Aliases & Classifications for Physical Urticaria

MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria 12 76 15
Symptomatic Dermographism 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060220

Summaries for Physical Urticaria

Disease Ontology : 12 An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to cholinergic urticaria and urticaria, and has symptoms including darier's sign and integumentary system signs and symptoms. An important gene associated with Physical Urticaria is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Sphingolipid signaling pathway and TRP channels. The drugs Cetirizine and Desloratadine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related phenotype is immune system.

Wikipedia : 76 Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

Related Diseases for Physical Urticaria

Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 cholinergic urticaria 31.1 MS4A2 POLK RAX2
2 urticaria 29.9 ADGRE2 FCER1A MS4A2
3 urticaria, aquagenic 11.0
4 solar urticaria 10.9
5 nasal cavity disease 10.1 MS4A2 TRPV1
6 nose disease 10.0 MS4A2 TRPV1
7 upper respiratory tract disease 10.0 MS4A2 TRPV1
8 angioedema 10.0
9 bronchial disease 9.9 MS4A2 TRPV1
10 hypersensitivity reaction disease 9.8 MS4A2 TRPV1
11 dentin sensitivity 9.8 TRPV1 TRPV3
12 cold urticaria 9.7
13 allergic hypersensitivity disease 9.6 FCER1A MS4A2 TRPV1
14 respiratory system disease 9.6 MS4A2 TRPV1
15 dermatographia 9.3 FCER1A MS4A2 OSMR

Graphical network of the top 20 diseases related to Physical Urticaria:



Diseases related to Physical Urticaria

Symptoms & Phenotypes for Physical Urticaria

UMLS symptoms related to Physical Urticaria:


darier's sign, integumentary system signs and symptoms

MGI Mouse Phenotypes related to Physical Urticaria:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 FCER1A MS4A2 OSMR POLK TRPV1 TRPV3

Drugs & Therapeutics for Physical Urticaria

Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetirizine Approved Phase 4 83881-51-0 2678
2
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
3
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
4
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
5
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
6 Anti-Allergic Agents Phase 4,Phase 2
7 Cholinergic Agents Phase 4
8 Cholinergic Antagonists Phase 4
9 Histamine Antagonists Phase 4,Phase 2
10 Histamine H1 Antagonists Phase 4,Phase 2
11 Histamine H1 Antagonists, Non-Sedating Phase 4
12
Histamine Phosphate Phase 4 51-74-1 65513
13 Neurotransmitter Agents Phase 4
14
Omalizumab Approved, Investigational Phase 2 242138-07-4
15 Anti-Asthmatic Agents Phase 2
16 Antibodies Phase 2
17 Antibodies, Monoclonal Phase 2
18 Immunoglobulins Phase 2
19 Respiratory System Agents Phase 2
20
Dinoprostone Approved 363-24-6 5280360
21
Levocetirizine Approved 130018-77-8 1549000
22
Serine Approved, Nutraceutical 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria Completed NCT01940393 Phase 4 Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2 Bilastine Updosing in Chronic Spontaneous Urticaria Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
3 Urticaria Facticia Treatment With Omalizumab (UFO) Completed NCT02169115 Phase 2 Omalizumab;Omalizumab;Placebo
4 Cold Urticaria Treatment With Xolair Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
5 Phase II Solar Urticaria (SU) Pilot Study Completed NCT00859534 Phase 2 afamelanotide
6 Cold Contact Urticaria Treatment With Rilonacept Active, not recruiting NCT02171416 Phase 2 Rilonacept;Placebo
7 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939
8 The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism Terminated NCT01008592 levocetirizine or placebo

Search NIH Clinical Center for Physical Urticaria

Genetic Tests for Physical Urticaria

Anatomical Context for Physical Urticaria

MalaCards organs/tissues related to Physical Urticaria:

41
Skin, Testes

Publications for Physical Urticaria

Articles related to Physical Urticaria:

(show all 25)
# Title Authors Year
1
Food-dependent cold urticaria: A new variant of physical urticaria. ( 29698807 )
2018
2
Epidemiology of urticaria including physical urticaria and angioedema in Korea. ( 29742892 )
2018
3
Physical urticaria. ( 28433981 )
2017
4
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. ( 27585061 )
2016
5
Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. ( 26012951 )
2015
6
Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. ( 25959894 )
2015
7
Physical urticarias and cholinergic urticaria. ( 24262690 )
2014
8
Dissociation between history and challenge in patients with physical urticaria. ( 25439372 )
2014
9
Contemporary approaches to the diagnosis and management of physical urticaria. ( 24054356 )
2013
10
Physical urticaria. ( 22653630 )
2012
11
Periorbital physical urticaria in an anophthalmic patient with dermatographism. ( 21217333 )
2011
12
Use of a ballpoint pen in the diagnosis of physical urticaria. ( 21572812 )
2011
13
Physical urticaria: prevalence, type and natural course in a tropical country. ( 21175877 )
2011
14
Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. ( 20733327 )
2011
15
Clinical features and natural history of physical urticaria in children. ( 18167159 )
2008
16
Physical urticaria. ( 15120149 )
2004
17
A comprehensive review of physical urticaria. ( 12506491 )
2002
18
Pathomechanisms in physical urticaria. ( 11764299 )
2001
19
Physical urticaria: classification and diagnostic guidelines. An EAACI position paper. ( 9201361 )
1997
20
Physical urticaria: a common misdiagnosis. ( 8933536 )
1996
21
Evaluation of three skin tests in physical urticaria. ( 3145842 )
1988
22
Physical urticaria. ( 4092383 )
1985
23
Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin. ( 7022724 )
1981
24
Physical urticaria/angioedema: an experimental model of mast cell activation in humans. ( 7002977 )
1980
25
Physical urticaria and sport. ( 891255 )
1977

Variations for Physical Urticaria

Expression for Physical Urticaria

Search GEO for disease gene expression data for Physical Urticaria.

Pathways for Physical Urticaria

Pathways related to Physical Urticaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 FCER1A MS4A2
2 10.02 TRPV1 TRPV3

GO Terms for Physical Urticaria

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.33 ADGRE2 MS4A2 TRPV1
2 response to heat GO:0009408 8.96 TRPV1 TRPV3
3 cell surface receptor signaling pathway GO:0007166 8.8 ADGRE2 MS4A2 TRPV1

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 9.16 TRPV1 TRPV3
2 cation channel activity GO:0005261 8.96 TRPV1 TRPV3
3 IgE binding GO:0019863 8.62 FCER1A MS4A2

Sources for Physical Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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