Pineal Region Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pineal Region Meningioma

MalaCards integrated aliases for Pineal Region Meningioma:

Name: Pineal Region Meningioma ¹² ¹⁵ ⁷⁴

Pineal Meningioma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8031

NCIt ⁵¹ C6756

UMLS ⁷⁴ C1335418

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Summaries for Pineal Region Meningioma

MalaCards based summary : Pineal Region Meningioma, also known as pineal meningioma, is related to hormone producing pituitary cancer and pancreatic endocrine carcinoma, and has symptoms including seizures and headache. An important gene associated with Pineal Region Meningioma is SSTR3 (Somatostatin Receptor 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include pineal, and related phenotype is Increased gamma-H2AX phosphorylation.

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Related Diseases for Pineal Region Meningioma

Diseases related to Pineal Region Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	hormone producing pituitary cancer	9.9	SSTR2 SSTR5
2	pancreatic endocrine carcinoma	9.8	SSTR2 SSTR5
3	oncogenic osteomalacia	9.8	SSTR1 SSTR3 SSTR5
4	acromegaly	9.7	SSTR1 SSTR2 SSTR5
5	thyroid carcinoma, familial medullary	9.7	SSTR1 SSTR2 SSTR5
6	meningioma, familial	9.7	KANTR SSTR2
7	pituitary adenoma, prolactin-secreting	9.5	SSTR1 SSTR2 SSTR3 SSTR5

Graphical network of the top 20 diseases related to Pineal Region Meningioma:

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Symptoms & Phenotypes for Pineal Region Meningioma

UMLS symptoms related to Pineal Region Meningioma:

seizures, headache

GenomeRNAi Phenotypes related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased gamma-H2AX phosphorylation	GR00053-A	9.02	SCRT1 SSTR1 SSTR2 SSTR3 SSTR4

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Drugs & Therapeutics for Pineal Region Meningioma

Search Clinical Trials , NIH Clinical Center for Pineal Region Meningioma

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Genetic Tests for Pineal Region Meningioma

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Anatomical Context for Pineal Region Meningioma

MalaCards organs/tissues related to Pineal Region Meningioma:

⁴²

Pineal

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Publications for Pineal Region Meningioma

Articles related to Pineal Region Meningioma:

#	Title	Authors	Year
1	Rapid regression of a symptomatic pineal region meningioma after presumed spontaneous central infarction. ( 27290664 )	Galloway L....Hayhurst C.	2016
2	A case of pineal region meningioma without dural attachment, presented with bilateral hearing impairment. ( 11862524 )	Haque M....Hara M.	2002
3	Peduncular hallucinosis due to a pineal meningioma. Case report. ( 11565874 )	Miyazawa T...Shima K	2001
4	Pineal region meningioma without dural attachment. ( 8799544 )	Madawi A.A....Stevens J.M.	1996
5	Surgical removal of pineal region meningioma--three case reports. ( 7566392 )	Matsuda Y....Inagawa T.	1995
6	Hearing impairment resulting from a pineal region meningioma. ( 8474658 )	DeMonte F....Al-Mefty O.	1993
7	Pineal meningioma: MRI. ( 8232885 )	Iplik?io?lu AC...Buharali Z	1993
8	Combined supratentorial and infratentorial approach to large pineal-region meningioma. ( 1536024 )	Sekhar L.N....Goel A.	1992
9	Pineal region meningioma: report of two cases and literature review. ( 6856061 )	Piatt J.H....Campbell G.A.	1983

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Genes for Pineal Region Meningioma

Genes related to Pineal Region Meningioma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SSTR3	Somatostatin Receptor 3	Protein Coding	15.05	DISEASES inferred ¹⁵
2	SSTR1	Somatostatin Receptor 1	Protein Coding	14.98	DISEASES inferred ¹⁵
3	SSTR5	Somatostatin Receptor 5	Protein Coding	14.94	DISEASES inferred ¹⁵
4	SSTR2	Somatostatin Receptor 2	Protein Coding	14.8	DISEASES inferred ¹⁵
5	SCRT1	Scratch Family Transcriptional Repressor 1	Protein Coding	5.84	DISEASES inferred ¹⁵
6	SSTR4	Somatostatin Receptor 4	Protein Coding	5.08	DISEASES inferred ¹⁵
7	KANTR	KDM5C Adjacent Transcript	RNA Gene	3.94	DISEASES inferred ¹⁵

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Variations for Pineal Region Meningioma

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Expression for Pineal Region Meningioma

Search GEO for disease gene expression data for Pineal Region Meningioma.

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Pathways for Pineal Region Meningioma

Pathways related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶⁷ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁷ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁷ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁷ G alpha (i) signalling events ⁶⁷ GPCR ligand binding ⁶⁷ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁸ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁷ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁷ Vasopressin-like receptors ⁶⁷	12.64	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.37	SSTR1 SSTR2
3	cAMP signaling pathway ³⁸	11.13	SSTR1 SSTR2 SSTR5

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GO Terms for Pineal Region Meningioma

Cellular components related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of membrane	GO:0016021	9.43	KANTR SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2	integral component of plasma membrane	GO:0005887	9.02	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Biological processes related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	9.89	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2	G protein-coupled receptor signaling pathway	GO:0007186	9.88	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
3	negative regulation of cell proliferation	GO:0008285	9.77	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
4	spermatogenesis	GO:0007283	9.69	SSTR1 SSTR2 SSTR3
5	cerebellum development	GO:0021549	9.63	SSTR1 SSTR2 SSTR3
6	forebrain development	GO:0030900	9.62	SSTR1 SSTR2 SSTR3 SSTR4
7	cellular response to estradiol stimulus	GO:0071392	9.61	SSTR1 SSTR2 SSTR3
8	response to starvation	GO:0042594	9.58	SSTR1 SSTR2 SSTR3
9	cellular response to glucocorticoid stimulus	GO:0071385	9.56	SSTR2 SSTR3 SSTR4 SSTR5
10	neuropeptide signaling pathway	GO:0007218	9.55	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
11	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	9.35	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
12	somatostatin signaling pathway	GO:0038170	9.02	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Molecular functions related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor activity	GO:0004930	9.55	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2	neuropeptide binding	GO:0042923	9.35	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
3	somatostatin receptor activity	GO:0004994	9.02	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

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Sources for Pineal Region Meningioma

¹ BioSystems

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²¹ GeneAnalytics

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²⁵ GeneReviews

²⁶ Genetics Home Reference

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²⁸ GEO DataSets

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³¹ HGMD

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³⁴ ICD10

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³⁷ IUPHAR

³⁸ KEGG

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⁴⁰ LncRNADisease

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⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia