MCID: PLR003
MIFTS: 26

Pilar Sheath Acanthoma

Categories: Cancer diseases

Aliases & Classifications for Pilar Sheath Acanthoma

MalaCards integrated aliases for Pilar Sheath Acanthoma:

Name: Pilar Sheath Acanthoma 12 15 17
Acanthoma, Pilar Sheath 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4322
MeSH 44 D049309
NCIt 50 C4468
SNOMED-CT 67 254693008
UMLS 70 C0346005

Summaries for Pilar Sheath Acanthoma

MalaCards based summary : Pilar Sheath Acanthoma, also known as acanthoma, pilar sheath, is related to acanthoma and basal cell carcinoma. An important gene associated with Pilar Sheath Acanthoma is TCHH (Trichohyalin), and among its related pathways/superpathways are Keratinization and Tight junction.

Wikipedia : 73 A pilar sheath acanthoma is a cutaneous condition most often found on the face, particularly above the... more...

Related Diseases for Pilar Sheath Acanthoma

Diseases related to Pilar Sheath Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 acanthoma 30.8 TCHH KRT5 CD1E CD1C CD1B CD1A
2 basal cell carcinoma 29.0 TCHH PHLDA1 MME KRT7 KRT5 KRT15
3 clear cell acanthoma 10.7
4 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.5
5 morpheaform basal cell carcinoma 10.4 PHLDA1 KRT15
6 predominantly cortical thymoma 10.4 CD1E CD1A
7 tolosa-hunt syndrome 10.4 CD1E CD1A
8 epidermal appendage tumor 10.4 PHLDA1 CYLD
9 dendritic cell thymoma 10.3 CD1E CD1A
10 cervical carcinosarcoma 10.3 MME CALB2
11 multifocal motor neuropathy 10.3 CD1E CD1A
12 malignant epithelial mesothelioma 10.3 PTGER4 CALB2
13 inverted follicular keratosis 10.3 PTGER4 PHLDA1
14 skin sarcoidosis 10.3 CD1C CD1B
15 papillary thymic adenocarcinoma 10.3 PTGER4 CALB2
16 breast adenomyoepithelioma 10.3 KRT5 ACIN1
17 spindle cell thymoma 10.3 KRT5 CALB2
18 lymphohistiocytoid mesothelioma 10.3 PTGER4 CALB2
19 oral hairy leukoplakia 10.3 CD1E CD1A
20 breast myoepithelial neoplasm 10.3 KRT5 ACIN1
21 ovarian endometrioid stromal sarcoma 10.3 MME CALB2
22 mixed type thymoma 10.3 CD1E CD1B CD1A
23 encapsulated thymoma 10.3 CD1E CD1B CD1A
24 sphenoid sinusitis 10.3 CD1E CD1B CD1A
25 epithelial malignant thymoma 10.3 CD1E CD1B CD1A
26 kidney hemangiopericytoma 10.3 CD34 CALB2
27 necrobiosis lipoidica 10.3 CD1E CD1B CD1A
28 bartholin's gland disease 10.3 KRT7 CALB2
29 benign fibrous mesothelioma 10.3 CD34 CALB2
30 peritoneal benign neoplasm 10.3 CD34 CALB2
31 adenoid basal cell carcinoma 10.2 TCHH KRT7
32 malignant biphasic mesothelioma 10.2 KRT5 CALB2
33 granulomatous dermatitis 10.2 CD1E CD1C CD1B
34 cervical adenoid cystic carcinoma 10.2 KRT7 CD1C
35 lung sarcoma 10.2 CD34 CALB2
36 erythema elevatum diutinum 10.2 CD34 CD1E
37 cervix erosion 10.2 MME KRT5
38 gummatous syphilis 10.2 TCHH ELN
39 ovarian germ cell teratoma 10.2 KRT7 CALB2
40 keratoacanthoma 10.2
41 trichofolliculoma 10.2
42 hair follicle neoplasm 10.2 TCHH KRT5 KRT15
43 sarcomatoid basal cell carcinoma 10.2 PTGER4 KRT5
44 stomach carcinoma in situ 10.2 KRT5 CYLD
45 ovarian serous adenofibroma 10.2 KRT7 CALB2
46 breast leiomyoma 10.2 MME CD34
47 pityriasis rosea 10.2 CD1E CD1A
48 breast myofibroblastoma 10.2 MME CD34
49 nephrogenic adenoma of urinary bladder 10.2 MME KRT7
50 cervical mucinous adenocarcinoma 10.2 MME KRT7

Graphical network of the top 20 diseases related to Pilar Sheath Acanthoma:



Diseases related to Pilar Sheath Acanthoma

Symptoms & Phenotypes for Pilar Sheath Acanthoma

Drugs & Therapeutics for Pilar Sheath Acanthoma

Search Clinical Trials , NIH Clinical Center for Pilar Sheath Acanthoma

Genetic Tests for Pilar Sheath Acanthoma

Anatomical Context for Pilar Sheath Acanthoma

Publications for Pilar Sheath Acanthoma

Articles related to Pilar Sheath Acanthoma:

(show all 18)
# Title Authors PMID Year
1
Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. 61
30839347 2019
2
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. 61
28609346 2018
3
Benign follicular tumors. 61
26734858 2015
4
An Unusual Location of a Pilar Sheath Acanthoma. 61
26903749 2015
5
Pilar Sheath Acanthoma Presenting as a Nevus. 61
26903752 2015
6
An unusual location of a pilar sheath acanthoma. 61
25368479 2014
7
Pilar sheath acanthoma simulating basal cell carcinoma. 61
24566580 2014
8
Postauricular pilar sheath acanthoma. 61
21769237 2011
9
Pilar sheath acanthoma--report of a case with review of the literature. 61
2697113 1989
10
Pilar sheath acanthoma. 61
3579335 1987
11
[Pilar sheath acanthoma]. 61
3557980 1987
12
Nevus comedonicus in association with widespread, well-differentiated follicular tumors. 61
3771864 1986
13
[Giant pore and hair-shaft acanthoma. Clinical and histologic diagnosis]. 61
6862884 1983
14
[ Pilar sheath acanthoma - a benign follicular hamartoma]. 61
6662259 1983
15
[The infundibular adenoma: a follicular poroma with sebaceous and apocrine differentiation (author's transl)]. 61
7235505 1981
16
Sebaceous trichofolliculoma. 61
7451702 1980
17
Pilar sheath acanthoma. A new benign follicular tumor. 61
521535 1979
18
Pilar sheath acanthoma. 61
718186 1978

Variations for Pilar Sheath Acanthoma

Expression for Pilar Sheath Acanthoma

Search GEO for disease gene expression data for Pilar Sheath Acanthoma.

Pathways for Pilar Sheath Acanthoma

Pathways related to Pilar Sheath Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.12 TCHH KRT7 KRT5 KRT15
2 11.95 CD1E CD1D CD1C CD1B CD1A
3 11.79 CD34 CD1D CD1C CD1B CD1A
4 11.56 CD1E CD1D CD1C CD1B CD1A
5 11.22 MME CD34 CD1D CD1C CD1A
6 11.16 MME CD34 CD1E CD1D CD1C CD1B

GO Terms for Pilar Sheath Acanthoma

Cellular components related to Pilar Sheath Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 MME GJA1 CD34 CD1E CD1D CD1C
2 endosome GO:0005768 9.63 GJA1 CD1E CD1D CD1C CD1B CD1A
3 endosome membrane GO:0010008 9.62 CD1D CD1C CD1B CD1A
4 external side of plasma membrane GO:0009897 9.43 CD34 CD1E CD1D CD1C CD1B CD1A
5 lysosome GO:0005764 9.17 GJA1 FLCN CD34 CD1E CD1D CD1C

Biological processes related to Pilar Sheath Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.93 CYLD CD1E CD1D CD1C CD1B CD1A
2 immune response GO:0006955 9.8 PTGER4 CD1E CD1D CD1C CD1B CD1A
3 keratinization GO:0031424 9.73 TCHH KRT7 KRT5 KRT15
4 cornification GO:0070268 9.67 TCHH KRT7 KRT5 KRT15
5 cellular response to mechanical stimulus GO:0071260 9.65 TNFRSF8 PTGER4 GJA1
6 regulation of immune response GO:0050776 9.65 CD34 CD1D CD1C CD1B CD1A
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
8 endothelium development GO:0003158 9.4 GJA1 CD34
9 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
10 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Pilar Sheath Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Pilar Sheath Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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