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MCID: PNL003
MIFTS: 26

Pineal Region Meningioma

Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Pineal Region Meningioma

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MalaCards integrated aliases for Pineal Region Meningioma:

Name: Pineal Region Meningioma 12 15 71
Pineal Meningioma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8031
NCIt 49 C6756
UMLS 71 C1335418
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Summaries for Pineal Region Meningioma

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MalaCards based summary : Pineal Region Meningioma, also known as pineal meningioma, is related to meningioma, familial and meningioma, radiation-induced, and has symptoms including seizures and headache. An important gene associated with Pineal Region Meningioma is SCRT1 (Scratch Family Transcriptional Repressor 1), and among its related pathways/superpathways are Relaxin signaling pathway and cAMP signaling pathway. Affiliated tissues include pineal, pituitary and thyroid, and related phenotype is homeostasis/metabolism.

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Related Diseases for Pineal Region Meningioma

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Diseases related to Pineal Region Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 29.4 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SMARCB1
2 meningioma, radiation-induced 10.5
3 spinal meningioma 10.5
4 secretory meningioma 10.5
5 lymphoplasmacyte-rich meningioma 10.5
6 skull base meningioma 10.2 SSTR2 SCRT1
7 hydrocephalus 10.2
8 nelson syndrome 10.1 SSTR5 SSTR2
9 pituitary adenoma 10.1 SSTR5 SSTR3 SSTR2
10 pancreatic endocrine carcinoma 10.1 SSTR5 SSTR2
11 oncogenic osteomalacia 10.1 SSTR5 SSTR3 SSTR1
12 optic nerve sheath meningioma 10.0 SMARCB1 SCRT1
13 optic nerve neoplasm 10.0 SMARCB1 SCRT1
14 gastrinoma 10.0 SSTR5 SSTR2 SSTR1
15 thyroid carcinoma, familial medullary 10.0 SSTR5 SSTR2 SSTR1
16 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
17 aphasia 10.0
18 apraxia 10.0
19 agnosia 10.0
20 cranial nerve neoplasm 10.0 SMARCB1 SCRT1
21 rhabdoid meningioma 9.9 SMARCB1 PTPRS
22 growth hormone secreting pituitary adenoma 9.9 SSTR5 SSTR2
23 balanitis 9.9 TGM3 CRP
24 cerebral lymphoma 9.9 SSTR5 SSTR4 SSTR3 SSTR1
25 cerebrovascular benign neoplasm 9.9 SMARCB1 PTPRS
26 nasopharyngitis 9.9 CRP AMELX
27 pineal gland cancer 9.9 SMARCB1 PTPRS
28 acth-secreting pituitary adenoma 9.8 SSTR5 SSTR4 SSTR2 SSTR1
29 acromegaly 9.8 SSTR5 SSTR4 SSTR2 SSTR1
30 polycystic liver disease 9.8 SSTR5 SSTR3 SSTR2 SSTR1
31 papilloma of choroid plexus 9.7 SMARCB1 PTPRS
32 ovarian stromal hyperthecosis 9.7 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
33 posterior pituitary gland neoplasm 9.7 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
34 tsh producing pituitary tumor 9.7 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
35 functionless pituitary adenoma 9.7 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
36 gastrointestinal neuroendocrine tumor 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
37 hormone producing pituitary cancer 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
38 breast neuroendocrine neoplasm 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
39 hyperpituitarism 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
40 thyroid gland medullary carcinoma 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
41 functioning pituitary adenoma 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
42 pancreatic cystadenoma 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
43 thyroid gland follicular carcinoma 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
44 pituitary gland disease 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
45 endocrine organ benign neoplasm 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
46 pituitary adenoma, prolactin-secreting 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
47 thyroid gland cancer 9.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
48 portal vein thrombosis 9.2 CRP CALR

Graphical network of the top 20 diseases related to Pineal Region Meningioma:



Diseases related to Pineal Region Meningioma
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Symptoms & Phenotypes for Pineal Region Meningioma

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UMLS symptoms related to Pineal Region Meningioma:


seizures, headache

MGI Mouse Phenotypes related to Pineal Region Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CALR CRP PTPRS SMARCB1 SSTR1 SSTR2
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Drugs & Therapeutics for Pineal Region Meningioma

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Search Clinical Trials , NIH Clinical Center for Pineal Region Meningioma

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Genetic Tests for Pineal Region Meningioma

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Anatomical Context for Pineal Region Meningioma

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MalaCards organs/tissues related to Pineal Region Meningioma:

40
Pineal, Pituitary, Thyroid, Liver, Breast
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Publications for Pineal Region Meningioma

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Articles related to Pineal Region Meningioma:

(show all 15)
# Title Authors PMID Year
1
Rapid regression of a symptomatic pineal region meningioma after presumed spontaneous central infarction. 61
27290664 2016
2
68Ga-DOTATATE uptake in pineal gland, a rare physiological variant: case series. 61
26173444 2015
3
Use of 3D-computed tomography angiography for planning the surgical removal of pineal region meningiomas using Poppen's approach: a report of ten cases and a literature review. 61
21676231 2011
4
[Suboccipital transtentorial approach to pineal region meningiomas by 3D-CTA assistance: surgical considerations]. 61
21609570 2011
5
High precision focused irradiation in the form of fractionated stereotactic conformal radiotherapy (SCRT) for benign meningiomas predominantly in the skull base location. 61
12069116 2002
6
A case of pineal region meningioma without dural attachment, presented with bilateral hearing impairment. 61
11862524 2002
7
Peduncular hallucinosis due to a pineal meningioma. Case report. 61
11565874 2001
8
Pineal region meningioma without dural attachment. 61
8799544 1996
9
Surgical removal of pineal region meningioma--three case reports. 61
7566392 1995
10
Hearing impairment resulting from a pineal region meningioma. 61
8474658 1993
11
Pineal meningioma: MRI. 61
8232885 1993
12
Combined supratentorial and infratentorial approach to large pineal-region meningioma. 61
1536024 1992
13
Meningioma in the pineal region: preoperative diagnosis with CT, MRI, and angiography. 61
1852901 1991
14
[Meningioma of pineal region]. 61
2215869 1990
15
Pineal region meningioma: report of two cases and literature review. 61
6856061 1983
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Variations for Pineal Region Meningioma

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Expression for Pineal Region Meningioma

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Search GEO for disease gene expression data for Pineal Region Meningioma.
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Pathways for Pineal Region Meningioma

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Pathways related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Relaxin signaling pathway 36
Show member pathways
 11.52 SSTR5 SSTR3 SSTR2 SSTR1
2
cAMP signaling pathway 36
11.47 SSTR5 SSTR2 SSTR1
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GO Terms for Pineal Region Meningioma

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Cellular components related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.1 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 PTPRS
2 non-motile cilium GO:0097730 8.96 SSTR3 SEPTIN2

Biological processes related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.99 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 AMELX
2 G protein-coupled receptor signaling pathway GO:0007186 9.89 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3 spermatogenesis GO:0007283 9.88 SSTR3 SSTR2 SSTR1 SEPTIN2 CALR
4 negative regulation of cell proliferation GO:0008285 9.88 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SMARCB1
5 forebrain development GO:0030900 9.67 SSTR4 SSTR3 SSTR2 SSTR1
6 neuropeptide signaling pathway GO:0007218 9.65 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
7 response to starvation GO:0042594 9.63 SSTR3 SSTR2 SSTR1
8 cerebellum development GO:0021549 9.62 SSTR3 SSTR2 SSTR1 PTPRS
9 cellular response to estradiol stimulus GO:0071392 9.61 SSTR3 SSTR2 SSTR1
10 cellular response to glucocorticoid stimulus GO:0071385 9.46 SSTR5 SSTR4 SSTR3 SSTR2
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
12 somatostatin signaling pathway GO:0038170 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Molecular functions related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.72 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2 neuropeptide binding GO:0042923 9.55 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3 peptide binding GO:0042277 9.43 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 CALR
4 complement component C1q binding GO:0001849 9.26 CRP CALR
5 somatostatin receptor activity GO:0004994 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
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Sources for Pineal Region Meningioma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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