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MCID: PNL003
MIFTS: 25

Pineal Region Meningioma

Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Pineal Region Meningioma

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MalaCards integrated aliases for Pineal Region Meningioma:

Name: Pineal Region Meningioma 12 15 72
Pineal Meningioma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8031
NCIt 50 C6756
UMLS 72 C1335418
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Summaries for Pineal Region Meningioma

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MalaCards based summary : Pineal Region Meningioma, also known as pineal meningioma, is related to meningioma, radiation-induced and meningioma, familial, and has symptoms including seizures and headache. An important gene associated with Pineal Region Meningioma is AMELX (Amelogenin X-Linked), and among its related pathways/superpathways are Peptide ligand-binding receptors and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include pineal, and related phenotype is Increased gamma-H2AX phosphorylation.

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Related Diseases for Pineal Region Meningioma

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Diseases related to Pineal Region Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 meningioma, radiation-induced 10.5
2 meningioma, familial 10.5
3 spinal meningioma 10.5
4 secretory meningioma 10.5
5 lymphoplasmacyte-rich meningioma 10.5
6 hydrocephalus 10.2
7 congenital hydrocephalus 10.2
8 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
9 aphasia 10.0
10 apraxia 10.0
11 agnosia 10.0
12 pancreatic endocrine carcinoma 9.7 SSTR5 SSTR2
13 oncogenic osteomalacia 9.5 SSTR5 SSTR3 SSTR1
14 hormone producing pituitary cancer 9.4 SSTR5 SSTR2
15 acromegaly 9.2 SSTR5 SSTR2 SSTR1
16 thyroid carcinoma, familial medullary 9.1 SSTR5 SSTR2 SSTR1
17 pituitary adenoma, prolactin-secreting 9.0 SSTR5 SSTR3 SSTR2 SSTR1

Graphical network of the top 20 diseases related to Pineal Region Meningioma:



Diseases related to Pineal Region Meningioma
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Symptoms & Phenotypes for Pineal Region Meningioma

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UMLS symptoms related to Pineal Region Meningioma:


seizures, headache

GenomeRNAi Phenotypes related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.02 SCRT1 SSTR1 SSTR2 SSTR3 SSTR4
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Drugs & Therapeutics for Pineal Region Meningioma

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Search Clinical Trials , NIH Clinical Center for Pineal Region Meningioma

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Genetic Tests for Pineal Region Meningioma

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Anatomical Context for Pineal Region Meningioma

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MalaCards organs/tissues related to Pineal Region Meningioma:

41
Pineal
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Publications for Pineal Region Meningioma

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Articles related to Pineal Region Meningioma:

(show all 15)
# Title Authors PMID Year
1
Rapid regression of a symptomatic pineal region meningioma after presumed spontaneous central infarction. 38
27290664 2016
2
68Ga-DOTATATE uptake in pineal gland, a rare physiological variant: case series. 38
26173444 2015
3
Use of 3D-computed tomography angiography for planning the surgical removal of pineal region meningiomas using Poppen's approach: a report of ten cases and a literature review. 38
21676231 2011
4
[Suboccipital transtentorial approach to pineal region meningiomas by 3D-CTA assistance: surgical considerations]. 38
21609570 2011
5
High precision focused irradiation in the form of fractionated stereotactic conformal radiotherapy (SCRT) for benign meningiomas predominantly in the skull base location. 38
12069116 2002
6
A case of pineal region meningioma without dural attachment, presented with bilateral hearing impairment. 38
11862524 2002
7
Peduncular hallucinosis due to a pineal meningioma. Case report. 38
11565874 2001
8
Pineal region meningioma without dural attachment. 38
8799544 1996
9
Surgical removal of pineal region meningioma--three case reports. 38
7566392 1995
10
Hearing impairment resulting from a pineal region meningioma. 38
8474658 1993
11
Pineal meningioma: MRI. 38
8232885 1993
12
Combined supratentorial and infratentorial approach to large pineal-region meningioma. 38
1536024 1992
13
Meningioma in the pineal region: preoperative diagnosis with CT, MRI, and angiography. 38
1852901 1991
14
[Meningioma of pineal region]. 38
2215869 1990
15
Pineal region meningioma: report of two cases and literature review. 38
6856061 1983
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Variations for Pineal Region Meningioma

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Expression for Pineal Region Meningioma

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Search GEO for disease gene expression data for Pineal Region Meningioma.
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Pathways for Pineal Region Meningioma

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Pathways related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 66
Show member pathways
 12.64 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.37 SSTR2 SSTR1
3
cAMP signaling pathway 37
11.13 SSTR5 SSTR2 SSTR1
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GO Terms for Pineal Region Meningioma

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Cellular components related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Biological processes related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.95 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 AMELX
2 G protein-coupled receptor signaling pathway GO:0007186 9.89 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3 negative regulation of cell proliferation GO:0008285 9.77 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
4 spermatogenesis GO:0007283 9.69 SSTR3 SSTR2 SSTR1
5 cerebellum development GO:0021549 9.63 SSTR3 SSTR2 SSTR1
6 forebrain development GO:0030900 9.62 SSTR4 SSTR3 SSTR2 SSTR1
7 response to starvation GO:0042594 9.61 SSTR3 SSTR2 SSTR1
8 cellular response to estradiol stimulus GO:0071392 9.58 SSTR3 SSTR2 SSTR1
9 cellular response to glucocorticoid stimulus GO:0071385 9.56 SSTR5 SSTR4 SSTR3 SSTR2
10 neuropeptide signaling pathway GO:0007218 9.55 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
12 somatostatin signaling pathway GO:0038170 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Molecular functions related to Pineal Region Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.55 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2 neuropeptide binding GO:0042923 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3 somatostatin receptor activity GO:0004994 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
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Sources for Pineal Region Meningioma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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