Pineal Region Choriocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pineal Region Choriocarcinoma

MalaCards integrated aliases for Pineal Region Choriocarcinoma:

Name: Pineal Region Choriocarcinoma ¹² ¹⁵ ⁷⁰

Pineal Choriocarcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5553

NCIt ⁵⁰ C6759

UMLS ⁷⁰ C1335414

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Summaries for Pineal Region Choriocarcinoma

MalaCards based summary : Pineal Region Choriocarcinoma, also known as pineal choriocarcinoma, is related to precocious puberty and choriocarcinoma. An important gene associated with Pineal Region Choriocarcinoma is CD34 (CD34 Molecule), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include pineal and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Pineal Region Choriocarcinoma

Diseases related to Pineal Region Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)

#	Related Disease	Score	Top Affiliating Genes
1	precocious puberty	10.1
2	choriocarcinoma	10.0
3	spinal cord infarction	10.0
4	mutism	9.9
5	akinetic mutism	9.9
6	hypopituitarism	9.9
7	potter's syndrome	9.8	IGF1 CD34
8	skin tag	9.8	IGF1 CD34
9	uterine benign neoplasm	9.8	IGF1 CD34
10	reproductive organ benign neoplasm	9.8	IGF1 CD34
11	central nervous system benign neoplasm	9.8	IGF1 CD34
12	acquired immunodeficiency syndrome	9.8	IGF1 CD34
13	muscular disease	9.8	IGF1 CD34
14	cell type benign neoplasm	9.8	IGF1 CD34
15	brittle bone disorder	9.7	IGF1 CD34
16	peripheral nervous system disease	9.7	IGF1 CD34
17	diamond-blackfan anemia	9.7	IGF1 CD34
18	myeloma, multiple	9.7	IGF1 CD34
19	vascular disease	9.7	IGF1 CD34
20	wilms tumor 1	9.6	IGF1 CD34
21	liver cirrhosis	9.6	IGF1 CD34
22	deficiency anemia	9.5	IGF1 CD34

Graphical network of the top 20 diseases related to Pineal Region Choriocarcinoma:

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Symptoms & Phenotypes for Pineal Region Choriocarcinoma

GenomeRNAi Phenotypes related to Pineal Region Choriocarcinoma according to GeneCards Suite gene sharing:

²⁶ (show all 14)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	9.5	IGF1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.5	IGF1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-139	9.5	CD34 IGF1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.5	IGF1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	9.5	IGF1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-164	9.5	IGF1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.5	IGF1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-193	9.5	IGF1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-203	9.5	CD34
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-208	9.5	IGF1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-24	9.5	CD34
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.5	IGF1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.5	CD34
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.5	IGF1

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Drugs & Therapeutics for Pineal Region Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Pineal Region Choriocarcinoma

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Genetic Tests for Pineal Region Choriocarcinoma

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Anatomical Context for Pineal Region Choriocarcinoma

MalaCards organs/tissues related to Pineal Region Choriocarcinoma:

⁴⁰

Pineal, Spinal Cord

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Publications for Pineal Region Choriocarcinoma

Articles related to Pineal Region Choriocarcinoma:

#	Title	Authors	PMID	Year
1	Tumor cells forming sinusoids connected to vasculature are involved in hemorrhage of pineal choriocarcinoma. ⁶¹	Qi ST...Zhang JL	24847965	2014
2	[Pineal choriocarcinoma: report of a case]. ⁶¹	Cao HY...Xu Z	21215172	2010
3	[Intratumoral hemorrhage in choriocarcinoma during neuroendoscopic third ventriculostomy: case report]. ⁶¹	Murata T...Hongo K	16529025	2006
4	Cervical spinal cord infarction after surgery for a pineal region choriocarcinoma in the sitting position: case report. ⁶¹	Nitta H...Igarashi N	9149270	1997
5	CT of pineal tumors and intracranial germ-cell tumors. ⁶¹	Chang T...Sheng WC	2554702	1989
6	CT of pineal tumors and intracranial germ-cell tumors. ⁶¹	Chang T...Sheng WC	2476011	1989
7	[Pineal choriocarcinoma presenting massive ventricular hemorrhage--a case report]. ⁶¹	Kida Y...Kageyama N	3840234	1985
8	Primary intracranial choriocarcinoma: a report of two cases and a review of the literature. ⁶¹	Chan HS...Becker LE	6541765	1984
9	hCG beta producing pineal choriocarcinoma. ⁶¹	Wass JA...Besser GM	6184187	1982
10	Primary pineal choriocarcinoma with hemorrhage monitored by computerized tomography. Case report. ⁶¹	Fujii T...Saito K	7196441	1981

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Genes for Pineal Region Choriocarcinoma

Genes related to Pineal Region Choriocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CD34	CD34 Molecule	Protein Coding	4.81	DISEASES inferred ¹⁵
2	IGF1	Insulin Like Growth Factor 1	Protein Coding	4.75	DISEASES inferred ¹⁵

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Variations for Pineal Region Choriocarcinoma

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Expression for Pineal Region Choriocarcinoma

Search GEO for disease gene expression data for Pineal Region Choriocarcinoma.

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Pathways for Pineal Region Choriocarcinoma

Pathways related to Pineal Region Choriocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.6	IGF1 CD34

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GO Terms for Pineal Region Choriocarcinoma

Biological processes related to Pineal Region Choriocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.16	IGF1 CD34
2	negative regulation of gene expression	GO:0010629	8.96	IGF1 CD34
3	negative regulation of tumor necrosis factor production	GO:0032720	8.62	IGF1 CD34

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Sources for Pineal Region Choriocarcinoma

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