Physical Urticaria disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PHY008 MIFTS: 30	Physical Urticaria Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Physical Urticaria

MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria ¹² ⁷⁷ ¹⁵ ¹⁷

Symptomatic Dermographism ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060220

EFO ¹⁷ EFO_1000754

UMLS ⁷⁴ C0343065

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Summaries for Physical Urticaria

Disease Ontology : ¹² An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to cholinergic urticaria and urticaria, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Physical Urticaria is ADGRE2 (Adhesion G Protein-Coupled Receptor E2), and among its related pathways/superpathways is Sphingolipid signaling pathway. The drugs Fexofenadine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Wikipedia : ⁷⁷ Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

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Related Diseases for Physical Urticaria

Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	cholinergic urticaria	31.5	MS4A2 RAX2
2	urticaria	30.7	ADGRE2 FCER1A
3	urticaria, aquagenic	11.2
4	solar urticaria	11.0
5	angioedema	10.1
6	cold urticaria	9.8
7	dermatographia	9.4	CDSN FCER1A MS4A2

Graphical network of the top 20 diseases related to Physical Urticaria:

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Symptoms & Phenotypes for Physical Urticaria

UMLS symptoms related to Physical Urticaria:

integumentary system signs and symptoms, darier's sign

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Drugs & Therapeutics for Physical Urticaria

Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fexofenadine

Approved, Investigational

Phase 4

83799-24-0

3348

Cetirizine

Approved

Phase 4

83881-51-0

2678

Ebastine

Approved, Investigational

Phase 4

90729-43-4

3191

Desloratadine

Approved, Investigational

Phase 4

100643-71-8

124087

Histamine

Approved, Investigational

Phase 4

51-45-6

774

Histamine Phosphate

Phase 4

51-74-1

65513

Anti-Allergic Agents

Phase 4,Phase 2

Cholinergic Agents

Phase 4

Cholinergic Antagonists

Phase 4

Neurotransmitter Agents

Phase 4

Histamine H1 Antagonists

Phase 4,Phase 2

Histamine H1 Antagonists, Non-Sedating

Phase 4

Histamine Antagonists

Phase 4,Phase 2

Omalizumab

Approved, Investigational

Phase 2

242138-07-4

Rilonacept

Approved, Investigational

Phase 2

501081-76-1

104924

Afamelanotide

Experimental, Investigational

Phase 2

75921-69-6

Respiratory System Agents

Phase 2

Antibodies

Phase 2

Immunologic Factors

Phase 2

Antibodies, Monoclonal

Phase 2

Anti-Asthmatic Agents

Phase 2

Immunoglobulins

Phase 2

Anti-Inflammatory Agents

Phase 2

Dermatologic Agents

Phase 2

Levocetirizine

Approved

130018-77-8

1549000

Dinoprostone

Approved

363-24-6

5280360

Ethanol

Approved

Not Applicable

64-17-5

702

Serine

Approved, Nutraceutical

56-45-1

5951

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria	Completed	NCT01940393	Phase 4	Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2	Bilastine Updosing in Chronic Spontaneous Urticaria	Completed	NCT02213367	Phase 3	Bilastine;Bilastine;Bilastin
3	Urticaria Facticia Treatment With Omalizumab (UFO)	Completed	NCT02169115	Phase 2	Omalizumab;Omalizumab;Placebo
4	Cold Urticaria Treatment With Xolair	Completed	NCT01580592	Phase 2	Omalizumab;Omalizumab;Placebo
5	Cold Contact Urticaria Treatment With Rilonacept	Completed	NCT02171416	Phase 2	Rilonacept;Placebo
6	Phase II Solar Urticaria (SU) Pilot Study	Completed	NCT00859534	Phase 2	afamelanotide
7	The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism	Terminated	NCT01008592		levocetirizine or placebo
8	Pathogenesis of Physical Induced Urticarial Syndromes	Recruiting	NCT00887939
9	Electroacupuncture Frequency-related Effects on Non-specific Low Back Pain in Older Adults.	Recruiting	NCT03802045	Not Applicable

Search NIH Clinical Center for Physical Urticaria

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Genetic Tests for Physical Urticaria

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Anatomical Context for Physical Urticaria

MalaCards organs/tissues related to Physical Urticaria:

⁴²

Skin, Testes

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Publications for Physical Urticaria

Articles related to Physical Urticaria:

(show all 49)

#	Title	Authors	Year
1	Food-dependent cold urticaria: A new variant of physical urticaria. ( 29698807 )	Kulthanan K....Maurer M.	2018
2	Epidemiology of urticaria including physical urticaria and angioedema in Korea. ( 29742892 )	Seo J.H....Kwon J.W.	2018
3	Physical urticaria. ( 28433981 )	English J....Bajaj K.	2017
4	Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. ( 28389391 )	Maurer M...Metz M	2017
5	Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. ( 28951710 )	Erpolat S...Bozkurt B	2017
6	Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. ( 27585061 )	Cuervo-Pardo L....Lang D.M.	2016
7	Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. ( 26012951 )	Netchiporouk E....Ben-Shoshan M.	2015
8	Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. ( 25959894 )	Trevisonno J....Ben-Shoshan M.	2015
9	Symptomatic dermographism: an inadequately described disease. ( 25174372 )	Schoepke N...Maurer M	2015
10	Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. ( 25522055 )	Schoepke N...Magerl M	2015
11	Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. ( 26677310 )	Mehta A...Patil S	2015
12	Dissociation between history and challenge in patients with physical urticaria. ( 25439372 )	Komarow H.D....Metcalfe D.D.	2014
13	Contemporary approaches to the diagnosis and management of physical urticaria. ( 24054356 )	Lang D.M....Bernstein J.A.	2013
14	A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. ( 23621090 )	Mlynek A...Maurer M	2013
15	Physical urticaria. ( 22653630 )	Abajian M....Maurer M.	2012
16	Periorbital physical urticaria in an anophthalmic patient with dermatographism. ( 21217333 )	Gupta S....Ahmad A.Z.	2011
17	Use of a ballpoint pen in the diagnosis of physical urticaria. ( 21572812 )	Godse K.V.	2011
18	Physical urticaria: prevalence, type and natural course in a tropical country. ( 21175877 )	Silpa-archa N....Pinkaew S.	2011
19	Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. ( 20733327 )	Metz M....Maurer M.	2011
20	Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report. ( 19830184 )	Rahim KF...Dawe RS	2009
21	Clinical features and natural history of physical urticaria in children. ( 18167159 )	Khakoo G....Lack G.	2008
22	Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( 18774200 )	Borzova E...Grattan CE	2008
23	Evaluation of patients with symptomatic dermographism. ( 16405609 )	Ta?kapan O...Harmanyeri Y	2006
24	Physical urticaria. ( 15120149 )	Dice J.P.	2004
25	A comprehensive review of physical urticaria. ( 12506491 )	Muller B.A.	2002
26	Pathomechanisms in physical urticaria. ( 11764299 )	Grabbe J.	2001
27	Congenital symptomatic dermographism as the first symptom of mastocytosis. ( 11069538 )	Grimm V...Abeck D	2000
28	Physical urticaria: classification and diagnostic guidelines. An EAACI position paper. ( 9201361 )	Kontou-Fili K....Mitchel F.B.	1997
29	Dyspareunia and vulvodynia: unrecognised manifestations of symptomatic dermographism. ( 8988122 )	Lambiris A...Greaves MW	1997
30	Physical urticaria: a common misdiagnosis. ( 8933536 )	Scott C.B....Moloney M.F.	1996
31	Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study. ( 2570004 )	Boyle J...Gibson JR	1989
32	Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid. ( 2597634 )	Lawlor F...Greaves MW	1989
33	The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism. ( 2680176 )	Logan RA...Greaves MW	1989
34	Evaluation of three skin tests in physical urticaria. ( 3145842 )	Zhu T.C.	1988
35	Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. ( 3072223 )	Lawlor F...Greaves MW	1988
36	Symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. ( 3620341 )	Murphy GM...Winkelmann RK	1987
37	Physical urticaria. ( 4092383 )	Sibbald R.G.	1985
38	Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. ( 6139191 )	Breathnach SM...Greaves MW	1983
39	Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin. ( 7022724 )	Soter N.A.	1981
40	Symptomatic dermographism. ( 6118390 )	Margolis CF...Estes SA	1981
41	Physical urticaria/angioedema: an experimental model of mast cell activation in humans. ( 7002977 )	Soter N.A....Wasserman S.I.	1980
42	The effect of H1 and H2 histamine antagonists on symptomatic dermographism. ( 475988 )	Matthews CN...Storari F	1979
43	Physical urticaria and sport. ( 891255 )	Mikhailov P....Andreev V.C.	1977
44	Neuropsychic factors in physical urticaria. ( 844637 )	Czubalski K...Rudzki E	1977
45	Study of cutaneous mast cells in patients of physical urticaria. ( 4448517 )	Pasricha JS...Kandhari KC	1974
46	Physical urticaria. Its diagnosis and treatment. ( 4150683 )	Illig L	1973
47	Thermo-stimulator a Device To Investigate Cases of Physical Urticaria. ( 29176157 )	Pasricha JS...Malhotra YK	1969
48	How I treat physical urticaria. ( 6045898 )	Shapiro AL	1967
49	Reflexions on the mechanism of physical urticaria (excluding sensitivity to light. ( 13594034 )	RAJKA G	1958

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Genes for Physical Urticaria

Genes related to Physical Urticaria (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ADGRE2	Adhesion G Protein-Coupled Receptor E2	Protein Coding	17.64	DISEASES inferred ¹⁵
2	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	17.11	DISEASES inferred ¹⁵ ¹⁵
3	SERPINA3	Serpin Family A Member 3	Protein Coding	16.73	DISEASES inferred ¹⁵ ¹⁵
4	RAX2	Retina And Anterior Neural Fold Homeobox 2	Protein Coding	16.27	DISEASES inferred ¹⁵
5	FCER1A	Fc Fragment Of IgE Receptor Ia	Protein Coding	15.28	DISEASES inferred ¹⁵
6	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	15.28	DISEASES inferred ¹⁵
7	TRPV3	Transient Receptor Potential Cation Channel Subfamily V Member 3	Protein Coding	14.83	DISEASES inferred ¹⁵
8	CDSN	Corneodesmosin	Protein Coding	14.82	DISEASES inferred ¹⁵

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Variations for Physical Urticaria

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Expression for Physical Urticaria

Search GEO for disease gene expression data for Physical Urticaria.

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Pathways for Physical Urticaria

Pathways related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Sphingolipid signaling pathway ³⁸	10.7	FCER1A MS4A2

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GO Terms for Physical Urticaria

Cellular components related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.02	ADGRE2 CCR6 FCER1A MS4A2 TRPV3

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Fc-epsilon receptor signaling pathway	GO:0038095	8.96	FCER1A MS4A2
2	inflammatory response	GO:0006954	8.8	ADGRE2 MS4A2 SERPINA3

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	IgE binding	GO:0019863	8.62	FCER1A MS4A2

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Sources for Physical Urticaria

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia