Aliases & Classifications for Physical Urticaria

MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria 12 76 15
Symptomatic Dermographism 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060220
UMLS 73 C0343065

Summaries for Physical Urticaria

Disease Ontology : 12 An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to cholinergic urticaria and urticaria, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Physical Urticaria is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Sphingolipid signaling pathway and TRP channels. The drugs Desloratadine and Ebastine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Wikipedia : 76 Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

Related Diseases for Physical Urticaria

Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 cholinergic urticaria 32.0 MS4A2 RAX2
2 urticaria 30.8 ADGRE2 FCER1A
3 urticaria, aquagenic 11.2
4 solar urticaria 11.0
5 angioedema 10.1
6 dentin sensitivity 10.0 TRPV1 TRPV3
7 nasal cavity disease 10.0 MS4A2 TRPV1
8 nose disease 10.0 MS4A2 TRPV1
9 upper respiratory tract disease 10.0 MS4A2 TRPV1
10 bronchial disease 10.0 MS4A2 TRPV1
11 immune system disease 9.9 MS4A2 TRPV1
12 respiratory system disease 9.8 MS4A2 TRPV1
13 cold urticaria 9.8
14 dermatographia 9.6 FCER1A MS4A2 OSMR

Graphical network of the top 20 diseases related to Physical Urticaria:



Diseases related to Physical Urticaria

Symptoms & Phenotypes for Physical Urticaria

UMLS symptoms related to Physical Urticaria:


integumentary system signs and symptoms, darier's sign

Drugs & Therapeutics for Physical Urticaria

Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
2
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
3
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
4
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
5
Cetirizine Approved Phase 4 83881-51-0 2678
6 Histamine H1 Antagonists, Non-Sedating Phase 4
7 Cholinergic Antagonists Phase 4
8 Anti-Allergic Agents Phase 4,Phase 2
9 Cholinergic Agents Phase 4
10 Neurotransmitter Agents Phase 4
11 Histamine H1 Antagonists Phase 4,Phase 2
12
Histamine Phosphate Phase 4 51-74-1 65513
13 Histamine Antagonists Phase 4,Phase 2
14
Omalizumab Approved, Investigational Phase 2 242138-07-4
15 Anti-Asthmatic Agents Phase 2
16 Immunologic Factors Phase 2
17 Antibodies, Monoclonal Phase 2
18 Antibodies Phase 2
19 Respiratory System Agents Phase 2
20 Immunoglobulins Phase 2
21
Levocetirizine Approved 130018-77-8 1549000
22
Dinoprostone Approved 363-24-6 5280360
23
Serine Approved, Nutraceutical 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria Completed NCT01940393 Phase 4 Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2 Bilastine Updosing in Chronic Spontaneous Urticaria Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
3 Urticaria Facticia Treatment With Omalizumab (UFO) Completed NCT02169115 Phase 2 Omalizumab;Omalizumab;Placebo
4 Cold Urticaria Treatment With Xolair Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
5 Cold Contact Urticaria Treatment With Rilonacept Completed NCT02171416 Phase 2 Rilonacept;Placebo
6 Phase II Solar Urticaria (SU) Pilot Study Completed NCT00859534 Phase 2 afamelanotide
7 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939
8 Electroacupuncture Frequency-related Effects on Non-specific Low Back Pain in Older Adults. Recruiting NCT03802045 Not Applicable
9 The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism Terminated NCT01008592 levocetirizine or placebo

Search NIH Clinical Center for Physical Urticaria

Genetic Tests for Physical Urticaria

Anatomical Context for Physical Urticaria

MalaCards organs/tissues related to Physical Urticaria:

41
Skin, Testes

Publications for Physical Urticaria

Articles related to Physical Urticaria:

(show all 49)
# Title Authors Year
1
Food-dependent cold urticaria: A new variant of physical urticaria. ( 29698807 )
2018
2
Epidemiology of urticaria including physical urticaria and angioedema in Korea. ( 29742892 )
2018
3
Physical urticaria. ( 28433981 )
2017
4
Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. ( 28389391 )
2017
5
Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. ( 28951710 )
2017
6
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. ( 27585061 )
2016
7
Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. ( 26012951 )
2015
8
Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. ( 25959894 )
2015
9
Symptomatic dermographism: an inadequately described disease. ( 25174372 )
2015
10
Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. ( 25522055 )
2015
11
Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. ( 26677310 )
2015
12
Dissociation between history and challenge in patients with physical urticaria. ( 25439372 )
2014
13
Contemporary approaches to the diagnosis and management of physical urticaria. ( 24054356 )
2013
14
A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. ( 23621090 )
2013
15
Physical urticaria. ( 22653630 )
2012
16
Periorbital physical urticaria in an anophthalmic patient with dermatographism. ( 21217333 )
2011
17
Use of a ballpoint pen in the diagnosis of physical urticaria. ( 21572812 )
2011
18
Physical urticaria: prevalence, type and natural course in a tropical country. ( 21175877 )
2011
19
Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. ( 20733327 )
2011
20
Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report. ( 19830184 )
2009
21
Clinical features and natural history of physical urticaria in children. ( 18167159 )
2008
22
Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( 18774200 )
2008
23
Evaluation of patients with symptomatic dermographism. ( 16405609 )
2006
24
Physical urticaria. ( 15120149 )
2004
25
A comprehensive review of physical urticaria. ( 12506491 )
2002
26
Pathomechanisms in physical urticaria. ( 11764299 )
2001
27
Congenital symptomatic dermographism as the first symptom of mastocytosis. ( 11069538 )
2000
28
Physical urticaria: classification and diagnostic guidelines. An EAACI position paper. ( 9201361 )
1997
29
Dyspareunia and vulvodynia: unrecognised manifestations of symptomatic dermographism. ( 8988122 )
1997
30
Physical urticaria: a common misdiagnosis. ( 8933536 )
1996
31
Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study. ( 2570004 )
1989
32
Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid. ( 2597634 )
1989
33
The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism. ( 2680176 )
1989
34
Evaluation of three skin tests in physical urticaria. ( 3145842 )
1988
35
Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. ( 3072223 )
1988
36
Symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. ( 3620341 )
1987
37
Physical urticaria. ( 4092383 )
1985
38
Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. ( 6139191 )
1983
39
Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin. ( 7022724 )
1981
40
Symptomatic dermographism. ( 6118390 )
1981
41
Physical urticaria/angioedema: an experimental model of mast cell activation in humans. ( 7002977 )
1980
42
The effect of H1 and H2 histamine antagonists on symptomatic dermographism. ( 475988 )
1979
43
Physical urticaria and sport. ( 891255 )
1977
44
Neuropsychic factors in physical urticaria. ( 844637 )
1977
45
Study of cutaneous mast cells in patients of physical urticaria. ( 4448517 )
1974
46
Physical urticaria. Its diagnosis and treatment. ( 4150683 )
1973
47
Thermo-stimulator a Device To Investigate Cases of Physical Urticaria. ( 29176157 )
1969
48
How I treat physical urticaria. ( 6045898 )
1967
49
Reflexions on the mechanism of physical urticaria (excluding sensitivity to light. ( 13594034 )
1958

Variations for Physical Urticaria

Expression for Physical Urticaria

Search GEO for disease gene expression data for Physical Urticaria.

Pathways for Physical Urticaria

Pathways related to Physical Urticaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 FCER1A MS4A2
2 10.02 TRPV1 TRPV3

GO Terms for Physical Urticaria

Cellular components related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.73 ADGRE2 FCER1A MS4A2 OSMR TRPV1 TRPV3
2 plasma membrane GO:0005886 9.63 ADGRE2 FCER1A MS4A2 OSMR TRPV1 TRPV3
3 external side of plasma membrane GO:0009897 9.13 MS4A2 OSMR TRPV1
4 integral component of plasma membrane GO:0005887 9.02 ADGRE2 FCER1A MS4A2 TRPV1 TRPV3

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion transport GO:0006816 9.37 TRPV1 TRPV3
2 inflammatory response GO:0006954 9.33 ADGRE2 MS4A2 TRPV1
3 calcium ion transmembrane transport GO:0070588 9.32 TRPV1 TRPV3
4 Fc-epsilon receptor signaling pathway GO:0038095 9.26 FCER1A MS4A2
5 response to heat GO:0009408 8.96 TRPV1 TRPV3
6 cell surface receptor signaling pathway GO:0007166 8.8 ADGRE2 MS4A2 TRPV1

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 9.16 TRPV1 TRPV3
2 cation channel activity GO:0005261 8.96 TRPV1 TRPV3
3 IgE binding GO:0019863 8.62 FCER1A MS4A2

Sources for Physical Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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