TGCT
MCID: PGM001
MIFTS: 54

Pigmented Villonodular Synovitis (TGCT)

Categories: Bone diseases, Muscle diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Pigmented Villonodular Synovitis

MalaCards integrated aliases for Pigmented Villonodular Synovitis:

Name: Pigmented Villonodular Synovitis 12 76 53 59 15 73
Tenosynovial Giant Cell Tumor 53 59
Diffuse-Type Giant Cell Tumor 53 59
Diffuse-Type Gct 53 59
Tsgct 53 59
Tgct 53 59
Localized Pigmented Villonodular Synovitis 53
Diffuse Giant Cell Tumor of Tenosynovium 12
Diffuse Pigmented Villonodular Synovitis 53
Fibrous Histiocytoma of Tendon Sheath 73
Synovitis, Pigmented Villonodular 44
Synovitis Pigmented Villonodular 55
Tenosynovial Giant Cell Tumors 53
Testicular Germ Cell Tumor 73
Villous Tenosynovitis 12

Characteristics:

Orphanet epidemiological data:

59
pigmented villonodular synovitis
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:2702
ICD10 33 M12.2
MeSH 44 D013586
NCIt 50 C3401
SNOMED-CT 68 71508003 95412009
Orphanet 59 ORPHA66627
MESH via Orphanet 45 D013586
UMLS via Orphanet 74 C0039106
ICD10 via Orphanet 34 M12.2

Summaries for Pigmented Villonodular Synovitis

NIH Rare Diseases : 53 Pigmented villonodular synovitis (PVNS) is a disease in which the tissue lining the joints and tendons in the body (synovium) grows abnormally. It is characterized by a noncancerous mass or tumor. There are two types of PVNS: the local or nodular form (where the tumor involves the tendons that support the joint, or in one area of the joint) and the diffuse form (where the entire lining of the joint is involved). Symptoms might include: pain, limitation of movement, and locking of the joint. In some cases, the normal joint structure can be destroyed. The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, wrist, and rarely the jaw. The average age of diagnosis for this condition is 35 years. The cause of PVNS is unknown. Treatment involves surgery to remove the tumor and damaged portions of the synovium.

MalaCards based summary : Pigmented Villonodular Synovitis, also known as tenosynovial giant cell tumor, is related to villonodular synovitis and tenosynovial giant cell tumor, and has symptoms including pain An important gene associated with Pigmented Villonodular Synovitis is CSF1 (Colony Stimulating Factor 1), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Grapefruit Seed Extract and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Related Diseases for Pigmented Villonodular Synovitis

Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 villonodular synovitis 33.1 ACP5 MMP9 PTPN11 TNFSF11
2 tenosynovial giant cell tumor 31.2 CSF1 CSF1R
3 giant cell tumor 31.0 CSF1 MMP9 PTPRC TNFSF11
4 arthritis 30.9 CSF1 MMP9 TNFSF11
5 malignant giant cell tumor 30.6 ACP5 TP53
6 rheumatoid arthritis 30.4 ACP5 CSF1 CSF1R MMP9 TNFSF11
7 paget's disease of bone 30.3 ACP5 CSF1 TNFSF11
8 bone giant cell tumor 30.2 ACP5 CALCR TNFSF11
9 noonan syndrome 1 12.2
10 testicular germ cell tumor 12.2
11 synovitis 11.6
12 popliteal cyst 10.5
13 osteonecrosis 10.4
14 sarcoma 10.4
15 neuropathy 10.4
16 tenosynovitis 10.4
17 synovial chondromatosis 10.4
18 carpal tunnel syndrome 10.3
19 mononeuropathy of the median nerve, mild 10.3
20 osteoarthritis 10.3
21 melanoma 10.3
22 synovium cancer 10.3
23 hemarthrosis 10.3
24 testicular germ cell tumor 1 10.3
25 germ cells tumors 10.3
26 testicular cancer 10.2
27 periapical periodontitis 10.2 ACP5 TNFSF11
28 tooth resorption 10.2 ACP5 TNFSF11
29 spondyloarthropathy 1 10.2
30 systemic lupus erythematosus 10.2
31 chediak-higashi syndrome 10.2
32 sarcoma, synovial 10.2
33 xanthomatosis 10.2
34 hemangioma 10.2
35 lymphoma 10.2
36 frozen shoulder 10.2
37 squamous cell carcinoma 10.2
38 chondroblastoma 10.2
39 nodular tenosynovitis 10.2
40 bursitis 10.2
41 peroneal neuropathy 10.2
42 ulnar neuropathy 10.2
43 paraplegia 10.2
44 epithelioid sarcoma 10.2
45 spondylitis 10.2
46 synovial angioma 10.2
47 lupus erythematosus 10.2
48 pseudo-turner syndrome 10.2
49 radiation induced cancer 10.2
50 soft tissue sarcoma 10.2

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to Pigmented Villonodular Synovitis

Symptoms & Phenotypes for Pigmented Villonodular Synovitis

UMLS symptoms related to Pigmented Villonodular Synovitis:


pain

GenomeRNAi Phenotypes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.68 PTPRC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.68 PTPN11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 CALCR PTPN11 PTPRC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 PTPN11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.68 CALCR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.68 PTPN11 PTPRC
7 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.68 PTPN11
8 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.68 PTPN11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.68 CALCR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.68 PTPRC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.68 PTPRC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 CALCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.68 PTPN11
14 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.68 PTPRC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.68 PTPN11
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.68 PTPRC
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 PTPN11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.68 PTPN11
19 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.68 CALCR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.68 CALCR
21 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.26 ACP5 CSF1R PTPN11 PTPRC

MGI Mouse Phenotypes related to Pigmented Villonodular Synovitis:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 CALCR CSF1 CSF1R MMP9 PTPN11 PTPRC
2 homeostasis/metabolism MP:0005376 10.13 CALCR CSF1 CSF1R MMP9 PTPN11 PTPRC
3 immune system MP:0005387 10.11 CALCR CSF1 CSF1R MMP9 PTPN11 PTPRC
4 growth/size/body region MP:0005378 10.1 CSF1 CSF1R MMP9 PTPN11 PTPRC TNFSF11
5 mortality/aging MP:0010768 10.06 CALCR CSF1 CSF1R MMP9 PTPN11 PTPRC
6 endocrine/exocrine gland MP:0005379 10.04 CSF1 CSF1R PTPN11 PTPRC TNFSF11 TP53
7 limbs/digits/tail MP:0005371 10.02 CALCR CSF1 CSF1R MMP9 PTPN11 TNFSF11
8 craniofacial MP:0005382 9.97 CSF1 CSF1R PTPN11 TNFSF11 TP53
9 integument MP:0010771 9.97 CSF1 CSF1R MMP9 PTPN11 TNFSF11 TP53
10 hearing/vestibular/ear MP:0005377 9.85 CSF1 CSF1R PTPN11 TP53
11 no phenotypic analysis MP:0003012 9.85 CSF1 CSF1R PTPN11 PTPRC TNFSF11 TP53
12 muscle MP:0005369 9.83 CSF1 MMP9 PTPN11 TNFSF11 TP53
13 neoplasm MP:0002006 9.8 MMP9 PTPN11 PTPRC TNFSF11 TP53
14 normal MP:0002873 9.8 CALCR CSF1R PTPN11 PTPRC TNFSF11 TP53
15 reproductive system MP:0005389 9.73 CSF1 CSF1R MMP9 PTPN11 TNFSF11 TP53
16 respiratory system MP:0005388 9.63 CSF1 MMP9 PTPN11 PTPRC TNFSF11 TP53
17 skeleton MP:0005390 9.56 CALCR CSF1 CSF1R MMP9 PTPN11 PTPRC
18 vision/eye MP:0005391 9.02 CSF1 MMP9 PTPN11 TNFSF11 TP53

Drugs & Therapeutics for Pigmented Villonodular Synovitis

Drugs for Pigmented Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Grapefruit Seed Extract Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Antibodies Phase 1, Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5
Tolbutamide Approved, Investigational Phase 1 64-77-7 5505
6
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
7 Antineoplastic Agents, Phytogenic Phase 1
8 Albumin-Bound Paclitaxel Phase 1
9 Antimitotic Agents Phase 1
10 Hypnotics and Sedatives Phase 1
11 Anti-Anxiety Agents Phase 1
12 Hypoglycemic Agents Phase 1
13 Central Nervous System Depressants Phase 1
14 GABA Agents Phase 1
15 Neurotransmitter Agents Phase 1
16 Anesthetics, General Phase 1
17 Anesthetics, Intravenous Phase 1
18 Tranquilizing Agents Phase 1
19 Anesthetics Phase 1
20 Adjuvants, Anesthesia Phase 1
21 Psychotropic Drugs Phase 1
22 GABA Modulators Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo
4 Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Active, not recruiting NCT02471716 Phase 1, Phase 2
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Completed NCT01494688 Phase 1 Paclitaxel;RO5509554
7 Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics) Active, not recruiting NCT03291288 Phase 1 Tolbutamide;Midazolam;Pexidartinib
8 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Terminated NCT02673736 Phase 1 PLX73086
9 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Terminated NCT01804530 Phase 1 PLX7486 TsOH
10 Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children Recruiting NCT03507933
11 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Pigmented Villonodular Synovitis

Cochrane evidence based reviews: synovitis, pigmented villonodular

Genetic Tests for Pigmented Villonodular Synovitis

Anatomical Context for Pigmented Villonodular Synovitis

MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

41
Bone, Skin, Brain, Thyroid, B Cells, Myeloid, Bone Marrow

Publications for Pigmented Villonodular Synovitis

Articles related to Pigmented Villonodular Synovitis:

(show top 50) (show all 735)
# Title Authors Year
1
Recurrent pigmented villonodular synovitis of the temporomandibular joint. ( 29904498 )
2018
2
Pigmented villonodular synovitis managed by total synovectomy and cementless total hip arthroplasty. ( 29700612 )
2018
3
Diffuse Pigmented Villonodular Synovitis Around the Ankle. ( 29634303 )
2018
4
Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. ( 29594178 )
2018
5
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
6
Nilotinib in locally advanced pigmented villonodular synovitis: challenges of a new targeted therapy. ( 29571947 )
2018
7
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
8
Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents. ( 29917011 )
2018
9
Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review. ( 29504995 )
2018
10
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
11
Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results. ( 29727868 )
2018
12
Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial. ( 29571946 )
2018
13
Computed Tomography Findings of Pigmented Villonodular Synovitis in a Dog. ( 29864767 )
2018
14
Hot shoulder PET/CT lesion: Unusual presentation of tenosynovial giant cell tumor. ( 29988775 )
2018
15
Tenosynovial giant cell tumor: case report of a patient effectively treated with pexidartinib (PLX3397) and review of the literature. ( 30002809 )
2018
16
Giant Cell Poor Extra-Articular Diffuse-Type Tenosynovial Giant Cell Tumor With Extensive Desmin Expression: A Potential Diagnostic Pitfall With Cytogenetic Confirmation. ( 30019981 )
2018
17
Tenosynovial Giant Cell Tumor of the Clinoid: Rare Condition. ( 30026165 )
2018
18
Malignant Tenosynovial Giant Cell Tumor: The True "Synovial Sarcoma?" A Clinicopathologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases, Supporting Origin from Synoviocytes. ( 30206409 )
2018
19
Intra-articular fibroma-like perivascular epithelioid tumor (PEComa) mimicking tenosynovial giant cell tumor, diffuse type. ( 30206676 )
2018
20
Desmoplastic fibroblastoma mimicking tenosynovial giant cell tumor encasing a tendon of the foot. ( 30229348 )
2018
21
Lowering the recurrence rate in pigmented villonodular synovitis: A series of 120 resections. ( 29788491 )
2018
22
Localized Pigmented Villonodular Synovitis of the Posterior Knee Compartment with Popliteal Vessel Compression: A Case Report of Arthroscopic Resection Using Only Anterior Knee Portals. ( 30034899 )
2018
23
BILATERAL LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS OF THE KNEE: CASE REPORT AND REVIEW. ( 30038543 )
2018
24
Diffuse Pigmented Villonodular Synovitis of the Subtalar Joint. ( 30039025 )
2018
25
A Rare Incidence of Pigmented Villonodular Synovitis of the Ankle in an Adolescent. ( 30146337 )
2018
26
Modified Lemaire extra-articular stabilisation of the knee for the treatment of anterolateral instability combined with diffuse pigmented villonodular synovitis: a case report. ( 30205827 )
2018
27
The predictive value of preoperative neutrophil-lymphocyte ratio (NLR) on the recurrence of the local pigmented villonodular synovitis of the knee joint. ( 30227838 )
2018
28
Complications After Total Knee Arthroplasty in Patients With Pigmented Villonodular Synovitis. ( 30266323 )
2018
29
Pigmented villonodular synovitis does not influence the outcome following cementless total hip arthroplasty using ceramic-on-ceramic articulation: a case-control study with middle-term follow-up. ( 30458820 )
2018
30
Pigmented villonodular synovitis occurring in the temporomandibular joint. ( 30497770 )
2018
31
The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee. ( 30539286 )
2018
32
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
33
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
34
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
35
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
36
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
37
Arthroscopic treatment of intra-artricularly localised pigmented villonodular synovitis of the ankle: 4 cases with long-term follow-up. ( 29202997 )
2017
38
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
39
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
40
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
41
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
42
Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis. ( 29352684 )
2017
43
A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours. ( 28978573 )
2017
44
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
45
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy. ( 29282525 )
2017
46
Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee. ( 29354472 )
2017
47
Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? ( 28389877 )
2017
48
Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. ( 28884104 )
2017
49
Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre. ( 28442184 )
2017
50
Localized pigmented villonodular synovitis in a child knee. ( 28291439 )
2017

Variations for Pigmented Villonodular Synovitis

Expression for Pigmented Villonodular Synovitis

Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for Pigmented Villonodular Synovitis

Pathways related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CSF1 CSF1R MMP9 PTPN11 PTPRC TNFSF11
2
Show member pathways
12.94 CSF1 CSF1R PTPN11 PTPRC TNFSF11
3
Show member pathways
12.84 CSF1 CSF1R MMP9 PTPN11 TNFSF11 TP53
4
Show member pathways
12.67 MMP9 PTPRC TNFSF11 TP53
5
Show member pathways
12.54 CSF1R MMP9 PTPN11 TP53
6
Show member pathways
12.16 CSF1R PTPN11 PTPRC
7
Show member pathways
12.14 ACP5 CALCR TNFSF11
8 12 MMP9 PTPN11 TP53
9
Show member pathways
11.97 PTPN11 TNFSF11 TP53
10 11.96 CSF1R MMP9 TP53
11 11.55 CSF1R PTPN11 PTPRC
12 11.53 ACP5 CSF1 TNFSF11
13 11.43 MMP9 PTPN11 PTPRC
14 11.37 CSF1 CSF1R PTPRC
15
Show member pathways
11.35 CSF1 CSF1R
16 11.34 PTPN11 TP53
17 11.32 CSF1 CSF1R
18 11.28 MMP9 PTPN11
19 11.26 CSF1R PTPRC
20 11.25 CALCR TNFSF11
21
Show member pathways
11.21 CSF1 CSF1R
22 11.18 PTPN11 PTPRC
23 11.13 ACP5 CALCR CSF1 CSF1R TNFSF11
24 11.06 MMP9 PTPRC
25 11.01 CSF1 CSF1R TNFSF11
26 10.79 CSF1 CSF1R PTPN11
27 10.66 ACP5 TNFSF11

GO Terms for Pigmented Villonodular Synovitis

Cellular components related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.73 CSF1 CSF1R MMP9
2 positive regulation of gene expression GO:0010628 9.73 CALCR CSF1 TNFSF11 TP53
3 dephosphorylation GO:0016311 9.67 ACP5 PTPN11 PTPRC
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 CALCR CSF1R PTPN11 PTPRC
5 positive regulation of protein kinase B signaling GO:0051897 9.63 CALCR PTPN11 TNFSF11
6 ossification GO:0001503 9.58 ACP5 MMP9 TNFSF11
7 homeostasis of number of cells within a tissue GO:0048873 9.55 CSF1 PTPN11
8 response to gamma radiation GO:0010332 9.54 PTPRC TP53
9 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.52 MMP9 TP53
10 bone resorption GO:0045453 9.51 ACP5 TNFSF11
11 positive regulation of osteoclast differentiation GO:0045672 9.48 CSF1 TNFSF11
12 macrophage differentiation GO:0030225 9.33 CSF1 CSF1R MMP9
13 macrophage colony-stimulating factor signaling pathway GO:0038145 9.32 CSF1 CSF1R
14 osteoclast proliferation GO:0002158 9.26 CSF1 TNFSF11
15 osteoclast differentiation GO:0030316 9.26 CALCR CSF1 CSF1R TNFSF11
16 cytokine-mediated signaling pathway GO:0019221 9.1 CSF1 CSF1R MMP9 PTPN11 TNFSF11 TP53

Sources for Pigmented Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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