PITA1
MCID: PTT056
MIFTS: 44

Pituitary Adenoma 1, Multiple Types (PITA1)

Categories: Genetic diseases, Endocrine diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Pituitary Adenoma 1, Multiple Types

MalaCards integrated aliases for Pituitary Adenoma 1, Multiple Types:

Name: Pituitary Adenoma 1, Multiple Types 57 75
Acromegaly Due to Pituitary Adenoma 1 57 75
Isolated Familial Somatotropinoma 57 75
Somatotrophinoma, Familial 57 73
Pituitary Gigantism 59 37
Pita1 57 75
Pagh1 57 75
Fis 57 75
Ifs 57 75
Adenoma, Pituitary, Growth Hormone-Secreting, Type 1 40
Pituitary Adenoma, Growth Hormone-Secreting, 1 75
Infantile and Juvenile Forms of Acromegaly 59
Somatotropinoma, Familial Isolated; Fis 57
Isolated Familial Somatotropinoma; Ifs 57
Pituitary Adenoma, Familial Isolated 73
Familial Isolated Pituitary Adenoma 75
Acromegaly Due to Pituitary Adenoma 75
Somatotropinoma, Familial Isolated 57
Multiple Gastrointestinal Atresias 73
Familial Isolated Somatotropinomas 75
Pituitary Adenoma Predisposition 73
Familial Somatotrophinoma 75
Hypophyseal Gigantism 59
Gigantism Pituitary 55
Gigantism 73
Fipa 75

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant
somatic mutation

Miscellaneous:
onset in second or third decades


HPO:

32
pituitary adenoma 1, multiple types:
Inheritance somatic mutation autosomal dominant inheritance


Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Pituitary Adenoma 1, Multiple Types

OMIM : 57 Mutations in the AIP gene have been found predominantly in growth hormone (GH)-secreting adenomas, but have also been found in adrenocorticotropic hormone (ACTH)-secreting, thyroid hormone (TSH)-secreting, and prolactin (PRL)-secreting pituitary tumors. Pituitary adenomas are benign monoclonal neoplasms of the anterior pituitary gland, accounting for approximately 15% of intracranial tumors. Growth hormone (139250)-secreting adenomas, also known as somatotropinomas, which clinically result in acromegaly, comprise about 20% of all pituitary tumors and are the second most common hormone-secreting pituitary tumor after prolactin (176760)-secreting tumors, which account for 40 to 45% of pituitary tumors. ACTH-secreting tumors, which result in Cushing disease, and thyrotropin (TSHB; 188540)-secreting tumors are much less common. Nonsecreting pituitary tumors, which account for about 33%, can cause symptoms due to local compressive effects of tumor growth (Vierimaa et al., 2006; Georgitsi et al., 2007; Horvath and Stratakis, 2008). Acromegaly is characterized by coarse facial features, protruding jaw, and enlarged extremities (Vierimaa et al., 2006). Familial isolated somatotropinoma (FIS) is defined as the occurrence of at least 2 cases of acromegaly or gigantism in a family that does not exhibit features of other endocrine syndromes. FIS patients tend to have onset about 4 to 10 years earlier than patients with sporadic disease (Gadelha et al., 1999; Horvath and Stratakis, 2008). Cushing disease is characterized by central obesity, moon facies, diabetes, 'buffalo hump,' hypertension, fatigue, easy bruising, depression, and reproductive disorders. Cushing disease is associated with increased morbidity and mortality, mainly due to cardiovascular or cerebrovascular disease and infections (summary by Perez-Rivas et al., 2015). Familial isolated pituitary adenoma (FIPA) and pituitary adenoma predisposition (PAP) are terms referring to families in which 2 or more individuals develop pituitary tumors. Within a family, tumor types can be heterogeneous, with members of the same family having GH-secreting, prolactin-secreting, ACTH-secreting, or nonsecreting adenomas; in contrast, some families are homogeneous with regard to tumor type. Familial isolated somatotropinoma refers specifically to GH-secreting tumors and is usually associated with an acromegaly phenotype. Thus, FIS is a subset of FIPA or PAP (Toledo et al., 2007). Schlechte (2003) discussed prolactinoma in general terms as a clinical, diagnostic, and therapeutic problem. (102200)

MalaCards based summary : Pituitary Adenoma 1, Multiple Types, also known as acromegaly due to pituitary adenoma 1, is related to mccune-albright syndrome and gigantism, and has symptoms including endocrine system signs and symptoms An important gene associated with Pituitary Adenoma 1, Multiple Types is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and ErbB4 Pathway. Affiliated tissues include pituitary and thyroid, and related phenotypes are frontal bossing and hyperhidrosis

UniProtKB/Swiss-Prot : 75 Pituitary adenoma 1, multiple types: A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported.

Related Diseases for Pituitary Adenoma 1, Multiple Types

Diseases in the Pituitary Adenoma family:

Pituitary Adenoma 1, Multiple Types Pituitary Adenoma 5, Multiple Types
Pituitary Adenoma 3, Multiple Types

Diseases related to Pituitary Adenoma 1, Multiple Types via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 mccune-albright syndrome 30.6 GH1 IGF1 PRL SST
2 gigantism 30.5 AIP GH1 PRL
3 hyperthyroidism 30.5 GH1 PRL SST
4 pituitary adenoma, prolactin-secreting 29.8 AIP GH1 IGF1 PRL SST
5 turner syndrome 28.7 GH1 IGF1 IGFBP3
6 insulin-like growth factor i 27.8 GH1 IGF1 IGFBP3 PRL
7 acromegaly 27.4 AIP GH1 IGF1 IGFBP3 PRL SST
8 familial isolated pituitary adenoma 12.6
9 aip-related familial isolated pituitary adenomas 12.4
10 congenital disorder of glycosylation, type if 12.3
11 amelogenesis imperfecta, type if 12.3
12 neuropathy, hereditary sensory, type if 12.3
13 usher syndrome, type if 12.1
14 pituitary adenoma 2, growth hormone-secreting 11.5
15 fecal incontinence 11.4
16 chronic kidney failure 11.0
17 vaginitis 11.0
18 pituitary adenoma 5, multiple types 10.9
19 pituitary adenoma 3, multiple types 10.9
20 hepatitis b 10.9
21 endocarditis 10.9
22 sickle cell disease 10.9
23 charcot-marie-tooth disease, demyelinating, type 1f 10.9
24 prostate cancer 10.9
25 headache 10.9
26 malaria 10.9
27 constipation 10.9
28 syphilis 10.9
29 pulmonary embolism 10.9
30 fainting 10.9
31 aneurysm 10.9
32 pulmonary fibrosis, idiopathic 10.9
33 cystic fibrosis 10.9
34 alpha-1-antitrypsin deficiency 10.9
35 atrial fibrillation 10.9
36 fibromyalgia 10.9
37 varicose veins 10.8
38 sinusitis 10.8
39 gout 10.8
40 aortic aneurysm 10.8
41 gastroesophageal reflux 10.8
42 obsessive-compulsive disorder 10.8
43 biotinidase deficiency 10.8
44 diabetes mellitus 10.8
45 rickets 10.8
46 hellp syndrome 10.8
47 pneumonia 10.8
48 chronic fatigue syndrome 10.8
49 learning disability 10.8
50 lymphoma 10.8

Graphical network of the top 20 diseases related to Pituitary Adenoma 1, Multiple Types:



Diseases related to Pituitary Adenoma 1, Multiple Types

Symptoms & Phenotypes for Pituitary Adenoma 1, Multiple Types

Symptoms via clinical synopsis from OMIM:

57
Cardiovascular Vascular:
hypertension

Cardiovascular Heart:
cardiomyopathy
left ventricular hypertrophy

Endocrine Features:
menstrual irregularities
acromegaly
cushing disease due to increased acth secretion (less common)

Chest Breasts:
galactorrhea from increased serum prolactin

Skeletal Feet:
enlarged feet

Laboratory Abnormalities:
increased serum growth hormone levels
increased serum igf1
increased serum prolactin

Head And Neck Face:
coarse facial features
mandibular enlargement

Neoplasia:
pituitary adenoma
somatotrophinoma
prolactinoma

Growth Height:
increased height

Skeletal Hands:
enlarged hands

Neurologic Central Nervous System:
anterior pituitary adenoma


Clinical features from OMIM:

102200

Human phenotypes related to Pituitary Adenoma 1, Multiple Types:

59 32 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 frontal bossing 59 32 hallmark (90%) Very frequent (99-80%) HP:0002007
2 hyperhidrosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000975
3 coarse facial features 59 32 hallmark (90%) Very frequent (99-80%) HP:0000280
4 mandibular prognathia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000303
5 type ii diabetes mellitus 59 32 hallmark (90%) Very frequent (99-80%) HP:0005978
6 hypertrophic cardiomyopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0001639
7 left ventricular hypertrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0001712
8 growth hormone excess 59 32 hallmark (90%) Very frequent (99-80%) HP:0000845
9 pituitary prolactin cell adenoma 59 32 frequent (33%) Frequent (79-30%) HP:0006767
10 pituitary growth hormone cell adenoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0011760
11 large hands 59 32 hallmark (90%) Very frequent (99-80%) HP:0001176
12 accelerated skeletal maturation 59 32 hallmark (90%) Very frequent (99-80%) HP:0005616
13 galactorrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0100829
14 prolactin excess 59 32 frequent (33%) Frequent (79-30%) HP:0000870
15 amenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000141
16 long foot 59 32 hallmark (90%) Very frequent (99-80%) HP:0001833
17 proportionate tall stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0011407
18 premature pubarche 59 32 hallmark (90%) Very frequent (99-80%) HP:0012411
19 increased serum insulin-like growth factor 1 59 32 hallmark (90%) Very frequent (99-80%) HP:0030269
20 hypertension 32 HP:0000822
21 cardiomyopathy 32 HP:0001638
22 pituitary adenoma 32 HP:0002893
23 tall stature 59 Very frequent (99-80%)
24 menstrual irregularities 32 HP:0000858
25 prolactinoma 32 HP:0040278

UMLS symptoms related to Pituitary Adenoma 1, Multiple Types:


endocrine system signs and symptoms

Drugs & Therapeutics for Pituitary Adenoma 1, Multiple Types

Search Clinical Trials , NIH Clinical Center for Pituitary Adenoma 1, Multiple Types

Genetic Tests for Pituitary Adenoma 1, Multiple Types

Anatomical Context for Pituitary Adenoma 1, Multiple Types

MalaCards organs/tissues related to Pituitary Adenoma 1, Multiple Types:

41
Pituitary, Thyroid

Publications for Pituitary Adenoma 1, Multiple Types

Articles related to Pituitary Adenoma 1, Multiple Types:

# Title Authors Year
1
Isolated familial somatotropinoma: 11q13-loh and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis. ( 20454499 )
2010
2
Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma. ( 19443539 )
2009
3
A meiotic recombination in a new isolated familial somatotropinoma kindred. ( 15132719 )
2004
4
Isolated familial somatotropinoma. ( 15761658 )
2004
5
Isolated familial somatotropinomas: clinical and genetic considerations. ( 12813918 )
2003
6
Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12. ( 10690880 )
2000

Variations for Pituitary Adenoma 1, Multiple Types

UniProtKB/Swiss-Prot genetic disease variations for Pituitary Adenoma 1, Multiple Types:

75
# Symbol AA change Variation ID SNP ID
1 AIP p.Arg304Gln VAR_043913

ClinVar genetic disease variations for Pituitary Adenoma 1, Multiple Types:

6
(show top 50) (show all 104)
# Gene Variation Type Significance SNP ID Assembly Location
1 AIP NM_003977.3(AIP): c.40C> T (p.Gln14Ter) single nucleotide variant Pathogenic rs104894194 GRCh37 Chromosome 11, 67250669: 67250669
2 AIP NM_003977.3(AIP): c.40C> T (p.Gln14Ter) single nucleotide variant Pathogenic rs104894194 GRCh38 Chromosome 11, 67483198: 67483198
3 AIP NM_003977.3(AIP): c.469-1G> A single nucleotide variant Pathogenic/Likely pathogenic rs267606555 GRCh37 Chromosome 11, 67257508: 67257508
4 AIP NM_003977.3(AIP): c.469-1G> A single nucleotide variant Pathogenic/Likely pathogenic rs267606555 GRCh38 Chromosome 11, 67490037: 67490037
5 AIP NM_003977.3(AIP): c.910C> T (p.Arg304Ter) single nucleotide variant Pathogenic rs104894195 GRCh37 Chromosome 11, 67258381: 67258381
6 AIP NM_003977.3(AIP): c.910C> T (p.Arg304Ter) single nucleotide variant Pathogenic rs104894195 GRCh38 Chromosome 11, 67490910: 67490910
7 AIP NM_003977.3(AIP): c.66_71delAGGAGA (p.Gly23_Glu24del) deletion Pathogenic/Likely pathogenic rs267606567 GRCh37 Chromosome 11, 67250695: 67250700
8 AIP NM_003977.3(AIP): c.66_71delAGGAGA (p.Gly23_Glu24del) deletion Pathogenic/Likely pathogenic rs267606567 GRCh38 Chromosome 11, 67483224: 67483229
9 AIP NM_003977.3(AIP): c.824dupA (p.His275Glnfs) duplication Pathogenic/Likely pathogenic rs267606580 GRCh37 Chromosome 11, 67258295: 67258295
10 AIP NM_003977.3(AIP): c.824dupA (p.His275Glnfs) duplication Pathogenic/Likely pathogenic rs267606580 GRCh38 Chromosome 11, 67490824: 67490824
11 AIP NM_003977.3(AIP): c.542delT (p.Ile182Serfs) deletion Pathogenic/Likely pathogenic rs267606559 GRCh37 Chromosome 11, 67257582: 67257582
12 AIP NM_003977.3(AIP): c.542delT (p.Ile182Serfs) deletion Pathogenic/Likely pathogenic rs267606559 GRCh38 Chromosome 11, 67490111: 67490111
13 AIP NM_003977.3(AIP): c.804C> A (p.Tyr268Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121908356 GRCh37 Chromosome 11, 67258275: 67258275
14 AIP NM_003977.3(AIP): c.804C> A (p.Tyr268Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121908356 GRCh38 Chromosome 11, 67490804: 67490804
15 AIP NM_003977.3(AIP): c.64C> T (p.Arg22Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121908357 GRCh37 Chromosome 11, 67250693: 67250693
16 AIP NM_003977.3(AIP): c.64C> T (p.Arg22Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121908357 GRCh38 Chromosome 11, 67483222: 67483222
17 AIP NM_003977.2(AIP): c.-1212_279+578del deletion Likely pathogenic GRCh37 Chromosome 11, 67249418: 67255234
18 AIP NM_003977.2(AIP): c.-1212_279+578del deletion Likely pathogenic GRCh38 Chromosome 11, 67481947: 67487763
19 AIP NM_003977.2(AIP): c.(?_1)_(*_?)del deletion Likely pathogenic
20 AIP NM_003977.3(AIP): c.100-1025_279+357del1562 deletion Likely pathogenic GRCh37 Chromosome 11, 67253452: 67255013
21 AIP NM_003977.3(AIP): c.100-1025_279+357del1562 deletion Likely pathogenic GRCh38 Chromosome 11, 67485981: 67487542
22 AIP NM_003977.3(AIP): c.138_161del24 (p.Gly47_Arg54del) deletion Likely pathogenic rs267606537 GRCh37 Chromosome 11, 67254515: 67254538
23 AIP NM_003977.3(AIP): c.138_161del24 (p.Gly47_Arg54del) deletion Likely pathogenic rs267606537 GRCh38 Chromosome 11, 67487044: 67487067
24 AIP NM_003977.3(AIP): c.166C> A (p.Arg56Ser) single nucleotide variant Likely pathogenic rs267606538 GRCh37 Chromosome 11, 67254543: 67254543
25 AIP NM_003977.3(AIP): c.166C> A (p.Arg56Ser) single nucleotide variant Likely pathogenic rs267606538 GRCh38 Chromosome 11, 67487072: 67487072
26 AIP NM_003977.3(AIP): c.241C> T (p.Arg81Ter) single nucleotide variant Pathogenic rs267606541 GRCh37 Chromosome 11, 67254618: 67254618
27 AIP NM_003977.3(AIP): c.241C> T (p.Arg81Ter) single nucleotide variant Pathogenic rs267606541 GRCh38 Chromosome 11, 67487147: 67487147
28 AIP NM_003977.3(AIP): c.244_248delGAAGG (p.Glu82Glyfs) deletion Likely pathogenic rs267606542 GRCh37 Chromosome 11, 67254621: 67254625
29 AIP NM_003977.3(AIP): c.244_248delGAAGG (p.Glu82Glyfs) deletion Likely pathogenic rs267606542 GRCh38 Chromosome 11, 67487150: 67487154
30 AIP NM_003977.3(AIP): c.249G> T (p.Gly83=) single nucleotide variant Likely pathogenic rs104895072 GRCh37 Chromosome 11, 67254626: 67254626
31 AIP NM_003977.3(AIP): c.249G> T (p.Gly83=) single nucleotide variant Likely pathogenic rs104895072 GRCh38 Chromosome 11, 67487155: 67487155
32 AIP NM_003977.3(AIP): c.250G> A (p.Glu84Lys) single nucleotide variant Likely pathogenic rs267606543 GRCh37 Chromosome 11, 67254627: 67254627
33 AIP NM_003977.3(AIP): c.250G> A (p.Glu84Lys) single nucleotide variant Likely pathogenic rs267606543 GRCh38 Chromosome 11, 67487156: 67487156
34 AIP NM_003977.3(AIP): c.280-1G> A single nucleotide variant Likely pathogenic rs267606544 GRCh37 Chromosome 11, 67256737: 67256737
35 AIP NM_003977.3(AIP): c.280-1G> A single nucleotide variant Likely pathogenic rs267606544 GRCh38 Chromosome 11, 67489266: 67489266
36 AIP NM_003977.3(AIP): c.286_287delGT (p.Val96Profs) deletion Likely pathogenic rs267606545 GRCh37 Chromosome 11, 67256744: 67256745
37 AIP NM_003977.3(AIP): c.286_287delGT (p.Val96Profs) deletion Likely pathogenic rs267606545 GRCh38 Chromosome 11, 67489273: 67489274
38 AIP NM_003977.3(AIP): c.2T> C (p.Met1Thr) single nucleotide variant Likely pathogenic rs267606546 GRCh37 Chromosome 11, 67250631: 67250631
39 AIP NM_003977.3(AIP): c.2T> C (p.Met1Thr) single nucleotide variant Likely pathogenic rs267606546 GRCh38 Chromosome 11, 67483160: 67483160
40 AIP NM_003977.3(AIP): c.308A> G (p.Lys103Arg) single nucleotide variant Likely pathogenic rs267606548 GRCh37 Chromosome 11, 67256766: 67256766
41 AIP NM_003977.3(AIP): c.308A> G (p.Lys103Arg) single nucleotide variant Likely pathogenic rs267606548 GRCh38 Chromosome 11, 67489295: 67489295
42 AIP NM_003977.3(AIP): c.350delG (p.Gly117Alafs) deletion Likely pathogenic rs267606549 GRCh37 Chromosome 11, 67256808: 67256808
43 AIP NM_003977.3(AIP): c.350delG (p.Gly117Alafs) deletion Likely pathogenic rs267606549 GRCh38 Chromosome 11, 67489337: 67489337
44 AIP NM_003977.3(AIP): c.3_4insC (p.Ala2Argfs) insertion Likely pathogenic rs267606547 GRCh37 Chromosome 11, 67250632: 67250633
45 AIP NM_003977.3(AIP): c.3_4insC (p.Ala2Argfs) insertion Likely pathogenic rs267606547 GRCh38 Chromosome 11, 67483161: 67483162
46 AIP NM_003977.3(AIP): c.404delA (p.His135Leufs) deletion Likely pathogenic rs267606551 GRCh37 Chromosome 11, 67256862: 67256862
47 AIP NM_003977.3(AIP): c.404delA (p.His135Leufs) deletion Likely pathogenic rs267606551 GRCh38 Chromosome 11, 67489391: 67489391
48 AIP NM_003977.3(AIP): c.424C> T (p.Gln142Ter) single nucleotide variant Likely pathogenic rs267606552 GRCh37 Chromosome 11, 67256882: 67256882
49 AIP NM_003977.3(AIP): c.424C> T (p.Gln142Ter) single nucleotide variant Likely pathogenic rs267606552 GRCh38 Chromosome 11, 67489411: 67489411
50 AIP NM_003977.3(AIP): c.468+1G> A single nucleotide variant Likely pathogenic rs267606554 GRCh37 Chromosome 11, 67256927: 67256927

Cosmic variations for Pituitary Adenoma 1, Multiple Types:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM771 PIK3CA pituitary,NS,adenoma,PRL c.3073A>G p.T1025A 3:179234230-179234230 26
2 COSM760 PIK3CA pituitary,NS,adenoma,PRL c.1624G>A p.E542K 3:179218294-179218294 26
3 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 26
4 COSM483 HRAS pituitary,NS,adenoma,GH c.35G>T p.G12V 11:534288-534288 26
5 COSM482 HRAS pituitary,NS,adenoma,PRL c.34G>C p.G12R 11:534289-534289 26
6 COSM27887 GNAS pituitary,NS,adenoma,GH c.601C>T p.R201C 20:58909365-58909365 26
7 COSM27896 GNAS pituitary,NS,adenoma,GH c.680A>G p.Q227R 20:58909541-58909541 26
8 COSM27899 GNAS pituitary,NS,adenoma,GH c.601C>A p.R201S 20:58909365-58909365 26
9 COSM27895 GNAS pituitary,NS,adenoma,GH c.602G>A p.R201H 20:58909366-58909366 26
10 COSM27888 GNAS pituitary,NS,adenoma,GH c.680A>T p.Q227L 20:58909541-58909541 26

Expression for Pituitary Adenoma 1, Multiple Types

Search GEO for disease gene expression data for Pituitary Adenoma 1, Multiple Types.

Pathways for Pituitary Adenoma 1, Multiple Types

GO Terms for Pituitary Adenoma 1, Multiple Types

Cellular components related to Pituitary Adenoma 1, Multiple Types according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.72 GH1 IGF1 IGFBP3 PRL SST
2 extracellular space GO:0005615 9.65 GH1 IGF1 IGFBP3 PRL SST
3 endosome lumen GO:0031904 9.16 GH1 PRL
4 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
5 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Pituitary Adenoma 1, Multiple Types according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.5 IGF1 IGFBP3 PRL
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.49 GH1 IGF1
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.48 GH1 IGF1
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 GH1 IGF1
5 regulation of signaling receptor activity GO:0010469 9.46 GH1 IGF1 PRL SST
6 response to heat GO:0009408 9.43 IGF1 SST
7 regulation of multicellular organism growth GO:0040014 9.4 IGF1 PRL
8 positive regulation of JAK-STAT cascade GO:0046427 9.37 GH1 PRL
9 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.26 GH1 PRL
10 response to nutrient levels GO:0031667 9.13 GH1 IGF1 PRL
11 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.8 GH1 IGF1 IGFBP3

Molecular functions related to Pituitary Adenoma 1, Multiple Types according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 IGF1 PRL SST

Sources for Pituitary Adenoma 1, Multiple Types

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