Pigmented Nodular Adrenocortical Disease, Primary, 4 (PPNAD4)

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OMIM 56 615830 OMIM Phenotypic Series 56 PS610489 MeSH 43 D003480

MedGen 41 C4014425 CN188261 SNOMED-CT via HPO 68 11381005 161831008 18963009 21061000119107 24184005 247427007 249939004 262286000 263681008 278040002 302227002 312894000 35489007 38341003 399939002 419920004 424131007 425075004 56317004 64859006 73211009 77643000 78441005 78667006 8943002 more UMLS 71 C4014425

UniProtKB/Swiss-Prot : ⁷³ Primary pigmented nodular adrenocortical disease 4: A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow- to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.

MalaCards based summary : Pigmented Nodular Adrenocortical Disease, Primary, 4, is also known as chromosome 19p13 duplication syndrome, and has symptoms including cushingoid facies An important gene associated with Pigmented Nodular Adrenocortical Disease, Primary, 4 is PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha). Affiliated tissues include adrenal gland, cortex and skin, and related phenotypes are acne and osteopenia

OMIM : ⁵⁶ Cushing syndrome is a clinical designation for the systemic signs and symptoms arising from excess cortisol production. Affected individuals typically show hypertension, impaired glucose tolerance, central obesity, osteoporosis, and sometimes depression. Corticotropin-independent Cushing syndrome results from autonomous cortisol production by the adrenal glands, often associated with adrenocortical tumors. Adrenocortical tumors are most common in adult females (summary by Cao et al., 2014; Sato et al., 2014). (615830)

Clinical features from OMIM:

615830

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