Aliases & Classifications for Pilonidal Sinus

MalaCards integrated aliases for Pilonidal Sinus:

Name: Pilonidal Sinus 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
pilonidal sinus:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 173000
MedGen 42 C0031925

Summaries for Pilonidal Sinus

MalaCards based summary : Pilonidal Sinus is related to squamous cell carcinoma and actinomycosis. An important gene associated with Pilonidal Sinus is CD4 (CD4 Molecule), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Phenol and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and eye, and related phenotypes are abnormality of the skin and pilonidal sinus

Description from OMIM: 173000

Related Diseases for Pilonidal Sinus

Graphical network of the top 20 diseases related to Pilonidal Sinus:



Diseases related to Pilonidal Sinus

Symptoms & Phenotypes for Pilonidal Sinus

Symptoms via clinical synopsis from OMIM:

57
Skin:
pilonidal sinus


Clinical features from OMIM:

173000

Human phenotypes related to Pilonidal Sinus:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the skin 32 HP:0000951
2 pilonidal sinus 32 HP:0010769

GenomeRNAi Phenotypes related to Pilonidal Sinus according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.62 IL2RA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.62 IL2RA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.62 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.62 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.62 CD4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.62 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.62 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.62 IL2RA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 CD4 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.62 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.62 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.62 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.62 CD4
14 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.62 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.62 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.62 CD4
18 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.62 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.62 IL2RA

Drugs & Therapeutics for Pilonidal Sinus

Drugs for Pilonidal Sinus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenol Approved, Experimental Phase 1,Not Applicable 108-95-2 996
2 Pharmaceutical Solutions Phase 1,Not Applicable
3 Anti-Infective Agents Phase 1,Not Applicable
4 Anti-Infective Agents, Local Phase 1,Not Applicable
5 Disinfectants Phase 1,Not Applicable
6 Anesthetics Phase 1,Not Applicable
7
Methylene blue Approved, Investigational Not Applicable 61-73-4
8
Povidone Approved Not Applicable 9003-39-8
9
Alginic acid Approved, Investigational Not Applicable 9005-32-7
10
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
11
Sulbactam Approved Not Applicable 68373-14-8
12
Ampicillin Approved, Vet_approved Not Applicable 69-53-4 6249
13
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
14
Clonidine Approved Not Applicable 4205-90-7 2803
15
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
16
Hydrogen peroxide Approved, Vet_approved Not Applicable 7722-84-1 784
17
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
18
Ornidazole Investigational Not Applicable 16773-42-5
19 Hemostatics Not Applicable
20 Mitogens Not Applicable
21 Radiation-Protective Agents Not Applicable
22 Calcium, Dietary Not Applicable
23 Coagulants Not Applicable
24 Protective Agents Not Applicable
25 Anti-Bacterial Agents Not Applicable
26 Clindamycin palmitate Not Applicable
27 Antibiotics, Antitubercular Not Applicable
28 Clindamycin phosphate Not Applicable
29 Anesthetics, Local Not Applicable
30 Retinol palmitate Not Applicable
31 Central Nervous System Depressants Not Applicable
32 Peripheral Nervous System Agents Not Applicable
33 retinol Not Applicable
34 Neurotransmitter Agents Not Applicable
35 Anti-Arrhythmia Agents Not Applicable
36 Adrenergic alpha-Agonists Not Applicable
37 Adrenergic Agents Not Applicable
38 Autonomic Agents Not Applicable
39 Diuretics, Potassium Sparing Not Applicable
40 Adrenergic alpha-2 Receptor Agonists Not Applicable
41 Sympatholytics Not Applicable
42 Analgesics Not Applicable
43 Antihypertensive Agents Not Applicable
44 Adrenergic Agonists Not Applicable
45 Sodium Channel Blockers Not Applicable

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Pilonidal Disease Wound Healing Study Unknown status NCT01857128 Phase 4
2 Karydakis Procedure Versus Excision With Healing by Secondary Intention (EHSI) in Sacrococcygeal Pilonidal Sinus Completed NCT00716937 Phase 4
3 Interest in the Use of Dressings With Honey for Wound Healing After Excision of Pilonidal Cyst Recruiting NCT02485860 Phase 4
4 Mid-line Excision Versus Karydakis Operation for Pilonidal Sinus Completed NCT00412659 Phase 2, Phase 3
5 Videoendoscopic Pilonidal Sinus Surgery Unknown status NCT01583751 Phase 1
6 Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol Completed NCT02277340 Phase 1
7 Ghnnam Excision Technique for Pilonidal Sinus Completed NCT01399320 Phase 1
8 Video Assisted Ablation of Pilonidal Sinus Unknown status NCT01963273 Not Applicable
9 Hardware Wound Healing In Surgical Treatment Of Sacrococcygeal Pilonidal Sinus Disease Unknown status NCT01876537 Not Applicable
10 Bascom Cleft Lift Versus Limberg Flap for Sacrococcygeal Pilonidal Sinus Unknown status NCT01337869 Not Applicable
11 Crystallized Phenol Versus Transposition Flaps for Treatment of Pilonidal Disease: A Prospective Study Unknown status NCT01792557 Not Applicable Crystallized phenol
12 Pore Excision, Curettage, and Injection of Cymetra for Pilonidal Disease Unknown status NCT00493493 Not Applicable
13 Feasibility of a Novel Technique for Pilonidal Wound Healing Unknown status NCT02330159
14 Open Wide Excision Versus Minimal Surgery for Pilonidal Disease Unknown status NCT01241136 Not Applicable
15 Karydakis Procedure Vs Limberg Flap in Treatment of Sacrococcygeal Pilonidal Sinus Completed NCT03765086 Not Applicable
16 Study on Surgical Treatment of Pilonidal Sinus Disease Completed NCT02849197
17 Effectiveness of Methylene Blue Guidance in Total Excision of Pilonidal Sinus. Completed NCT01513382 Not Applicable
18 Use of Plasma Rich in Growth Factors (PRGF) in Pilonidal Sinus Excision Completed NCT02246192 Not Applicable
19 Umbilical Pilonidal Sinus: a Case Report Completed NCT03007173
20 Treatment of Pilonidal Sinus Disease Using Surgiflo as a Sealant: A New Concept Completed NCT02638064 Not Applicable
21 Video Assisted Ablation of Pilonidal Sinus Versus Conventional Treatment Completed NCT02222298 Not Applicable
22 Limberg and Karydakis Flap in Recurrent Pilonidal Sinus Disease Completed NCT02287935 Not Applicable
23 Limberg-flap: Prospective Data Collection Completed NCT00672555 Not Applicable
24 Off-midline Closure Errors as a Risk Factor for Recurrence Following Limberg Flap in Patients With Pilonidal Sinus Completed NCT02663466
25 Pilonidal Sinus Disease: Preliminare Study Completed NCT03764657
26 Primary Wound Closure Using a Limberg Flap Versus Secondary Wound Healing Following Pilonidal Sinus Excision Completed NCT01889394 Not Applicable
27 Sorbact TM: Effect of a Microbial Binding Dressing on Wound Healing After Pilonidal Sinus Excision Completed NCT02011802 Not Applicable
28 Comparison Between Laying Open and Sinus Excision of Pilonidal Sinus - a Randomized Study Completed NCT00997048 Not Applicable
29 Modified Limberg Procedure Versus Lateral Advancement Flap With Burrow's Triangle Procedure in the Treatment of Pilonidal Sinus Completed NCT02116738 Not Applicable
30 Staging System for Chronic Symptomatic Pilonidal Sinus Disease Completed NCT02712970
31 Reduction Dead Space Volume With Karydakis Modification Completed NCT02574936 Not Applicable
32 Bilateral Gluteal Fascio-myo-cutaneous Flap in Treatment of Recurrent Pilonidal Disease Completed NCT02621879 Not Applicable
33 Asymmetric Primary Closure and Additional Skin Excision Technique. Completed NCT03424057 Not Applicable
34 Conservative Versus Surgical Treatment of Umbilical Pilonidal Disease Completed NCT01662765 Not Applicable
35 Comparison of Tension Free Primary Closure, Karydaks and Limberg Flap Methods Completed NCT02186964 Not Applicable
36 A Preliminary, Non-comparative Study to Evaluate a Bioresorbable Wound Scaffold in Acute Wounds Completed NCT01081522
37 Caudal Block,Saddle Block, Anorectal Surgery Completed NCT03498547 Not Applicable
38 Sacrococcygeal Local Anesthesia With Different Doses of Clonidine for Pilonidal Sinus Surgery Recruiting NCT02539693 Not Applicable Clonidine 75 µg/mL in sacrococcygeal block;Clonidine 150 µg/mL in sacrococcygeal block;Lidocaine
39 Alginate Dressings Versus Gauge Dressings After Pilonidal Cyst Resection: Examination of the Quality of Life Recruiting NCT03757572 Not Applicable
40 Non-Powered Negative Pressure Wound Therapy vs Open Technique for Pilonidal Disease Recruiting NCT03483480 Not Applicable
41 MIPE for Pilonidal Disease Recruiting NCT03772873
42 Excision and Reconstruction of the Natal Cleft With a Parasacral Perforator Flap Versus Open Excision With Secondary Healing, in the Management of Sacrococcygeal Pilonidal Disease. Active, not recruiting NCT03534700 Not Applicable
43 Minimally Invasive Treatment Methods for Pilonidal Disease Not yet recruiting NCT03070028 Not Applicable
44 De-roofing and Curettage vs WLE for Pilonidal Abscess Not yet recruiting NCT03415347 Not Applicable
45 Fistulectomy vs. Modified Karydakis Procedure for Pilonidal Sinus Terminated NCT03271996 Not Applicable
46 Rhomboid Flap Versus Primary Closure After Excision of Sacrococcygeal Pilonidal Sinus. (A Prospective Randomized Study) Withdrawn NCT01223599

Search NIH Clinical Center for Pilonidal Sinus

Genetic Tests for Pilonidal Sinus

Anatomical Context for Pilonidal Sinus

MalaCards organs/tissues related to Pilonidal Sinus:

41
Skin, Colon, Eye, T Cells

Publications for Pilonidal Sinus

Articles related to Pilonidal Sinus:

(show top 50) (show all 827)
# Title Authors Year
1
The V-Y flap technique in complicated and recurrent pilonidal sinus disease. ( 29629896 )
2018
2
The Hair in the Sinus: Sharp-Ended Rootless Head Hair Fragments can be Found in Large Amounts in Pilonidal Sinus Nests. ( 28639004 )
2018
3
Re: <i>JSLS</i>. 2017 Jul-Sep; 21(3): e2017.00043. DOI: 10.4293/JSLS.2017.00043. Endoscopic Pilonidal Sinus Treatment: Long-Term Results of a Prospective Series. ( 29765193 )
2018
4
Preliminary report on endoscopic pilonidal sinus treatment in children: results of a multicentric series. ( 29675752 )
2018
5
Long-term follow-up for pilonidal sinus surgery: AA review of literature with metanalysis. ( 29699781 )
2018
6
Recurrent Pilonidal Sinus Cyst on Penis. ( 29688739 )
2018
7
Endoscopic Pilonidal Sinus: How Far Have We Come? ( 29722734 )
2018
8
Evaluating a Surfactant-Containing Polymeric Membrane Foam Wound Dressing with Glycerin in Patients with Chronic Pilonidal Sinus Disease. ( 29923900 )
2018
9
Endoscopic pilonidal sinus treatment: a systematic review and meta-analysis. ( 29603009 )
2018
10
Use of Otoscope as a Diagnostic and Therapeutic Aid in Umbilical Pilonidal Sinus: A Novel Technique. ( 29643728 )
2018
11
Comparison between primary closure with Limberg Flap versus open procedure in treatment of pilonidal sinus, in terms of frequency of post-operative wound infection. ( 29643877 )
2018
12
Comparison of Unilateral Fasciocutaneous V-Y Flap Technique with Cleft Lift Procedure in the Treatment of Recurrent Pilonidal Sinus Disease: A Retrospective Clinical Study. ( 29397396 )
2018
13
Evaluating a Surfactant-Containing Polymeric Membrane Foam Wound Dressing with Glycerin in Patients with Chronic Pilonidal Sinus Disease. ( 29923905 )
2018
14
The effect of hair removal after surgery for sacrococcygeal pilonidal sinus disease: a systematic review of the literature. ( 29185064 )
2018
15
Evaluation of intradermal absorbable and mattress sutures to close pilonidal sinus wounds with Limberg flap: a prospective randomized comparative study. ( 29441338 )
2018
16
A useful alternative surgical technique to reconstructing large defects following excision of recurrent pilonidal sinus disease in the intergluteal region: An operative approach for the transverse lumbar artery perforator flap. ( 29781208 )
2018
17
Nonoperative management of pilonidal sinus disease: one more step toward the ideal management therapy-a randomized controlled trial. ( 29402447 )
2018
18
Limberg flap in management of pilonidal sinus disease: systematic review and a local experience. ( 29390948 )
2018
19
&amp;quot;Interdigital pilonidal sinus in a hairdresser&amp;quot; a case report. ( 29532975 )
2018
20
Endoscopic pilonidal sinus treatment versus total excision with primary closure for sacrococcygeal pilonidal sinus disease in the pediatric population. ( 29602548 )
2018
21
Outcomes of endoscopic pilonidal sinus treatment (EPSiT): a systematic review. ( 29850944 )
2018
22
Common surgical procedures in pilonidal sinus disease: A meta-analysis, merged data analysis, and comprehensive study on recurrence. ( 29449548 )
2018
23
Is conservative treatment an effective option for pilonidal sinus disease in children? ( 29947121 )
2018
24
A new minimally invasive treatment of pilonidal sinus disease with the use of a diode laser: a prospective large series of patients. ( 29878584 )
2018
25
Rare Location for Pilonidal Sinus: the Nasal Dorsum. ( 29762331 )
2018
26
A New Oval Advancement Flap Design for Reconstruction of Pilonidal Sinus Defect. ( 29713735 )
2018
27
A new surgical approach for pilonidal sinus disease: &amp;quot;de-epithelialization technique''. ( 29756106 )
2018
28
Pilonidal sinus disease surgery in children: the first study to compare crystallized phenol application to primary excision and closure. ( 28549686 )
2018
29
Concerns: M. Dessily, F. Charara, S. Ralea & J.-L. Allé.  Pilonidal sinus destruction with a radial laser probe: technique and first Belgian experience. Acta Chir Belg. 2017; 117(3): 164-168. ( 28608765 )
2018
30
Muzi's Tension Free Primary Closure of Pilonidal Sinus Disease: Updates on Long-Term Results on 514 Patients. ( 28752401 )
2018
31
Long term outcome of the Bascom cleft lift procedure for adolescent pilonidal sinus. ( 29223675 )
2018
32
The presence of occipital hair in the pilonidal sinus cavity-a triple approach to proof. ( 29488088 )
2018
33
Video-Assisted Subcutaneous Destruction of the Sinus Tract with Vessel-Loop Drainage as Minimally-Invasive Surgical Treatment for Pilonidal Sinus Disease. ( 29529705 )
2018
34
Karydakis flap reconstruction versus Limberg flap transposition for pilonidal sinus disease: a meta-analysis of randomized controlled trials. ( 30066108 )
2018
35
Inferiorly based lotus petal flap & laser therapy in difficult pilonidal sinus management. ( 30104141 )
2018
36
Excision of the Gluteal Cleft Pilonidal Sinus, Its Track, and the Sudoriferous Gland Area En-bloc with Primary Repair in the Management of this Disease. ( 30123728 )
2018
37
Comparison of limberg flap and oval flap techniques in sacrococcygeal pilonidal sinus disease surgery. ( 30216162 )
2018
38
Achieving the maximum by doing the minimum in the treatment of pilonidal sinus: where does evidence point? ( 30218628 )
2018
39
Idea and innovation: Secure fixation between dermis and periosteum using perforator flap to prevent recurrence of pilonidal sinus disease. ( 30240147 )
2018
40
Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children. ( 30268489 )
2018
41
Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease. ( 30413996 )
2018
42
Minimally Invasive Fibrin Sealant Application in Pilonidal Sinus: A Comparative Study. ( 30414361 )
2018
43
Management of sacrococcygeal pilonidal sinus disease. ( 30440104 )
2018
44
Treatment options for pilonidal sinus. ( 30489572 )
2018
45
Comparison of Primary Midline Closure, Limberg Flap, and Karydakis Flap Techniques in Pilonidal Sinus Surgery. ( 30531689 )
2018
46
Video-assisted ablation of pilonidal sinus (VAAPS) versus sinusectomy for treatment of chronic pilonidal sinus disease: a comparative study. ( 30542957 )
2018
47
Is histological analysis of pilonidal sinus useful? Retrospective analysis of 731 resections. ( 29146394 )
2017
48
Image Gallery: Pilonidal sinus of the penis. ( 29313935 )
2017
49
Which treatment modality for pediatric pilonidal sinus: Primary repair or secondaryA healing? ( 29042151 )
2017
50
Epidural abscess imitating recurrent pilonidal sinus: a case report. ( 29205143 )
2017

Variations for Pilonidal Sinus

Expression for Pilonidal Sinus

Search GEO for disease gene expression data for Pilonidal Sinus.

Pathways for Pilonidal Sinus

Pathways related to Pilonidal Sinus according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 CD4 IL2RA
2
Show member pathways
12.03 CD4 IL2RA
3
Show member pathways
11.97 CD4 IL2RA
4
Show member pathways
11.78 CD4 IL2RA
5
Show member pathways
11.47 CD4 IL2RA
6 11.43 CD4 IL2RA
7
Show member pathways
11.37 CD4 IL2RA
8 11.24 CD4 IL2RA
9 11.06 CD4 IL2RA
10 10.62 CD4 IL2RA
11 10.07 CD4 IL2RA

GO Terms for Pilonidal Sinus

Cellular components related to Pilonidal Sinus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.96 CD4 IL2RA
2 external side of plasma membrane GO:0009897 8.62 CD4 IL2RA

Biological processes related to Pilonidal Sinus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.32 CD4 IL2RA
2 immune response GO:0006955 9.26 CD4 IL2RA
3 cytokine-mediated signaling pathway GO:0019221 9.16 CD4 IL2RA
4 cell surface receptor signaling pathway GO:0007166 8.96 CD4 IL2RA
5 positive regulation of T cell proliferation GO:0042102 8.62 CD4 IL2RA

Sources for Pilonidal Sinus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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