Pilonidal Sinus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLN026 MIFTS: 40	Pilonidal Sinus
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Pilonidal Sinus

MalaCards integrated aliases for Pilonidal Sinus:

Name: Pilonidal Sinus ⁵⁷

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal dominant

HPO:

³²

pilonidal sinus:
Inheritance autosomal dominant inheritance

External Ids:

OMIM ⁵⁷ 173000

MedGen ⁴² C0031925

SNOMED-CT via HPO ⁶⁹ 263681008 199879009 95320005 more

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Summaries for Pilonidal Sinus

MalaCards based summary : Pilonidal Sinus is related to squamous cell carcinoma and actinomycosis. An important gene associated with Pilonidal Sinus is CD4 (CD4 Molecule), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Phenol and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and eye, and related phenotypes are abnormality of the skin and pilonidal sinus

Description from OMIM: 173000

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Related Diseases for Pilonidal Sinus

Diseases related to Pilonidal Sinus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)

#	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	10.6
2	actinomycosis	10.2
3	neural tube defects	10.1
4	chordoma	10.1
5	body mass index quantitative trait locus 1	10.1
6	hidradenitis suppurativa	10.1
7	hidradenitis	10.1
8	verrucous carcinoma	10.1
9	myxopapillary ependymoma	10.1
10	ependymoma	10.1
11	tièche-jadassohn nevus	10.1
12	spondyloarthropathy 1	9.9
13	hypertelorism	9.9
14	rheumatoid arthritis	9.9
15	polydactyly	9.9
16	basal cell carcinoma 1	9.9
17	late-onset retinal degeneration	9.9
18	anxiety	9.9
19	anal fistula	9.9
20	arthritis	9.9
21	autoimmune pancreatitis	9.9
22	osteomyelitis	9.9
23	meningocele	9.9
24	disseminated intravascular coagulation	9.9
25	epidural abscess	9.9
26	toxic shock syndrome	9.9
27	impotence	9.9
28	basal cell carcinoma	9.9
29	pancreatitis	9.9
30	adenoma	9.9
31	spondylitis	9.9
32	septic arthritis	9.9
33	meningitis	9.9
34	fasciitis	9.9
35	necrotizing fasciitis	9.9
36	aortic coarctation	9.9
37	buschke lowenstein tumor	9.9
38	degos 'en cocarde' erythrokeratoderma	9.9
39	tethered cord syndrome	9.9
40	depression	9.9
41	adenohypophysitis	9.8	CD4 IL2RA
42	acquired immunodeficiency syndrome	9.8	CD4 IL2RA
43	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	9.7	CD4 IL2RA

Graphical network of the top 20 diseases related to Pilonidal Sinus:

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Symptoms & Phenotypes for Pilonidal Sinus

Symptoms via clinical synopsis from OMIM:

⁵⁷

Skin:
pilonidal sinus

Clinical features from OMIM:

173000

Human phenotypes related to Pilonidal Sinus:

³²

#	Description	HPO Frequency	HPO Source Accession
1	abnormality of the skin ³²		HP:0000951
2	pilonidal sinus ³²		HP:0010769

GenomeRNAi Phenotypes related to Pilonidal Sinus according to GeneCards Suite gene sharing:

²⁶ (show all 19)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.62	IL2RA
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.62	IL2RA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.62	IL2RA
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.62	IL2RA
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	9.62	CD4
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.62	IL2RA
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	9.62	IL2RA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	9.62	IL2RA
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.62	CD4 IL2RA
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	9.62	IL2RA
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	9.62	IL2RA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.62	IL2RA
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.62	CD4
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.62	IL2RA
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.62	IL2RA
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	9.62	IL2RA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-54	9.62	CD4
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	9.62	IL2RA
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.62	IL2RA

Sources

Drugs & Therapeutics for Pilonidal Sinus

Drugs for Pilonidal Sinus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Phenol

Approved, Experimental

Phase 1,Not Applicable

108-95-2

996

Pharmaceutical Solutions

Phase 1,Not Applicable

Anti-Infective Agents

Phase 1,Not Applicable

Anti-Infective Agents, Local

Phase 1,Not Applicable

Disinfectants

Phase 1,Not Applicable

Anesthetics

Phase 1,Not Applicable

Methylene blue

Approved, Investigational

Not Applicable

61-73-4

Povidone

Approved

Not Applicable

9003-39-8

Alginic acid

Approved, Investigational

Not Applicable

9005-32-7

Clindamycin

Approved, Vet_approved

Not Applicable

18323-44-9

29029

Sulbactam

Approved

Not Applicable

68373-14-8

Ampicillin

Approved, Vet_approved

Not Applicable

69-53-4

6249

Bupivacaine

Approved, Investigational

Not Applicable

2180-92-9, 38396-39-3

2474

Clonidine

Approved

Not Applicable

4205-90-7

2803

Lidocaine

Approved, Vet_approved

Not Applicable

137-58-6

3676

Hydrogen peroxide

Approved, Vet_approved

Not Applicable

7722-84-1

784

Vitamin A

Approved, Nutraceutical, Vet_approved

Not Applicable

11103-57-4, 68-26-8

445354

Ornidazole

Investigational

Not Applicable

16773-42-5

Hemostatics

Not Applicable

Mitogens

Not Applicable

Radiation-Protective Agents

Not Applicable

Calcium, Dietary

Not Applicable

Coagulants

Not Applicable

Protective Agents

Not Applicable

Anti-Bacterial Agents

Not Applicable

Clindamycin palmitate

Not Applicable

Antibiotics, Antitubercular

Not Applicable

Clindamycin phosphate

Not Applicable

Anesthetics, Local

Not Applicable

Retinol palmitate

Not Applicable

Central Nervous System Depressants

Not Applicable

Peripheral Nervous System Agents

Not Applicable

retinol

Not Applicable

Neurotransmitter Agents

Not Applicable

Anti-Arrhythmia Agents

Not Applicable

Adrenergic alpha-Agonists

Not Applicable

Adrenergic Agents

Not Applicable

Autonomic Agents

Not Applicable

Diuretics, Potassium Sparing

Not Applicable

Adrenergic alpha-2 Receptor Agonists

Not Applicable

Sympatholytics

Not Applicable

Analgesics

Not Applicable

Antihypertensive Agents

Not Applicable

Adrenergic Agonists

Not Applicable

Sodium Channel Blockers

Not Applicable

Interventional clinical trials:

(show all 46)

#	Name	Status	NCT ID	Phase	Drugs
1	Pilonidal Disease Wound Healing Study	Unknown status	NCT01857128	Phase 4
2	Karydakis Procedure Versus Excision With Healing by Secondary Intention (EHSI) in Sacrococcygeal Pilonidal Sinus	Completed	NCT00716937	Phase 4
3	Interest in the Use of Dressings With Honey for Wound Healing After Excision of Pilonidal Cyst	Recruiting	NCT02485860	Phase 4
4	Mid-line Excision Versus Karydakis Operation for Pilonidal Sinus	Completed	NCT00412659	Phase 2, Phase 3
5	Videoendoscopic Pilonidal Sinus Surgery	Unknown status	NCT01583751	Phase 1
6	Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol	Completed	NCT02277340	Phase 1
7	Ghnnam Excision Technique for Pilonidal Sinus	Completed	NCT01399320	Phase 1
8	Video Assisted Ablation of Pilonidal Sinus	Unknown status	NCT01963273	Not Applicable
9	Hardware Wound Healing In Surgical Treatment Of Sacrococcygeal Pilonidal Sinus Disease	Unknown status	NCT01876537	Not Applicable
10	Bascom Cleft Lift Versus Limberg Flap for Sacrococcygeal Pilonidal Sinus	Unknown status	NCT01337869	Not Applicable
11	Crystallized Phenol Versus Transposition Flaps for Treatment of Pilonidal Disease: A Prospective Study	Unknown status	NCT01792557	Not Applicable	Crystallized phenol
12	Pore Excision, Curettage, and Injection of Cymetra for Pilonidal Disease	Unknown status	NCT00493493	Not Applicable
13	Feasibility of a Novel Technique for Pilonidal Wound Healing	Unknown status	NCT02330159
14	Open Wide Excision Versus Minimal Surgery for Pilonidal Disease	Unknown status	NCT01241136	Not Applicable
15	Karydakis Procedure Vs Limberg Flap in Treatment of Sacrococcygeal Pilonidal Sinus	Completed	NCT03765086	Not Applicable
16	Study on Surgical Treatment of Pilonidal Sinus Disease	Completed	NCT02849197
17	Effectiveness of Methylene Blue Guidance in Total Excision of Pilonidal Sinus.	Completed	NCT01513382	Not Applicable
18	Use of Plasma Rich in Growth Factors (PRGF) in Pilonidal Sinus Excision	Completed	NCT02246192	Not Applicable
19	Umbilical Pilonidal Sinus: a Case Report	Completed	NCT03007173
20	Treatment of Pilonidal Sinus Disease Using Surgiflo as a Sealant: A New Concept	Completed	NCT02638064	Not Applicable
21	Video Assisted Ablation of Pilonidal Sinus Versus Conventional Treatment	Completed	NCT02222298	Not Applicable
22	Limberg and Karydakis Flap in Recurrent Pilonidal Sinus Disease	Completed	NCT02287935	Not Applicable
23	Limberg-flap: Prospective Data Collection	Completed	NCT00672555	Not Applicable
24	Off-midline Closure Errors as a Risk Factor for Recurrence Following Limberg Flap in Patients With Pilonidal Sinus	Completed	NCT02663466
25	Pilonidal Sinus Disease: Preliminare Study	Completed	NCT03764657
26	Primary Wound Closure Using a Limberg Flap Versus Secondary Wound Healing Following Pilonidal Sinus Excision	Completed	NCT01889394	Not Applicable
27	Sorbact TM: Effect of a Microbial Binding Dressing on Wound Healing After Pilonidal Sinus Excision	Completed	NCT02011802	Not Applicable
28	Comparison Between Laying Open and Sinus Excision of Pilonidal Sinus - a Randomized Study	Completed	NCT00997048	Not Applicable
29	Modified Limberg Procedure Versus Lateral Advancement Flap With Burrow's Triangle Procedure in the Treatment of Pilonidal Sinus	Completed	NCT02116738	Not Applicable
30	Staging System for Chronic Symptomatic Pilonidal Sinus Disease	Completed	NCT02712970
31	Reduction Dead Space Volume With Karydakis Modification	Completed	NCT02574936	Not Applicable
32	Bilateral Gluteal Fascio-myo-cutaneous Flap in Treatment of Recurrent Pilonidal Disease	Completed	NCT02621879	Not Applicable
33	Asymmetric Primary Closure and Additional Skin Excision Technique.	Completed	NCT03424057	Not Applicable
34	Conservative Versus Surgical Treatment of Umbilical Pilonidal Disease	Completed	NCT01662765	Not Applicable
35	Comparison of Tension Free Primary Closure, Karydaks and Limberg Flap Methods	Completed	NCT02186964	Not Applicable
36	A Preliminary, Non-comparative Study to Evaluate a Bioresorbable Wound Scaffold in Acute Wounds	Completed	NCT01081522
37	Caudal Block,Saddle Block, Anorectal Surgery	Completed	NCT03498547	Not Applicable
38	Sacrococcygeal Local Anesthesia With Different Doses of Clonidine for Pilonidal Sinus Surgery	Recruiting	NCT02539693	Not Applicable	Clonidine 75 µg/mL in sacrococcygeal block;Clonidine 150 µg/mL in sacrococcygeal block;Lidocaine
39	Alginate Dressings Versus Gauge Dressings After Pilonidal Cyst Resection: Examination of the Quality of Life	Recruiting	NCT03757572	Not Applicable
40	Non-Powered Negative Pressure Wound Therapy vs Open Technique for Pilonidal Disease	Recruiting	NCT03483480	Not Applicable
41	MIPE for Pilonidal Disease	Recruiting	NCT03772873
42	Excision and Reconstruction of the Natal Cleft With a Parasacral Perforator Flap Versus Open Excision With Secondary Healing, in the Management of Sacrococcygeal Pilonidal Disease.	Active, not recruiting	NCT03534700	Not Applicable
43	Minimally Invasive Treatment Methods for Pilonidal Disease	Not yet recruiting	NCT03070028	Not Applicable
44	De-roofing and Curettage vs WLE for Pilonidal Abscess	Not yet recruiting	NCT03415347	Not Applicable
45	Fistulectomy vs. Modified Karydakis Procedure for Pilonidal Sinus	Terminated	NCT03271996	Not Applicable
46	Rhomboid Flap Versus Primary Closure After Excision of Sacrococcygeal Pilonidal Sinus. (A Prospective Randomized Study)	Withdrawn	NCT01223599

Search NIH Clinical Center for Pilonidal Sinus

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Genetic Tests for Pilonidal Sinus

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Anatomical Context for Pilonidal Sinus

MalaCards organs/tissues related to Pilonidal Sinus:

⁴¹

Skin, Colon, Eye, T Cells

Sources

Publications for Pilonidal Sinus

Articles related to Pilonidal Sinus:

(show top 50) (show all 827)

#	Title	Authors	Year
1	The V-Y flap technique in complicated and recurrent pilonidal sinus disease. ( 29629896 )	Koca Y.S....Barut I.	2018
2	The Hair in the Sinus: Sharp-Ended Rootless Head Hair Fragments can be Found in Large Amounts in Pilonidal Sinus Nests. ( 28639004 )	Bosche F....Doll D.	2018
3	Re: <i>JSLS</i>. 2017 Jul-Sep; 21(3): e2017.00043. DOI: 10.4293/JSLS.2017.00043. Endoscopic Pilonidal Sinus Treatment: Long-Term Results of a Prospective Series. ( 29765193 )	Garg P.	2018
4	Preliminary report on endoscopic pilonidal sinus treatment in children: results of a multicentric series. ( 29675752 )	Pini Prato A....Meinero P.C.	2018
5	Long-term follow-up for pilonidal sinus surgery: AA review of literature with metanalysis. ( 29699781 )	Milone M....de Palma G.D.	2018
6	Recurrent Pilonidal Sinus Cyst on Penis. ( 29688739 )	Ercil H....Sozutek A.	2018
7	Endoscopic Pilonidal Sinus: How Far Have We Come? ( 29722734 )	Milone M....de Palma G.D.	2018
8	Evaluating a Surfactant-Containing Polymeric Membrane Foam Wound Dressing with Glycerin in Patients with Chronic Pilonidal Sinus Disease. ( 29923900 )	Sibbald R.G....Elliott J.A.	2018
9	Endoscopic pilonidal sinus treatment: a systematic review and meta-analysis. ( 29603009 )	Emile S.H....Wexner S.D.	2018
10	Use of Otoscope as a Diagnostic and Therapeutic Aid in Umbilical Pilonidal Sinus: A Novel Technique. ( 29643728 )	Huda F....Singh S.K.	2018
11	Comparison between primary closure with Limberg Flap versus open procedure in treatment of pilonidal sinus, in terms of frequency of post-operative wound infection. ( 29643877 )	Jabbar M.S....Puri N.	2018
12	Comparison of Unilateral Fasciocutaneous V-Y Flap Technique with Cleft Lift Procedure in the Treatment of Recurrent Pilonidal Sinus Disease: A Retrospective Clinical Study. ( 29397396 )	Koca Y.S....Barut A.^.	2018
13	Evaluating a Surfactant-Containing Polymeric Membrane Foam Wound Dressing with Glycerin in Patients with Chronic Pilonidal Sinus Disease. ( 29923905 )		2018
14	The effect of hair removal after surgery for sacrococcygeal pilonidal sinus disease: a systematic review of the literature. ( 29185064 )	Pronk A.A....Furnee E.J.B.	2018
15	Evaluation of intradermal absorbable and mattress sutures to close pilonidal sinus wounds with Limberg flap: a prospective randomized comparative study. ( 29441338 )	A8etin K....KaptanoA9lu L.	2018
16	A useful alternative surgical technique to reconstructing large defects following excision of recurrent pilonidal sinus disease in the intergluteal region: An operative approach for the transverse lumbar artery perforator flap. ( 29781208 )	Tan A.M....Mathur B.	2018
17	Nonoperative management of pilonidal sinus disease: one more step toward the ideal management therapy-a randomized controlled trial. ( 29402447 )		2018
18	Limberg flap in management of pilonidal sinus disease: systematic review and a local experience. ( 29390948 )		2018
19	&quot;Interdigital pilonidal sinus in a hairdresser&quot; a case report. ( 29532975 )		2018
20	Endoscopic pilonidal sinus treatment versus total excision with primary closure for sacrococcygeal pilonidal sinus disease in the pediatric population. ( 29602548 )		2018
21	Outcomes of endoscopic pilonidal sinus treatment (EPSiT): a systematic review. ( 29850944 )		2018
22	Common surgical procedures in pilonidal sinus disease: A meta-analysis, merged data analysis, and comprehensive study on recurrence. ( 29449548 )		2018
23	Is conservative treatment an effective option for pilonidal sinus disease in children? ( 29947121 )		2018
24	A new minimally invasive treatment of pilonidal sinus disease with the use of a diode laser: a prospective large series of patients. ( 29878584 )		2018
25	Rare Location for Pilonidal Sinus: the Nasal Dorsum. ( 29762331 )		2018
26	A New Oval Advancement Flap Design for Reconstruction of Pilonidal Sinus Defect. ( 29713735 )		2018
27	A new surgical approach for pilonidal sinus disease: &quot;de-epithelialization technique''. ( 29756106 )		2018
28	Pilonidal sinus disease surgery in children: the first study to compare crystallized phenol application to primary excision and closure. ( 28549686 )	Ates U...Yagmurlu A	2018
29	Concerns: M. Dessily, F. Charara, S. Ralea & J.-L. Allé. Pilonidal sinus destruction with a radial laser probe: technique and first Belgian experience. Acta Chir Belg. 2017; 117(3): 164-168. ( 28608765 )	Filippou DK	2018
30	Muzi's Tension Free Primary Closure of Pilonidal Sinus Disease: Updates on Long-Term Results on 514 Patients. ( 28752401 )	Muzi MG...Sileri P	2018
31	Long term outcome of the Bascom cleft lift procedure for adolescent pilonidal sinus. ( 29223675 )	Umesh V...Whyte C	2018
32	The presence of occipital hair in the pilonidal sinus cavity-a triple approach to proof. ( 29488088 )	Doll D...Luedi MM	2018
33	Video-Assisted Subcutaneous Destruction of the Sinus Tract with Vessel-Loop Drainage as Minimally-Invasive Surgical Treatment for Pilonidal Sinus Disease. ( 29529705 )	Korenkov M	2018
34	Karydakis flap reconstruction versus Limberg flap transposition for pilonidal sinus disease: a meta-analysis of randomized controlled trials. ( 30066108 )	Prassas D...Krieg A	2018
35	Inferiorly based lotus petal flap & laser therapy in difficult pilonidal sinus management. ( 30104141 )	Hamnett K...Iqbal A	2018
36	Excision of the Gluteal Cleft Pilonidal Sinus, Its Track, and the Sudoriferous Gland Area En-bloc with Primary Repair in the Management of this Disease. ( 30123728 )	Hamza M...Fatima N	2018
37	Comparison of limberg flap and oval flap techniques in sacrococcygeal pilonidal sinus disease surgery. ( 30216162 )	Karapolat B...K???kt?l? ?	2018
38	Achieving the maximum by doing the minimum in the treatment of pilonidal sinus: where does evidence point? ( 30218628 )	Garg P	2018
39	Idea and innovation: Secure fixation between dermis and periosteum using perforator flap to prevent recurrence of pilonidal sinus disease. ( 30240147 )	Liao LY...Chen HC	2018
40	Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children. ( 30268489 )	Hardy E...Quarmby JW	2018
41	Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease. ( 30413996 )	Sian TS...Lund JN	2018
42	Minimally Invasive Fibrin Sealant Application in Pilonidal Sinus: A Comparative Study. ( 30414361 )	Saedon M...Varma A	2018
43	Management of sacrococcygeal pilonidal sinus disease. ( 30440104 )	Harries RL...Harding KG	2018
44	Treatment options for pilonidal sinus. ( 30489572 )	Kober MM...Khachemoune A	2018
45	Comparison of Primary Midline Closure, Limberg Flap, and Karydakis Flap Techniques in Pilonidal Sinus Surgery. ( 30531689 )	Erkent M...Dolapc? M	2018
46	Video-assisted ablation of pilonidal sinus (VAAPS) versus sinusectomy for treatment of chronic pilonidal sinus disease: a comparative study. ( 30542957 )	Milone M...De Palma GD	2018
47	Is histological analysis of pilonidal sinus useful? Retrospective analysis of 731 resections. ( 29146394 )	Boulanger G....Comy M.	2017
48	Image Gallery: Pilonidal sinus of the penis. ( 29313935 )	Navarrete J....Agorio C.	2017
49	Which treatment modality for pediatric pilonidal sinus: Primary repair or secondaryA healing? ( 29042151 )	Ozcan R....Tekant G.T.	2017
50	Epidural abscess imitating recurrent pilonidal sinus: a case report. ( 29205143 )	Koutserimpas C....Velimezis G.	2017

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Genes for Pilonidal Sinus

Genes related to Pilonidal Sinus (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CD4	CD4 Molecule	Protein Coding	17.21	GeneCards inferred via : Publications (show sections)
2	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	17.21	GeneCards inferred via : Publications (show sections)

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Variations for Pilonidal Sinus

Sources

Expression for Pilonidal Sinus

Search GEO for disease gene expression data for Pilonidal Sinus.

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Pathways for Pilonidal Sinus

Pathways related to Pilonidal Sinus according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.23	CD4 IL2RA
2	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.03	CD4 IL2RA
3	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	11.97	CD4 IL2RA
4	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	11.78	CD4 IL2RA
5	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.47	CD4 IL2RA
6	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.43	CD4 IL2RA
7	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.37	CD4 IL2RA
8	Hematopoietic cell lineage ³⁷	11.24	CD4 IL2RA
9	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.06	CD4 IL2RA
10	Th2 Differentiation Pathway ⁶⁵	10.62	CD4 IL2RA
11	IL12 signaling mediated by STAT4 ¹	10.07	CD4 IL2RA

Sources

GO Terms for Pilonidal Sinus

Cellular components related to Pilonidal Sinus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	8.96	CD4 IL2RA
2	external side of plasma membrane	GO:0009897	8.62	CD4 IL2RA

Biological processes related to Pilonidal Sinus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	9.32	CD4 IL2RA
2	immune response	GO:0006955	9.26	CD4 IL2RA
3	cytokine-mediated signaling pathway	GO:0019221	9.16	CD4 IL2RA
4	cell surface receptor signaling pathway	GO:0007166	8.96	CD4 IL2RA
5	positive regulation of T cell proliferation	GO:0042102	8.62	CD4 IL2RA

Sources

Sources for Pilonidal Sinus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia