MCID: PNL014
MIFTS: 39

Pineal Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Pineal Gland Cancer

MalaCards integrated aliases for Pineal Gland Cancer:

Name: Pineal Gland Cancer 12 15
Tumor of the Pineal Region 12 73
Pinealoma 12 76
Malignant Neoplasm of Pineal Gland 73
Malignant Tumor of Pineal Gland 12
Malignant Pineal Region Tumor 12
Neoplasm of the Pineal Region 12
Neoplasm of Pineal Gland 12
Pineal Gland Neoplasm 73
Pineal Body Neoplasm 12
Pineocytic Tumor 12
Pineocytoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5032
ICD10 33 C75.3
ICD9CM 35 194.4
MeSH 44 D010871
SNOMED-CT 68 47598005 93962006

Summaries for Pineal Gland Cancer

Disease Ontology : 12 An endocrine gland located in the pineal gland located in the brain.

MalaCards based summary : Pineal Gland Cancer, also known as tumor of the pineal region, is related to papillary tumor of the pineal region and pineoblastoma. An important gene associated with Pineal Gland Cancer is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include pineal, brain and lung, and related phenotype is nervous system.

Wikipedia : 76 A pinealoma is a tumor of the pineal gland, a part of the brain that produces melatonin. If a pinealoma... more...

Related Diseases for Pineal Gland Cancer

Diseases related to Pineal Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 papillary tumor of the pineal region 34.4 ENO2 SYP
2 pineoblastoma 31.3 ASMT DICER1 GFAP SAG SYP
3 pineocytoma 31.2 ASMT ENO2 GFAP SAG SYP TUBB3
4 rhabdoid cancer 30.3 ENO2 SYP
5 atypical teratoid rhabdoid tumor 29.9 GFAP SYP
6 oncocytoma 29.8 KRT18 SYP
7 teratoma 29.7 ENO2 GFAP SYP
8 endodermal sinus tumor 10.4
9 ovarian carcinosarcoma 10.2 SYP TUBB3
10 carotid body cancer 10.2 ENO2 SYP
11 malignant sertoli cell tumor 10.2 ENO2 SYP
12 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
13 small cell carcinoma 10.2 ENO2 SYP
14 auditory system cancer 10.2 ENO2 SYP
15 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
16 gallbladder small cell carcinoma 10.2 ENO2 SYP
17 pancreatic somatostatinoma 10.2 ENO2 SYP
18 cutaneous ganglioneuroma 10.2 ENO2 SYP
19 extrahepatic bile duct adenocarcinoma 10.2 ENO2 SYP
20 small cell carcinoma of the bladder 10.2 ENO2 SYP
21 sensory organ benign neoplasm 10.2 ENO2 SYP
22 orbital cancer 10.2 ENO2 SYP
23 middle ear adenoma 10.2 ENO2 SYP
24 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
25 large cell neuroendocrine carcinoma 10.2 ENO2 SYP
26 atypical follicular adenoma 10.2 ENO2 SYP
27 chondroid chordoma 10.2 ENO2 TUBB3
28 cerebellum cancer 10.2 ENO2 SYP
29 cauda equina neoplasm 10.2 ENO2 SYP
30 endometrial small cell carcinoma 10.2 ENO2 SYP
31 extraosseous chondrosarcoma 10.2 ENO2 SYP
32 malignant teratoma 10.2 ENO2 SYP
33 odontoma 10.2 KRT18 TUBB3
34 autonomic nervous system benign neoplasm 10.2 ENO2 SYP
35 nodular ganglioneuroblastoma 10.2 ENO2 SYP
36 ganglioneuroblastoma 10.2 ENO2 SYP
37 angiomyoma 10.1 ENO2 SYP
38 gastric small cell carcinoma 10.1 ENO2 SYP
39 desmoplastic small round cell tumor 10.1 ENO2 SYP
40 carcinoid tumors, intestinal 10.1 ENO2 SYP
41 respiratory system benign neoplasm 10.1 ENO2 SYP
42 mucinous ovarian cystadenoma 10.1 ENO2 SYP
43 prostate small cell carcinoma 10.1 ENO2 SYP
44 bone benign neoplasm 10.1 ENO2 SYP
45 gastric squamous cell carcinoma 10.1 ENO2 SYP
46 meningeal melanomatosis 10.1 ENO2 SYP
47 extraskeletal ewing sarcoma 10.1 ENO2 SYP
48 panophthalmitis 10.1 SAG SYP
49 connective tissue benign neoplasm 10.1 ENO2 SYP
50 glomus tumor 10.1 ENO2 SYP

Comorbidity relations with Pineal Gland Cancer via Phenotypic Disease Network (PDN):


Obstructive Hydrocephalus

Graphical network of the top 20 diseases related to Pineal Gland Cancer:



Diseases related to Pineal Gland Cancer

Symptoms & Phenotypes for Pineal Gland Cancer

MGI Mouse Phenotypes related to Pineal Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 DICER1 ENO2 GFAP PTPRS SAG SYP

Drugs & Therapeutics for Pineal Gland Cancer

Search Clinical Trials , NIH Clinical Center for Pineal Gland Cancer

Genetic Tests for Pineal Gland Cancer

Anatomical Context for Pineal Gland Cancer

MalaCards organs/tissues related to Pineal Gland Cancer:

41
Pineal, Brain, Lung, Bone, Ovary, Cervix, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Pineal Gland Cancer:

19
The Pineal Gl

Publications for Pineal Gland Cancer

Articles related to Pineal Gland Cancer:

(show top 50) (show all 72)
# Title Authors Year
1
Papillary tumor of the pineal region: Case report and review of the literature. ( 29691144 )
2018
2
Papillary tumor of the pineal region in children: presentation of a case and comprehensive literature review. ( 29906576 )
2018
3
Papillary tumor of the pineal region accompanied by Parinaud's syndrome: magnetic resonance imaging findings. ( 29991845 )
2018
4
Recurrent Pineocytomalike Papillary Tumor of The Pineal Region: A Case Report and Literature Review. ( 30165231 )
2018
5
Durable response to mTOR inhibition in a patient with relapsing papillary tumor of the pineal region. ( 30295836 )
2018
6
Masson's tumor of the pineal region: case report. ( 28777021 )
2018
7
A Case of Nongerminomatous Germ Cell Tumor of the Pineal Region: Risks and Advantages of Biopsy by Endoscopic Approach. ( 29713348 )
2018
8
Nuclear CRX and FOXJ1 Expression Differentiates Non-Germ Cell Pineal Region Tumors and Supports the Ependymal Differentiation of Papillary Tumor of the Pineal Region. ( 28719464 )
2017
9
Papillary Tumor of the Pineal Region: A Distinct Molecular Entity. ( 26113311 )
2016
10
Late dissemination via cerebrospinal fluid of papillary tumor of the pineal region: a case report and literature review. ( 27179224 )
2016
11
Increased VEGF levels in one case of papillary tumor of the pineal region with intracranial haemorrhage at presentation: a potential surrogate indicator of tumor angiogenesis and aggressiveness? ( 26745494 )
2016
12
Cytologic features of papillary tumor of the pineal region: A case report showing tigroid background. ( 27535020 )
2016
13
A case of papillary tumor of the pineal region with a long clinical history: molecular characterization and therapeutic consideration with review of the literature. ( 27472995 )
2016
14
Atypical Teratoid/Rhabdoid Tumor of the Pineal Region in a Young Adult Male Patient: Case Report and Review of the Literature. ( 27144539 )
2016
15
Long-term follow-up of a papillary tumor of the pineal region: addendum to a case report. ( 27568037 )
2016
16
Papillary tumor of the pineal region with extended clinical and radiologic follow-up. ( 26539320 )
2015
17
Lack of BRAF-V600E Mutation in Papillary Tumor of the Pineal Region. ( 26125673 )
2015
18
Papillary tumor of the pineal region-report of three cases with literature review. ( 26238893 )
2015
19
Papillary tumor of the pineal region presenting with Foster Kennedy sign. ( 26183673 )
2015
20
Papillary tumor of the pineal region: A case report and review of the literature. ( 26622493 )
2015
21
Papillary tumor of the pineal region: Histopathological characterization and review of the literature. ( 24556386 )
2015
22
Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features. ( 26068071 )
2015
23
Outcomes After Surgery and Radiotherapy for Papillary Tumor of the Pineal Region. ( 25749579 )
2015
24
Papillary Tumor of the Pineal Region: MR Signal Intensity Correlated to Histopathology. ( 25688307 )
2015
25
Papillary tumor of the pineal region. Report of two cases and literature review. ( 25440015 )
2014
26
Stereotactic radiosurgery of a papillary tumor of the pineal region: case report and review of the literature. ( 23446182 )
2013
27
Bevacizumab is Effective for Recurrent Papillary Tumor of the Pineal Region: First Report. ( 24019784 )
2013
28
Papillary tumor of the pineal region with anaplastic small cell component. ( 23817812 )
2013
29
Papillary tumor of the pineal region: a case involving isocitrate dehydrogenase (IDH) genotyping. ( 22466620 )
2013
30
Early treatment response of a rare papillary tumor of the pineal region after primary proton-beam therapy using the raster-scanning technique at HIT. ( 23235766 )
2012
31
Complete regression of papillary tumor of the pineal region after radiation therapy: case report and review of the literature. ( 22086239 )
2012
32
Four-year clinical and neuroradiological follow-up of a papillary tumor of the pineal region. ( 22124853 )
2012
33
Papillary tumor of the pineal region. ( 22275792 )
2012
34
Papillary tumor of the pineal region: ultrastructural study of a case. ( 22292738 )
2012
35
Spinal metastasis of papillary tumor of the pineal region. ( 21109346 )
2011
36
Papillary tumor of the pineal region in a 15-month-old boy. ( 21529195 )
2011
37
Papillary tumor of the pineal region. ( 21629978 )
2011
38
Adjuvant temozolomide chemotherapy for treatment of papillary tumor of the pineal region. ( 21839968 )
2011
39
Papillary tumor of the pineal region: two case studies and a review of the literature. ( 21844577 )
2011
40
Atypical teratoid/rhabdoid tumor of the pineal region in an adult. ( 19911885 )
2010
41
Natural history of papillary tumor of the pineal region: new insights on biological explanation. ( 20454919 )
2010
42
Clinicopathological features from long-term observation of a papillary tumor of the pineal region (PTPR): a case report. ( 19856220 )
2009
43
Papillary tumor of the pineal region--a recently described entity: a report of three cases and review of the literature. ( 19642509 )
2009
44
Papillary tumor of the pineal region: report of a rapidly progressive tumor with possible multicentric origin. ( 19037636 )
2009
45
Neuroradiological follow-up of the growth of papillary tumor of the pineal region: a case report. ( 19517065 )
2009
46
Papillary tumor of the pineal region. ( 19667327 )
2009
47
Successful treatment of neoadjuvant therapy for papillary tumor of the pineal region. ( 19856218 )
2009
48
Papillary tumor of the pineal region of a dog. ( 19901302 )
2009
49
Papillary tumor of the pineal region: a case report. ( 18987834 )
2008
50
MR imaging of papillary tumor of the pineal region. ( 17925365 )
2008

Variations for Pineal Gland Cancer

Expression for Pineal Gland Cancer

Search GEO for disease gene expression data for Pineal Gland Cancer.

Pathways for Pineal Gland Cancer

Pathways related to Pineal Gland Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 ENO2 GFAP SAG SYP TUBB3
2
Show member pathways
11.17 GFAP KRT18 TUBB3

GO Terms for Pineal Gland Cancer

Cellular components related to Pineal Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.96 ENO2 SAG
2 integral component of synaptic vesicle membrane GO:0030285 8.62 PTPRS SYP

Sources for Pineal Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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