Physical Urticaria disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Physical Urticaria

MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria ¹² ⁷⁶ ¹⁵

Symptomatic Dermographism ⁷³

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060220

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Summaries for Physical Urticaria

Disease Ontology : ¹² An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to cholinergic urticaria and urticaria, and has symptoms including darier's sign and integumentary system signs and symptoms. An important gene associated with Physical Urticaria is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Sphingolipid signaling pathway and TRP channels. The drugs Cetirizine and Desloratadine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related phenotype is immune system.

Wikipedia : ⁷⁶ Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

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Related Diseases for Physical Urticaria

Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)

#	Related Disease	Score	Top Affiliating Genes
1	cholinergic urticaria	31.1	MS4A2 POLK RAX2
2	urticaria	29.9	ADGRE2 FCER1A MS4A2
3	urticaria, aquagenic	11.0
4	solar urticaria	10.9
5	nasal cavity disease	10.1	MS4A2 TRPV1
6	nose disease	10.0	MS4A2 TRPV1
7	upper respiratory tract disease	10.0	MS4A2 TRPV1
8	angioedema	10.0
9	bronchial disease	9.9	MS4A2 TRPV1
10	hypersensitivity reaction disease	9.8	MS4A2 TRPV1
11	dentin sensitivity	9.8	TRPV1 TRPV3
12	cold urticaria	9.7
13	allergic hypersensitivity disease	9.6	FCER1A MS4A2 TRPV1
14	respiratory system disease	9.6	MS4A2 TRPV1
15	dermatographia	9.3	FCER1A MS4A2 OSMR

Graphical network of the top 20 diseases related to Physical Urticaria:

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Symptoms & Phenotypes for Physical Urticaria

UMLS symptoms related to Physical Urticaria:

darier's sign, integumentary system signs and symptoms

MGI Mouse Phenotypes related to Physical Urticaria:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.1	FCER1A MS4A2 OSMR POLK TRPV1 TRPV3

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Drugs & Therapeutics for Physical Urticaria

Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cetirizine

Approved

Phase 4

83881-51-0

2678

2

Desloratadine

Approved, Investigational

Phase 4

100643-71-8

124087

3

Ebastine

Approved, Investigational

Phase 4

90729-43-4

3191

4

Fexofenadine

Approved, Investigational

Phase 4

83799-24-0

3348

5

Histamine

Approved, Investigational

Phase 4

75614-87-8, 51-45-6

774

6

Anti-Allergic Agents

Phase 4,Phase 2

7

Cholinergic Agents

Phase 4

8

Cholinergic Antagonists

Phase 4

9

Histamine Antagonists

Phase 4,Phase 2

10

Histamine H1 Antagonists

Phase 4,Phase 2

11

Histamine H1 Antagonists, Non-Sedating

Phase 4

12

Histamine Phosphate

Phase 4

51-74-1

65513

13

Neurotransmitter Agents

Phase 4

14

Omalizumab

Approved, Investigational

Phase 2

242138-07-4

15

Anti-Asthmatic Agents

Phase 2

16

Antibodies

Phase 2

17

Antibodies, Monoclonal

Phase 2

18

Immunoglobulins

Phase 2

19

Respiratory System Agents

Phase 2

20

Dinoprostone

Approved

363-24-6

5280360

21

Levocetirizine

Approved

130018-77-8

1549000

22

Serine

Approved, Nutraceutical

56-45-1

5951

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria	Completed	NCT01940393	Phase 4	Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2	Bilastine Updosing in Chronic Spontaneous Urticaria	Completed	NCT02213367	Phase 3	Bilastine;Bilastine;Bilastin
3	Urticaria Facticia Treatment With Omalizumab (UFO)	Completed	NCT02169115	Phase 2	Omalizumab;Omalizumab;Placebo
4	Cold Urticaria Treatment With Xolair	Completed	NCT01580592	Phase 2	Omalizumab;Omalizumab;Placebo
5	Phase II Solar Urticaria (SU) Pilot Study	Completed	NCT00859534	Phase 2	afamelanotide
6	Cold Contact Urticaria Treatment With Rilonacept	Active, not recruiting	NCT02171416	Phase 2	Rilonacept;Placebo
7	Pathogenesis of Physical Induced Urticarial Syndromes	Recruiting	NCT00887939
8	The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism	Terminated	NCT01008592		levocetirizine or placebo

Search NIH Clinical Center for Physical Urticaria

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Genetic Tests for Physical Urticaria

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Anatomical Context for Physical Urticaria

MalaCards organs/tissues related to Physical Urticaria:

⁴¹

Skin, Testes

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Publications for Physical Urticaria

Articles related to Physical Urticaria:

(show all 25)

#	Title	Authors	Year
1	Food-dependent cold urticaria: A new variant of physical urticaria. ( 29698807 )	Kulthanan K....Maurer M.	2018
2	Epidemiology of urticaria including physical urticaria and angioedema in Korea. ( 29742892 )	Seo J.H....Kwon J.W.	2018
3	Physical urticaria. ( 28433981 )	English J....Bajaj K.	2017
4	Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. ( 27585061 )	Cuervo-Pardo L....Lang D.M.	2016
5	Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. ( 26012951 )	Netchiporouk E....Ben-Shoshan M.	2015
6	Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. ( 25959894 )	Trevisonno J....Ben-Shoshan M.	2015
7	Physical urticarias and cholinergic urticaria. ( 24262690 )	Abajian M....Maurer M.	2014
8	Dissociation between history and challenge in patients with physical urticaria. ( 25439372 )	Komarow H.D....Metcalfe D.D.	2014
9	Contemporary approaches to the diagnosis and management of physical urticaria. ( 24054356 )	Lang D.M....Bernstein J.A.	2013
10	Physical urticaria. ( 22653630 )	Abajian M....Maurer M.	2012
11	Periorbital physical urticaria in an anophthalmic patient with dermatographism. ( 21217333 )	Gupta S....Ahmad A.Z.	2011
12	Use of a ballpoint pen in the diagnosis of physical urticaria. ( 21572812 )	Godse K.V.	2011
13	Physical urticaria: prevalence, type and natural course in a tropical country. ( 21175877 )	Silpa-archa N....Pinkaew S.	2011
14	Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. ( 20733327 )	Metz M....Maurer M.	2011
15	Clinical features and natural history of physical urticaria in children. ( 18167159 )	Khakoo G....Lack G.	2008
16	Physical urticaria. ( 15120149 )	Dice J.P.	2004
17	A comprehensive review of physical urticaria. ( 12506491 )	Muller B.A.	2002
18	Pathomechanisms in physical urticaria. ( 11764299 )	Grabbe J.	2001
19	Physical urticaria: classification and diagnostic guidelines. An EAACI position paper. ( 9201361 )	Kontou-Fili K....Mitchel F.B.	1997
20	Physical urticaria: a common misdiagnosis. ( 8933536 )	Scott C.B....Moloney M.F.	1996
21	Evaluation of three skin tests in physical urticaria. ( 3145842 )	Zhu T.C.	1988
22	Physical urticaria. ( 4092383 )	Sibbald R.G.	1985
23	Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin. ( 7022724 )	Soter N.A.	1981
24	Physical urticaria/angioedema: an experimental model of mast cell activation in humans. ( 7002977 )	Soter N.A....Wasserman S.I.	1980
25	Physical urticaria and sport. ( 891255 )	Mikhailov P....Andreev V.C.	1977

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Genes for Physical Urticaria

Genes related to Physical Urticaria (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	18.64	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	ADGRE2	Adhesion G Protein-Coupled Receptor E2	Protein Coding	17.76	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	RAX2	Retina And Anterior Neural Fold Homeobox 2	Protein Coding	16.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	FCER1A	Fc Fragment Of IgE Receptor Ia	Protein Coding	15.49	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	15.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	OSMR	Oncostatin M Receptor	Protein Coding	15.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	TRPV3	Transient Receptor Potential Cation Channel Subfamily V Member 3	Protein Coding	14.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	POLK	DNA Polymerase Kappa	Protein Coding	14.75	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Physical Urticaria

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Expression for Physical Urticaria

Search GEO for disease gene expression data for Physical Urticaria.

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Pathways for Physical Urticaria

Pathways related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Sphingolipid signaling pathway ³⁷	11.03	FCER1A MS4A2
2	TRP channels ⁶⁶	10.02	TRPV1 TRPV3

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GO Terms for Physical Urticaria

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.33	ADGRE2 MS4A2 TRPV1
2	response to heat	GO:0009408	8.96	TRPV1 TRPV3
3	cell surface receptor signaling pathway	GO:0007166	8.8	ADGRE2 MS4A2 TRPV1

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium channel activity	GO:0005262	9.16	TRPV1 TRPV3
2	cation channel activity	GO:0005261	8.96	TRPV1 TRPV3
3	IgE binding	GO:0019863	8.62	FCER1A MS4A2

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Sources for Physical Urticaria

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia