MCID: PNL003
MIFTS: 25

Pineal Region Meningioma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pineal Region Meningioma

MalaCards integrated aliases for Pineal Region Meningioma:

Name: Pineal Region Meningioma 12 15 74
Pineal Meningioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8031
NCIt 51 C6756
UMLS 74 C1335418

Summaries for Pineal Region Meningioma

MalaCards based summary : Pineal Region Meningioma, also known as pineal meningioma, is related to hormone producing pituitary cancer and pancreatic endocrine carcinoma, and has symptoms including seizures and headache. An important gene associated with Pineal Region Meningioma is SSTR3 (Somatostatin Receptor 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include pineal, and related phenotype is Increased gamma-H2AX phosphorylation.

Related Diseases for Pineal Region Meningioma

Diseases related to Pineal Region Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hormone producing pituitary cancer 9.9 SSTR2 SSTR5
2 pancreatic endocrine carcinoma 9.8 SSTR2 SSTR5
3 oncogenic osteomalacia 9.8 SSTR1 SSTR3 SSTR5
4 acromegaly 9.7 SSTR1 SSTR2 SSTR5
5 thyroid carcinoma, familial medullary 9.7 SSTR1 SSTR2 SSTR5
6 meningioma, familial 9.7 KANTR SSTR2
7 pituitary adenoma, prolactin-secreting 9.5 SSTR1 SSTR2 SSTR3 SSTR5

Graphical network of the top 20 diseases related to Pineal Region Meningioma:



Diseases related to Pineal Region Meningioma

Symptoms & Phenotypes for Pineal Region Meningioma

UMLS symptoms related to Pineal Region Meningioma:


seizures, headache

GenomeRNAi Phenotypes related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.02 SCRT1 SSTR1 SSTR2 SSTR3 SSTR4

Drugs & Therapeutics for Pineal Region Meningioma

Search Clinical Trials , NIH Clinical Center for Pineal Region Meningioma

Genetic Tests for Pineal Region Meningioma

Anatomical Context for Pineal Region Meningioma

MalaCards organs/tissues related to Pineal Region Meningioma:

42
Pineal

Publications for Pineal Region Meningioma

Articles related to Pineal Region Meningioma:

# Title Authors Year
1
Rapid regression of a symptomatic pineal region meningioma after presumed spontaneous central infarction. ( 27290664 )
2016
2
A case of pineal region meningioma without dural attachment, presented with bilateral hearing impairment. ( 11862524 )
2002
3
Peduncular hallucinosis due to a pineal meningioma. Case report. ( 11565874 )
2001
4
Pineal region meningioma without dural attachment. ( 8799544 )
1996
5
Surgical removal of pineal region meningioma--three case reports. ( 7566392 )
1995
6
Hearing impairment resulting from a pineal region meningioma. ( 8474658 )
1993
7
Pineal meningioma: MRI. ( 8232885 )
1993
8
Combined supratentorial and infratentorial approach to large pineal-region meningioma. ( 1536024 )
1992
9
Pineal region meningioma: report of two cases and literature review. ( 6856061 )
1983

Variations for Pineal Region Meningioma

Expression for Pineal Region Meningioma

Search GEO for disease gene expression data for Pineal Region Meningioma.

Pathways for Pineal Region Meningioma

GO Terms for Pineal Region Meningioma

Cellular components related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.43 KANTR SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2 integral component of plasma membrane GO:0005887 9.02 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Biological processes related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.89 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2 G protein-coupled receptor signaling pathway GO:0007186 9.88 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
3 negative regulation of cell proliferation GO:0008285 9.77 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
4 spermatogenesis GO:0007283 9.69 SSTR1 SSTR2 SSTR3
5 cerebellum development GO:0021549 9.63 SSTR1 SSTR2 SSTR3
6 forebrain development GO:0030900 9.62 SSTR1 SSTR2 SSTR3 SSTR4
7 cellular response to estradiol stimulus GO:0071392 9.61 SSTR1 SSTR2 SSTR3
8 response to starvation GO:0042594 9.58 SSTR1 SSTR2 SSTR3
9 cellular response to glucocorticoid stimulus GO:0071385 9.56 SSTR2 SSTR3 SSTR4 SSTR5
10 neuropeptide signaling pathway GO:0007218 9.55 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.35 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
12 somatostatin signaling pathway GO:0038170 9.02 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Molecular functions related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.55 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2 neuropeptide binding GO:0042923 9.35 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
3 somatostatin receptor activity GO:0004994 9.02 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Sources for Pineal Region Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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