MCID: PTT010
MIFTS: 28

Pituitary Infarct

Categories: Endocrine diseases

Aliases & Classifications for Pituitary Infarct

MalaCards integrated aliases for Pituitary Infarct:

Name: Pituitary Infarct 12 15
Pituitary Infarction 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1130
NCIt 51 C27117
SNOMED-CT 69 95830009
UMLS 74 C0342405

Summaries for Pituitary Infarct

MalaCards based summary : Pituitary Infarct, also known as pituitary infarction, is related to diabetes insipidus and acromegaly. An important gene associated with Pituitary Infarct is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Glucocorticoid receptor regulatory network. Affiliated tissues include pituitary and brain, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Pituitary Infarct

Diseases related to Pituitary Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 diabetes insipidus 29.8 POMC PRL
2 acromegaly 28.9 IGF1 POMC PRL SST
3 empty sella syndrome 28.8 GNRH1 IGF1 POMC PRL
4 adenohypophysitis 10.1 POMC PRL
5 sella turcica neoplasm 10.1 POMC PRL
6 tuberculum sellae meningioma 10.1 POMC PRL
7 acth-secreting pituitary adenoma 10.1 POMC PRL
8 abducens nerve disease 10.1 POMC PRL
9 hypogonadotropism 10.1 GNRH1 PRL
10 pelvic varices 10.1 GNRH1 PRL
11 gynecomastia 10.1 POMC PRL
12 fasting hypoglycemia 10.1 IGF1 POMC
13 galactorrhea 10.0 IGF1 PRL
14 pseudohypoparathyroidism, type ia 10.0 IGF1 PRL
15 adenomyosis 10.0 GNRH1 PRL
16 central precocious puberty 10.0 GNRH1 IGF1
17 varicocele 10.0 GNRH1 PRL
18 opiate dependence 10.0 IGF1 POMC
19 mammographic density 10.0 IGF1 PRL
20 fibromyalgia 10.0 IGF1 PRL
21 female reproductive system disease 10.0 GNRH1 PRL
22 chronic fatigue syndrome 10.0 IGF1 POMC
23 bronchus adenoma 10.0 POMC SST
24 bronchial adenomas/carcinoids childhood 10.0 POMC SST
25 acanthosis nigricans 10.0 IGF1 PRL
26 overnutrition 10.0 IGF1 POMC
27 male reproductive organ cancer 10.0 GNRH1 IGF1
28 robinow syndrome 10.0 GNRH1 IGF1
29 pancreatic endocrine carcinoma 10.0 POMC SST
30 male reproductive system disease 9.9 GNRH1 IGF1
31 premature ovarian failure 1 9.9 GNRH1 PRL
32 ectopic cushing syndrome 9.9 POMC SST
33 prolactin producing pituitary tumor 9.9 PRL SST
34 adrenal gland disease 9.9 POMC SST
35 growth hormone secreting pituitary adenoma 9.9 PRL SST
36 spinocerebellar degeneration 9.9 PRL SST
37 hypothalamic disease 9.9 GNRH1 POMC PRL
38 pituitary apoplexy 9.9 GNRH1 POMC PRL
39 diabetes insipidus, neurohypophyseal 9.9 GNRH1 POMC PRL
40 hormone producing pituitary cancer 9.9 IGF1 SST
41 premenstrual tension 9.9 GNRH1 POMC PRL
42 chromophobe adenoma 9.9 GNRH1 POMC PRL
43 adrenal rest tumor 9.9 GNRH1 POMC PRL
44 amenorrhea 9.8 GNRH1 POMC PRL
45 carcinoid syndrome 9.8 IGF1 SST
46 endocrine pancreas disease 9.8 IGF1 SST
47 isolated growth hormone deficiency, type ii 9.8 IGF1 SST
48 sheehan syndrome 9.8 IGF1 POMC PRL
49 short bowel syndrome 9.8 IGF1 SST
50 hypothyroidism, congenital, nongoitrous, 4 9.8 IGF1 POMC PRL

Graphical network of the top 20 diseases related to Pituitary Infarct:



Diseases related to Pituitary Infarct

Symptoms & Phenotypes for Pituitary Infarct

MGI Mouse Phenotypes related to Pituitary Infarct:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.72 GNRH1 IGF1 POMC PRL SST
2 immune system MP:0005387 9.65 GNRH1 IGF1 POMC PRL SST
3 integument MP:0010771 9.46 GNRH1 IGF1 POMC PRL
4 neoplasm MP:0002006 9.26 GNRH1 IGF1 POMC PRL
5 nervous system MP:0003631 9.02 GNRH1 IGF1 POMC PRL SST

Drugs & Therapeutics for Pituitary Infarct

Search Clinical Trials , NIH Clinical Center for Pituitary Infarct

Genetic Tests for Pituitary Infarct

Anatomical Context for Pituitary Infarct

MalaCards organs/tissues related to Pituitary Infarct:

42
Pituitary, Brain

Publications for Pituitary Infarct

Articles related to Pituitary Infarct:

(show all 19)
# Title Authors Year
1
Complete pituitary infarction associated with hypothermia and brain death. ( 26971812 )
2016
2
Pituitary Infarct Masquerading as a Pituitary Abscess. ( 26243170 )
2015
3
Silent pituitary infarction of an uncommon etiology. ( 25554633 )
2015
4
A rare case of pituitary infarction leading to spontaneous tumour resolution and CSF-sella syndrome in an 11-year-old girl and a review of the paediatric literature. ( 24859515 )
2014
5
Pituitary infarction: a potentially fatal cause of postoperative hyponatraemia and ocular palsy. ( 21415109 )
2011
6
Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction. ( 18173320 )
2008
7
Silent pituitary infarction after coronary artery bypass grafting procedure: case report and review of literature. ( 16524865 )
2006
8
Pituitary infarction resulting from intranasal cocaine abuse. ( 16033719 )
2004
9
Amelioration of acromegaly after pituitary infarction due to gastrointestinal hemorrhage from gastric ulcer. ( 10426579 )
1999
10
Sudden headache with pituitary infarction. ( 10595776 )
1999
11
Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction. ( 2845379 )
1988
12
Isolated adrenocorticotropic hormone deficiency with antepartum pituitary infarction in a type I diabetic. ( 2983276 )
1985
13
Pituitary infarction and development of the empty sella syndrome after gastrointestinal haemorrhage. ( 6434032 )
1984
14
Severe diabetic microangiopathy with normal glucose tolerance and pituitary infarction. ( 6414614 )
1983
15
Antepartum pituitary infarction. ( 424120 )
1979
16
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. ( 890301 )
1977
17
Renal cortical necrosis with pituitary infarction in a nonpregnant woman. ( 5689121 )
1968
18
Amelioration of diabetes mellitus after pituitary infarction. Report of three cases. ( 13827343 )
1960
19
[Postpartum pituitary infarction; Sheehan's syndrome; report of three cases]. ( 13286786 )
1956

Variations for Pituitary Infarct

Expression for Pituitary Infarct

Search GEO for disease gene expression data for Pituitary Infarct.

Pathways for Pituitary Infarct

GO Terms for Pituitary Infarct

Cellular components related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 GNRH1 IGF1 POMC PRL SST
2 extracellular space GO:0005615 9.02 GNRH1 IGF1 POMC PRL SST
3 secretory granule GO:0030141 8.85 POMC

Biological processes related to Pituitary Infarct according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.46 GNRH1 PRL
2 response to heat GO:0009408 9.37 IGF1 SST
3 cell-cell signaling GO:0007267 9.33 GNRH1 POMC SST
4 response to steroid hormone GO:0048545 9.32 GNRH1 SST
5 regulation of multicellular organism growth GO:0040014 9.26 IGF1 PRL
6 response to organic cyclic compound GO:0014070 9.19 GNRH1
7 response to ethanol GO:0045471 9.18 GNRH1
8 response to nutrient GO:0007584 9.13 SST
9 positive regulation of epithelial cell proliferation GO:0050679 9.1 IGF1
10 regulation of signaling receptor activity GO:0010469 9.02 GNRH1 IGF1 POMC PRL SST
11 ovulation cycle GO:0042698 8.65 GNRH1

Molecular functions related to Pituitary Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GNRH1 IGF1 POMC PRL SST

Sources for Pituitary Infarct

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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