MCID: PLC004
MIFTS: 38

Pilocytic Astrocytoma of Cerebellum

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Pilocytic Astrocytoma of Cerebellum

MalaCards integrated aliases for Pilocytic Astrocytoma of Cerebellum:

Name: Pilocytic Astrocytoma of Cerebellum 12 15 74
Cerebellar Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4853
NCIt 51 C6809
UMLS 74 C0349620

Summaries for Pilocytic Astrocytoma of Cerebellum

MalaCards based summary : Pilocytic Astrocytoma of Cerebellum, also known as cerebellar pilocytic astrocytoma, is related to pleomorphic xanthoastrocytoma and pilocytic astrocytoma, and has symptoms including nausea and vomiting and headache. An important gene associated with Pilocytic Astrocytoma of Cerebellum is PNKP (Polynucleotide Kinase 3'-Phosphatase), and among its related pathways/superpathways are HIV Life Cycle and Pathways in cancer. Affiliated tissues include cerebellum, brain and tongue, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pilocytic Astrocytoma of Cerebellum

Diseases related to Pilocytic Astrocytoma of Cerebellum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 pleomorphic xanthoastrocytoma 30.5 BRAF IDH1
2 pilocytic astrocytoma 30.1 BRAF IDH1 KIAA1549 NF1
3 glioblastoma 29.0 BRAF IDH1 IDH2 MAPK3 NF1
4 astrocytoma 10.3
5 childhood oligodendroglioma 10.3 IDH1 KIAA1549
6 enchondroma 10.3 IDH1 IDH2
7 ganglioglioma 10.3
8 interval angle-closure glaucoma 10.3 IDH1 IDH2
9 intracranial chondrosarcoma 10.3 IDH1 IDH2
10 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
11 chondroblastic osteosarcoma 10.2 IDH1 IDH2
12 intraductal papilloma 10.2 IDH1 IDH2
13 spindle cell hemangioma 10.2 IDH1 IDH2
14 periosteal chondrosarcoma 10.2 IDH1 IDH2
15 glioma susceptibility 1 10.2 IDH1 IDH2
16 adult astrocytic tumour 10.2 IDH1 IDH2
17 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
18 cerebellum cancer 10.2 PNKP SHH
19 drug-induced mental disorder 10.2 IDH1 IDH2
20 drug psychosis 10.2 IDH1 IDH2
21 undifferentiated pleomorphic sarcoma 10.2 IDH1 IDH2
22 villous adenoma 10.1 BRAF GNAS
23 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
24 neurofibromatosis, type i 10.1
25 neurofibromatosis, type iv, of riccardi 10.1
26 autism 10.1
27 thrombocytopenia 10.1
28 autism spectrum disorder 10.1
29 albright's hereditary osteodystrophy 10.1
30 meningitis 10.1
31 tremor 10.1
32 d-2-hydroxyglutaric aciduria 1 10.1 IDH1 IDH2
33 fibrillary astrocytoma 10.1 IDH1 IDH2 KIAA1549
34 peripheral osteosarcoma 10.1 GNAS IDH1
35 brain stem glioma 10.0 BRAF IDH1 IDH2
36 mucosal melanoma 10.0 BRAF NF1
37 multiple enchondromatosis, maffucci type 10.0 GNAS IDH1 IDH2
38 leopard syndrome 10.0 BRAF NF1
39 cerebellar astrocytoma 10.0 IDH1 KIAA1549 MARK3 PNKP
40 adult medulloblastoma 10.0 IDH1 SHH
41 myeloma, multiple 10.0 BRAF IDH1 IDH2
42 pineal parenchymal tumor of intermediate differentiation 9.9 IDH1 NF1
43 pilomyxoid astrocytoma 9.9 BRAF KIAA1549 NF1
44 cholangiocarcinoma 9.9 BRAF IDH1 IDH2
45 adult oligodendroglioma 9.9 IDH1 IDH2 NF1
46 urachal adenocarcinoma 9.9 BRAF GNAS NF1
47 bile duct adenocarcinoma 9.9 IDH1 IDH2
48 osteofibrous dysplasia 9.8 GNAS NF1
49 supratentorial cancer 9.7 IDH1 IDH2 KIAA1549 NF1
50 cerebrum cancer 9.7 IDH1 IDH2 KIAA1549 NF1

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma of Cerebellum:



Diseases related to Pilocytic Astrocytoma of Cerebellum

Symptoms & Phenotypes for Pilocytic Astrocytoma of Cerebellum

UMLS symptoms related to Pilocytic Astrocytoma of Cerebellum:


nausea and vomiting, headache

GenomeRNAi Phenotypes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.86 BRAF MARK3
2 Decreased viability GR00221-A-1 9.86 MARK3 NF1
3 Decreased viability GR00221-A-2 9.86 MARK3 NF1
4 Decreased viability GR00221-A-4 9.86 BRAF MAPK3 MARK3 NF1
5 Decreased viability GR00301-A 9.86 BRAF
6 Decreased viability GR00381-A-1 9.86 BRAF
7 Decreased viability GR00402-S-2 9.86 BRAF MAPK3 MARK3 NF1
8 Decreased cell migration GR00055-A-1 9.46 BRAF MAPK3 MARK3 NF1
9 Increased cell migration GR00055-A-3 8.92 BRAF MAPK3 MARK3 NF1

MGI Mouse Phenotypes related to Pilocytic Astrocytoma of Cerebellum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.01 BRAF GNAS IDH1 MAPK3 MARK3 NF1
2 cardiovascular system MP:0005385 10 BRAF GNAS IDH2 MAPK3 NF1 PNKP
3 homeostasis/metabolism MP:0005376 9.97 BRAF GNAS IDH1 KIAA1549 MAPK3 MARK3
4 craniofacial MP:0005382 9.83 BRAF GNAS MAPK3 NF1 SHH
5 hearing/vestibular/ear MP:0005377 9.77 BRAF GNAS MAPK3 NF1 SHH
6 integument MP:0010771 9.73 BRAF GNAS KRT75 MAPK3 NF1 SHH
7 liver/biliary system MP:0005370 9.63 BRAF GNAS MAPK3 MARK3 NF1 SHH
8 neoplasm MP:0002006 9.43 BRAF GNAS IDH2 MAPK3 NF1 SHH
9 respiratory system MP:0005388 9.1 BRAF GNAS IDH1 MAPK3 NF1 SHH

Drugs & Therapeutics for Pilocytic Astrocytoma of Cerebellum

Search Clinical Trials , NIH Clinical Center for Pilocytic Astrocytoma of Cerebellum

Genetic Tests for Pilocytic Astrocytoma of Cerebellum

Anatomical Context for Pilocytic Astrocytoma of Cerebellum

MalaCards organs/tissues related to Pilocytic Astrocytoma of Cerebellum:

42
Cerebellum, Brain, Tongue, Pancreas, Myeloid, Pineal

Publications for Pilocytic Astrocytoma of Cerebellum

Articles related to Pilocytic Astrocytoma of Cerebellum:

(show all 35)
# Title Authors Year
1
Solid non-enhancing cerebellar pilocytic astrocytoma case report. ( 30366781 )
2019
2
The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma. ( 30770993 )
2019
3
Cerebellar pilocytic astrocytoma in childhood: Investigating the long-term impact of surgery on cognitive performance and functional outcome. ( 28968151 )
2018
4
Supratentorial extension of large cerebellar pilocytic astrocytoma in adult. ( 29446978 )
2018
5
Pediatric cerebellar pilocytic astrocytoma presenting with spontaneous intratumoral hemorrhage. ( 29569086 )
2018
6
Longitudinal mutational analysis of a cerebellar pilocytic astrocytoma recurring as a ganglioglioma. ( 27718322 )
2017
7
A rare case of infantile cerebellar pilocytic astrocytoma and thrombocytopenia presenting with intratumoral hemorrhage. ( 27857799 )
2016
8
Postoperative surveillance of pediatric cerebellar pilocytic astrocytoma. ( 27502785 )
2016
9
Massive Calcified Cerebellar Pilocytic Astrocytoma with Rapid Recurrence : A Rare Case. ( 27651876 )
2016
10
Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma. ( 26181420 )
2015
11
Clinical evidence of the role of the cerebellum in the suppression of overt articulatory movements during reading. A study of reading in children and adolescents treated for cerebellar pilocytic astrocytoma. ( 25326652 )
2015
12
Long-term functional outcome of patients with cerebellar pilocytic astrocytoma surgically treated in childhood. ( 25383654 )
2015
13
Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. ( 28503586 )
2015
14
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. ( 23884731 )
2014
15
Cerebellar pilocytic astrocytoma in adults: a management paradigm for a rare tumour. ( 23793962 )
2013
16
Hemorrhagic onset of cerebellar pilocytic astrocytoma in an adult: a case report and review of the literature implying a possible relation of degenerative vascular changes to the massive intratumoral hemorrhage. ( 22009025 )
2012
17
Infantile cerebellar pilocytic astrocytoma with autism spectrum disorder. ( 22791126 )
2012
18
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. ( 21274720 )
2011
19
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . ( 21515958 )
2011
20
Multicompartmental cerebrospinal fluid dissemination of cerebellar pilocytic astrocytoma at presentation. ( 21764319 )
2011
21
Pediatric cerebellar pilocytic astrocytoma presenting with hemorrhage. ( 21150081 )
2010
22
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. ( 18629510 )
2009
23
Isolated tongue tremor after removal of cerebellar pilocytic astrocytoma: Functional analysis with SPECT study. ( 17657811 )
2007
24
Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults. ( 16245213 )
2005
25
Cerebellar pilocytic astrocytoma with auditory presentation: case study. ( 16417863 )
2005
26
Spontaneous anaplasia in pilocytic astrocytoma of cerebellum. ( 14565523 )
2003
27
Quality-of-life assessment in patients who had been surgically treated for cerebellar pilocytic astrocytoma in childhood. ( 11838795 )
2002
28
Albright's hereditary osteodystrophy associated with cerebellar pilocytic astrocytoma: coincidence or genetic relationship? ( 11598374 )
2001
29
Benign recurrence of a cerebellar pilocytic astrocytoma 45 years after gross total resection. ( 10819266 )
2000
30
Transient peduncular hallucinations secondary to brain stem compression by a cerebellar pilocytic astrocytoma. ( 10070472 )
1998
31
The use of early postoperative MR in detecting residual juvenile cerebellar pilocytic astrocytoma. ( 9432173 )
1998
32
Cerebellar pilocytic astrocytoma: a treatment protocol based upon analysis of 73 cases and a review of the literature. ( 9083697 )
1997
33
Cerebellar pilocytic astrocytoma with leptomeningeal dissemination: case report. ( 9199684 )
1997
34
Unusual early recurrence of a cerebellar pilocytic astrocytoma following complete surgical resection. Case report and review of the literature. ( 8865002 )
1996
35
Leptomeningeal dissemination of cerebellar pilocytic astrocytoma. Case report. ( 1403124 )
1992

Variations for Pilocytic Astrocytoma of Cerebellum

Expression for Pilocytic Astrocytoma of Cerebellum

Search GEO for disease gene expression data for Pilocytic Astrocytoma of Cerebellum.

Pathways for Pilocytic Astrocytoma of Cerebellum

Pathways related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 BRAF IDH1 KIAA1549 MAPK3 MARK3 NF1
2 12.63 BRAF GNAS MAPK3 SHH
3
Show member pathways
12.51 BRAF GNAS MAPK3 NF1
4
Show member pathways
12.47 BRAF GNAS MAPK3 NF1
5 12.13 BRAF GNAS MAPK3
6 12.1 BRAF MAPK3 SHH
7
Show member pathways
11.99 BRAF GNAS MAPK3
8 11.98 BRAF GNAS MAPK3
9
Show member pathways
11.82 BRAF GNAS MAPK3
10 11.77 BRAF GNAS MAPK3
11
Show member pathways
11.76 BRAF MAPK3 MARK3 NF1
12 11.75 BRAF MAPK3 NF1
13 11.73 BRAF MAPK3 NF1
14 11.68 BRAF GNAS MAPK3
15 11.58 BRAF GNAS MAPK3
16 11.41 BRAF GNAS MAPK3
17
Show member pathways
11.37 BRAF MAPK3 NF1
18
Show member pathways
11.31 BRAF MAPK3 MARK3
19 11.21 BRAF GNAS MAPK3
20 11.2 BRAF MAPK3 NF1
21 11.15 MAPK3 NF1
22
Show member pathways
11.15 BRAF KIAA1549 MAPK3 MARK3 NF1
23
Show member pathways
11.1 BRAF MAPK3
24 10.95 BRAF GNAS
25
Show member pathways
10.61 IDH1 IDH2
26 10.41 BRAF GNAS MAPK3

GO Terms for Pilocytic Astrocytoma of Cerebellum

Cellular components related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.28 BRAF GNAS IDH1 IDH2 KRT75 MAPK3

Biological processes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.77 MAPK3 NF1 SHH
2 regulation of cell proliferation GO:0042127 9.7 BRAF NF1 SHH
3 MAPK cascade GO:0000165 9.67 BRAF MAPK3 MARK3 NF1
4 establishment of cell polarity GO:0030010 9.59 MARK3 SHH
5 metanephros development GO:0001656 9.58 NF1 SHH
6 positive regulation of telomerase activity GO:0051973 9.58 MAPK3 PNKP
7 positive regulation of telomere maintenance via telomerase GO:0032212 9.57 MAPK3 PNKP
8 tricarboxylic acid cycle GO:0006099 9.56 IDH1 IDH2
9 developmental growth GO:0048589 9.55 GNAS SHH
10 embryonic hindlimb morphogenesis GO:0035116 9.54 GNAS SHH
11 lung morphogenesis GO:0060425 9.51 MAPK3 SHH
12 2-oxoglutarate metabolic process GO:0006103 9.49 IDH1 IDH2
13 face development GO:0060324 9.48 BRAF MAPK3
14 positive regulation of telomere capping GO:1904355 9.46 MAPK3 PNKP
15 NADP metabolic process GO:0006739 9.43 IDH1 IDH2
16 thymus development GO:0048538 9.43 BRAF MAPK3 SHH
17 Bergmann glial cell differentiation GO:0060020 9.4 MAPK3 SHH
18 isocitrate metabolic process GO:0006102 9.32 IDH1 IDH2
19 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0043369 9.16 BRAF SHH
20 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2
21 thyroid gland development GO:0030878 8.8 BRAF MAPK3 SHH

Molecular functions related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
2 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
3 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Pilocytic Astrocytoma of Cerebellum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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