Aliases & Classifications for Pinguecula

MalaCards integrated aliases for Pinguecula:

Name: Pinguecula 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11029
ICD10 33 H11.15
ICD9CM 35 372.51
MeSH 44 D059407
UMLS 73 C0152255

Summaries for Pinguecula

MalaCards based summary : Pinguecula is related to basal cell carcinoma, infundibulocystic and large cell acanthoma. An important gene associated with Pinguecula is KRT10 (Keratin 10), and among its related pathways/superpathways are DNA Damage and Keratinization. Affiliated tissues include eye and thyroid, and related phenotypes are cellular and behavior/neurological

Wikipedia : 76 A pinguecula is a common type of conjunctival degeneration in the... more...

Related Diseases for Pinguecula

Diseases related to Pinguecula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma, infundibulocystic 10.8 KRT10 KRT14
2 large cell acanthoma 10.8 KRT10 KRT14
3 predominantly cortical thymoma 10.8 KRT14 KRT19
4 steatocystoma multiplex 10.7 KRT10 KRT16
5 ameloblastic carcinoma 10.7 KRT14 TP63
6 bowen's disease 10.7 KRT10 KRT16
7 epidermolysis bullosa simplex with mottled pigmentation 10.7 KRT10 KRT14
8 ichthyosis bullosa of siemens 10.7 KRT10 KRT14 KRT16
9 intraneural perineurioma 10.7 KRT10 KRT14 KRT19
10 lipoadenoma 10.6 KRT14 KRT19 TP63
11 squamous cell carcinoma of the oral tongue 10.6 KRT10 KRT16
12 striate palmoplantar keratoderma 10.5 KRT10 KRT14
13 anal gland adenocarcinoma 10.5 KRT19 MUC5AC
14 white sponge nevus 1 10.4 KRT10 KRT14 KRT16 KRT19
15 primary cutaneous amyloidosis 10.4 KRT10 KRT14 KRT16 KRT19
16 anus adenocarcinoma 10.4 KRT19 MUC5AC
17 type i 10.4 KRT10 KRT14 KRT16 KRT19
18 cataract 24 10.3 CRYAA TP53
19 breast squamous cell carcinoma 10.2 KRT10 KRT14 TP53
20 mucoepidermoid carcinoma 10.2 KRT14 MUC5AC TP63
21 keratoacanthoma 10.2 KRT10 KRT16 TP53
22 spiradenoma 10.1 KRT14 TP53
23 lichen planus 10.1 KRT10 KRT16 TP53
24 pleomorphic adenoma 10.1 KRT14 TP53 TP63
25 aging 10.1
26 cataract 10.0
27 limbal stem cell deficiency 10.0 KRT14 KRT19 MUC5AC TP63
28 phacolytic glaucoma 10.0 CD68 CRYAA
29 liver angiosarcoma 10.0 CYP2E1 KRT19 TP53
30 papilloma 9.9 KRT10 KRT14 TP53 TP63
31 anal canal adenocarcinoma 9.9 KRT19 MUC5AC
32 adenoid cystic carcinoma 9.9 KRT14 KRT19 TP53 TP63
33 arcus corneae 9.8
34 macular degeneration, age-related, 1 9.8
35 diabetes mellitus 9.8
36 keratopathy 9.8
37 systemic mastocytosis 9.8
38 melanoma 9.8
39 gaucher's disease 9.8
40 conjunctivochalasis 9.8
41 thyroiditis 9.8
42 oral cancer 9.8 CYP1A1 KRT19 TP53
43 biliary papillomatosis 9.8 KRT19 MUC5AC TP53
44 hidradenocarcinoma 9.8 MUC5AC TP53 TP63
45 bile duct adenocarcinoma 9.8 KRT19 MUC5AC TP53
46 intrahepatic cholangiocarcinoma 9.7 KRT19 MUC5AC TP53
47 pancreas adenocarcinoma 9.6 KRT19 MUC5AC TP53
48 lung squamous cell carcinoma 9.5 CYP1A1 KRT19 TP53 TP63
49 sarcomatoid squamous cell skin carcinoma 9.5 CD68 TP53
50 bladder carcinoma in situ 9.4 CD68 KRT19 TP53

Graphical network of the top 20 diseases related to Pinguecula:



Diseases related to Pinguecula

Symptoms & Phenotypes for Pinguecula

MGI Mouse Phenotypes related to Pinguecula:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 DCLRE1C KRT16 ITGB1 KRT14 TGM2 KRT19
2 behavior/neurological MP:0005386 10.26 CYP2E1 KRT16 ITGB1 LDLR TGM2 MUC5AC
3 endocrine/exocrine gland MP:0005379 10.24 DCLRE1C ITGB1 KRT19 CYP1A1 KRT14 TP53
4 homeostasis/metabolism MP:0005376 10.23 KRT14 KRT16 ITGB1 CYP1A1 CYP2E1 LDLR
5 growth/size/body region MP:0005378 10.22 KRT14 KRT16 ITGB1 CYP1A1 LDLR TGM2
6 immune system MP:0005387 10.21 DCLRE1C ITGB1 CD68 CYP1A1 KRT14 TGM2
7 cardiovascular system MP:0005385 10.2 ITGB1 CYP1A1 CYP2E1 LDLR TGM2 KRT19
8 digestive/alimentary MP:0005381 10.16 KRT16 ITGB1 KRT19 KRT14 MUC5AC TP53
9 mortality/aging MP:0010768 10.15 KRT14 KRT16 ITGB1 CYP1A1 CYP2E1 LDLR
10 craniofacial MP:0005382 10.07 KRT16 ITGB1 KRT14 PAX6 TP63 TP53
11 integument MP:0010771 10.06 KRT16 ITGB1 KRT14 KRT19 PAX6 LDLR
12 neoplasm MP:0002006 9.97 ITGB1 KRT19 KRT14 CYP2E1 TP53 PAX6
13 no phenotypic analysis MP:0003012 9.8 CD68 CYP1A1 LDLR TGM2 KRT19 TP63
14 normal MP:0002873 9.76 ITGB1 CYP1A1 LDLR KRT19 PAX6 TP63
15 pigmentation MP:0001186 9.43 ITGB1 KRT14 TP53 PAX6 LDLR XPA
16 vision/eye MP:0005391 9.23 ITGB1 KRT14 MUC5AC PAX6 LDLR TP63

Drugs & Therapeutics for Pinguecula

Search Clinical Trials , NIH Clinical Center for Pinguecula

Cochrane evidence based reviews: pinguecula

Genetic Tests for Pinguecula

Anatomical Context for Pinguecula

MalaCards organs/tissues related to Pinguecula:

41
Eye, Thyroid

Publications for Pinguecula

Articles related to Pinguecula:

(show top 50) (show all 54)
# Title Authors Year
1
Resolution of pinguecula-related dry eye disease after argon laser photocoagulation. ( 28769593 )
2017
2
Vascular Regression After Pinguecula Excision and Conjunctival Autograft Using Fibrin Glue. ( 27058827 )
2016
3
Prevalence and associated factors of pinguecula in a rural population in shanghai, eastern china. ( 25777313 )
2015
4
Significance of Fuchs Flecks in Patients With Pterygium/Pinguecula: Earliest Indicator of Ultraviolet Light Damage. ( 26398157 )
2015
5
Relationship between pinguecula formation and exposure to tandoor ovens in a hospital-based study. ( 25540757 )
2014
6
Unusual large uniocular elastoid and collagenous pinguecula. ( 24807233 )
2014
7
Intra-lesional injection of betamethasone for the treatment of symptomatic pinguecula. ( 24269437 )
2013
8
One-year outcome of argon laser photocoagulation of pinguecula. ( 23449487 )
2013
9
The prevalence and determinants of pterygium and pinguecula in an urban population in Shahroud, Iran. ( 23275285 )
2012
10
Prevalence and associated factors for pterygium and pinguecula in a South Indian population. ( 22112236 )
2012
11
Pinguecula and diabetes mellitus. ( 22420025 )
2012
12
Spectral domain anterior segment optical coherence tomography assessment of pterygium and pinguecula. ( 21040504 )
2012
13
Conjunctivochalasis: associations with pinguecula in a hospital-based study. ( 21518307 )
2012
14
Prevalence of pinguecula and pterygium in a general population in Spain. ( 21183945 )
2011
15
Severity and determinants of pinguecula in a hospital-based population. ( 21178698 )
2011
16
Pinguecula and contact lenses. ( 20829887 )
2010
17
Prevalence of pinguecula and pterygium in patients with thyroid orbitopathy. ( 20458231 )
2010
18
Case of argon laser photoablation of pinguecula. ( 20456434 )
2010
19
Prevalence and risk factors of pterygium and pinguecula: the Tehran Eye Study. ( 18600244 )
2009
20
Abnormal epithelial differentiation and tear film alteration in pinguecula. ( 19182253 )
2009
21
Pinguecula masquerading as conjunctival melanoma. ( 17189904 )
2007
22
Pinguecula following psoralen and ultraviolet A therapy. ( 17572286 )
2007
23
Pinguecula. ( 16928592 )
2006
24
Immunohistochemical localization of advanced glycation end products in pinguecula. ( 16034606 )
2006
25
Pterygium, pinguecula, and 5-year incidence of cataract. ( 15953456 )
2005
26
Pterygium/pinguecula and the five-year incidence of age-related maculopathy. ( 15767067 )
2005
27
Hyperexpression of low-density lipoprotein receptors and hydroxy-methylglutaryl-coenzyme A-reductase in human pinguecula and primary pterygium. ( 15505045 )
2004
28
Is age-related macular degeneration associated with pinguecula or scleral plaque formation? ( 11821983 )
2001
29
Pinguecula and SjAPgren's syndrome: two cases. ( 11403269 )
2001
30
Tear functions in patients with pinguecula. ( 11401635 )
2001
31
Presence and possible significance of immunohistochemically demonstrable metallothionein expression in pterygium versus pinguecula and normal conjunctiva. ( 11318304 )
2001
32
Relationship between pterygium/pinguecula and sunlight exposure among postmen in central Taiwan. ( 10462825 )
1999
33
p53 expression and relation to human papillomavirus infection in pingueculae, pterygia, and limbal tumors. ( 10604662 )
1999
34
Topical indomethacin solution versus dexamethasone solution for treatment of inflamed pterygium and pinguecula: a prospective randomized clinical study. ( 10030555 )
1999
35
Prevalence of pterygium and pinguecula: the Blue Mountains Eye Study. ( 9685008 )
1998
36
Cataract associations with pinguecula and pterygium: the Blue Mountains Eye Study. ( 9822237 )
1998
37
P53 expression in altered limbal basal cells of pingueculae, pterygia, and limbal tumors. ( 9426949 )
1997
38
Treatment of inflamed pterygium and pinguecula with topical indomethacin 0.1% solution. ( 8985633 )
1997
39
Etiopathology of pinguecula and pterigium. ( 8536472 )
1995
40
Pingueculae in systemic mastocytosis: a possible association. ( 1489303 )
1992
41
Elastic fiber components and protease inhibitors in pinguecula. ( 2016139 )
1991
42
The association between pinguecula, sunlight and cataract. ( 3877897 )
1985
43
Spheroid degeneration, keratopathy, pinguecula, and pterygium in Japan (Kyoto). ( 6720277 )
1984
44
The pathology of pingueculae in Gaucher's disease. ( 6544391 )
1984
45
Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula. ( 6828309 )
1983
46
Spheroid degeneration, pinguecula, and pterygium among Arabs in the Red Sea territory, Jordan. ( 7170936 )
1982
47
Pinguecula and actinic elastosis. An ultrastructural study. ( 93118 )
1979
48
Prevalence of pinguecula in Greenland and in Copenhagen, and its relation to pterygium and spheroid degeneration. ( 419982 )
1979
49
Bitot's spot overlying a pinguecula. ( 5315641 )
1971
50
The normal fine structure and aging changes of the human zonular fibers with special regard to the degeneration of collagen in senile ciliary body and in pinguecula. ( 5547521 )
1971

Variations for Pinguecula

Expression for Pinguecula

Search GEO for disease gene expression data for Pinguecula.

Pathways for Pinguecula

GO Terms for Pinguecula

Cellular components related to Pinguecula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.8 CRYAA CYP1A1 CYP2B6 CYP2E1 ITGB1 KRT10
2 organelle membrane GO:0031090 9.33 CYP1A1 CYP2B6 CYP2E1
3 intermediate filament GO:0005882 8.92 KRT10 KRT14 KRT16 KRT19

Biological processes related to Pinguecula according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.73 KRT10 KRT14 KRT16 KRT19
2 epidermis development GO:0008544 9.69 KRT14 KRT16 TP63
3 aging GO:0007568 9.67 CYP1A1 KRT14 KRT16 TP63
4 steroid metabolic process GO:0008202 9.62 CYP1A1 CYP2B6 CYP2E1 LDLR
5 cornification GO:0070268 9.56 KRT10 KRT14 KRT16 KRT19
6 establishment of skin barrier GO:0061436 9.55 KRT16 TP63
7 positive regulation of protein export from nucleus GO:0046827 9.54 TP53 XPO4
8 cellular response to low-density lipoprotein particle stimulus GO:0071404 9.52 ITGB1 LDLR
9 hair cycle GO:0042633 9.49 KRT14 KRT16
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.48 TP53 TP63
11 mitotic G1 DNA damage checkpoint GO:0031571 9.46 TP53 TP63
12 heterocycle metabolic process GO:0046483 9.4 CYP1A1 CYP2E1
13 drug metabolic process GO:0017144 9.33 CYP1A1 CYP2B6 CYP2E1
14 epoxygenase P450 pathway GO:0019373 9.13 CYP1A1 CYP2B6 CYP2E1
15 keratinocyte differentiation GO:0030216 8.92 KRT10 KRT16 PAX6 TP63

Molecular functions related to Pinguecula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.61 KRT14 KRT16 KRT19
2 protease binding GO:0002020 9.58 ITGB1 LDLR TP53
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.54 CYP1A1 CYP2B6 CYP2E1
4 monooxygenase activity GO:0004497 9.5 CYP1A1 CYP2B6 CYP2E1
5 arachidonic acid epoxygenase activity GO:0008392 9.46 CYP2B6 CYP2E1
6 oxygen binding GO:0019825 9.43 CYP1A1 CYP2B6 CYP2E1
7 steroid hydroxylase activity GO:0008395 9.33 CYP1A1 CYP2B6 CYP2E1
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.13 CYP1A1 CYP2B6 CYP2E1
9 damaged DNA binding GO:0003684 8.92 DCLRE1C TP53 TP63 XPA

Sources for Pinguecula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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