
Systematic Review: Bullying Involvement of Children With and Without Chronic Physical Illness and/or Physical/Sensory Disability-a Meta-Analytic Comparison With Healthy/Nondisabled Peers. ( 27784727 )
Stigma of mental and physical illness and the use of mobile technology. ( 27841705 )
Physical illness in those with mental illness: psychiatric services need to change focus. ( 28052889 )
Ageing and mental health: changes in self-reported health due to physical illness and mental health status with consecutive cross-sectional analyses. ( 28100564 )
Gene-environment interplay in depressive symptoms: moderation by age, sex, and physical illness. ( 28202098 )
Exploring the effectiveness of couples interventions for adults living with a chronic physical illness: A systematic review. ( 28228340 )
Research Review: Childhood chronic physical illness and adult emotional health - a systematic review and meta-analysis. ( 28449285 )
Understanding the Progression from Physical Illness to Suicidal Behavior: A Case Study Based on a Newly Developed Conceptual Model. ( 28452674 )
Do US Medical Licensing Applications Treat Mental and Physical Illness Equivalently? ( 28633174 )
A systematic review and meta-analysis of written self-administered psychosocial interventions among adults with a physical illness. ( 28734559 )
Contributing to making the school a safe place for the child: School nurses' perceptions of their assignment when caring for children having parents with serious physical illness. ( 29085652 )
Social Origins of Developmental Risk for Mental and Physical Illness. ( 29118206 )
Attitudes towards assisted suicide and euthanasia among care-dependent older adults (50+) in Austria: the role of socio-demographics, religiosity, physical illness, psychological distress, and social isolation. ( 29212490 )
Functioning Among Youth with Comorbid Mood Disorder and Chronic Physical Illness in Public Sector Care. ( 27680986 )
Neighborhood Physical Disorder in New York City. ( 27482283 )
The role of neighborhood disadvantage, physical disorder, and collective efficacy in adolescent alcohol use: a multilevel path analysis. ( 27521816 )
On listening to the dreams of children affected by a serious physical illness. ( 26222810 )
A systematic review of physical illness, functional disability, and suicidal behaviour among older adults. ( 26381843 )
Assessing the role of physical illness in young old and older old suicide attempters. ( 26560405 )
Perceived barriers to and facilitators of labor market engagement for individuals with chronic physical illness in their experience with disability policy: a systematic review of qualitative evidence protocol. ( 26767816 )
Strategies to deal with comorbid physical illness in psychosis. ( 26888363 )
Depression predicts future emergency hospital admissions in primary care patients with chronic physical illness. ( 26919799 )
Chronic physical illness in early life and risk of chronic widespread and regional pain at age 68: evidence from the 1946 British birth cohort. ( 27547897 )
Psychogenic Explanations of Physical Illness: Time to Examine the Evidence. ( 27694458 )
Examining the relationship between physical illness and depression: Is there a difference between inflammatory and non inflammatory diseases? A cohort study. ( 27796262 )
Physical Illness in Gay, Lesbian, and Heterosexual Marriages: Gendered Dyadic Experiences. ( 27799592 )
The impact of chronic physical illness, maternal depressive symptoms, family functioning, and self-esteem on symptoms of anxiety and depression in children. ( 24938212 )
Days out of role due to mental and physical illness in the South African stress and health study. ( 25096982 )
Older men and older women remand prisoners: mental illness, physical illness, offending patterns and needs. ( 25428523 )
Improving the diagnosis of physical illness in patients with mental illness who present in emergency departments: consensus study. ( 25637525 )
In sickness and in health? Physical illness as a risk factor for marital dissolution in later life. ( 25722125 )
Prevention and treatment of psychiatric disorders in children with chronic physical illness. ( 25784735 )
Psychological interventions for mental health disorders in children with chronic physical illness: a systematic review. ( 25784736 )
Communication with patients suffering from serious physical illness. ( 25832510 )
Association between trajectories of maternal depression and subsequent psychological functioning in youth with and without chronic physical illness. ( 25844906 )
Tumour necrosis factor-α inhibitor therapy in chronic physical illness: A systematic review and meta-analysis of the effect on depression and anxiety. ( 25935351 )

Variations for Physical Disorder

Expression for Physical Disorder

Search GEO for disease gene expression data for Physical Disorder.

Pathways for Physical Disorder

Pathways related to Physical Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2 11.46 IRF6 MSX1 SHH
3 9.58 GLI3 SHH

GO Terms for Physical Disorder

Cellular components related to Physical Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 9.26 CDK5RAP2 DCX PAFAH1B1 TUBA1A
2 cytoskeleton GO:0005856 9.17 CDK5RAP2 DCX FLNA MCPH1 PAFAH1B1 TUBA1A

Biological processes related to Physical Disorder according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 G2/M transition of mitotic cell cycle GO:0000086 9.84 CDK5RAP2 PAFAH1B1 TUBA1A
2 anterior/posterior pattern specification GO:0009952 9.82 GLI3 MSX1 SHH
3 microtubule cytoskeleton organization GO:0000226 9.81 CDK5RAP2 PAFAH1B1 TUBA1A
4 ciliary basal body-plasma membrane docking GO:0097711 9.79 CDK5RAP2 PAFAH1B1 TUBA1A
5 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.78 CDK5RAP2 PAFAH1B1 TUBA1A
6 forebrain development GO:0030900 9.76 GLI3 MSX1 SHH
7 hippocampus development GO:0021766 9.75 DCX GLI3 PAFAH1B1
8 roof of mouth development GO:0060021 9.74 GLI3 MSX1 SHH
9 embryonic digit morphogenesis GO:0042733 9.72 GLI3 MSX1 SHH
10 odontogenesis of dentin-containing tooth GO:0042475 9.71 GLI3 MSX1 SHH
11 embryonic limb morphogenesis GO:0030326 9.7 GLI3 MSX1 SHH
12 anatomical structure formation involved in morphogenesis GO:0048646 9.67 GLI3 SHH
13 positive regulation of neuroblast proliferation GO:0002052 9.67 GLI3 SHH
14 spinal cord motor neuron differentiation GO:0021522 9.67 GLI3 SHH
15 central nervous system development GO:0007417 9.67 DCX GLI3 NHLH1 SHH
16 neuroblast proliferation GO:0007405 9.66 PAFAH1B1 SHH
17 centriole replication GO:0007099 9.65 CDK5RAP2 WDR62
18 embryonic digestive tract morphogenesis GO:0048557 9.65 GLI3 SHH
19 brain development GO:0007420 9.65 CDK5RAP2 DCX GLI3 PAFAH1B1 ZIC2
20 embryonic morphogenesis GO:0048598 9.63 GLI3 SHH
21 prostate gland development GO:0030850 9.62 GLI3 SHH
22 negative thymic T cell selection GO:0045060 9.61 GLI3 SHH
23 positive regulation of alpha-beta T cell differentiation GO:0046638 9.6 GLI3 SHH
24 microtubule organizing center organization GO:0031023 9.59 CDK5RAP2 PAFAH1B1
25 artery development GO:0060840 9.56 GLI3 SHH
26 mesenchymal cell proliferation GO:0010463 9.51 MSX1 SHH
27 positive regulation of protein import into nucleus GO:0042307 9.5 FLNA GLI3 SHH
28 spinal cord dorsal/ventral patterning GO:0021513 9.49 GLI3 SHH
29 hindgut morphogenesis GO:0007442 9.46 GLI3 SHH
30 regulation of odontogenesis GO:0042481 9.43 MSX1 SHH
31 negative regulation of alpha-beta T cell differentiation GO:0046639 9.4 GLI3 SHH
32 establishment of mitotic spindle orientation GO:0000132 9.33 CDK5RAP2 MCPH1 PAFAH1B1
33 cerebral cortex development GO:0021987 9.26 FLNA MCPH1 PAFAH1B1 WDR62
34 transcription by RNA polymerase II GO:0006366 9.18 ERCC6
35 layer formation in cerebral cortex GO:0021819 8.8 DCX GLI3 PAFAH1B1
36 positive regulation of transcription, DNA-templated GO:0045893 10.05 CDK5RAP2 GLI3 IRF6 SHH ZIC2
37 negative regulation of apoptotic process GO:0043066 10.03 FLNA GLI3 MSX1 RXFP2 SHH

Molecular functions related to Physical Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.92 GLI3 MSX1 NHLH1 ZIC2

Sources for Physical Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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