MCID: PLC004
MIFTS: 28

Pilocytic Astrocytoma of Cerebellum

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Pilocytic Astrocytoma of Cerebellum

MalaCards integrated aliases for Pilocytic Astrocytoma of Cerebellum:

Name: Pilocytic Astrocytoma of Cerebellum 12 15 71
Cerebellar Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4853
NCIt 49 C6809
SNOMED-CT 67 277507004
UMLS 71 C0349620

Summaries for Pilocytic Astrocytoma of Cerebellum

MalaCards based summary : Pilocytic Astrocytoma of Cerebellum, also known as cerebellar pilocytic astrocytoma, is related to juvenile pilocytic astrocytoma and ganglioglioma, and has symptoms including nausea and vomiting and headache. An important gene associated with Pilocytic Astrocytoma of Cerebellum is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Oncogenic MAPK signaling and G-protein signaling TC21 regulation pathway. Affiliated tissues include cerebellum, bone and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pilocytic Astrocytoma of Cerebellum

Diseases related to Pilocytic Astrocytoma of Cerebellum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 juvenile pilocytic astrocytoma 30.4 NF1 KIAA1549 IDH1
2 ganglioglioma 30.0 NF1 KIAA1549 IDH1 BRAF
3 pleomorphic xanthoastrocytoma 29.4 NF1 KIAA1549 IDH1 FAM131B BRAF
4 glioblastoma multiforme 28.5 NF1 IDH1 H3C11 H3C10 BRAF
5 cerebellar astrocytoma 25.7 RNF130 PASD1 NF1 MKRN1 KIAA1549 IDH1
6 hydrocephalus 10.4
7 neurofibromatosis 10.4
8 pediatric meningioma 10.3 KIAA1549 FAM131B
9 spinal cord astrocytoma 10.3 KIAA1549 IDH1
10 astrocytoma 10.3
11 adult astrocytic tumour 10.3 KIAA1549 IDH1
12 intracranial hypertension 10.3
13 head injury 10.3
14 low-grade astrocytoma 10.3
15 spinal cord glioma 10.3 KIAA1549 IDH1
16 malignant ependymoma 10.2 KIAA1549 IDH1
17 astroblastoma 10.2 IDH1 BRAF
18 48,xyyy 10.1
19 childhood oligodendroglioma 10.1 KIAA1549 IDH1 FAM131B
20 supratentorial cancer 10.1 KIAA1549 IDH1
21 pseudohypoparathyroidism, type ia 10.1
22 neurofibromatosis, type i 10.1
23 thyroid cancer, nonmedullary, 1 10.1
24 autism 10.1
25 ataxia and polyneuropathy, adult-onset 10.1
26 autism spectrum disorder 10.1
27 retinal microaneurysm 10.1
28 hemosiderosis 10.1
29 quadriplegia 10.1
30 obstructive hydrocephalus 10.1
31 thrombocytopenia 10.1
32 pseudohypoparathyroidism 10.1
33 mutism 10.1
34 diabetes insipidus 10.1
35 meningitis 10.1
36 pituitary tumors 10.1
37 spasticity 10.1
38 tremor 10.1
39 glial tumor 10.1
40 rare tumor 10.1
41 thyroid carcinoma 10.1
42 urachal adenocarcinoma 10.1 NF1 BRAF
43 papillary craniopharyngioma 10.1 KIAA1549 FAM131B BRAF
44 spinal cord oligodendroglioma 10.1 NF1 IDH1
45 mixed glioma 10.1 NF1 IDH1
46 optic nerve glioma 10.1 NF1 KIAA1549
47 gliomatosis cerebri 10.0 IDH1 BRAF
48 subependymal glioma 10.0 NF1 KIAA1549
49 chondroma 10.0 NF1 IDH1
50 adult oligodendroglioma 10.0 PASD1 KIAA1549 IDH1

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma of Cerebellum:



Diseases related to Pilocytic Astrocytoma of Cerebellum

Symptoms & Phenotypes for Pilocytic Astrocytoma of Cerebellum

UMLS symptoms related to Pilocytic Astrocytoma of Cerebellum:


nausea and vomiting, headache

GenomeRNAi Phenotypes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 9.64 BRAF
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.64 H3C11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.64 FAM131B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 9.64 FAM131B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-159 9.64 H3C11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.64 H3C11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 9.64 BRAF
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.64 BRAF
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.64 H3C11
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-194 9.64 BRAF
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.64 BRAF
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 9.64 BRAF
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-32 9.64 BRAF
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.64 H3C11
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-36 9.64 FAM131B
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.64 FAM131B
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.64 H3C11
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 9.64 FAM131B
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.64 BRAF
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-83 9.64 FAM131B
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-97 9.64 NF1

Drugs & Therapeutics for Pilocytic Astrocytoma of Cerebellum

Search Clinical Trials , NIH Clinical Center for Pilocytic Astrocytoma of Cerebellum

Genetic Tests for Pilocytic Astrocytoma of Cerebellum

Anatomical Context for Pilocytic Astrocytoma of Cerebellum

MalaCards organs/tissues related to Pilocytic Astrocytoma of Cerebellum:

40
Cerebellum, Bone, Brain, B Cells, Tongue

Publications for Pilocytic Astrocytoma of Cerebellum

Articles related to Pilocytic Astrocytoma of Cerebellum:

(show top 50) (show all 65)
# Title Authors PMID Year
1
Postoperative Tetraplegia to a Child after Cerebellar Pilocytic Astrocytoma Excision at Prone Position: Case Report and Literature Review. 61
32161253 2020
2
Pediatric cerebellar pilocytic astrocytoma presenting with spontaneous intratumoral hemorrhage. 61
29569086 2020
3
Deadly Proliferation and Transformation of Pilocytic Astrocytoma in Pregnancy. 61
31574330 2020
4
Functional herniated choroid plexus in brain parenchyma following VP shunt removal. 61
31913712 2020
5
Co-existent pilocytic astrocytoma with acute B-cell leukemia within the cerebellum. 61
31408921 2019
6
Childhood cerebellar tumours mirror conserved fetal transcriptional programs. 61
31043743 2019
7
The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma. 61
30770993 2019
8
Molecular genetics and therapeutic targets of pediatric low-grade gliomas. 61
30929113 2019
9
Prone versus sitting position in pediatric low-grade posterior fossa tumors. 61
30610475 2019
10
Solid non-enhancing cerebellar pilocytic astrocytoma case report. 61
30366781 2019
11
Mathematical skills in children with pilocytic astrocytoma. 61
30523458 2019
12
An elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component in the cerebellar hemisphere. 61
29851180 2018
13
Cerebellar pilocytic astrocytoma in childhood: Investigating the long-term impact of surgery on cognitive performance and functional outcome. 61
28968151 2018
14
Rare compound heterozygous variants in PNKP identified by whole exome sequencing in a German patient with ataxia-oculomotor apraxia 4 and pilocytic astrocytoma. 61
29498415 2018
15
Supratentorial extension of large cerebellar pilocytic astrocytoma in adult. 61
29446978 2018
16
Longitudinal mutational analysis of a cerebellar pilocytic astrocytoma recurring as a ganglioglioma. 61
27718322 2017
17
Posterior Fossa Tumors. 61
27889018 2017
18
Postoperative surveillance of pediatric cerebellar pilocytic astrocytoma. 61
27502785 2016
19
Massive Calcified Cerebellar Pilocytic Astrocytoma with Rapid Recurrence : A Rare Case. 61
27651876 2016
20
A rare case of infantile cerebellar pilocytic astrocytoma and thrombocytopenia presenting with intratumoral hemorrhage. 61
27857799 2016
21
BRAF V600E-mutated diffuse glioma in an adult patient: a case report and review. 61
26445861 2016
22
Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma. 61
26181420 2015
23
Clinical evidence of the role of the cerebellum in the suppression of overt articulatory movements during reading. A study of reading in children and adolescents treated for cerebellar pilocytic astrocytoma. 61
25326652 2015
24
Morphological brain lesions of pediatric cerebellar tumor survivors correlate with inferior neurocognitive function but do not affect health-related quality of life. 61
25686892 2015
25
Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. 61
28503586 2015
26
IDH1 R132H mutation in a pilocytic astrocytoma: a case report. 61
26617931 2015
27
Long-term functional outcome of patients with cerebellar pilocytic astrocytoma surgically treated in childhood. 61
25383654 2015
28
Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma. 61
25883769 2015
29
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. 61
23884731 2014
30
Long-term quality of life in children treated for posterior fossa brain tumors. 61
23829377 2013
31
Cerebellar pilocytic astrocytoma in adults: a management paradigm for a rare tumour. 61
23793962 2013
32
Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations. 61
23082883 2013
33
Short lasting activity-related headaches with sudden onset in children: a case-based reasoning on classification and diagnosis. 61
23565626 2013
34
Hemorrhagic onset of cerebellar pilocytic astrocytoma in an adult: a case report and review of the literature implying a possible relation of degenerative vascular changes to the massive intratumoral hemorrhage. 61
22009025 2012
35
Infantile cerebellar pilocytic astrocytoma with autism spectrum disorder. 61
22791126 2012
36
Multicompartmental cerebrospinal fluid dissemination of cerebellar pilocytic astrocytoma at presentation. 61
21764319 2011
37
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. 61
21274720 2011
38
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . 61
21515958 2011
39
Pediatric cerebellar pilocytic astrocytoma presenting with hemorrhage. 61
21150081 2010
40
Chronic uncal herniation secondary to posterior fossa shunting: case report and literature review. 61
19915852 2010
41
Loss of fine motor function correlates with ataxia and decline of cognition in cerebellar tumor survivors. 61
19484752 2009
42
Posterior fossa neoplasm and PHACES syndrome: a case report. 61
19262249 2009
43
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. 61
18629510 2009
44
Combining anatomic and molecularly targeted imaging in the diagnosis and surveillance of embryonal tumors of the nervous and endocrine systems in children. 61
18581060 2008
45
Isolated tongue tremor after removal of cerebellar pilocytic astrocytoma: Functional analysis with SPECT study. 61
17657811 2007
46
Epilepsy and neuropsychologic deficit in a child with cerebellar astrocytoma. 61
16970895 2006
47
MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images: is it useful for differentiation from medulloblastoma? 61
16550430 2006
48
Cerebellar pilocytic astrocytoma with auditory presentation: case study. 61
16417863 2005
49
[Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors]. 61
15981157 2005
50
Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults. 61
16245213 2005

Variations for Pilocytic Astrocytoma of Cerebellum

Expression for Pilocytic Astrocytoma of Cerebellum

Search GEO for disease gene expression data for Pilocytic Astrocytoma of Cerebellum.

Pathways for Pilocytic Astrocytoma of Cerebellum

Pathways related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.15 NF1 KIAA1549 FAM131B CLCN6 BRAF
2
Show member pathways
10.89 NF1 BRAF
3 10.4 H3C11 H3C10

GO Terms for Pilocytic Astrocytoma of Cerebellum

Cellular components related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear nucleosome GO:0000788 8.62 H3C11 H3C10

Biological processes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin silencing at rDNA GO:0000183 9.32 H3C11 H3C10
2 DNA replication-dependent nucleosome assembly GO:0006335 9.26 H3C11 H3C10
3 interleukin-7-mediated signaling pathway GO:0038111 9.16 H3C11 H3C10
4 telomere organization GO:0032200 8.96 H3C11 H3C10
5 regulation of gene silencing GO:0060968 8.62 H3C11 H3C10

Sources for Pilocytic Astrocytoma of Cerebellum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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