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MCID: PTT010
MIFTS: 32

Pituitary Infarct

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Pituitary Infarct

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MalaCards integrated aliases for Pituitary Infarct:

Name: Pituitary Infarct 12 15
Pituitary Infarction 12 70

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1130
NCIt 50 C27117
SNOMED-CT 67 95830009
UMLS 70 C0342405
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Summaries for Pituitary Infarct

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MalaCards based summary : Pituitary Infarct, also known as pituitary infarction, is related to hypogonadism and acth deficiency, isolated. An important gene associated with Pituitary Infarct is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include pituitary, thyroid and cortex, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

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Related Diseases for Pituitary Infarct

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Diseases related to Pituitary Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 hypogonadism 29.2 PRL INS IGF1 GNRH1
2 acth deficiency, isolated 29.1 TRH PRL POMC CRH
3 pituitary tumors 29.0 SST PRL POMC MEN1 IGF1 AIP
4 diabetes insipidus 29.0 PRL POMC INS CRH AVP
5 pituitary hormone deficiency, combined, 2 29.0 TRH PRL POMC IGF1 GHRH AVP
6 empty sella syndrome 28.9 TRH PRL POMC INS IGF1 GNRH1
7 hypoglycemia 28.5 SST PRL POMC INS IGF1 CRH
8 hypothyroidism 28.0 TRH SST PRL POMC INS IGF1
9 adenoma 28.0 TRH SST PRL POMC MEN1 IGF1
10 hypopituitarism 27.9 TRH PRL POMC INS IGF1 GNRH1
11 pituitary apoplexy 27.9 SST PRL POMC MEN1 INS IGF1
12 pituitary adenoma 27.6 TRH SST PRL POMC MEN1 IGF1
13 acromegaly 27.0 TRH SST PRL POMC MEN1 INS
14 abducens nerve disease 10.3 PRL POMC
15 galactorrhea 10.3 PRL IGF1
16 hypothyroidism, congenital, nongoitrous, 4 10.3 PRL POMC
17 tuberculous epididymitis 10.3 POMC AVP
18 bronchial adenomas/carcinoids childhood 10.3 SST POMC
19 chiasmal syndrome 10.3 SST POMC
20 olfactory nerve neoplasm 10.3 POMC AVP
21 cranial nerve malignant neoplasm 10.3 POMC AVP
22 partial third-nerve palsy 10.3 PRL IGF1
23 anterior cerebral artery infarction 10.3 PRL AVP
24 colon neuroendocrine neoplasm 10.3 SST POMC
25 cranial nerve neoplasm 10.3 POMC AVP
26 glutamate-cysteine ligase deficiency 10.2 PRL AVP
27 intracranial hypertension, idiopathic 10.2 POMC IGF1
28 myxedema 10.2 POMC AVP
29 null pituitary adenoma 10.2 MEN1 AIP
30 silent pituitary adenoma 10.2 MEN1 AIP
31 isolated growth hormone deficiency type iii 10.2 IGF1 GHRH
32 generalized resistance to thyroid hormone 10.2 TRH PRL
33 premenstrual tension 10.2 POMC GNRH1
34 haemophilus meningitis 10.2 SST AVP
35 familial isolated pituitary adenoma 10.2 MEN1 AIP
36 pyometritis 10.2 PRL GNRH1
37 gastrointestinal neuroendocrine benign tumor 10.2 SST MEN1
38 cranial nerve palsy 10.2 PRL POMC AVP
39 non-functioning pancreatic endocrine tumor 10.2 SST MEN1
40 duodenal gastrinoma 10.2 SST MEN1
41 gastric neuroendocrine neoplasm 10.2 SST MEN1
42 hypothyroidism, central, with testicular enlargement 10.2 TRH PRL
43 pancreatic gastrinoma 10.2 SST MEN1
44 gastrointestinal neuroendocrine tumor 10.2 SST MEN1
45 carcinoid tumors, intestinal 10.2 SST MEN1
46 small intestine neuroendocrine neoplasm 10.2 SST MEN1
47 lung oat cell carcinoma 10.2 POMC AVP
48 central precocious puberty 10.2 IGF1 GNRH1
49 tsh producing pituitary tumor 10.2 SST PRL POMC
50 small intestine benign neoplasm 10.2 SST MEN1

Graphical network of the top 20 diseases related to Pituitary Infarct:



Diseases related to Pituitary Infarct
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Symptoms & Phenotypes for Pituitary Infarct

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MGI Mouse Phenotypes related to Pituitary Infarct:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.23 AIP AVP CRH GHRH GNRH1 IGF1
2 endocrine/exocrine gland MP:0005379 10.19 AIP CRH GHRH GNRH1 IGF1 INS
3 growth/size/body region MP:0005378 10.18 AIP CRH GHRH GNRH1 IGF1 INS
4 immune system MP:0005387 10.13 AVP CRH GHRH GNRH1 IGF1 INS
5 nervous system MP:0003631 10 AVP CRH GHRH GNRH1 IGF1 INS
6 adipose tissue MP:0005375 9.99 CRH GHRH IGF1 INS POMC SST
7 liver/biliary system MP:0005370 9.97 AIP CRH GHRH GNRH1 INS MEN1
8 integument MP:0010771 9.95 AIP CRH GNRH1 IGF1 INS POMC
9 neoplasm MP:0002006 9.8 AIP GNRH1 IGF1 MEN1 POMC PRL
10 no phenotypic analysis MP:0003012 9.63 AVP CRH INS POMC SST TRH
11 renal/urinary system MP:0005367 9.5 AVP CRH GNRH1 IGF1 INS POMC
12 skeleton MP:0005390 9.17 CRH GHRH GNRH1 IGF1 INS SST
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Drugs & Therapeutics for Pituitary Infarct

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Search Clinical Trials , NIH Clinical Center for Pituitary Infarct

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Genetic Tests for Pituitary Infarct

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Anatomical Context for Pituitary Infarct

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MalaCards organs/tissues related to Pituitary Infarct:

40
Pituitary, Thyroid, Cortex, Small Intestine, Kidney, Lung, Ovary
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Publications for Pituitary Infarct

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Articles related to Pituitary Infarct:

(show top 50) (show all 52)
# Title Authors PMID Year
1
Sheehan Syndrome: An Unusual Presentation Without Inciting Factors. 61
33786491 2020
2
CENTRAL HYPOTHYROIDISM IN SEVERE SEPSIS. 61
32010358 2019
3
Sudden Headache and Blindness Due to Pituitary (Adenoma) Infarction: A Case Report. 61
31016086 2019
4
Uncontrolled diabetes as a rare presenting cause of pituitary apoplexy. 61
30824466 2019
5
Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome. 61
29463076 2018
6
[Spontaneous remission of acromegaly and Cushing's disease in older patients. Report of two cases]. 61
30534895 2018
7
Hypopituitarism in a Dengue Shock Syndrome Survivor without known Pituitary Adenoma. 61
33579071 2016
8
Lesson of the month 2: Houssay phenomenon - hypopitutarism leading to remission of diabetes. 61
27251924 2016
9
Complete pituitary infarction associated with hypothermia and brain death. 61
26971812 2016
10
Pituitary Infarct Masquerading as a Pituitary Abscess. 61
26243170 2015
11
Silent pituitary infarction of an uncommon etiology. 61
25554633 2015
12
Sheehan syndrome: acute presentation with severe headache. 61
25223643 2014
13
A rare case of pituitary infarction leading to spontaneous tumour resolution and CSF-sella syndrome in an 11-year-old girl and a review of the paediatric literature. 61
24859515 2014
14
Acute Sheehan's syndrome presenting as central diabetes insipidus. 61
23131607 2012
15
Association of dengue hemorrhagic fever with multiple risk factors for pituitary apoplexy. 61
22297060 2012
16
Acute hypopituitarism in a pregnant patient after cardiac gunshot injury. 61
21741812 2011
17
Pituitary infarction: a potentially fatal cause of postoperative hyponatraemia and ocular palsy. 61
21415109 2011
18
Factors affecting the development of hypothalamus and pituitary lesions in fatal closed head injury: a prospective study. 61
20016386 2010
19
Pituitary apoplexy presenting as isolated third cranial nerve palsy with ptosis : two case reports. 61
19274125 2009
20
Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction. 61
18173320 2008
21
Silent pituitary infarction after coronary artery bypass grafting procedure: case report and review of literature. 61
16524865 2006
22
Apoplexy in pituitary macroadenoma: eight patients presenting in 12 months. 61
15879908 2005
23
Pituitary infarction resulting from intranasal cocaine abuse. 61
16033719 2004
24
Pituitary apoplexy: early detection with diffusion-weighted MR imaging. 61
12169486 2002
25
[Post-partum autoimmune thyroiditis in a patient presenting with Sheehan's syndrome]. 61
12193878 2002
26
Hypopituitarism after surgical clipping of a ruptured cerebral aneurysm. 61
11700429 2001
27
Sudden headache with pituitary infarction. 61
10595776 1999
28
Amelioration of acromegaly after pituitary infarction due to gastrointestinal hemorrhage from gastric ulcer. 61
10426579 1999
29
Postpartum psychosis in a case of sheehan's syndrome. 61
21455357 1999
30
Postpartum thyroid dysfunction. 61
9103952 1997
31
Case report: postpartum hypopituitarism in a patient with sickle cell trait. 61
8010335 1994
32
Effect of growth hormone and insulin-like growth factor I on urinary albumin excretion: studies in acromegaly and growth hormone deficiency. 61
8372600 1993
33
Elevated plasma adrenocorticotropin (ACTH) with adrenal hyperplasia: a new factor in ACTH regulation? 61
1653782 1991
34
Snake venoms in science and clinical medicine. 1. Russell's viper: biology, venom and treatment of bites. 61
2533418 1989
35
Antepartum pituitary necrosis in diabetes mellitus. 61
2967155 1988
36
Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction. 61
2845379 1988
37
Infarction of a growth hormone-secreting macroadenoma during a TRH test. 61
3090811 1986
38
Pituitary apoplexy. A review. 61
4015472 1985
39
The effect of dopamine agonist therapy on large functionless pituitary tumours. 61
4028461 1985
40
Isolated adrenocorticotropic hormone deficiency with antepartum pituitary infarction in a type I diabetic. 61
2983276 1985
41
Growth hormone secretion in the fetal sheep following stereotaxic electrolytic lesioning of the fetal hypothalamus. 61
3920303 1985
42
Pituitary infarction and development of the empty sella syndrome after gastrointestinal haemorrhage. 61
6434032 1984
43
Sheehan's syndrome: in vivo diagnosis with the use of computerized axial tomography and pituitary provocative testing. 61
6319203 1984
44
Severe diabetic microangiopathy with normal glucose tolerance and pituitary infarction. 61
6414614 1983
45
Antepartum pituitary infarction. 61
424120 1979
46
Pituitary stalk-section and some of its effects on endocrine function in the fetal lamb. 61
250110 1978
47
Pregnancy in a case of Nelson's syndrome. 61
696256 1978
48
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. 61
890301 1977
49
Pituitary abscess. 61
865667 1977
50
Renal cortical necrosis with pituitary infarction in a nonpregnant woman. 61
5689121 1968
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Variations for Pituitary Infarct

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Expression for Pituitary Infarct

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Search GEO for disease gene expression data for Pituitary Infarct.
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Pathways for Pituitary Infarct

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Pathways related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 13.65 TRH SST POMC MEN1 INS IGF1
2
Peptide ligand-binding receptors 65
Show member pathways
 12.84 TRH SST PRL POMC GNRH1 GHRH
3
Aldosterone synthesis and secretion 36
Show member pathways
 12.49 POMC MEN1 INS CRH AIP
4
Peptide hormone metabolism 65
Show member pathways
 11.84 POMC INS IGF1
5
G alpha (s) signalling events 65
11.62 POMC GHRH CRH AVP
6
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 10.91 TRH POMC
7
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10.21 POMC CRH
8
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.1 PRL POMC INS
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GO Terms for Pituitary Infarct

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Cellular components related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SST PRL POMC INS IGF1 GNRH1
2 perikaryon GO:0043204 9.5 GNRH1 GHRH CRH
3 secretory granule GO:0030141 9.33 TRH POMC AVP
4 extracellular region GO:0005576 9.32 TRH SST PRL POMC INS IGF1
5 endosome lumen GO:0031904 9.26 PRL INS

Biological processes related to Pituitary Infarct according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.92 TRH PRL POMC INS IGF1 GNRH1
2 positive regulation of gene expression GO:0010628 9.86 INS IGF1 CRH AVP
3 cellular protein metabolic process GO:0044267 9.71 PRL MEN1 INS IGF1
4 response to organic cyclic compound GO:0014070 9.69 TRH GNRH1 AVP
5 female pregnancy GO:0007565 9.63 PRL GNRH1 CRH
6 positive regulation of cell proliferation GO:0008284 9.63 PRL INS IGF1 GHRH CRH AVP
7 positive regulation of mitotic nuclear division GO:0045840 9.58 INS IGF1
8 regulation of multicellular organism growth GO:0040014 9.57 PRL IGF1
9 response to ethanol GO:0045471 9.56 TRH GNRH1 CRH AVP
10 G protein-coupled receptor signaling pathway GO:0007186 9.56 TRH SST POMC INS GNRH1 GHRH
11 positive regulation of glycolytic process GO:0045821 9.55 INS IGF1
12 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.54 IGF1 AVP
13 response to corticosterone GO:0051412 9.52 TRH CRH
14 positive regulation of glycogen biosynthetic process GO:0045725 9.49 INS IGF1
15 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.48 IGF1 GHRH
16 negative regulation of feeding behavior GO:2000252 9.43 TRH INS
17 hormone-mediated apoptotic signaling pathway GO:0008628 9.37 SST CRH
18 cell-cell signaling GO:0007267 9.17 TRH SST POMC INS GNRH1 GHRH

Molecular functions related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.32 TRH SST PRL POMC INS IGF1
2 insulin receptor binding GO:0005158 9.26 INS IGF1
3 insulin-like growth factor receptor binding GO:0005159 9.16 INS IGF1
4 neuropeptide hormone activity GO:0005184 9.13 GHRH CRH AVP
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Sources for Pituitary Infarct

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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