MCID: PNL015
MIFTS: 22

Pineal Region Teratoma

Categories: Cancer diseases
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Aliases & Classifications for Pineal Region Teratoma

MalaCards integrated aliases for Pineal Region Teratoma:

Name: Pineal Region Teratoma 11 14 71
Teratoma of Pineal Area 11

Classifications:



External Ids:

Disease Ontology 11 DOID:6856
NCIt 49 C6753
UMLS 71 C1335419

Summaries for Pineal Region Teratoma

MalaCards based summary: Pineal Region Teratoma, also known as teratoma of pineal area, is related to teratoma and mature teratoma. An important gene associated with Pineal Region Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Mesenchymal Stem Cells and Lineage-specific Markers. Affiliated tissues include pineal, and related phenotype is neoplasm.

Related Diseases for Pineal Region Teratoma

Diseases related to Pineal Region Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 teratoma 29.5 SYP KIT ENO2 AFP
2 mature teratoma 29.2 SYP KIT ENO2 AFP
3 malignant teratoma 28.8 SYP SMARCB1 KIT ENO2 AFP
4 scrotum neoplasm 10.2 MYOG AFP
5 testicular granulosa cell tumor 10.2 SMARCB1 AFP
6 mediastinum seminoma 10.2 KIT AFP
7 germinoma 10.2 KIT AFP
8 testicular gonadoblastoma 10.2 KIT AFP
9 gonadoblastoma 10.2 KIT AFP
10 malignant gastric teratoma 10.1 KIT AFP
11 gastric teratoma 10.1 KIT AFP
12 extragonadal seminoma 10.1 KIT AFP
13 epididymal neoplasm 10.1 MYOD1 AFP
14 adult type testicular granulosa cell tumor 10.1 KIT AFP
15 intratubular embryonal carcinoma 10.1 KIT AFP
16 ovarian mixed germ cell neoplasm 10.1 KIT AFP
17 hepatic angiomyolipoma 10.1 KIT AFP
18 angiomyolipoma 10.1 KIT AFP
19 oral rhabdomyosarcoma 10.1 MYOG MYOD1
20 sarcomatoid squamous cell skin carcinoma 10.1 SMARCB1 MYOG
21 liver leiomyoma 10.1 KIT AFP
22 vagina leiomyosarcoma 10.1 MYOG KIT
23 juvenile type testicular granulosa cell tumor 10.1 SMARCB1 AFP
24 skeletal muscle neoplasm 10.1 MYOG MYOD1
25 dysgerminoma of ovary 10.1 KIT AFP
26 inflammatory leiomyosarcoma 10.1 MYOG MYOD1
27 prostate rhabdomyosarcoma 10.1 MYOG MYOD1
28 sarcomatosis 10.1 MYOG KIT
29 prostate sarcoma 10.1 MYOG MYOD1
30 ovarian gonadoblastoma 10.1 KIT AFP
31 epithelioid leiomyosarcoma 10.1 MYOG KIT
32 childhood ovarian germ cell tumor 10.1 ENO2 AFP
33 extraosseous osteosarcoma 10.1 MYOG KIT
34 breast sarcoma 10.1 MYOG KIT
35 brain germinoma 10.1 KIT AFP
36 heart sarcoma 10.1 MYOG KIT
37 cervical adenosarcoma 10.1 MYOG MYOD1
38 spindle cell rhabdomyosarcoma 10.1 MYOG MYOD1
39 kidney cortex disease 10.1 SMARCB1 MYOG
40 retroperitoneal leiomyosarcoma 10.1 SMARCB1 KIT
41 liver leiomyosarcoma 10.1 KIT AFP
42 vagina sarcoma 10.1 MYOG KIT
43 cellular schwannoma 10.1 SMARCB1 KIT
44 retroperitoneal sarcoma 10.1 MYOG KIT
45 orbit rhabdomyosarcoma 10.1 MYOG MYOD1
46 heart cancer 10.1 MYOG KIT
47 adult malignant schwannoma 10.1 MYOG KIT
48 progressive relapsing multiple sclerosis 10.1 MYOG MYOD1
49 pleomorphic liposarcoma 10.0 MYOG KIT
50 gas gangrene 10.0 MYOG MYOD1

Graphical network of the top 20 diseases related to Pineal Region Teratoma:



Diseases related to Pineal Region Teratoma

Symptoms & Phenotypes for Pineal Region Teratoma

MGI Mouse Phenotypes related to Pineal Region Teratoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AFP KIT MYOD1 SMARCB1

Drugs & Therapeutics for Pineal Region Teratoma

Search Clinical Trials, NIH Clinical Center for Pineal Region Teratoma

Genetic Tests for Pineal Region Teratoma

Anatomical Context for Pineal Region Teratoma

Organs/tissues related to Pineal Region Teratoma:

MalaCards : Pineal

Publications for Pineal Region Teratoma

Articles related to Pineal Region Teratoma:

# Title Authors PMID Year
1
Pineal region teratoma with metastases in uncommon locations: a case report. 62
35739572 2022
2
Resection of a recurrent pineal region teratoma via a posterior interhemispheric transcallosal approach. 62
36284908 2021
3
Management of mature pineal region teratomas in pediatric age group. 62
31144023 2020
4
Midline Posterior Fossa Mature Teratoma in a Child. 62
30090150 2018
5
Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. 62
16503489 2006

Variations for Pineal Region Teratoma

Expression for Pineal Region Teratoma

Search GEO for disease gene expression data for Pineal Region Teratoma.

Pathways for Pineal Region Teratoma

Pathways related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.9 SMARCB1 MYOD1
2 10.78 MYOG MYOD1 KIT
3 10.43 MYOG MYOD1

GO Terms for Pineal Region Teratoma

Biological processes related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle fiber development GO:0048741 9.62 MYOG MYOD1
2 positive regulation of skeletal muscle fiber development GO:0048743 9.46 MYOG MYOD1
3 myotube differentiation GO:0014902 9.26 MYOG MYOD1
4 muscle cell fate commitment GO:0042693 9.26 MYOG MYOD1
5 positive regulation of myoblast differentiation GO:0045663 9.1 SMARCB1 MYOG MYOD1

Molecular functions related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity GO:0001216 8.62 MYOG MYOD1

Sources for Pineal Region Teratoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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