Aliases & Classifications for Pinguecula

MalaCards integrated aliases for Pinguecula:

Name: Pinguecula 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11029
ICD10 33 H11.15
ICD9CM 35 372.51
MeSH 44 D059407
NCIt 50 C129468
SNOMED-CT 68 87614000
UMLS 73 C0152255

Summaries for Pinguecula

MalaCards based summary : Pinguecula is related to basal cell carcinoma, infundibulocystic and predominantly cortical thymoma. An important gene associated with Pinguecula is KRT10 (Keratin 10), and among its related pathways/superpathways are DNA Damage and Keratinization. Affiliated tissues include eye, lung and skin, and related phenotypes are cellular and behavior/neurological

Wikipedia : 76 A pinguecula is a common type of conjunctival degeneration in the... more...

Related Diseases for Pinguecula

Diseases related to Pinguecula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma, infundibulocystic 10.2 KRT14 KRT10
2 predominantly cortical thymoma 10.2 KRT19 KRT14
3 large cell acanthoma 10.2 KRT14 KRT10
4 steatocystoma multiplex 10.2 KRT16 KRT10
5 ameloblastic carcinoma 10.2 TP63 KRT14
6 bowen's disease 10.2 KRT10 KRT16
7 palmoplantar keratoderma, epidermolytic 10.2 KRT16 KRT14 KRT10
8 intraneural perineurioma 10.2 KRT19 KRT14 KRT10
9 lipoadenoma 10.2 TP63 KRT19 KRT14
10 cataract 10.2
11 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT10 KRT14
12 squamous cell carcinoma of the oral tongue 10.1 KRT10 KRT16
13 anal gland adenocarcinoma 10.1 MUC5AC KRT19
14 white sponge nevus 1 10.1 KRT19 KRT16 KRT14 KRT10
15 primary cutaneous amyloidosis 10.1 KRT19 KRT16 KRT14 KRT10
16 anus adenocarcinoma 10.1 MUC5AC KRT19
17 gaucher's disease 10.1
18 striate palmoplantar keratoderma 10.1 KRT10 KRT14
19 cataract 24 10.1 TP53 CRYAA
20 fibroepithelial basal cell carcinoma 10.1 TP53 KRT14
21 breast squamous cell carcinoma 10.1 TP53 KRT14 KRT10
22 keratoacanthoma 10.1 TP53 KRT16 KRT10
23 mucoepidermoid carcinoma 10.1 TP63 MUC5AC KRT14
24 lichen planus 10.0 TP53 KRT16 KRT10
25 pleomorphic adenoma 10.0 TP63 TP53 KRT14
26 limbal stem cell deficiency 10.0 TP63 MUC5AC KRT19 KRT14
27 spiradenoma 10.0 KRT14 TP53
28 phacolytic glaucoma 10.0 CRYAA CD68
29 papilloma 10.0 TP63 TP53 KRT14 KRT10
30 liver angiosarcoma 10.0 TP53 KRT19 CYP2E1
31 pregnancy adenoma 10.0 KRT19 KRT14 CD68
32 arcus corneae 9.9
33 aging 9.9
34 macular degeneration, age-related, 1 9.9
35 diabetes mellitus 9.9
36 keratopathy 9.9
37 systemic mastocytosis 9.9
38 melanoma 9.9
39 mastocytosis 9.9
40 conjunctivochalasis 9.9
41 conjunctivitis 9.9
42 ligneous conjunctivitis 9.9
43 adenoid cystic carcinoma 9.9 TP63 TP53 KRT19 KRT14
44 hidradenocarcinoma 9.9 TP63 TP53 MUC5AC
45 biliary papillomatosis 9.9 TP53 MUC5AC KRT19
46 bile duct adenocarcinoma 9.9 TP53 MUC5AC KRT19
47 oral cancer 9.9 TP53 KRT19 CYP1A1
48 intrahepatic cholangiocarcinoma 9.9 TP53 MUC5AC KRT19
49 anal canal adenocarcinoma 9.9 KRT19 MUC5AC
50 lung squamous cell carcinoma 9.8 TP63 TP53 KRT19 CYP1A1

Graphical network of the top 20 diseases related to Pinguecula:



Diseases related to Pinguecula

Symptoms & Phenotypes for Pinguecula

MGI Mouse Phenotypes related to Pinguecula:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 DCLRE1C ITGB1 KRT14 KRT16 KRT19 LDLR
2 behavior/neurological MP:0005386 10.26 CYP2E1 ITGB1 KRT16 LDLR MUC5AC PAX6
3 growth/size/body region MP:0005378 10.26 CYP1A1 DCLRE1C ITGB1 KRT14 KRT16 KRT19
4 cardiovascular system MP:0005385 10.25 CYP1A1 CYP2E1 DCLRE1C ITGB1 KRT19 LDLR
5 endocrine/exocrine gland MP:0005379 10.24 CYP1A1 DCLRE1C ITGB1 KRT14 KRT19 LDLR
6 homeostasis/metabolism MP:0005376 10.23 CYP1A1 CYP2E1 ITGB1 KRT14 KRT16 LDLR
7 immune system MP:0005387 10.21 CD68 CYP1A1 DCLRE1C ITGB1 KRT14 LDLR
8 digestive/alimentary MP:0005381 10.16 ITGB1 KRT14 KRT16 KRT19 LDLR MUC5AC
9 mortality/aging MP:0010768 10.15 CYP1A1 CYP2E1 ITGB1 KRT14 KRT16 KRT19
10 craniofacial MP:0005382 10.07 ITGB1 KRT14 KRT16 PAX6 TP53 TP63
11 integument MP:0010771 10.06 ITGB1 KRT14 KRT16 KRT19 LDLR PAX6
12 neoplasm MP:0002006 9.97 CYP2E1 ITGB1 KRT14 KRT19 PAX6 TGM2
13 no phenotypic analysis MP:0003012 9.8 CD68 CYP1A1 KRT19 LDLR TGM2 TP53
14 normal MP:0002873 9.76 CYP1A1 ITGB1 KRT19 LDLR PAX6 TP53
15 pigmentation MP:0001186 9.43 ITGB1 KRT14 LDLR PAX6 TP53 XPA
16 vision/eye MP:0005391 9.23 ITGB1 KRT14 LDLR MUC5AC PAX6 TP53

Drugs & Therapeutics for Pinguecula

Search Clinical Trials , NIH Clinical Center for Pinguecula

Cochrane evidence based reviews: pinguecula

Genetic Tests for Pinguecula

Anatomical Context for Pinguecula

MalaCards organs/tissues related to Pinguecula:

41
Eye, Lung, Skin, Liver, Tongue, Tonsil, Pancreas

Publications for Pinguecula

Articles related to Pinguecula:

(show top 50) (show all 53)
# Title Authors Year
1
Corneal Epithelial Damage and Impaired Tear Functions in Patients with Inflamed Pinguecula. ( 30515317 )
2018
2
Resolution of pinguecula-related dry eye disease after argon laser photocoagulation. ( 28769593 )
2017
3
Vascular Regression After Pinguecula Excision and Conjunctival Autograft Using Fibrin Glue. ( 27058827 )
2016
4
Prevalence and associated factors of pinguecula in a rural population in shanghai, eastern china. ( 25777313 )
2015
5
Significance of Fuchs Flecks in Patients With Pterygium/Pinguecula: Earliest Indicator of Ultraviolet Light Damage. ( 26398157 )
2015
6
Relationship between pinguecula formation and exposure to tandoor ovens in a hospital-based study. ( 25540757 )
2014
7
Unusual large uniocular elastoid and collagenous pinguecula. ( 24807233 )
2014
8
Intra-lesional injection of betamethasone for the treatment of symptomatic pinguecula. ( 24269437 )
2013
9
One-year outcome of argon laser photocoagulation of pinguecula. ( 23449487 )
2013
10
The prevalence and determinants of pterygium and pinguecula in an urban population in Shahroud, Iran. ( 23275285 )
2012
11
Prevalence and associated factors for pterygium and pinguecula in a South Indian population. ( 22112236 )
2012
12
Pinguecula and diabetes mellitus. ( 22420025 )
2012
13
Spectral domain anterior segment optical coherence tomography assessment of pterygium and pinguecula. ( 21040504 )
2012
14
Conjunctivochalasis: associations with pinguecula in a hospital-based study. ( 21518307 )
2012
15
Prevalence of pinguecula and pterygium in a general population in Spain. ( 21183945 )
2011
16
Severity and determinants of pinguecula in a hospital-based population. ( 21178698 )
2011
17
Pinguecula and contact lenses. ( 20829887 )
2010
18
Prevalence of pinguecula and pterygium in patients with thyroid orbitopathy. ( 20458231 )
2010
19
Case of argon laser photoablation of pinguecula. ( 20456434 )
2010
20
Prevalence and risk factors of pterygium and pinguecula: the Tehran Eye Study. ( 18600244 )
2009
21
Abnormal epithelial differentiation and tear film alteration in pinguecula. ( 19182253 )
2009
22
Pinguecula masquerading as conjunctival melanoma. ( 17189904 )
2007
23
Pinguecula following psoralen and ultraviolet A therapy. ( 17572286 )
2007
24
Pinguecula. ( 16928592 )
2006
25
Immunohistochemical localization of advanced glycation end products in pinguecula. ( 16034606 )
2006
26
Pterygium, pinguecula, and 5-year incidence of cataract. ( 15953456 )
2005
27
Pterygium/pinguecula and the five-year incidence of age-related maculopathy. ( 15767067 )
2005
28
Hyperexpression of low-density lipoprotein receptors and hydroxy-methylglutaryl-coenzyme A-reductase in human pinguecula and primary pterygium. ( 15505045 )
2004
29
Is age-related macular degeneration associated with pinguecula or scleral plaque formation? ( 11821983 )
2001
30
Pinguecula and SjAPgren's syndrome: two cases. ( 11403269 )
2001
31
Tear functions in patients with pinguecula. ( 11401635 )
2001
32
Presence and possible significance of immunohistochemically demonstrable metallothionein expression in pterygium versus pinguecula and normal conjunctiva. ( 11318304 )
2001
33
Relationship between pterygium/pinguecula and sunlight exposure among postmen in central Taiwan. ( 10462825 )
1999
34
Topical indomethacin solution versus dexamethasone solution for treatment of inflamed pterygium and pinguecula: a prospective randomized clinical study. ( 10030555 )
1999
35
Prevalence of pterygium and pinguecula: the Blue Mountains Eye Study. ( 9685008 )
1998
36
Cataract associations with pinguecula and pterygium: the Blue Mountains Eye Study. ( 9822237 )
1998
37
Treatment of inflamed pterygium and pinguecula with topical indomethacin 0.1% solution. ( 8985633 )
1997
38
Etiopathology of pinguecula and pterigium. ( 8536472 )
1995
39
Elastic fiber components and protease inhibitors in pinguecula. ( 2016139 )
1991
40
Long-term changes in the outer part of the eye in welders. Prevalence of spheroid degeneration, pinguecula, pterygium, and corneal cicatrices. ( 1927324 )
1991
41
The association between pinguecula, sunlight and cataract. ( 3877897 )
1985
42
Spheroid degeneration, keratopathy, pinguecula, and pterygium in Japan (Kyoto). ( 6720277 )
1984
43
Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula. ( 6828309 )
1983
44
Spheroid degeneration, pinguecula, and pterygium among Arabs in the Red Sea territory, Jordan. ( 7170936 )
1982
45
Pinguecula and actinic elastosis. An ultrastructural study. ( 93118 )
1979
46
Prevalence of pinguecula in Greenland and in Copenhagen, and its relation to pterygium and spheroid degeneration. ( 419982 )
1979
47
Pinguecula and pterygium (a histopathological study). ( 1031388 )
1976
48
Bitot's spot overlying a pinguecula. ( 5315641 )
1971
49
The normal fine structure and aging changes of the human zonular fibers with special regard to the degeneration of collagen in senile ciliary body and in pinguecula. ( 5547521 )
1971
50
Pterygium and pinguecula: electron microscopic study. ( 4143711 )
1967

Variations for Pinguecula

Expression for Pinguecula

Search GEO for disease gene expression data for Pinguecula.

Pathways for Pinguecula

GO Terms for Pinguecula

Cellular components related to Pinguecula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.8 CRYAA CYP1A1 CYP2B6 CYP2E1 ITGB1 KRT10
2 organelle membrane GO:0031090 9.33 CYP1A1 CYP2B6 CYP2E1
3 intermediate filament GO:0005882 8.92 KRT10 KRT14 KRT16 KRT19

Biological processes related to Pinguecula according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.73 KRT10 KRT14 KRT16 KRT19
2 aging GO:0007568 9.67 CYP1A1 KRT14 KRT16 TP63
3 epidermis development GO:0008544 9.63 KRT14 KRT16 TP63
4 steroid metabolic process GO:0008202 9.62 CYP1A1 CYP2B6 CYP2E1 LDLR
5 cornification GO:0070268 9.56 KRT10 KRT14 KRT16 KRT19
6 cellular response to low-density lipoprotein particle stimulus GO:0071404 9.54 ITGB1 LDLR
7 establishment of skin barrier GO:0061436 9.52 KRT16 TP63
8 hair cycle GO:0042633 9.51 KRT14 KRT16
9 positive regulation of protein export from nucleus GO:0046827 9.49 TP53 XPO4
10 developmental process GO:0032502 9.48 CYP1A1 TP63
11 heterocycle metabolic process GO:0046483 9.4 CYP1A1 CYP2E1
12 drug metabolic process GO:0017144 9.33 CYP1A1 CYP2B6 CYP2E1
13 epoxygenase P450 pathway GO:0019373 9.13 CYP1A1 CYP2B6 CYP2E1
14 keratinocyte differentiation GO:0030216 8.92 KRT10 KRT16 PAX6 TP63

Molecular functions related to Pinguecula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.58 KRT14 KRT16 KRT19
2 protease binding GO:0002020 9.54 ITGB1 LDLR TP53
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.5 CYP1A1 CYP2B6 CYP2E1
4 arachidonic acid epoxygenase activity GO:0008392 9.43 CYP2B6 CYP2E1
5 damaged DNA binding GO:0003684 9.43 DCLRE1C TP63 XPA
6 monooxygenase activity GO:0004497 9.33 CYP1A1 CYP2B6 CYP2E1
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.13 CYP1A1 CYP2B6 CYP2E1
8 steroid hydroxylase activity GO:0008395 8.8 CYP1A1 CYP2B6 CYP2E1

Sources for Pinguecula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....