Physical Urticaria disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PHY008 MIFTS: 32	Physical Urticaria Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Physical Urticaria

MalaCards integrated aliases for Physical Urticaria:

Name: Physical Urticaria ¹² ⁷⁶ ¹⁵

Symptomatic Dermographism ⁷³

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060220

UMLS ⁷³ C0343065

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Summaries for Physical Urticaria

Disease Ontology : ¹² An urticaria induced by external physical influences.

MalaCards based summary : Physical Urticaria, also known as symptomatic dermographism, is related to cholinergic urticaria and urticaria, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Physical Urticaria is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Sphingolipid signaling pathway and TRP channels. The drugs Desloratadine and Ebastine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Wikipedia : ⁷⁶ Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical... more...

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Related Diseases for Physical Urticaria

Diseases related to Physical Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)

#	Related Disease	Score	Top Affiliating Genes
1	cholinergic urticaria	32.0	MS4A2 RAX2
2	urticaria	30.8	ADGRE2 FCER1A
3	urticaria, aquagenic	11.2
4	solar urticaria	11.0
5	angioedema	10.1
6	dentin sensitivity	10.0	TRPV1 TRPV3
7	nasal cavity disease	10.0	MS4A2 TRPV1
8	nose disease	10.0	MS4A2 TRPV1
9	upper respiratory tract disease	10.0	MS4A2 TRPV1
10	bronchial disease	10.0	MS4A2 TRPV1
11	immune system disease	9.9	MS4A2 TRPV1
12	respiratory system disease	9.8	MS4A2 TRPV1
13	cold urticaria	9.8
14	dermatographia	9.6	FCER1A MS4A2 OSMR

Graphical network of the top 20 diseases related to Physical Urticaria:

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Symptoms & Phenotypes for Physical Urticaria

UMLS symptoms related to Physical Urticaria:

integumentary system signs and symptoms, darier's sign

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Drugs & Therapeutics for Physical Urticaria

Drugs for Physical Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Desloratadine

Approved, Investigational

Phase 4

100643-71-8

124087

Ebastine

Approved, Investigational

Phase 4

90729-43-4

3191

Histamine

Approved, Investigational

Phase 4

51-45-6, 75614-87-8

774

Fexofenadine

Approved, Investigational

Phase 4

83799-24-0

3348

Cetirizine

Approved

Phase 4

83881-51-0

2678

Histamine H1 Antagonists, Non-Sedating

Phase 4

Cholinergic Antagonists

Phase 4

Anti-Allergic Agents

Phase 4,Phase 2

Cholinergic Agents

Phase 4

Neurotransmitter Agents

Phase 4

Histamine H1 Antagonists

Phase 4,Phase 2

Histamine Phosphate

Phase 4

51-74-1

65513

Histamine Antagonists

Phase 4,Phase 2

Omalizumab

Approved, Investigational

Phase 2

242138-07-4

Anti-Asthmatic Agents

Phase 2

Immunologic Factors

Phase 2

Antibodies, Monoclonal

Phase 2

Antibodies

Phase 2

Respiratory System Agents

Phase 2

Immunoglobulins

Phase 2

Levocetirizine

Approved

130018-77-8

1549000

Dinoprostone

Approved

363-24-6

5280360

Serine

Approved, Nutraceutical

56-45-1

5951

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria	Completed	NCT01940393	Phase 4	Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2	Bilastine Updosing in Chronic Spontaneous Urticaria	Completed	NCT02213367	Phase 3	Bilastine;Bilastine;Bilastin
3	Urticaria Facticia Treatment With Omalizumab (UFO)	Completed	NCT02169115	Phase 2	Omalizumab;Omalizumab;Placebo
4	Cold Urticaria Treatment With Xolair	Completed	NCT01580592	Phase 2	Omalizumab;Omalizumab;Placebo
5	Cold Contact Urticaria Treatment With Rilonacept	Completed	NCT02171416	Phase 2	Rilonacept;Placebo
6	Phase II Solar Urticaria (SU) Pilot Study	Completed	NCT00859534	Phase 2	afamelanotide
7	Pathogenesis of Physical Induced Urticarial Syndromes	Recruiting	NCT00887939
8	Electroacupuncture Frequency-related Effects on Non-specific Low Back Pain in Older Adults.	Recruiting	NCT03802045	Not Applicable
9	The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism	Terminated	NCT01008592		levocetirizine or placebo

Search NIH Clinical Center for Physical Urticaria

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Genetic Tests for Physical Urticaria

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Anatomical Context for Physical Urticaria

MalaCards organs/tissues related to Physical Urticaria:

⁴¹

Skin, Testes

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Publications for Physical Urticaria

Articles related to Physical Urticaria:

(show all 49)

#	Title	Authors	Year
1	Food-dependent cold urticaria: A new variant of physical urticaria. ( 29698807 )		2018
2	Epidemiology of urticaria including physical urticaria and angioedema in Korea. ( 29742892 )		2018
3	Physical urticaria. ( 28433981 )		2017
4	Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. ( 28389391 )	Maurer M...Metz M	2017
5	Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. ( 28951710 )	Erpolat S...Bozkurt B	2017
6	Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. ( 27585061 )	Cuervo-Pardo L....Lang D.M.	2016
7	Management of pediatric chronic spontaneous and physical urticaria patients with omalizumab: case series. ( 26012951 )	Netchiporouk E....Ben-Shoshan M.	2015
8	Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. ( 25959894 )		2015
9	Symptomatic dermographism: an inadequately described disease. ( 25174372 )	Schoepke N...Maurer M	2015
10	Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. ( 25522055 )	Schoepke N...Magerl M	2015
11	Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. ( 26677310 )	Mehta A...Patil S	2015
12	Dissociation between history and challenge in patients with physical urticaria. ( 25439372 )		2014
13	Contemporary approaches to the diagnosis and management of physical urticaria. ( 24054356 )		2013
14	A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. ( 23621090 )	Mlynek A...Maurer M	2013
15	Physical urticaria. ( 22653630 )	Abajian M....Maurer M.	2012
16	Periorbital physical urticaria in an anophthalmic patient with dermatographism. ( 21217333 )		2011
17	Use of a ballpoint pen in the diagnosis of physical urticaria. ( 21572812 )		2011
18	Physical urticaria: prevalence, type and natural course in a tropical country. ( 21175877 )		2011
19	Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. ( 20733327 )	Metz M...Maurer M	2011
20	Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report. ( 19830184 )	Rahim KF...Dawe RS	2009
21	Clinical features and natural history of physical urticaria in children. ( 18167159 )	Khakoo G...Lack G	2008
22	Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( 18774200 )	Borzova E...Grattan CE	2008
23	Evaluation of patients with symptomatic dermographism. ( 16405609 )	Ta?kapan O...Harmanyeri Y	2006
24	Physical urticaria. ( 15120149 )	Dice J.P.	2004
25	A comprehensive review of physical urticaria. ( 12506491 )		2002
26	Pathomechanisms in physical urticaria. ( 11764299 )	Grabbe J.	2001
27	Congenital symptomatic dermographism as the first symptom of mastocytosis. ( 11069538 )	Grimm V...Abeck D	2000
28	Physical urticaria: classification and diagnostic guidelines. An EAACI position paper. ( 9201361 )		1997
29	Dyspareunia and vulvodynia: unrecognised manifestations of symptomatic dermographism. ( 8988122 )	Lambiris A...Greaves MW	1997
30	Physical urticaria: a common misdiagnosis. ( 8933536 )	Scott C.B....Moloney M.F.	1996
31	Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study. ( 2570004 )	Boyle J...Gibson JR	1989
32	Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid. ( 2597634 )	Lawlor F...Greaves MW	1989
33	The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism. ( 2680176 )	Logan RA...Greaves MW	1989
34	Evaluation of three skin tests in physical urticaria. ( 3145842 )		1988
35	Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. ( 3072223 )	Lawlor F...Greaves MW	1988
36	Symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. ( 3620341 )	Murphy GM...Winkelmann RK	1987
37	Physical urticaria. ( 4092383 )	Sibbald R.G.	1985
38	Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. ( 6139191 )	Breathnach SM...Greaves MW	1983
39	Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin. ( 7022724 )		1981
40	Symptomatic dermographism. ( 6118390 )	Margolis CF...Estes SA	1981
41	Physical urticaria/angioedema: an experimental model of mast cell activation in humans. ( 7002977 )	Soter N.A....Wasserman S.I.	1980
42	The effect of H1 and H2 histamine antagonists on symptomatic dermographism. ( 475988 )	Matthews CN...Storari F	1979
43	Physical urticaria and sport. ( 891255 )	Mikhailov P....Andreev V.C.	1977
44	Neuropsychic factors in physical urticaria. ( 844637 )	Czubalski K...Rudzki E	1977
45	Study of cutaneous mast cells in patients of physical urticaria. ( 4448517 )	Pasricha JS...Kandhari KC	1974
46	Physical urticaria. Its diagnosis and treatment. ( 4150683 )	Illig L	1973
47	Thermo-stimulator a Device To Investigate Cases of Physical Urticaria. ( 29176157 )	Pasricha JS...Malhotra YK	1969
48	How I treat physical urticaria. ( 6045898 )	Shapiro AL	1967
49	Reflexions on the mechanism of physical urticaria (excluding sensitivity to light. ( 13594034 )	RAJKA G	1958

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Genes for Physical Urticaria

Genes related to Physical Urticaria (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	18.57	DISEASES inferred ¹⁵ ¹⁵
2	ADGRE2	Adhesion G Protein-Coupled Receptor E2	Protein Coding	17.65	DISEASES inferred ¹⁵
3	RAX2	Retina And Anterior Neural Fold Homeobox 2	Protein Coding	16.36	DISEASES inferred ¹⁵
4	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	15.3	DISEASES inferred ¹⁵
5	FCER1A	Fc Fragment Of IgE Receptor Ia	Protein Coding	15.3	DISEASES inferred ¹⁵
6	OSMR	Oncostatin M Receptor	Protein Coding	15.24	DISEASES inferred ¹⁵
7	TRPV3	Transient Receptor Potential Cation Channel Subfamily V Member 3	Protein Coding	14.87	DISEASES inferred ¹⁵

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Variations for Physical Urticaria

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Expression for Physical Urticaria

Search GEO for disease gene expression data for Physical Urticaria.

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Pathways for Physical Urticaria

Pathways related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Sphingolipid signaling pathway ³⁷	11.03	FCER1A MS4A2
2	TRP channels ⁶⁶	10.02	TRPV1 TRPV3

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GO Terms for Physical Urticaria

Cellular components related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of membrane	GO:0016021	9.73	ADGRE2 FCER1A MS4A2 OSMR TRPV1 TRPV3
2	plasma membrane	GO:0005886	9.63	ADGRE2 FCER1A MS4A2 OSMR TRPV1 TRPV3
3	external side of plasma membrane	GO:0009897	9.13	MS4A2 OSMR TRPV1
4	integral component of plasma membrane	GO:0005887	9.02	ADGRE2 FCER1A MS4A2 TRPV1 TRPV3

Biological processes related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium ion transport	GO:0006816	9.37	TRPV1 TRPV3
2	inflammatory response	GO:0006954	9.33	ADGRE2 MS4A2 TRPV1
3	calcium ion transmembrane transport	GO:0070588	9.32	TRPV1 TRPV3
4	Fc-epsilon receptor signaling pathway	GO:0038095	9.26	FCER1A MS4A2
5	response to heat	GO:0009408	8.96	TRPV1 TRPV3
6	cell surface receptor signaling pathway	GO:0007166	8.8	ADGRE2 MS4A2 TRPV1

Molecular functions related to Physical Urticaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium channel activity	GO:0005262	9.16	TRPV1 TRPV3
2	cation channel activity	GO:0005261	8.96	TRPV1 TRPV3
3	IgE binding	GO:0019863	8.62	FCER1A MS4A2

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Sources for Physical Urticaria

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia