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MCID: PHY008
MIFTS: 36

Physical Urticaria

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Physical Urticaria

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MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria 12 74 15 17
Symptomatic Dermographism 71

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060220
UMLS 71 C0343065
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Summaries for Physical Urticaria

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Disease Ontology : 12 An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to cholinergic urticaria and angioedema, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Physical Urticaria is ADGRE2 (Adhesion G Protein-Coupled Receptor E2), and among its related pathways/superpathways are NF-kappaB Signaling and GPCRs, Other. The drugs Omalizumab and Rilonacept have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and heart, and related phenotype is renal/urinary system.

Wikipedia : 74 Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

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Related Diseases for Physical Urticaria

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Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 cholinergic urticaria 32.0 SERPING1 SERPINA3 HRH1 ENPP3 CHRM3
2 angioedema 30.2 SERPING1 KNG1 HRH1 CRP
3 cold urticaria 30.2 PLCG2 NLRP3
4 dermatographia 29.0 TPT1 SERPING1 FCER1A CRP CD63
5 vibratory urticaria 28.7 PLCG2 ADGRG1 ADGRE2 ADGRB2
6 urticaria 28.5 TPT1 SERPING1 PLCG2 NLRP3 HRH1 FCER1A
7 urticaria, aquagenic 11.6
8 solar urticaria 11.5
9 blepharochalasis 10.5 SERPING1 SERPINA3
10 amoxicillin allergy 10.4 ENPP3 CD63
11 fruit allergy 10.4 ENPP3 CD63
12 diclofenac allergy 10.4 ENPP3 CD63
13 hydrops, lactic acidosis, and sideroblastic anemia 10.3 SERPING1 KNG1
14 egg allergy 10.3 ENPP3 CD63
15 acquired angioedema 10.3 SERPING1 CRP
16 acute dacryoadenitis 10.3 ENPP3 CRP
17 aplasia of lacrimal and salivary glands 10.3 HRH1 CHRM3
18 aspiration pneumonitis 10.3 SERPINA3 CRP
19 atypical depressive disorder 10.3 SERPINA3 CRP
20 epiglottitis 10.3 SERPING1 CRP
21 heart aneurysm 10.3 SERPINA3 CRP
22 coronary aneurysm 10.3 SERPINA3 CRP
23 nut allergy 10.3 ENPP3 CD63
24 splenic infarction 10.3 SERPINA3 CRP
25 heart cancer 10.2 SERPINA3 CRP
26 polyclonal hypergammaglobulinemia 10.2 SERPINA3 CRP
27 large intestine lipoma 10.2 ENPP3 CRP
28 lipoma of colon 10.2 ENPP3 CRP
29 acute stress disorder 10.2 SERPINA3 CRP
30 c1 inhibitor deficiency 10.2 SERPING1 SERPINA3 KNG1
31 interval angle-closure glaucoma 10.2 KNG1 CRP
32 central nervous system vasculitis 10.2 SERPINA3 CRP
33 ascending cholangitis 10.2 CRP CHRM3
34 ureterolithiasis 10.2 CRP CHRM3
35 hypersensitivity vasculitis 10.2 SERPINA3 CRP
36 bursitis 10.2 KNG1 CRP
37 oxirane allergy 10.2 KNG1 ENPP3 CD63
38 allergic urticaria 10.2 SERPING1 KNG1 FCER1A
39 hypersensitivity reaction type iii disease 10.2 SERPINA3 CRP
40 gas gangrene 10.1 SERPINA3 CRP
41 coronary artery vasospasm 10.1 KNG1 CRP
42 food allergy 10.1 TPT1 HRH1 ENPP3
43 cecal disease 10.1 SERPINA3 CRP
44 cryopyrin-associated periodic syndrome 10.1 NLRP3 CRP
45 renal infectious disease 10.1 NLRP3 CRP
46 optic papillitis 10.1 NLRP3 CRP
47 bronchopneumonia 10.1 SERPINA3 CRP
48 upper respiratory tract disease 10.1 SERPINA3 HRH1 CRP
49 rhinitis 10.1 TPT1 KNG1 HRH1
50 cervical adenitis 10.1 NLRP3 CRP

Graphical network of the top 20 diseases related to Physical Urticaria:



Diseases related to Physical Urticaria
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Symptoms & Phenotypes for Physical Urticaria

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UMLS symptoms related to Physical Urticaria:


integumentary system signs and symptoms, darier's sign

MGI Mouse Phenotypes related to Physical Urticaria:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 ADGRB2 CD63 CHRM3 HRH1 NLRP3 PLCG2
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Drugs & Therapeutics for Physical Urticaria

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Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2
Rilonacept Approved, Investigational Phase 2 501081-76-1 104924
3
Afamelanotide Approved, Investigational Phase 2 75921-69-6
4 Antibodies, Monoclonal Phase 2
5 Respiratory System Agents Phase 2
6 Anti-Asthmatic Agents Phase 2
7 Antibodies Phase 2
8 Immunologic Factors Phase 2
9 Anti-Allergic Agents Phase 2
10 Immunoglobulins Phase 2
11 Histamine H1 Antagonists Phase 2
12 Histamine Antagonists Phase 2
13 Vaccines Phase 2
14 Neurotransmitter Agents Phase 2
15 Cholinergic Agents Phase 2
16 Anti-Inflammatory Agents Phase 2
17 Dermatologic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 3 Study, Exploratory, Disease Activity Controlled Dose Escalating Study to Assess the Efficacy, and Safety of Treatment With Bilastine 20 mg, 40 mg and 80 mg in Chronic Spontaneous Urticaria. Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
2 Double-blind, Placebo-controlled 12-week, Parallel-group Study With a 6 Weeks Follow up Period to Demonstrate Efficacy and Safety of Subcutaneous Omalizumab in Patients With Urticaria Factitia Refractory to Standard Treatment Completed NCT02169115 Phase 2 Omalizumab;Omalizumab;Placebo
3 A Two-center, Double Blind, Placebo-controlled Study in Parallel Design to Assess the Efficacy and Safety of 150 and 300 mg Omalizumab in Subjects With Antihistamine-resistant Cold Contact Urticaria (CCU) Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
4 Multicenter Randomized, Double-blind, Placebo-controlled Parallel Clinical Trial to Assess Efficacy and Safety of Omalizumab (Xolair®) in a New Indication: Cholinergic Urticarial Completed NCT02012387 Phase 2
5 A Single-center, Double-blind Placebo-controlled Parallel Group Phase II Study of the Efficacy and Safety of Rilonacept in Subjects With Cold Contact Urticaria (CCU) Completed NCT02171416 Phase 2 Rilonacept;Placebo
6 A Phase II, Open Label Pilot Study to Evaluate the Safety and Efficacy of A Bioresorbable Subcutaneous Implant of CUV1647 in Patients With Solar Urticaria (SU) Completed NCT00859534 Phase 2 afamelanotide
7 Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Physical Urticaria

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Genetic Tests for Physical Urticaria

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Anatomical Context for Physical Urticaria

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MalaCards organs/tissues related to Physical Urticaria:

40
Skin, Testes, Heart, Neutrophil, Bone, Colon, Salivary Gland
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Publications for Physical Urticaria

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Articles related to Physical Urticaria:

(show top 50) (show all 254)
# Title Authors PMID Year
1
Benefit of benralizumab treatment in a patient with chronic symptomatic dermographism. 61
31140658 2019
2
Management problems in severe chronic inducible urticaria: Two case reports. 61
31384330 2019
3
Incapacitating solar urticaria: successful treatment with omalizumab. 61
31365663 2019
4
Natural course and prognostic factors of chronic urticaria in Korean children: A single center experience. 61
29888927 2019
5
Epidemiology of urticaria including physical urticaria and angioedema in Korea. 61
29742892 2019
6
Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index. 61
30286461 2019
7
Anaphylaxis in atypical cold urticaria: case report and review of literature. 61
30424814 2018
8
Post-infectious sensory neuropathy with anti-GT1a and GQ1b antibodies associated with cold urticaria. 61
30318072 2018
9
How to Approach Chronic Inducible Urticaria. 61
30033913 2018
10
Food-dependent cold urticaria: A new variant of physical urticaria. 61
29698807 2018
11
Chronic inducible urticaria: A systematic review of treatment options. 61
29438771 2018
12
Pattern of chronic urticaria and value of autologous serum skin test in Sohag Province, Upper Egypt. 61
29997762 2018
13
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 61
28751232 2018
14
Local heat urticaria. 61
29447656 2017
15
Aquagenic Urticaria: A Perplexing Physical Phenomenon. 61
29252177 2017
16
Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. 61
28389391 2017
17
Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. 61
28951710 2017
18
Review of Physical Urticarias and Testing Methods. 61
28634900 2017
19
Localized Heat Urticaria from 95-GHz Millimeter Waves. 61
28539148 2017
20
Aquagenic Urticaria Diagnosed by the Water Provocation Test and the Results of Histopathologic Examination. 61
28566914 2017
21
Obstructive sleep apnea and dermatologic disorders. 61
28511831 2017
22
Physical urticaria. 61
28433981 2017
23
Therapy of antihistamine-resistant chronic spontaneous urticaria. 61
27744711 2017
24
Basophil CD63 expression in chronic spontaneous urticaria: correlation with allergic sensitization, serum autoreactivity and basophil reactivity. 61
27518369 2017
25
Prevalence of Inducible Urticaria in Patients with Chronic Spontaneous Urticaria: Associated Risk Factors. 61
27838325 2017
26
Cold-induced Anaphylaxis: The Case of a 9-year-old Child and Review of the Literature. 61
28675997 2017
27
Impact of chronic urticaria on the quality of life of patients followed up at a university hospital. 61
28099596 2016
28
Vibrational angioedema: considerations for oral health care providers. 61
27114270 2016
29
Clinical and etiologic evaluation of the children with chronic urticaria. 61
27931300 2016
30
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. 61
27585061 2016
31
A prospective ten-year follow-up of patients with chronic urticaria. 61
27083494 2016
32
Dermographism in the Oral Cavity. 61
27324161 2016
33
Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity. 61
26619922 2016
34
Positive CD63 Basophil Activation Tests Are Common in Children with Chronic Spontaneous Urticaria and Linked to High Disease Activity. 61
27846634 2016
35
Diagnosis and management of cold urticaria. 61
26919357 2016
36
Aquagenic urticaria: diagnostic and management challenges. 61
27942227 2016
37
Advances in Understanding and Managing Chronic Urticaria. 61
26949520 2016
38
[Localized salt-dependent aquagenic urticaria: A case report]. 61
26610359 2015
39
Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. 61
26677310 2015
40
An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria. 61
25266078 2015
41
Snoring-Induced Vibratory Angioedema. 61
26437464 2015
42
Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. 61
26012951 2015
43
Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. 61
25959894 2015
44
Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria. 61
26225328 2015
45
Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. 61
25522055 2015
46
Refractory case of adrenergic urticaria successfully treated with clotiazepam. 61
25810001 2015
47
Investigation of patient-specific characteristics associated with treatment outcomes for chronic urticaria. 61
25680926 2015
48
Symptomatic dermographism: an inadequately described disease. 61
25174372 2015
49
Activation of coagulation in chronic urticaria in relation to disease severity and activity. 61
25088671 2015
50
Temperature thresholds in assessment of the clinical course of acquired cold contact urticaria: a prospective observational one-year study. 61
24977664 2015
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Variations for Physical Urticaria

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Expression for Physical Urticaria

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Search GEO for disease gene expression data for Physical Urticaria.
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Pathways for Physical Urticaria

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Pathways related to Physical Urticaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.77 TPT1 PLCG2 ENPP3 CD63
2
GPCRs, Other 1
10.81 CHRM3 ADGRG1 ADGRE2
3
IL1 and megakaryocytes in obesity 1
10.55 NLRP3 FCER1A
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GO Terms for Physical Urticaria

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Cellular components related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 PLCG2 KNG1 HRH1 FCER1A ENPP3 CHRM3
2 extracellular region GO:0005576 9.86 SERPING1 SERPINA3 NLRP3 KNG1 ENPP3 CRP
3 extracellular exosome GO:0070062 9.76 TPT1 SERPING1 SERPINA3 PLCG2 KNG1 ENPP3
4 blood microparticle GO:0072562 9.5 SERPING1 SERPINA3 KNG1
5 integral component of plasma membrane GO:0005887 9.17 HRH1 FCER1A CHRM3 CD63 ADGRG1 ADGRE2
6 platelet alpha granule lumen GO:0031093 9.13 SERPING1 SERPINA3 KNG1

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.95 PLCG2 NLRP3 HRH1 CHRM3 ADGRG1 ADGRE2
2 G protein-coupled receptor signaling pathway GO:0007186 9.73 KNG1 HRH1 CHRM3 ADGRG1 ADGRE2 ADGRB2
3 negative regulation of endopeptidase activity GO:0010951 9.63 SERPING1 SERPINA3 KNG1
4 negative regulation of peptidase activity GO:0010466 9.54 SERPING1 SERPINA3 KNG1
5 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.48 HRH1 CHRM3
6 positive regulation of receptor internalization GO:0002092 9.43 PLCG2 CD63
7 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.33 ADGRG1 ADGRE2 ADGRB2
8 blood coagulation, intrinsic pathway GO:0007597 9.32 SERPING1 KNG1
9 platelet degranulation GO:0002576 9.26 SERPING1 SERPINA3 KNG1 CD63
10 inflammatory response GO:0006954 9.1 SERPINA3 NLRP3 KNG1 HRH1 CRP ADGRE2

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.35 HRH1 CHRM3 ADGRG1 ADGRE2 ADGRB2
2 phosphatidylinositol phospholipase C activity GO:0004435 9.16 PLCG2 CHRM3
3 peptidase inhibitor activity GO:0030414 8.8 SERPING1 SERPINA3 KNG1
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Sources for Physical Urticaria

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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