MCID: PGM001
MIFTS: 53

Pigmented Villonodular Synovitis

Categories: Rare diseases, Bone diseases, Reproductive diseases, Muscle diseases

Aliases & Classifications for Pigmented Villonodular Synovitis

MalaCards integrated aliases for Pigmented Villonodular Synovitis:

Name: Pigmented Villonodular Synovitis 12 76 53 59 15 73
Tenosynovial Giant Cell Tumor 53 59
Diffuse-Type Giant Cell Tumor 53 59
Diffuse-Type Gct 53 59
Tsgct 53 59
Tgct 53 59
Localized Pigmented Villonodular Synovitis 53
Diffuse Giant Cell Tumor of Tenosynovium 12
Diffuse Pigmented Villonodular Synovitis 53
Fibrous Histiocytoma of Tendon Sheath 73
Synovitis, Pigmented Villonodular 44
Synovitis Pigmented Villonodular 55
Tenosynovial Giant Cell Tumors 53
Testicular Germ Cell Tumor 73
Villous Tenosynovitis 12

Characteristics:

Orphanet epidemiological data:

59
pigmented villonodular synovitis
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:2702
ICD10 33 M12.2
MeSH 44 D013586
NCIt 50 C3401
Orphanet 59 ORPHA66627
MESH via Orphanet 45 D013586
UMLS via Orphanet 74 C0039106
ICD10 via Orphanet 34 M12.2
UMLS 73 C0039106

Summaries for Pigmented Villonodular Synovitis

NIH Rare Diseases : 53 Pigmented villonodular synovitis (PVNS) is a disease in which the tissue lining the joints and tendons in the body (synovium) grows abnormally. It is characterized by a noncancerous mass or tumor. There are two types of PVNS: the local or nodular form (where the tumor involves the tendons that support the joint, or in one area of the joint) and the diffuse form (where the entire lining of the joint is involved). Symptoms might include: pain, limitation of movement, and locking of the joint. In some cases, the normal joint structure can be destroyed. The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, wrist, and rarely the jaw. The average age of diagnosis for this condition is 35 years. The cause of PVNS is unknown. Treatment involves surgery to remove the tumor and damaged portions of the synovium.

MalaCards based summary : Pigmented Villonodular Synovitis, also known as tenosynovial giant cell tumor, is related to villonodular synovitis and tenosynovial giant cell tumor, and has symptoms including pain An important gene associated with Pigmented Villonodular Synovitis is CSF1 (Colony Stimulating Factor 1), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Related Diseases for Pigmented Villonodular Synovitis

Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 villonodular synovitis 32.6 ACP5 MMP9 PTPN11 TNFSF11
2 tenosynovial giant cell tumor 31.2 CSF1 CSF1R
3 malignant giant cell tumor 30.4 ACP5 TP53
4 arthritis 30.3 CSF1 MMP9 TNFSF11
5 bone giant cell tumor 30.3 ACP5 CALCR
6 giant cell tumor 30.1 CSF1 MMP9 PTPRC TNFSF11
7 rheumatoid arthritis 29.0 ACP5 CSF1 CSF1R MMP9 TNFSF11
8 noonan syndrome 1 12.1
9 testicular germ cell tumor 12.1
10 synovitis 11.4
11 multicentric carpotarsal osteolysis syndrome 10.5 ACP5 TNFSF11
12 periapical periodontitis 10.5 ACP5 TNFSF11
13 tooth resorption 10.5 ACP5 TNFSF11
14 glucocorticoid-induced osteoporosis 10.5 ACP5 TNFSF11
15 enchondromatosis, multiple, ollier type 10.5 ACP5 PTPN11
16 ischemic bone disease 10.4 ACP5 TNFSF11
17 mandibular cancer 10.4 CSF1 TNFSF11
18 malignant giant cell tumor of soft parts 10.4 ACP5 PTPRC
19 periodontosis 10.4 MMP9 TNFSF11
20 jaw cancer 10.4 CSF1 TNFSF11
21 teeth hard tissue disease 10.4 ACP5 TNFSF11
22 joint disorders 10.3 CSF1 TNFSF11
23 popliteal cyst 10.3
24 osteonecrosis 10.3
25 sarcoma 10.3
26 synovium cancer 10.3
27 neuropathy 10.3
28 synovial chondromatosis 10.3
29 photokeratitis 10.2 MMP9 PTPRC
30 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.2 CSF1 CSF1R
31 testicular germ cell tumor 1 10.2
32 germ cells tumors 10.2
33 carpal tunnel syndrome 10.2
34 mononeuropathy of the median nerve, mild 10.2
35 osteoarthritis 10.2
36 hemarthrosis 10.2
37 endosteal hyperostosis, autosomal dominant 10.1 CSF1 TNFSF11
38 bone resorption disease 10.1 ACP5 TNFSF11
39 cherubism 10.1 CSF1 PTPN11 TNFSF11
40 paget's disease of bone 10.0 ACP5 CSF1 TNFSF11
41 primary progressive multiple sclerosis 10.0 CSF1R MMP9
42 malignant histiocytosis 10.0 CSF1 CSF1R
43 spondyloarthropathy 1 10.0
44 systemic lupus erythematosus 10.0
45 chediak-higashi syndrome 10.0
46 sarcoma, synovial 10.0
47 hemangioma 10.0
48 lymphoma 10.0
49 squamous cell carcinoma 10.0
50 melanoma 10.0

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to Pigmented Villonodular Synovitis

Symptoms & Phenotypes for Pigmented Villonodular Synovitis

UMLS symptoms related to Pigmented Villonodular Synovitis:


pain

GenomeRNAi Phenotypes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.68 PTPRC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.68 PTPN11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 CALCR PTPN11 PTPRC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 PTPN11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.68 CALCR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.68 PTPN11 PTPRC
7 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.68 PTPN11
8 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.68 PTPN11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.68 CALCR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.68 PTPRC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.68 PTPRC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 CALCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.68 PTPN11
14 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.68 PTPRC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.68 PTPN11
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.68 PTPRC
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 PTPN11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.68 PTPN11
19 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.68 CALCR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.68 CALCR
21 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.26 CSF1R PTPN11 PTPRC ACP5

MGI Mouse Phenotypes related to Pigmented Villonodular Synovitis:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 CALCR CSF1 MMP9 PTPN11 CSF1R PTPRC
2 homeostasis/metabolism MP:0005376 10.13 CALCR CSF1 MMP9 CSF1R PTPRC TP53
3 immune system MP:0005387 10.11 CALCR CSF1 MMP9 PTPN11 CSF1R PTPRC
4 growth/size/body region MP:0005378 10.1 CSF1R MMP9 CSF1 PTPN11 TNFSF11 PTPRC
5 mortality/aging MP:0010768 10.06 CSF1R CALCR CSF1 MMP9 PTPN11 TNFSF11
6 endocrine/exocrine gland MP:0005379 10.04 CSF1R CSF1 PTPN11 TNFSF11 PTPRC TP53
7 limbs/digits/tail MP:0005371 10.02 CSF1 MMP9 PTPN11 CSF1R CALCR TP53
8 craniofacial MP:0005382 9.97 CSF1R CSF1 PTPN11 TNFSF11 TP53
9 integument MP:0010771 9.97 CSF1 MMP9 CSF1R PTPN11 TNFSF11 TP53
10 hearing/vestibular/ear MP:0005377 9.85 TP53 CSF1R CSF1 PTPN11
11 no phenotypic analysis MP:0003012 9.85 CSF1 PTPN11 CSF1R PTPRC TP53 TNFSF11
12 muscle MP:0005369 9.83 MMP9 CSF1 PTPN11 TNFSF11 TP53
13 neoplasm MP:0002006 9.8 MMP9 TNFSF11 PTPRC TP53 PTPN11
14 normal MP:0002873 9.8 CSF1R CALCR PTPN11 TNFSF11 PTPRC TP53
15 reproductive system MP:0005389 9.73 CSF1R CSF1 MMP9 PTPN11 TNFSF11 TP53
16 respiratory system MP:0005388 9.63 CSF1 MMP9 PTPN11 PTPRC TP53 TNFSF11
17 skeleton MP:0005390 9.56 CALCR CSF1 MMP9 PTPN11 CSF1R PTPRC
18 vision/eye MP:0005391 9.02 TP53 MMP9 CSF1 TNFSF11 PTPN11

Drugs & Therapeutics for Pigmented Villonodular Synovitis

Drugs for Pigmented Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
6
Warfarin Approved Phase 1 81-81-2 6691 54678486
7
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
8
Phytonadione Approved, Investigational, Nutraceutical Phase 1 84-80-0 4812 5284607
9 Albumin-Bound Paclitaxel Phase 1
10 Antimitotic Agents Phase 1
11 Antineoplastic Agents, Phytogenic Phase 1
12 Adjuvants, Anesthesia Phase 1
13 Anesthetics Phase 1
14 Anesthetics, General Phase 1
15 Anesthetics, Intravenous Phase 1
16 Anti-Anxiety Agents Phase 1
17 Anticoagulants Phase 1
18 Antifibrinolytic Agents Phase 1
19 Central Nervous System Depressants Phase 1
20 Coagulants Phase 1
21 GABA Agents Phase 1
22 GABA Modulators Phase 1
23 Hemostatics Phase 1
24 Hypnotics and Sedatives Phase 1
25 Micronutrients Phase 1
26 Neurotransmitter Agents Phase 1
27 Psychotropic Drugs Phase 1
28 Trace Elements Phase 1
29 Tranquilizing Agents Phase 1
30 Vitamins Phase 1
31 Menaquinone Nutraceutical Phase 1
32 naphthoquinone Nutraceutical Phase 1
33 Vitamin K Nutraceutical Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2
4 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Completed NCT01494688 Phase 1 Paclitaxel;RO5509554
7 Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics) Recruiting NCT03291288 Phase 1 Tolbutamide;Midazolam;Pexidartinib
8 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Terminated NCT02673736 Phase 1 PLX73086
9 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Terminated NCT01804530 Phase 1 PLX7486 TsOH
10 Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children Recruiting NCT03507933
11 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Pigmented Villonodular Synovitis

Cochrane evidence based reviews: synovitis, pigmented villonodular

Genetic Tests for Pigmented Villonodular Synovitis

Anatomical Context for Pigmented Villonodular Synovitis

MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

41
Bone, Testes, Lung

Publications for Pigmented Villonodular Synovitis

Articles related to Pigmented Villonodular Synovitis:

(show top 50) (show all 608)
# Title Authors Year
1
Recurrent pigmented villonodular synovitis of the temporomandibular joint. ( 29904498 )
2018
2
Pigmented villonodular synovitis managed by total synovectomy and cementless total hip arthroplasty. ( 29700612 )
2018
3
Diffuse Pigmented Villonodular Synovitis Around the Ankle. ( 29634303 )
2018
4
Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. ( 29594178 )
2018
5
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
6
Nilotinib in locally advanced pigmented villonodular synovitis: challenges of a new targeted therapy. ( 29571947 )
2018
7
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
8
Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents. ( 29917011 )
2018
9
Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review. ( 29504995 )
2018
10
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
11
Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results. ( 29727868 )
2018
12
Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial. ( 29571946 )
2018
13
Computed Tomography Findings of Pigmented Villonodular Synovitis in a Dog. ( 29864767 )
2018
14
Lowering the recurrence rate in pigmented villonodular synovitis: A series of 120 resections. ( 29788491 )
2018
15
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
16
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
17
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
18
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
19
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
20
Arthroscopic treatment of intra-artricularly localised pigmented villonodular synovitis of the ankle: 4 cases with long-term follow-up. ( 29202997 )
2017
21
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
22
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
23
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
24
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
25
Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis. ( 29352684 )
2017
26
A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours. ( 28978573 )
2017
27
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
28
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy. ( 29282525 )
2017
29
Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee. ( 29354472 )
2017
30
Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? ( 28389877 )
2017
31
Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. ( 28884104 )
2017
32
Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre. ( 28442184 )
2017
33
Localized pigmented villonodular synovitis in a child knee. ( 28291439 )
2017
34
Pigmented Villonodular Synovitis of the Temporomandibular Joint With Petrous Bone Invasion. ( 28333775 )
2017
35
Intra-articular Localized Haemangioma of the Knee Mimicking Localized Pigmented Villonodular Synovitis: A Case Report. ( 28435577 )
2017
36
Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis. ( 28764182 )
2017
37
Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study. ( 28436371 )
2017
38
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. ( 26761914 )
2016
39
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. ( 27130398 )
2016
40
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. ( 27509331 )
2016
41
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. ( 28005642 )
2016
42
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. ( 27866235 )
2016
43
Pigmented villonodular synovitis of the hip. ( 28461957 )
2016
44
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. ( 27517031 )
2016
45
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. ( 27928593 )
2016
46
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. ( 27169531 )
2016
47
Functional Reconstruction of Temporomandibular Joint after Resection of Pigmented Villonodular Synovitis with Extension to Infratemporal Fossa and Skull Base: A Case Report. ( 28824995 )
2016
48
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. ( 27499236 )
2016
49
Multifocal pigmented villonodular synovitis in a child: A case report. ( 27537585 )
2016
50
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. ( 27843734 )
2016

Variations for Pigmented Villonodular Synovitis

Expression for Pigmented Villonodular Synovitis

Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for Pigmented Villonodular Synovitis

Pathways related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CSF1 CSF1R MMP9 PTPN11 PTPRC TNFSF11
2
Show member pathways
12.94 CSF1 CSF1R PTPN11 PTPRC TNFSF11
3
Show member pathways
12.84 CSF1 CSF1R MMP9 PTPN11 TNFSF11 TP53
4
Show member pathways
12.54 CSF1R MMP9 PTPN11 TP53
5
Show member pathways
12.15 ACP5 CALCR TNFSF11
6 12 MMP9 PTPN11 TP53
7 11.96 CSF1R MMP9 TP53
8 11.58 CSF1R PTPN11 PTPRC
9 11.53 ACP5 CSF1 TNFSF11
10 11.43 MMP9 PTPN11 PTPRC
11 11.37 CSF1 CSF1R PTPRC
12
Show member pathways
11.33 CSF1 CSF1R
13 11.31 PTPN11 TP53
14 11.3 CSF1 CSF1R
15 11.26 MMP9 PTPN11
16 11.24 CALCR TNFSF11
17
Show member pathways
11.19 CSF1 CSF1R
18 11.16 PTPN11 PTPRC
19 11.13 ACP5 CALCR CSF1 CSF1R TNFSF11
20 11.04 MMP9 PTPRC
21 11.01 CSF1 CSF1R TNFSF11
22 10.79 CSF1 CSF1R PTPN11
23 10.64 ACP5 TNFSF11

GO Terms for Pigmented Villonodular Synovitis

Cellular components related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.7 CALCR CSF1R PTPN11
2 positive regulation of cell migration GO:0030335 9.69 CSF1 CSF1R MMP9
3 dephosphorylation GO:0016311 9.61 ACP5 PTPN11 PTPRC
4 cellular response to cytokine stimulus GO:0071345 9.54 CSF1R PTPN11
5 positive regulation of protein kinase B signaling GO:0051897 9.54 CALCR PTPN11 TNFSF11
6 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.49 MMP9 TP53
7 homeostasis of number of cells within a tissue GO:0048873 9.48 CSF1 PTPN11
8 bone resorption GO:0045453 9.46 ACP5 TNFSF11
9 cytokine-mediated signaling pathway GO:0019221 9.43 CSF1 CSF1R MMP9 PTPN11 TNFSF11 TP53
10 positive regulation of osteoclast differentiation GO:0045672 9.4 CSF1 TNFSF11
11 macrophage differentiation GO:0030225 9.33 CSF1 CSF1R MMP9
12 osteoclast proliferation GO:0002158 9.32 CSF1 TNFSF11
13 macrophage colony-stimulating factor signaling pathway GO:0038145 9.26 CSF1 CSF1R
14 osteoclast differentiation GO:0030316 8.92 CALCR CSF1 CSF1R TNFSF11

Molecular functions related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 PTPN11 TP53

Sources for Pigmented Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....