PICA
MCID: PCD001
MIFTS: 38

Pica Disease (PICA)

Categories: Mental diseases, Metabolic diseases

Aliases & Classifications for Pica Disease

MalaCards integrated aliases for Pica Disease:

Name: Pica Disease 12 15 70
Pica 73 44

Classifications:



External Ids:

Disease Ontology 12 DOID:12128
ICD9CM 34 307.52
MeSH 44 D010842
NCIt 50 C92566
SNOMED-CT 67 14077003
UMLS 70 C0031873

Summaries for Pica Disease

Disease Ontology : 12 An eating disorder that is characterized by an appetite for non-nutritive substances or food ingredients.

MalaCards based summary : Pica Disease, also known as pica, is related to akinetic mutism and semantic dementia, and has symptoms including constipation, vomiting and abdominal pain. An important gene associated with Pica Disease is KIZ (Kizuna Centrosomal Protein), and among its related pathways/superpathways is Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics. The drugs Ropivacaine and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and prostate.

Wikipedia : 73 Pica (/ˈpaɪkə/ PIE-kuh) is a psychological disorder characterized by an appetite for substances that are... more...

Related Diseases for Pica Disease

Diseases related to Pica Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
# Related Disease Score Top Affiliating Genes
1 akinetic mutism 29.6 TARDBP MAPT
2 semantic dementia 29.4 TARDBP MAPT C9orf72
3 aphasia 29.4 TARDBP MAPT FUS C9orf72
4 mutism 29.3 TARDBP MAPT C9orf72
5 dementia 29.0 TARDBP MAPT FUS C9orf72
6 autosomal dominant cerebellar ataxia 28.9 TARDBP MAPT FUS C9orf72
7 lateral medullary syndrome 11.2
8 eating disorder 11.1
9 iron metabolism disease 10.7
10 aneurysm 10.6
11 deficiency anemia 10.6
12 iron deficiency anemia 10.5
13 intestinal obstruction 10.3
14 obsessive-compulsive disorder 10.2
15 west nile virus 10.2
16 sickle cell disease 10.2
17 autism 10.2
18 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 10.1
19 locked-in syndrome 10.1 TARDBP FUS
20 alacrima, achalasia, and mental retardation syndrome 10.1
21 rumination disorder 10.1
22 frontotemporal dementia and/or amyotrophic lateral sclerosis 2 10.1 FUS C9orf72
23 progressive bulbar palsy 10.1 FUS C9orf72
24 sveinsson chorioretinal atrophy 10.1
25 motion sickness 10.1
26 celiac disease 1 10.1
27 constipation 10.1
28 amyotrophic lateral sclerosis 11 10.1 TARDBP FUS
29 simultanagnosia 10.0 TARDBP MAPT
30 alexia 10.0 TARDBP MAPT
31 giant axonal neuropathy 2 10.0 TARDBP FUS
32 postencephalitic parkinson disease 10.0 TARDBP MAPT
33 anorexia nervosa 10.0
34 autism spectrum disorder 10.0
35 vertebral artery occlusion 10.0
36 placenta disease 10.0
37 progressive non-fluent aphasia 10.0 MAPT C9orf72
38 amyotrophic lateral sclerosis type 12 10.0 TARDBP FUS
39 arteriolosclerosis 10.0 TARDBP MAPT
40 dyscalculia 10.0 TARDBP MAPT
41 corneal dystrophy, posterior polymorphous, 4 10.0 MAF H3-2
42 ataxia and polyneuropathy, adult-onset 10.0
43 major depressive disorder 10.0
44 restless legs syndrome 10.0
45 hydrocephalus 10.0
46 mental depression 10.0
47 hypokalemia 10.0
48 kidney disease 10.0
49 48,xyyy 10.0
50 mercury poisoning 10.0

Graphical network of the top 20 diseases related to Pica Disease:



Diseases related to Pica Disease

Symptoms & Phenotypes for Pica Disease

UMLS symptoms related to Pica Disease:


constipation; vomiting; abdominal pain; diarrhea; nausea; salt craving; halitosis; dyspepsia; signs and symptoms, digestive; decrease in appetite; heartburn; eructation; flatulence

Drugs & Therapeutics for Pica Disease

Drugs for Pica Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved 84057-95-4 71273 175805
2
Sufentanil Approved, Investigational 56030-54-7 41693
3
Oxycodone Approved, Illicit, Investigational 76-42-6 5284603
4
parecoxib Approved 198470-84-7
5 Anesthetics
6 Analgesics
7 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Peripheral Nerve Blocks With General Anesthesia on Elderly Patients Undergoing Total Hip Replacement (THR) by Assessing the Postoperative Recovery and Delirium Unknown status NCT01782612
2 Prevalence of Geophagy and Knowledge About Its Health Effects Among Native Sub-Saharan Africa, Caribbean and South America Healthy Adults Living in France Completed NCT03948126
3 Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load Not yet recruiting NCT03950596

Search NIH Clinical Center for Pica Disease

Cochrane evidence based reviews: pica

Genetic Tests for Pica Disease

Anatomical Context for Pica Disease

MalaCards organs/tissues related to Pica Disease:

40
Brain, Cerebellum, Prostate, Amygdala, Cortex, Skin, Hypothalamus

Publications for Pica Disease

Articles related to Pica Disease:

(show top 50) (show all 2453)
# Title Authors PMID Year
1
Delineability and anatomical variations of perforating arteries from normal vertebral artery on 3D DSA: implications for endovascular treatment of dissecting aneurysms. 61
32955631 2021
2
Olanzapine Administration Reduces Chemotherapy-Induced Nausea Behavior in Rats. 61
33789505 2021
3
Radiation-induced intracranial aneurysm presenting with acute hemorrhage in a child treated for medulloblastoma. 61
32772130 2021
4
Challenges in using the posterior inferior cerebellar artery for revascularization of the anterior inferior cerebellar artery: A microsurgical anatomical study. 61
33753318 2021
5
Relationship of the vascular territory affected by delayed cerebral ischemia and the location of the ruptured aneurysm in patients with aneurysmal subarachnoid hemorrhage. 61
33782797 2021
6
Application of a simultaneous screening method for the detection of new psychoactive substances in various matrix samples using LC-ESI-Tandem MS and LC-QTOF-MS. 61
33656207 2021
7
Widening the Indications for Intrasaccular Flow Disruption: WEB 17 in the Treatment of Aneurysm Locations Different from Those in the Good Clinical Practice Trials. 61
33509918 2021
8
Interdisciplinarity and Integration: An Introduction to the Special Issue on Psychopathology in Medical Settings. 61
33219478 2021
9
Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating. 61
33809564 2021
10
Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays PART II: Structure activity relationship assessment via a β-arrestin recruitment assay. 61
33769699 2021
11
Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays PART I: Synthesis, analytical characterization, and binding affinity for human CB1 receptors. 61
33787091 2021
12
Shape matters: The application of activity-based in vitro bioassays and chiral profiling to the pharmacological evaluation of synthetic cannabinoid receptor agonists in drug-infused papers seized in prisons. 61
33161649 2021
13
Large-scale evaluation of ion mobility spectrometry for the rapid detection of synthetic cannabinoid receptor agonists in infused papers in prisons. 61
33058556 2021
14
Treatment for Hemifacial Spasm Associated with a Dissecting Vertebral Artery Aneurysm Requiring Microvascular Decompression in Addition to Endovascular Trapping: A Case Report with Literature Review. 61
33690877 2021
15
Outcome of Endoscope-Assisted Microvascular Decompression in Patients With Hemifacial Spasm Caused by Severe Indentation of the Brain Stem at the Pontomedullary Sulcus by the Posterior Inferior Cerebellar Artery. 61
33693935 2021
16
PICA injury secondary to anterior odontoid screw fixation: Case report of an exceptional complication. 61
33753130 2021
17
Genome-wide association studies of exacerbations in children using long-acting beta2-agonists. 61
33706416 2021
18
Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. 61
32925604 2021
19
Heavy Metal Assessment in Feathers of Eurasian Magpies (Pica pica): A Possible Strategy for Monitoring Environmental Contamination? 61
33799387 2021
20
Assessment of vertical component of gaze deviation in acute PICA occlusion on Computed Tomography. 61
33799213 2021
21
Pica in Pediatric Sickle Cell Disease. 61
31659594 2021
22
A Toddler With Pain Abdomen and Pica: The 'Concrete' Evidence! 61
33713071 2021
23
High-resolution vessel wall magnetic resonance imaging for depicting imaging features of unruptured intracranial vertebrobasilar dissecting aneurysms. 61
33530789 2021
24
Predictive value on diffusion weighted imaging scores for basilar artery occlusion after endovascular treatment. 61
32640857 2021
25
The Glossopharyngo-Cochlear Triangle-Part I: Quantitative Anatomic Analysis of High-Riding Posterior Inferior Cerebellar Artery Aneurysms Exposed Through the Extended Retrosigmoid Approach. 61
33372996 2021
26
Microsurgical Clipping of a Posterior Inferior Cerebellar Artery Aneurysm Following Failed Pipeline Stent. 61
33791182 2021
27
Evaluation of Synthetic Cannabinoid Metabolites in Human Blood in the Absence of Parent Compounds: A Stability Assessment. 61
32435808 2021
28
The laminar pattern of resting state in human cerebral cortex. 61
33130056 2021
29
The next generation of synthetic cannabinoids: Detection, activity, and potential toxicity of pent-4en and but-3en analogues including MDMB-4en-PINACA. 61
32997377 2021
30
The Glossopharyngo-Cochlear Triangle-Part II: Case Series Highlighting the Clinical Application to High-Riding Posterior Inferior Cerebellar Artery Aneurysms Exposed Through the Extended Retrosigmoid Approach. 61
33372992 2021
31
Far Lateral Approach (Transcondylar, Transtubercular) for Bypass and Trapping of a Ruptured, Dissecting PICA Aneurysm. 61
33717815 2021
32
Esophageal Obstruction and Death in a Nonverbal Patient. 61
33583613 2021
33
A rare complication of pica: Stone aspiration with severe respiratory distress. 61
33605923 2021
34
Pica, Autism, and Other Disabilities. 61
33408069 2021
35
Clinical Implication of Corrective Saccades in the Video Head Impulse Test for the Diagnosis of Posterior Inferior Cerebellar Artery Infarction. 61
33679578 2021
36
Understanding the Deactivation Pathways of Iridium(III) Pyridine-Carboxiamide Catalysts for Formic Acid Dehydrogenation. 61
33141938 2021
37
Computed tomographic angiography to analyze dangerous vertebral artery anomalies at the craniovertebral junction in patients with basilar invagination. 61
33109467 2021
38
Ascending pharyngeal artery-posterior inferior cerebellar artery anastomosis via the jugular foramen: a case report and literature review. 61
33452904 2021
39
Cabardites, a new genus for the "Adites" maculata (Poujade, 1886) species-group, with descriptions of five new species from northern Indochina and eastern China (Lepidoptera: Erebidae: Arctiinae: Lithosiini). 61
33756552 2021
40
Intestinal Histopathology due to an Acanthocephalan in Two Corvid Species from Northern Italy. 61
33635988 2021
41
A highly sensitive electrochemiluminescence immunosensor for h-FABP determination based on self-enhanced luminophore coupled with ultrathin 2D nickel metal-organic framework nanosheets. 61
33075723 2021
42
Trichotillomania due to pica in a 23-month-old patient with concomitant iron deficiency anemia and lead poisoning. 61
33364276 2021
43
Cerebellar hemorrhage in a newborn: a case report in association with suspected arterial dissection of the posterior inferior cerebellar artery. 61
33506303 2021
44
Successful rescue treatment of right posterior inferior cerebellar artery (PICA) vascular stasis with tirofiban following endovascular coil implantation. 61
33500304 2021
45
A case of pica and elevated lead levels in a child. 61
33543166 2021
46
A systematic review of the effectiveness of behavioural treatments for pica in youths. 61
32628326 2021
47
Radiographic horizontal gaze deviation in the setting of acute PICA territory ischemia: A potential mimic of large vessel occlusion. 61
33316616 2021
48
Efficacy of microvascular decompression on the vascular compression type of neurogenic hypertension: A meta-analysis. 61
32169328 2020
49
Detection of synthetic cannabinoid adulteration in the unregulated drug supply in three Canadian settings. 61
33354869 2020
50
Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors. 61
33303809 2020

Variations for Pica Disease

Expression for Pica Disease

Search GEO for disease gene expression data for Pica Disease.

Pathways for Pica Disease

Pathways related to Pica Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.92 LEP INS

GO Terms for Pica Disease

Cellular components related to Pica Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 main axon GO:0044304 8.62 MAPT C9orf72

Biological processes related to Pica Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of insulin receptor signaling pathway GO:0046628 9.26 LEP INS
2 stress granule assembly GO:0034063 9.16 MAPT C9orf72
3 central nervous system neuron development GO:0021954 8.96 MAPT LEP
4 regulation of chromatin assembly or disassembly GO:0001672 8.62 TLK2 TLK1

Sources for Pica Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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