PICA
MCID: PCD001
MIFTS: 30

Pica Disease (PICA)

Categories: Mental diseases, Metabolic diseases

Aliases & Classifications for Pica Disease

MalaCards integrated aliases for Pica Disease:

Name: Pica Disease 12 15 73
Pica 76 44

Classifications:



External Ids:

Disease Ontology 12 DOID:12128
ICD9CM 35 307.52
MeSH 44 D010842
NCIt 50 C92566
SNOMED-CT 68 14077003
UMLS 73 C0031873

Summaries for Pica Disease

Disease Ontology : 12 An eating disorder that is characterized by an appetite for non-nutritive substances or food ingredients.

MalaCards based summary : Pica Disease, also known as pica, is related to lateral medullary syndrome and eating disorder, and has symptoms including constipation, vomiting and abdominal pain. An important gene associated with Pica Disease is OPTN (Optineurin). The drugs Anticholesteremic Agents and Atorvastatin Calcium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and kidney.

Wikipedia : 76 Pica is a psychological disorder characterized by an appetite for substances that are largely... more...

Related Diseases for Pica Disease

Diseases related to Pica Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 lateral medullary syndrome 11.7
2 eating disorder 11.4
3 iron metabolism disease 10.6
4 deficiency anemia 10.4
5 iron deficiency anemia 10.4
6 porphyria, acute hepatic 10.4
7 sickle cell disease 10.2
8 autism 10.1
9 intestinal obstruction 10.1
10 west nile virus 10.1
11 restless legs syndrome 10.1
12 motion sickness 10.0
13 obsessive-compulsive disorder 10.0
14 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 10.0
15 celiac disease 1 9.9
16 anorexia nervosa 9.9
17 alacrima, achalasia, and mental retardation syndrome 9.9
18 vertebral artery occlusion 9.9
19 dementia 9.9
20 avian influenza 9.9
21 pancreatitis 9.9
22 influenza 9.9
23 depression 9.9
24 multiple sclerosis 9.8
25 attention deficit-hyperactivity disorder 9.8
26 schizophrenia 9.8
27 tuberous sclerosis 1 9.8
28 ataxia and polyneuropathy, adult-onset 9.8
29 stroke, ischemic 9.8
30 myocardial infarction 9.8
31 major depressive disorder 9.8
32 malaria 9.8
33 infantile liver failure syndrome 1 9.8
34 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.8
35 brain injury 9.8
36 chronic kidney failure 9.8
37 nephrolithiasis 9.8
38 thalassemia 9.8
39 autism spectrum disorder 9.8
40 aphasia 9.8
41 cardiac arrest 9.8
42 thrombosis 9.8
43 parotitis 9.8
44 eosinophilic meningitis 9.8
45 rumination disorder 9.8
46 porphyria 9.8
47 tuberous sclerosis 9.8
48 eclampsia 9.8
49 status epilepticus 9.8
50 hypogonadism 9.8

Graphical network of the top 20 diseases related to Pica Disease:



Diseases related to Pica Disease

Symptoms & Phenotypes for Pica Disease

UMLS symptoms related to Pica Disease:


constipation, vomiting, abdominal pain, diarrhea, nausea, salt craving, flatulence, signs and symptoms, digestive, decrease in appetite, dyspepsia, heartburn, halitosis, eructation

Drugs & Therapeutics for Pica Disease

Drugs for Pica Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anticholesteremic Agents Phase 4
2 Atorvastatin Calcium Phase 4 134523-03-8
3 Calcium, Dietary Phase 4
4 Lipid Regulating Agents Phase 4
5 Hypolipidemic Agents Phase 4
6 Antimetabolites Phase 4
7 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
8
rituximab Approved Phase 3 174722-31-7 10201696
9
Iron Approved Phase 3 7439-89-6 23925
10
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
11 Antibodies Phase 3,Phase 2
12 Immunoglobulins Phase 3,Phase 2
13 Antirheumatic Agents Phase 3,Phase 2
14 Immunologic Factors Phase 3,Phase 2
15 Micronutrients Phase 3
16 Antioxidants Phase 3
17 Trace Elements Phase 3
18 Iron Supplement Phase 3
19 Vitamins Phase 3
20 Protective Agents Phase 3
21
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
22
Procarbazine Approved, Investigational Phase 2 671-16-9 4915
23
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
24
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
25
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
26
Etoposide Approved Phase 2 33419-42-0 36462
27
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
28
Vinblastine Approved Phase 2 865-21-4 241903 13342
29
Nivolumab Approved Phase 2 946414-94-4
30
Doxil Approved June 1999 Phase 2 31703
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
32 Hormone Antagonists Phase 2
33 Antineoplastic Agents, Phytogenic Phase 2
34 Hormones Phase 2
35 Antineoplastic Agents, Alkylating Phase 2
36 Topoisomerase Inhibitors Phase 2
37 Antibiotics, Antitubercular Phase 2
38 Etoposide phosphate Phase 2
39 Antibodies, Monoclonal Phase 2
40 glucocorticoids Phase 2
41 Antineoplastic Agents, Hormonal Phase 2
42 Anti-Inflammatory Agents Phase 2
43 Antimitotic Agents Phase 2
44 Alkylating Agents Phase 2
45 Anti-Bacterial Agents Phase 2
46 Immunosuppressive Agents Phase 2
47
Parecoxib Approved Not Applicable 198470-84-7
48
Oxycodone Approved, Illicit, Investigational Not Applicable 76-42-6 5284603
49
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
50
Sufentanil Approved, Investigational Not Applicable 56030-54-7 41693

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
2 A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis Recruiting NCT03524092 Phase 3 Mirikizumab;Mirikizumab;Placebo
3 An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1) Recruiting NCT03518086 Phase 3 Mirikizumab;Placebo
4 Follicular Lymphoma IV/SC Rituximab Therapy (FLIRT) Recruiting NCT02303119 Phase 3 Rituximab IV;Rituximab SC
5 Daily vs. Every Other Day Oral Iron Supplementation in Patients With Absolute Iron Deficiency Anemia Not yet recruiting NCT03725384 Phase 3 Ferrous Sulfate 300Mg Tablet;Vitamin C 500Mg tablet
6 Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex in Alcoholism Completed NCT01330394 Phase 2
7 Brentuximab Vedotin as Consolidation Treatment in Patients With Stage I/II HL and PET Positivity After 2 Cycles of ABVD Recruiting NCT02298283 Phase 2 brentuximab vedotin;Cyclophosphamide;Adriamycin;Oncovin;Bleomycin;Etoposide;Procarbazine;Prednisone;G-CSF
8 Study Of Nivolumab Alone, Or In Combination With Vinblastin In Patients With Classical Hodgkin Lymphoma Recruiting NCT03580408 Phase 2 Nivolumab;Vinblastin
9 The Assessments of the Postoperative Recovery on Elderly Patients Received General Anesthesia or Peripheral Nerve Blocks Unknown status NCT01782612 Not Applicable
10 Ultrasound-guided Continuous Adductor Canal Block for Analgesia After Total Knee Replacement: Comparison of Short-axis and Long-axis Techniques Completed NCT02799797 Not Applicable Ropivocaine;rescue sulfentanil given postoperatively as PICA
11 Cognitive-Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder: A Treatment Development and Pilot Study Recruiting NCT02963220 Not Applicable
12 Stress CMR in Patients With Coronary Chronic Total Occlusions Recruiting NCT03152825
13 A Study of Cognitive-Behavioral Therapy for Rumination Disorder Active, not recruiting NCT03113682 Not Applicable
14 A Pilot Study of Cognitive-Behavioral Therapy for Rumination Disorder (CBT-RD) Active, not recruiting NCT03062696 Not Applicable
15 Treating Avoidant/Restrictive Food Intake Disorder (ARFID) Using Family-Based Treatment Active, not recruiting NCT03778216 Not Applicable
16 Prospective Identification of Cardiac Amyloidosis by Cardiac Magnetic Resonance Imaging Withdrawn NCT02462213

Search NIH Clinical Center for Pica Disease

Cochrane evidence based reviews: pica

Genetic Tests for Pica Disease

Anatomical Context for Pica Disease

MalaCards organs/tissues related to Pica Disease:

41
Brain, Liver, Kidney, Lung, Testes, Colon, Bone

Publications for Pica Disease

Articles related to Pica Disease:

(show top 50) (show all 562)
# Title Authors Year
1
Iron-deficiency anemia with lithobezoar (pica): a rare cause of intestinal obstruction in a 5-year-old Nigerian child. ( 30271221 )
2018
2
Pica: Eating disorder. ( 30309086 )
2018
3
Retromedullary Hemangioblastoma Mimicking a PICA Aneurysm: Case Report & Literature Review. ( 30404062 )
2018
4
Pica in end-stage chronic kidney disease: Literature review. ( 30360922 )
2018
5
Development of the Pica, ARFID, and Rumination Disorder Interview, a multi-informant, semi-structured interview of feeding disorders across the lifespan: A pilot study for ages 10-22. ( 30312485 )
2018
6
High susceptibility of magpie (Pica pica) to experimental infection with lineage 1 and 2 West Nile virus. ( 29634743 )
2018
7
Pica is prevalent and strongly associated with iron deficiency among Hispanic pregnant women living in the United States. ( 28864256 )
2018
8
Chemotherapy-Induced Pica in Rats Reduced by Electroacupuncture. ( 29094451 )
2018
9
Running-based pica and taste avoidance in rats. ( 29124569 )
2018
10
Metabolism of the synthetic cannabinoid 5F-PY-PICA by human and rat hepatocytes and identification of biliary analytical targets by directional efflux in sandwich-cultured rat hepatocytes using UHPLC-HR-MS/MS. ( 29128830 )
2018
11
Strain differences in the development of cisplatin-induced pica behavior in mice. ( 29407728 )
2018
12
Right PICA aneurysm with anomalous origins of the right subclavian artery and right vertebral artery: findings on angiography. ( 29488387 )
2018
13
Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA. ( 29549157 )
2018
14
Coin pica-induced gastric perforation resulting from ingestion of 1,894 coins, 8 kg in total: case report and review of published works. ( 29657731 )
2018
15
Prevalence of pica and rumination behaviors in German children aged 7-14 and their associations with feeding, eating, and general psychopathology: a population-based study. ( 29675593 )
2018
16
A Fatal Outcome of Pica Syndrome: An Unusual Case of Delayed Mortality. ( 29771703 )
2018
17
Modified "Extended" Suboccipital Subtonsillar Clipping of a Ruptured Proximal Pica Aneurysm: Technical Note with Relevant Anatomical Demonstration. ( 29902610 )
2018
18
Enhancement of ghrelin-signaling system by Rikkunshi-To attenuates teriparatide-induced pica in rats. ( 29914799 )
2018
19
Evaluation of self-injurious behavior, thermal sensitivity, food intake, fecal output, and pica after injection of three buprenorphine formulations in rats (Rattus norvegicus). ( 29943638 )
2018
20
Correction to: Prevalence of pica and rumination behaviors in German children aged 7-14 and their associations with feeding, eating, and general psychopathology: a population-based study. ( 29948229 )
2018
21
Endovascular treatment of ruptured pica aneurysms and association with its extradural origin: A single-center experience. ( 30050248 )
2018
22
Pica, Lead Poisoning and Public Health. ( 30131351 )
2018
23
Synthesis and pharmacology of new psychoactive substance 5F-CUMYL-P7AICA, a scaffold- hopping analog of synthetic cannabinoid receptor agonists 5F-CUMYL-PICA and 5F-CUMYL-PINACA. ( 30151911 )
2018
24
Prevalence in primary school youth of pica and rumination behavior: The understudied feeding disorders. ( 30175409 )
2018
25
Comparison of Clinical and Radiologic Outcomes of Diverse Endovascular Treatments in Vertebral Artery Dissecting Aneurysm Involving the Origin of PICA. ( 30189304 )
2018
26
Involvement of the Hypothalamic Glutamatergic System in the Development of Radiation-Induced Pica in Rats. ( 30207505 )
2018
27
Pica and the radiologist - beyond the radiology report … digging deeper. ( 30319211 )
2018
28
Prevalence of Pica in Patients on Dialysis and its Association With Nutritional Status. ( 30322787 )
2018
29
Tramadol-associated pica. ( 30367530 )
2018
30
Detection of the recently emerged synthetic cannabinoid 5F-MDMB-PICA in 'legal high' products and human urine samples. ( 28371476 )
2018
31
Pica, constipation and cardiorespiratory arrest. ( 28710201 )
2017
32
The relation between pica and iron deficiency in children in Zanjan, Islamic Republic of Iran: a case-control study. ( 28836652 )
2017
33
Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model. ( 28685428 )
2017
34
Pharmacology of Cumyl-Carboxamide Synthetic Cannabinoid New Psychoactive Substances (NPS) CUMYL-BICA, CUMYL-PICA, CUMYL-5F-PICA, CUMYL-5F-PINACA, and Their Analogues. ( 28792725 )
2017
35
In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA. ( 28824730 )
2017
36
Case 1: Fever and Ataxia in a Toddler with Pica. ( 28864734 )
2017
37
Reply to the 'Comment on "Relating side chain organization of PNIPAm with its conformation in aqueous methanol"' by A. Pica and G. Graziano, Soft Matter, 2017, 13, DOI: 10.1039/C7SM01065F. ( 29057420 )
2017
38
Pica in Pregnancy: An Unusual Presentation. ( 29112667 )
2017
39
Case Report of Foreign Body Stuck in Esophagus with Failure of Endoscopic Management in a Man with a History of Pica. ( 29225989 )
2017
40
Abstract-concept learning in Black-billed magpies (Pica hudsonia). ( 27503195 )
2017
41
Ruptured Distal Posterior Inferior Cerebellar Artery (PICA) Aneurysms Associated with Cerebellar Arterial Venous Malformations (AVMs): A Case Series and Review of the Literature Demonstrating the Need for Angiographic Evaluation and Feasibility of Endovascular Treatment. ( 27793767 )
2017
42
The only case of mycotic aneurysm of the PICA: Clinical-radiological remarks and review of literature. ( 28118952 )
2017
43
Qualitative assessment of pica experienced by frequent blood donors. ( 28164344 )
2017
44
Identification of a new tert-leucinate class synthetic cannabinoid in powder and "spice-like" herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA). ( 28214755 )
2017
45
Transjugular tubercle-preaccessory approach for ventrocaudally located PICA aneurysm. ( 28243811 )
2017
46
Effective nut dispersal by magpies (Pica pica L.) in a Mediterranean agroecosystem. ( 28303393 )
2017
47
A Toddler With Severe Anemia, Pica, and Extremity Swelling. ( 28343690 )
2017
48
Esperance pica study. ( 28376581 )
2017
49
Ethnomedical and Sociocultural Factors of Pica Substances in Rural South India. ( 28418723 )
2017
50
Pica Practices among Apparently Healthy Women and Their Young Children in Ghana. ( 28442334 )
2017

Variations for Pica Disease

Expression for Pica Disease

Search GEO for disease gene expression data for Pica Disease.

Pathways for Pica Disease

GO Terms for Pica Disease

Sources for Pica Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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