MCID: PLM021
MIFTS: 46

Pilomyxoid Astrocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pilomyxoid Astrocytoma

MalaCards integrated aliases for Pilomyxoid Astrocytoma:

Name: Pilomyxoid Astrocytoma 12 59 15 73

Characteristics:

Orphanet epidemiological data:

59
pilomyxoid astrocytoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4845
NCIt 50 C40315
Orphanet 59 ORPHA251615
UMLS via Orphanet 74 C1519086
ICD10 via Orphanet 34 C71.9
UMLS 73 C1519086

Summaries for Pilomyxoid Astrocytoma

MalaCards based summary : Pilomyxoid Astrocytoma is related to pilocytic astrocytoma and glioma. An important gene associated with Pilomyxoid Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways/superpathways are ERK Signaling and Developmental Biology. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cerebellum and brain, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pilomyxoid Astrocytoma

Diseases related to Pilomyxoid Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 32.4 BRAF GFAP KIAA1549 KRAS NF1
2 glioma 30.1 BRAF FGFR1 H19 NF1
3 noonan syndrome 1 30.0 BRAF KRAS NF1 RAF1
4 astrocytoma 11.0
5 diencephalic syndrome 10.4
6 neurofibromatosis, type i 10.3
7 desmoplastic infantile ganglioglioma 10.3 GFAP SYP
8 extraventricular neurocytoma 10.3 GFAP SYP
9 lung combined type small cell carcinoma 10.3 GFAP SYP
10 cellular ependymoma 10.3 GFAP SYP
11 chordoid meningioma 10.2 GFAP SYP
12 central nervous system primitive neuroectodermal neoplasm 10.2 GFAP SYP
13 rhabdoid meningioma 10.2 BRAF GFAP
14 clear cell ependymoma 10.2 GFAP SYP
15 papillary tumor of the pineal region 10.2 BRAF SYP
16 chiari malformation 10.2 GFAP SYP
17 dysembryoplastic neuroepithelial tumor 10.2 GFAP SYP
18 hyperplastic polyposis syndrome 10.2 BRAF KRAS
19 cerebral neuroblastoma 10.2 GFAP SYP
20 benign glioma 10.2 GFAP KIAA1549 SYP
21 childhood oligodendroglioma 10.2 GFAP KIAA1549 SYP
22 tympanosclerosis 10.2 COL1A1 COL2A1
23 pleomorphic xanthoastrocytoma 10.2 BRAF GFAP SYP
24 gliofibroma 10.2 GFAP NF1
25 encephalocraniocutaneous lipomatosis 10.2 FGFR1 KRAS
26 synovial chondromatosis 10.2 COL1A1 COL2A1 FGFR1
27 ganglioglioma 10.2 BRAF GFAP SYP
28 lentigines 10.2 BRAF RAF1
29 syringocystadenoma papilliferum 10.2 BRAF GFAP KRAS
30 pulmonary large cell neuroendocrine carcinoma 10.1 NTRK2 SYP
31 bone development disease 10.1 COL1A1 COL2A1 FGFR1
32 malignant glandular tumor of peripheral nerve sheath 10.1 NF1 SYP
33 astroblastoma 10.1 GFAP SYP
34 rosette-forming glioneuronal tumor 10.1 FGFR1 SYP
35 respiratory system benign neoplasm 10.1 KRAS RAF1 SYP
36 hypertelorism 10.1 BRAF COL1A1 RAF1
37 williams-beuren syndrome 10.1
38 glioblastoma 10.1
39 pseudo-turner syndrome 10.1
40 angiocentric glioma 10.1
41 pituicytoma 10.1
42 adrenocortical carcinoma, hereditary 10.1 BRAF H19 SYP
43 lung benign neoplasm 10.1 KRAS RAF1 SYP
44 adult oligodendroglioma 10.1 FGFR1 NF1
45 ganglioneuroma 10.1 GFAP NTRK2 SYP
46 plexiform schwannoma 10.1 GFAP NF1
47 nervous system cancer 10.1 GFAP NF1 SYP
48 nodular medulloblastoma 10.1 GFAP SUFU
49 cerebellar liponeurocytoma 10.1 GFAP SUFU SYP
50 adult medulloblastoma 10.1 GFAP SUFU SYP

Graphical network of the top 20 diseases related to Pilomyxoid Astrocytoma:



Diseases related to Pilomyxoid Astrocytoma

Symptoms & Phenotypes for Pilomyxoid Astrocytoma

GenomeRNAi Phenotypes related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.32 KRAS
2 Decreased viability GR00106-A-0 10.32 KRAS
3 Decreased viability GR00221-A-1 10.32 FGFR1 KRAS NF1 NTRK2 RAF1
4 Decreased viability GR00221-A-2 10.32 FGFR1 KRAS NF1 NTRK2 RAF1
5 Decreased viability GR00221-A-4 10.32 NF1 NTRK2
6 Decreased viability GR00231-A 10.32 RAF1
7 Decreased viability GR00301-A 10.32 KRAS RAF1
8 Decreased viability GR00381-A-1 10.32 KRAS
9 Decreased viability GR00402-S-2 10.32 FGFR1 KRAS NF1 NTRK2 RAF1
10 Decreased cell migration GR00055-A-1 9.65 BRAF DOCK6 KRAS NF1 SRGAP3
11 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.46 BRAF FGFR1 NTRK2 RAF1
12 Increased cell migration GR00055-A-3 9.02 BRAF DOCK6 KRAS NF1 SRGAP3

MGI Mouse Phenotypes related to Pilomyxoid Astrocytoma:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 BRAF COL1A1 COL2A1 DACT2 FGFR1 GFAP
2 homeostasis/metabolism MP:0005376 10.34 BRAF COL1A1 COL2A1 DACT2 FGFR1 GFAP
3 cellular MP:0005384 10.27 BRAF COL1A1 COL2A1 DACT2 FGFR1 GFAP
4 immune system MP:0005387 10.25 BRAF COL1A1 COL2A1 DACT2 FGFR1 GFAP
5 cardiovascular system MP:0005385 10.24 BRAF COL1A1 COL2A1 FGFR1 GFAP KRAS
6 craniofacial MP:0005382 10.17 BRAF COL1A1 COL2A1 FGFR1 KRAS NF1
7 digestive/alimentary MP:0005381 10.16 BRAF COL1A1 COL2A1 FGFR1 GFAP KRAS
8 embryo MP:0005380 10.15 BRAF COL1A1 COL2A1 FGFR1 KRAS NF1
9 nervous system MP:0003631 10.15 BRAF COL1A1 COL2A1 FGFR1 GFAP KRAS
10 hearing/vestibular/ear MP:0005377 10.14 BRAF COL1A1 COL2A1 FGFR1 KRAS NF1
11 integument MP:0010771 10.1 BRAF COL1A1 DACT2 FGFR1 KRAS NF1
12 adipose tissue MP:0005375 10.08 BRAF COL1A1 COL2A1 KIAA1549 NTRK2 SUFU
13 liver/biliary system MP:0005370 10.06 BRAF COL1A1 COL2A1 KRAS NF1 NTRK2
14 normal MP:0002873 10.06 BRAF COL1A1 COL2A1 FGFR1 GFAP KRAS
15 limbs/digits/tail MP:0005371 10.02 BRAF COL1A1 COL2A1 FGFR1 KRAS NF1
16 muscle MP:0005369 9.98 BRAF COL1A1 FGFR1 GFAP KRAS NF1
17 neoplasm MP:0002006 9.88 BRAF COL1A1 KRAS NF1 RAF1 SUFU
18 respiratory system MP:0005388 9.76 BRAF COL1A1 COL2A1 KRAS NF1 NTRK2
19 pigmentation MP:0001186 9.65 BRAF COL1A1 KRAS NF1 SUFU
20 skeleton MP:0005390 9.61 BRAF COL1A1 COL2A1 FGFR1 KRAS NF1
21 vision/eye MP:0005391 9.32 BRAF COL1A1 COL2A1 FGFR1 GFAP KRAS

Drugs & Therapeutics for Pilomyxoid Astrocytoma

Drugs for Pilomyxoid Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4 Serotonin Agents Phase 3
5 Anti-Allergic Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Histamine H1 Antagonists Phase 3
8
Histamine Phosphate Phase 3 51-74-1 65513
9 Antipruritics Phase 3
10 Neurotransmitter Agents Phase 3,Not Applicable
11 Histamine Antagonists Phase 3
12 Gastrointestinal Agents Phase 3,Not Applicable
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Vincristine Approved, Investigational Phase 1, Phase 2 57-22-7, 2068-78-2 5978
15
Bevacizumab Approved, Investigational Phase 1, Phase 2,Phase 2 216974-75-3
16
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
17
Mebendazole Approved, Vet_approved Phase 1, Phase 2 31431-39-7 4030
18
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
19
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
20
Irinotecan Approved, Investigational Phase 1, Phase 2 100286-90-6, 97682-44-5 60838
21
Piperazine Approved, Vet_approved Phase 1, Phase 2 110-85-0 4837
22
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
23
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311
24 Anthelmintics Phase 1, Phase 2
25 Antineoplastic Agents, Alkylating Phase 1, Phase 2
26 Antiparasitic Agents Phase 1, Phase 2
27 Alkylating Agents Phase 1, Phase 2
28 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
29 Citrate Phase 1, Phase 2
30 topoisomerase I inhibitors Phase 1, Phase 2
31 Anti-Infective Agents Phase 1, Phase 2
32 Angiogenesis Modulating Agents Phase 1, Phase 2,Phase 2
33 Anticonvulsants Phase 1, Phase 2
34 Antimitotic Agents Phase 1, Phase 2
35 Topoisomerase Inhibitors Phase 1, Phase 2
36 Angiogenesis Inhibitors Phase 1, Phase 2,Phase 2
37 Piperazine citrate Phase 1, Phase 2
38
Verteporfin Approved, Investigational Phase 1 129497-78-5
39
Trioxsalen Approved Phase 1 3902-71-4 5585
40 Photosensitizing Agents Phase 1
41 Dihematoporphyrin Ether Phase 1
42
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
43 Dopamine Agents Not Applicable
44 Dihydroxyphenylalanine Not Applicable
45 Fluorides Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
3 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
4 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
5 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
6 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
7 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Pilomyxoid Astrocytoma

Genetic Tests for Pilomyxoid Astrocytoma

Anatomical Context for Pilomyxoid Astrocytoma

MalaCards organs/tissues related to Pilomyxoid Astrocytoma:

41
Spinal Cord, Cerebellum, Brain, Pineal, Lung, Bone, Colon

Publications for Pilomyxoid Astrocytoma

Articles related to Pilomyxoid Astrocytoma:

(show top 50) (show all 73)
# Title Authors Year
1
Intermediate Pilomyxoid Astrocytoma in the Cerebellum of a 5-Year-Old Boy. ( 29717569 )
2018
2
Pilocytic Astrocytoma with Gangliocytic Differentiation to Pilomyxoid Astrocytoma-expanding the Morphological Spectrum: Case Report and Literature Review. ( 30459892 )
2018
3
Posterior fossa pilomyxoid astrocytoma with spontaneous hemorrhage in pediatric patients. ( 28741227 )
2018
4
Fluorescence guided resection with 5-aminolevulinic acid of a pilomyxoid astrocytoma of the third ventricle. ( 28495088 )
2017
5
Bevacizumab Therapy for Pilomyxoid Astrocytoma. ( 28338567 )
2017
6
Pilomyxoid astrocytoma of the corpus callosum presenting with primary haemorrhage in an adolescent. ( 30363302 )
2017
7
Disseminated pilomyxoid astrocytoma in infancy with novel MUTYH mutation. ( 27797849 )
2016
8
Single-Agent Carboplatin for a Rare Case of Pilomyxoid Astrocytoma of the Spinal Cord in an Adult with Neurofibromatosis Type 1. ( 27920686 )
2016
9
Cytopathological features of pilomyxoid astrocytoma: a case report. ( 27018339 )
2016
10
Pilomyxoid astrocytoma in the adult cerebellum. ( 26777083 )
2016
11
Pilomyxoid astrocytoma involving the entire spinal cord in a newborn. ( 27106533 )
2016
12
Parietal pilomyxoid astrocytoma with recurrence in 10 months: A case report and review of literature. ( 27366287 )
2016
13
Spontaneous intratumoural and intraventricular haemorrhage associated with a pilomyxoid astrocytoma in the hypothalamic/chiasmatic region. ( 27450285 )
2016
14
Optic nerve pilomyxoid astrocytoma in a patient with Noonan syndrome. ( 25585602 )
2015
15
Cystic pilomyxoid astrocytoma on suprasellar region in 7-year-old girl: Treatment and strategy. ( 25972955 )
2015
16
Pilomyxoid Astrocytoma Occurring in the Third Ventricle. ( 26312139 )
2015
17
Pilomyxoid astrocytoma in an adult woman: Case report. ( 26458706 )
2015
18
Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. ( 25521223 )
2014
19
Pilomyxoid astrocytoma in an elderly patient: A case report and review of literature. ( 25387630 )
2014
20
Pilomyxoid astrocytoma presenting as diencephalic syndrome. ( 25672198 )
2014
21
Pilomyxoid astrocytoma treated successfully with vemurafenib. ( 24821190 )
2014
22
Pilomyxoid astrocytoma of the cerebellar vermis in an elderly patient. ( 24778917 )
2014
23
Pilomyxoid astrocytoma of the pineal region: Cytopathological features and differential diagnostic considerations by intraoperative smear preparation. ( 24578310 )
2014
24
Occurrence and distribution of pilomyxoid astrocytoma. ( 23281683 )
2013
25
Pediatric spinal pilomyxoid astrocytoma. ( 24053650 )
2013
26
Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome. ( 23042016 )
2013
27
Pilomyxoid astrocytoma of the cerebellum with Williams syndrome: a case report. ( 23604363 )
2013
28
Pilomyxoid astrocytoma of the brainstem. ( 23888217 )
2013
29
Primary pilomyxoid astrocytoma of the thoracolumbar spinal cord in an adult. ( 24441351 )
2013
30
Pilomyxoid astrocytoma with high proliferation index. ( 24470824 )
2013
31
Response. Pilomyxoid astrocytoma. ( 23767069 )
2013
32
Response. Pilomyxoid astrocytoma. ( 23767070 )
2013
33
Significance of radical resection for pilomyxoid astrocytoma of the cerebellum: a case report and review of the literature. ( 23503634 )
2013
34
Pilomyxoid astrocytoma. ( 23495811 )
2013
35
Insulin-like growth factor 2 mRNA binding protein 3 expression is an independent prognostic factor in pediatric pilocytic and pilomyxoid astrocytoma. ( 23584203 )
2013
36
Temporal and optic pathway pilomyxoid astrocytoma mimicking dural-based lesion: case report and review of the literature. ( 23548417 )
2012
37
Successful treatment of leptomeningeal gliomatosis of pilomyxoid astrocytoma after failed frontline chemotherapy. ( 22217612 )
2012
38
Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings. ( 23052462 )
2012
39
Intramedullary pilomyxoid astrocytoma with intracerebral metastasis exhibiting oligoden-droglioma-like features. ( 22826787 )
2012
40
T2 and DWI in pilocytic and pilomyxoid astrocytoma with pathologic correlation. ( 22728857 )
2012
41
Pilomyxoid astrocytoma in cerebellum. ( 23467810 )
2011
42
Pilomyxoid astrocytoma of the cervical spinal cord in a child with rapid progression into glioblastoma: case report and literature review. ( 20461521 )
2011
43
Diencephalic juvenile pilomyxoid astrocytoma with leptomeningeal dissemination. ( 21534206 )
2011
44
Pilomyxoid astrocytoma of the cerebellum. ( 21529196 )
2011
45
Pilomyxoid astrocytoma in unusual location in a child with neurofibromatosis type 1: case report and review of the literature. ( 20496528 )
2010
46
Pilomyxoid astrocytoma. ( 20551536 )
2010
47
Pilomyxoid astrocytoma of the cervical spinal cord successfully treated with chemotherapy: case report. ( 21030812 )
2010
48
Juvenile pilomyxoid astrocytoma in the opticohypothalamus. ( 21286484 )
2010
49
Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma. ( 19408090 )
2009
50
A case of pilomyxoid astrocytoma presenting with CSF rhinorrhoea in a 15-year-old. ( 19718549 )
2009

Variations for Pilomyxoid Astrocytoma

Copy number variations for Pilomyxoid Astrocytoma from CNVD:

7 (show all 14)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 38162 10 1 3000000 Gain DIP2C Pilomyxoid astrocytoma
2 97080 15 98500000 102531392 Loss LASS3 Pilomyxoid astrocytoma
3 121279 18 41800000 46400000 Microdeletion TCF4 Pilomyxoid astrocytoma
4 234564 8 136400000 146364022 Gain COL22A1 Pilomyxoid astrocytoma
5 234874 8 139900000 146364022 Gain CYHR1 Pilomyxoid astrocytoma
6 234879 8 139900000 146364022 Gain FOXH1 Pilomyxoid astrocytoma
7 234882 8 139900000 146364022 Gain GPT Pilomyxoid astrocytoma
8 234885 8 139900000 146364022 Gain KIFC2 Pilomyxoid astrocytoma
9 234887 8 139900000 146364022 Gain LRRC14 Pilomyxoid astrocytoma
10 234889 8 139900000 146364022 Gain LRRC24 Pilomyxoid astrocytoma
11 234891 8 139900000 146364022 Gain MFSD3 Pilomyxoid astrocytoma
12 234894 8 139900000 146364022 Gain PPP1R16A Pilomyxoid astrocytoma
13 234898 8 139900000 146364022 Gain RECQL4 Pilomyxoid astrocytoma
14 244901 9 1 2200000 Loss ANKRD15 Pilomyxoid astrocytoma

Expression for Pilomyxoid Astrocytoma

Search GEO for disease gene expression data for Pilomyxoid Astrocytoma.

Pathways for Pilomyxoid Astrocytoma

Pathways related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 BRAF COL1A1 COL2A1 FGFR1 GFAP HIST1H3B
2
Show member pathways
13.44 BRAF FGFR1 HIST1H3B KRAS NF1 RAF1
3
Show member pathways
12.89 COL1A1 COL2A1 FGFR1 KRAS NTRK2 RAF1
4
Show member pathways
12.83 BRAF COL1A1 COL2A1 KRAS RAF1
5
Show member pathways
12.8 BRAF COL1A1 COL2A1 FGFR1 KRAS NTRK2
6
Show member pathways
12.79 BRAF FGFR1 KRAS NTRK2 RAF1
7 12.77 BRAF FGFR1 KRAS RAF1 SUFU
8
Show member pathways
12.7 BRAF FGFR1 KRAS NF1 RAF1
9 12.53 GFAP NF1 NTRK2 SYP
10 12.47 BRAF FGFR1 KRAS NF1 NTRK2 RAF1
11
Show member pathways
12.44 BRAF FGFR1 KRAS RAF1
12
Show member pathways
12.38 BRAF FGFR1 KRAS NF1 NTRK2 RAF1
13
Show member pathways
12.33 BRAF KRAS NF1 RAF1
14
Show member pathways
12.33 BRAF FGFR1 KRAS NTRK2 RAF1
15
Show member pathways
12.21 BRAF KRAS NF1 RAF1
16 12.2 BRAF FGFR1 KRAS RAF1
17
Show member pathways
12.16 BRAF COL1A1 COL2A1 KRAS RAF1
18
Show member pathways
12.13 COL1A1 FGFR1 KRAS RAF1
19 12.04 FGFR1 KRAS NTRK2 RAF1
20
Show member pathways
12.02 BRAF FGFR1 KRAS NTRK2 RAF1
21 11.93 BRAF KRAS RAF1
22 11.89 BRAF FGFR1 RAF1
23 11.88 BRAF COL1A1 RAF1
24 11.86 COL2A1 FGFR1 GFAP
25 11.86 BRAF KRAS NF1 RAF1
26 11.84 BRAF KRAS NF1 RAF1
27 11.82 BRAF KRAS RAF1
28 11.72 FGFR1 GFAP SYP
29 11.68 BRAF KRAS RAF1
30 11.62 BRAF FGFR1 KRAS NTRK2 RAF1
31 11.61 FGFR1 KRAS RAF1
32
Show member pathways
11.6 BRAF KRAS RAF1
33
Show member pathways
11.58 BRAF NF1 RAF1
34 11.55 BRAF KRAS RAF1
35
Show member pathways
11.49 BRAF KIAA1549 KRAS NF1 RAF1
36 11.45 BRAF NF1 RAF1
37 11.42 KRAS NF1 RAF1
38
Show member pathways
11.38 BRAF FGFR1 KRAS RAF1
39 11.26 BRAF KRAS NTRK2
40 11.23 BRAF FGFR1 KRAS NTRK2 RAF1
41 11.08 BRAF KRAS RAF1
42 10.9 COL1A1 COL2A1 FGFR1 GFAP NTRK2 RAF1
43 10.82 NTRK2 RAF1
44 10.55 BRAF FGFR1 KRAS RAF1

GO Terms for Pilomyxoid Astrocytoma

Cellular components related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 BRAF COL1A1 COL2A1 DACT2 DOCK6 FGFR1

Biological processes related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.8 COL1A1 COL2A1 GFAP NF1
2 wound healing GO:0042060 9.71 COL1A1 NF1 RAF1
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.69 BRAF NTRK2 RAF1
4 visual learning GO:0008542 9.63 BRAF KRAS NF1
5 long-term synaptic potentiation GO:0060291 9.61 BRAF GFAP NTRK2
6 collagen fibril organization GO:0030199 9.58 COL1A1 COL2A1 NF1
7 face development GO:0060324 9.57 BRAF RAF1
8 myelination in peripheral nervous system GO:0022011 9.56 NF1 NTRK2
9 skeletal system development GO:0001501 9.56 COL1A1 COL2A1 FGFR1 SUFU
10 regulation of synaptic transmission, GABAergic GO:0032228 9.55 KRAS NF1
11 skeletal system morphogenesis GO:0048705 9.54 COL1A1 COL2A1 FGFR1
12 negative regulation of protein import into nucleus GO:0042308 9.52 NF1 SUFU
13 skin development GO:0043588 9.5 COL1A1 DACT2 SUFU
14 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.48 COL1A1 COL2A1
15 forebrain astrocyte development GO:0021897 9.16 KRAS NF1
16 regulation of long-term neuronal synaptic plasticity GO:0048169 9.13 KRAS NF1 SYP
17 MAPK cascade GO:0000165 9.02 BRAF FGFR1 KRAS NF1 RAF1

Molecular functions related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 BRAF COL1A1 COL2A1 FGFR1 GFAP RAF1
2 mitogen-activated protein kinase kinase binding GO:0031434 9.16 BRAF RAF1
3 platelet-derived growth factor binding GO:0048407 8.96 COL1A1 COL2A1

Sources for Pilomyxoid Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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