Pilocytic Astrocytoma of Cerebellum disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLC004 MIFTS: 34	Pilocytic Astrocytoma of Cerebellum Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Pilocytic Astrocytoma of Cerebellum

MalaCards integrated aliases for Pilocytic Astrocytoma of Cerebellum:

Name: Pilocytic Astrocytoma of Cerebellum ¹² ¹⁵ ⁷³

Cerebellar Pilocytic Astrocytoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4853

NCIt ⁵⁰ C6809

UMLS ⁷³ C0349620

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Summaries for Pilocytic Astrocytoma of Cerebellum

MalaCards based summary : Pilocytic Astrocytoma of Cerebellum, also known as cerebellar pilocytic astrocytoma, is related to pleomorphic xanthoastrocytoma and pilocytic astrocytoma, and has symptoms including nausea and vomiting and headache. An important gene associated with Pilocytic Astrocytoma of Cerebellum is PNKP (Polynucleotide Kinase 3'-Phosphatase), and among its related pathways/superpathways are HIV Life Cycle and Glioma. Affiliated tissues include cerebellum, lung and brain, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Pilocytic Astrocytoma of Cerebellum

Diseases related to Pilocytic Astrocytoma of Cerebellum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)

#	Related Disease	Score	Top Affiliating Genes
1	pleomorphic xanthoastrocytoma	30.4	BRAF IDH1
2	pilocytic astrocytoma	30.2	BRAF IDH1 KIAA1549 NF1
3	glioblastoma	29.3	BRAF IDH1 IDH2 MAPK3 NF1
4	astrocytoma	10.3
5	ganglioglioma	10.2
6	childhood oligodendroglioma	10.2	IDH1 KIAA1549
7	enchondroma	10.1	IDH1 IDH2
8	interval angle-closure glaucoma	10.1	IDH1 IDH2
9	intracranial chondrosarcoma	10.1	IDH1 IDH2
10	cytogenetically normal acute myeloid leukemia	10.1	IDH1 IDH2
11	chondroblastic osteosarcoma	10.1	IDH1 IDH2
12	intraductal papilloma	10.1	IDH1 IDH2
13	spindle cell hemangioma	10.1	IDH1 IDH2
14	periosteal chondrosarcoma	10.1	IDH1 IDH2
15	glioma susceptibility 1	10.1	IDH1 IDH2
16	adult astrocytic tumour	10.1	IDH1 IDH2
17	diffuse infiltrative lymphocytosis syndrome	10.1	IDH1 IDH2
18	drug-induced mental disorder	10.1	IDH1 IDH2
19	drug psychosis	10.1	IDH1 IDH2
20	undifferentiated pleomorphic sarcoma	10.1	IDH1 IDH2
21	neurofibromatosis, type i	10.1
22	autism	10.1
23	thrombocytopenia	10.1
24	autism spectrum disorder	10.1
25	albright's hereditary osteodystrophy	10.1
26	meningitis	10.1
27	tremor	10.1
28	2-hydroxyglutaric aciduria	10.1	IDH1 IDH2
29	d-2-hydroxyglutaric aciduria 1	10.1	IDH1 IDH2
30	villous adenoma	10.1	BRAF GNAS
31	peripheral osteosarcoma	10.1	GNAS IDH1
32	bile duct adenocarcinoma	10.0	IDH1 IDH2
33	fibrillary astrocytoma	10.0	IDH1 IDH2 KIAA1549
34	enchondromatosis, multiple, ollier type	10.0	IDH1 IDH2
35	mucosal melanoma	10.0	BRAF NF1
36	leopard syndrome	10.0	BRAF NF1
37	pineal parenchymal tumor of intermediate differentiation	10.0	IDH1 NF1
38	brain stem glioma	10.0	BRAF IDH1 IDH2
39	cholangiocarcinoma	10.0	BRAF IDH1 IDH2
40	cerebellar astrocytoma	10.0	IDH1 KIAA1549 MARK3 PNKP
41	multiple enchondromatosis, maffucci type	10.0	GNAS IDH1 IDH2
42	myeloma, multiple	9.9	BRAF IDH1 IDH2
43	pilomyxoid astrocytoma	9.9	BRAF KIAA1549 NF1
44	adult oligodendroglioma	9.9	IDH1 IDH2 NF1
45	osteofibrous dysplasia	9.9	GNAS NF1
46	giant cell glioblastoma	9.9	BRAF IDH1
47	urachal adenocarcinoma	9.9	BRAF GNAS NF1
48	pulmonic stenosis	9.9	BRAF NF1
49	supratentorial cancer	9.8	IDH1 IDH2 KIAA1549 NF1
50	cerebrum cancer	9.8	IDH1 IDH2 KIAA1549 NF1

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma of Cerebellum:

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Symptoms & Phenotypes for Pilocytic Astrocytoma of Cerebellum

UMLS symptoms related to Pilocytic Astrocytoma of Cerebellum:

nausea and vomiting, headache

GenomeRNAi Phenotypes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.86	BRAF MARK3
2	Decreased viability	GR00221-A-1	9.86	MARK3 NF1
3	Decreased viability	GR00221-A-2	9.86	MARK3 NF1
4	Decreased viability	GR00221-A-4	9.86	BRAF MAPK3 MARK3 NF1
5	Decreased viability	GR00301-A	9.86	BRAF
6	Decreased viability	GR00381-A-1	9.86	BRAF
7	Decreased viability	GR00402-S-2	9.86	BRAF MAPK3 MARK3 NF1
8	Decreased cell migration	GR00055-A-1	9.46	BRAF MAPK3 MARK3 NF1
9	Increased cell migration	GR00055-A-3	8.92	BRAF MAPK3 MARK3 NF1

MGI Mouse Phenotypes related to Pilocytic Astrocytoma of Cerebellum:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.86	BRAF GNAS IDH1 KIAA1549 MAPK3 MARK3
2	liver/biliary system	MP:0005370	9.55	BRAF GNAS MAPK3 MARK3 NF1
3	neoplasm	MP:0002006	9.35	BRAF GNAS IDH2 MAPK3 NF1
4	respiratory system	MP:0005388	9.02	BRAF GNAS IDH1 MAPK3 NF1

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Drugs & Therapeutics for Pilocytic Astrocytoma of Cerebellum

Search Clinical Trials , NIH Clinical Center for Pilocytic Astrocytoma of Cerebellum

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Genetic Tests for Pilocytic Astrocytoma of Cerebellum

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Anatomical Context for Pilocytic Astrocytoma of Cerebellum

MalaCards organs/tissues related to Pilocytic Astrocytoma of Cerebellum:

⁴¹

Cerebellum, Lung, Brain, Pineal, Myeloid

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Publications for Pilocytic Astrocytoma of Cerebellum

Articles related to Pilocytic Astrocytoma of Cerebellum:

#	Title	Authors	Year
1	Solid non-enhancing cerebellar pilocytic astrocytoma case report. ( 30366781 )	Towner JE...Drummond K	2018
2	Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. ( 28503586 )	Coelho J....Salgado D.	2015
3	Spontaneous anaplasia in pilocytic astrocytoma of cerebellum. ( 14565523 )		2003

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Genes for Pilocytic Astrocytoma of Cerebellum

Genes related to Pilocytic Astrocytoma of Cerebellum (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PNKP	Polynucleotide Kinase 3'-Phosphatase	Protein Coding	16.2	DISEASES inferred ¹⁵
2	KIAA1549	KIAA1549	Protein Coding	15.65	DISEASES inferred ¹⁵
3	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic	Protein Coding	15.65	DISEASES inferred ¹⁵
4	MARK3	Microtubule Affinity Regulating Kinase 3	Protein Coding	15.4	DISEASES inferred ¹⁵
5	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	15.05	DISEASES inferred ¹⁵
6	IDH2	Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial	Protein Coding	14.66	DISEASES inferred ¹⁵
7	GNAS	GNAS Complex Locus	Protein Coding	14.33	DISEASES inferred ¹⁵
8	NF1	Neurofibromin 1	Protein Coding	13.6	DISEASES inferred ¹⁵
9	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	13.31	DISEASES inferred ¹⁵
10	MEG8	Maternally Expressed 8, Small Nucleolar RNA Host Gene	RNA Gene	5.1	DISEASES inferred ¹⁵

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Variations for Pilocytic Astrocytoma of Cerebellum

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Expression for Pilocytic Astrocytoma of Cerebellum

Search GEO for disease gene expression data for Pilocytic Astrocytoma of Cerebellum.

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Pathways for Pilocytic Astrocytoma of Cerebellum

Pathways related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	HIV Life Cycle ⁶⁶ Show member pathways 2-LTR circle formation ⁶⁶ APOBEC3G mediated resistance to HIV-1 infection ⁶⁶ Assembly Of The HIV Virion ⁶⁶ Binding and entry of HIV virion ⁶⁶ Disease ⁶⁶ Diseases of signal transduction ⁶⁶ Early Phase of HIV Life Cycle ⁶⁶ HIV Infection ⁶⁶ Host Interactions of HIV factors ⁶⁶ Infectious disease ⁶⁶ Integration of provirus ⁶⁶ Late Phase of HIV Life Cycle ⁶⁶	13.46	BRAF IDH1 KIAA1549 MAPK3 MARK3 NF1
2	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.54	BRAF GNAS MAPK3 NF1
3	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.5	BRAF GNAS MAPK3 NF1
4	Cushing syndrome ³⁷ Show member pathways Melanogenesis ³⁷	12.22	BRAF GNAS MAPK3
5	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.19	BRAF MAPK3 NF1
6	G-protein signaling G-Protein alpha-i signaling cascades ²² Show member pathways Development Beta-adrenergic receptors regulation of ERK ²² G-protein signaling G-Protein alpha-s signaling cascades ²² G-protein signaling G-Protein beta/gamma signaling cascades ²²	12.17	BRAF GNAS MAPK3
7	cAMP signaling pathway ³⁷ Show member pathways Hydroxycarboxylic acid-binding receptors ⁶⁶	12.08	BRAF GNAS MAPK3
8	Long-term potentiation ³⁷ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁵	11.98	BRAF GNAS MAPK3
9	Colorectal Cancer Metastasis ⁶⁴	11.97	BRAF GNAS MAPK3
10	Development A2A receptor signaling ²² Show member pathways Development A2B receptor- action via G-protein alpha s ²²	11.82	BRAF GNAS MAPK3
11	Serotonergic synapse ³⁷	11.76	BRAF GNAS MAPK3
12	Paradoxical activation of RAF signaling by kinase inactive BRAF ⁶⁶ Show member pathways MAP2K and MAPK activation ⁶⁶ Signaling by high-kinase activity BRAF mutants ⁶⁶ Signaling by moderate kinase activity BRAF mutants ⁶⁶ Signaling by RAS mutants ⁶⁶	11.76	BRAF MAPK3 MARK3 NF1
13	MAP Kinase Signaling ⁴	11.74	BRAF MAPK3 NF1
14	Glioblastoma Multiforme ⁶⁴	11.72	BRAF MAPK3 NF1
15	Parathyroid hormone synthesis, secretion and action ³⁷	11.68	BRAF GNAS MAPK3
16	Corticotropin-releasing hormone signaling pathway ¹	11.58	BRAF GNAS MAPK3
17	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.41	BRAF GNAS MAPK3
18	G-protein signaling TC21 regulation pathway ²² Show member pathways G-protein signaling M-RAS regulation pathway ²² Negative feedback regulation of MAPK pathway ⁶⁶	11.37	BRAF MAPK3 NF1
19	Negative regulation of MAPK pathway ⁶⁶ Show member pathways RAF activation ⁶⁶	11.31	BRAF MAPK3 MARK3
20	Vemurafenib Pathway, Pharmacodynamics ⁶¹	11.27	BRAF MAPK3
21	Long-term depression ³⁷	11.21	BRAF GNAS MAPK3
22	Semaphorin Signaling ⁶⁴	11.2	BRAF MAPK3 NF1
23	G-protein signaling_Cross-talk between Ras-family GTPases ²²	11.19	BRAF GNAS MAPK3
24	Oncogenic MAPK signaling ⁶⁶ Show member pathways Signaling by BRAF and RAF fusions ⁶⁶	11.15	BRAF KIAA1549 MAPK3 MARK3 NF1
25	Syndecan-2-mediated signaling events ¹	11.13	MAPK3 NF1
26	Trk receptor signaling mediated by the MAPK pathway ¹ Show member pathways Signalling to ERK5 ⁶⁶	11.1	BRAF MAPK3
27	Estrogen signaling pathway ¹	10.95	BRAF GNAS
28	Cytosine methylation ¹ Show member pathways TET1,2,3 and TDG demethylate DNA ⁶⁶	10.65	IDH1 IDH2
29	Serotonin Receptor 4/6/7 and NR3C Signaling ¹	10.41	BRAF GNAS MAPK3

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GO Terms for Pilocytic Astrocytoma of Cerebellum

Cellular components related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrion	GO:0005739	9.02	BRAF IDH1 IDH2 MAPK3 PNKP

Biological processes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.81	BRAF MAPK3 MARK3 PNKP
2	cognition	GO:0050890	9.54	GNAS NF1
3	thymus development	GO:0048538	9.52	BRAF MAPK3
4	positive regulation of telomerase activity	GO:0051973	9.49	MAPK3 PNKP
5	positive regulation of telomere maintenance via telomerase	GO:0032212	9.48	MAPK3 PNKP
6	tricarboxylic acid cycle	GO:0006099	9.46	IDH1 IDH2
7	thyroid gland development	GO:0030878	9.43	BRAF MAPK3
8	2-oxoglutarate metabolic process	GO:0006103	9.4	IDH1 IDH2
9	face development	GO:0060324	9.37	BRAF MAPK3
10	positive regulation of telomere capping	GO:1904355	9.32	MAPK3 PNKP
11	NADP metabolic process	GO:0006739	9.26	IDH1 IDH2
12	MAPK cascade	GO:0000165	9.26	BRAF MAPK3 MARK3 NF1
13	isocitrate metabolic process	GO:0006102	9.16	IDH1 IDH2
14	glyoxylate cycle	GO:0006097	8.62	IDH1 IDH2

Molecular functions related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.56	BRAF MAPK3 MARK3 PNKP
2	NAD binding	GO:0051287	9.32	IDH1 IDH2
3	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0016616	9.16	IDH1 IDH2
4	isocitrate dehydrogenase (NADP+) activity	GO:0004450	8.96	IDH1 IDH2
5	isocitrate dehydrogenase activity	GO:0004448	8.62	IDH1 IDH2

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Sources for Pilocytic Astrocytoma of Cerebellum

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

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⁷⁶ Wikipedia