MCID: PNL011
MIFTS: 20

Pineal Region Germinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pineal Region Germinoma

MalaCards integrated aliases for Pineal Region Germinoma:

Name: Pineal Region Germinoma 12 15
Pineal Germinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7428
NCIt 50 C8712
UMLS 73 C0854912

Summaries for Pineal Region Germinoma

MalaCards based summary : Pineal Region Germinoma, also known as pineal germinoma, is related to malignant pineal area germ cell neoplasm and diabetes insipidus. An important gene associated with Pineal Region Germinoma is AFP (Alpha Fetoprotein). The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and lung.

Related Diseases for Pineal Region Germinoma

Diseases related to Pineal Region Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 malignant pineal area germ cell neoplasm 11.3
2 diabetes insipidus 9.9

Symptoms & Phenotypes for Pineal Region Germinoma

Drugs & Therapeutics for Pineal Region Germinoma

Drugs for Pineal Region Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 184)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
2
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
4
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-75-2 4033
5
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
6 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
8 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1
9 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1
10 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
11
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1 0
12
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
13
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
14
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
15
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
16
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
17
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
18
Ondansetron Approved Phase 3,Phase 2 99614-02-5 4595
19
Mesna Approved, Investigational Phase 3 3375-50-6 598
20
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
21
Promethazine Approved, Investigational Phase 3 60-87-7 4927
22 Serotonin Agents Phase 3,Phase 2
23 Serotonin Antagonists Phase 3,Phase 2
24 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
25 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
26 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
27 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
28 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
29 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
30 Antiemetics Phase 3,Phase 2,Phase 1
31 Antirheumatic Agents Phase 3,Phase 2,Phase 1
32 Autonomic Agents Phase 3,Phase 2,Phase 1
33 Dexamethasone acetate Phase 3,Phase 1 1177-87-3
34 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
35 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
36 Emetics Phase 3
37 BB 1101 Phase 3,Phase 1
38 Antimitotic Agents Phase 3,Phase 2,Phase 1
39 Histamine H2 Antagonists Phase 3
40
Serotonin Investigational, Nutraceutical Phase 3,Phase 2 50-67-9 5202
41
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
42
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
43
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
44
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
45
Oxaliplatin Approved, Investigational Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
46
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177
47
Fluorouracil Approved Phase 2,Phase 1 51-21-8 3385
48
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
49
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
50
Levoleucovorin Approved, Investigational Phase 2,Phase 1 68538-85-2

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Recruiting NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
3 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
4 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
6 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
7 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
8 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
9 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
10 Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
11 Proton Radiotherapy for Stage I, IIA, and IIB Seminoma Unknown status NCT01557790 Phase 2
12 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
13 ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Completed NCT01055067 Phase 2 Tivantinib (ARQ 197)
14 Darbepoetin Alfa in Patients With "Poor Prognosis" Germ Cell Tumor Treated With High-Dose Chemotherapy (HD-VIP) Completed NCT00204633 Phase 2 Darbepoetin alfa
15 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
16 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
17 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
18 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Completed NCT01764802 Phase 2
19 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
20 Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies Completed NCT01079832 Phase 2
21 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
22 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
23 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) Recruiting NCT01270724 Phase 2 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx).
24 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
25 Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
26 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
27 Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting NCT02122185 Phase 2 metformin hydrochloride;placebo;Chemotherapy
28 Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Active, not recruiting NCT01966809 Phase 2 Photofrin photodynamic therapy.
29 Carboplatin AUC-10 for Metastatic Seminoma With IGCCCG Good Prognosis Disease-Therapy Directed by Initial Metabolic Response on PET-CT Active, not recruiting NCT02272816 Phase 2 Carboplatin AUC-10
30 Therapy De-escalation in Seminoma Stage IIA/B Active, not recruiting NCT01593241 Phase 2 Carboplatin
31 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
32 Everolimus and Letrozole in Treating Patients With Recurrent Hormone Receptor Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer Active, not recruiting NCT02283658 Phase 2 Everolimus;Letrozole
33 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Suspended NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
34 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
35 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
36 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload Terminated NCT01159067 Phase 2 deferasirox
37 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
38 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
39 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
40 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
41 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
42 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
43 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
44 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
45 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
46 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1 cefepime hydrochloride
47 Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors Completed NCT01155258 Phase 1 temsirolimus;vinorelbine ditartrate
48 Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Completed NCT01131234 Phase 1 Gamma-Secretase Inhibitor RO4929097;Cediranib Maleate
49 Temsirolimus, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00408655 Phase 1 paclitaxel;carboplatin;temsirolimus
50 Cyclophosphamide or Denileukin Diftitox Followed By Expanding a Patient's Own T Cells in the Laboratory in Treating Patients With HER-2/Neu Overexpressing Metastatic Breast Cancer, Ovarian Cancer, or Non-Small Cell Lung Cancer Previously Treated With HER- Completed NCT00228358 Phase 1 ex vivo-expanded HER2-specific T cells;cyclophosphamide

Search NIH Clinical Center for Pineal Region Germinoma

Genetic Tests for Pineal Region Germinoma

Anatomical Context for Pineal Region Germinoma

MalaCards organs/tissues related to Pineal Region Germinoma:

41
Pineal, Brain, Lung, T Cells, Breast, Spinal Cord, Bone

Publications for Pineal Region Germinoma

Articles related to Pineal Region Germinoma:

# Title Authors Year
1
Late spinal metastases from an isolated pineal region germinoma mimicking a schwannoma. ( 21600775 )
2011
2
Refining the staging evaluation of pineal region germinoma using neuroendoscopy and the presence of preoperative diabetes insipidus. ( 15134627 )
2004
3
[A case of pineal region germinoma treated by interstitial brachytherapy]. ( 8078603 )
1994

Variations for Pineal Region Germinoma

Expression for Pineal Region Germinoma

Search GEO for disease gene expression data for Pineal Region Germinoma.

Pathways for Pineal Region Germinoma

GO Terms for Pineal Region Germinoma

Sources for Pineal Region Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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