Pilocytic Astrocytoma of Cerebellum disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pilocytic Astrocytoma of Cerebellum

MalaCards integrated aliases for Pilocytic Astrocytoma of Cerebellum:

Name: Pilocytic Astrocytoma of Cerebellum ¹¹ ¹⁴ ⁷¹

Cerebellar Pilocytic Astrocytoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4853

NCIt ⁴⁹ C6809

SNOMED-CT ⁶⁸ 277507004

UMLS ⁷¹ C0349620

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Summaries for Pilocytic Astrocytoma of Cerebellum

MalaCards based summary: Pilocytic Astrocytoma of Cerebellum, also known as cerebellar pilocytic astrocytoma, is related to neurofibromatosis, type i and ganglioglioma, and has symptoms including nausea and vomiting and headache. An important gene associated with Pilocytic Astrocytoma of Cerebellum is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Disease and RAF/MAP kinase cascade. Affiliated tissues include cerebellum, brain and tongue.

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Related Diseases for Pilocytic Astrocytoma of Cerebellum

Diseases related to Pilocytic Astrocytoma of Cerebellum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)

#	Related Disease	Score	Top Affiliating Genes
1	neurofibromatosis, type i	30.4	NF1 KIAA1549 IDH1
2	ganglioglioma	30.1	NF1 H3-3A BRAF
3	obstructive hydrocephalus	30.0	NF1 KIAA1549 H3-3A
4	juvenile pilocytic astrocytoma	29.8	NF1 KIAA1549 IDH1 H3-3A
5	pleomorphic xanthoastrocytoma	29.3	NF1 KIAA1549 IDH1 H3-3A FAM131B BRAF
6	pilocytic astrocytoma	29.1	TACC1 RNF130 NF1 KIAA1549 IDH1 H3-3A
7	cerebellar astrocytoma	28.1	TACC1 RNF130 PNKP NF1 KIAA1549 IDH1
8	glioma susceptibility 1	10.3
9	simple partial epilepsy	10.2	KIAA1549 IDH1
10	hydrocephalus	10.2
11	mutism	10.2
12	neurofibromatosis	10.2
13	low-grade astrocytoma	10.2
14	chordoid glioma	10.2	KIAA1549 IDH1
15	gangliocytoma	10.2	KIAA1549 IDH1
16	chondroma	10.2	NF1 IDH1
17	epidural spinal canal neoplasm	10.2	NF1 KIAA1549
18	astroblastoma	10.2	KIAA1549 IDH1
19	optic nerve astrocytoma	10.2	NF1 IDH1
20	rela fusion-positive ependymoma	10.2	KIAA1549 IDH1
21	spinal cord oligodendroglioma	10.2	NF1 IDH1
22	glioblastoma	10.2
23	acral lentiginous melanoma	10.1	NF1 BRAF
24	mixed glioma	10.1	NF1 IDH1
25	central neurocytoma	10.1	KIAA1549 IDH1
26	non-langerhans-cell histiocytosis	10.1	NF1 BRAF
27	optic nerve neoplasm	10.1	NF1 KIAA1549 FAM131B
28	pulmonic stenosis	10.1	NF1 BRAF
29	subependymal glioma	10.1	NF1 KIAA1549 IDH1
30	pseudohypoparathyroidism, type ia	10.1
31	thyroid cancer, nonmedullary, 1	10.1
32	autism	10.1
33	neurofibromatosis-noonan syndrome	10.1
34	meningioma, familial	10.1
35	iron overload	10.1
36	autism spectrum disorder	10.1
37	central diabetes insipidus	10.1
38	hemosiderosis	10.1
39	quadriplegia	10.1
40	reading disorder	10.1
41	thrombocytopenia	10.1
42	malignant astrocytoma	10.1
43	turner syndrome	10.1
44	central nervous system cancer	10.1
45	pituitary adenoma	10.1
46	pseudohypoparathyroidism	10.1
47	adenoma	10.1
48	diabetes insipidus	10.1
49	intracranial hypertension	10.1
50	meningitis	10.1

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma of Cerebellum:

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Symptoms & Phenotypes for Pilocytic Astrocytoma of Cerebellum

UMLS symptoms related to Pilocytic Astrocytoma of Cerebellum:

nausea and vomiting; headache

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Drugs & Therapeutics for Pilocytic Astrocytoma of Cerebellum

Search Clinical Trials, NIH Clinical Center for Pilocytic Astrocytoma of Cerebellum

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Genetic Tests for Pilocytic Astrocytoma of Cerebellum

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Anatomical Context for Pilocytic Astrocytoma of Cerebellum

Organs/tissues related to Pilocytic Astrocytoma of Cerebellum:

MalaCards : Cerebellum, Brain, Tongue

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Publications for Pilocytic Astrocytoma of Cerebellum

Articles related to Pilocytic Astrocytoma of Cerebellum:

(show top 50) (show all 75)

#	Title	Authors	PMID	Year
1	Novel Use of the Aurora Surgiscope System for Minimally Invasive Resection of Intraparenchymal Lesions: A Case Series. ⁶²	Achey RL...Bain M	35972079	2022
2	Infiltration in Pilocytic Astrocytoma: A Diagnostic Pitfall. ⁶²	Alturkustani M	36120224	2022
3	The Utility of Intraoperative Magnetic Resonance Imaging in the Resection of Cerebellar Hemispheric Pilocytic Astrocytomas: A Cohort Study. ⁶²	Hamilton KM...Chern JJ	35147577	2022
4	Outcome of Childhood Cerebellar Pilocytic Astrocytoma: A Series With 20 Years of Follow Up. ⁶²	Elwatidy SM...Elwatidy HS	35350495	2022
5	Corrigendum to: Cerebellar Pilocytic Astrocytoma with a Sacral Drop Metastasis in an Adult. ⁶²		35098311	2022
6	Occipital Intradiploic Pseudomeningocele - A Rare Complication of Pediatric Posterior Cranial Fossa Surgery: Case Report and Review of the Literature. ⁶²	Bonomo G...Carrabba GG	35988537	2022
7	Large Residual Pilocytic Astrocytoma After Failed Ultrasound-Guided Resection: Intraoperative Ultrasound Limitations Require Special Attention. ⁶²	Steno A...Steno J	33819702	2021
8	Rapid Recurrence and Anaplastic Transformation of a Pilocytic Astrocytoma in an Elderly Patient: Case Report and Review of the Literature. ⁶²	Tanaka T...Yokoo H	32634636	2020
9	Supratentorial extension of large cerebellar pilocytic astrocytoma in adult. ⁶²	Singh SK...Agarwal H	29446978	2020
10	Low-Grade Gliomas in Patients with Noonan Syndrome: Case-Based Review of the Literature. ⁶²	Lodi M...Mastronuzzi A	32806529	2020
11	Postoperative Tetraplegia to a Child after Cerebellar Pilocytic Astrocytoma Excision at Prone Position: Case Report and Literature Review. ⁶²	Panagopoulos D...Themistocleous M	32161253	2020
12	Pediatric cerebellar pilocytic astrocytoma presenting with spontaneous intratumoral hemorrhage. ⁶²	Donofrio CA...Mortini P	29569086	2020
13	Deadly Proliferation and Transformation of Pilocytic Astrocytoma in Pregnancy. ⁶²	Schmidt BT...Hanna A	31574330	2020
14	In silico analysis identifies a putative cell-of-origin for BRAF fusion-positive cerebellar pilocytic astrocytoma. ⁶²	Younes ST...Herrington B	33206716	2020
15	Functional herniated choroid plexus in brain parenchyma following VP shunt removal. ⁶²	El Sheikh M...Hossain-Ibrahim K	31913712	2020
16	Co-existent pilocytic astrocytoma with acute B-cell leukemia within the cerebellum. ⁶²	Hickman R...Goldman J	31408921	2019
17	Childhood cerebellar tumours mirror conserved fetal transcriptional programs. ⁶²	Vladoiu MC...Taylor MD	31043743	2019
18	The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma. ⁶²	McAuley E...Pizer B	30770993	2019
19	Molecular genetics and therapeutic targets of pediatric low-grade gliomas. ⁶²	Tateishi K...Yamamoto T	30929113	2019
20	Prone versus sitting position in pediatric low-grade posterior fossa tumors. ⁶²	Baro V...d'Avella D	30610475	2019
21	Solid non-enhancing cerebellar pilocytic astrocytoma case report. ⁶²	Towner JE...Drummond K	30366781	2019
22	Mathematical skills in children with pilocytic astrocytoma. ⁶²	Benavides-Varela S...Semenza C	30523458	2019
23	An elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component in the cerebellar hemisphere. ⁶²	Sangatsuda Y...Iihara K	29851180	2018
24	Cerebellar pilocytic astrocytoma in childhood: Investigating the long-term impact of surgery on cognitive performance and functional outcome. ⁶²	Pletschko T...Leiss U	28968151	2018
25	Rare compound heterozygous variants in PNKP identified by whole exome sequencing in a German patient with ataxia-oculomotor apraxia 4 and pilocytic astrocytoma. ⁶²	Scholz C...Hofmann W	29498415	2018
26	Longitudinal mutational analysis of a cerebellar pilocytic astrocytoma recurring as a ganglioglioma. ⁶²	Fiset PO...Albrecht S	27718322	2017
27	Posterior Fossa Tumors. ⁶²	Brandao LA...Young Poussaint T	27889018	2017
28	Postoperative surveillance of pediatric cerebellar pilocytic astrocytoma. ⁶²	Alford R...Koral K	27502785	2016
29	Massive Calcified Cerebellar Pilocytic Astrocytoma with Rapid Recurrence : A Rare Case. ⁶²	Aydemir F...Tufan K	27651876	2016
30	A rare case of infantile cerebellar pilocytic astrocytoma and thrombocytopenia presenting with intratumoral hemorrhage. ⁶²	Ramdurg SR...Maitra J	27857799	2016
31	BRAF V600E-mutated diffuse glioma in an adult patient: a case report and review. ⁶²	Suzuki Y...Murayama Y	26445861	2016
32	Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma. ⁶²	Davis J...Hummel TR	26181420	2015
33	Clinical evidence of the role of the cerebellum in the suppression of overt articulatory movements during reading. A study of reading in children and adolescents treated for cerebellar pilocytic astrocytoma. ⁶²	Ait Khelifa-Gallois N...Dellatolas G	25326652	2015
34	Morphological brain lesions of pediatric cerebellar tumor survivors correlate with inferior neurocognitive function but do not affect health-related quality of life. ⁶²	Khajuria RK...Driever PH	25686892	2015
35	Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma. ⁶²	Taha H...El-Naggar S	25883769	2015
36	Long-term functional outcome of patients with cerebellar pilocytic astrocytoma surgically treated in childhood. ⁶²	Ait Khelifa-Gallois N...Dellatolas G	25383654	2015
37	Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. ⁶²	Coelho J...Salgado D	28503586	2015
38	IDH1 R132H mutation in a pilocytic astrocytoma: a case report. ⁶²	Behling F...Schittenhelm J	26617931	2015
39	Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. ⁶²	Sasaki T...Tominaga T	23884731	2014
40	Long-term quality of life in children treated for posterior fossa brain tumors. ⁶²	Kulkarni AV...Bouffet E	23829377	2013
41	Cerebellar pilocytic astrocytoma in adults: a management paradigm for a rare tumour. ⁶²	Wade A...Leach P	23793962	2013
42	Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations. ⁶²	Kanoke A...Tominaga T	23082883	2013
43	Short lasting activity-related headaches with sudden onset in children: a case-based reasoning on classification and diagnosis. ⁶²	Toldo I...Battistella PA	23565626	2013
44	Hemorrhagic onset of cerebellar pilocytic astrocytoma in an adult: a case report and review of the literature implying a possible relation of degenerative vascular changes to the massive intratumoral hemorrhage. ⁶²	Shibao S...Yoshida K	22009025	2012
45	Infantile cerebellar pilocytic astrocytoma with autism spectrum disorder. ⁶²	Adachi K...Teramoto A	22791126	2012
46	Multicompartmental cerebrospinal fluid dissemination of cerebellar pilocytic astrocytoma at presentation. ⁶²	Redhu R...Nadkarni TD	21764319	2011
47	Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. ⁶²	Schindler G...von Deimling A	21274720	2011
48	Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . ⁶²	Tsuda K...Matsumura A	21515958	2011
49	Pediatric cerebellar pilocytic astrocytoma presenting with hemorrhage. ⁶²	Kumar A...Mhatre MV	21150081	2010
50	Chronic uncal herniation secondary to posterior fossa shunting: case report and literature review. ⁶²	Udayakumaran S...Constantini S	19915852	2010

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Genes for Pilocytic Astrocytoma of Cerebellum

Genes related to Pilocytic Astrocytoma of Cerebellum (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KIAA1549	KIAA1549	Protein Coding	7.17	DISEASES inferred ¹⁴
2	FAM131B	Family With Sequence Similarity 131 Member B	Protein Coding	5.97	DISEASES inferred ¹⁴
3	RNF130	Ring Finger Protein 130	Protein Coding	5.59	DISEASES inferred ¹⁴
4	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	5.45	DISEASES inferred ¹⁴
5	CNTN3	Contactin 3	Protein Coding	5.3	DISEASES inferred ¹⁴
6	NF1	Neurofibromin 1	Protein Coding	5.27	DISEASES inferred ¹⁴
7	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5.23	DISEASES inferred ¹⁴
8	PNKP	Polynucleotide Kinase 3'-Phosphatase	Protein Coding	5.21	DISEASES inferred ¹⁴
9	TACC1	Transforming Acidic Coiled-Coil Containing Protein 1	Protein Coding	5.04	DISEASES inferred ¹⁴
10	IRX2	Iroquois Homeobox 2	Protein Coding	5.01	DISEASES inferred ¹⁴
11	H3-3A	H3.3 Histone A	Protein Coding	5	DISEASES inferred ¹⁴
12	PASD1	PAS Domain Containing Repressor 1	Protein Coding	4.96	DISEASES inferred ¹⁴
13	CLCN6	Chloride Voltage-Gated Channel 6	Protein Coding	4.92	DISEASES inferred ¹⁴

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Variations for Pilocytic Astrocytoma of Cerebellum

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Expression for Pilocytic Astrocytoma of Cerebellum

Search GEO for disease gene expression data for Pilocytic Astrocytoma of Cerebellum.

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Pathways for Pilocytic Astrocytoma of Cerebellum

Pathways related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	12.93	NF1 KIAA1549 IDH1 H3-3A FAM131B CLCN6
2	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	12.78	NF1 KIAA1549 FAM131B CLCN6 BRAF
3	Oncogenic MAPK signaling ⁶⁶ Show member pathways Signaling by BRAF and RAF1 fusions ⁶⁶	11.2	NF1 KIAA1549 FAM131B CLCN6 BRAF
4	G-protein signaling TC21 regulation pathway ²² Show member pathways G-protein signaling M-RAS regulation pathway ²² Negative feedback regulation of MAPK pathway ⁶⁶ Signaling by MAP2K mutants ⁶⁶	10.92	NF1 BRAF

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GO Terms for Pilocytic Astrocytoma of Cerebellum

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Sources for Pilocytic Astrocytoma of Cerebellum

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

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¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

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²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

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⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PLC004 MIFTS: 25	Pilocytic Astrocytoma of Cerebellum Categories: Cancer diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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