Pituitary Infarct disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pituitary Infarct

MalaCards integrated aliases for Pituitary Infarct:

Name: Pituitary Infarct ¹² ¹⁵

Pituitary Infarction ¹² ⁷³

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1130

NCIt ⁵⁰ C27117

SNOMED-CT ⁶⁸ 95830009

UMLS ⁷³ C0342405

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Summaries for Pituitary Infarct

MalaCards based summary : Pituitary Infarct, also known as pituitary infarction, is related to diabetes insipidus and acromegaly. An important gene associated with Pituitary Infarct is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Glucocorticoid receptor regulatory network. Affiliated tissues include pituitary, and related phenotypes are homeostasis/metabolism and immune system

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Related Diseases for Pituitary Infarct

Diseases related to Pituitary Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes insipidus	29.6	POMC PRL
2	acromegaly	27.9	IGF1 POMC PRL SST
3	empty sella syndrome	27.5	GNRH1 IGF1 POMC PRL
4	adenohypophysitis	10.3	POMC PRL
5	sella turcica neoplasm	10.3	POMC PRL
6	tuberculum sellae meningioma	10.3	POMC PRL
7	acth-secreting pituitary adenoma	10.2	POMC PRL
8	fasting hypoglycemia	10.2	IGF1 POMC
9	galactorrhea	10.2	IGF1 PRL
10	persistent fetal circulation syndrome	10.2	IGF1 POMC
11	pseudohypoparathyroidism, type ia	10.2	IGF1 PRL
12	bronchus adenoma	10.2	POMC SST
13	opiate dependence	10.2	IGF1 POMC
14	gynecomastia	10.2	POMC PRL
15	mammographic density	10.2	IGF1 PRL
16	ectopic cushing syndrome	10.1	POMC SST
17	tsh producing pituitary tumor	10.1	PRL SST
18	acanthosis nigricans	10.1	IGF1 PRL
19	chronic fatigue syndrome	10.1	IGF1 POMC
20	hormone producing pituitary cancer	10.1	IGF1 SST
21	prolactin producing pituitary tumor	10.1	PRL SST
22	overnutrition	10.0	IGF1 POMC
23	growth hormone secreting pituitary adenoma	10.0	PRL SST
24	carcinoid syndrome	10.0	IGF1 SST
25	breast disease	10.0	IGF1 PRL
26	short bowel syndrome	10.0	IGF1 SST
27	microvascular complications of diabetes 1	10.0	IGF1 SST
28	endometriosis of uterus	9.9	GNRH1 PRL
29	adrenal rest tumor	9.9	GNRH1 POMC
30	hypogonadotropism	9.9	GNRH1 PRL
31	endogenous depression	9.8	GNRH1 POMC
32	insulin-like growth factor i	9.8	IGF1 PRL
33	central precocious puberty	9.8	GNRH1 IGF1
34	hyperthyroidism	9.8	PRL SST
35	multiple endocrine neoplasia, type i	9.8	PRL SST
36	sheehan syndrome	9.7	IGF1 POMC PRL
37	hypothyroidism, congenital, nongoitrous, 4	9.7	IGF1 POMC PRL
38	thyroid carcinoma, familial medullary	9.7	POMC SST
39	central nervous system organ benign neoplasm	9.7	IGF1 POMC PRL
40	varicocele	9.7	GNRH1 PRL
41	pituitary hormone deficiency, combined, 2	9.7	IGF1 POMC PRL
42	thyroid gland disease	9.7	IGF1 POMC PRL
43	robinow syndrome	9.7	GNRH1 IGF1
44	anorexia nervosa	9.7	IGF1 POMC PRL
45	male reproductive organ cancer	9.7	GNRH1 IGF1
46	reproductive system disease	9.7	GNRH1 PRL
47	acidophil adenoma	9.6	IGF1 POMC SST
48	hypothyroidism	9.6	IGF1 POMC PRL
49	pituitary carcinoma	9.6	POMC PRL SST
50	nelson syndrome	9.6	POMC PRL SST

Graphical network of the top 20 diseases related to Pituitary Infarct:

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Symptoms & Phenotypes for Pituitary Infarct

MGI Mouse Phenotypes related to Pituitary Infarct:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.72	GNRH1 IGF1 POMC PRL SST
2	immune system	MP:0005387	9.65	GNRH1 IGF1 POMC PRL SST
3	integument	MP:0010771	9.46	GNRH1 IGF1 POMC PRL
4	neoplasm	MP:0002006	9.26	GNRH1 IGF1 POMC PRL
5	nervous system	MP:0003631	9.02	GNRH1 IGF1 POMC PRL SST

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Drugs & Therapeutics for Pituitary Infarct

Search Clinical Trials , NIH Clinical Center for Pituitary Infarct

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Genetic Tests for Pituitary Infarct

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Anatomical Context for Pituitary Infarct

MalaCards organs/tissues related to Pituitary Infarct:

⁴¹

Pituitary

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Publications for Pituitary Infarct

Articles related to Pituitary Infarct:

#	Title	Authors	Year
1	Pituitary Infarct Masquerading as a Pituitary Abscess. ( 26243170 )	Choi H.S....Hong Y.K.	2015
2	Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction. ( 18173320 )	Salehi F....Scheithauer B.W.	2008
3	Pituitary infarction resulting from intranasal cocaine abuse. ( 16033719 )	Insel J.R....Dhanjal N.	2004
4	Pituitary infarction and development of the empty sella syndrome after gastrointestinal haemorrhage. ( 6434032 )	Jones N.S....Finer N.	1984
5	Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. ( 890301 )	Brooks M.R....Heath D.A.	1977

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Genes for Pituitary Infarct

Genes related to Pituitary Infarct (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POMC	Proopiomelanocortin	Protein Coding	17.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PRL	Prolactin	Protein Coding	15.69	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	SST	Somatostatin	Protein Coding	14.81	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	14.79	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	IGF1	Insulin Like Growth Factor 1	Protein Coding	14.75	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Pituitary Infarct

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Expression for Pituitary Infarct

Search GEO for disease gene expression data for Pituitary Infarct.

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Pathways for Pituitary Infarct

Pathways related to Pituitary Infarct according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶⁶ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁶ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁶ G alpha (i) signalling events ⁶⁶ GPCR ligand binding ⁶⁶ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁷ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁶ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁶ Vasopressin-like receptors ⁶⁶	12.52	GNRH1 POMC PRL SST
2	Glucocorticoid receptor regulatory network ¹	10.54	POMC PRL

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GO Terms for Pituitary Infarct

Cellular components related to Pituitary Infarct according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.35	GNRH1 IGF1 POMC PRL SST
2	extracellular space	GO:0005615	9.02	GNRH1 IGF1 POMC PRL SST

Biological processes related to Pituitary Infarct according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glucose homeostasis	GO:0042593	9.43	IGF1 POMC
2	cell-cell signaling	GO:0007267	9.43	GNRH1 POMC SST
3	female pregnancy	GO:0007565	9.4	GNRH1 PRL
4	response to nutrient levels	GO:0031667	9.37	IGF1 PRL
5	response to heat	GO:0009408	9.32	IGF1 SST
6	response to steroid hormone	GO:0048545	9.16	GNRH1 SST
7	regulation of signaling receptor activity	GO:0010469	9.02	GNRH1 IGF1 POMC PRL SST
8	regulation of multicellular organism growth	GO:0040014	8.96	IGF1 PRL

Molecular functions related to Pituitary Infarct according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.02	GNRH1 IGF1 POMC PRL SST

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