MCID: PTT004
MIFTS: 50

Pituitary Apoplexy

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Pituitary Apoplexy

MalaCards integrated aliases for Pituitary Apoplexy:

Name: Pituitary Apoplexy 12 59 55 44 15 73

Characteristics:

Orphanet epidemiological data:

59
pituitary apoplexy
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Pituitary Apoplexy

MalaCards based summary : Pituitary Apoplexy is related to gigantism and adenoma. An important gene associated with Pituitary Apoplexy is PRL (Prolactin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucocorticoid receptor regulatory network. The drugs Citric Acid and Enclomiphene have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related phenotypes are bitemporal hemianopia and thunderclap headache

Wikipedia : 76 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

Related Diseases for Pituitary Apoplexy

Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 gigantism 30.0 AIP PRL
2 adenoma 29.6 AIP POMC PRL
3 adenohypophysitis 29.5 POMC PRL
4 diabetes insipidus 29.1 INS POMC PRL
5 empty sella syndrome 29.0 GNRH1 POMC PRL
6 functioning pituitary adenoma 29.0 AIP POMC PRL
7 pituitary tumors 28.9 AIP POMC PRL
8 amenorrhea 28.8 GNRH1 POMC PRL
9 acromegaly 28.7 AIP INS POMC PRL
10 hypopituitarism 28.3 GNRH1 INS POMC PRL
11 chromophobe adenoma 27.6 GNRH1 INS POMC PRL
12 pituitary adenoma 10.4
13 cerebritis 10.3
14 meningitis 10.3
15 endometriosis of uterus 10.3 GNRH1 PRL
16 hypogonadotropism 10.3 GNRH1 PRL
17 aneurysm 10.3
18 pituitary adenoma 1, multiple types 10.3 AIP PRL
19 multiple endocrine neoplasia, type iv 10.2 AIP PRL
20 prostatitis 10.2
21 growth hormone secreting pituitary adenoma 10.2 AIP PRL
22 stroke, ischemic 10.2
23 headache 10.2
24 prostate cancer 10.2
25 cranial nerve palsy 10.2
26 lymphoma 10.1
27 varicocele 10.1 GNRH1 PRL
28 granulosa cell tumor of the ovary 10.0 INS PRL
29 dengue hemorrhagic fever 10.0
30 thrombocytopenia 10.0
31 ptosis 10.0
32 mucositis 10.0
33 bacterial meningitis 10.0
34 hemorrhagic fever 10.0
35 aromatase deficiency 10.0 GNRH1 INS
36 adenocarcinoma 10.0
37 thyroiditis 10.0
38 carotid artery occlusion 10.0
39 lymphocytic hypophysitis 10.0
40 non-functioning pituitary adenoma 10.0
41 acanthosis nigricans 9.9 INS PRL
42 pituitary carcinoma 9.9 POMC PRL
43 sella turcica neoplasm 9.9 POMC PRL
44 tuberculum sellae meningioma 9.9 POMC PRL
45 nelson syndrome 9.9 POMC PRL
46 epidermoid cysts 9.9
47 thrombocytopenic purpura, autoimmune 9.9
48 diabetes mellitus, ketosis-prone 9.9
49 leukemia 9.9
50 meningoencephalitis 9.9

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to Pituitary Apoplexy

Symptoms & Phenotypes for Pituitary Apoplexy

Human phenotypes related to Pituitary Apoplexy:

59 32 (show all 42)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 bitemporal hemianopia 59 32 hallmark (90%) Very frequent (99-80%) HP:0030521
2 thunderclap headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0030907
3 diplopia 59 32 frequent (33%) Frequent (79-30%) HP:0000651
4 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
5 hypergonadotropic hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000815
6 hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0000822
7 oligomenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000876
8 hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0001943
9 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
10 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
11 pituitary adenoma 59 32 frequent (33%) Frequent (79-30%) HP:0002893
12 hyponatremia 59 32 frequent (33%) Frequent (79-30%) HP:0002902
13 cranial nerve paralysis 59 32 frequent (33%) Frequent (79-30%) HP:0006824
14 prolactin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008202
15 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
16 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
17 abnormal kinetic perimetry test 59 32 frequent (33%) Frequent (79-30%) HP:0030591
18 abnormal static automated perimetry test 59 32 frequent (33%) Frequent (79-30%) HP:0030595
19 ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000508
20 photophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000613
21 blurred vision 59 32 occasional (7.5%) Occasional (29-5%) HP:0000622
22 growth hormone deficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000824
23 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
24 pallor 59 32 occasional (7.5%) Occasional (29-5%) HP:0000980
25 coma 59 32 occasional (7.5%) Occasional (29-5%) HP:0001259
26 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
27 abnormality of the cerebrospinal fluid 59 32 occasional (7.5%) Occasional (29-5%) HP:0002921
28 reduced visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0007663
29 mydriasis 59 32 occasional (7.5%) Occasional (29-5%) HP:0011499
30 fatigue 59 32 occasional (7.5%) Occasional (29-5%) HP:0012378
31 galactorrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0100829
32 growth hormone excess 59 32 very rare (1%) Very rare (<4-1%) HP:0000845
33 central diabetes insipidus 59 32 very rare (1%) Very rare (<4-1%) HP:0000863
34 excessive daytime somnolence 59 32 very rare (1%) Very rare (<4-1%) HP:0001262
35 confusion 59 32 very rare (1%) Very rare (<4-1%) HP:0001289
36 normochromic anemia 59 32 very rare (1%) Very rare (<4-1%) HP:0001895
37 abnormality of the caudate nucleus 59 32 very rare (1%) Very rare (<4-1%) HP:0002339
38 trigeminal neuralgia 59 32 very rare (1%) Very rare (<4-1%) HP:0100661
39 headache 59 Frequent (79-30%)
40 hypopituitarism 59 Occasional (29-5%)
41 hypercortisolism 59 Very rare (<4-1%)
42 increased circulating cortisol level 32 very rare (1%) HP:0003118

MGI Mouse Phenotypes related to Pituitary Apoplexy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 POMC PRL AIP GNRH1 INS
2 homeostasis/metabolism MP:0005376 9.65 INS POMC PRL AIP GNRH1
3 integument MP:0010771 9.55 POMC PRL AIP GNRH1 INS
4 liver/biliary system MP:0005370 9.35 POMC PRL AIP GNRH1 INS
5 neoplasm MP:0002006 8.92 POMC PRL AIP GNRH1

Drugs & Therapeutics for Pituitary Apoplexy

Drugs for Pituitary Apoplexy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
2
Enclomiphene Investigational Not Applicable 15690-57-0
3 Anticoagulants Not Applicable
4 Calcium, Dietary Not Applicable
5 Chelating Agents Not Applicable
6 Clomiphene Not Applicable
7 Estrogen Antagonists Not Applicable
8 Estrogen Receptor Modulators Not Applicable
9 Estrogens Not Applicable
10 Fertility Agents Not Applicable
11 Hormone Antagonists Not Applicable
12 Hormones Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
14 Selective Estrogen Receptor Modulators Not Applicable
15 Zuclomiphene Not Applicable
16 Citrate Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome Unknown status NCT01573858 Not Applicable
2 Prevalence of a High-intensity Signal of the Oculomotor Nerve on T2 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03135574
3 Prevalence of Contrast Enhancement of the Oculomotor Nerve on 3D PD T1 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03269682

Search NIH Clinical Center for Pituitary Apoplexy

Cochrane evidence based reviews: pituitary apoplexy

Genetic Tests for Pituitary Apoplexy

Anatomical Context for Pituitary Apoplexy

MalaCards organs/tissues related to Pituitary Apoplexy:

41
Pituitary, Brain, Testes, Prostate, Caudate Nucleus, Ovary, Thyroid

Publications for Pituitary Apoplexy

Articles related to Pituitary Apoplexy:

(show top 50) (show all 580)
# Title Authors Year
1
Pituitary Apoplexy With Bilateral Oculomotor Nerve Palsy. ( 29977453 )
2018
2
Clinical and imaging features of pituitary apoplexy and role of imaging in differentiation of clinical mimics. ( 29675363 )
2018
3
Angioplasty is an Effective Treatment for Vasospasm Following Pituitary Apoplexy and Tumor Resection. ( 29593947 )
2018
4
Landscape of Molecular Events in Pituitary Apoplexy. ( 29615979 )
2018
5
Letter to the Editor Regarding &amp;quot;Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center&amp;quot;. ( 29232809 )
2018
6
Rathke's Cleft Cyst or Pituitary Apoplexy: A Case Report and Literature Review. ( 29610617 )
2018
7
Pituitary Apoplexy during Treatment of Prolactinoma with Cabergoline. ( 29492132 )
2018
8
Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer. ( 29717570 )
2018
9
Pituitary apoplexy following lumbar fusion surgery in prone position: A case report. ( 29742711 )
2018
10
Pituitary Apoplexy with a Binasal Visual Field Defect. ( 29534208 )
2018
11
Pituitary Apoplexy Presenting as Ophthalmoplegia and Altered Level of Consciousness without Headache. ( 29854489 )
2018
12
The Outcomes of Pituitary Apoplexy with Conservative Treatment: Experiences at a Single Institution. ( 29709755 )
2018
13
In Reply to the Letter to the Editor Regarding &amp;quot;Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center&amp;quot;. ( 29232810 )
2018
14
Neuro-Endocrine Recovery After Pituitary Apoplexy: Prolactin as a Predictive Factor. ( 29966153 )
2018
15
Corrigendum to &amp;quot;In Reply to the Letter to the Editor Regarding &amp;quot;Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center&amp;quot; [World Neurosurgery 109 (2018) 502]. ( 29398620 )
2018
16
Myasthenia gravis imitating pituitary apoplexy in macroprolactinoma. ( 29860715 )
2018
17
Presenting Symptoms of Pituitary Apoplexy. ( 28437813 )
2017
18
Postoperative Neurologic Outcome in Patients with Pituitary Apoplexy After Transsphenoidal Surgery. ( 29191540 )
2017
19
Repeated Headache as Presentation of Pituitary Apoplexy in the Adolescent Population: Unusual Entity with Review of Literature. ( 28936095 )
2017
20
Pituitary Apoplexy Presenting as Status Migrainosus. ( 28181226 )
2017
21
New Oral Anticoagulants and Pituitary Apoplexy. ( 28437880 )
2017
22
Endoscopic Endonasal Surgery for Treatment of Pituitary Apoplexy: 16 Years of Experience in a Specialized Pituitary Center: Endoscopic Surgery for Pituitary Apoplexy. ( 28867316 )
2017
23
Gestational Pituitary Apoplexy. ( 28553611 )
2017
24
Indomethacin-Responsive Paroxysmal Hemicrania in an Elderly Man: An Unusual Presentation of Pituitary Apoplexy. ( 28980712 )
2017
25
Pituitary apoplexy presenting as a peripheral rim enhancing parasellar mass lesion with dural enhancement along the tentorium. ( 28581357 )
2017
26
Delayed Onset of Isolated Unilateral Oculomotor Nerve Palsy Caused by Post-Traumatic Pituitary Apoplexy: A Case Report. ( 28979174 )
2017
27
Hypersomatotropism induced secondary polycythaemia leading to spontaneous pituitary apoplexy resulting in cure of acromegaly and remission of polycythaemia: 'The virtuous circle'. ( 29222208 )
2017
28
Surgical intervention for pituitary apoplexy: an analysis of functional outcomes. ( 28946177 )
2017
29
Sphenoid sinus mucosal thickening in the acute phase of pituitary apoplexy. ( 28421421 )
2017
30
Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study. ( 28853001 )
2017
31
Pituitary apoplexy - A single center retrospective study from the neurosurgical perspective and review of the literature. ( 29055223 )
2017
32
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
33
A rare case of spontaneous Cushing disease remission induced by pituitary apoplexy. ( 28251551 )
2017
34
Pituitary apoplexy: a rare complication of leuprolide therapy in prostate cancer treatment. ( 28710301 )
2017
35
Pituitary Ring Sign Plus Sphenoid Sinus Mucosal Thickening: Neuroimaging Signs of Pituitary Apoplexy. ( 29344069 )
2017
36
Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75-Case Series From a Tertiary Care Center. ( 28669873 )
2017
37
Intrasellar dermoid cyst mimicking pituitary apoplexy: A case report and review of the literature. ( 28601571 )
2017
38
The impact of surgical timing on visual outcome in pituitary apoplexy: Literature review and case illustration. ( 28217395 )
2017
39
Management dilemmas in a rare case of pituitary apoplexy in the setting of dengue hemorrhagic fever. ( 28217383 )
2017
40
Acute Ischaemic Stroke as a Manifestation of Pituitary Apoplexy in a Young Lady. ( 28658829 )
2017
41
Pituitary apoplexy and rivaroxaban. ( 28831662 )
2017
42
Pituitary Apoplexy: Should Endoscopic Surgery Be the Gold Standard? ( 29288106 )
2017
43
SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of pituitary apoplexy in adult patients. ( 27935817 )
2016
44
Pituitary apoplexy causing spontaneous remission of acromegaly following long-acting octreotide therapy: a rare drug side effect or just a coincidence. ( 27123308 )
2016
45
Surgical versus non-surgical treatment for pituitary apoplexy: A systematic review and meta-analysis. ( 27772771 )
2016
46
Management of pituitary apoplexy. ( 27006559 )
2016
47
Multidisciplinary Management of Pituitary Apoplexy. ( 28074095 )
2016
48
A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report. ( 27738402 )
2016
49
Pituitary apoplexy presenting as diabetic ketoacidosis: A great simulator? Case Report. ( 26994379 )
2016
50
A case of pituitary apoplexy masquerading as subarachnoid hemorrhage. ( 27014446 )
2016

Variations for Pituitary Apoplexy

Expression for Pituitary Apoplexy

Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for Pituitary Apoplexy

Pathways related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 AIP INS POMC
2 10.87 POMC PRL
3 10.32 INS PRL

GO Terms for Pituitary Apoplexy

Cellular components related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 GNRH1 INS POMC PRL
2 secretory granule lumen GO:0034774 9.16 INS POMC
3 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose homeostasis GO:0042593 9.32 INS POMC
2 female pregnancy GO:0007565 9.26 GNRH1 PRL
3 response to nutrient levels GO:0031667 9.16 INS PRL
4 cell-cell signaling GO:0007267 9.13 GNRH1 INS POMC
5 regulation of signaling receptor activity GO:0010469 8.92 GNRH1 INS POMC PRL

Molecular functions related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GNRH1 INS POMC PRL

Sources for Pituitary Apoplexy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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