MCID: PNB001
MIFTS: 51

Pineoblastoma

Categories: Rare diseases, Neuronal diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Pineoblastoma

MalaCards integrated aliases for Pineoblastoma:

Name: Pineoblastoma 12 53 59 55 6 15 73
Tumor of the Pineal Region 73
Pineal Gland Neoplasm 73
Pineal Pnet 12
Pineocytoma 73
Pinealoma 44

Characteristics:

Orphanet epidemiological data:

59
pineoblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 59  
Rare neurological diseases


Summaries for Pineoblastoma

NIH Rare Diseases : 53 Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  The pineal gland is located in the brain and makes the hormonemelatonin to regulate the body's sleep patterns.  Pineoblastoma is a type of primitive neuroectodermal tumor (PNET).  Pineoblastoma mainly affects children, but can also occur in adults.  Treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy.

MalaCards based summary : Pineoblastoma, also known as tumor of the pineal region, is related to medulloepithelioma and pineocytoma. An important gene associated with Pineoblastoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include the brain, pineal and brain, and related phenotypes are pinealoma and headache

Disease Ontology : 12 A pineal gland neoplasm located in the brain.

Related Diseases for Pineoblastoma

Diseases in the Pineoblastoma family:

Adult Pineoblastoma

Diseases related to Pineoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 medulloepithelioma 29.4 GFAP SYP
2 pineocytoma 28.1 ASMT GFAP SAG SYP
3 pineal gland cancer 27.0 ASMT DICER1 GFAP SAG SYP
4 pineoblastoma, childhood 12.4
5 adult pineoblastoma 12.1
6 testicular granulosa cell tumor 10.6 AFP DICER1
7 juvenile type testicular granulosa cell tumor 10.6 AFP DICER1
8 sertoli-leydig cell tumor 10.5 AFP DICER1
9 embryoma 10.5 DICER1 SYP
10 malignant sertoli cell tumor 10.4 AFP SYP
11 brain germinoma 10.4 AFP POU5F1
12 extragonadal germ cell cancer 10.4 AFP POU5F1
13 reproductive organ benign neoplasm 10.4 AFP DICER1
14 embryonal testis carcinoma 10.4 AFP POU5F1
15 ovarian embryonal carcinoma 10.4 AFP POU5F1
16 pulmonary blastoma 10.4 DICER1 SYP
17 intratubular embryonal carcinoma 10.4 AFP POU5F1
18 atypical choroid plexus papilloma 10.4 DICER1 SYP
19 endometrial small cell carcinoma 10.4 AFP SYP
20 testicular infarct 10.3 AFP POU5F1
21 mediastinal cancer 10.3 AFP SYP
22 mature teratoma 10.3 AFP POU5F1
23 seminal vesicle tumor 10.3 AFP SYP
24 pancreatoblastoma 10.3 AFP SYP
25 mixed germ cell cancer 10.2 AFP POU5F1
26 pancreatic cystadenocarcinoma 10.2 AFP SYP
27 venous hemangioma 10.2 POU5F1 SYP
28 extragonadal seminoma 10.2 AFP POU5F1
29 retinoblastoma 10.2
30 non-functioning pancreatic endocrine tumor 10.2 POU5F1 SYP
31 germ cell and embryonal cancer 10.1 AFP POU5F1
32 aging 10.1
33 ewing's family of tumors 10.1
34 melanotic medulloblastoma 10.1 AFP GFAP
35 sex cord-gonadal stromal tumor 10.0 AFP DICER1 SYP
36 testicular yolk sac tumor 10.0 AFP POU5F1
37 desmoplastic infantile ganglioglioma 9.9 GFAP SYP
38 extraventricular neurocytoma 9.9 GFAP SYP
39 lung combined type small cell carcinoma 9.9 GFAP SYP
40 cellular ependymoma 9.9 GFAP SYP
41 gangliocytoma 9.9 GFAP SYP
42 medulloblastoma 9.9
43 unilateral retinoblastoma 9.9
44 rhabdoid meningioma 9.9 GFAP SYP
45 pilomyxoid astrocytoma 9.9 GFAP SYP
46 chordoid meningioma 9.9 GFAP SYP
47 subependymal glioma 9.9 GFAP SYP
48 chiari malformation 9.9 GFAP SYP
49 dysembryoplastic neuroepithelial tumor 9.9 GFAP SYP
50 cerebral neuroblastoma 9.9 GFAP SYP

Graphical network of the top 20 diseases related to Pineoblastoma:



Diseases related to Pineoblastoma

Symptoms & Phenotypes for Pineoblastoma

Human phenotypes related to Pineoblastoma:

59 32 (show all 19)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pinealoma 59 32 obligate (100%) Obligate (100%) HP:0010799
2 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
3 behavioral abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0000708
4 progressive neurologic deterioration 59 32 frequent (33%) Frequent (79-30%) HP:0002344
5 memory impairment 59 32 frequent (33%) Frequent (79-30%) HP:0002354
6 increased intracranial pressure 59 32 frequent (33%) Frequent (79-30%) HP:0002516
7 impaired convergence 59 32 occasional (7.5%) Occasional (29-5%) HP:0000619
8 sensory neuropathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000763
9 papilledema 59 32 occasional (7.5%) Occasional (29-5%) HP:0001085
10 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
11 paralysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0003470
12 midline brain calcifications 59 32 occasional (7.5%) Occasional (29-5%) HP:0007045
13 reduced visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0007663
14 progressive visual field defects 59 32 occasional (7.5%) Occasional (29-5%) HP:0007987
15 retinoblastoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0009919
16 amaurosis fugax 59 32 occasional (7.5%) Occasional (29-5%) HP:0100576
17 lethargy 59 32 very rare (1%) Very rare (<4-1%) HP:0001254
18 cognitive impairment 59 Frequent (79-30%)
19 reduced consciousness/confusion 59 Very rare (<4-1%)

GenomeRNAi Phenotypes related to Pineoblastoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.36 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.36 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.36 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.36 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 POU5F1

MGI Mouse Phenotypes related to Pineoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.1 CADPS DICER1 GFAP POU5F1 SAG SYP

Drugs & Therapeutics for Pineoblastoma

Drugs for Pineoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 190)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 3,Not Applicable 50-18-0, 6055-19-2 2907
3
Etoposide Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 33419-42-0 36462
4
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 4053 460612
5
Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 52-24-4 5453
6
Cisplatin Approved Phase 3,Phase 2,Not Applicable 15663-27-1 84093 441203 2767
7
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
8
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
9
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1 85622-93-1 5394
10
Vincristine Approved, Investigational Phase 3,Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
14
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
15
Ondansetron Approved Phase 3 99614-02-5 4595
16
Isotretinoin Approved Phase 3,Not Applicable 4759-48-2 5538 5282379
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
19 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
20 Etoposide phosphate Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
21 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
22 Antimetabolites Phase 3,Phase 2
23 Antimetabolites, Antineoplastic Phase 3,Phase 2
24 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
25 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable
26 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
27 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
28 Dermatologic Agents Phase 3,Phase 2,Phase 1,Not Applicable
29 Folic Acid Antagonists Phase 3,Phase 2
30 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
31 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
32 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
33 Vitamin B Complex Phase 3,Phase 2
34 Adjuvants, Anesthesia Phase 3
35 Analgesics Phase 3,Phase 2,Phase 1
36 Analgesics, Opioid Phase 3
37 Anesthetics Phase 3
38 Anesthetics, General Phase 3
39 Anesthetics, Intravenous Phase 3
40 Central Nervous System Depressants Phase 3,Phase 2
41 Liver Extracts Phase 3,Phase 1,Phase 2
42 Narcotics Phase 3
43 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
44 Cholinergic Agents Phase 3,Phase 2
45 Cholinesterase Inhibitors Phase 3,Phase 2
46 Neurotransmitter Agents Phase 3,Phase 2
47 Nootropic Agents Phase 3,Phase 2
48 Antiemetics Phase 3,Phase 1
49 Autonomic Agents Phase 3,Phase 1
50 BB 1101 Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 80)
# Name Status NCT ID Phase Drugs
1 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
5 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
6 Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma Recruiting NCT00392327 Phase 3 Vincristine Sulfate;Carboplatin;Cisplatin;Cyclophosphamide;Isotretinoin
7 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
8 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
9 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
10 Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors Completed NCT00006450 Phase 2 Phenylbutyrate
11 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
12 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
13 Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors Completed NCT00025077 Phase 2 carboplatin;cyclophosphamide;thiotepa
14 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
15 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
16 Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma Recruiting NCT02596828 Phase 2 Temozolomide;Irinotecan;Dasatinib;Rapamycin
17 Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Active, not recruiting NCT01217437 Phase 2 Irinotecan Hydrochloride;Temozolomide
18 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Active, not recruiting NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
19 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
20 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2 Induction Chemotherapy;Low-Risk Therapy;High-Risk Therapy;Intermediate-Risk Therapy
21 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
22 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
23 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
24 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
25 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
26 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
27 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
28 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
29 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
30 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
31 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
32 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
33 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
34 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
35 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
36 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
37 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
38 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
39 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
40 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
41 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
42 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
43 Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors Completed NCT00503724 Phase 1 enzastaurin hydrochloride
44 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
45 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
46 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
47 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
48 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
49 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Recruiting NCT02255461 Phase 1 palbociclib isethionate
50 Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors Recruiting NCT02780804 Phase 1 Entinostat

Search NIH Clinical Center for Pineoblastoma

Cochrane evidence based reviews: pinealoma

Genetic Tests for Pineoblastoma

Anatomical Context for Pineoblastoma

The Foundational Model of Anatomy Ontology organs/tissues related to Pineoblastoma:

19
The Brain

MalaCards organs/tissues related to Pineoblastoma:

41
Pineal, Brain, Bone, Bone Marrow, Spinal Cord, Liver, Endothelial

Publications for Pineoblastoma

Articles related to Pineoblastoma:

(show top 50) (show all 127)
# Title Authors Year
1
Papillary tumor of the pineal region: Case report and review of the literature. ( 29691144 )
2018
2
Papillary tumor of the pineal region in children: presentation of a case and comprehensive literature review. ( 29906576 )
2018
3
Retrospective Analysis of the Clinical Characteristics, Therapeutic Aspects, and Prognostic Factors of 18 Cases of Childhood Pineoblastoma. ( 29709740 )
2018
4
Pineoblastoma-The Experience at St. Jude Children's Research Hospital. ( 28327927 )
2017
5
Nuclear CRX and FOXJ1 Expression Differentiates Non-Germ Cell Pineal Region Tumors and Supports the Ependymal Differentiation of Papillary Tumor of the Pineal Region. ( 28719464 )
2017
6
Papillary Tumor of the Pineal Region: A Distinct Molecular Entity. ( 26113311 )
2016
7
Late dissemination via cerebrospinal fluid of papillary tumor of the pineal region: a case report and literature review. ( 27179224 )
2016
8
Increased VEGF levels in one case of papillary tumor of the pineal region with intracranial haemorrhage at presentation: a potential surrogate indicator of tumor angiogenesis and aggressiveness? ( 26745494 )
2016
9
Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data. ( 28011926 )
2016
10
Cytologic features of papillary tumor of the pineal region: A case report showing tigroid background. ( 27535020 )
2016
11
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part II, the cystic gland. ( 27130617 )
2016
12
A case of papillary tumor of the pineal region with a long clinical history: molecular characterization and therapeutic consideration with review of the literature. ( 27472995 )
2016
13
Atypical Teratoid/Rhabdoid Tumor of the Pineal Region in a Young Adult Male Patient: Case Report and Review of the Literature. ( 27144539 )
2016
14
Isolation and characterization of tumorspheres from a recurrent pineoblastoma patient: Feasibility of a patient-derived xenograft. ( 27277549 )
2016
15
A rare case of a pineoblastoma with a rhabdomyoblastic component. ( 27775846 )
2016
16
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part I, the solid gland. ( 27130616 )
2016
17
Long-term follow-up of a papillary tumor of the pineal region: addendum to a case report. ( 27568037 )
2016
18
Clinical Reasoning: Left hemiparesis, ataxia, and optic neuritis in a child previously treated for pineoblastoma. ( 27163667 )
2016
19
Magnetic resonance imaging based morphologic evaluation of the pineal gland for suspected pineoblastoma in retinoblastoma patients and age-matched controls. ( 26671110 )
2015
20
Papillary tumor of the pineal region with extended clinical and radiologic follow-up. ( 26539320 )
2015
21
Lack of BRAF-V600E Mutation in Papillary Tumor of the Pineal Region. ( 26125673 )
2015
22
Papillary tumor of the pineal region-report of three cases with literature review. ( 26238893 )
2015
23
Papillary tumor of the pineal region presenting with Foster Kennedy sign. ( 26183673 )
2015
24
The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma. ( 25690449 )
2015
25
Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. ( 26622845 )
2015
26
Papillary tumor of the pineal region: A case report and review of the literature. ( 26622493 )
2015
27
Papillary tumor of the pineal region: Histopathological characterization and review of the literature. ( 24556386 )
2015
28
Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features. ( 26068071 )
2015
29
Leptomeningeal metastases in pineoblastoma. ( 26123467 )
2015
30
Outcomes After Surgery and Radiotherapy for Papillary Tumor of the Pineal Region. ( 25749579 )
2015
31
A Case of Radiation-Induced Osteosarcoma after the Treatment of Pineoblastoma. ( 26605276 )
2015
32
Papillary Tumor of the Pineal Region: MR Signal Intensity Correlated to Histopathology. ( 25688307 )
2015
33
Intraosseous Metastasizing of Pineoblastoma into the Anterior Skull Base, Calvarial Bones, and Vertebrae. ( 26858918 )
2015
34
Is CRX protein a useful marker in differential diagnosis of tumors of the pineal region? ( 24555912 )
2014
35
Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-year Single Institution Retrospective Review. ( 25045788 )
2014
36
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
37
Papillary tumor of the pineal region. Report of two cases and literature review. ( 25440015 )
2014
38
Germ-line and somatic DICER1 mutations in pineoblastoma. ( 25022261 )
2014
39
PTEN mutations and activation of the PI3K/Akt/mTOR signaling pathway in papillary tumors of the pineal region. ( 25003235 )
2014
40
Stereotactic radiosurgery of a papillary tumor of the pineal region: case report and review of the literature. ( 23446182 )
2013
41
Bevacizumab is Effective for Recurrent Papillary Tumor of the Pineal Region: First Report. ( 24019784 )
2013
42
CRX/OTX3: a useful marker in the differential diagnosis of tumors of the pineal region and indicator of photoreceptor differentiation in medulloblastomas and atypical teratoid rhabdoid tumors. ( 23235340 )
2013
43
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 23876864 )
2013
44
Papillary tumor of the pineal region with anaplastic small cell component. ( 23817812 )
2013
45
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 24238207 )
2013
46
Early treatment response of a rare papillary tumor of the pineal region after primary proton-beam therapy using the raster-scanning technique at HIT. ( 23235766 )
2012
47
Donor transmission of pineoblastoma in a two-yr-old male recipient of a multivisceral transplant: a case report. ( 21281415 )
2012
48
The long-term postsurgical prognosis of patients with pineoblastoma. ( 21717450 )
2012
49
Histopathologic and ultrastructural features and claudin expression in papillary tumors of the pineal region: a multicenter analysis. ( 22588068 )
2012
50
Germline DICER1 mutation and associated loss of heterozygosity in a pineoblastoma. ( 22717647 )
2012

Variations for Pineoblastoma

ClinVar genetic disease variations for Pineoblastoma:

6
(show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 DICER1 NM_177438.2(DICER1): c.5103C> A (p.Tyr1701Ter) single nucleotide variant Pathogenic rs875989780 GRCh38 Chromosome 14, 95094149: 95094149
2 DICER1 NM_177438.2(DICER1): c.5103C> A (p.Tyr1701Ter) single nucleotide variant Pathogenic rs875989780 GRCh37 Chromosome 14, 95560486: 95560486
3 DICER1 NM_177438.2(DICER1): c.4754C> G (p.Ser1585Ter) single nucleotide variant Pathogenic rs875989779 GRCh37 Chromosome 14, 95562503: 95562503
4 DICER1 NM_177438.2(DICER1): c.4754C> G (p.Ser1585Ter) single nucleotide variant Pathogenic rs875989779 GRCh38 Chromosome 14, 95096166: 95096166
5 DICER1 NM_177438.2(DICER1): c.4633dupT (p.Ser1545Phefs) duplication Pathogenic rs875989781 GRCh38 Chromosome 14, 95096287: 95096287
6 DICER1 NM_177438.2(DICER1): c.4633dupT (p.Ser1545Phefs) duplication Pathogenic rs875989781 GRCh37 Chromosome 14, 95562624: 95562624
7 DICER1 NM_177438.2(DICER1): c.4407_4410delTTCT (p.Ser1470Leufs) deletion Pathogenic rs875989784 GRCh37 Chromosome 14, 95562847: 95562850
8 DICER1 NM_177438.2(DICER1): c.4407_4410delTTCT (p.Ser1470Leufs) deletion Pathogenic rs875989784 GRCh38 Chromosome 14, 95096510: 95096513
9 DICER1 NM_177438.2(DICER1): c.4050+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs875989783 GRCh38 Chromosome 14, 95103345: 95103345
10 DICER1 NM_177438.2(DICER1): c.4050+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs875989783 GRCh37 Chromosome 14, 95569682: 95569682
11 DICER1 NM_177438.2(DICER1): c.1498A> T (p.Lys500Ter) single nucleotide variant Pathogenic rs875989782 GRCh38 Chromosome 14, 95117633: 95117633
12 DICER1 NM_177438.2(DICER1): c.1498A> T (p.Lys500Ter) single nucleotide variant Pathogenic rs875989782 GRCh37 Chromosome 14, 95583970: 95583970

Expression for Pineoblastoma

Search GEO for disease gene expression data for Pineoblastoma.

Pathways for Pineoblastoma

Pathways related to Pineoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 GFAP SAG SYP
2 10.85 GFAP SYP

GO Terms for Pineoblastoma

Biological processes related to Pineoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 8.62 GFAP POU5F1

Sources for Pineoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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