MCID: PLC004
MIFTS: 29

Pilocytic Astrocytoma of Cerebellum

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Pilocytic Astrocytoma of Cerebellum

MalaCards integrated aliases for Pilocytic Astrocytoma of Cerebellum:

Name: Pilocytic Astrocytoma of Cerebellum 12 15 71
Cerebellar Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4853
NCIt 49 C6809
UMLS 71 C0349620

Summaries for Pilocytic Astrocytoma of Cerebellum

MalaCards based summary : Pilocytic Astrocytoma of Cerebellum, also known as cerebellar pilocytic astrocytoma, is related to ganglioglioma and juvenile pilocytic astrocytoma, and has symptoms including nausea and vomiting and headache. An important gene associated with Pilocytic Astrocytoma of Cerebellum is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Long-term potentiation and Oncogenic MAPK signaling. Affiliated tissues include cerebellum, brain and bone.

Related Diseases for Pilocytic Astrocytoma of Cerebellum

Diseases related to Pilocytic Astrocytoma of Cerebellum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 ganglioglioma 30.2 KIAA1549 H3-3A BRAF
2 juvenile pilocytic astrocytoma 29.4 KIAA1549 IDH1 H3-3B H3-3A
3 glioblastoma multiforme 28.5 IDH1 H3-3B H3-3A BRAF
4 pleomorphic xanthoastrocytoma 28.4 KIAA1549 IDH1 H3-3B H3-3A FAM131B BRAF
5 cerebellar astrocytoma 26.6 RNF130 PASD1 MKRN1 KIAA1549 IDH1 H3-3B
6 neurofibromatosis, type iv, of riccardi 10.4
7 cerebellar liponeurocytoma 10.3 KIAA1549 FAM131B
8 astrocytoma 10.3
9 optic nerve neoplasm 10.3 KIAA1549 FAM131B
10 hydrocephalus 10.3
11 intracranial hypertension 10.3
12 head injury 10.3
13 low-grade astrocytoma 10.3
14 clear cell ependymoma 10.2 KIAA1549 IDH1
15 mixed glioma 10.2 KIAA1549 IDH1
16 spinal cancer 10.2 KIAA1549 IDH1
17 subependymal glioma 10.2 KIAA1549 FAM131B
18 48,xyyy 10.1
19 cerebral ventricle cancer 10.1 KIAA1549 IDH1
20 pseudohypoparathyroidism, type ia 10.1
21 neurofibromatosis, type i 10.1
22 thyroid cancer, nonmedullary, 1 10.1
23 autism 10.1
24 ataxia and polyneuropathy, adult-onset 10.1
25 autism spectrum disorder 10.1
26 retinal microaneurysm 10.1
27 hemosiderosis 10.1
28 thrombocytopenia 10.1
29 thyroid gland papillary carcinoma 10.1
30 pseudohypoparathyroidism 10.1
31 mutism 10.1
32 meningitis 10.1
33 pituitary tumors 10.1
34 tremor 10.1
35 glial tumor 10.1
36 rare tumor 10.1
37 thyroid carcinoma 10.1
38 cerebrum cancer 10.1 KIAA1549 IDH1
39 astroblastoma 10.1 IDH1 BRAF
40 dysembryoplastic neuroepithelial tumor 10.1 KIAA1549 IDH1 FAM131B
41 papillary craniopharyngioma 10.0 KIAA1549 FAM131B BRAF
42 gliomatosis cerebri 9.9 IDH1 BRAF
43 glioma 9.9 IDH1 H3-3A BRAF
44 juvenile astrocytoma 9.8 KIAA1549 IDH1 FAM131B BRAF
45 diffuse intrinsic pontine glioma 9.7 H3-3B H3-3A
46 bone giant cell sarcoma 9.7 H3-3B H3-3A
47 malignant giant cell tumor 9.7 H3-3B H3-3A
48 telangiectatic osteogenic sarcoma 9.7 H3-3B H3-3A
49 glioma susceptibility 1 9.7 IDH1 H3-3A BRAF
50 supratentorial cancer 9.7 KIAA1549 IDH1 H3-3B

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma of Cerebellum:



Diseases related to Pilocytic Astrocytoma of Cerebellum

Symptoms & Phenotypes for Pilocytic Astrocytoma of Cerebellum

UMLS symptoms related to Pilocytic Astrocytoma of Cerebellum:


nausea and vomiting, headache

Drugs & Therapeutics for Pilocytic Astrocytoma of Cerebellum

Search Clinical Trials , NIH Clinical Center for Pilocytic Astrocytoma of Cerebellum

Genetic Tests for Pilocytic Astrocytoma of Cerebellum

Anatomical Context for Pilocytic Astrocytoma of Cerebellum

MalaCards organs/tissues related to Pilocytic Astrocytoma of Cerebellum:

40
Cerebellum, Brain, Bone, Thyroid, Spinal Cord, B Cells, Tongue

Publications for Pilocytic Astrocytoma of Cerebellum

Articles related to Pilocytic Astrocytoma of Cerebellum:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Deadly Proliferation and Transformation of Pilocytic Astrocytoma in Pregnancy. 61
31574330 2020
2
Functional herniated choroid plexus in brain parenchyma following VP shunt removal. 61
31913712 2020
3
Co-existent pilocytic astrocytoma with acute B-cell leukemia within the cerebellum. 61
31408921 2019
4
Childhood cerebellar tumours mirror conserved fetal transcriptional programs. 61
31043743 2019
5
The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma. 61
30770993 2019
6
Molecular genetics and therapeutic targets of pediatric low-grade gliomas. 61
30929113 2019
7
Prone versus sitting position in pediatric low-grade posterior fossa tumors. 61
30610475 2019
8
Solid non-enhancing cerebellar pilocytic astrocytoma case report. 61
30366781 2019
9
Mathematical skills in children with pilocytic astrocytoma. 61
30523458 2019
10
An elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component in the cerebellar hemisphere. 61
29851180 2018
11
Cerebellar pilocytic astrocytoma in childhood: Investigating the long-term impact of surgery on cognitive performance and functional outcome. 61
28968151 2018
12
Rare compound heterozygous variants in PNKP identified by whole exome sequencing in a German patient with ataxia-oculomotor apraxia 4 and pilocytic astrocytoma. 61
29498415 2018
13
Pediatric cerebellar pilocytic astrocytoma presenting with spontaneous intratumoral hemorrhage. 61
29569086 2018
14
Supratentorial extension of large cerebellar pilocytic astrocytoma in adult. 61
29446978 2018
15
Posterior Fossa Tumors. 61
27889018 2017
16
Longitudinal mutational analysis of a cerebellar pilocytic astrocytoma recurring as a ganglioglioma. 61
27718322 2017
17
Postoperative surveillance of pediatric cerebellar pilocytic astrocytoma. 61
27502785 2016
18
Massive Calcified Cerebellar Pilocytic Astrocytoma with Rapid Recurrence : A Rare Case. 61
27651876 2016
19
A rare case of infantile cerebellar pilocytic astrocytoma and thrombocytopenia presenting with intratumoral hemorrhage. 61
27857799 2016
20
BRAF V600E-mutated diffuse glioma in an adult patient: a case report and review. 61
26445861 2016
21
Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma. 61
26181420 2015
22
Clinical evidence of the role of the cerebellum in the suppression of overt articulatory movements during reading. A study of reading in children and adolescents treated for cerebellar pilocytic astrocytoma. 61
25326652 2015
23
Morphological brain lesions of pediatric cerebellar tumor survivors correlate with inferior neurocognitive function but do not affect health-related quality of life. 61
25686892 2015
24
IDH1 R132H mutation in a pilocytic astrocytoma: a case report. 61
26617931 2015
25
Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. 61
28503586 2015
26
Long-term functional outcome of patients with cerebellar pilocytic astrocytoma surgically treated in childhood. 61
25383654 2015
27
Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma. 61
25883769 2015
28
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. 61
23884731 2014
29
Long-term quality of life in children treated for posterior fossa brain tumors. 61
23829377 2013
30
Cerebellar pilocytic astrocytoma in adults: a management paradigm for a rare tumour. 61
23793962 2013
31
Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations. 61
23082883 2013
32
Short lasting activity-related headaches with sudden onset in children: a case-based reasoning on classification and diagnosis. 61
23565626 2013
33
Hemorrhagic onset of cerebellar pilocytic astrocytoma in an adult: a case report and review of the literature implying a possible relation of degenerative vascular changes to the massive intratumoral hemorrhage. 61
22009025 2012
34
Infantile cerebellar pilocytic astrocytoma with autism spectrum disorder. 61
22791126 2012
35
Multicompartmental cerebrospinal fluid dissemination of cerebellar pilocytic astrocytoma at presentation. 61
21764319 2011
36
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. 61
21274720 2011
37
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . 61
21515958 2011
38
Pediatric cerebellar pilocytic astrocytoma presenting with hemorrhage. 61
21150081 2010
39
Chronic uncal herniation secondary to posterior fossa shunting: case report and literature review. 61
19915852 2010
40
Loss of fine motor function correlates with ataxia and decline of cognition in cerebellar tumor survivors. 61
19484752 2009
41
Posterior fossa neoplasm and PHACES syndrome: a case report. 61
19262249 2009
42
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. 61
18629510 2009
43
Combining anatomic and molecularly targeted imaging in the diagnosis and surveillance of embryonal tumors of the nervous and endocrine systems in children. 61
18581060 2008
44
Isolated tongue tremor after removal of cerebellar pilocytic astrocytoma: Functional analysis with SPECT study. 61
17657811 2007
45
Epilepsy and neuropsychologic deficit in a child with cerebellar astrocytoma. 61
16970895 2006
46
MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images: is it useful for differentiation from medulloblastoma? 61
16550430 2006
47
Cerebellar pilocytic astrocytoma with auditory presentation: case study. 61
16417863 2005
48
[Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors]. 61
15981157 2005
49
Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults. 61
16245213 2005
50
Long-term sequelae in children after cerebellar astrocytoma surgery. 61
15111667 2004

Variations for Pilocytic Astrocytoma of Cerebellum

Expression for Pilocytic Astrocytoma of Cerebellum

Search GEO for disease gene expression data for Pilocytic Astrocytoma of Cerebellum.

Pathways for Pilocytic Astrocytoma of Cerebellum

Pathways related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 H3-3A GNAI1 BRAF
2
Show member pathways
11.06 KIAA1549 FAM131B CLCN6 BRAF
3 10.96 GNAI1 BRAF
4 10.67 H3-3B H3-3A

GO Terms for Pilocytic Astrocytoma of Cerebellum

Cellular components related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear nucleosome GO:0000788 8.96 H3-3B H3-3A
2 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 embryo implantation GO:0007566 9.49 H3-3B H3-3A
2 chromatin silencing at rDNA GO:0000183 9.48 H3-3B H3-3A
3 oogenesis GO:0048477 9.46 H3-3B H3-3A
4 nucleus organization GO:0006997 9.43 H3-3B H3-3A
5 telomere organization GO:0032200 9.4 H3-3B H3-3A
6 DNA replication-independent nucleosome assembly GO:0006336 9.37 H3-3B H3-3A
7 muscle cell differentiation GO:0042692 9.32 H3-3B H3-3A
8 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
9 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
10 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
11 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.96 H3-3B H3-3A
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Pilocytic Astrocytoma of Cerebellum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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