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MCID: PTT008
MIFTS: 49

Pituitary Carcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pituitary Carcinoma

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MalaCards integrated aliases for Pituitary Carcinoma:

Name: Pituitary Carcinoma 12 53 59 15 73
Malignant Neoplasm of Pituitary Gland 73
Carcinoma of the Pituitary Gland 12
Pituitary Cancer 53

Characteristics:

Orphanet epidemiological data:

59
pituitary carcinoma
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 34 33


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Summaries for Pituitary Carcinoma

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MalaCards based summary : Pituitary Carcinoma, also known as malignant neoplasm of pituitary gland, is related to hormone producing pituitary cancer and prolactin producing pituitary tumor. An important gene associated with Pituitary Carcinoma is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Cushing syndrome. The drugs Nivolumab and Lapatinib have been mentioned in the context of this disorder. Affiliated tissues include pituitary, spinal cord and liver, and related phenotypes are ataxia and hearing impairment

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Related Diseases for Pituitary Carcinoma

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Diseases related to Pituitary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 hormone producing pituitary cancer 33.3 GNAS SST
2 prolactin producing pituitary tumor 31.7 PRL SST
3 adenoma 29.8 GNAS POMC PRL SST
4 pituitary tumors 29.8 GNAS POMC PRL SST
5 pituitary adenoma 29.7 GNAS MEG3
6 acromegaly 29.6 GNAS POMC PRL SST
7 meningioma, radiation-induced 29.4 MEG3 SST
8 hypopituitarism 29.4 CRH POMC PRL
9 multiple endocrine neoplasia, type i 29.1 CHGA GNAS PRL SST
10 bronchus adenoma 10.2 POMC SST
11 bronchial adenomas/carcinoids childhood 10.2 POMC SST
12 acidophil adenoma 10.2 POMC SST
13 lung oat cell carcinoma 10.2 CHGA POMC
14 acute thyroiditis 10.2 CHGA POMC
15 olfactory nerve neoplasm 10.2 CHGA POMC
16 adenoma of the pancreas 10.2 CHGA SST
17 gastrointestinal neuroendocrine benign tumor 10.2 CHGA SST
18 gastrointestinal neuroendocrine tumor 10.2 CHGA SST
19 gastric neuroendocrine neoplasm 10.2 CHGA SST
20 syndrome of inappropriate antidiuretic hormone 10.1 CHGA POMC
21 glucagonoma 10.1 CHGA SST
22 insulinomatosis and diabetes mellitus 10.1 CHGA SST
23 adenohypophysitis 10.1 POMC PRL
24 vipoma 10.1 CHGA SST
25 cervix small cell carcinoma 10.1 CHGA POMC
26 gangliocytoma 10.1 CRH POMC
27 pancreatoblastoma 10.1 CHGA SST
28 carcinoid tumors, intestinal 10.1 CHGA SST
29 pituitary apoplexy 10.1 POMC PRL
30 somatostatinoma 10.1 CHGA SST
31 sella turcica neoplasm 10.1 POMC PRL
32 tuberculum sellae meningioma 10.1 POMC PRL
33 acth deficiency, isolated 10.1 CRH POMC
34 duodenal gastrinoma 10.1 CHGA SST
35 gastrinoma 10.1 CHGA SST
36 empty sella syndrome 10.1 POMC PRL
37 cranial nerve malignant neoplasm 10.1 CHGA POMC
38 hypoadrenalism 10.1 CRH POMC
39 carcinoid syndrome 10.1 CHGA SST
40 zollinger-ellison syndrome 10.1 CHGA SST
41 fasting hypoglycemia 10.1 CRH POMC
42 adrenal cortical hypofunction 10.1 CRH POMC
43 pancreatic cystadenoma 10.1 CHGA SST
44 abducens nerve disease 10.1 POMC PRL
45 malignant pheochromocytoma 10.1 CHGA SST
46 diabetes insipidus, neurohypophyseal 10.1 POMC PRL
47 withdrawal disorder 10.1 CRH POMC
48 mixed ductal-endocrine carcinoma 10.1 CHGA SST
49 sex differentiation disease 10.1 POMC PRL
50 islet cell tumor 10.1 CHGA SST

Graphical network of the top 20 diseases related to Pituitary Carcinoma:



Diseases related to Pituitary Carcinoma
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Symptoms & Phenotypes for Pituitary Carcinoma

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Human phenotypes related to Pituitary Carcinoma:

59 32 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001251
2 hearing impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0000365
3 diabetes insipidus 59 32 very rare (1%) Very rare (<4-1%) HP:0000873
4 growth hormone excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000845
5 pituitary prolactin cell adenoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0006767
6 pituitary growth hormone cell adenoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0011760
7 pituitary corticotropic cell adenoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0008291
8 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
9 spinal cord lesion 59 32 occasional (7.5%) Occasional (29-5%) HP:0100561
10 increased circulating acth level 59 32 hallmark (90%) Very frequent (99-80%) HP:0003154
11 prolactin excess 59 32 hallmark (90%) Very frequent (99-80%) HP:0000870
12 pituitary carcinoma 59 32 obligate (100%) Obligate (100%) HP:0011763
13 enlarged pituitary gland 59 32 frequent (33%) Frequent (79-30%) HP:0012505
14 hypopituitarism 59 32 frequent (33%) Frequent (79-30%) HP:0040075
15 progressive visual field defects 59 32 frequent (33%) Frequent (79-30%) HP:0007987
16 malignant neoplasm of the central nervous system 59 32 hallmark (90%) Very frequent (99-80%) HP:0100836
17 pituitary gonadotropic cell adenoma 59 32 very rare (1%) Very rare (<4-1%) HP:0011759
18 pituitary thyrotropic cell adenoma 59 32 very rare (1%) Very rare (<4-1%) HP:0011762
19 reduced visual acuity 32 frequent (33%) HP:0007663
20 hemianopsia 59 Frequent (79-30%)
21 abnormality of central motor function 59 Occasional (29-5%)
22 mildly reduced visual acuity 59 Frequent (79-30%)
23 hyperpituitarism 59 Occasional (29-5%)
24 hemianopia 32 frequent (33%) HP:0012377

MGI Mouse Phenotypes related to Pituitary Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 CHGA CRH GNAS POMC PRL
2 nervous system MP:0003631 9.63 CHGA CRH GNAS POMC PRL SST
3 liver/biliary system MP:0005370 9.56 CRH GNAS POMC PRL
4 no phenotypic analysis MP:0003012 9.35 CHGA CRH GNAS POMC SST
5 renal/urinary system MP:0005367 8.92 CHGA CRH GNAS POMC
Sources

Drugs & Therapeutics for Pituitary Carcinoma

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Drugs for Pituitary Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2
Lapatinib Approved March 2007, Investigational Phase 2 388082-78-8, 231277-92-2 208908 9941095
3 Immunoglobulins Phase 2
4 Immunologic Factors Phase 2
5 Antibodies, Monoclonal Phase 2
6 Antibodies Phase 2
7 Protein Kinase Inhibitors Phase 2
8
Dactinomycin Approved, Investigational 50-76-0 457193 2019
9
Cyclophosphamide Approved, Investigational 6055-19-2, 50-18-0 2907
10
Vincristine Approved, Investigational 57-22-7, 2068-78-2 5978
11
Ifosfamide Approved 3778-73-2 3690
12
Doxorubicin Approved, Investigational 23214-92-8 31703
13
Doxil Approved June 1999 31703
14
Isophosphamide mustard 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
2 Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy Recruiting NCT00939523 Phase 2 Lapatinib
3 Identification of GENEtic Markers of Aggressiveness and Malignancy by Array Comparative Genomic Hybrization Analysis (CGH) Completed NCT01903967
4 PITUItary Carcinoma or Aggressive Tumors REgistry -Lyon Recruiting NCT02854228
5 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158

Search NIH Clinical Center for Pituitary Carcinoma

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Genetic Tests for Pituitary Carcinoma

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Anatomical Context for Pituitary Carcinoma

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MalaCards organs/tissues related to Pituitary Carcinoma:

41
Pituitary, Spinal Cord, Liver, Lung, Thyroid, Pancreas, Cortex
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Publications for Pituitary Carcinoma

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Articles related to Pituitary Carcinoma:

(show top 50) (show all 138)
# Title Authors Year
1
Prolactin Secreting Pituitary Carcinoma with Extracranial Spread Presenting with Pathological Fracture of Femur. ( 29456370 )
2018
2
Corticotrophic pituitary carcinoma with cervical metastases: case series and literature review. ( 29404894 )
2018
3
Neuro-Ophthalmic Manifestations of Pituitary Carcinoma. ( 29315125 )
2018
4
Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma). ( 29299820 )
2018
5
Combined modalities of surgery, radiotherapy, radiosurgery and chemotherapy for invasive pituitary carcinoma. ( 29525560 )
2018
6
Prolactin-Producing Pituitary Carcinoma, Hypopituitarism, and Graves' Disease-Report of a Challenging Case and Literature Review. ( 29928263 )
2018
7
Marked Response of a Hypermutated ACTH-Secreting Pituitary Carcinoma to Ipilimumab and Nivolumab. ( 30085142 )
2018
8
Long-term survival following transformation of an adrenocorticotropic hormone secreting pituitary macroadenoma to a silent corticotroph pituitary carcinoma: Case report. ( 30447452 )
2018
9
Identification of Novel Genes Involved in the Pathogenesis of an ACTH-Secreting Pituitary Carcinoma: A Case Report and Literature Review. ( 30460199 )
2018
10
A Case of Pituitary Carcinoma Initially Diagnosed as an Ectopic Growth Hormone Producing Pituitary Adenoma with a High Ki-67 Labeling Index. ( 28586933 )
2017
11
Pituitary Carcinoma in a Patient with an SDHB Mutation. ( 28284009 )
2017
12
Failure of a second temozolomide cycle in a patient with a prolactin-secreting pituitary carcinoma. ( 29137963 )
2017
13
Successful treatment of leptomeningeally metastasised pituitary carcinoma with temozolomide. ( 29256415 )
2017
14
Cytomorphology of metastatic pituitary carcinoma to the bone. ( 28267302 )
2017
15
Seeding of a Pituitary Adenoma or Atypical Pituitary Carcinoma? ( 28589060 )
2017
16
Metastatic Pituitary Carcinoma to Cervical Lymph Node: Diagnosis by Fine Needle Aspiration and Review of the Literature. ( 28399532 )
2017
17
Successful treatment of pituitary carcinoma with concurrent radiation, temozolomide, and bevacizumab after resection. ( 28291643 )
2017
18
Meningeal dissemination of a pituitary carcinoma to the cauda equina in a dog. ( 28761190 )
2017
19
Pituitary carcinoma: A case report and discussion of potential value of combined use of Ga-68 DOTATATE and F-18 FDG PET/CT scan to better choose therapy. ( 28840066 )
2017
20
Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing's disease. ( 28420444 )
2017
21
Corticotroph Pituitary Carcinoma in a Patient With Lynch Syndrome (LS) and Pituitary Tumors in a Nationwide LS Cohort. ( 28938458 )
2017
22
Significant response of pituitary carcinoma to carboplatin, leucovorin and fluorouracil chemotherapy: a pediatric case report and review of the literature. ( 28667593 )
2017
23
Response of silent corticotroph pituitary carcinoma to chemotherapy: case report. ( 27150544 )
2016
24
Prolactin-Secreting Pituitary Carcinoma with Dural Metastasis: Diagnosis, Treatment, and Future Directions. ( 27157283 )
2016
25
Genetic aspects of pituitary carcinoma: A systematic review. ( 27893664 )
2016
26
Secreting Follicle-Stimulating Hormone Pituitary Carcinoma with Cervical Metastasis. ( 27449685 )
2016
27
Radiotherapy with concurrent temozolomide for the management of extraneural metastases in pituitary carcinoma. ( 27106209 )
2016
28
Temozolomide therapy: Focus on patients with pituitary carcinoma. ( 27365946 )
2016
29
Pituitary carcinoma with intraspinal metastasis: report of two cases and review of the literature. ( 26464743 )
2015
30
Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing's Disease to Pituitary Carcinoma. ( 26366311 )
2015
31
MicroRNA involvement in a metastatic non-functioning pituitary carcinoma. ( 25862551 )
2015
32
Diagnosis and Treatment of Pituitary Carcinoma. ( 26564466 )
2015
33
A case report of feline pituitary carcinoma with hypercortisolism. ( 24025433 )
2014
34
The Use of 68Ga DOTATATE PET/CT for Diagnostic Assessment and Monitoring of 177Lu DOTATATE Therapy in Pituitary Carcinoma. ( 25275413 )
2014
35
Pituitary carcinoma with endolymphatic sac metastasis. ( 23645293 )
2014
36
Invasive adenoma and pituitary carcinoma: a SEER database analysis. ( 24526366 )
2014
37
Pituitary carcinoma with fourth ventricle metastasis: treatment by excision and Gamma-knife radiosurgery. ( 24272034 )
2014
38
Drop metastasis of adrenocorticotropic hormone-producing pituitary carcinoma to the cauda equina. ( 25346823 )
2014
39
Multiple cerebral hemorrhagic foci from metastases during temozolomide treatment in a patient with corticotroph pituitary carcinoma. ( 24823463 )
2014
40
Improvement in Diagnosis of Metastatic Pituitary Carcinoma by 68Ga DOTATATE PET/CT. ( 24873798 )
2014
41
Lesions of the petrous ridge: metastatic pituitary carcinoma with discussion of differential diagnosis. ( 24622018 )
2014
42
Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )
2013
43
Pituitary carcinoma in situ. ( 23425649 )
2013
44
Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide. ( 23955641 )
2013
45
Pituitary carcinoma: a devastating disease in need of an earlier diagnosis and of effective therapies. ( 22120355 )
2013
46
Long-term follow-up of growth hormone-producing pituitary carcinoma with multiple spinal metastases following multiple surgeries: case report. ( 24077272 )
2013
47
Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. ( 24455332 )
2013
48
Adrenocorticotropic hormone-producing pituitary carcinoma with intracranial metastases. ( 22079280 )
2013
49
Pituitary carcinoma. ( 22082969 )
2013
50
Long-term control of a MEN1 prolactin secreting pituitary carcinoma after temozolomide treatment. ( 22520146 )
2012
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Variations for Pituitary Carcinoma

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Expression for Pituitary Carcinoma

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Search GEO for disease gene expression data for Pituitary Carcinoma.
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Pathways for Pituitary Carcinoma

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Pathways related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 66
Show member pathways
 12.99 CRH GNAS POMC PRL SST
2
Cushing syndrome 37
Show member pathways
 11.84 CRH GNAS POMC
3
G alpha (s) signalling events 66
11.5 CRH GNAS POMC
4
Glucocorticoid receptor regulatory network 1
11.32 POMC PRL
5
Long-term depression 37
11.15 CRH GNAS
6
Corticotropin-releasing hormone signaling pathway 1
11.1 CRH GNAS POMC
7
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
9.47 CRH POMC
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GO Terms for Pituitary Carcinoma

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Cellular components related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 CHGA CRH POMC PRL SST
2 extracellular region GO:0005576 9.43 CHGA CRH GNAS POMC PRL SST
3 secretory granule GO:0030141 8.8 CHGA POMC PRL

Biological processes related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.71 CRH GNAS POMC SST
2 regulation of signaling receptor activity GO:0010469 9.61 POMC PRL SST
3 regulation of blood pressure GO:0008217 9.37 CHGA POMC
4 female pregnancy GO:0007565 9.33 CRH GNAS PRL
5 positive regulation of cAMP-mediated signaling GO:0043950 9.32 CRH GNAS
6 parturition GO:0007567 9.26 CRH PRL
7 hormone-mediated apoptotic signaling pathway GO:0008628 8.96 CRH SST
8 response to drug GO:0042493 8.92 CRH GNAS PRL SST

Molecular functions related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.16 GNAS POMC
2 corticotropin-releasing hormone receptor 1 binding GO:0051430 8.96 CRH GNAS
3 hormone activity GO:0005179 8.92 CRH POMC PRL SST
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Sources for Pituitary Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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