Aliases & Classifications for Physical Disorder

MalaCards integrated aliases for Physical Disorder:

Name: Physical Disorder 12 15
Physical Illness 73

External Ids:

Disease Ontology 12 DOID:0080015
UMLS 73 C0683323

Summaries for Physical Disorder

Disease Ontology : 12 A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

MalaCards based summary : Physical Disorder, also known as physical illness, is related to agnathia-otocephaly complex and acquired schizencephaly, and has symptoms including illness (finding) An important gene associated with Physical Disorder is RNU4ATAC (RNA, U4atac Small Nuclear (U12-Dependent Splicing)), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Tgif disruption of Shh signaling. The drugs Chlorpromazine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and thyroid, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 A physical disorder (as a medical term) is often used as a term in contrast to a mental disorder, in an... more...

Related Diseases for Physical Disorder

Diseases related to Physical Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 agnathia-otocephaly complex 31.9 MSX1 NODAL SHH
2 acquired schizencephaly 11.0 SHH SIX3
3 cleft lip and alveolus 11.0 IRF6 MSX1
4 maxillonasal dysplasia, binder type 10.9 SATB2 SHH
5 patau syndrome 10.9 NODAL SIX3 ZIC2
6 anus, imperforate 10.9 GLI3 SATB2 SHH
7 holoprosencephaly 4 10.9 GLI3 SHH ZIC2
8 septopreoptic holoprosencephaly 10.8 NODAL SHH SIX3 ZIC2
9 midline interhemispheric variant of holoprosencephaly 10.8 NODAL SHH SIX3 ZIC2
10 tooth size 10.8 MSX1 SHH
11 alobar holoprosencephaly 10.8 NODAL SHH SIX3 ZIC2
12 lobar holoprosencephaly 10.8 NODAL SHH SIX3 ZIC2
13 chromosome 18p deletion syndrome 10.8 NODAL SHH SIX3 ZIC2
14 hard palate cancer 10.8 MSX1 SHOX2 TMEM54
15 microform holoprosencephaly 10.8 NODAL SHH SIX3 ZIC2
16 semilobar holoprosencephaly 10.8 NODAL SHH SIX3 ZIC2
17 bone development disease 10.8 GLI3 PIK3R2 RNU4ATAC SHOX2
18 neuronal migration disorders 10.8 PAFAH1B1 WDR62
19 schizencephaly 10.8 SHH SIX3 WDR62
20 chromosome 2q35 duplication syndrome 10.8 GLI3 PIK3R2 SATB2
21 popliteal pterygium syndrome 10.7 IRF6 NHLH1 SATB2
22 pachygyria 10.7 PAFAH1B1 WDR62
23 holoprosencephaly 10.6 GLI3 NODAL SHH SIX3 ZIC2
24 tooth agenesis 10.5 GLI3 IRF6 MSX1 SATB2 TMEM54
25 isolated cleft lip 10.5 IRF6 MSX1
26 seckel syndrome 10.5 CEP63 MCPH1 RNU4ATAC
27 visceral heterotaxy 10.4
28 fetal alcohol spectrum disorder 10.4
29 renal-hepatic-pancreatic dysplasia 10.4
30 omphalocele 10.4
31 bladder exstrophy-epispadias-cloacal exstrophy complex 10.4
32 klippel-feil syndrome 10.4
33 hypospadias 10.4
34 patulous eustachian tube 10.4
35 cleft palate, isolated 10.4 IRF6 MSX1 NHLH1 SATB2 SHOX2 TMEM54
36 trehalase deficiency 10.4 CEP63 PAFAH1B1 PIK3R2 SATB2 TUBB3 WDR62
37 autosomal recessive primary microcephaly 10.2 MCPH1 WDR62
38 orofacial cleft 10.1 IRF6 MSX1 NHLH1 NODAL RPS17 SATB2
39 congenital nervous system abnormality 10.0 CEP63 MCPH1 NODAL PAFAH1B1 RNU4ATAC SHH
40 aging 9.7
41 paine syndrome 9.4
42 alacrima, achalasia, and mental retardation syndrome 9.4
43 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.4
44 alexithymia 9.4
45 disease of mental health 9.4
46 genital herpes 9.4

Graphical network of the top 20 diseases related to Physical Disorder:

Diseases related to Physical Disorder

Symptoms & Phenotypes for Physical Disorder

UMLS symptoms related to Physical Disorder:

illness (finding)

MGI Mouse Phenotypes related to Physical Disorder:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 NODAL PAFAH1B1 SATB2 SHH TUBB3 WDR62
2 cardiovascular system MP:0005385 10.26 GLI3 MCPH1 MSX1 NHLH1 NODAL PIK3R2
3 growth/size/body region MP:0005378 10.25 CEP63 GLI3 IRF6 MCPH1 MSX1 NODAL
4 craniofacial MP:0005382 10.15 MSX1 NODAL SATB2 SHH SHOX2 SIX3
5 digestive/alimentary MP:0005381 10.13 GLI3 IRF6 MSX1 NODAL SATB2 SHH
6 mortality/aging MP:0010768 10.13 GLI3 IRF6 MCPH1 MSX1 NHLH1 NODAL
7 embryo MP:0005380 10.11 GLI3 IRF6 MSX1 NODAL PAFAH1B1 SATB2
8 nervous system MP:0003631 10.1 CEP63 GLI3 MCPH1 MSX1 NHLH1 NODAL
9 endocrine/exocrine gland MP:0005379 10.09 WDR62 CEP63 GLI3 INSL3 MCPH1 MSX1
10 limbs/digits/tail MP:0005371 9.91 SHH SHOX2 ZIC2 GLI3 IRF6 MSX1
11 respiratory system MP:0005388 9.76 GLI3 MSX1 NODAL SATB2 SHH SIX3
12 skeleton MP:0005390 9.7 SHOX2 SIX3 ZIC2 GLI3 INSL3 IRF6
13 taste/olfaction MP:0005394 8.92 GLI3 NODAL SHH SIX3

Drugs & Therapeutics for Physical Disorder

Drugs for Physical Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
5 Antidepressive Agents Phase 4,Phase 2,Not Applicable
6 Antiemetics Phase 4
7 Antimanic Agents Phase 4
8 Antipsychotic Agents Phase 4,Not Applicable
9 Autonomic Agents Phase 4,Phase 2,Not Applicable
10 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Not Applicable
11 Dopamine Agents Phase 4,Not Applicable
12 Dopamine Antagonists Phase 4,Not Applicable
13 Gastrointestinal Agents Phase 4
14 Lithium carbonate Phase 4 554-13-2
15 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
16 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Not Applicable
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
19 Serotonin Agents Phase 4,Phase 2,Not Applicable
20 Serotonin Uptake Inhibitors Phase 4,Phase 2,Not Applicable
21 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
22 Antidepressive Agents, Second-Generation Phase 4,Phase 2,Not Applicable
23 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
24 Cytochrome P-450 Enzyme Inhibitors Phase 4
25 Dopamine agonists Phase 4
26 Dopamine Uptake Inhibitors Phase 4
Serotonin Investigational, Nutraceutical Phase 4,Phase 2,Not Applicable 50-67-9 5202
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
Eszopiclone Approved, Investigational Phase 3,Phase 1 138729-47-2 969472
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
31 tannic acid Approved, Nutraceutical Phase 3,Not Applicable
32 Hypnotics and Sedatives Phase 3,Phase 1
33 Analgesics Phase 3,Not Applicable
34 Anti-Anxiety Agents Phase 3
35 Anticonvulsants Phase 3
36 calcium channel blockers Phase 3
37 Calcium, Dietary Phase 3
Citalopram Approved Phase 2,Not Applicable 59729-33-8 2771
Moclobemide Approved, Investigational Phase 2 71320-77-9 4235
40 Antiparkinson Agents Phase 2,Not Applicable
41 Cholinergic Agents Phase 2,Not Applicable
42 Cholinergic Antagonists Phase 2,Not Applicable
43 Muscarinic Antagonists Phase 2,Not Applicable
44 Parasympatholytics Phase 2,Not Applicable
45 Monoamine Oxidase Inhibitors Phase 2
Menthol Approved Not Applicable 2216-51-5 16666
Ethanol Approved Not Applicable 64-17-5 702
Nicotine Approved Not Applicable 54-11-5 942 89594
Sulpiride Approved, Investigational Not Applicable 15676-16-1 5355
50 interferons

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features Unknown status NCT00202293 Phase 4 Olanzapine;Lithium;Chlorpromazine
2 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease Completed NCT02162862 Phase 4 bupropion-SR
3 CHANGE -it is About Life Completed NCT01585493 Phase 3
4 A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150) Completed NCT00770692 Phase 3 Eszopiclone 1 mg- Elderly;Eszopiclone 2 mg- Elderly;Eszopiclone 3 mg- Non-elderly;Eszopiclone 2 mg- Non-elderly
5 Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia Completed NCT01270828 Phase 3 Pregabalin;placebo
6 Detection and Treatment of Depression in Patients Admitted to the General Hospital Unknown status NCT00521911 Phase 2
7 Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer Terminated NCT03010761 Phase 2 escitalopram;Moclobemide;Placebo - Cap
8 Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) for Thyroid Cancer Patients Withdrawn NCT01994200 Phase 1, Phase 2
9 A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102) Completed NCT01055834 Phase 1 Eszopiclone 3 mg;Eszopiclone 1 mg
10 Sinovuyo Caring Families Project - Pilot Trial Completed NCT01802294 Phase 1
11 Effect of Combined Exercise Post-treatment Intervention in Lean Mass Recovery in Breast Cancer Survival. Unknown status NCT01843608 Not Applicable
12 Get Moving and Get Well - Pilot Study Unknown status NCT01884025 Not Applicable
13 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
14 Mind Body Therapy During Geriatric Rehabilitation Unknown status NCT01074788 Not Applicable
15 Internet-Based Interventions for Bipolar Disorder Unknown status NCT02106078 Not Applicable
16 Treatment of Depressed Adolescents With Physical Illness Completed NCT00446238 Not Applicable
17 Effectiveness of a Self-care Intervention for Depression in Primary Care Patients With Chronic Physical Illnesses Completed NCT01521013 Not Applicable
18 Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness Completed NCT00769353 Not Applicable
19 Depression, Genes, Cytokines, Chronic Fatigue, Physical Illnesses and Quality of Life Completed NCT02943330
20 Efficacy of Neuromuscular Electrical Stimulation in Geriatric Population Completed NCT03409575 Not Applicable
21 Study Of Telemedicine Consultation at Home For Older Adults Completed NCT01324687
22 Laser Therapy, Pain and Carpometacarpal Joint Osteoarthritis Treatment Completed NCT03270488 Not Applicable
23 Influence of Multi-dimensional Wellness Program on Quality of Life Completed NCT01927250 Not Applicable
24 Safety/Effectiveness Study of a Single Session of Laying-on-of-hands in Various Settings in Japan Completed NCT01316029
25 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
26 Randomized Controlled Trial of Mind-Body Breathing Therapy (in Chronic Obstructive Pulmonary Disease) To Improve Palliation of Dyspnea and Health-Related Quality of Life Completed NCT00243282 Not Applicable
27 Auriculotherapy on Lower Urinary Tract Symptoms in Elderly Men Completed NCT02330107 Not Applicable
28 Study of Arsha Vidya Chhatralaya Initiative on Health and Functioning of Disadvantaged Tribal Children Completed NCT03578159
29 Life Quality and Health in Patients With Klinefelter Syndrome Completed NCT01690013
30 Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour Completed NCT02615405 Not Applicable
31 Evaluation of a Gamified Electronic Medication Administration Record (eMAR) System Completed NCT03219151 Not Applicable
32 Stress Management Program for World Trade Center (WTC) Responders Completed NCT02457780 Not Applicable
33 The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study Completed NCT02421146 Not Applicable
34 Evaluation of Telehealth Interventions for Post-Trauma Stress Completed NCT00350584 Not Applicable
35 Mindful Mental Training for Surgeons to Enhance Resilience and Performance Under Stress Completed NCT03141190 Not Applicable
36 MAPS Group Therapy Model for Bipolar Disorder Completed NCT01152034 Not Applicable
37 The Effect of Patient and Investigator Expectation on the Efficacy of Escitalopram in the Treatment Depression Completed NCT02480400 Not Applicable Escitalopram;Escitalopram
38 Analgesic Current Therapies for Chronic Neck Pain Completed NCT03121859 Not Applicable
39 Internet-Based Interventions for Bipolar Disorder (MoodSwings 2) Completed NCT02118623 Not Applicable
40 Effectiveness Rehabilitation Hematopoietic Transplantation (ovERsHOT) Completed NCT03324620 Not Applicable
41 Communitas: A Program for Teens Living With Chronic Illness and Their Families Recruiting NCT03170167
42 Peer Navigators to Address Obesity-Related Concerns for African Americans With Serious Mental Illness Recruiting NCT03382782 Not Applicable
43 Enhanced Stress Resilience Training for Faculty Recruiting NCT03516877 Not Applicable
44 Impact of Video Presentations on Medical Students' Attitudes Toward Mental Illness Recruiting NCT03231761 Not Applicable
45 Spiroergometric and Psychological Measurements to Predict Return to Work After 18 and 36 Months After Medical Rehab Recruiting NCT03206307
46 Reducing Stigma Among Healthcare Providers to Improve Mental Health Services Recruiting NCT02793271 Not Applicable
47 Implementation of Transdx Group for POTS Recruiting NCT03185247 Not Applicable
48 User-centred Assistive System for Arm Functions in Neuromuscular Subjects Recruiting NCT03127241 Not Applicable
49 Reducing Depressive Symptoms in Physically Ill Youth Active, not recruiting NCT00534911 Not Applicable
50 Cancer Caregiver Burden: Targeting Emotion Regulation in a Trial Active, not recruiting NCT02322905 Not Applicable

Search NIH Clinical Center for Physical Disorder

Genetic Tests for Physical Disorder

Anatomical Context for Physical Disorder

MalaCards organs/tissues related to Physical Disorder:

Brain, Testes, Thyroid, Eye

Publications for Physical Disorder

Articles related to Physical Disorder:

(show all 27)
# Title Authors Year
Invited Commentary: Observing Neighborhood Physical Disorder in an Age of Technological Innovation. ( 28899029 )
The role of neighborhood disadvantage, physical disorder, and collective efficacy in adolescent alcohol use: a multilevel path analysis. ( 27521816 )
Neighborhood Physical Disorder and Psychological Distress: Does the Risk Increase With Age? ( 27913760 )
Neighborhood Physical Disorder in New York City. ( 27482283 )
Neighborhood physical disorder, social cohesion, and insomnia: results from participants over age 50 in the Health and Retirement Study. ( 25222023 )
Validity of an ecometric neighborhood physical disorder measure constructed by virtual street audit. ( 25122584 )
The alexithymic brain: the neural pathways linking alexithymia to physical disorders. ( 23302233 )
Social cohesion and self-rated health: The moderating effect of neighborhood physical disorder. ( 24048811 )
Intellectual disability and co-occurring mental health and physical disorders in aggressive behaviour. ( 23952483 )
Child maltreatment increases sensitivity to adverse social contexts: neighborhood physical disorder and incident binge drinking in Detroit. ( 21981990 )
Erratum on "Eyes on the block: Measuring urban physical disorder through in person observation, by Malia Jones, Anne R. Pebley, Narayan Sastry, Social Science Research 40 (2) 523-537". ( 23017767 )
Do children with developmental disabilities and mental health conditions have greater difficulty using health services than children with physical disorders? ( 20364366 )
Eyes on the Block: Measuring Urban Physical Disorder Through In-Person Observation. ( 21643484 )
Misdemeanor policing, physical disorder, and gun-related homicide: a spatial analytic test of "broken-windows" theory. ( 19525689 )
The association of sidewalk walkability and physical disorder with area-level race and poverty. ( 17933956 )
Review of aetiological concepts of temporomandibular pain disorders: towards a biopsychosocial model for integration of physical disorder factors with psychological and psychosocial illness impact factors. ( 15978854 )
Block observations of neighbourhood physical disorder are associated with neighbourhood crime, firearm injuries and deaths, and teen births. ( 16166368 )
Well sibling psychological adjustment to chronic physical disorder in a sibling: how important is maternal awareness of their illness attitudes and perceptions? ( 11693590 )
Physical disorder and optical properties in the vacuum ultraviolet region of amorphous SiO(2). ( 11690278 )
Excessive health behaviors in those at risk for physical disorder. ( 9304547 )
Emotional coping, age, and physical disorder. ( 2364177 )
Psychological investigation of genital herpes recurrence: prospective assessment and cognitive-behavioral intervention for a chronic physical disorder. ( 3383831 )
Type A behavior as a general risk factor for physical disorder. ( 3050117 )
The other part of the elephant. Mental disorder screening in primary health care settings and physical disorder screening in psychiatric settings. ( 3431175 )
Detection of physical disorder in newly admitted psychiatric patients. ( 3812010 )
Physical disorder among day hospital patients. ( 667504 )
Physical Disorder in 164 Admissions to a Mental Hospital. ( 20780853 )

Variations for Physical Disorder

Expression for Physical Disorder

Search GEO for disease gene expression data for Physical Disorder.

Pathways for Physical Disorder

Pathways related to Physical Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes

GO Terms for Physical Disorder

Biological processes related to Physical Disorder according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.96 GLI3 MCPH1 SATB2 SHH
2 brain development GO:0007420 9.89 GLI3 NODAL PAFAH1B1 SIX3 ZIC2
3 central nervous system development GO:0007417 9.88 GLI3 NHLH1 SHH
4 lung development GO:0030324 9.85 GLI3 NODAL SHH
5 heart development GO:0007507 9.85 GLI3 MSX1 NODAL SHH SHOX2
6 forebrain development GO:0030900 9.83 GLI3 MSX1 SHH
7 cerebral cortex development GO:0021987 9.82 MCPH1 PAFAH1B1 WDR62
8 negative regulation of cell differentiation GO:0045596 9.82 GLI3 NODAL SHH
9 camera-type eye development GO:0043010 9.81 GLI3 SHH SIX3
10 multicellular organism development GO:0007275 9.81 MSX1 NHLH1 NODAL PAFAH1B1 SATB2 SHH
11 embryonic digit morphogenesis GO:0042733 9.8 GLI3 MSX1 SHH
12 cell development GO:0048468 9.8 IRF6 NODAL SHH
13 odontogenesis of dentin-containing tooth GO:0042475 9.78 GLI3 MSX1 SHH
14 anterior/posterior pattern specification GO:0009952 9.73 GLI3 MSX1 NODAL SHH
15 embryonic forelimb morphogenesis GO:0035115 9.71 MSX1 SHH SHOX2
16 spinal cord motor neuron differentiation GO:0021522 9.7 GLI3 SHH
17 positive regulation of neuroblast proliferation GO:0002052 9.7 GLI3 SHH
18 positive regulation of protein import into nucleus GO:0042307 9.7 GLI3 PIK3R2 SHH
19 establishment of mitotic spindle orientation GO:0000132 9.69 MCPH1 PAFAH1B1
20 osteoblast development GO:0002076 9.69 SATB2 SHH
21 neuroblast proliferation GO:0007405 9.69 PAFAH1B1 SHH
22 prostate gland development GO:0030850 9.68 GLI3 SHH
23 centriole replication GO:0007099 9.68 CEP63 WDR62
24 digestive tract morphogenesis GO:0048546 9.67 NODAL SHH
25 layer formation in cerebral cortex GO:0021819 9.67 GLI3 PAFAH1B1
26 negative thymic T cell selection GO:0045060 9.66 GLI3 SHH
27 positive regulation of alpha-beta T cell differentiation GO:0046638 9.65 GLI3 SHH
28 embryonic pattern specification GO:0009880 9.65 NODAL SATB2 SHH
29 artery development GO:0060840 9.64 GLI3 SHH
30 forebrain dorsal/ventral pattern formation GO:0021798 9.62 GLI3 SIX3
31 roof of mouth development GO:0060021 9.62 GLI3 MSX1 SATB2 SHH
32 telencephalon regionalization GO:0021978 9.61 SHH SIX3
33 spinal cord dorsal/ventral patterning GO:0021513 9.6 GLI3 SHH
34 mesenchymal cell proliferation GO:0010463 9.59 MSX1 SHH
35 regulation of odontogenesis GO:0042481 9.58 MSX1 SHH
36 anatomical structure formation involved in morphogenesis GO:0048646 9.58 GLI3 NODAL SHH
37 hindgut morphogenesis GO:0007442 9.57 GLI3 SHH
38 formation of anatomical boundary GO:0048859 9.56 NODAL SHH
39 negative regulation of alpha-beta T cell differentiation GO:0046639 9.55 GLI3 SHH
40 embryonic digestive tract morphogenesis GO:0048557 9.54 GLI3 SHH SHOX2
41 embryonic morphogenesis GO:0048598 9.43 GLI3 SHH SHOX2
42 positive regulation of transcription by RNA polymerase II GO:0045944 9.32 GLI3 IRF6 MSX1 NHLH1 NODAL PIK3R2
43 embryonic limb morphogenesis GO:0030326 9.26 GLI3 MSX1 SHH SHOX2
44 regulation of transcription, DNA-templated GO:0006355 10.34 GLI3 IRF6 MSX1 NHLH1 SATB2 SHH
45 nervous system development GO:0007399 10.07 NODAL PAFAH1B1 SHOX2 WDR62 ZIC2
46 transcription by RNA polymerase II GO:0006366 10.06 GLI3 IRF6 MSX1 NHLH1 SATB2 SIX3
47 negative regulation of transcription by RNA polymerase II GO:0000122 10.05 GLI3 MCPH1 MSX1 NODAL SATB2 SHH

Molecular functions related to Physical Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.56 GLI3 MSX1 NHLH1 SATB2
2 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.56 GLI3 IRF6 MSX1 NHLH1 SATB2 SHOX2
3 morphogen activity GO:0016015 9.16 NODAL SHH
4 sequence-specific DNA binding GO:0043565 9.1 GLI3 IRF6 MSX1 SATB2 SHOX2 SIX3

Sources for Physical Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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