PPTID
MCID: PNL002
MIFTS: 22

Pineal Parenchymal Tumor of Intermediate Differentiation (PPTID)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Pineal Parenchymal Tumor of Intermediate Differentiation

MalaCards integrated aliases for Pineal Parenchymal Tumor of Intermediate Differentiation:

Name: Pineal Parenchymal Tumor of Intermediate Differentiation 12 15 17
Pineal Parenchymal Tumour of Intermediate Differentiation 12
Pineal Parenchymal Tumors of Intermediate Differentiation 20
Pptid 20

Classifications:



External Ids:

Disease Ontology 12 DOID:5030
NCIt 50 C6967
SNOMED-CT 67 715904005
UMLS 70 C1367859

Summaries for Pineal Parenchymal Tumor of Intermediate Differentiation

MalaCards based summary : Pineal Parenchymal Tumor of Intermediate Differentiation, also known as pineal parenchymal tumour of intermediate differentiation, is related to pineoblastoma and pineocytoma. An important gene associated with Pineal Parenchymal Tumor of Intermediate Differentiation is SYP (Synaptophysin). Affiliated tissues include pineal, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pineal Parenchymal Tumor of Intermediate Differentiation

Diseases related to Pineal Parenchymal Tumor of Intermediate Differentiation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 pineoblastoma 31.0 SYP KBTBD4 ASMT
2 pineocytoma 30.9 SYP ENO2 ASMT
3 papillary tumor of the pineal region 30.8 SYP ENO2
4 obstructive hydrocephalus 30.7 SYP ENO2
5 pineal gland cancer 29.6 SYP PTPRS KBTBD4 ENO2 ASMT
6 rare tumor 10.5
7 hydrocephalus 10.4
8 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
9 anal neuroendocrine tumor 10.3 SYP ENO2
10 optic nerve astrocytoma 10.3 SYP ENO2
11 cerebral neuroblastoma 10.3 SYP ENO2
12 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
13 lung meningioma 10.3 SYP ENO2
14 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
15 auditory system benign neoplasm 10.3 SYP ENO2
16 auditory system cancer 10.3 SYP ENO2
17 cloacogenic carcinoma 10.3 SYP ENO2
18 pineal region teratoma 10.3 SYP ENO2
19 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
20 cauda equina neoplasm 10.3 SYP ENO2
21 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
22 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
23 nodular prostate 10.3 SYP ENO2
24 ampulla of vater benign neoplasm 10.3 SYP ENO2
25 appendix carcinoid tumor 10.3 SYP ENO2
26 carotid body cancer 10.3 SYP ENO2
27 gallbladder small cell carcinoma 10.3 SYP ENO2
28 ureter small cell carcinoma 10.3 SYP ENO2
29 cerebellar liponeurocytoma 10.3 SYP ENO2
30 middle ear adenoma 10.3 SYP ENO2
31 cerebellopontine angle primitive neuroectodermal tumor 10.3 SYP ENO2
32 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP ENO2
33 gastric small cell carcinoma 10.3 SYP ENO2
34 extracranial neuroblastoma 10.3 SYP ENO2
35 jejunal neoplasm 10.3 SYP ENO2
36 frontal lobe neoplasm 10.3 SYP ENO2
37 sensory organ benign neoplasm 10.3 SYP ENO2
38 cervical neuroblastoma 10.3 SYP ENO2
39 ovarian large-cell neuroendocrine carcinoma 10.3 SYP ENO2
40 gastric hemangioma 10.3 SYP ENO2
41 subependymoma 10.3 SYP ENO2
42 myoblastoma 10.3 SYP ENO2
43 cutaneous ganglioneuroma 10.3 SYP ENO2
44 ganglioneuroma 10.3 SYP ENO2
45 kidney rhabdoid cancer 10.3 SYP ENO2
46 spinal cord oligodendroglioma 10.3 SYP ENO2
47 cervix small cell carcinoma 10.3 SYP ENO2
48 endobronchial leiomyoma 10.3 SYP ENO2
49 adrenal neuroblastoma 10.3 SYP ENO2
50 orbital cancer 10.3 SYP ENO2

Graphical network of the top 20 diseases related to Pineal Parenchymal Tumor of Intermediate Differentiation:



Diseases related to Pineal Parenchymal Tumor of Intermediate Differentiation

Symptoms & Phenotypes for Pineal Parenchymal Tumor of Intermediate Differentiation

GenomeRNAi Phenotypes related to Pineal Parenchymal Tumor of Intermediate Differentiation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 8.8 PPEF1 PPP6C
2 Decreased viability GR00402-S-2 8.8 PPEF1

Drugs & Therapeutics for Pineal Parenchymal Tumor of Intermediate Differentiation

Search Clinical Trials , NIH Clinical Center for Pineal Parenchymal Tumor of Intermediate Differentiation

Genetic Tests for Pineal Parenchymal Tumor of Intermediate Differentiation

Anatomical Context for Pineal Parenchymal Tumor of Intermediate Differentiation

MalaCards organs/tissues related to Pineal Parenchymal Tumor of Intermediate Differentiation:

40
Pineal

Publications for Pineal Parenchymal Tumor of Intermediate Differentiation

Articles related to Pineal Parenchymal Tumor of Intermediate Differentiation:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study. 61
33619588 2021
2
Pineal parenchymal tumor of intermediate differentiation: a single-institution experience. 61
33312675 2020
3
Role of Hypofractionated Stereotactic Radiosurgery in Recurrent Pineal Parenchymal Tumors of Intermediate Differentiation: A Case Report and Review of the Literature. 61
32944431 2020
4
Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations. 61
31768671 2020
5
Extent of Resection and Long-Term Survival of Pineal Region Tumors in Helsinki Neurosurgery. 61
31369883 2019
6
Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report. 61
31653819 2019
7
ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation. 61
31225581 2019
8
Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma. 61
30877433 2019
9
Primary pineal tumors - Unraveling histological challenges and certain clinical myths. 61
31085866 2019
10
Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation. 61
28800009 2019
11
Pineal region glioblastomas display features of diffuse midline and non-midline gliomas. 61
29992434 2018
12
Therapeutic strategy for pineal parenchymal tumor of intermediate differentiation (PPTID): case report of PPTID with malignant transformation to pineocytoma with leptomeningeal dissemination 6 years after surgery. 61
30028263 2018
13
Proton Magnetic Resonance Spectroscopy Detection of High Lipid Levels and Low Apparent Diffusion Coefficient Is Characteristic of Germinomas. 61
29274449 2018
14
Unedited microneurosurgery of a high-grade pineal parenchymal tumor of intermediate differentiation. 61
30603232 2018
15
Histology-Stratified Tumor Control and Patient Survival After Stereotactic Radiosurgery for Pineal Region Tumors: A Report From the International Gamma Knife Research Foundation. 61
28751141 2017
16
Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome. 61
27282397 2017
17
Patterns of care and survival outcomes in patients with pineal parenchymal tumor of intermediate differentiation: An individual patient data analysis. 61
27865543 2016
18
Revisiting the metastatic potential of childhood pineal parenchymal tumor of intermediate differentiation: a case report. 61
27226060 2016
19
[Pineal Parenchymal Tumor with Marked Cytologic Pleomorphism: Is there a Correlation with the Malignancy Grade?]. 61
27270146 2016
20
Twenty-seven cases of pineal parenchymal tumours of intermediate differentiation: mitotic count, Ki-67 labelling index and extent of resection predict prognosis. 61
25911570 2016
21
Integrated Genomic Characterization of a Pineal Parenchymal Tumor of Intermediate Differentiation. 61
26226092 2016
22
Pineal parenchymal tumours of intermediate differentiation - An evidence-based review of a new pathological entity. 61
26571134 2016
23
Are we over treating Pineal Parenchymal tumour with intermediate differentiation? Assessing the role of localised radiation therapy and literature review. 61
26788438 2016
24
Pineal parenchymal tumor of intermediate differentiation. 61
26549088 2015
25
Upfront Stereotactic Radiosurgery for Pineal Parenchymal Tumors in Adults. 61
26587186 2015
26
Pineal parenchymal tumours and pineal cysts. 61
24975206 2015
27
Imagery of pineal tumors. 61
25676911 2015
28
Late dural relapse of a resected and irradiated pineal parenchymal tumor of intermediate differentiation. 61
24887399 2014
29
Clinicopathologic study of pineal parenchymal tumors of intermediate differentiation. 61
23396072 2014
30
Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? 61
24510202 2014
31
Pineal parenchymal tumor of intermediate differentiation: Treatment outcomes of five cases. 61
24649332 2014
32
Spontaneous pineal apoplexy in a pineal parenchymal tumor of intermediate differentiation. 61
23691444 2013
33
Importance of initial aggressive treatment for pineal parenchymal tumor of intermediate differentiation: A case report and review of literature. 61
24674270 2013
34
Expression of O⁶-methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors. 61
22458700 2012
35
Pineal parenchymal tumor of intermediate differentiation with marked elevation of MIB-1 labeling index. 61
22362162 2012
36
Utility of Ki67 immunostaining in the grading of pineal parenchymal tumours: a multicentre study. 61
21696422 2012
37
Pineal parenchymal tumor of intermediate differentiation: imaging spectrum of an unusual tumor in 11 cases. 61
21080159 2011
38
Pineal parenchymal tumor of intermediate differentiation with papillary features: a continuum of primary pineal tumors? 61
20521161 2011
39
Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003--a single institution's experience. 61
21184689 2010
40
From the archives of the AFIP: lesions of the pineal region: radiologic-pathologic correlation. 61
21057132 2010
41
Histopathology of tumors of the pineal region. 61
20465391 2010
42
Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors. 61
20418777 2010
43
Pineal parenchymal tumor of intermediate differentiation: clinicopathological report and analysis of epidermal growth factor receptor variant III expression. 61
20404701 2010
44
Pineal parenchymal tumor of intermediate differentiation showing malignant progression at relapse. 61
19170892 2009
45
Pathology of pineal parenchymal tumors. 61
19329858 2009
46
Cytologic feature by squash preparation of pineal parenchyma tumor of intermediate differentiation. 61
18773448 2008
47
Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. 61
18371183 2008
48
Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. 61
18266015 2008
49
Postoperative adjuvant treatment for pineal parenchymal tumour of intermediate differentiation. 61
16904896 2006
50
Pineal parenchymal tumor of intermediate differentiation with cytologic pleomorphism. 61
16771177 2006

Variations for Pineal Parenchymal Tumor of Intermediate Differentiation

Expression for Pineal Parenchymal Tumor of Intermediate Differentiation

Search GEO for disease gene expression data for Pineal Parenchymal Tumor of Intermediate Differentiation.

Pathways for Pineal Parenchymal Tumor of Intermediate Differentiation

GO Terms for Pineal Parenchymal Tumor of Intermediate Differentiation

Cellular components related to Pineal Parenchymal Tumor of Intermediate Differentiation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of synaptic vesicle membrane GO:0030285 8.62 SYP PTPRS

Biological processes related to Pineal Parenchymal Tumor of Intermediate Differentiation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dephosphorylation GO:0006470 8.8 PTPRS PPP6C PPEF1

Molecular functions related to Pineal Parenchymal Tumor of Intermediate Differentiation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoprotein phosphatase activity GO:0004721 8.8 PTPRS PPP6C PPEF1

Sources for Pineal Parenchymal Tumor of Intermediate Differentiation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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