MCID: PLC004
MIFTS: 31

Pilocytic Astrocytoma of Cerebellum

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Pilocytic Astrocytoma of Cerebellum

MalaCards integrated aliases for Pilocytic Astrocytoma of Cerebellum:

Name: Pilocytic Astrocytoma of Cerebellum 12 15 73
Cerebellar Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4853
NCIt 50 C6809
SNOMED-CT 68 277507004
UMLS 73 C0349620

Summaries for Pilocytic Astrocytoma of Cerebellum

MalaCards based summary : Pilocytic Astrocytoma of Cerebellum, also known as cerebellar pilocytic astrocytoma, is related to pilocytic astrocytoma and childhood oligodendroglioma, and has symptoms including headache and nausea and vomiting. An important gene associated with Pilocytic Astrocytoma of Cerebellum is PNKP (Polynucleotide Kinase 3'-Phosphatase), and among its related pathways/superpathways are HIV Life Cycle and Glioma. Affiliated tissues include cerebellum, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pilocytic Astrocytoma of Cerebellum

Diseases related to Pilocytic Astrocytoma of Cerebellum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 29.4 BRAF IDH1 KIAA1549 NF1
2 childhood oligodendroglioma 10.6 IDH1 KIAA1549
3 interval angle-closure glaucoma 10.5 IDH1 IDH2
4 enchondroma 10.5 IDH1 IDH2
5 intracranial chondrosarcoma 10.5 IDH1 IDH2
6 cytogenetically normal acute myeloid leukemia 10.5 IDH1 IDH2
7 chondroblastic osteosarcoma 10.5 IDH1 IDH2
8 intraductal papilloma 10.5 IDH1 IDH2
9 pleomorphic xanthoastrocytoma 10.5 BRAF IDH1
10 spindle cell hemangioma 10.4 IDH1 IDH2
11 glioma susceptibility 1 10.4 IDH1 IDH2
12 periosteal chondrosarcoma 10.4 IDH1 IDH2
13 adult astrocytic tumour 10.4 IDH1 IDH2
14 undifferentiated pleomorphic sarcoma 10.4 IDH1 IDH2
15 drug-induced mental disorder 10.4 IDH1 IDH2
16 drug psychosis 10.4 IDH1 IDH2
17 diffuse infiltrative lymphocytosis syndrome 10.3 IDH1 IDH2
18 2-hydroxyglutaric aciduria 10.3 IDH1 IDH2
19 childhood pilocytic astrocytoma 10.3 KIAA1549 NF1
20 breast papillary carcinoma 10.3 IDH1 IDH2
21 d-2-hydroxyglutaric aciduria 1 10.3 IDH1 IDH2
22 villous adenoma 10.3 BRAF GNAS
23 enchondromatosis, multiple, ollier type 10.2 IDH1 IDH2
24 peripheral osteosarcoma 10.2 GNAS IDH1
25 astrocytoma 10.1
26 bile duct adenocarcinoma 10.1 IDH1 IDH2
27 mucosal melanoma 10.1 BRAF NF1
28 fibrillary astrocytoma 10.1 IDH1 IDH2 KIAA1549
29 leopard syndrome 10.1 BRAF NF1
30 pulmonic stenosis 10.0 BRAF NF1
31 brain stem glioma 10.0 BRAF IDH1 IDH2
32 myeloma, multiple 9.9 BRAF IDH1 IDH2
33 multiple enchondromatosis, maffucci type 9.9 GNAS IDH1 IDH2
34 cerebellar astrocytoma 9.9 IDH1 KIAA1549 MARK3 PNKP
35 brain cancer 9.9 BRAF IDH1 IDH2
36 adult oligodendroglioma 9.8 IDH1 IDH2 NF1
37 osteofibrous dysplasia 9.8 GNAS NF1
38 giant cell glioblastoma 9.7 BRAF IDH1
39 squamous cell carcinoma, head and neck 9.5 BRAF GNAS IDH2
40 lung cancer susceptibility 3 9.4 BRAF GNAS IDH1
41 spinal cord ependymoma 9.3 MAPK3 NF1
42 glioma 9.3 BRAF IDH1 IDH2 NF1
43 glioblastoma 9.0 BRAF IDH1 IDH2 MAPK3
44 colorectal cancer 7.0 BRAF GNAS IDH1 IDH2 MAPK3 NF1

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma of Cerebellum:



Diseases related to Pilocytic Astrocytoma of Cerebellum

Symptoms & Phenotypes for Pilocytic Astrocytoma of Cerebellum

UMLS symptoms related to Pilocytic Astrocytoma of Cerebellum:


headache, nausea and vomiting

GenomeRNAi Phenotypes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.86 BRAF MARK3
2 Decreased viability GR00221-A-1 9.86 MARK3 NF1
3 Decreased viability GR00221-A-2 9.86 MARK3 NF1
4 Decreased viability GR00221-A-4 9.86 BRAF MAPK3 MARK3 NF1
5 Decreased viability GR00301-A 9.86 BRAF
6 Decreased viability GR00381-A-1 9.86 BRAF
7 Decreased viability GR00402-S-2 9.86 BRAF MAPK3 MARK3 NF1
8 Decreased cell migration GR00055-A-1 9.46 BRAF MAPK3 MARK3 NF1
9 Increased cell migration GR00055-A-3 8.92 BRAF MAPK3 MARK3 NF1

MGI Mouse Phenotypes related to Pilocytic Astrocytoma of Cerebellum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.86 MARK3 NF1 PNKP BRAF GNAS IDH1
2 liver/biliary system MP:0005370 9.55 MARK3 NF1 BRAF GNAS MAPK3
3 neoplasm MP:0002006 9.35 NF1 BRAF GNAS IDH2 MAPK3
4 respiratory system MP:0005388 9.02 MAPK3 NF1 BRAF GNAS IDH1

Drugs & Therapeutics for Pilocytic Astrocytoma of Cerebellum

Search Clinical Trials , NIH Clinical Center for Pilocytic Astrocytoma of Cerebellum

Genetic Tests for Pilocytic Astrocytoma of Cerebellum

Anatomical Context for Pilocytic Astrocytoma of Cerebellum

MalaCards organs/tissues related to Pilocytic Astrocytoma of Cerebellum:

41
Cerebellum

Publications for Pilocytic Astrocytoma of Cerebellum

Articles related to Pilocytic Astrocytoma of Cerebellum:

# Title Authors Year
1
Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. ( 28503586 )
2015
2
Spontaneous anaplasia in pilocytic astrocytoma of cerebellum. ( 14565523 )
2003

Variations for Pilocytic Astrocytoma of Cerebellum

Expression for Pilocytic Astrocytoma of Cerebellum

Search GEO for disease gene expression data for Pilocytic Astrocytoma of Cerebellum.

Pathways for Pilocytic Astrocytoma of Cerebellum

Pathways related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 BRAF IDH1 KIAA1549 MAPK3 MARK3 NF1
2
Show member pathways
12.53 BRAF GNAS MAPK3 NF1
3
Show member pathways
12.49 BRAF GNAS MAPK3 NF1
4
Show member pathways
12.19 BRAF MAPK3 NF1
5
Show member pathways
12.15 BRAF GNAS MAPK3
6
Show member pathways
12.07 BRAF GNAS MAPK3
7
Show member pathways
11.97 BRAF GNAS MAPK3
8 11.96 BRAF GNAS MAPK3
9
Show member pathways
11.81 BRAF GNAS MAPK3
10
Show member pathways
11.76 BRAF MAPK3 MARK3 NF1
11 11.74 BRAF MAPK3 NF1
12 11.72 BRAF GNAS MAPK3
13 11.7 BRAF MAPK3 NF1
14 11.66 BRAF GNAS MAPK3
15 11.55 BRAF GNAS MAPK3
16 11.38 BRAF GNAS MAPK3
17
Show member pathways
11.34 BRAF MAPK3 NF1
18
Show member pathways
11.31 BRAF MAPK3 MARK3
19 11.25 BRAF MAPK3
20 11.21 BRAF GNAS MAPK3
21
Show member pathways
11.15 BRAF KIAA1549 MAPK3 MARK3 NF1
22 11.12 MAPK3 NF1
23
Show member pathways
11.09 BRAF MAPK3
24 10.95 BRAF GNAS
25
Show member pathways
10.64 IDH1 IDH2
26 10.41 BRAF GNAS MAPK3

GO Terms for Pilocytic Astrocytoma of Cerebellum

Biological processes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.8 BRAF MAPK3 MARK3 PNKP
2 visual learning GO:0008542 9.54 BRAF NF1
3 thymus development GO:0048538 9.52 BRAF MAPK3
4 cognition GO:0050890 9.51 GNAS NF1
5 positive regulation of telomerase activity GO:0051973 9.48 MAPK3 PNKP
6 positive regulation of telomere maintenance via telomerase GO:0032212 9.46 MAPK3 PNKP
7 MAPK cascade GO:0000165 9.46 BRAF MAPK3 MARK3 NF1
8 tricarboxylic acid cycle GO:0006099 9.43 IDH1 IDH2
9 thyroid gland development GO:0030878 9.4 BRAF MAPK3
10 2-oxoglutarate metabolic process GO:0006103 9.37 IDH1 IDH2
11 face development GO:0060324 9.32 BRAF MAPK3
12 positive regulation of telomere capping GO:1904355 9.26 MAPK3 PNKP
13 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
14 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.56 BRAF MAPK3 MARK3 PNKP
2 NAD binding GO:0051287 9.32 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Pilocytic Astrocytoma of Cerebellum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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