MCID: PLM021
MIFTS: 43

Pilomyxoid Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pilomyxoid Astrocytoma

MalaCards integrated aliases for Pilomyxoid Astrocytoma:

Name: Pilomyxoid Astrocytoma 12 58 15 71

Characteristics:

Orphanet epidemiological data:

58
pilomyxoid astrocytoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4845
NCIt 49 C40315
ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 72 C1519086
Orphanet 58 ORPHA251615
UMLS 71 C1519086

Summaries for Pilomyxoid Astrocytoma

MalaCards based summary : Pilomyxoid Astrocytoma is related to juvenile pilocytic astrocytoma and neurofibromatosis, type iv, of riccardi. An important gene associated with Pilomyxoid Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways/superpathways are ERK Signaling and Developmental Biology. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pilomyxoid Astrocytoma

Diseases related to Pilomyxoid Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 juvenile pilocytic astrocytoma 32.9 SYP NF1 LUC7L2 KRAS KIAA1549 IDH1
2 neurofibromatosis, type iv, of riccardi 31.4 NF1 KRAS KIAA1549
3 obstructive hydrocephalus 31.3 SYP NF1 GFAP
4 glioma 31.2 NF1 IDH1 H19 FGFR1 BRAF
5 angiocentric glioma 31.1 SYP IDH1 GFAP
6 benign ependymoma 31.0 SYP NF1 GFAP
7 anaplastic ependymoma 30.9 SYP GFAP
8 oligodendroglioma 30.6 SYP NTRK2 NF1 IDH1 GFAP FGFR1
9 glioblastoma multiforme 30.4 SYP RAF1 NF1 KRAS IDH1 H3-3B
10 childhood pilocytic astrocytoma 30.3 SRGAP3 SRGAP2 NF1 LUC7L2 KIAA1549 IDH1
11 astrocytoma 11.1
12 papillary ependymoma 10.7 SYP GFAP
13 lung combined type small cell carcinoma 10.7 SYP GFAP
14 cerebral neuroblastoma 10.7 SYP GFAP
15 cerebellopontine angle primitive neuroectodermal 10.6 SYP GFAP
16 papillary tumor of the pineal region 10.6 SYP BRAF
17 selection of therapeutic option in colorectal cancer 10.6 KRAS BRAF
18 chiari malformation 10.6 SYP GFAP
19 desmoplastic infantile ganglioglioma 10.6 SYP GFAP BRAF
20 posterior pituitary gland neoplasm 10.6 SYP GFAP
21 gangliocytoma 10.6 SYP KIAA1549 GFAP
22 enchondroma 10.6 IGF2BP3 IDH1
23 rhabdoid meningioma 10.6 SYP GFAP BRAF
24 ampulla of vater neoplasm 10.6 SYP KRAS
25 synovial chondromatosis 10.6 FGFR1 COL2A1 COL1A1
26 melanotic neuroectodermal tumor 10.6 SYP GFAP BRAF
27 hyperplastic polyposis syndrome 10.6 KRAS BRAF
28 pediatric meningioma 10.6 LUC7L2 KIAA1549
29 nodular ganglioneuroblastoma 10.6 SYP NTRK2
30 noonan syndrome and noonan-related syndrome 10.6 RAF1 BRAF
31 apocrine adenoma 10.6 KRAS BRAF
32 extraventricular neurocytoma 10.6 SYP IDH1 GFAP
33 subependymoma 10.6 SYP GFAP
34 cerebellar liponeurocytoma 10.6 SYP KIAA1549 FAM131B
35 rosette-forming glioneuronal tumor 10.6 SYP FGFR1
36 hydrocephalus 10.6
37 pineocytoma 10.6 SYP GFAP
38 tanycytic ependymoma 10.6 SYP IDH1 GFAP
39 syringocystadenoma papilliferum 10.6 KRAS GFAP BRAF
40 cranial nerve neoplasm 10.6 SYP NF1 GFAP
41 ganglioneuroma 10.6 SYP NTRK2 GFAP
42 optic nerve astrocytoma 10.6 SYP NF1
43 cystic teratoma 10.6 SYP KRAS GFAP
44 mature teratoma 10.6 SYP KRAS BRAF
45 optic nerve glioma 10.6 NF1 KIAA1549 GFAP
46 medullomyoblastoma 10.6 SYP GFAP
47 papillary craniopharyngioma 10.6 KIAA1549 FAM131B BRAF
48 appendix adenocarcinoma 10.6 SYP KRAS
49 frontal lobe neoplasm 10.6 SYP IDH1
50 respiratory system benign neoplasm 10.6 SYP RAF1 KRAS

Graphical network of the top 20 diseases related to Pilomyxoid Astrocytoma:



Diseases related to Pilomyxoid Astrocytoma

Symptoms & Phenotypes for Pilomyxoid Astrocytoma

GenomeRNAi Phenotypes related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.52 KRAS
2 Decreased viability GR00106-A-0 10.52 KRAS
3 Decreased viability GR00221-A-1 10.52 FGFR1 KRAS NF1 NTRK2 RAF1
4 Decreased viability GR00221-A-2 10.52 FGFR1 KRAS NF1 NTRK2 RAF1
5 Decreased viability GR00221-A-4 10.52 NF1 NTRK2
6 Decreased viability GR00231-A 10.52 RAF1
7 Decreased viability GR00301-A 10.52 KRAS RAF1
8 Decreased viability GR00381-A-1 10.52 KRAS
9 Decreased viability GR00402-S-2 10.52 FGFR1 KRAS NF1 NTRK2 RAF1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.85 FGFR1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.85 BRAF
12 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.85 FGFR1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.85 FGFR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.85 IDH1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.85 IDH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.85 IDH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.85 IDH1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.85 BRAF
19 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.85 SRGAP3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.85 BRAF
21 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 FGFR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.85 SRGAP3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.85 BRAF
24 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.85 FGFR1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.85 BRAF
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.85 SRGAP3
27 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.85 FGFR1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.85 BRAF
29 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.85 SRGAP3
30 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.85 BRAF
31 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.85 BRAF
32 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.85 SRGAP3
33 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.85 IDH1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.85 FGFR1 SRGAP3
35 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.85 BRAF FGFR1 IDH1 SRGAP3
36 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.85 FGFR1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.85 FGFR1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.85 SRGAP3
39 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.85 FGFR1
40 Increased cell migration GR00055-A-3 9.26 BRAF KRAS NF1 SRGAP3

MGI Mouse Phenotypes related to Pilomyxoid Astrocytoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 BRAF COL1A1 COL2A1 FGFR1 GFAP H3-3B
2 homeostasis/metabolism MP:0005376 10.3 BRAF COL1A1 COL2A1 DACT2 FGFR1 GFAP
3 cellular MP:0005384 10.25 BRAF COL1A1 COL2A1 DACT2 FGFR1 GFAP
4 mortality/aging MP:0010768 10.18 BRAF COL1A1 COL2A1 FGFR1 GFAP H3-3B
5 immune system MP:0005387 10.17 BRAF COL1A1 COL2A1 DACT2 FGFR1 GFAP
6 nervous system MP:0003631 10.1 BRAF COL1A1 COL2A1 FGFR1 GFAP KRAS
7 hearing/vestibular/ear MP:0005377 10.08 BRAF COL1A1 COL2A1 FGFR1 KRAS NF1
8 craniofacial MP:0005382 10.04 BRAF COL1A1 COL2A1 FGFR1 KRAS NF1
9 normal MP:0002873 10 BRAF COL1A1 COL2A1 FGFR1 GFAP H3-3B
10 liver/biliary system MP:0005370 9.95 BRAF COL1A1 COL2A1 KRAS NF1 NTRK2
11 respiratory system MP:0005388 9.76 BRAF COL1A1 COL2A1 IDH1 KRAS NF1
12 skeleton MP:0005390 9.61 BRAF COL1A1 COL2A1 FGFR1 IDH1 KRAS
13 vision/eye MP:0005391 9.28 BRAF COL1A1 COL2A1 FGFR1 GFAP KRAS

Drugs & Therapeutics for Pilomyxoid Astrocytoma

Drugs for Pilomyxoid Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Gastrointestinal Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Dermatologic Agents Phase 3
6 Antipruritics Phase 3
7 Histamine H1 Antagonists Phase 3
8 Serotonin Agents Phase 3
9 Histamine Antagonists Phase 3
10
Histamine Phosphate Phase 3 51-74-1 65513
11 Serotonin Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Piperazine Approved, Vet_approved Phase 1, Phase 2 110-85-0 4837
15
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
16
Mebendazole Approved, Vet_approved Phase 1, Phase 2 31431-39-7 4030
17
Sodium citrate Approved, Investigational Phase 1, Phase 2 68-04-2
18
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
19
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
20
Vincristine Approved, Investigational Phase 1, Phase 2 2068-78-2, 57-22-7 5978
21
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
22
Citric acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311
23 Piperazine citrate Phase 1, Phase 2
24 Alkylating Agents Phase 1, Phase 2
25 topoisomerase I inhibitors Phase 1, Phase 2
26 Angiogenesis Inhibitors Phase 1, Phase 2
27 Antineoplastic Agents, Immunological Phase 1, Phase 2
28 Anti-Infective Agents Phase 1, Phase 2
29 Antiparasitic Agents Phase 1, Phase 2
30 Citrate Phase 1, Phase 2
31 Topoisomerase Inhibitors Phase 1, Phase 2
32 Antimitotic Agents Phase 1, Phase 2
33 Anticonvulsants Phase 1, Phase 2
34 Anthelmintics Phase 1, Phase 2
35 DMP 777 Phase 1, Phase 2 157341-41-8
36
Verteporfin Approved, Investigational Phase 1 129497-78-5
37
Trioxsalen Approved Phase 1 3902-71-4 5585
38
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
39
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
40
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
41
Imetelstat Investigational Phase 1 868169-64-6
42 Photosensitizing Agents Phase 1
43 Dihematoporphyrin Ether Phase 1
44 Trace Elements Phase 1
45 Protein Kinase Inhibitors Phase 1
46 Vitamins Phase 1
47 Micronutrients Phase 1
48 Vitamin B3 Phase 1
49 Nutrients Phase 1
50 Vitamin B Complex Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
3 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
4 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium

Search NIH Clinical Center for Pilomyxoid Astrocytoma

Genetic Tests for Pilomyxoid Astrocytoma

Anatomical Context for Pilomyxoid Astrocytoma

MalaCards organs/tissues related to Pilomyxoid Astrocytoma:

40
Brain, Spinal Cord, Cerebellum, Bone, Lung, Eye, Skin

Publications for Pilomyxoid Astrocytoma

Articles related to Pilomyxoid Astrocytoma:

(show top 50) (show all 130)
# Title Authors PMID Year
1
Temporal lobe angiocentric glioma with oligodendroglioma-like areas: a rare association of an uncommon tumor. A case report with review of literature. 61
31897632 2020
2
Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. 61
31595628 2020
3
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors. 61
31435824 2019
4
Pilomyxoid astrocytomas: a short review. 61
30945015 2019
5
A comparison of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast MRI with and without contrast agent leakage correction in paediatric brain tumours. 61
30358415 2019
6
Thoracolumbar pilomyxoid astrocytoma concomitant with spinal scoliosis: A case report and literature review. 61
31893136 2019
7
Spinal Pilomyxoid Astrocytoma. 61
31593949 2019
8
Adult Pilomyxoid Astrocytoma with Hemorrhage in an Atypical Location. 61
30937060 2019
9
Pilocytic Astrocytoma with Gangliocytic Differentiation to Pilomyxoid Astrocytoma-expanding the Morphological Spectrum: Case Report and Literature Review. 61
30459892 2018
10
Endovascular glue embolization of a radiation-induced lenticulostriate artery pseudoaneurysm in a pediatric patient with optic pathway glioma: Case report and review of literature. 61
29848144 2018
11
Intermediate Pilomyxoid Astrocytoma in the Cerebellum of a 5-Year-Old Boy. 61
29717569 2018
12
Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome. 61
29433337 2018
13
A Comparative Immunohistochemical Study of Epithelial Membrane Antigen and NHERF1/EBP50 in the Diagnosis of Ependymomas. 61
27753657 2018
14
Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors. 61
29063957 2018
15
Posterior fossa pilomyxoid astrocytoma with spontaneous hemorrhage in pediatric patients. 61
28741227 2018
16
Fluorescence guided resection with 5-aminolevulinic acid of a pilomyxoid astrocytoma of the third ventricle. 61
28495088 2017
17
Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas. 61
28606795 2017
18
Characterization of gliomas: from morphology to molecules. 61
28674742 2017
19
Immunohistochemical Expression of Progesterone Receptors in Nonmeningothelial Central Nervous System Tumors. 61
26766127 2017
20
Bevacizumab Therapy for Pilomyxoid Astrocytoma. 61
28338567 2017
21
Cytopathological features of pilomyxoid astrocytoma: a case report. 61
27018339 2017
22
Prechiasmatic transection of the optic nerve in optic nerve glioma: technical description and surgical outcome. 61
27230830 2017
23
Pilomyxoid astrocytoma of the corpus callosum presenting with primary haemorrhage in an adolescent. 61
30363302 2017
24
Spontaneous intratumoural and intraventricular haemorrhage associated with a pilomyxoid astrocytoma in the hypothalamic/chiasmatic region. 61
27450285 2016
25
Disseminated pilomyxoid astrocytoma in infancy with novel MUTYH mutation. 61
27797849 2016
26
Pilomyxoid astrocytoma involving the entire spinal cord in a newborn. 61
27106533 2016
27
Single-Agent Carboplatin for a Rare Case of Pilomyxoid Astrocytoma of the Spinal Cord in an Adult with Neurofibromatosis Type 1. 61
27920686 2016
28
Parietal pilomyxoid astrocytoma with recurrence in 10 months: A case report and review of literature. 61
27366287 2016
29
Pilomyxoid astrocytoma in the adult cerebellum. 61
26777083 2016
30
A Case Series Characterizing Pilomyxoid Astrocytomas in Childhood. 61
26886222 2016
31
Heterogeneity of histopathological presentation of pilocytic astrocytoma - diagnostic pitfalls. A review. 61
27764513 2016
32
Pilomyxoid astrocytoma in an adult woman: Case report. 61
26458706 2015
33
Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. 61
25521223 2015
34
Optic nerve pilomyxoid astrocytoma in a patient with Noonan syndrome. 61
25585602 2015
35
Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma. 61
25748300 2015
36
Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas. 61
25666233 2015
37
High accuracy of arterial spin labeling perfusion imaging in differentiation of pilomyxoid from pilocytic astrocytoma. 61
25666232 2015
38
Cystic pilomyxoid astrocytoma on suprasellar region in 7-year-old girl: Treatment and strategy. 61
25972955 2015
39
Pilomyxoid astrocytoma of the pineal region: cytopathological features and differential diagnostic considerations by intraoperative smear preparation. 61
24578310 2015
40
Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma. 61
25883769 2015
41
Gliomas in the sellar turcica region: a retrospective study including adult cases and comparison with craniopharyngioma. 61
25531372 2015
42
Pilomyxoid Astrocytoma Occurring in the Third Ventricle. 61
26312139 2015
43
Pilomyxoid astrocytoma treated successfully with vemurafenib. 61
24821190 2014
44
Pilomyxoid astrocytoma presenting as diencephalic syndrome. 61
25672198 2014
45
Postnatal development of Blake's pouch cyst: a case report and new insight for its pathogenesis. 61
24907110 2014
46
Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. 61
24803676 2014
47
Pilomyxoid astrocytoma in an elderly patient: a case report and review of literature. 61
25387630 2014
48
Pilomyxoid astrocytoma of the cerebellar vermis in an elderly patient. 61
24778917 2014
49
The role of surgery in optic pathway/hypothalamic gliomas in children. 61
24138145 2014
50
Pediatric spinal pilomyxoid astrocytoma. 61
24053650 2013

Variations for Pilomyxoid Astrocytoma

Copy number variations for Pilomyxoid Astrocytoma from CNVD:

7 (show all 14)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 38162 10 1 3000000 Gain DIP2C Pilomyxoid astrocytoma
2 97080 15 98500000 102531392 Loss LASS3 Pilomyxoid astrocytoma
3 121279 18 41800000 46400000 Microdeletion TCF4 Pilomyxoid astrocytoma
4 234564 8 136400000 146364022 Gain COL22A1 Pilomyxoid astrocytoma
5 234874 8 139900000 146364022 Gain CYHR1 Pilomyxoid astrocytoma
6 234879 8 139900000 146364022 Gain FOXH1 Pilomyxoid astrocytoma
7 234882 8 139900000 146364022 Gain GPT Pilomyxoid astrocytoma
8 234885 8 139900000 146364022 Gain KIFC2 Pilomyxoid astrocytoma
9 234887 8 139900000 146364022 Gain LRRC14 Pilomyxoid astrocytoma
10 234889 8 139900000 146364022 Gain LRRC24 Pilomyxoid astrocytoma
11 234891 8 139900000 146364022 Gain MFSD3 Pilomyxoid astrocytoma
12 234894 8 139900000 146364022 Gain PPP1R16A Pilomyxoid astrocytoma
13 234898 8 139900000 146364022 Gain RECQL4 Pilomyxoid astrocytoma
14 244901 9 1 2200000 Loss ANKRD15 Pilomyxoid astrocytoma

Expression for Pilomyxoid Astrocytoma

Search GEO for disease gene expression data for Pilomyxoid Astrocytoma.

Pathways for Pilomyxoid Astrocytoma

Pathways related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 RAF1 NTRK2 NF1 KRAS H3-3B FGFR1
2
Show member pathways
13.44 SRGAP3 SRGAP2 RAF1 NF1 KRAS H3-3B
3
Show member pathways
12.9 RAF1 NTRK2 KRAS FGFR1 COL2A1 COL1A1
4
Show member pathways
12.89 RAF1 NTRK2 KRAS FGFR1 COL2A1 COL1A1
5
Show member pathways
12.81 RAF1 NTRK2 KRAS FGFR1 BRAF
6
Show member pathways
12.74 RAF1 KRAS COL2A1 COL1A1 BRAF
7
Show member pathways
12.6 RAF1 NF1 KRAS FGFR1 BRAF
8 12.55 RAF1 NTRK2 NF1 KRAS FGFR1 BRAF
9
Show member pathways
12.52 RAF1 NTRK2 COL2A1 COL1A1
10
Show member pathways
12.49 RAF1 NTRK2 NF1 KRAS FGFR1 BRAF
11
Show member pathways
12.34 RAF1 NF1 KRAS BRAF
12
Show member pathways
12.34 RAF1 NTRK2 KRAS FGFR1 BRAF
13
Show member pathways
12.23 RAF1 NF1 KRAS BRAF
14 12.17 SRGAP3 SRGAP2 RAF1 KRAS
15
Show member pathways
12.15 RAF1 KRAS FGFR1 COL1A1
16
Show member pathways
12.12 RAF1 NTRK2 KRAS FGFR1 BRAF
17 11.96 RAF1 KRAS FGFR1 COL1A1 BRAF
18 11.85 RAF1 NF1 KRAS BRAF
19 11.83 RAF1 KRAS BRAF
20 11.82 RAF1 NF1 KRAS BRAF
21 11.72 SYP GFAP FGFR1
22 11.68 RAF1 KRAS BRAF
23 11.66 RAF1 NTRK2 KRAS FGFR1 BRAF
24
Show member pathways
11.62 RAF1 KRAS BRAF
25 11.57 RAF1 KRAS BRAF
26
Show member pathways
11.54 RAF1 KRAS FGFR1 BRAF
27 11.47 RAF1 NF1 BRAF
28 11.43 RAF1 NF1 KRAS
29
Show member pathways
11.42 RAF1 NF1 BRAF
30 11.31 RAF1 KRAS BRAF
31 11.3 RAF1 KRAS IDH1 FGFR1
32
Show member pathways
11.23 RAF1 NF1 KRAS KIAA1549 FAM131B BRAF
33 11.22 NTRK2 KRAS BRAF
34 11.04 RAF1 KRAS BRAF
35 10.93 RAF1 NTRK2 GFAP FGFR1 COL2A1 COL1A1
36 10.89 RAF1 KRAS FGFR1 BRAF
37 10.81 RAF1 NTRK2

GO Terms for Pilomyxoid Astrocytoma

Cellular components related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 SRGAP3 SRGAP2 RAF1 NTRK2 NF1 KRAS

Biological processes related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.76 NF1 GFAP COL2A1 COL1A1
2 wound healing GO:0042060 9.69 RAF1 NF1 COL1A1
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.65 RAF1 NTRK2 BRAF
4 visual learning GO:0008542 9.58 NF1 KRAS BRAF
5 MAPK cascade GO:0000165 9.55 RAF1 NF1 KRAS FGFR1 BRAF
6 long-term synaptic potentiation GO:0060291 9.54 NTRK2 GFAP BRAF
7 collagen fibril organization GO:0030199 9.5 NF1 COL2A1 COL1A1
8 regulation of synaptic transmission, GABAergic GO:0032228 9.49 NF1 KRAS
9 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.43 COL2A1 COL1A1
10 skeletal system morphogenesis GO:0048705 9.43 FGFR1 COL2A1 COL1A1
11 forebrain astrocyte development GO:0021897 8.96 NF1 KRAS
12 regulation of long-term neuronal synaptic plasticity GO:0048169 8.8 SYP NF1 KRAS

Molecular functions related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.35 RAF1 NTRK2 KRAS FGFR1 BRAF
2 identical protein binding GO:0042802 9.28 SYP SRGAP2 RAF1 IDH1 GFAP FGFR1
3 mitogen-activated protein kinase kinase binding GO:0031434 9.26 RAF1 BRAF
4 platelet-derived growth factor binding GO:0048407 9.16 COL2A1 COL1A1

Sources for Pilomyxoid Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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