Pineal Region Teratoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pineal Region Teratoma

MalaCards integrated aliases for Pineal Region Teratoma:

Name: Pineal Region Teratoma ¹² ¹⁵ ⁷⁰

Teratoma of Pineal Area ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6856

NCIt ⁵⁰ C6753

UMLS ⁷⁰ C1335419

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Summaries for Pineal Region Teratoma

MalaCards based summary : Pineal Region Teratoma, also known as teratoma of pineal area, is related to teratoma and scrotum neoplasm. An important gene associated with Pineal Region Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Myogenesis and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include pineal, lung and prostate, and related phenotype is neoplasm.

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Related Diseases for Pineal Region Teratoma

Diseases related to Pineal Region Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)

#	Related Disease	Score	Top Affiliating Genes
1	teratoma	28.8	SYP SMARCB1 KIT ENO2 AFP
2	scrotum neoplasm	10.2	MYOG AFP
3	pineal region meningioma	10.2	SMARCB1 AFP
4	malignant glandular tumor of peripheral nerve sheath	10.2	SMARCB1 MYOG
5	juvenile type testicular granulosa cell tumor	10.2	SMARCB1 AFP
6	germinoma	10.2	KIT AFP
7	testicular granulosa cell tumor	10.2	SMARCB1 AFP
8	mediastinum seminoma	10.2	KIT AFP
9	mixed germ cell tumor	10.2	KIT AFP
10	extragonadal seminoma	10.2	KIT AFP
11	embryonal rhabdomyosarcoma	10.2	MYOG MYOD1
12	gallbladder leiomyosarcoma	10.2	KIT AFP
13	epididymal neoplasm	10.2	MYOD1 AFP
14	liver leiomyoma	10.2	KIT AFP
15	intratubular embryonal carcinoma	10.2	KIT AFP
16	mixed germ cell cancer	10.2	KIT AFP
17	ovarian mixed germ cell neoplasm	10.2	KIT AFP
18	conventional leiomyosarcoma	10.2	MYOG MYOD1
19	skeletal muscle neoplasm	10.2	MYOG MYOD1
20	epithelioid malignant peripheral nerve sheath tumor	10.2	SMARCB1 MYOG
21	undifferentiated embryonal sarcoma of the liver	10.2	MYOG MYOD1
22	sarcomatous intrahepatic cholangiocarcinoma	10.2	KIT AFP
23	inflammatory leiomyosarcoma	10.2	MYOG MYOD1
24	gallbladder sarcoma	10.2	MYOG MYOD1
25	prostate rhabdomyosarcoma	10.2	MYOG MYOD1
26	dysgerminoma of ovary	10.2	KIT AFP
27	ovarian gonadoblastoma	10.2	KIT AFP
28	adult fibrosarcoma	10.1	MYOG MYOD1
29	brain germinoma	10.1	KIT AFP
30	malignant triton tumor	10.1	MYOG MYOD1
31	heart sarcoma	10.1	MYOG KIT
32	malignant mesenchymoma	10.1	MYOG MYOD1
33	vagina sarcoma	10.1	MYOG KIT
34	cervical adenosarcoma	10.1	MYOG MYOD1
35	seminal vesicle adenocarcinoma	10.1	KIT AFP
36	paratesticular lipoma	10.1	ENO2 AFP
37	lipoma of spermatic cord	10.1	ENO2 AFP
38	uterine corpus sarcoma	10.1	MYOG KIT
39	mature teratoma of the ovary	10.1	ENO2 AFP
40	heart cancer	10.1	MYOG KIT
41	spindle cell rhabdomyosarcoma	10.1	MYOG MYOD1
42	gas gangrene	10.1	MYOG MYOD1
43	spermatocytoma	10.1	KIT AFP
44	large cell carcinoma with rhabdoid phenotype	10.1	SMARCB1 ENO2
45	ectomesenchymoma	10.1	MYOG ENO2
46	pseudosarcomatous fibromatosis	10.1	MYOG KIT
47	bladder leiomyoma	10.1	MYOD1 KIT
48	mesenchymal cell neoplasm	10.1	MYOG KIT
49	angiomyoma	10.0	KIT ENO2
50	retroperitoneal hemangiopericytoma	10.0	KIT ENO2

Graphical network of the top 20 diseases related to Pineal Region Teratoma:

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Symptoms & Phenotypes for Pineal Region Teratoma

MGI Mouse Phenotypes related to Pineal Region Teratoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	8.92	AFP KIT MYOD1 SMARCB1

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Drugs & Therapeutics for Pineal Region Teratoma

Search Clinical Trials , NIH Clinical Center for Pineal Region Teratoma

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Genetic Tests for Pineal Region Teratoma

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Anatomical Context for Pineal Region Teratoma

MalaCards organs/tissues related to Pineal Region Teratoma:

⁴⁰

Pineal, Lung, Prostate, Liver, Breast, Ovary, Thymus

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Publications for Pineal Region Teratoma

Articles related to Pineal Region Teratoma:

#	Title	Authors	PMID	Year
1	Management of mature pineal region teratomas in pediatric age group. ⁶¹	Tanrikulu B...Ozek MM	31144023	2020
2	Midline Posterior Fossa Mature Teratoma in a Child. ⁶¹	Patil H...Garg N	30090150	2018
3	Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. ⁶¹	Cheng CM...Nieh S	16503489	2006

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Genes for Pineal Region Teratoma

Genes related to Pineal Region Teratoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AFP	Alpha Fetoprotein	Protein Coding	5.56	DISEASES inferred ¹⁵
2	MYOG	Myogenin	Protein Coding	4.34	DISEASES inferred ¹⁵
3	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	4.28	DISEASES inferred ¹⁵
4	MYOD1	Myogenic Differentiation 1	Protein Coding	4.2	DISEASES inferred ¹⁵
5	ENO2	Enolase 2	Protein Coding	3.74	DISEASES inferred ¹⁵
6	SYP	Synaptophysin	Protein Coding	3.68	DISEASES inferred ¹⁵
7	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Pineal Region Teratoma

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Expression for Pineal Region Teratoma

Search GEO for disease gene expression data for Pineal Region Teratoma.

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Pathways for Pineal Region Teratoma

Pathways related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Myogenesis ⁶⁵ Show member pathways CDO in myogenesis ⁶⁵	10.92	MYOG MYOD1
2	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.78	MYOG MYOD1 KIT
3	Regulation of retinoblastoma protein ¹	10.7	SMARCB1 MYOD1

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GO Terms for Pineal Region Teratoma

Biological processes related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	skeletal muscle tissue development	GO:0007519	9.49	MYOG MYOD1
2	skeletal muscle cell differentiation	GO:0035914	9.48	MYOG MYOD1
3	cellular response to estradiol stimulus	GO:0071392	9.46	MYOG MYOD1
4	positive regulation of muscle cell differentiation	GO:0051149	9.43	MYOG MYOD1
5	skeletal muscle fiber development	GO:0048741	9.4	MYOG MYOD1
6	skeletal muscle tissue regeneration	GO:0043403	9.37	MYOG MYOD1
7	positive regulation of myoblast differentiation	GO:0045663	9.32	MYOG MYOD1
8	myoblast differentiation	GO:0045445	9.26	MYOG MYOD1
9	myotube differentiation	GO:0014902	9.16	MYOG MYOD1
10	positive regulation of skeletal muscle fiber development	GO:0048743	8.96	MYOG MYOD1
11	muscle cell fate commitment	GO:0042693	8.62	MYOG MYOD1

Molecular functions related to Pineal Region Teratoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	E-box binding	GO:0070888	8.96	MYOG MYOD1
2	SH2 domain binding	GO:0042169	8.62	SYP KIT

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Sources for Pineal Region Teratoma

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⁵⁷ OMIM® (Updated 20-May-2021)

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⁶¹ PubMed

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⁷³ Wikipedia