Aliases & Classifications for Physical Urticaria

MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria 12 75 15 17
Symptomatic Dermographism 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0060220
UMLS 72 C0343065

Summaries for Physical Urticaria

Disease Ontology : 12 An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to urticaria and dermatographia, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Physical Urticaria is ADGRE2 (Adhesion G Protein-Coupled Receptor E2). The drugs Omalizumab and Rilonacept have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil.

Wikipedia : 75 Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

Related Diseases for Physical Urticaria

Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 urticaria 30.0 SERPING1 FCER1A ADGRE2
2 dermatographia 28.8 FCER1A CDSN
3 urticaria, aquagenic 11.6
4 cholinergic urticaria 11.5
5 solar urticaria 11.5
6 angioedema 10.3
7 cold urticaria 10.2
8 vibratory urticaria 10.0
9 exercise-induced anaphylaxis 10.0
10 ige responsiveness, atopic 9.8
11 mastocytosis 9.8
12 vasculitis 9.8
13 allergic urticaria 9.4 SERPING1 FCER1A

Graphical network of the top 20 diseases related to Physical Urticaria:



Diseases related to Physical Urticaria

Symptoms & Phenotypes for Physical Urticaria

UMLS symptoms related to Physical Urticaria:


integumentary system signs and symptoms, darier's sign

Drugs & Therapeutics for Physical Urticaria

Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2
Rilonacept Approved, Investigational Phase 2 501081-76-1 104924
3
Afamelanotide Experimental, Investigational Phase 2 75921-69-6
4 Anti-Allergic Agents Phase 2
5 Respiratory System Agents Phase 2
6 Antibodies Phase 2
7 Immunologic Factors Phase 2
8 Antibodies, Monoclonal Phase 2
9 Immunoglobulins Phase 2
10 Anti-Asthmatic Agents Phase 2
11 Histamine Antagonists Phase 2
12 Histamine H1 Antagonists Phase 2
13 Neurotransmitter Agents Phase 2
14 Cholinergic Agents Phase 2
15 Vaccines Phase 2
16 Anti-Inflammatory Agents Phase 2
17 Dermatologic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 3 Study, Exploratory, Disease Activity Controlled Dose Escalating Study to Assess the Efficacy, and Safety of Treatment With Bilastine 20 mg, 40 mg and 80 mg in Chronic Spontaneous Urticaria. Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
2 Double-blind, Placebo-controlled 12-week, Parallel-group Study With a 6 Weeks Follow up Period to Demonstrate Efficacy and Safety of Subcutaneous Omalizumab in Patients With Urticaria Factitia Refractory to Standard Treatment Completed NCT02169115 Phase 2 Omalizumab;Omalizumab;Placebo
3 A Two-center, Double Blind, Placebo-controlled Study in Parallel Design to Assess the Efficacy and Safety of 150 and 300 mg Omalizumab in Subjects With Antihistamine-resistant Cold Contact Urticaria (CCU) Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
4 Multicenter Randomized, Double-blind, Placebo-controlled Parallel Clinical Trial to Assess Efficacy and Safety of Omalizumab (Xolair®) in a New Indication: Cholinergic Urticarial Completed NCT02012387 Phase 2
5 A Single-center, Double-blind Placebo-controlled Parallel Group Phase II Study of the Efficacy and Safety of Rilonacept in Subjects With Cold Contact Urticaria (CCU) Completed NCT02171416 Phase 2 Rilonacept;Placebo
6 A Phase II, Open Label Pilot Study to Evaluate the Safety and Efficacy of A Bioresorbable Subcutaneous Implant of CUV1647 in Patients With Solar Urticaria (SU) Completed NCT00859534 Phase 2 afamelanotide
7 Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Physical Urticaria

Genetic Tests for Physical Urticaria

Anatomical Context for Physical Urticaria

MalaCards organs/tissues related to Physical Urticaria:

41
Skin, Testes, Neutrophil

Publications for Physical Urticaria

Articles related to Physical Urticaria:

(show top 50) (show all 254)
# Title Authors PMID Year
1
Management problems in severe chronic inducible urticaria: Two case reports. 38
31384330 2019
2
Incapacitating solar urticaria: successful treatment with omalizumab. 38
31365663 2019
3
Benefit of benralizumab treatment in a patient with chronic symptomatic dermographism. 38
31140658 2019
4
Natural course and prognostic factors of chronic urticaria in Korean children: A single center experience. 38
29888927 2019
5
Epidemiology of urticaria including physical urticaria and angioedema in Korea. 38
29742892 2019
6
Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index. 38
30286461 2019
7
Anaphylaxis in atypical cold urticaria: case report and review of literature. 38
30424814 2018
8
Post-infectious sensory neuropathy with anti-GT1a and GQ1b antibodies associated with cold urticaria. 38
30318072 2018
9
How to Approach Chronic Inducible Urticaria. 38
30033913 2018
10
Food-dependent cold urticaria: A new variant of physical urticaria. 38
29698807 2018
11
Chronic inducible urticaria: A systematic review of treatment options. 38
29438771 2018
12
Pattern of chronic urticaria and value of autologous serum skin test in Sohag Province, Upper Egypt. 38
29997762 2018
13
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 38
28751232 2018
14
Local heat urticaria. 38
29447656 2017
15
Aquagenic Urticaria: A Perplexing Physical Phenomenon. 38
29252177 2017
16
Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. 38
28389391 2017
17
Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. 38
28951710 2017
18
Review of Physical Urticarias and Testing Methods. 38
28634900 2017
19
Aquagenic Urticaria Diagnosed by the Water Provocation Test and the Results of Histopathologic Examination. 38
28566914 2017
20
Localized Heat Urticaria from 95-GHz Millimeter Waves. 38
28539148 2017
21
Obstructive sleep apnea and dermatologic disorders. 38
28511831 2017
22
Physical urticaria. 38
28433981 2017
23
Therapy of antihistamine-resistant chronic spontaneous urticaria. 38
27744711 2017
24
Basophil CD63 expression in chronic spontaneous urticaria: correlation with allergic sensitization, serum autoreactivity and basophil reactivity. 38
27518369 2017
25
Prevalence of Inducible Urticaria in Patients with Chronic Spontaneous Urticaria: Associated Risk Factors. 38
27838325 2017
26
Cold-induced Anaphylaxis: The Case of a 9-year-old Child and Review of the Literature. 38
28675997 2017
27
Impact of chronic urticaria on the quality of life of patients followed up at a university hospital. 38
28099596 2016
28
Vibrational angioedema: considerations for oral health care providers. 38
27114270 2016
29
Clinical and etiologic evaluation of the children with chronic urticaria. 38
27931300 2016
30
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. 38
27585061 2016
31
A prospective ten-year follow-up of patients with chronic urticaria. 38
27083494 2016
32
Dermographism in the Oral Cavity. 38
27324161 2016
33
Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity. 38
26619922 2016
34
Positive CD63 Basophil Activation Tests Are Common in Children with Chronic Spontaneous Urticaria and Linked to High Disease Activity. 38
27846634 2016
35
Diagnosis and management of cold urticaria. 38
26919357 2016
36
Aquagenic urticaria: diagnostic and management challenges. 38
27942227 2016
37
Advances in Understanding and Managing Chronic Urticaria. 38
26949520 2016
38
[Localized salt-dependent aquagenic urticaria: A case report]. 38
26610359 2015
39
Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. 38
26677310 2015
40
An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria. 38
25266078 2015
41
Snoring-Induced Vibratory Angioedema. 38
26437464 2015
42
Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. 38
26012951 2015
43
Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. 38
25959894 2015
44
Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria. 38
26225328 2015
45
Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. 38
25522055 2015
46
Refractory case of adrenergic urticaria successfully treated with clotiazepam. 38
25810001 2015
47
Investigation of patient-specific characteristics associated with treatment outcomes for chronic urticaria. 38
25680926 2015
48
Symptomatic dermographism: an inadequately described disease. 38
25174372 2015
49
Activation of coagulation in chronic urticaria in relation to disease severity and activity. 38
25088671 2015
50
Temperature thresholds in assessment of the clinical course of acquired cold contact urticaria: a prospective observational one-year study. 38
24977664 2015

Variations for Physical Urticaria

Expression for Physical Urticaria

Search GEO for disease gene expression data for Physical Urticaria.

Pathways for Physical Urticaria

GO Terms for Physical Urticaria

Cellular components related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.26 TRPV3 FCER1A CCR6 ADGRE2
2 blood microparticle GO:0072562 9.16 SERPING1 SERPINA3
3 platelet alpha granule lumen GO:0031093 8.62 SERPING1 SERPINA3

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 9.16 SERPING1 SERPINA3
2 platelet degranulation GO:0002576 8.96 SERPING1 SERPINA3
3 negative regulation of peptidase activity GO:0010466 8.62 SERPING1 SERPINA3

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 8.96 SERPING1 SERPINA3
2 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPING1 SERPINA3

Sources for Physical Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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