MCID: PNB001
MIFTS: 52

Pineoblastoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pineoblastoma

MalaCards integrated aliases for Pineoblastoma:

Name: Pineoblastoma 12 53 59 55 6 15 73
Tumor of the Pineal Region 73
Pineal Gland Neoplasm 73
Pineal Pnet 12
Pineocytoma 73
Pinealoma 44

Characteristics:

Orphanet epidemiological data:

59
pineoblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 59  
Rare neurological diseases


Summaries for Pineoblastoma

NIH Rare Diseases : 53 Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  The pineal gland is located in the brain and makes the hormonemelatonin to regulate the body's sleep patterns.  Pineoblastoma is a type of primitive neuroectodermal tumor (PNET).  Pineoblastoma mainly affects children, but can also occur in adults.  Treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy.

MalaCards based summary : Pineoblastoma, also known as tumor of the pineal region, is related to seminoma and medulloepithelioma. An important gene associated with Pineoblastoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Melphalan and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and bone, and related phenotypes are seizures and behavioral abnormality

Disease Ontology : 12 A pineal gland neoplasm located in the brain.

Wikipedia : 76 Pinealoblastoma or pineoblastoma is a malignant tumor of the pineal gland. A pinealoblastoma is a... more...

Related Diseases for Pineoblastoma

Diseases in the Pineoblastoma family:

Adult Pineoblastoma

Diseases related to Pineoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 seminoma 30.0 AFP POU5F1
2 medulloepithelioma 29.8 GFAP SYP
3 pineocytoma 29.7 ASMT GFAP SAG SYP
4 teratoma 29.4 AFP GFAP POU5F1 SYP
5 pineal gland cancer 29.1 ASMT DICER1 GFAP SAG SYP
6 pineoblastoma, childhood 12.6
7 adult pineoblastoma 12.3
8 retinoblastoma 10.4
9 reproductive organ benign neoplasm 10.2 AFP DICER1
10 testicular granulosa cell tumor 10.2 AFP DICER1
11 juvenile type testicular granulosa cell tumor 10.2 AFP DICER1
12 sertoli-leydig cell tumor 10.2 AFP DICER1
13 malignant sertoli cell tumor 10.1 AFP SYP
14 brain germinoma 10.1 AFP POU5F1
15 extragonadal germ cell cancer 10.1 AFP POU5F1
16 germ cell cancer 10.1 AFP POU5F1
17 embryonal testis carcinoma 10.1 AFP POU5F1
18 ovarian embryonal carcinoma 10.1 AFP POU5F1
19 intratubular embryonal carcinoma 10.1 AFP POU5F1
20 pulmonary blastoma 10.1 DICER1 SYP
21 endometrial small cell carcinoma 10.1 AFP SYP
22 testicular infarct 10.1 AFP POU5F1
23 mediastinal cancer 10.1 AFP SYP
24 atypical choroid plexus papilloma 10.1 DICER1 SYP
25 seminal vesicle tumor 10.1 AFP SYP
26 mature teratoma 10.1 AFP POU5F1
27 embryoma 10.1 AFP POU5F1
28 pancreatoblastoma 10.1 AFP SYP
29 testicular disease 10.1 AFP DICER1
30 mixed germ cell cancer 10.1 AFP POU5F1
31 extragonadal seminoma 10.1 AFP POU5F1
32 medulloblastoma 10.1
33 unilateral retinoblastoma 10.1
34 ewing's family of tumors 10.1
35 venous hemangioma 10.1 POU5F1 SYP
36 tubular adenocarcinoma 10.1 AFP SYP
37 non-functioning pancreatic endocrine tumor 10.1 POU5F1 SYP
38 germ cell and embryonal cancer 10.0 AFP POU5F1
39 panophthalmitis 10.0 SAG SYP
40 melanotic medulloblastoma 10.0 AFP GFAP
41 testicular yolk sac tumor 10.0 AFP POU5F1
42 male reproductive organ benign neoplasm 10.0 AFP DICER1 SYP
43 sex cord-gonadal stromal tumor 10.0 AFP DICER1 SYP
44 ependymoma 10.0 GFAP SYP
45 desmoplastic infantile ganglioglioma 10.0 GFAP SYP
46 ganglioglioma 10.0 GFAP SYP
47 extraventricular neurocytoma 10.0 GFAP SYP
48 purulent endophthalmitis 10.0 SAG SYP
49 lung combined type small cell carcinoma 10.0 GFAP SYP
50 cellular ependymoma 10.0 GFAP SYP

Graphical network of the top 20 diseases related to Pineoblastoma:



Diseases related to Pineoblastoma

Symptoms & Phenotypes for Pineoblastoma

Human phenotypes related to Pineoblastoma:

59 32 (show all 19)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
2 behavioral abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0000708
3 increased intracranial pressure 59 32 frequent (33%) Frequent (79-30%) HP:0002516
4 sensory neuropathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000763
5 reduced visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0007663
6 memory impairment 59 32 frequent (33%) Frequent (79-30%) HP:0002354
7 amaurosis fugax 59 32 occasional (7.5%) Occasional (29-5%) HP:0100576
8 paralysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0003470
9 retinoblastoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0009919
10 papilledema 59 32 occasional (7.5%) Occasional (29-5%) HP:0001085
11 lethargy 59 32 very rare (1%) Very rare (<4-1%) HP:0001254
12 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
13 pinealoma 59 32 obligate (100%) Obligate (100%) HP:0010799
14 progressive neurologic deterioration 59 32 frequent (33%) Frequent (79-30%) HP:0002344
15 impaired convergence 59 32 occasional (7.5%) Occasional (29-5%) HP:0000619
16 midline brain calcifications 59 32 occasional (7.5%) Occasional (29-5%) HP:0007045
17 progressive visual field defects 59 32 occasional (7.5%) Occasional (29-5%) HP:0007987
18 reduced consciousness/confusion 59 Very rare (<4-1%)
19 cognitive impairment 59 Frequent (79-30%)

GenomeRNAi Phenotypes related to Pineoblastoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.36 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.36 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.36 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.36 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 POU5F1

MGI Mouse Phenotypes related to Pineoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.1 CADPS DICER1 GFAP POU5F1 SAG SYP

Drugs & Therapeutics for Pineoblastoma

Drugs for Pineoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 190)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 4053 460612
2
Carboplatin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
3
Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 52-24-4 5453
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 3,Not Applicable 6055-19-2, 50-18-0 2907
5
Etoposide Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 33419-42-0 36462
6
Cisplatin Approved Phase 3,Phase 2,Not Applicable 15663-27-1 2767 441203 84093
7
Vincristine Approved, Investigational Phase 3,Phase 2,Not Applicable 57-22-7, 2068-78-2 5978
8
leucovorin Approved Phase 3,Phase 2 58-05-9 6006 143
9
Methotrexate Approved Phase 3,Phase 2 59-05-2, 1959-05-2 126941
10
Lenograstim Approved, Investigational Phase 3,Phase 1 135968-09-1
11
Temozolomide Approved, Investigational Phase 3,Phase 1,Phase 2 85622-93-1 5394
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
13
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
14
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
15
Ondansetron Approved Phase 3 99614-02-5 4595
16
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
17
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
19 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
20 Etoposide phosphate Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
21 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2,Not Applicable
22 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
23 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
24 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
25 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
26 Vitamin B Complex Phase 3,Phase 2
27 Alkylating Agents Phase 3,Phase 1,Phase 2,Not Applicable
28 Dermatologic Agents Phase 3,Phase 2,Phase 1,Not Applicable
29 Folic Acid Antagonists Phase 3,Phase 2
30 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
31 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
32 Antimetabolites Phase 3,Phase 2,Phase 1
33 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
34 Folate Phase 3,Phase 2
35 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
36 Vitamin B9 Phase 3,Phase 2
37 Cola Phase 3,Phase 1
38 Central Nervous System Depressants Phase 3,Phase 2
39 Adjuvants, Anesthesia Phase 3
40 Liver Extracts Phase 3,Phase 1,Phase 2
41 Anesthetics, Intravenous Phase 3
42 Analgesics, Opioid Phase 3
43 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
44 Anesthetics, General Phase 3
45 Analgesics Phase 3,Phase 2,Phase 1
46 Narcotics Phase 3
47 Anesthetics Phase 3
48 Neurotransmitter Agents Phase 3,Phase 2
49 Nootropic Agents Phase 3,Phase 2
50 Cholinergic Agents Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
5 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
6 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
7 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
8 Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors Completed NCT00006450 Phase 2 Phenylbutyrate
9 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Completed NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
10 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
11 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
12 Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma Recruiting NCT02596828 Phase 2 Temozolomide;Irinotecan;Dasatinib;Rapamycin
13 Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Recruiting NCT02095132 Phase 1, Phase 2 Adavosertib;Irinotecan Hydrochloride
14 Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Active, not recruiting NCT01217437 Phase 2 Irinotecan Hydrochloride;Temozolomide
15 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
16 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2 Induction Chemotherapy;Low-Risk Therapy;High-Risk Therapy;Intermediate-Risk Therapy
17 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
18 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
19 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
20 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
21 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
22 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
23 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
24 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
25 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
26 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
27 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
28 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
29 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
30 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
31 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
32 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
33 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
34 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
35 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
36 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
37 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
38 Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors Completed NCT00503724 Phase 1 enzastaurin hydrochloride
39 EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors Recruiting NCT03638167 Phase 1
40 HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors Recruiting NCT03500991 Phase 1
41 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
42 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Recruiting NCT02255461 Phase 1 palbociclib isethionate
43 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride
44 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
45 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
46 Melphalan With BBBD in Treating Patients With Brain Malignancies Terminated NCT00253721 Phase 1 Melphalan
47 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
48 MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer Terminated NCT00572182 Phase 1 MK-0752
49 Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors Terminated NCT00112619 Phase 1 topotecan hydrochloride
50 Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment Withdrawn NCT00458744 Phase 1 talotrexin

Search NIH Clinical Center for Pineoblastoma

Cochrane evidence based reviews: pinealoma

Genetic Tests for Pineoblastoma

Anatomical Context for Pineoblastoma

MalaCards organs/tissues related to Pineoblastoma:

41
Pineal, Brain, Bone, Liver, Lung, Thymus, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Pineoblastoma:

19
The Brain

Publications for Pineoblastoma

Articles related to Pineoblastoma:

(show top 50) (show all 154)
# Title Authors Year
1
Papillary tumor of the pineal region: Case report and review of the literature. ( 29691144 )
2018
2
Papillary tumor of the pineal region in children: presentation of a case and comprehensive literature review. ( 29906576 )
2018
3
Retrospective Analysis of the Clinical Characteristics, Therapeutic Aspects, and Prognostic Factors of 18 Cases of Childhood Pineoblastoma. ( 29709740 )
2018
4
Papillary tumor of the pineal region accompanied by Parinaud's syndrome: magnetic resonance imaging findings. ( 29991845 )
2018
5
Recurrent Pineocytomalike Papillary Tumor of The Pineal Region: A Case Report and Literature Review. ( 30165231 )
2018
6
Durable response to mTOR inhibition in a patient with relapsing papillary tumor of the pineal region. ( 30295836 )
2018
7
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. ( 30030436 )
2018
8
Prognosis of Pediatric Patients with Pineoblastoma: A SEER Analysis 1990-2013. ( 30031180 )
2018
9
Pineoblastoma in a child with 22q11.2 deletion syndrome. ( 30217803 )
2018
10
Masson's tumor of the pineal region: case report. ( 28777021 )
2018
11
A Case of Nongerminomatous Germ Cell Tumor of the Pineal Region: Risks and Advantages of Biopsy by Endoscopic Approach. ( 29713348 )
2018
12
Pineoblastoma-The Experience at St. Jude Children's Research Hospital. ( 28327927 )
2017
13
Nuclear CRX and FOXJ1 Expression Differentiates Non-Germ Cell Pineal Region Tumors and Supports the Ependymal Differentiation of Papillary Tumor of the Pineal Region. ( 28719464 )
2017
14
Papillary Tumor of the Pineal Region: A Distinct Molecular Entity. ( 26113311 )
2016
15
Late dissemination via cerebrospinal fluid of papillary tumor of the pineal region: a case report and literature review. ( 27179224 )
2016
16
Increased VEGF levels in one case of papillary tumor of the pineal region with intracranial haemorrhage at presentation: a potential surrogate indicator of tumor angiogenesis and aggressiveness? ( 26745494 )
2016
17
Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data. ( 28011926 )
2016
18
Cytologic features of papillary tumor of the pineal region: A case report showing tigroid background. ( 27535020 )
2016
19
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part II, the cystic gland. ( 27130617 )
2016
20
A case of papillary tumor of the pineal region with a long clinical history: molecular characterization and therapeutic consideration with review of the literature. ( 27472995 )
2016
21
Atypical Teratoid/Rhabdoid Tumor of the Pineal Region in a Young Adult Male Patient: Case Report and Review of the Literature. ( 27144539 )
2016
22
Isolation and characterization of tumorspheres from a recurrent pineoblastoma patient: Feasibility of a patient-derived xenograft. ( 27277549 )
2016
23
A rare case of a pineoblastoma with a rhabdomyoblastic component. ( 27775846 )
2016
24
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part I, the solid gland. ( 27130616 )
2016
25
Long-term follow-up of a papillary tumor of the pineal region: addendum to a case report. ( 27568037 )
2016
26
Clinical Reasoning: Left hemiparesis, ataxia, and optic neuritis in a child previously treated for pineoblastoma. ( 27163667 )
2016
27
Magnetic resonance imaging based morphologic evaluation of the pineal gland for suspected pineoblastoma in retinoblastoma patients and age-matched controls. ( 26671110 )
2015
28
Papillary tumor of the pineal region with extended clinical and radiologic follow-up. ( 26539320 )
2015
29
Lack of BRAF-V600E Mutation in Papillary Tumor of the Pineal Region. ( 26125673 )
2015
30
Papillary tumor of the pineal region-report of three cases with literature review. ( 26238893 )
2015
31
Papillary tumor of the pineal region presenting with Foster Kennedy sign. ( 26183673 )
2015
32
The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma. ( 25690449 )
2015
33
Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. ( 26622845 )
2015
34
Papillary tumor of the pineal region: A case report and review of the literature. ( 26622493 )
2015
35
Papillary tumor of the pineal region: Histopathological characterization and review of the literature. ( 24556386 )
2015
36
Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features. ( 26068071 )
2015
37
Leptomeningeal metastases in pineoblastoma. ( 26123467 )
2015
38
Outcomes After Surgery and Radiotherapy for Papillary Tumor of the Pineal Region. ( 25749579 )
2015
39
A Case of Radiation-Induced Osteosarcoma after the Treatment of Pineoblastoma. ( 26605276 )
2015
40
Papillary Tumor of the Pineal Region: MR Signal Intensity Correlated to Histopathology. ( 25688307 )
2015
41
Intraosseous Metastasizing of Pineoblastoma into the Anterior Skull Base, Calvarial Bones, and Vertebrae. ( 26858918 )
2015
42
Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-year Single Institution Retrospective Review. ( 25045788 )
2014
43
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
44
Papillary tumor of the pineal region. Report of two cases and literature review. ( 25440015 )
2014
45
Germ-line and somatic DICER1 mutations in pineoblastoma. ( 25022261 )
2014
46
Stereotactic radiosurgery of a papillary tumor of the pineal region: case report and review of the literature. ( 23446182 )
2013
47
Bevacizumab is Effective for Recurrent Papillary Tumor of the Pineal Region: First Report. ( 24019784 )
2013
48
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 23876864 )
2013
49
Papillary tumor of the pineal region with anaplastic small cell component. ( 23817812 )
2013
50
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 24238207 )
2013

Variations for Pineoblastoma

ClinVar genetic disease variations for Pineoblastoma:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 DICER1 NM_177438.2(DICER1): c.5103C> A (p.Tyr1701Ter) single nucleotide variant Pathogenic rs875989780 GRCh38 Chromosome 14, 95094149: 95094149
2 DICER1 NM_177438.2(DICER1): c.5103C> A (p.Tyr1701Ter) single nucleotide variant Pathogenic rs875989780 GRCh37 Chromosome 14, 95560486: 95560486
3 DICER1 NM_177438.2(DICER1): c.4754C> G (p.Ser1585Ter) single nucleotide variant Pathogenic rs875989779 GRCh37 Chromosome 14, 95562503: 95562503
4 DICER1 NM_177438.2(DICER1): c.4754C> G (p.Ser1585Ter) single nucleotide variant Pathogenic rs875989779 GRCh38 Chromosome 14, 95096166: 95096166
5 DICER1 NM_177438.2(DICER1): c.4633dupT (p.Ser1545Phefs) duplication Pathogenic rs875989781 GRCh38 Chromosome 14, 95096287: 95096287
6 DICER1 NM_177438.2(DICER1): c.4633dupT (p.Ser1545Phefs) duplication Pathogenic rs875989781 GRCh37 Chromosome 14, 95562624: 95562624
7 DICER1 NM_177438.2(DICER1): c.4407_4410delTTCT (p.Ser1470Leufs) deletion Pathogenic rs875989784 GRCh37 Chromosome 14, 95562847: 95562850
8 DICER1 NM_177438.2(DICER1): c.4407_4410delTTCT (p.Ser1470Leufs) deletion Pathogenic rs875989784 GRCh38 Chromosome 14, 95096510: 95096513
9 DICER1 NM_177438.2(DICER1): c.4050+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs875989783 GRCh38 Chromosome 14, 95103345: 95103345
10 DICER1 NM_177438.2(DICER1): c.4050+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs875989783 GRCh37 Chromosome 14, 95569682: 95569682
11 DICER1 NM_177438.2(DICER1): c.1498A> T (p.Lys500Ter) single nucleotide variant Pathogenic rs875989782 GRCh38 Chromosome 14, 95117633: 95117633
12 DICER1 NM_177438.2(DICER1): c.1498A> T (p.Lys500Ter) single nucleotide variant Pathogenic rs875989782 GRCh37 Chromosome 14, 95583970: 95583970

Expression for Pineoblastoma

Search GEO for disease gene expression data for Pineoblastoma.

Pathways for Pineoblastoma

Pathways related to Pineoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 GFAP SAG SYP
2 10.85 GFAP SYP

GO Terms for Pineoblastoma

Biological processes related to Pineoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 8.62 GFAP POU5F1

Sources for Pineoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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