MCID: PNL015
MIFTS: 24

Pineal Region Teratoma

Categories: Cancer diseases

Aliases & Classifications for Pineal Region Teratoma

MalaCards integrated aliases for Pineal Region Teratoma:

Name: Pineal Region Teratoma 12 15 70
Teratoma of Pineal Area 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6856
NCIt 50 C6753
UMLS 70 C1335419

Summaries for Pineal Region Teratoma

MalaCards based summary : Pineal Region Teratoma, also known as teratoma of pineal area, is related to teratoma and scrotum neoplasm. An important gene associated with Pineal Region Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Myogenesis and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include pineal, lung and prostate, and related phenotype is neoplasm.

Related Diseases for Pineal Region Teratoma

Diseases related to Pineal Region Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
# Related Disease Score Top Affiliating Genes
1 teratoma 28.8 SYP SMARCB1 KIT ENO2 AFP
2 scrotum neoplasm 10.2 MYOG AFP
3 pineal region meningioma 10.2 SMARCB1 AFP
4 malignant glandular tumor of peripheral nerve sheath 10.2 SMARCB1 MYOG
5 juvenile type testicular granulosa cell tumor 10.2 SMARCB1 AFP
6 germinoma 10.2 KIT AFP
7 testicular granulosa cell tumor 10.2 SMARCB1 AFP
8 mediastinum seminoma 10.2 KIT AFP
9 mixed germ cell tumor 10.2 KIT AFP
10 extragonadal seminoma 10.2 KIT AFP
11 embryonal rhabdomyosarcoma 10.2 MYOG MYOD1
12 gallbladder leiomyosarcoma 10.2 KIT AFP
13 epididymal neoplasm 10.2 MYOD1 AFP
14 liver leiomyoma 10.2 KIT AFP
15 intratubular embryonal carcinoma 10.2 KIT AFP
16 mixed germ cell cancer 10.2 KIT AFP
17 ovarian mixed germ cell neoplasm 10.2 KIT AFP
18 conventional leiomyosarcoma 10.2 MYOG MYOD1
19 skeletal muscle neoplasm 10.2 MYOG MYOD1
20 epithelioid malignant peripheral nerve sheath tumor 10.2 SMARCB1 MYOG
21 undifferentiated embryonal sarcoma of the liver 10.2 MYOG MYOD1
22 sarcomatous intrahepatic cholangiocarcinoma 10.2 KIT AFP
23 inflammatory leiomyosarcoma 10.2 MYOG MYOD1
24 gallbladder sarcoma 10.2 MYOG MYOD1
25 prostate rhabdomyosarcoma 10.2 MYOG MYOD1
26 dysgerminoma of ovary 10.2 KIT AFP
27 ovarian gonadoblastoma 10.2 KIT AFP
28 adult fibrosarcoma 10.1 MYOG MYOD1
29 brain germinoma 10.1 KIT AFP
30 malignant triton tumor 10.1 MYOG MYOD1
31 heart sarcoma 10.1 MYOG KIT
32 malignant mesenchymoma 10.1 MYOG MYOD1
33 vagina sarcoma 10.1 MYOG KIT
34 cervical adenosarcoma 10.1 MYOG MYOD1
35 seminal vesicle adenocarcinoma 10.1 KIT AFP
36 paratesticular lipoma 10.1 ENO2 AFP
37 lipoma of spermatic cord 10.1 ENO2 AFP
38 uterine corpus sarcoma 10.1 MYOG KIT
39 mature teratoma of the ovary 10.1 ENO2 AFP
40 heart cancer 10.1 MYOG KIT
41 spindle cell rhabdomyosarcoma 10.1 MYOG MYOD1
42 gas gangrene 10.1 MYOG MYOD1
43 spermatocytoma 10.1 KIT AFP
44 large cell carcinoma with rhabdoid phenotype 10.1 SMARCB1 ENO2
45 ectomesenchymoma 10.1 MYOG ENO2
46 pseudosarcomatous fibromatosis 10.1 MYOG KIT
47 bladder leiomyoma 10.1 MYOD1 KIT
48 mesenchymal cell neoplasm 10.1 MYOG KIT
49 angiomyoma 10.0 KIT ENO2
50 retroperitoneal hemangiopericytoma 10.0 KIT ENO2

Graphical network of the top 20 diseases related to Pineal Region Teratoma:



Diseases related to Pineal Region Teratoma

Symptoms & Phenotypes for Pineal Region Teratoma

MGI Mouse Phenotypes related to Pineal Region Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AFP KIT MYOD1 SMARCB1

Drugs & Therapeutics for Pineal Region Teratoma

Search Clinical Trials , NIH Clinical Center for Pineal Region Teratoma

Genetic Tests for Pineal Region Teratoma

Anatomical Context for Pineal Region Teratoma

MalaCards organs/tissues related to Pineal Region Teratoma:

40
Pineal, Lung, Prostate, Liver, Breast, Ovary, Thymus

Publications for Pineal Region Teratoma

Articles related to Pineal Region Teratoma:

# Title Authors PMID Year
1
Management of mature pineal region teratomas in pediatric age group. 61
31144023 2020
2
Midline Posterior Fossa Mature Teratoma in a Child. 61
30090150 2018
3
Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. 61
16503489 2006

Variations for Pineal Region Teratoma

Expression for Pineal Region Teratoma

Search GEO for disease gene expression data for Pineal Region Teratoma.

Pathways for Pineal Region Teratoma

Pathways related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.92 MYOG MYOD1
2 10.78 MYOG MYOD1 KIT
3 10.7 SMARCB1 MYOD1

GO Terms for Pineal Region Teratoma

Biological processes related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 9.49 MYOG MYOD1
2 skeletal muscle cell differentiation GO:0035914 9.48 MYOG MYOD1
3 cellular response to estradiol stimulus GO:0071392 9.46 MYOG MYOD1
4 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOG MYOD1
5 skeletal muscle fiber development GO:0048741 9.4 MYOG MYOD1
6 skeletal muscle tissue regeneration GO:0043403 9.37 MYOG MYOD1
7 positive regulation of myoblast differentiation GO:0045663 9.32 MYOG MYOD1
8 myoblast differentiation GO:0045445 9.26 MYOG MYOD1
9 myotube differentiation GO:0014902 9.16 MYOG MYOD1
10 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOG MYOD1
11 muscle cell fate commitment GO:0042693 8.62 MYOG MYOD1

Molecular functions related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 E-box binding GO:0070888 8.96 MYOG MYOD1
2 SH2 domain binding GO:0042169 8.62 SYP KIT

Sources for Pineal Region Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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