MCID: PNG001
MIFTS: 31

Pinguecula

Categories: Neuronal diseases

Aliases & Classifications for Pinguecula

MalaCards integrated aliases for Pinguecula:

Name: Pinguecula 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11029
ICD9CM 34 372.51
MeSH 44 D059407
NCIt 50 C129468
SNOMED-CT 67 267735001
ICD10 32 H11.15
UMLS 70 C0152255

Summaries for Pinguecula

MalaCards based summary : Pinguecula is related to pseudopterygium and skin carcinoma. An important gene associated with Pinguecula is KRT10 (Keratin 10), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. Affiliated tissues include eye, kidney and thyroid, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 73 A pinguecula is a common type of conjunctival stromal degeneration in the eye. It appear as an elevated... more...

Related Diseases for Pinguecula

Diseases related to Pinguecula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 pseudopterygium 29.5 PAX6 KRT19 IFNA2
2 skin carcinoma 29.3 KRT19 KRT14 KRT10 IFNA2
3 double pterygium 10.9
4 central pterygium 10.9
5 progressive peripheral pterygium 10.9
6 bowen's disease 10.3 KRT16 KRT10
7 large cell acanthoma 10.3 KRT14 KRT10
8 striate palmoplantar keratoderma 10.3 KRT14 KRT10
9 pulmonary artery leiomyosarcoma 10.3 KRT19 KRT10
10 eccrine acrospiroma 10.3 KRT19 KRT10
11 pericardial mesothelioma 10.3 KRT19 KRT10
12 mucinous tubular and spindle renal cell carcinoma 10.2 KRT19 KRT10
13 squamous cell bile duct carcinoma 10.2 KRT19 KRT14
14 odontoma 10.2 KRT19 KRT14
15 hair follicle neoplasm 10.2 KRT14 KRT10
16 steatocystoma multiplex 10.2 KRT16 KRT10
17 clear cell basal cell carcinoma 10.2 KRT19 KRT14
18 ameloblastic carcinoma 10.2 TP63 KRT14
19 pancreatoblastoma 10.2 KRT14 KRT10
20 benign peritoneal mesothelioma 10.2 KRT19 KRT14
21 skin papilloma 10.2 KRT14 KRT10
22 cystic basal cell carcinoma 10.2 TP63 KRT14
23 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT14 KRT10
24 intraductal papilloma 10.2 TP63 KRT14
25 epidermolysis bullosa simplex, dowling-meara type 10.2 KRT14 KRT10
26 epidermolysis bullosa 10.1 KRT16 KRT14 KRT10
27 borst-jadassohn intraepidermal carcinoma 10.1 KRT16 KRT14 KRT10
28 palmoplantar keratoderma, epidermolytic 10.1 KRT16 KRT14 KRT10
29 keratoacanthoma 10.1 KRT16 KRT14 KRT10
30 pachyonychia congenita 1 10.1 KRT16 KRT14 KRT10
31 keratosis 10.1 KRT16 KRT14 KRT10
32 cholesteatoma of middle ear 10.1 KRT16 KRT14 KRT10
33 eccrine papillary adenocarcinoma 10.1 KRT19 KRT14 KRT10
34 eccrine sweat gland neoplasm 10.1 KRT19 KRT14 KRT10
35 epidermolytic hyperkeratosis 10.1 KRT16 KRT14 KRT10
36 trachoma 10.1
37 keratopathy 10.1
38 cataract 10.1
39 hidradenitis 10.1 KRT14 KRT10
40 lipoadenoma 10.1 TP63 KRT19 KRT14
41 limbal stem cell deficiency 10.1 TP63 KRT19 KRT14
42 palmoplantar keratoderma, nonepidermolytic 10.1 KRT16 JUP
43 sjogren-larsson syndrome 10.1 KRT14 ALDH3A1
44 basaloid squamous cell carcinoma 10.1 TP63 KRT19 KRT14
45 myoepithelioma 10.1 TP63 KRT14
46 hyaline fibromatosis syndrome 10.1 KRT14 KRT10
47 mucoepidermoid carcinoma 10.0 TP63 KRT19 KRT14
48 papilloma 10.0 TP63 KRT14 KRT10
49 autosomal recessive congenital ichthyosis 10.0 KRT16 KRT14 KRT10
50 breast ductal carcinoma 10.0 TP63 KRT19 KRT14

Graphical network of the top 20 diseases related to Pinguecula:



Diseases related to Pinguecula

Symptoms & Phenotypes for Pinguecula

MGI Mouse Phenotypes related to Pinguecula:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.81 ALDH3A1 JUP KRT14 KRT16 KRT19 LDLR
2 craniofacial MP:0005382 9.8 JUP KRT14 KRT16 KRT19 PAX6 TP63
3 digestive/alimentary MP:0005381 9.73 KRT14 KRT16 KRT19 LDLR PAX6 TP63
4 integument MP:0010771 9.5 JUP KRT14 KRT16 KRT19 LDLR PAX6
5 normal MP:0002873 9.17 ALDH3A1 JUP KRT19 LDLR PAX6 PKP4

Drugs & Therapeutics for Pinguecula

Search Clinical Trials , NIH Clinical Center for Pinguecula

Cochrane evidence based reviews: pinguecula

Genetic Tests for Pinguecula

Anatomical Context for Pinguecula

MalaCards organs/tissues related to Pinguecula:

40
Eye, Kidney, Thyroid

Publications for Pinguecula

Articles related to Pinguecula:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Conjunctival Actinic Granuloma: A Clinicopathological and Immunohistochemical Study With a Review of the Literature and a Differential Diagnosis. 61
33587421 2021
2
Protection of the Eye from Ultraviolet Radiation Damage Among Adults in Addis Zemen Town, Northwest Ethiopia. 61
33519252 2021
3
Pinguecula with spheroidal degeneration: clinicopathologic correlation. 61
33356725 2020
4
Pinguecula Nonresponsive to Green (532 nm) Laser Photocoagulation. 61
32131121 2020
5
Accuracy of diagnosis of pterygium by optometrists and general practitioners in Australia. 61
31060100 2020
6
Optical Coherence Tomography Angiography in Pinguecula and Pterygium. 61
31436638 2020
7
[Prevalence of ophthalmic diseases in the population older than 50 years]. 61
32504485 2020
8
Repeatability of ocular surface vessel density measurements with optical coherence tomography angiography. 61
31823755 2019
9
Clinical Features of Pingueculitis Revealed by Anterior Segment Optical Coherence Tomography Findings. 61
31663916 2019
10
Relationship Between Contact Lens and Pinguecula. 61
30801268 2019
11
The Improvement of Dry Eye Symptoms after Pinguecula Excision and Conjunctival Autograft with Fibrin Glue. 61
31281668 2019
12
Conjunctivochalasis and Related Factors in an Adult Population of Iran. 61
28346280 2018
13
A Case of Allergic Urticaria After Ophthalmic Nepafenac Use. 61
29988879 2018
14
Prevalence of ocular findings in a sample of Egyptian patients with psoriasis. 61
29067934 2018
15
Corneal Epithelial Damage and Impaired Tear Functions in Patients with Inflamed Pinguecula. 61
30515317 2018
16
Ophthalmic Findings in Patients After Renal Transplantation. 61
28838433 2017
17
Meibomian gland dysfunction and its determinants in Iranian adults: A population-based study. 61
28501443 2017
18
Risk Factors for Pterygium in Ilam Province, Iran. 61
28791059 2017
19
Vascular Regression After Pinguecula Excision and Conjunctival Autograft Using Fibrin Glue. 61
27058827 2017
20
Morphometric characterisation of pterygium associated with corneal stromal scarring using high-resolution anterior segment optical coherence tomography. 61
27488179 2017
21
Resolution of pinguecula-related dry eye disease after argon laser photocoagulation. 61
28769593 2017
22
Prevalence of Ocular Anomalies among Schoolchildren in Ashaiman, Ghana. 61
26905691 2016
23
Conjunctival metastatic adenocarcinoma of unknown origin. 61
27190113 2016
24
Significance of Fuchs Flecks in Patients With Pterygium/Pinguecula: Earliest Indicator of Ultraviolet Light Damage. 61
26398157 2015
25
High-Resolution Optical Coherence Tomography as an Adjunctive Tool in the Diagnosis of Corneal and Conjunctival Pathology. 61
26045235 2015
26
Prevalence and associated factors of pinguecula in a rural population in Shanghai, Eastern China. 61
25777313 2015
27
Handheld reflectance confocal microscopy for the diagnosis of conjunctival tumors. 61
25447117 2015
28
[Ophthalmology and urban underprivileged. Experience of 150 patients]. 61
25577432 2015
29
Clinical applications of anterior segment optical coherence tomography. 61
25821589 2015
30
[Intra-lesional injection of betamethasone for the treatment of symptomatic pinguecula]. 61
24269437 2014
31
Limitations in imaging common conjunctival and corneal pathologies with fourier-domain optical coherence tomography. 61
25100905 2014
32
Unusual large uniocular elastoid and collagenous pinguecula. 61
24807233 2014
33
Ultraviolet light and ocular diseases. 61
23722672 2014
34
Allergic conjunctivitis in Jos-Nigeria. 61
24791053 2014
35
Relationship between pinguecula formation and exposure to tandoor ovens in a hospital-based study. 61
25540757 2014
36
Clinical characteristics of patients with conjunctivochalasis. 61
25210435 2014
37
The pathologic characteristics of pingueculae on autofluorescence images. 61
24311926 2013
38
Cosmetic regional conjunctivectomy with postoperative mitomycin C application with or without bevacizumab injection. 61
23570698 2013
39
One-year outcome of argon laser photocoagulation of pinguecula. 61
23449487 2013
40
Conjunctivochalasis: associations with pinguecula in a hospital-based study. 61
21518307 2012
41
Prevalence and associations of external punctal stenosis in a general population in Spain. 61
22367046 2012
42
Prevalence and risk factors of meibomian gland dysfunction: the Singapore Malay eye study. 61
22236788 2012
43
Spectral domain anterior segment optical coherence tomography assessment of pterygium and pinguecula. 61
21040504 2012
44
Evaluation of dry eye signs and symptoms in patients with systemic sclerosis. 61
22349977 2012
45
[Ocular conjunctival pathology. A ten-year retrospective study in Toulouse-Rangueil University Hospital and literature review]. 61
22748330 2012
46
Intraocular extension of conjunctival invasive squamous cell carcinoma after pterygium surgery and cataract extraction. 61
22169876 2012
47
Pinguecula and diabetes mellitus. 61
22420025 2012
48
Repeated applications of impression cytology to increase sensitivity for diagnosis of conjunctival intraepithelial neoplasia. 61
21498806 2012
49
Prevalence and associated factors for pterygium and pinguecula in a South Indian population. 61
22112236 2012
50
[Chronic inflammatory and dystrophic diseases of the eye anterior segment and their association with genetic polymorphisms in workers of metallurgic industry]. 61
22997752 2012

Variations for Pinguecula

Expression for Pinguecula

Search GEO for disease gene expression data for Pinguecula.

Pathways for Pinguecula

GO Terms for Pinguecula

Cellular components related to Pinguecula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adherens junction GO:0005912 9.43 ARVCF JUP PKP4
2 desmosome GO:0030057 9.32 PKP4 JUP
3 apicolateral plasma membrane GO:0016327 9.16 JUP KRT19
4 cornified envelope GO:0001533 9.13 PKP4 KRT10 JUP
5 intermediate filament GO:0005882 9.02 JUP KRT10 KRT14 KRT16 KRT19

Biological processes related to Pinguecula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 9.58 PKP4 JUP ARVCF
2 aging GO:0007568 9.56 ALDH3A1 KRT14 KRT16 TP63
3 keratinocyte differentiation GO:0030216 9.46 KRT10 KRT16 PAX6 TP63
4 cell-cell junction assembly GO:0007043 9.43 ARVCF PKP4
5 keratinization GO:0031424 9.43 JUP KRT10 KRT14 KRT16 KRT19 PKP4
6 establishment of skin barrier GO:0061436 9.37 KRT16 TP63
7 hair cycle GO:0042633 9.32 KRT14 KRT16
8 cornification GO:0070268 9.1 PKP4 KRT19 KRT16 KRT14 KRT10 JUP

Molecular functions related to Pinguecula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 KRT19 KRT16 KRT14
2 structural molecule activity GO:0005198 9.02 JUP KRT10 KRT14 KRT16 KRT19

Sources for Pinguecula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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