MCID: PLC011
MIFTS: 53

Pilocytic Astrocytoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pilocytic Astrocytoma

MalaCards integrated aliases for Pilocytic Astrocytoma:

Name: Pilocytic Astrocytoma 53 59 29 55 6 73
Juvenile Pilocytic Astrocytoma 53 73

Characteristics:

Orphanet epidemiological data:

59
pilocytic astrocytoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA251612
ICD10 via Orphanet 34 C71.9
UMLS via Orphanet 74 C0334583

Summaries for Pilocytic Astrocytoma

NIH Rare Diseases : 53 Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. The tumor may be in the form of a cyst and usually does not spread to nearby tissues. Symptoms vary depending upon the size and location of the tumor. Most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. The underlying cause of a pilocytic astrocytoma is unknown. It most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome, and tuberous sclerosis. This type of tumor can often be cured with surgery.

MalaCards based summary : Pilocytic Astrocytoma, also known as juvenile pilocytic astrocytoma, is related to pilocytic astrocytoma of cerebellum and juvenile pilocytic astrocytoma, and has symptoms including headache An important gene associated with Pilocytic Astrocytoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are ERK Signaling and Development VEGF signaling via VEGFR2 - generic cascades. The drugs Procarbazine and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related phenotypes are Decreased viability in esophageal squamous lineage and Increased cell migration

Wikipedia : 76 Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its... more...

Related Diseases for Pilocytic Astrocytoma

Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma of cerebellum 33.5 BRAF IDH1 KIAA1549 NF1
2 juvenile pilocytic astrocytoma 33.5 GFAP NF1 TIMP3
3 glioma 30.5 BRAF IDH1 NF1
4 dysembryoplastic neuroepithelial tumor 30.4 GFAP IDH1
5 glioma susceptibility 1 30.3 GFAP IDH1
6 ganglioglioma 30.2 BRAF GFAP
7 oligodendroglioma 30.1 GFAP IDH1 SOX10
8 ependymoma 30.0 GFAP TIMP3
9 gliofibroma 30.0 GFAP NF1
10 pleomorphic xanthoastrocytoma 30.0 BRAF GFAP IDH1
11 obstructive hydrocephalus 29.9 GFAP NF1
12 noonan syndrome 1 29.9 BRAF KRAS NF1
13 pilomyxoid astrocytoma 29.9 BRAF GFAP KIAA1549 KRAS NF1
14 childhood pilocytic astrocytoma 12.5
15 astrocytoma 11.3
16 neurofibromatosis, type i 10.5
17 glioblastoma 10.5
18 medulloblastoma 10.4
19 glioblastoma multiforme 10.3
20 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
21 hyperplastic polyposis syndrome 10.2 BRAF KRAS
22 mature teratoma 10.2 BRAF KRAS
23 colonic benign neoplasm 10.1 BRAF KRAS
24 autism 10.1
25 encephalocraniocutaneous lipomatosis 10.1
26 hydrocephalus 10.1
27 leukemia 10.1
28 autism spectrum disorder 10.1
29 siderosis 10.1
30 lipomatosis 10.1
31 craniopharyngioma 10.1
32 mutism 10.1
33 hemangioblastoma 10.1
34 diencephalic syndrome 10.1
35 tremor 10.1
36 hemifacial spasm 10.1
37 pituicytoma 10.1
38 villous adenoma 10.1 BRAF KRAS
39 cerebellar astrocytoma 10.1 IDH1 KIAA1549
40 mucosal melanoma 10.1 BRAF NF1
41 leopard syndrome 10.1 BRAF NF1
42 neurofibroma 10.1 NF1 SOX10
43 adult oligodendroglioma 10.1 IDH1 NF1
44 malignant spindle cell melanoma 10.1 NF1 SOX10
45 undifferentiated pleomorphic sarcoma 10.1 IDH1 KRAS
46 spinal meningioma 10.1 NF1 SOX10
47 spinal canal and spinal cord meningioma 10.1 NF1 SOX10
48 intraneural perineurioma 10.0 NF1 SOX10
49 bile duct adenocarcinoma 10.0 IDH1 KRAS
50 cardiofaciocutaneous syndrome 1 10.0 BRAF KRAS

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma:



Diseases related to Pilocytic Astrocytoma

Symptoms & Phenotypes for Pilocytic Astrocytoma

UMLS symptoms related to Pilocytic Astrocytoma:


headache

GenomeRNAi Phenotypes related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.5 BRAF GFAP IDH1 KIAA1549 KRAS SOX10
2 Increased cell migration GR00055-A-3 8.8 BRAF KRAS NF1

MGI Mouse Phenotypes related to Pilocytic Astrocytoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.08 BRAF GFAP IDH1 KIAA1549 KRAS NF1
2 behavior/neurological MP:0005386 10.07 BRAF GFAP KIAA1549 KRAS NF1 SOX10
3 growth/size/body region MP:0005378 10.04 BRAF GFAP IDH1 KRAS NF1 SOX10
4 immune system MP:0005387 10 BRAF GFAP IDH1 KIAA1549 KRAS NF1
5 mortality/aging MP:0010768 9.95 BRAF GFAP IDH1 KRAS NF1 SOX10
6 digestive/alimentary MP:0005381 9.91 BRAF GFAP KRAS NF1 SOX10
7 integument MP:0010771 9.83 BRAF KRAS NF1 SOX10 TIMP3
8 muscle MP:0005369 9.77 BRAF GFAP KRAS NF1 TIMP3
9 normal MP:0002873 9.65 BRAF GFAP KRAS NF1 SOX10
10 neoplasm MP:0002006 9.62 BRAF KRAS NF1 SOX10
11 pigmentation MP:0001186 9.55 BRAF KRAS NF1 SOX10 TIMP3
12 respiratory system MP:0005388 9.43 BRAF IDH1 KRAS NF1 SOX10 TIMP3
13 vision/eye MP:0005391 9.02 BRAF GFAP KRAS NF1 TIMP3

Drugs & Therapeutics for Pilocytic Astrocytoma

Drugs for Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 157)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procarbazine Approved, Investigational Phase 2, Phase 3 671-16-9 4915
2
Vincristine Approved, Investigational Phase 2, Phase 3,Phase 1 57-22-7, 2068-78-2 5978
3
Lomustine Approved, Investigational Phase 2, Phase 3 13010-47-4 3950
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
5
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
6
Dopamine Approved Phase 3,Early Phase 1,Not Applicable 51-61-6, 62-31-7 681
7
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
8
Cyproheptadine Approved Phase 3 129-03-3 2913
9
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
10 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
11 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 1
12 Alkylating Agents Phase 2, Phase 3,Phase 1
13 Dermatologic Agents Phase 3,Phase 2,Phase 1
14 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 1
15 Antimitotic Agents Phase 2, Phase 3,Phase 1
16 Cola Phase 3,Phase 1
17 Central Nervous System Depressants Phase 3
18 Adjuvants, Anesthesia Phase 3
19 Liver Extracts Phase 3,Phase 2,Phase 1
20 Anesthetics, Intravenous Phase 3
21 Analgesics, Opioid Phase 3
22 Peripheral Nervous System Agents Phase 3
23 Anesthetics, General Phase 3
24 Analgesics Phase 3
25 Narcotics Phase 3
26 Anesthetics Phase 3
27 Neurotransmitter Agents Phase 3,Phase 2,Early Phase 1,Not Applicable
28 Nootropic Agents Phase 3,Phase 2
29 Cholinergic Agents Phase 3,Phase 2
30 Cholinesterase Inhibitors Phase 3,Phase 2
31 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
32 Central Nervous System Stimulants Phase 3,Phase 2
33 Dopamine Agents Phase 3,Early Phase 1,Not Applicable
34 Serotonin Agents Phase 3
35 Anti-Allergic Agents Phase 3
36 Serotonin Antagonists Phase 3
37 Histamine H1 Antagonists Phase 3
38
Histamine Phosphate Phase 3 51-74-1 65513
39 Antipruritics Phase 3
40 Histamine Antagonists Phase 3
41 Dexmethylphenidate Hydrochloride Phase 3
42 Neurotransmitter Uptake Inhibitors Phase 3
43 Dopamine Uptake Inhibitors Phase 3
44
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
45
Dacarbazine Approved, Investigational Phase 2,Phase 1 4342-03-4 5351166
46
Temozolomide Approved, Investigational Phase 2,Phase 1 85622-93-1 5394
47
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
48
Trioxsalen Approved Phase 2,Phase 1 3902-71-4 5585
49
Sirolimus Approved, Investigational Phase 1, Phase 2,Phase 2 53123-88-9 46835353 6436030 5284616
50
Everolimus Approved Phase 1, Phase 2,Phase 2 159351-69-6 6442177

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma Completed NCT00003375 Phase 2, Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
6 Bevacizumab in Recurrent Grade II and III Glioma Unknown status NCT01164189 Phase 2 Temozolomide
7 Temozolomide in Treating Patients With Low-Grade Glioma Completed NCT00313729 Phase 2 temozolomide
8 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2 erlotinib;temsirolimus
9 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
10 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
11 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
12 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
13 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
14 Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas Completed NCT00274755 Phase 2 chemotherapy
15 Imatinib Mesylate in Treating Patients With Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
16 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2 gefitinib
17 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
18 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
19 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2 imatinib mesylate
20 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
21 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
22 Antineoplaston Therapy in Treating Children With Brain Tumors Completed NCT00003458 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
23 Phase II Pegylated Interferon Recruiting NCT02343224 Phase 2 Pegylated interferon alpha-2b
24 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
25 Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Recruiting NCT01089101 Phase 1, Phase 2 Selumetinib
26 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib;Carboplatin with vincristine
27 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Active, not recruiting NCT01553149 Phase 2 Lenalidomide
28 Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Active, not recruiting NCT01966809 Phase 2 Photofrin photodynamic therapy.
29 Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Active, not recruiting NCT00553150 Phase 1, Phase 2 everolimus;temozolomide
30 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
31 Functional Magnetic Resonance Imaging and 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Treating Patients With Newly Diagnosed Brain Tumors Withdrawn NCT00005083 Phase 2
32 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
33 Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas Unknown status NCT00083096 Phase 1 lonafarnib;temozolomide
34 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
35 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
36 Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma Completed NCT00730613 Phase 1
37 Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers Completed NCT00498979 Phase 1 cisplatin;sodium stibogluconate;dacarbazine;vinblastine
38 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
39 Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00509431 Phase 1 Erlotinib + Sirolimus
40 Tumor Tissue Analysis in Patients Receiving Imatinib Mesylate for Malignant Glioma Completed NCT00401024 Phase 1 imatinib mesylate
41 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
42 BCX-1777 in Treating Patients With Refractory Cancer Completed NCT00073944 Phase 1 forodesine hydrochloride
43 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
44 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
45 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
46 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
47 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
48 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
49 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
50 Cognitive Biomarkers in Pediatric Brain Tumor Patients Recruiting NCT02914067 Phase 1

Search NIH Clinical Center for Pilocytic Astrocytoma

Genetic Tests for Pilocytic Astrocytoma

Genetic tests related to Pilocytic Astrocytoma:

# Genetic test Affiliating Genes
1 Pilocytic Astrocytoma 29

Anatomical Context for Pilocytic Astrocytoma

MalaCards organs/tissues related to Pilocytic Astrocytoma:

41
Brain, Spinal Cord, Cerebellum, T Cells, Bone, Pineal, Eye

Publications for Pilocytic Astrocytoma

Articles related to Pilocytic Astrocytoma:

(show top 50) (show all 423)
# Title Authors Year
1
Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children. ( 29125440 )
2018
2
Supratentorial extension of large cerebellar pilocytic astrocytoma in adult. ( 29446978 )
2018
3
Reader response: Pilocytic astrocytoma with anaplasia arising from the optic chiasm in a very elderly patient. ( 29807920 )
2018
4
Durable response to bevacizumab in adults with recurrent pilocytic astrocytoma. ( 29629823 )
2018
5
Management and survival of adult patients with pilocytic astrocytoma in the National Cancer Database. ( 29427814 )
2018
6
Long-Term Remission of Recurrent Brainstem Pilocytic Astrocytoma with Neuraxis Dissemination Using Recombinant Human Endostatin After Failure of Vincristine and Carboplatin. ( 29203315 )
2018
7
Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence. ( 29180079 )
2018
8
Pilocytic astrocytoma with leptomeningeal spread in a patient with incontinentia pigmenti presenting with unilateral nystagmus. ( 29171168 )
2018
9
An elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component in the cerebellar hemisphere. ( 29851180 )
2018
10
CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma. ( 29804288 )
2018
11
Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma. ( 29797290 )
2018
12
Pilocytic astrocytoma with spontaneous malignant transformation with intracranial and skeletal dissemination: case report and review of the literature. ( 29745267 )
2018
13
Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report. ( 29768357 )
2018
14
Rare compound heterozygous variants in PNKP identified by whole exome sequencing in a German patient with ataxia-oculomotor apraxia 4 and pilocytic astrocytoma. ( 29498415 )
2018
15
Pediatric cerebellar pilocytic astrocytoma presenting with spontaneous intratumoral hemorrhage. ( 29569086 )
2018
16
Simultaneous supratentorial and infratentorial pilocytic astrocytoma in an adult patient with concurrent neurofibromatosis type 1 and HIV infection. ( 29908379 )
2018
17
Mitogen-activated protein kinase in gliosis and pilocytic astrocytoma. ( 29168690 )
2018
18
<i>FGFR1</i> tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia. ( 29610389 )
2018
19
Delayed leptomeningeal metastasis of an adult anaplastic pilocytic astrocytoma. ( 29330645 )
2018
20
Editors' note: Pilocytic astrocytoma with anaplasia arising from the optic chiasm in a very elderly patient. ( 29807919 )
2018
21
Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma. ( 29804214 )
2018
22
Lacunar Stroke, Cavernous Angioma, and Fusiform Aneurysm Due to Irradiation for Pilocytic Astrocytoma-A Case Report. ( 29673614 )
2018
23
Intraorbital ancient pilocytic astrocytoma of the optic nerve in neurofibromatosis type 1 patient presenting with sudden ocular pain. ( 29511546 )
2018
24
Orbital tumor associated with a microphthalmic eye and colobomatous cleft: Pilocytic astrocytoma (glioma) or massive retinal gliosis. ( 29755278 )
2018
25
Circulating serum oncologic miRNA in pediatric juvenile pilocytic astrocytoma patients predicts mural nodule volume. ( 29911246 )
2018
26
Pilocytic Astrocytoma with Adipocytic Differentiation: A Rare Histological Variation. ( 30090152 )
2018
27
An elderly patient presenting with a primary spinal multifocal intradural extramedullary pilocytic astrocytoma: a case report and review of the literature. ( 30092761 )
2018
28
Multilineage ACTB mutation in a patient with fibro-osseous maxillary lesion and pilocytic astrocytoma. ( 30152002 )
2018
29
Use of Apparent Diffusion Coefficient Histogram in Differentiating Between Medulloblastoma and Pilocytic Astrocytoma in Children. ( 30173245 )
2018
30
Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia. ( 30192422 )
2018
31
Clinical Significance of T2*gradient-recalled Echo/susceptibility-weighted Imaging Sequences in Evaluating Superficial Siderosis in the Setting of Intracerebral Tumors: Pilocytic Astrocytoma. ( 30197827 )
2018
32
Leptomeningeal dissemination of spinal pilocytic astrocytoma: a rare entity. ( 30269096 )
2018
33
Endoscopic transnasal resection of optic pathway pilocytic astrocytoma. ( 30338361 )
2018
34
Solid non-enhancing cerebellar pilocytic astrocytoma case report. ( 30366781 )
2018
35
"Integrated diagnosis" of pilocytic astrocytoma: Molecular diagnostic procedure for an unusual case. ( 30417961 )
2018
36
Differentiation between pilocytic astrocytoma and glioblastoma: a decision tree model using contrast-enhanced magnetic resonance imaging-derived quantitative radiomic features. ( 30421019 )
2018
37
Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior. ( 30428478 )
2018
38
Pilocytic Astrocytoma with Gangliocytic Differentiation to Pilomyxoid Astrocytoma-expanding the Morphological Spectrum: Case Report and Literature Review. ( 30459892 )
2018
39
ATRX protein loss and deregulation of PI3K/AKT pathway is frequent in pilocytic astrocytoma with anaplastic features. ( 30499772 )
2018
40
Mathematical skills in children with pilocytic astrocytoma. ( 30523458 )
2018
41
The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma. ( 30530705 )
2018
42
Author response: Pilocytic astrocytoma with anaplasia arising from the optic chiasm in a very elderly patient. ( 29807921 )
2018
43
Longitudinal mutational analysis of a cerebellar pilocytic astrocytoma recurring as a ganglioglioma. ( 27718322 )
2017
44
Pilocytic astrocytoma mimicking cavernous angioma: Imaging features and histological characteristics. ( 28919136 )
2017
45
Pilocytic astrocytoma of the cerebellopontine angle mimicking vestibular schwannoma: report of a rare entity. ( 29278012 )
2017
46
Pilocytic astrocytoma: A rare presentation as intraventricular tumor. ( 28680735 )
2017
47
Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy. ( 28137267 )
2017
48
Brainstem pilocytic astrocytoma with H3 K27M mutation: case report. ( 28960151 )
2017
49
Pilocytic Astrocytoma Enlargement Following Irradiation: Relapse or Pseudoprogression? ( 28367384 )
2017
50
Evaluation of outcomes after stereotactic radiosurgery for pilocytic astrocytoma. ( 28567590 )
2017

Variations for Pilocytic Astrocytoma

ClinVar genetic disease variations for Pilocytic Astrocytoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 KRAS NM_033360.3(KRAS): c.37G> C (p.Gly13Arg) single nucleotide variant Pathogenic rs121913535 GRCh37 Chromosome 12, 25398282: 25398282
2 KRAS NM_033360.3(KRAS): c.37G> C (p.Gly13Arg) single nucleotide variant Pathogenic rs121913535 GRCh38 Chromosome 12, 25245348: 25245348

Copy number variations for Pilocytic Astrocytoma from CNVD:

7 (show all 22)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 38161 10 1 3000000 Gain DIP2C Pilocytic astrocytoma
2 40599 10 130600000 135534747 Loss DRD1IP Pilocytic astrocytoma
3 64537 12 129300000 133851895 Loss BCL7A Pilocytic astrocytoma
4 84233 14 24600000 33300000 Loss FOXG1B Pilocytic astrocytoma
5 97079 15 98500000 102531392 Loss LASS3 Pilocytic astrocytoma
6 112680 17 40811265 40819024 Loss TUBG2 Pilocytic astrocytoma
7 112684 17 40834631 40852011 Loss CNTNAP1 Pilocytic astrocytoma
8 220399 7 138200000 143100000 Amplification Pilocytic astrocytoma
9 227901 7 72200000 77500000 Loss BCL7B Pilocytic astrocytoma
10 230764 8 1 2200000 Loss Pilocytic astrocytoma
11 234563 8 136400000 146364022 Gain COL22A1 Pilocytic astrocytoma
12 234873 8 139900000 146364022 Gain CYHR1 Pilocytic astrocytoma
13 234878 8 139900000 146364022 Gain FOXH1 Pilocytic astrocytoma
14 234881 8 139900000 146364022 Gain GPT Pilocytic astrocytoma
15 234884 8 139900000 146364022 Gain KIFC2 Pilocytic astrocytoma
16 234886 8 139900000 146364022 Gain LRRC14 Pilocytic astrocytoma
17 234888 8 139900000 146364022 Gain LRRC24 Pilocytic astrocytoma
18 234890 8 139900000 146364022 Gain MFSD3 Pilocytic astrocytoma
19 234893 8 139900000 146364022 Gain PPP1R16A Pilocytic astrocytoma
20 234897 8 139900000 146364022 Gain RECQL4 Pilocytic astrocytoma
21 244900 9 1 2200000 Loss ANKRD15 Pilocytic astrocytoma
22 256191 9 9000000 28000000 Loss SH3GL2 Pilocytic astrocytoma

Expression for Pilocytic Astrocytoma

Search GEO for disease gene expression data for Pilocytic Astrocytoma.

Pathways for Pilocytic Astrocytoma

Pathways related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 BRAF GFAP KRAS NF1 SOX10 TIMP3
2
Show member pathways
12.02 BRAF KRAS NF1
3
Show member pathways
11.86 BRAF KRAS TIMP3
4
Show member pathways
11.85 BRAF KRAS NF1
5 11.8 BRAF KRAS TIMP3
6 11.62 BRAF KRAS NF1
7 11.39 BRAF KRAS TIMP3
8 11.38 BRAF KRAS NF1
9 11.33 BRAF KRAS
10 11.22 KRAS NF1
11 11.18 BRAF KRAS NF1
12 11.13 BRAF KRAS
13
Show member pathways
11.06 BRAF KIAA1549 KRAS NF1
14 11.01 BRAF KRAS
15 10.84 BRAF KRAS

GO Terms for Pilocytic Astrocytoma

Biological processes related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.54 BRAF KRAS NF1
2 long-term synaptic potentiation GO:0060291 9.4 BRAF GFAP
3 peripheral nervous system development GO:0007422 9.32 NF1 SOX10
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 KRAS NF1
5 regulation of synaptic transmission, GABAergic GO:0032228 9.16 KRAS NF1
6 visual learning GO:0008542 9.13 BRAF KRAS NF1
7 forebrain astrocyte development GO:0021897 8.62 KRAS NF1

Sources for Pilocytic Astrocytoma

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