Pilonidal Sinus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLN026 MIFTS: 35	Pilonidal Sinus
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Pilonidal Sinus

MalaCards integrated aliases for Pilonidal Sinus:

Name: Pilonidal Sinus ⁵⁷

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Inheritance:
autosomal dominant

HPO:

³¹

pilonidal sinus:
Inheritance autosomal dominant inheritance

External Ids:

OMIM® ⁵⁷ 173000

MedGen ⁴¹ C0031925

SNOMED-CT via HPO ⁶⁸ 199879009 263681008 47639008 more

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Summaries for Pilonidal Sinus

MalaCards based summary : Pilonidal Sinus is related to folliculitis and lymphadenitis. An important gene associated with Pilonidal Sinus is CD4 (CD4 Molecule), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Phenol and silver nitrate have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and endothelial, and related phenotypes are abnormality of the skin and pilonidal sinus

More information from OMIM: 173000

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Related Diseases for Pilonidal Sinus

Diseases related to Pilonidal Sinus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)

#	Related Disease	Score	Top Affiliating Genes
1	folliculitis	30.1	IL2RA CD4
2	lymphadenitis	29.6	IL2RA CD4
3	rapidly involuting congenital hemangioma	10.5
4	hidradenitis suppurativa	10.4
5	body mass index quantitative trait locus 1	10.4
6	hidradenitis	10.4
7	actinomycosis	10.4
8	squamous cell carcinoma	10.3
9	cystic teratoma	10.3
10	cellulitis	10.3
11	anal fistula	10.2
12	benign teratoma	10.2
13	mature teratoma	10.2
14	neural tube defects	10.2
15	osteomyelitis	10.2
16	skin disease	10.2
17	verrucous carcinoma	10.2
18	acne	10.2
19	chordoma	10.1
20	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	10.1
21	b-lymphoblastic leukemia/lymphoma	10.1
22	epidural abscess	10.1
23	balanoposthitis	10.1
24	impotence	10.1
25	teratoma	10.1
26	benign ependymoma	10.1
27	myxopapillary ependymoma	10.1
28	cellular ependymoma	10.1
29	meningitis	10.1
30	fasciitis	10.1
31	necrotizing fasciitis	10.1
32	47,xyy	10.1
33	tièche-jadassohn nevus	10.1
34	inflammatory myopathy with abundant macrophages	10.1
35	spondyloarthropathy 1	9.9
36	epidermoid cysts	9.9
37	hypertelorism	9.9
38	ige responsiveness, atopic	9.9
39	body mass index quantitative trait locus 11	9.9
40	body mass index quantitative trait locus 9	9.9
41	body mass index quantitative trait locus 8	9.9
42	polydactyly	9.9
43	late-onset retinal degeneration	9.9
44	body mass index quantitative trait locus 4	9.9
45	body mass index quantitative trait locus 10	9.9
46	anxiety	9.9
47	body mass index quantitative trait locus 7	9.9
48	body mass index quantitative trait locus 12	9.9
49	body mass index quantitative trait locus 14	9.9
50	leptin deficiency or dysfunction	9.9

Graphical network of the top 20 diseases related to Pilonidal Sinus:

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Symptoms & Phenotypes for Pilonidal Sinus

Human phenotypes related to Pilonidal Sinus:

³¹

#	Description	HPO Frequency	HPO Source Accession
1	abnormality of the skin ³¹		HP:0000951
2	pilonidal sinus ³¹		HP:0010769

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Skin:
pilonidal sinus

Clinical features from OMIM®:

173000 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Pilonidal Sinus according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-104	9.55	IL2RA
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.55	IL2RA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.55	IL2RA
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.55	IL2RA
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.55	IL2RA
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-14	9.55	CD4
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	9.55	CD4
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-160	9.55	CD4
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	9.55	IL2RA
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.55	CD4
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	9.55	IL2RA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.55	IL2RA
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.55	CD4
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-34	9.55	IL2RA
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.55	IL2RA
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	9.55	IL2RA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	9.55	IL2RA

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Drugs & Therapeutics for Pilonidal Sinus

Drugs for Pilonidal Sinus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Phenol

Approved, Experimental

Phase 4

108-95-2

996

silver nitrate

Approved, Investigational

Phase 4

7761-88-8

Pharmaceutical Solutions

Phase 4

Sclerosing Solutions

Phase 4

Anti-Infective Agents, Local

Phase 4

Anti-Infective Agents

Phase 4

Disinfectants

Phase 4

Metronidazole

Approved

Phase 2

443-48-1

4173

Titanium dioxide

Approved

Phase 2

13463-67-7

Petrolatum

Approved, Investigational

Phase 2

8009-03-8

Anti-Bacterial Agents

Phase 2

Antiparasitic Agents

Phase 2

Antiprotozoal Agents

Phase 2

Anesthetics

Phase 1

Methylene blue

Approved, Investigational

61-73-4

Povidone

Approved

9003-39-8

131751496

Hydrogen peroxide

Approved, Vet_approved

7722-84-1

784

Iodine

Approved, Investigational

7553-56-2

807

Clindamycin

Approved, Vet_approved

18323-44-9

29029

Ampicillin

Approved, Vet_approved

69-53-4

6249

Sulbactam

Approved

68373-14-8

Clonidine

Approved

4205-90-7

2803

Lidocaine

Approved, Vet_approved

137-58-6

3676

Bupivacaine

Approved, Investigational

2180-92-9, 38396-39-3

2474

Povidone-iodine

Approved

25655-41-8

Cadexomer iodine

Experimental

94820-09-4

Ornidazole

Investigational

16773-42-5

Mitogens

Antibiotics, Antitubercular

Clindamycin phosphate

Clindamycin palmitate

Coagulants

Surgiflo

Calcium, Dietary

Adrenergic alpha-Agonists

Anti-Arrhythmia Agents

Sodium Channel Blockers

Adrenergic Agents

Neurotransmitter Agents

Antihypertensive Agents

Sympatholytics

Anesthetics, Local

Diuretics, Potassium Sparing

Analgesics

Adrenergic Agonists

Hemostatics

Calcium

Nutraceutical

7440-70-2

271

Interventional clinical trials:

(show top 50) (show all 57)

#	Name	Status	NCT ID	Phase	Drugs
1	Recurrence, Complications, Work-off Date, Healing Time and Patients Willingness in Karydakis Technique for Treatment of Sacrococcygeal Pilonidal Sinus Versus Excision With Healing by Secondary Intention (EHSI)Technique	Completed	NCT00716937	Phase 4
2	Factors Affecting Outcomes of Crystallized Phenol Application in the Treatment of Pilonidal Sinus Disease	Recruiting	NCT04681443	Phase 4	Crystallized phenol application
3	Comparison of Phenol and Silver Nitrate Application in the Sacrococcygeal Pilonidal Sinus: A Prospective Randomized Controlled Study	Recruiting	NCT04560049	Phase 4	Silver Nitrate;Phenol
4	Interest in the Use of Dressings With Honey for Wound Healing After Excision of Pilonidal Cyst	Recruiting	NCT02485860	Phase 4
5	An Expertise-based Randomized Controlled Trial Comparing Midline Excision Versus Karydakis Operation at Surgery for Pilonidal Sinus	Completed	NCT00412659	Phase 2, Phase 3
6	Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds.	Not yet recruiting	NCT04273997	Phase 2	Metronidazole 10% ointment;Placebo ointment
7	Videoendoscopic Pilonidal Sinus Surgery. A New Technique	Unknown status	NCT01583751	Phase 1
8	Endoscopic Treatment of Pilonidal Sinus May Decrease the Recurrence After Crystallized Phenol Application	Completed	NCT02277340	Phase 1
9	Ghnnam Excision Technique for Pilonidal Sinus	Completed	NCT01399320	Phase 1
10	Randomized Controlled Trial of Non-Powered Negative Pressure Wound Therapy vs Open Technique for Pilonidal Disease	Unknown status	NCT03483480
11	Pore Excision, Curettage, and Injection of a Tissue Scaffold as Treatment for Pilonidal Disease	Unknown status	NCT00493493
12	Crystallized Phenol Application Versus Transposition Flaps for Treatment of Sacrococcygeal Pilonidal Disease: A Prospective Randomized Study	Unknown status	NCT01792557		Crystallized phenol
13	Comparison of Bascom Cleft Lift Technique Versus Limberg Flap Closure for Treatment of Sacrococcygeal Pilonidal Disease: A Prospective Randomized Controlled Trial Evaluating for Patient Satisfaction and Early Recurrence	Unknown status	NCT01337869
14	Video Assisted Ablation of Pilonidal Sinus. Evaluation of Safety and Efficacy of a New Minimally Invasive Technique	Unknown status	NCT01963273
15	A Feasibility Study of a Novel Technique for Pilonidal Wound Healing on Patient, Financial, and Quality of Life Outcomes	Unknown status	NCT02330159
16	De-roofing and Curettage Versus Wide Local Excision for the Treatment of Acute Pilonidal Abscess: A Randomised Controlled Trial	Unknown status	NCT03415347
17	Primary Wound Closure Using a Limberg Flap Versus Secondary Wound Healing Following Pilonidal Sinus Excision: Short-term Results of a Randomized Controlled Multicenter Trial	Completed	NCT01889394
18	Comparative Analysis of the Same technique-the Same Surgeon Approach in the Surgical Treatment of Pilonidal Sinus Disease: A Retrospective Cohort Study	Completed	NCT02849197
19	Effects of Reduction Dead Space Volume With Karydakis Modification	Completed	NCT02574936
20	A Novel Technique in the Treatment of Sacrococcygeal Pilonidal Sinus Disease: Effect of Reduction of Dead-space With Asymmetric Primary Closure and Additional Skin Excision Technique.	Completed	NCT03424057
21	Prospective Evaluation of Feasibility and Results of the Treatment of Pilonidal Sinus by Excision and Covering of the Defect With a Limberg-flap.	Completed	NCT00672555
22	Interventional Study of the Relatively New Surgical Techniques on the Treatment of Pilonidal Sinus Disease	Completed	NCT02116738
23	Importance of Erroneous Off-midline Closure as a Recurrence Factor in Limberg Flap Reconstruction in Sacrococcygeal Pilonidal Sinus: a Multicenter, Matched-case-control Study	Completed	NCT02663466
24	Randomised Prospective Comparison of Tension-free Primary Closure, Karydakis and Limberg Flap Methods in Treatment of Pilonidal Sinus Disease	Completed	NCT02186964
25	Karydakis Procedure Vs Limberg Flap in Treatment of Sacrococcygeal Pilonidal Sinus	Completed	NCT03765086
26	Lateral Advancement Adipo-Fascio-Cutaneous Flap Versus Classic Limberg Flap in The Treatment Of Non-Complicated Pilonidal Sinus: A Prospective Randomized Controlled Trial	Completed	NCT04572919
27	Does Intraoperative Methylene Blue Guidance in Pilonidal Sinus Surgery Really Effective in Total Excision of the Nest ?	Completed	NCT01513382
28	Phase 1 STRENGTHENING OF THE SACROCOCCYGEAL FASCIA IN THE SURGICAL TREATMENT OF PILONIDAL SINUS DISEASE	Completed	NCT01876537
29	Application of PRGF (Plasma Rich in Growth Factors) to Reduce the Healing Time After Pilonidal Sinus Excision. A Randomized 5-years Prospective Controlled Trial.	Completed	NCT02246192
30	Randomized Prospective Comparison of Crystallized Phenol and Platelet Rich Plasma Applications in Treatment of Pilonidal Sinus Disease	Completed	NCT03070028
31	Pilonidal Sinus Disease: Preliminary Case-control Study on Heat-related Wound Dehiscence	Completed	NCT03764657
32	Effectiveness of Limberg and Karydakis Flap in Recurrent Pilonidal Sinus Disease	Completed	NCT02287935
33	A Proposed Staging System for Chronic Symptomatic Pilonidal Sinus Disease and Results in Patients Treated With Stage-based Approach	Completed	NCT02712970
34	A Preliminary, Non-comparative Study to Evaluate a Bioresorbable Wound Scaffold in Acute Wounds	Completed	NCT01081522
35	Application of Platelet-rich Plasma for the Management of Pilonidal Sinus Disease: A Randomized Clinical Trial of Different Treatment Modalities	Completed	NCT04697082
36	Previously Operated Recurrent Pilonidal Sinus Treated With Crystallized Phenol: Twenty Years Experience	Completed	NCT04423510
37	Pilonidal Excision Versus Endoscopic Surgery	Completed	NCT03923621
38	Bilateral Gluteal Fascio-myo-cutaneous Advancement Flap in Treatment of Recurrent Sacrococcygeal Pilonidal Disease	Completed	NCT02621879
39	Video Assisted Ablation of Pilonidal Sinus Versus Convention Off-midline Bas Com Cleft Lift Procedure	Completed	NCT02222298
40	The Most Frequently Preferred Surgical Method In The Treatment Of Sacrococcygeal Pilonidal Disease; Multicenter Cohort Study	Completed	NCT04599517
41	Comparison Between Laying Open and Sinus Excision of Pilonidal Sinus - a Randomized Study	Completed	NCT00997048
42	Treatment of Pilonidal Sinus Disease Using Surgiflo as a Sealant: A New Concept	Completed	NCT02638064
43	Conservative Versus Surgical Treatment of Umbilical Pilonidal Sinus Disease: A Prospective, Randomised, and Multicenter Clinical Trial	Completed	NCT01662765
44	Combined Open and Closed Approach for Management of Pilonidal Sinus by Special U-shaped Sutures Without Drain.	Completed	NCT04017260
45	Assessment of the Effect of Platelet Rich Plasma on the Healing of Operated Sacrococcygeal Pilonidal Sinus by Open Method	Completed	NCT04430413
46	Umbilical Pilonidal Sinus: an Underestimated and Little-known Clinical Entity - Report of Two Cases	Completed	NCT03007173
47	Sorbact TM: Effect of a Microbial Binding Dressing on Wound Healing After Pilonidal Sinus Excision	Completed	NCT02011802
48	Routine Histological Analysis of Sacrococcygeal Pilonidal Sinus Specimens, Retrospective Analysis of 1971 Resections.	Completed	NCT04356768
49	Multicenter Randomized Controlled Trial of Mobilized Gluteus Maximus Muscle Fascia Flap Versus Primary Closure in the Treatment of Primary and Recurrent Pilonidal Sinus Disease.	Recruiting	NCT03914729
50	a Prospective, Randomized, Double-blind Study. comparıson of Karydakis Flap and Limberg Flap Treatment of Pilonidal Sinus in Adolescent. a Prospective, Randomised Study	Recruiting	NCT04217824

Search NIH Clinical Center for Pilonidal Sinus

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Genetic Tests for Pilonidal Sinus

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Anatomical Context for Pilonidal Sinus

MalaCards organs/tissues related to Pilonidal Sinus:

⁴⁰

Skin, Breast, Endothelial, Bone Marrow, Eye, Bone, T Cells

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Publications for Pilonidal Sinus

Articles related to Pilonidal Sinus:

(show top 50) (show all 1288)

#	Title	Authors	PMID	Year
1	Hereditary pilonidal sinus. ⁵⁷ ⁶¹	Holmes LB...Turner EA	5820262	1969
2	PILONIDAL SINUS: COCCYGEAL FISTULA. ⁵⁷ ⁶¹	Stone HB	17864995	1924
3	Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity. ⁶¹	Ozkur E...Alpsoy E	33030217	2021
4	The EPIC procedure (Endoscopic-assisted Pilonidal Irrigation and Cleaning): a simple and effective treatment for pilonidal disease. ⁶¹	Baxter J...Leinwand MJ	33721093	2021
5	Patient decision-making and regret in pilonidal sinus surgery: a mixed-methods study. ⁶¹	Strong E...PITSTOP Project Management Group, PITSTOP Collaborators	33645880	2021
6	Pilonidal sinus involving the breast in a man: A case report and literature review. ⁶¹	Shi R...Zhang XF	33761692	2021
7	A mapping review of sacrococcygeal pilonidal sinus disease. ⁶¹	Kumar M...Hind D	33728570	2021
8	Rethinking the causes of pilonidal sinus disease: a matched cohort study. ⁶¹	Doll D...Luedi MM	33737662	2021
9	Negative pressure-assisted endoscopic pilonidal sinus treatment. ⁶¹	Giordano P...Leo CA	33755853	2021
10	Cause of an acute abdomen never seen: Intraabdominal perforation of an umbilical pilonidal sinus abscess. ⁶¹	Mantoglu B...Kocbiyik A	33630288	2021
11	Pilonidal Sinus Disease: An Analysis of the Factors Affecting Recurrence. ⁶¹	Kanlioz M...Karatas T	33443913	2021
12	Pilonidal sinus of the cheek: an extremely rare clinical entity-case report and brief review of the literature. ⁶¹	Adhikari BN...Bhattarai A	33563340	2021
13	Pilonidal sinus disease of the penis: A case report and review of the literature. ⁶¹	Shanmugathas N...Minhas S	33099795	2021
14	Pilonidal Sinus Disease: Early Surgery and the Limberg Flap Improve Patient Outcomes. ⁶¹		33443909	2021
15	Early versus delayed endoscopic treatment of acute pilonidal abscess: a propensity score-matched analysis. ⁶¹	Manigrasso M...Milone M	33011845	2021
16	Is it Necessary to Perform a Histopathological Examination of Pilonidal Sinus Excision Material? ⁶¹	Akin T...Tez M	33517687	2021
17	Contrast-enhanced ultrasound with peroxide hydrogen for hidradenitis suppurativa and pilonidal sinus presurgical mapping. ⁶¹	Garcia-Martinez FJ...de Cabo Frances F	33428974	2021
18	Endoscopic Approach to Recurrent Pilonidal Sinus: A Retrospective Analysis. ⁶¹	Manigrasso M...Milone M	32678724	2021
19	SMILE technique for pilonidal sinus destruction with a radial laser probe-a video vignette. ⁶¹	Danys D...Poskus T	33415831	2021
20	Combined Horizontal Split Gluteus Maximus Muscle and Fasciocutaneous Limberg Flaps for Reconstruction of Recurrent Sacrococcygeal Pilonidal Sinus. ⁶¹	Ahmad MSI...Eltayeb H	33425568	2020
21	Pilonidal sinus: is histological examination necessary? ⁶¹	'Otutaha B...Hill AG	33369840	2020
22	[Wound Healing Disorders after Excision and Open Treatment for Pilonidal Sinus]. ⁶¹	Petersen S...Doll D	33336345	2020
23	Injection of freshly collected autologous adipose tissue into non-healing wounds after closed incision pilonidal surgery. ⁶¹	Haas S...Pedersen AG	32648140	2020
24	The epidemiology of hidradenitis suppurativa. ⁶¹	Ingram JR	32880911	2020
25	Hidradenitis Suppurativa: Proposal of Classification in Two Endotypes with Two-Step Cluster Analysis. ⁶¹	Gonzalez-Manso A...Vidal S	33171462	2020
26	Laser depilation as adjuvant therapy in prevention of recurrence of pilonidal sinus disease: initial experience of a district general hospital in the UK. ⁶¹	Liyanage A...Rajaganeshan R	32302208	2020
27	PILONIDAL SINUS MANAGEMENT: BASCOM FLAP VERSUS PILONIDAL PITS EXCISION, A SINGLE CENTER EXPERIENCE. ⁶¹	Imam A...Pelta A	33171038	2020
28	Endoscopic pilonidal sinus treatment: A minimally invasive surgical technique. ⁶¹	Azhough R...Jalali P	33185031	2020
29	Global Gender Differences in Pilonidal Sinus Disease: A Random-Effects Meta-Analysis. ⁶¹	Luedi MM...Doll D	32681319	2020
30	Use of Silver Nitrate Application as Mini-Invasive Treatment of Pilonidal Sinus Disease. ⁶¹	Kanat BH...Sacli A	33378636	2020
31	Outcomes of Two Treatments for Uncomplicated Pilonidal Sinus Disease: Karydakis Flap Procedure and Sinus Tract Ablation Procedure Using a 1,470 nm Diode Laser Combined With Pit Excision. ⁶¹	Yardimci VH	32064640	2020
32	Endoscopic pilonidal sinus resection (EPSI-R): a new method. ⁶¹	Yuksel BC...Er S	32458124	2020
33	Patient's preference should be given importance while deciding procedure to treat pilonidal sinus disease. ⁶¹	Garg P	33710726	2020
34	Treatment of young patients with pilonidal sinus disease with the original (unmodified) Limberg flap standardized for the first time. ⁶¹	Gezer HO...Temiz A	32353919	2020
35	Long-term outcomes of crystallized phenol application for the treatment of pilonidal sinus disease. ⁶¹	Dogru O...Ates D	32885705	2020
36	Limberg flap for the management of pilonidal sinus reduces disease recurrence compared to Karydakis and Bascom procedure: a systematic review and meta-analysis of randomized controlled trials. ⁶¹	Ray K...Sajid MS	32975384	2020
37	Primary Transverse Closure Compared to Open Wound Treatment for Primary Pilonidal Sinus Disease in Children. ⁶¹	Pfammatter M...Mayr J	33080769	2020
38	Complications And Recurrence After The Karydakis Flap Surgery. ⁶¹	Cakir M...Bicer M	33729169	2020
39	Postauricular Masses. ⁶¹	Tasli H...Karakoc O	32604279	2020
40	Assessment of the effect of platelet rich plasma on the healing of operated sacrococcygeal pilonidal sinus by lay-open technique: a randomized clinical trial. ⁶¹	Gohar MM...Nosair NA	32962673	2020
41	Fasciocutaneous Elliptical Rotation Flap for Pilonidal Sinus Disease and Its Outcomes. ⁶¹	Gundogdu E	33778388	2020
42	Turkey is leading in the 21st century pilonidal sinus disease research. ⁶¹	Doll D...Luedi MM	33778384	2020
43	Standardization of Pre- and Postoperative Management Using Laser Epilation and Oxygen-Enriched Oil-Based Gel Dressing in Pediatric Patients Undergoing Pediatric Endoscopic Pilonidal Sinus Treatment (PEPSiT). ⁶¹	Esposito C...Escolino M	32964496	2020
44	Pilonidal sinus disease: Review of current practice and prospects for endoscopic treatment. ⁶¹	Mahmood F...Akingboye A	32793341	2020
45	Risk factors of pilonidal sinus disease in preparatory school students; a case control study. ⁶¹	Faraj FH...Kakamad FH	32714525	2020
46	Surgical procedures in the pilonidal sinus disease: a systematic review and network meta-analysis. ⁶¹	Bi S...Gu J	32792519	2020
47	Effect of platelet-rich plasma on healing in laser pilonidoplasty for pilonidal sinus disease. ⁶¹	Kurt F...Kanat Z	32862404	2020
48	Limberg flap for pilonidal sinus disease - a video vignette. ⁶¹	Cheng S...Mantoo S	32065481	2020
49	Urachal Sinus Complicated by an Umbilical Abscess. ⁶¹	Almas T...Murad MF	32905066	2020
50	Conservative Sinusectomy vs. excision and primary off-midline closure for pilonidal disease: a randomized controlled trial. ⁶¹	Popeskou SG...Christoforidis D	32144531	2020

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Genes for Pilonidal Sinus

Genes related to Pilonidal Sinus (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CD4	CD4 Molecule	Protein Coding	7.06	GeneCards inferred via : Publications (show sections)
2	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	7.06	GeneCards inferred via : Publications (show sections)

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Variations for Pilonidal Sinus

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Expression for Pilonidal Sinus

Search GEO for disease gene expression data for Pilonidal Sinus.

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Pathways for Pilonidal Sinus

Pathways related to Pilonidal Sinus according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.24	IL2RA CD4
2	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.03	IL2RA CD4
3	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	11.99	IL2RA CD4
4	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	11.81	IL2RA CD4
5	Human T-cell leukemia virus 1 infection ³⁶	11.74	IL2RA CD4
6	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.43	IL2RA CD4
7	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.37	IL2RA CD4
8	Hematopoietic cell lineage ³⁶	11.25	IL2RA CD4
9	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.06	IL2RA CD4
10	Th2 Differentiation Pathway ⁶⁴	10.62	IL2RA CD4
11	IL12 signaling mediated by STAT4 ¹	10.07	IL2RA CD4

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GO Terms for Pilonidal Sinus

Cellular components related to Pilonidal Sinus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	8.96	IL2RA CD4
2	external side of plasma membrane	GO:0009897	8.62	IL2RA CD4

Biological processes related to Pilonidal Sinus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.26	IL2RA CD4
2	cell surface receptor signaling pathway	GO:0007166	9.16	IL2RA CD4
3	cytokine-mediated signaling pathway	GO:0019221	8.96	IL2RA CD4
4	positive regulation of T cell proliferation	GO:0042102	8.62	IL2RA CD4

Sources

Sources for Pilonidal Sinus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia