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MCID: PHY008
MIFTS: 30

Physical Urticaria

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Physical Urticaria

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MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria 12 77 15 17
Symptomatic Dermographism 74

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060220
UMLS 74 C0343065
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Summaries for Physical Urticaria

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Disease Ontology : 12 An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to cholinergic urticaria and urticaria, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Physical Urticaria is ADGRE2 (Adhesion G Protein-Coupled Receptor E2), and among its related pathways/superpathways is Sphingolipid signaling pathway. The drugs Fexofenadine and Ebastine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Wikipedia : 77 Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

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Related Diseases for Physical Urticaria

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Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cholinergic urticaria 31.6 MS4A2 RAX2
2 urticaria 30.7 ADGRE2 FCER1A
3 urticaria, aquagenic 11.2
4 solar urticaria 11.1
5 angioedema 10.1
6 cold urticaria 9.8
7 dermatographia 9.4 CDSN FCER1A MS4A2

Graphical network of the top 20 diseases related to Physical Urticaria:



Diseases related to Physical Urticaria
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Symptoms & Phenotypes for Physical Urticaria

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UMLS symptoms related to Physical Urticaria:


integumentary system signs and symptoms, darier's sign
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Drugs & Therapeutics for Physical Urticaria

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Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
2
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
3
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
4
Histamine Approved, Investigational Phase 4 51-45-6 774
5
Cetirizine Approved Phase 4 83881-51-0 2678
6 Histamine H1 Antagonists Phase 4,Phase 2
7 Histamine Antagonists Phase 4,Phase 2
8 Cholinergic Antagonists Phase 4
9
Histamine Phosphate Phase 4 51-74-1 65513
10 Anti-Allergic Agents Phase 4,Phase 2
11 Cholinergic Agents Phase 4
12 Histamine H1 Antagonists, Non-Sedating Phase 4
13 Neurotransmitter Agents Phase 4
14
Omalizumab Approved, Investigational Phase 2 242138-07-4
15
Rilonacept Approved, Investigational Phase 2 501081-76-1 104924
16
Afamelanotide Experimental, Investigational Phase 2 75921-69-6
17 Immunoglobulins Phase 2
18 Respiratory System Agents Phase 2
19 Anti-Asthmatic Agents Phase 2
20 Antibodies, Monoclonal Phase 2
21 Immunologic Factors Phase 2
22 Antibodies Phase 2
23 Anti-Inflammatory Agents Phase 2
24 Dermatologic Agents Phase 2
25
Ethanol Approved Not Applicable 64-17-5 702
26
Dinoprostone Approved 363-24-6 5280360
27
Levocetirizine Approved 130018-77-8 1549000
28
Serine Approved, Nutraceutical 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria Completed NCT01940393 Phase 4 Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2 Bilastine Updosing in Chronic Spontaneous Urticaria Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
3 Urticaria Facticia Treatment With Omalizumab (UFO) Completed NCT02169115 Phase 2 Omalizumab;Omalizumab;Placebo
4 Cold Urticaria Treatment With Xolair Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
5 Cold Contact Urticaria Treatment With Rilonacept Completed NCT02171416 Phase 2 Rilonacept;Placebo
6 Phase II Solar Urticaria (SU) Pilot Study Completed NCT00859534 Phase 2 afamelanotide
7 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939
8 Electroacupuncture Frequency-related Effects on Non-specific Low Back Pain in Older Adults. Recruiting NCT03802045 Not Applicable
9 Biomarkers for the Detection of Lymphatic Insufficiency Enrolling by invitation NCT02375165
10 The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism Terminated NCT01008592 levocetirizine or placebo

Search NIH Clinical Center for Physical Urticaria

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Genetic Tests for Physical Urticaria

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Anatomical Context for Physical Urticaria

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MalaCards organs/tissues related to Physical Urticaria:

42
Skin, Testes
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Publications for Physical Urticaria

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Articles related to Physical Urticaria:

(show all 50)
# Title Authors Year
1
Epidemiology of urticaria including physical urticaria and angioedema in Korea. ( 29742892 )
2019
2
Food-dependent cold urticaria: A new variant of physical urticaria. ( 29698807 )
2018
3
Physical urticaria. ( 28433981 )
2017
4
Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. ( 28389391 )
2017
5
Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. ( 28951710 )
2017
6
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. ( 27585061 )
2016
7
Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. ( 25959894 )
2015
8
Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. ( 26012951 )
2015
9
Symptomatic dermographism: an inadequately described disease. ( 25174372 )
2015
10
Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. ( 25522055 )
2015
11
Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. ( 26677310 )
2015
12
Symptomatic dermographism mimicking latex allergy. ( 24603512 )
2014
13
Dissociation between history and challenge in patients with physical urticaria. ( 25439372 )
2014
14
Contemporary approaches to the diagnosis and management of physical urticaria. ( 24054356 )
2013
15
A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. ( 23621090 )
2013
16
Physical urticaria. ( 22653630 )
2012
17
Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. ( 20733327 )
2011
18
Physical urticaria: prevalence, type and natural course in a tropical country. ( 21175877 )
2011
19
Periorbital physical urticaria in an anophthalmic patient with dermatographism. ( 21217333 )
2011
20
Use of a ballpoint pen in the diagnosis of physical urticaria. ( 21572812 )
2011
21
Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report. ( 19830184 )
2009
22
Clinical features and natural history of physical urticaria in children. ( 18167159 )
2008
23
Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( 18774200 )
2008
24
Evaluation of patients with symptomatic dermographism. ( 16405609 )
2006
25
Physical urticaria. ( 15120149 )
2004
26
A comprehensive review of physical urticaria. ( 12506491 )
2002
27
Pathomechanisms in physical urticaria. ( 11764299 )
2001
28
Congenital symptomatic dermographism as the first symptom of mastocytosis. ( 11069538 )
2000
29
Physical urticaria: classification and diagnostic guidelines. An EAACI position paper. ( 9201361 )
1997
30
Dyspareunia and vulvodynia: unrecognised manifestations of symptomatic dermographism. ( 8988122 )
1997
31
Physical urticaria: a common misdiagnosis. ( 8933536 )
1996
32
Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study. ( 2570004 )
1989
33
Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid. ( 2597634 )
1989
34
The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism. ( 2680176 )
1989
35
Evaluation of three skin tests in physical urticaria. ( 3145842 )
1988
36
Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. ( 3072223 )
1988
37
Symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. ( 3620341 )
1987
38
Physical urticaria. ( 4092383 )
1985
39
Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. ( 6139191 )
1983
40
Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin. ( 7022724 )
1981
41
Symptomatic dermographism. ( 6118390 )
1981
42
Physical urticaria/angioedema: an experimental model of mast cell activation in humans. ( 7002977 )
1980
43
The effect of H1 and H2 histamine antagonists on symptomatic dermographism. ( 475988 )
1979
44
Neuropsychic factors in physical urticaria. ( 844637 )
1977
45
Physical urticaria and sport. ( 891255 )
1977
46
Study of cutaneous mast cells in patients of physical urticaria. ( 4448517 )
1974
47
Physical urticaria. Its diagnosis and treatment. ( 4150683 )
1973
48
Thermo-stimulator a Device To Investigate Cases of Physical Urticaria. ( 29176157 )
1969
49
How I treat physical urticaria. ( 6045898 )
1967
50
Reflexions on the mechanism of physical urticaria (excluding sensitivity to light. ( 13594034 )
1958
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Variations for Physical Urticaria

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Expression for Physical Urticaria

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Search GEO for disease gene expression data for Physical Urticaria.
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Pathways for Physical Urticaria

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Pathways related to Physical Urticaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Sphingolipid signaling pathway 38
10.7 FCER1A MS4A2
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GO Terms for Physical Urticaria

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Cellular components related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 ADGRE2 CCR6 FCER1A MS4A2 TRPV3

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Fc-epsilon receptor signaling pathway GO:0038095 8.96 FCER1A MS4A2
2 inflammatory response GO:0006954 8.8 ADGRE2 MS4A2 SERPINA3

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgE binding GO:0019863 8.62 FCER1A MS4A2
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Sources for Physical Urticaria

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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