MCID: PLC004
MIFTS: 32

Pilocytic Astrocytoma of Cerebellum

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Pilocytic Astrocytoma of Cerebellum

MalaCards integrated aliases for Pilocytic Astrocytoma of Cerebellum:

Name: Pilocytic Astrocytoma of Cerebellum 12 15 74
Cerebellar Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4853
NCIt 51 C6809
UMLS 74 C0349620

Summaries for Pilocytic Astrocytoma of Cerebellum

MalaCards based summary : Pilocytic Astrocytoma of Cerebellum, also known as cerebellar pilocytic astrocytoma, is related to pleomorphic xanthoastrocytoma and pilocytic astrocytoma, and has symptoms including nausea and vomiting and headache. An important gene associated with Pilocytic Astrocytoma of Cerebellum is PNKP (Polynucleotide Kinase 3'-Phosphatase), and among its related pathways/superpathways are HIV Life Cycle and Ras signaling pathway. Affiliated tissues include cerebellum, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pilocytic Astrocytoma of Cerebellum

Diseases related to Pilocytic Astrocytoma of Cerebellum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 pleomorphic xanthoastrocytoma 30.5 BRAF IDH1
2 pilocytic astrocytoma 30.0 BRAF IDH1 KIAA1549 NF1
3 glioblastoma 28.9 BRAF IDH1 IDH2 MAPK3 NF1
4 astrocytoma 10.3
5 childhood oligodendroglioma 10.3 IDH1 KIAA1549
6 ganglioglioma 10.3
7 enchondroma 10.2 IDH1 IDH2
8 interval angle-closure glaucoma 10.2 IDH1 IDH2
9 intracranial chondrosarcoma 10.2 IDH1 IDH2
10 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
11 chondroblastic osteosarcoma 10.2 IDH1 IDH2
12 intraductal papilloma 10.2 IDH1 IDH2
13 spindle cell hemangioma 10.2 IDH1 IDH2
14 periosteal chondrosarcoma 10.2 IDH1 IDH2
15 glioma susceptibility 1 10.2 IDH1 IDH2
16 adult astrocytic tumour 10.2 IDH1 IDH2
17 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
18 drug-induced mental disorder 10.2 IDH1 IDH2
19 drug psychosis 10.2 IDH1 IDH2
20 undifferentiated pleomorphic sarcoma 10.2 IDH1 IDH2
21 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
22 neurofibromatosis, type i 10.1
23 neurofibromatosis, type iv, of riccardi 10.1
24 autism 10.1
25 thrombocytopenia 10.1
26 autism spectrum disorder 10.1
27 albright's hereditary osteodystrophy 10.1
28 meningitis 10.1
29 tremor 10.1
30 d-2-hydroxyglutaric aciduria 1 10.1 IDH1 IDH2
31 villous adenoma 10.1 BRAF GNAS
32 peripheral osteosarcoma 10.1 GNAS IDH1
33 bile duct adenocarcinoma 10.0 IDH1 IDH2
34 fibrillary astrocytoma 10.0 IDH1 IDH2 KIAA1549
35 enchondromatosis, multiple, ollier type 10.0 IDH1 IDH2
36 mucosal melanoma 10.0 BRAF NF1
37 leopard syndrome 10.0 BRAF NF1
38 pineal parenchymal tumor of intermediate differentiation 10.0 IDH1 NF1
39 brain stem glioma 10.0 BRAF IDH1 IDH2
40 myeloma, multiple 9.9 BRAF IDH1 IDH2
41 cerebellar astrocytoma 9.9 IDH1 KIAA1549 MARK3 PNKP
42 multiple enchondromatosis, maffucci type 9.9 GNAS IDH1 IDH2
43 cholangiocarcinoma 9.9 BRAF IDH1 IDH2
44 pilomyxoid astrocytoma 9.9 BRAF KIAA1549 NF1
45 adult oligodendroglioma 9.9 IDH1 IDH2 NF1
46 nervous system cancer 9.9 IDH1 IDH2 NF1
47 osteofibrous dysplasia 9.9 GNAS NF1
48 giant cell glioblastoma 9.8 BRAF IDH1
49 urachal adenocarcinoma 9.8 BRAF GNAS NF1
50 pulmonic stenosis 9.8 BRAF NF1

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma of Cerebellum:



Diseases related to Pilocytic Astrocytoma of Cerebellum

Symptoms & Phenotypes for Pilocytic Astrocytoma of Cerebellum

UMLS symptoms related to Pilocytic Astrocytoma of Cerebellum:


nausea and vomiting, headache

GenomeRNAi Phenotypes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.86 BRAF MARK3
2 Decreased viability GR00221-A-1 9.86 MARK3 NF1
3 Decreased viability GR00221-A-2 9.86 MARK3 NF1
4 Decreased viability GR00221-A-4 9.86 BRAF MAPK3 MARK3 NF1
5 Decreased viability GR00301-A 9.86 BRAF
6 Decreased viability GR00381-A-1 9.86 BRAF
7 Decreased viability GR00402-S-2 9.86 BRAF MAPK3 MARK3 NF1
8 Decreased cell migration GR00055-A-1 9.46 BRAF MAPK3 MARK3 NF1
9 Increased cell migration GR00055-A-3 8.92 BRAF MAPK3 MARK3 NF1

MGI Mouse Phenotypes related to Pilocytic Astrocytoma of Cerebellum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.86 BRAF GNAS IDH1 KIAA1549 MAPK3 MARK3
2 liver/biliary system MP:0005370 9.55 BRAF GNAS MAPK3 MARK3 NF1
3 neoplasm MP:0002006 9.35 BRAF GNAS IDH2 MAPK3 NF1
4 respiratory system MP:0005388 9.02 BRAF GNAS IDH1 MAPK3 NF1

Drugs & Therapeutics for Pilocytic Astrocytoma of Cerebellum

Search Clinical Trials , NIH Clinical Center for Pilocytic Astrocytoma of Cerebellum

Genetic Tests for Pilocytic Astrocytoma of Cerebellum

Anatomical Context for Pilocytic Astrocytoma of Cerebellum

MalaCards organs/tissues related to Pilocytic Astrocytoma of Cerebellum:

42
Cerebellum

Publications for Pilocytic Astrocytoma of Cerebellum

Articles related to Pilocytic Astrocytoma of Cerebellum:

# Title Authors Year
1
The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma. ( 30770993 )
2019
2
Solid non-enhancing cerebellar pilocytic astrocytoma case report. ( 30366781 )
2018
3
Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. ( 28503586 )
2015
4
Spontaneous anaplasia in pilocytic astrocytoma of cerebellum. ( 14565523 )
2003

Variations for Pilocytic Astrocytoma of Cerebellum

Expression for Pilocytic Astrocytoma of Cerebellum

Search GEO for disease gene expression data for Pilocytic Astrocytoma of Cerebellum.

Pathways for Pilocytic Astrocytoma of Cerebellum

Pathways related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 BRAF IDH1 KIAA1549 MAPK3 MARK3 NF1
2
Show member pathways
12.47 BRAF GNAS MAPK3 NF1
3
Show member pathways
12.43 BRAF GNAS MAPK3 NF1
4
Show member pathways
12.17 BRAF MAPK3 NF1
5
Show member pathways
12.15 BRAF GNAS MAPK3
6 12.08 BRAF GNAS MAPK3
7
Show member pathways
11.95 BRAF GNAS MAPK3
8 11.94 BRAF GNAS MAPK3
9 11.73 BRAF GNAS MAPK3
10 11.71 BRAF MAPK3 NF1
11 11.68 BRAF MAPK3 NF1
12 11.63 BRAF GNAS MAPK3
13 11.55 BRAF GNAS MAPK3
14 11.38 BRAF GNAS MAPK3
15 11.25 BRAF MAPK3
16
Show member pathways
11.25 BRAF MAPK3 MARK3
17 11.18 BRAF GNAS MAPK3
18 11.15 BRAF MAPK3 NF1
19
Show member pathways
11.15 BRAF KIAA1549 MAPK3 MARK3 NF1
20 11.11 MAPK3 NF1
21 11.11 BRAF GNAS MAPK3
22
Show member pathways
11.08 BRAF MAPK3
23 10.93 BRAF GNAS
24
Show member pathways
10.62 IDH1 IDH2
25 10.41 BRAF GNAS MAPK3

GO Terms for Pilocytic Astrocytoma of Cerebellum

Cellular components related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.02 BRAF IDH1 IDH2 MAPK3 PNKP

Biological processes related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.81 BRAF MAPK3 MARK3 PNKP
2 cognition GO:0050890 9.54 GNAS NF1
3 thymus development GO:0048538 9.52 BRAF MAPK3
4 positive regulation of telomerase activity GO:0051973 9.49 MAPK3 PNKP
5 positive regulation of telomere maintenance via telomerase GO:0032212 9.48 MAPK3 PNKP
6 tricarboxylic acid cycle GO:0006099 9.46 IDH1 IDH2
7 thyroid gland development GO:0030878 9.43 BRAF MAPK3
8 2-oxoglutarate metabolic process GO:0006103 9.4 IDH1 IDH2
9 face development GO:0060324 9.37 BRAF MAPK3
10 positive regulation of telomere capping GO:1904355 9.32 MAPK3 PNKP
11 NADP metabolic process GO:0006739 9.26 IDH1 IDH2
12 MAPK cascade GO:0000165 9.26 BRAF MAPK3 MARK3 NF1
13 isocitrate metabolic process GO:0006102 9.16 IDH1 IDH2
14 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Pilocytic Astrocytoma of Cerebellum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.56 BRAF MAPK3 MARK3 PNKP
2 NAD binding GO:0051287 9.32 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Pilocytic Astrocytoma of Cerebellum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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