MCID: PTT004
MIFTS: 48

Pituitary Apoplexy

Categories: Endocrine diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pituitary Apoplexy

Summaries for Pituitary Apoplexy

MalaCards based summary : Pituitary Apoplexy is related to adenoma and acromegaly. An important gene associated with Pituitary Apoplexy is PRL (Prolactin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Signaling events mediated by PTP1B. The drugs Citric Acid and Enclomiphene have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related phenotypes are ptosis and diplopia

Wikipedia : 76 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

Related Diseases for Pituitary Apoplexy

Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.5 AIP POMC PRL
2 acromegaly 30.3 AIP INS POMC PRL
3 diabetes insipidus 30.2 INS POMC PRL
4 functioning pituitary adenoma 30.0 POMC PRL
5 hypopituitarism 29.9 GNRH1 INS POMC PRL
6 gigantism 29.9 AIP PRL
7 empty sella syndrome 29.9 GNRH1 POMC PRL
8 adenohypophysitis 29.8 POMC PRL
9 pituitary tumors 29.7 AIP POMC PRL
10 amenorrhea 29.7 GNRH1 POMC PRL
11 conn's syndrome 29.5 POMC PRL
12 chromophobe adenoma 29.2 GNRH1 INS POMC PRL
13 pituitary adenoma 10.4
14 meningitis 10.4
15 headache 10.4
16 stroke, ischemic 10.3
17 prostate cancer 10.3
18 cranial nerve palsy 10.3
19 thrombocytopenia 10.2
20 lymphoma 10.2
21 dengue hemorrhagic fever 10.2
22 ptosis 10.2
23 bacterial meningitis 10.2
24 hemorrhagic fever 10.2
25 lymphocytic hypophysitis 10.2
26 adenocarcinoma 10.1
27 thyroiditis 10.1
28 carotid artery occlusion 10.1
29 hypogonadotropism 10.1 GNRH1 PRL
30 pelvic varices 10.1 GNRH1 PRL
31 growth hormone secreting pituitary adenoma 10.1 AIP PRL
32 pituitary adenoma 1, multiple types 10.1 AIP PRL
33 multiple endocrine neoplasia, type iv 10.1 AIP PRL
34 adenomyosis 10.0 GNRH1 PRL
35 varicocele 10.0 GNRH1 PRL
36 granulosa cell tumor of the ovary 10.0 INS PRL
37 female reproductive system disease 10.0 GNRH1 PRL
38 multiple endocrine neoplasia, type i 10.0 INS PRL
39 reproductive system disease 10.0 GNRH1 PRL
40 breast cancer 10.0
41 epidermoid cysts 10.0
42 thrombocytopenic purpura, autoimmune 10.0
43 myocardial infarction 10.0
44 diabetes mellitus, ketosis-prone 10.0
45 meningoencephalitis 10.0
46 optic neuritis 10.0
47 neuritis 10.0
48 ischemia 10.0
49 purpura 10.0
50 neuropathy 10.0

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to Pituitary Apoplexy

Symptoms & Phenotypes for Pituitary Apoplexy

Human phenotypes related to Pituitary Apoplexy:

59 32 (show all 43)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000508
2 diplopia 59 32 frequent (33%) Frequent (79-30%) HP:0000651
3 hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0000822
4 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
5 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
6 photophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000613
7 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
8 cranial nerve paralysis 59 32 frequent (33%) Frequent (79-30%) HP:0006824
9 fatigue 59 32 occasional (7.5%) Occasional (29-5%) HP:0012378
10 hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0001943
11 pallor 59 32 occasional (7.5%) Occasional (29-5%) HP:0000980
12 reduced visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0007663
13 hypergonadotropic hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000815
14 coma 59 32 occasional (7.5%) Occasional (29-5%) HP:0001259
15 hyponatremia 59 32 frequent (33%) Frequent (79-30%) HP:0002902
16 growth hormone excess 59 32 very rare (1%) Very rare (<4-1%) HP:0000845
17 pituitary adenoma 59 32 frequent (33%) Frequent (79-30%) HP:0002893
18 blurred vision 59 32 occasional (7.5%) Occasional (29-5%) HP:0000622
19 abnormality of the cerebrospinal fluid 59 32 occasional (7.5%) Occasional (29-5%) HP:0002921
20 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
21 galactorrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0100829
22 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
23 confusion 59 32 very rare (1%) Very rare (<4-1%) HP:0001289
24 mydriasis 59 32 occasional (7.5%) Occasional (29-5%) HP:0011499
25 excessive daytime somnolence 59 32 very rare (1%) Very rare (<4-1%) HP:0001262
26 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
27 bitemporal hemianopia 59 32 hallmark (90%) Very frequent (99-80%) HP:0030521
28 abnormal kinetic perimetry test 59 32 frequent (33%) Frequent (79-30%) HP:0030591
29 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
30 prolactin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008202
31 trigeminal neuralgia 59 32 very rare (1%) Very rare (<4-1%) HP:0100661
32 growth hormone deficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000824
33 central diabetes insipidus 59 32 very rare (1%) Very rare (<4-1%) HP:0000863
34 oligomenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000876
35 thunderclap headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0030907
36 normochromic anemia 59 32 very rare (1%) Very rare (<4-1%) HP:0001895
37 abnormal static automated perimetry test 59 32 frequent (33%) Frequent (79-30%) HP:0030595
38 hypercortisolism 59 Very rare (<4-1%)
39 headache 59 Frequent (79-30%)
40 increased circulating cortisol level 32 very rare (1%) HP:0003118
41 hypopituitarism 59 Occasional (29-5%)
42 abnormality of the caudate nucleus 59 Very rare (<4-1%)
43 abnormal caudate nucleus morphology 32 very rare (1%) HP:0002339

MGI Mouse Phenotypes related to Pituitary Apoplexy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 AIP GNRH1 INS POMC PRL
2 homeostasis/metabolism MP:0005376 9.65 AIP GNRH1 INS POMC PRL
3 integument MP:0010771 9.55 AIP GNRH1 INS POMC PRL
4 liver/biliary system MP:0005370 9.35 AIP GNRH1 INS POMC PRL
5 neoplasm MP:0002006 8.92 AIP GNRH1 POMC PRL

Drugs & Therapeutics for Pituitary Apoplexy

Drugs for Pituitary Apoplexy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
2
Enclomiphene Investigational Not Applicable 15690-57-0
3 Estrogen Antagonists Not Applicable
4 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
5 Citrate Not Applicable
6 Estrogen Receptor Antagonists Not Applicable
7 Selective Estrogen Receptor Modulators Not Applicable
8 Anticoagulants Not Applicable
9 Zuclomiphene Not Applicable
10 Chelating Agents Not Applicable
11 Hormones Not Applicable
12 Estrogens Not Applicable
13 Estrogen Receptor Modulators Not Applicable
14 Clomiphene Not Applicable
15 Calcium, Dietary Not Applicable
16 Hormone Antagonists Not Applicable
17 Fertility Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome Unknown status NCT01573858 Not Applicable
2 Prevalence of a High-intensity Signal of the Oculomotor Nerve on T2 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03135574
3 Prevalence of Contrast Enhancement of the Oculomotor Nerve on 3D PD T1 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03269682

Search NIH Clinical Center for Pituitary Apoplexy

Cochrane evidence based reviews: pituitary apoplexy

Genetic Tests for Pituitary Apoplexy

Anatomical Context for Pituitary Apoplexy

MalaCards organs/tissues related to Pituitary Apoplexy:

41
Pituitary, Brain, Testes, Prostate, Caudate Nucleus, Thyroid, Myeloid

Publications for Pituitary Apoplexy

Articles related to Pituitary Apoplexy:

(show top 50) (show all 609)
# Title Authors Year
1
Pituitary Apoplexy With Bilateral Oculomotor Nerve Palsy. ( 29977453 )
2018
2
Clinical and imaging features of pituitary apoplexy and role of imaging in differentiation of clinical mimics. ( 29675363 )
2018
3
Angioplasty is an Effective Treatment for Vasospasm Following Pituitary Apoplexy and Tumor Resection. ( 29593947 )
2018
4
Landscape of Molecular Events in Pituitary Apoplexy. ( 29615979 )
2018
5
Letter to the Editor Regarding &amp;quot;Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center&amp;quot;. ( 29232809 )
2018
6
Rathke's Cleft Cyst or Pituitary Apoplexy: A Case Report and Literature Review. ( 29610617 )
2018
7
Pituitary Apoplexy during Treatment of Prolactinoma with Cabergoline. ( 29492132 )
2018
8
Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer. ( 29717570 )
2018
9
Pituitary apoplexy following lumbar fusion surgery in prone position: A case report. ( 29742711 )
2018
10
Pituitary Apoplexy with a Binasal Visual Field Defect. ( 29534208 )
2018
11
Pituitary Apoplexy Presenting as Ophthalmoplegia and Altered Level of Consciousness without Headache. ( 29854489 )
2018
12
The Outcomes of Pituitary Apoplexy with Conservative Treatment: Experiences at a Single Institution. ( 29709755 )
2018
13
In Reply to the Letter to the Editor Regarding &amp;quot;Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center&amp;quot;. ( 29232810 )
2018
14
Neuro-Endocrine Recovery After Pituitary Apoplexy: Prolactin as a Predictive Factor. ( 29966153 )
2018
15
Corrigendum to &amp;quot;In Reply to the Letter to the Editor Regarding &amp;quot;Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center&amp;quot; [World Neurosurgery 109 (2018) 502]. ( 29398620 )
2018
16
Myasthenia gravis imitating pituitary apoplexy in macroprolactinoma. ( 29860715 )
2018
17
Pituitary apoplexy secondary to metastatic breast carcinoma into a gonadotroph cell adenoma of the pituitary. ( 30475069 )
2018
18
Unilateral Tuberothalamic Artery Ischemia Caused by Pituitary Apoplexy. ( 30029284 )
2018
19
Cystic Lymphocytic Hypophysitis Mimicking Pituitary Apoplexy: Daunting Challenge. ( 29981909 )
2018
20
A Perplexing Case of Pituitary Apoplexy Masquerading as Recurrent Meningitis. ( 30480002 )
2018
21
Pituitary Apoplexy: Should Endoscopic Surgery Be the Gold Standard? ( 29288106 )
2018
22
Clinical and biochemical characteristics of patients presenting with pituitary apoplexy. ( 30139818 )
2018
23
Pituitary apoplexy after regadenoson myocardial perfusion scan. ( 30168027 )
2018
24
Pituitary Apoplexy in Long-Term Cabergoline User During Thrombocytopenia Due to Chemotherapy for Chronic Myelocytic Leukemia. ( 30189305 )
2018
25
Pituitary Apoplexy following Endoscopic Retrograde Cholangiopancreatography. ( 30292038 )
2018
26
Bilateral Optic Tract Hyperintensity due to Pituitary Apoplexy. ( 30333408 )
2018
27
Conservative treatment cures an elderly pituitary apoplexy patient with oculomotor paralysis and optic nerve compression: a case report and systematic review of the literature. ( 30349217 )
2018
28
Pituitary Apoplexy Producing Internal Carotid and Basilar Artery Compression: A Rare Case Report. ( 30459913 )
2018
29
Pituitary apoplexy. ( 30510048 )
2018
30
Presenting Symptoms of Pituitary Apoplexy. ( 28437813 )
2017
31
Postoperative Neurologic Outcome in Patients with Pituitary Apoplexy After Transsphenoidal Surgery. ( 29191540 )
2017
32
Repeated Headache as Presentation of Pituitary Apoplexy in the Adolescent Population: Unusual Entity with Review of Literature. ( 28936095 )
2017
33
Pituitary Apoplexy Presenting as Status Migrainosus. ( 28181226 )
2017
34
New Oral Anticoagulants and Pituitary Apoplexy. ( 28437880 )
2017
35
Endoscopic Endonasal Surgery for Treatment of Pituitary Apoplexy: 16 Years of Experience in a Specialized Pituitary Center: Endoscopic Surgery for Pituitary Apoplexy. ( 28867316 )
2017
36
Gestational Pituitary Apoplexy. ( 28553611 )
2017
37
Indomethacin-Responsive Paroxysmal Hemicrania in an Elderly Man: An Unusual Presentation of Pituitary Apoplexy. ( 28980712 )
2017
38
Pituitary apoplexy presenting as a peripheral rim enhancing parasellar mass lesion with dural enhancement along the tentorium. ( 28581357 )
2017
39
Delayed Onset of Isolated Unilateral Oculomotor Nerve Palsy Caused by Post-Traumatic Pituitary Apoplexy: A Case Report. ( 28979174 )
2017
40
Hypersomatotropism induced secondary polycythaemia leading to spontaneous pituitary apoplexy resulting in cure of acromegaly and remission of polycythaemia: 'The virtuous circle'. ( 29222208 )
2017
41
Surgical intervention for pituitary apoplexy: an analysis of functional outcomes. ( 28946177 )
2017
42
Sphenoid sinus mucosal thickening in the acute phase of pituitary apoplexy. ( 28421421 )
2017
43
Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study. ( 28853001 )
2017
44
Pituitary apoplexy - A single center retrospective study from the neurosurgical perspective and review of the literature. ( 29055223 )
2017
45
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
46
A rare case of spontaneous Cushing disease remission induced by pituitary apoplexy. ( 28251551 )
2017
47
Pituitary apoplexy: a rare complication of leuprolide therapy in prostate cancer treatment. ( 28710301 )
2017
48
Pituitary Ring Sign Plus Sphenoid Sinus Mucosal Thickening: Neuroimaging Signs of Pituitary Apoplexy. ( 29344069 )
2017
49
Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75-Case Series From a Tertiary Care Center. ( 28669873 )
2017
50
Intrasellar dermoid cyst mimicking pituitary apoplexy: A case report and review of the literature. ( 28601571 )
2017

Variations for Pituitary Apoplexy

Expression for Pituitary Apoplexy

Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for Pituitary Apoplexy

Pathways related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 POMC PRL
2 10.32 INS PRL

GO Terms for Pituitary Apoplexy

Cellular components related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule lumen GO:0034774 9.26 INS POMC
2 extracellular space GO:0005615 9.26 GNRH1 INS POMC PRL
3 secretory granule GO:0030141 9.16 POMC PRL
4 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.4 GNRH1 PRL
2 response to ethanol GO:0045471 9.37 GNRH1 PRL
3 cell-cell signaling GO:0007267 9.33 GNRH1 INS POMC
4 glucose homeostasis GO:0042593 9.32 INS POMC
5 female pregnancy GO:0007565 9.26 GNRH1 PRL
6 ovulation cycle GO:0042698 8.96 GNRH1 PRL
7 regulation of signaling receptor activity GO:0010469 8.92 GNRH1 INS POMC PRL

Molecular functions related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GNRH1 INS POMC PRL

Sources for Pituitary Apoplexy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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