MCID: PTT010
MIFTS: 30

Pituitary Infarct

Categories: Endocrine diseases
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Aliases & Classifications for Pituitary Infarct

MalaCards integrated aliases for Pituitary Infarct:

Name: Pituitary Infarct 11 14
Pituitary Infarction 11 71

Classifications:



External Ids:

Disease Ontology 11 DOID:1130
NCIt 49 C27117
SNOMED-CT 68 95830009
UMLS 71 C0342405

Summaries for Pituitary Infarct

MalaCards based summary: Pituitary Infarct, also known as pituitary infarction, is related to premature ovarian failure 7 and central diabetes insipidus. An important gene associated with Pituitary Infarct is POMC (Proopiomelanocortin), and among its related pathways/superpathways are GPCR downstream signalling and Signal Transduction. Affiliated tissues include pituitary, hypothalamus and thyroid, and related phenotypes are nervous system and homeostasis/metabolism

Related Diseases for Pituitary Infarct

Diseases related to Pituitary Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 premature ovarian failure 7 30.2 POMC CRH
2 central diabetes insipidus 29.7 TRH PRL POMC IGF1 AVP
3 empty sella syndrome 29.6 TRH PRL POMC INS IGF1
4 pituitary tumors 29.6 SST PRL MEN1 IGF1
5 hypogonadism 29.5 PRL POMC INS IGF1
6 peptic ulcer disease 29.5 SST MEN1 INS
7 diabetes insipidus 29.4 PRL POMC INS CRH AVP
8 pituitary hormone deficiency, combined, 2 29.2 TRH PRL POMC IGF1 GHRH AVP
9 acth deficiency, isolated 28.9 TRH TBX19 PRL POMC CRH
10 sheehan syndrome 28.7 TRH PRL POMC INS IGF1 CRH
11 pituitary apoplexy 28.5 TRH SST PRL POMC INS IGF1
12 adenoma 28.5 TRH SST PRL POMC MEN1 IGF1
13 pituitary adenoma 28.5 TRH SST PRL POMC MEN1 IGF1
14 hypopituitarism 28.4 TRH TBX19 PRL POMC INS IGF1
15 hypoglycemia 28.3 TRH SST PRL POMC INS IGF1
16 acromegaly 27.6 TRH SST PRL POMC MEN1 INS
17 pituitary gland disease 26.4 TRH TBX19 SST PRL POMC MEN1
18 galactorrhea 10.3 PRL IGF1
19 abducens palsy 10.3 PRL POMC
20 sphenoid sinusitis 10.3 POMC AVP
21 gaba aminotransferase deficiency 10.3 POMC AVP
22 bronchial adenomas/carcinoids childhood 10.3 SST POMC
23 tuberculous epididymitis 10.3 POMC AVP
24 telogen effluvium 10.3 PRL IGF1
25 lung oat cell carcinoma 10.3 POMC AVP
26 partial third-nerve palsy 10.3 PRL POMC
27 malignant olfactory nerve neoplasm 10.3 POMC AVP
28 thyroid dyshormonogenesis 2a 10.2 SST POMC
29 diabetes insipidus, neurohypophyseal 10.2 POMC AVP
30 van maldergem syndrome 1 10.2 PRL POMC
31 endometrial small cell carcinoma 10.2 SST AVP
32 intracranial hypertension, idiopathic 10.2 POMC IGF1
33 autonomic nervous system benign neoplasm 10.2 SST POMC
34 null pituitary adenoma 10.2 MEN1 AIP
35 silent pituitary adenoma 10.2 MEN1 AIP
36 peripheral nervous system benign neoplasm 10.2 SST POMC
37 hypothyroidism, central, with testicular enlargement 10.2 TRH PRL
38 central precocious puberty 10.2 POMC IGF1
39 hypothyroidism, congenital, nongoitrous, 4 10.2 PRL POMC IGF1
40 cranial nerve palsy 10.2 PRL POMC AVP
41 waterhouse-friderichsen syndrome 10.2 POMC CRH
42 mediastinal lipomatosis 10.2 POMC CRH
43 cavernous sinus thrombosis 10.2 POMC INS
44 thyroid hormone resistance, selective pituitary 10.2 TRH SST
45 scleredema adultorum 10.2 POMC INS
46 factitious disorder 10.2 POMC INS
47 hirata disease 10.2 POMC INS
48 euthyroid sick syndrome 10.2 TRH POMC
49 non-functioning pancreatic endocrine tumor 10.2 SST MEN1
50 chiasmal syndrome 10.2 SST PRL POMC

Graphical network of the top 20 diseases related to Pituitary Infarct:



Diseases related to Pituitary Infarct

Symptoms & Phenotypes for Pituitary Infarct

MGI Mouse Phenotypes related to Pituitary Infarct:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.2 AVP CRH GHRH IGF1 INS MEN1
2 homeostasis/metabolism MP:0005376 10.15 AIP AVP CRH GHRH IGF1 INS
3 growth/size/body region MP:0005378 10.02 AIP CRH GHRH IGF1 INS MEN1
4 liver/biliary system MP:0005370 9.98 AIP CRH GHRH INS MEN1 POMC
5 endocrine/exocrine gland MP:0005379 9.96 AIP CRH GHRH IGF1 INS MEN1
6 no phenotypic analysis MP:0003012 9.95 AVP CRH INS POMC SST TRH
7 adipose tissue MP:0005375 9.88 CRH GHRH IGF1 INS POMC SST
8 behavior/neurological MP:0005386 9.85 AVP CRH GHRH GPR101 INS MEN1
9 immune system MP:0005387 9.61 AVP CRH GHRH IGF1 INS MEN1
10 integument MP:0010771 9.17 AIP CRH IGF1 INS POMC PRL

Drugs & Therapeutics for Pituitary Infarct

Search Clinical Trials, NIH Clinical Center for Pituitary Infarct

Genetic Tests for Pituitary Infarct

Anatomical Context for Pituitary Infarct

Organs/tissues related to Pituitary Infarct:

MalaCards : Pituitary, Hypothalamus, Thyroid, Brain

Publications for Pituitary Infarct

Articles related to Pituitary Infarct:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Coronavirus Disease 2019 and Pituitary Apoplexy: A Single-Center Case Series and Review of the Literature. 62
34129968 2021
2
Sheehan Syndrome: An Unusual Presentation Without Inciting Factors. 62
33786491 2020
3
CENTRAL HYPOTHYROIDISM IN SEVERE SEPSIS. 62
32010358 2019
4
Sudden Headache and Blindness Due to Pituitary (Adenoma) Infarction: A Case Report. 62
31016086 2019
5
Uncontrolled diabetes as a rare presenting cause of pituitary apoplexy. 62
30824466 2019
6
Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome. 62
29463076 2018
7
[Spontaneous remission of acromegaly and Cushing's disease in older patients. Report of two cases]. 62
30534895 2018
8
Hypopituitarism in a Dengue Shock Syndrome Survivor without known Pituitary Adenoma. 62
33579071 2016
9
Lesson of the month 2: Houssay phenomenon - hypopitutarism leading to remission of diabetes. 62
27251924 2016
10
Complete pituitary infarction associated with hypothermia and brain death. 62
26971812 2016
11
Pituitary Infarct Masquerading as a Pituitary Abscess. 62
26243170 2015
12
Silent pituitary infarction of an uncommon etiology. 62
25554633 2015
13
Sheehan syndrome: acute presentation with severe headache. 62
25223643 2014
14
A rare case of pituitary infarction leading to spontaneous tumour resolution and CSF-sella syndrome in an 11-year-old girl and a review of the paediatric literature. 62
24859515 2014
15
Acute Sheehan's syndrome presenting as central diabetes insipidus. 62
23131607 2012
16
Association of dengue hemorrhagic fever with multiple risk factors for pituitary apoplexy. 62
22297060 2012
17
Acute hypopituitarism in a pregnant patient after cardiac gunshot injury. 62
21741812 2011
18
Pituitary infarction: a potentially fatal cause of postoperative hyponatraemia and ocular palsy. 62
21415109 2011
19
Factors affecting the development of hypothalamus and pituitary lesions in fatal closed head injury: a prospective study. 62
20016386 2010
20
Pituitary apoplexy presenting as isolated third cranial nerve palsy with ptosis : two case reports. 62
19274125 2009
21
Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction. 62
18173320 2008
22
Silent pituitary infarction after coronary artery bypass grafting procedure: case report and review of literature. 62
16524865 2006
23
Apoplexy in pituitary macroadenoma: eight patients presenting in 12 months. 62
15879908 2005
24
Pituitary infarction resulting from intranasal cocaine abuse. 62
16033719 2004
25
Pituitary apoplexy: early detection with diffusion-weighted MR imaging. 62
12169486 2002
26
[Post-partum autoimmune thyroiditis in a patient presenting with Sheehan's syndrome]. 62
12193878 2002
27
Hypopituitarism after surgical clipping of a ruptured cerebral aneurysm. 62
11700429 2001
28
Sudden headache with pituitary infarction. 62
10595776 1999
29
Amelioration of acromegaly after pituitary infarction due to gastrointestinal hemorrhage from gastric ulcer. 62
10426579 1999
30
Postpartum psychosis in a case of sheehan's syndrome. 62
21455357 1999
31
Postpartum thyroid dysfunction. 62
9103952 1997
32
Case report: postpartum hypopituitarism in a patient with sickle cell trait. 62
8010335 1994
33
Effect of growth hormone and insulin-like growth factor I on urinary albumin excretion: studies in acromegaly and growth hormone deficiency. 62
8372600 1993
34
Elevated plasma adrenocorticotropin (ACTH) with adrenal hyperplasia: a new factor in ACTH regulation? 62
1653782 1991
35
Snake venoms in science and clinical medicine. 1. Russell's viper: biology, venom and treatment of bites. 62
2533418 1989
36
Antepartum pituitary necrosis in diabetes mellitus. 62
2967155 1988
37
Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction. 62
2845379 1988
38
Infarction of a growth hormone-secreting macroadenoma during a TRH test. 62
3090811 1986
39
Pituitary apoplexy. A review. 62
4015472 1985
40
The effect of dopamine agonist therapy on large functionless pituitary tumours. 62
4028461 1985
41
Isolated adrenocorticotropic hormone deficiency with antepartum pituitary infarction in a type I diabetic. 62
2983276 1985
42
Growth hormone secretion in the fetal sheep following stereotaxic electrolytic lesioning of the fetal hypothalamus. 62
3920303 1985
43
Pituitary infarction and development of the empty sella syndrome after gastrointestinal haemorrhage. 62
6434032 1984
44
Sheehan's syndrome: in vivo diagnosis with the use of computerized axial tomography and pituitary provocative testing. 62
6319203 1984
45
Severe diabetic microangiopathy with normal glucose tolerance and pituitary infarction. 62
6414614 1983
46
Antepartum pituitary infarction. 62
424120 1979
47
Pituitary stalk-section and some of its effects on endocrine function in the fetal lamb. 62
250110 1978
48
Pregnancy in a case of Nelson's syndrome. 62
696256 1978
49
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. 62
890301 1977
50
Pituitary abscess. 62
865667 1977

Variations for Pituitary Infarct

Expression for Pituitary Infarct

Search GEO for disease gene expression data for Pituitary Infarct.

Pathways for Pituitary Infarct

Pathways related to Pituitary Infarct according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 TRH SST POMC GHRH CRH AVP
2 13.02 TRH SST POMC MEN1 INS IGF1
3
Show member pathways
13.01 TRH SST POMC GHRH CRH AVP
4
Show member pathways
11.84 POMC INS IGF1
5
Show member pathways
11.66 POMC GHRH CRH AVP
6 11.5 CRH POMC TBX19
7 11.21 POMC INS GHRH
8
Show member pathways
10.97 TRH POMC
9
Show member pathways
10.92 POMC CRH
10 10.17 POMC CRH
11 10.1 PRL POMC INS

GO Terms for Pituitary Infarct

Cellular components related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 SST PRL POMC INS IGF1 GHRH
2 extracellular region GO:0005576 9.58 TRH SST PRL POMC INS IGF1

Biological processes related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell population proliferation GO:0008284 9.85 PRL INS IGF1 GHRH AVP
2 signal transduction GO:0007165 9.77 AVP CRH GPR101 IGF1 INS POMC
3 positive regulation of glycogen biosynthetic process GO:0045725 9.62 INS IGF1
4 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.56 IGF1 GHRH
5 cell-cell signaling GO:0007267 9.4 TRH SST POMC INS GHRH AVP

Molecular functions related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.5 TRH SST PRL POMC INS IGF1
2 neuropeptide hormone activity GO:0005184 9.43 GHRH CRH AVP

Sources for Pituitary Infarct

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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