MCID: PNL002
MIFTS: 30

Pineal Parenchymal Tumor of Intermediate Differentiation

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Pineal Parenchymal Tumor of Intermediate Differentiation

MalaCards integrated aliases for Pineal Parenchymal Tumor of Intermediate Differentiation:

Name: Pineal Parenchymal Tumor of Intermediate Differentiation 12 15
Pineal Parenchymal Tumour of Intermediate Differentiation 12
Pineal Parenchymal Tumors of Intermediate Differentiation 53
Pptid 53

Classifications:



External Ids:

Disease Ontology 12 DOID:5030
NCIt 50 C6967
SNOMED-CT 68 31671006 397379005
UMLS 73 C1367859

Summaries for Pineal Parenchymal Tumor of Intermediate Differentiation

MalaCards based summary : Pineal Parenchymal Tumor of Intermediate Differentiation, also known as pineal parenchymal tumour of intermediate differentiation, is related to pineocytoma and ureter small cell carcinoma. An important gene associated with Pineal Parenchymal Tumor of Intermediate Differentiation is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Phototransduction. Affiliated tissues include pineal and brain.

Related Diseases for Pineal Parenchymal Tumor of Intermediate Differentiation

Diseases related to Pineal Parenchymal Tumor of Intermediate Differentiation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 pineocytoma 29.1 ASMT ENO2 RHO SAG SYP TUBB3
2 ureter small cell carcinoma 11.0 ENO2 SYP
3 malignant sertoli cell tumor 11.0 ENO2 SYP
4 urinary bladder small cell neuroendocrine carcinoma 11.0 ENO2 SYP
5 auditory system cancer 11.0 ENO2 SYP
6 sinonasal undifferentiated carcinoma 11.0 ENO2 SYP
7 sensory organ benign neoplasm 11.0 ENO2 SYP
8 gallbladder small cell carcinoma 11.0 ENO2 SYP
9 pancreatic somatostatinoma 11.0 ENO2 SYP
10 cutaneous ganglioneuroma 11.0 ENO2 SYP
11 extrahepatic bile duct adenocarcinoma 11.0 ENO2 SYP
12 small cell carcinoma of the bladder 11.0 ENO2 SYP
13 papillary tumor of the pineal region 11.0 ENO2 SYP
14 orbital cancer 10.9 ENO2 SYP
15 middle ear adenoma 10.9 ENO2 SYP
16 pulmonary large cell neuroendocrine carcinoma 10.9 ENO2 SYP
17 atypical follicular adenoma 10.9 ENO2 SYP
18 central nervous system primitive neuroectodermal neoplasm 10.9 ENO2 SYP
19 cerebellum cancer 10.9 ENO2 SYP
20 subependymal glioma 10.9 ENO2 SYP
21 cerebral neuroblastoma 10.9 ENO2 SYP
22 extraosseous chondrosarcoma 10.9 ENO2 SYP
23 benign ependymoma 10.9 ENO2 SYP
24 malignant teratoma 10.9 ENO2 SYP
25 astroblastoma 10.9 ENO2 SYP
26 endometrial small cell carcinoma 10.9 ENO2 SYP
27 melanotic neuroectodermal tumor 10.9 ENO2 SYP
28 nodular ganglioneuroblastoma 10.9 ENO2 SYP
29 mucinous ovarian cystadenoma 10.9 ENO2 SYP
30 respiratory system benign neoplasm 10.9 ENO2 SYP
31 angiomyoma 10.9 ENO2 SYP
32 gastric squamous cell carcinoma 10.9 ENO2 SYP
33 desmoplastic small round cell tumor 10.9 ENO2 SYP
34 subependymoma 10.9 ENO2 SYP
35 carcinoid tumors, intestinal 10.9 ENO2 SYP
36 bone benign neoplasm 10.9 ENO2 SYP
37 meningeal melanomatosis 10.9 ENO2 SYP
38 cervical clear cell adenocarcinoma 10.9 ENO2 SYP
39 extraskeletal ewing sarcoma 10.8 ENO2 SYP
40 connective tissue benign neoplasm 10.8 ENO2 SYP
41 glomus tumor 10.8 ENO2 SYP
42 intraocular retinoblastoma 10.8 ENO2 SYP
43 sclerosing hemangioma 10.8 ENO2 SYP
44 subependymal giant cell astrocytoma 10.8 ENO2 SYP
45 central neurocytoma 10.8 ENO2 SYP
46 mixed cell type cancer 10.8 ENO2 SYP
47 gangliocytoma 10.8 RBFOX3 SYP
48 sella turcica neoplasm 10.8 RBFOX3 SYP
49 carcinoid syndrome 10.8 ENO2 SYP
50 ovarian mucinous neoplasm 10.8 ENO2 SYP

Graphical network of the top 20 diseases related to Pineal Parenchymal Tumor of Intermediate Differentiation:



Diseases related to Pineal Parenchymal Tumor of Intermediate Differentiation

Symptoms & Phenotypes for Pineal Parenchymal Tumor of Intermediate Differentiation

Drugs & Therapeutics for Pineal Parenchymal Tumor of Intermediate Differentiation

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib

Search NIH Clinical Center for Pineal Parenchymal Tumor of Intermediate Differentiation

Genetic Tests for Pineal Parenchymal Tumor of Intermediate Differentiation

Anatomical Context for Pineal Parenchymal Tumor of Intermediate Differentiation

MalaCards organs/tissues related to Pineal Parenchymal Tumor of Intermediate Differentiation:

41
Pineal, Brain

Publications for Pineal Parenchymal Tumor of Intermediate Differentiation

Articles related to Pineal Parenchymal Tumor of Intermediate Differentiation:

(show all 17)
# Title Authors Year
1
Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation. ( 28800009 )
2017
2
Patterns of care and survival outcomes in patients with pineal parenchymal tumor of intermediate differentiation: An individual patient data analysis. ( 27865543 )
2016
3
Integrated Genomic Characterization of a Pineal Parenchymal Tumor of Intermediate Differentiation. ( 26226092 )
2016
4
Revisiting the metastatic potential of childhood pineal parenchymal tumor of intermediate differentiation: a case report. ( 27226060 )
2016
5
Pineal parenchymal tumor of intermediate differentiation. ( 26549088 )
2015
6
Pineal parenchymal tumor of intermediate differentiation: Treatment outcomes of five cases. ( 24649332 )
2014
7
Late dural relapse of a resected and irradiated pineal parenchymal tumor of intermediate differentiation. ( 24887399 )
2014
8
Spontaneous pineal apoplexy in a pineal parenchymal tumor of intermediate differentiation. ( 23691444 )
2013
9
Importance of initial aggressive treatment for pineal parenchymal tumor of intermediate differentiation: A case report and review of literature. ( 24674270 )
2013
10
Pineal parenchymal tumor of intermediate differentiation with marked elevation of MIB-1 labeling index. ( 22362162 )
2012
11
Pineal parenchymal tumor of intermediate differentiation: imaging spectrum of an unusual tumor in 11 cases. ( 21080159 )
2011
12
Pineal parenchymal tumor of intermediate differentiation with papillary features: a continuum of primary pineal tumors? ( 20521161 )
2011
13
Pineal parenchymal tumor of intermediate differentiation: clinicopathological report and analysis of epidermal growth factor receptor variant III expression. ( 20404701 )
2010
14
Pineal parenchymal tumor of intermediate differentiation showing malignant progression at relapse. ( 19170892 )
2009
15
Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. ( 18266015 )
2008
16
Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. ( 18371183 )
2008
17
Pineal parenchymal tumor of intermediate differentiation with cytologic pleomorphism. ( 16771177 )
2006

Variations for Pineal Parenchymal Tumor of Intermediate Differentiation

Expression for Pineal Parenchymal Tumor of Intermediate Differentiation

Search GEO for disease gene expression data for Pineal Parenchymal Tumor of Intermediate Differentiation.

Pathways for Pineal Parenchymal Tumor of Intermediate Differentiation

Pathways related to Pineal Parenchymal Tumor of Intermediate Differentiation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.76 ENO2 NEFM RBFOX3 RHO SAG SYP
2
Show member pathways
11.32 PPEF1 RHO SAG

GO Terms for Pineal Parenchymal Tumor of Intermediate Differentiation

Cellular components related to Pineal Parenchymal Tumor of Intermediate Differentiation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 ENO2 RBFOX3 TUBB3 UCHL1
2 neuron projection terminus GO:0044306 8.96 SYP UCHL1
3 photoreceptor inner segment GO:0001917 8.8 ENO2 RHO SAG

Biological processes related to Pineal Parenchymal Tumor of Intermediate Differentiation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ischemia GO:0002931 9.16 PANX1 UCHL1
2 rhodopsin mediated signaling pathway GO:0016056 8.96 RHO SAG
3 regulation of rhodopsin mediated signaling pathway GO:0022400 8.8 PPEF1 RHO SAG

Sources for Pineal Parenchymal Tumor of Intermediate Differentiation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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