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MCID: PTT037
MIFTS: 44

Pituitary Tumors

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Pituitary Tumors

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MalaCards integrated aliases for Pituitary Tumors:

Name: Pituitary Tumors 53 54 42
Pituitary Neoplasms 70
Pituitary Tumor 58

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS via Orphanet 71 C0032019
Orphanet 58 ORPHA304055
UMLS 70 C0032019
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Summaries for Pituitary Tumors

About this section
NINDS : 53 The pituitary is a small, bean-sized gland that is below the hypothalamus, a structure at the base of the brain, by a thread-like stalk that contains both blood vessels and nerves.  It controls a system of hormones in the body that regulate growth, metabolism, the stress response, and functions of the sex organs via the thyroid gland, adrenal gland, ovaries, and testes.  A pituitary tumor is an abnormal growth of cells within the pituitary gland.  Most pituitary tumors are benign, which means they are non-cancerous, grow slowly and do not spread to other parts of the body; however they can make the pituitary gland produce either too many or too few hormones, which can cause problems in the body. Tumors that make hormones are called functioning tumors, and they can cause a wide array of symptoms depending upon the hormone affected.  Tumors that don’t make hormones are called non-functioning tumors.  Their symptoms are directly related to their growth in size and include headaches, vision problems, nausea, and vomiting.  Diseases related to hormone abnormalities include Cushing’s disease, in which fat builds up in the face, back and chest, and the arms and legs become very thin; and acromegaly, a condition in which the hands, feet, and face are larger than normal.  Pituitary hormones that impact the sex hormones, such as estrogen and testosterone, can make a woman produce breast milk even though she is not pregnant or nursing, or cause a man to lose his sex drive or lower his sperm count.  Pituitary tumors often go undiagnosed because their symptoms resemble those of so many other more common diseases.

MalaCards based summary : Pituitary Tumors, also known as pituitary neoplasms, is related to tsh producing pituitary tumor and empty sella syndrome. An important gene associated with Pituitary Tumors is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Aldosterone synthesis and secretion. The drugs Prednisone and Cefuroxime have been mentioned in the context of this disorder. Affiliated tissues include pituitary, hypothalamus and adrenal gland, and related phenotypes are endocrine/exocrine gland and growth/size/body region

MedlinePlus : 42 Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body. Pituitary tumors are common, but often they don't cause health problems. Most people with pituitary tumors never even know they have them. The most common type of pituitary tumor produces hormones and disrupts the balance of hormones in your body. This can cause endocrine diseases such as Cushing's syndrome and hyperthyroidism. Symptoms of pituitary tumors include Headaches Vision problems Nausea and vomiting Problems caused by the production of too many hormones Pituitary tumors are usually curable. Treatment is often surgery to remove the tumor. Other options include medicines, radiation therapy, and chemotherapy.

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Related Diseases for Pituitary Tumors

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Diseases related to Pituitary Tumors via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 460)
# Related Disease Score Top Affiliating Genes
1 tsh producing pituitary tumor 31.5 SSTR5 SST PRL POMC GH1
2 empty sella syndrome 31.2 PROP1 PRL POMC IGF1 GH1
3 familial isolated pituitary adenoma 31.1 MEN1 CNC2 AIP
4 pituitary adenoma 1, multiple types 31.0 SST PRL MEN1 IGF1 GH1 AIP
5 galactorrhea 31.0 PRL IGF1
6 diabetes insipidus 30.7 PRL POMC GH1
7 non-functioning pituitary adenoma 30.6 SST GH1
8 primary pigmented nodular adrenocortical disease 30.6 POMC MEN1 GNAS CNC2
9 amenorrhea 30.5 PRL POMC IGF1
10 hypopituitarism 30.2 PROP1 PRL POMC IGF1 GH1
11 chromophobe adenoma 30.2 PRL POMC GH1
12 gigantism 30.2 PRL GH1 AIP
13 hyperprolactinemia 30.2 SST PRL POMC IGF1 GNAS GH1
14 insulin-like growth factor i 30.1 SST PRL IGF1 GH1
15 craniopharyngioma 30.0 PTTG1 PROP1 PRL IGF1 GH1
16 hormone producing pituitary cancer 30.0 SSTR5 SST PRL POMC MEN1 IGF1
17 small cell cancer of the lung 29.9 SST RB1 POMC
18 dowling-degos disease 1 29.9 POMC GNAS
19 lymphocytic hypophysitis 29.9 POMC GH1
20 adenohypophysitis 29.9 PRL POMC GH1
21 chiasmal syndrome 29.9 SST POMC
22 abducens nerve disease 29.8 PRL POMC
23 hypogonadism 29.8 PROP1 PRL IGF1
24 pituitary hormone deficiency, combined, 2 29.8 PROP1 PRL POMC IGF1 GH1
25 gangliocytoma 29.8 PRL POMC
26 insulinoma 29.8 SSTR5 SST MEN1
27 nelson syndrome 29.8 SSTR5 SST PRL POMC
28 cranial nerve palsy 29.8 PRL POMC
29 goiter 29.7 SST PRL IGF1 GNAS
30 hyperthyroidism 29.7 SST PRL POMC IGF1 GNAS GH1
31 acanthosis nigricans 29.7 PRL IGF1 GH1
32 pituitary carcinoma 29.7 SST PRL POMC MEN1 GNAS
33 ectopic cushing syndrome 29.6 SST PRL POMC
34 prolactin producing pituitary tumor 29.6 SSTR5 PRL POMC
35 ovarian disease 29.6 PRL POMC IGF1 GH1
36 intracranial hypertension, idiopathic 29.6 POMC IGF1
37 acth-secreting pituitary adenoma 29.5 SSTR5 SST PTTG1 PRL POMC MEN1
38 sexual disorder 29.5 PRL POMC IGF1
39 hypoglycemia 29.4 SST PRL POMC IGF1 GH1
40 multiple endocrine neoplasia, type iv 29.4 MEN1 AIP
41 carcinoid syndrome 29.4 SST MEN1 IGF1
42 mccune-albright syndrome 29.4 SST PRL MEN1 IGF1 GNAS GH1
43 neuroendocrine tumor 29.4 SST POMC MEN1 IGF1
44 hypothyroidism, congenital, nongoitrous, 4 29.4 PROP1 PRL POMC GH1
45 thyroid gland medullary carcinoma 29.4 SST POMC MEN1
46 adenoma 29.4 SSTR5 SST PRL POMC MEN1 IGF1
47 thyroid carcinoma, familial medullary 29.3 SST POMC MEN1
48 hypothyroidism 29.2 SST PROP1 PRL POMC IGF1 GNAS
49 multiple endocrine neoplasia 29.1 SST POMC MEN1 GNAS CNC2 AIP
50 thyroid gland disease 29.1 SST PRL POMC IGF1 GNAS

Graphical network of the top 20 diseases related to Pituitary Tumors:



Diseases related to Pituitary Tumors
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Symptoms & Phenotypes for Pituitary Tumors

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MGI Mouse Phenotypes related to Pituitary Tumors:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 AIP GNAS IGF1 MEN1 POMC PRL
2 growth/size/body region MP:0005378 10.02 AIP GNAS IGF1 MEN1 POMC PROP1
3 homeostasis/metabolism MP:0005376 10 AIP GNAS IGF1 MEN1 POMC PRL
4 adipose tissue MP:0005375 9.88 GNAS IGF1 POMC PTTG1 RB1 SST
5 liver/biliary system MP:0005370 9.63 AIP GNAS MEN1 POMC PRL RB1
6 neoplasm MP:0002006 9.5 AIP GNAS IGF1 MEN1 POMC PRL
7 nervous system MP:0003631 9.28 GNAS IGF1 MEN1 POMC PRL PROP1
Sources

Drugs & Therapeutics for Pituitary Tumors

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Drugs for Pituitary Tumors (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 151)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
3
Cefazolin Approved Phase 4 25953-19-9 33255 656510
4
Cefdinir Approved Phase 4 91832-40-5 6915944
5
Sulfamethoxazole Approved Phase 4 723-46-6 5329
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
8
Octreotide Approved, Investigational Phase 4 83150-76-9 6400441 383414
9
Morphine Approved, Investigational Phase 4 57-27-2 5288826
10
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
11
Ibuprofen Approved Phase 4 15687-27-1 3672
12
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
13
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
14
Cabergoline Approved Phase 4 81409-90-7 54746
15
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
16
Quinagolide Approved, Investigational Phase 4 87056-78-8, 97805-50-0 105105
17
Lactitol Approved, Investigational Phase 4 585-86-4 157355
18
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
19
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
21
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
22
lanreotide Approved Phase 4 108736-35-2
23 cefuroxime axetil Phase 4
24 Cephalosporins Phase 4
25 Folic Acid Antagonists Phase 4
26 Cytochrome P-450 Enzyme Inhibitors Phase 4
27 Clindamycin phosphate Phase 4
28 Clindamycin palmitate Phase 4
29 Antiparasitic Agents Phase 4
30 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
31 Antiprotozoal Agents Phase 4
32 Anti-Infective Agents Phase 4
33 Antimalarials Phase 4
34 Gastrointestinal Agents Phase 4
35 Antineoplastic Agents, Hormonal Phase 4
36 Dopamine Agents Phase 4
37 Dopamine agonists Phase 4
38 Cardiotonic Agents Phase 4
39 Protective Agents Phase 4
40 Sympathomimetics Phase 4
41 Neurotransmitter Agents Phase 4
42 Anesthetics Phase 4
43 Adrenergic alpha-Agonists Phase 4
44 Analgesics, Non-Narcotic Phase 4
45 Hypnotics and Sedatives Phase 4
46 Analgesics Phase 4
47 Adrenergic Agents Phase 4
48 Adrenergic Agonists Phase 4
49 Anesthetics, Local Phase 4
50 Angiopeptin Phase 4

Interventional clinical trials:

(show top 50) (show all 122)
# Name Status NCT ID Phase Drugs
1 Effect of Dexmedetomidine as Anesthetic Coadjuvant on Plasmatic Cortisol Response in Transsphenoidal Surgery for Pituitary Tumors Unknown status NCT02549768 Phase 4 Dexmedetomidine;Sodium Chloride 0.9%
2 Comparative Low and High Dose of Dexmedethomidine Can Stabilize Hemodynamics and Blood Loss in Pituitary Tumor Removal by Transphenoid Approach Unknown status NCT03132259 Phase 4 high dose dexmedethomidine;low dose dexmedethomidine
3 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
4 A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study Evaluating the Impact of Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions Unknown status NCT03014687 Phase 4 Placebo;Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
5 Randomized, Double-Blind, Placebo-Controlled Trial Comparing Opioid-Sparing and Opioid-Containing Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors Completed NCT02351700 Phase 4 IV Caldolor (IV Ibuprofen);IV Ibuprofen placebo
6 Does Surgical Debulking Of Pituitary Adenomas Improve Responsiveness To Octreotide LAR In The Treatment Of Acromegaly: An Investigator-Initiated Study Completed NCT01371643 Phase 4 Octreotide LAR
7 PRolaCT - Three Multicenter Prolactinoma Randomized Clinical Trials Recruiting NCT04107480 Phase 4 Dopamine Agonists
8 An Open Label, Multi-center Pasireotide Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Pasireotide Study and Are Judged by the Investigator to Benefit From Continued Pasireotide Treatment Active, not recruiting NCT01794793 Phase 4 Pasireotide;Cabergoline;Pasireotide
9 The Effects of Infraorbital Nerve Block With Dexmedetomidine Added to Bupivacaine on Fentanyl Requirement During Endoscopic Transsphenoidal Approach to Remove Pituitary Tumor: Prospective Randomized Double Blinded Control Study Not yet recruiting NCT04785222 Phase 4 dexmedetomidine 5 mcg mixed with 0.5% plain bupivacaine
10 A Pilot Study of Pre- and Post-operative Somatuline Depot Therapy in Acromegalic Patients Treated by Endonasal Endoscopic Surgery: Impact on Early Remission Rates and Perioperative Morbidity Terminated NCT01861717 Phase 4 lanreotide
11 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Unknown status NCT02419664 Phase 3
12 A Phase III, Multicenter, Randomized, Parallel-group Study to Assess the Efficacy and Safety of Double-blind Pasireotide LAR 40 mg and Pasireotide LAR 60 mg Versus Open-label Octreotide LAR or Lanreotide ATG in Patients With Inadequately Controlled Acromegaly Completed NCT01137682 Phase 3 Pasireotide;octreotide LAR 30mg;lanreotide ATG 120mg
13 Study of Cabergoline in Treatment of Corticotroph Pituitary Tumor Completed NCT00889525 Phase 3 Cabergoline
14 Somatostatin and Dopamine Receptors Expression in Non-functioning Pituitary Adenomas and Resistant Prolactinomas: Correlation With in Vitro and in Vivo Responsiveness to Somatostatin Analogs and Dopamine Agonist Completed NCT01620138 Phase 2, Phase 3 Pasireotide;cabergoline
15 Dopamine Agonist Cabergoline in Residual Clinically Nonfunctioning Pituitary Adenoma After Transphenoidal Surgery: A Single Center, Open Label and Randomized Clinical Trial Completed NCT03271918 Phase 3 Cabergoline
16 Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas (NFPAs) - a Randomized Controlled Trial Recruiting NCT02288962 Phase 3 cabergoline
17 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma From an Endocrinological Point of View (MERGE Study): a Randomized, Phase 3 Trial Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
18 Radiotherapy Plus Concomitant Temozolomide for Refractory Pituitary Adenomas，A Randomized，Double-blind, Placebo-controlled Phase II Trial Not yet recruiting NCT04244708 Phase 2, Phase 3 Radiotherapy plus temozolomide
19 Pilot Study of Pasireotide LAR Treatment of Silent Corticotrophin Pituitary Tumors and Effects on Plasma Levels of POMC Unknown status NCT02749227 Phase 2 Pasireotide LAR
20 A Clinical Study to Evaluate the Safety and Efficacy of FolateScan (Technetium Tc 99m EC20) in Subjects With Pituitary Tumors Completed NCT01689727 Phase 2 Technetium Tc 99m EC20
21 Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy Completed NCT00939523 Phase 2 Lapatinib
22 Sandostatin LAR vs. Surgery in Acromegalics With Macroadenoma Completed NCT00001860 Phase 2 Sandostatin LAR Depot versus transsphenoidal surgery
23 An Open-Label, Single Arm, Phase II Study to Evaluate the Efficacy and Safety of Pasireotide LAR on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma Completed NCT01283542 Phase 2 Pasireotide LAR
24 Phase II Trial of Nivolumab Plus Ipilimumab in Patients With Aggressive Pituitary Tumors Recruiting NCT04042753 Phase 2 Ipilimumab;Nivolumab;Nivolumab
25 Capecitabine and Temozolomide for Treatment of Recurrent Pituitary Adenomas Recruiting NCT03930771 Phase 2 Capecitabine;Temozolomide
26 The Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease Recruiting NCT04339751 Phase 2 Vorinostat
27 A One Year, Randomized, Double-Blind, Placebo-Controlled Study of TBR-760 in Adult Patients With Non-Functioning Pituitary Adenomas Not yet recruiting NCT04335357 Phase 2 TBR-760;Placebo
28 A Phase II Trial to Assess the Efficacy and Safety of Pasireotide s.c. Alone or in Combination With Cabergoline in Patients With Cushing's Disease Terminated NCT01915303 Phase 2 Pasireotide with or without cabergoline
29 Effect of Pasireotide LAR on Gonadotroph Adenomas: A Pilot Study Terminated NCT00929669 Phase 2 pasireotide LAR
30 Rosiglitazone (Peroxisome Proliferating Activating Receptor-gamma {PPAR-y} Ligand) Treatment of Pituitary Tumors Terminated NCT00616642 Phase 2 rosiglitazone maleate
31 An Open Label, Multicenter, Single Arm Study of Pasireotide LAR in Patients With Rare Tumors of Neuroendocrine Origin Terminated NCT00958841 Phase 2 pasireotide LAR
32 An Open Label, Multicenter, Phase II Study Evaluating the Safety and Efficacy of Temozolomide Treatment in Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
33 Phase II Study of Antineoplastons A10 and AS2-1 in Patients With Metastatic or Incurable Neuroendocrine Tumors Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
34 Exploratory Phase 2 Study of Farletuzumab in Resectable Non-functioning Pituitary Adenoma Withdrawn NCT01203618 Phase 2 Farletuzumab
35 Detection of Functioning Pituitary Microadenoma With Inconclusive MRI Findings: PET/MRI Versus PET/CT Unknown status NCT03404414 Phase 1 18F-FDG
36 Detection of Pituitary Neuroendocrine Tumor (PitNET) Tissue During Endoscopic Transsphenoidal Surgery Using Bevacizumab-800CW Not yet recruiting NCT04212793 Phase 1 Bevacizumab-IRDye800CW
37 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
38 A Phase 1, Single Dose, Open-Label Study to Investigate the Safety and Efficacy of OTL38 Injection for Intraoperative Imaging of Folate Receptor-alpha Positive Pituitary Adenoma Terminated NCT02629549 Phase 1 OTL38
39 The Observational Study of the Structures and Functions of Multiple Organs in Patients With Growth Hormone-secreting Tumors Unknown status NCT01368133
40 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Unknown status NCT01556230
41 Extended Support Within a Person-centred Practice After Surgery: a Quasi- Experimental Study for Persons With Pituitary Tumours Unknown status NCT03927183
42 Impact of Nasoseptal Flap Harvest Technique on Olfaction Following Endoscopic Transsphenoidal Pituitary Surgery: A Single-blinded Randomized Controlled Trial Unknown status NCT03773705
43 PITUItary Carcinomas or Aggressive Tumors REgistry: Monocentric Study Form a Cohort of Patient Operated on for Pituitary Tumors in University Hospital of Lyon (France) Unknown status NCT02854228
44 Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery Unknown status NCT03719781
45 Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary Adenoma Unknown status NCT00598949
46 A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Unknown status NCT03309319 Rosiglitazone
47 Characterization of Receptors Present in Non-functioning Pituitary Macroadenomas by Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR) Unknown status NCT00852501
48 The Predictive Factors of Vision Recovery in Patients With Pituitary Tumor Unknown status NCT01377701
49 Genome-wide Association Study of Pituitary Tumors Unknown status NCT01442220
50 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332

Search NIH Clinical Center for Pituitary Tumors

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Octreotide
Octreotide Acetate
Sources

Genetic Tests for Pituitary Tumors

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Anatomical Context for Pituitary Tumors

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MalaCards organs/tissues related to Pituitary Tumors:

40
Pituitary, Hypothalamus, Adrenal Gland, Prostate, Testes, Endothelial, Thyroid
Sources

Publications for Pituitary Tumors

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Articles related to Pituitary Tumors:

(show top 50) (show all 6878)
# Title Authors PMID Year
1
The use of an O-arm in endonasal endoscopic operations of the skull base. 42
33485359 2021
2
Neurophthalmic manifestations of giant sellar tumors in adults: Relationship between endocrine status and visual acuity profile pre and postsurgical treatment: A prospective cohort study. 42
33221772 2020
3
Risk factors related to intracranial infections after transsphenoidal pituitary adenomectomy under endoscope. 42
33264535 2020
4
A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs. 61 54
20233783 2010
5
Pituitary tumor transforming gene binding factor: a new gene in breast cancer. 61 54
20406982 2010
6
Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes. 54 61
20106827 2010
7
The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells. 54 61
20068168 2010
8
Evolution of an aggressive prolactinoma into a growth hormone secreting pituitary tumor coincident with GNAS gene mutation. 61 54
19890024 2010
9
E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. 61 54
19837943 2009
10
Effect of PTTG on endogenous gene expression in HEK 293 cells. 61 54
19958546 2009
11
Acromegaly pathogenesis and treatment. 61 54
19884662 2009
12
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly. 61 54
19637311 2009
13
Somatostatin analog and pegvisomant combination therapy for acromegaly. 54 61
19763127 2009
14
Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis. 61 54
19549593 2009
15
Lanreotide promotes apoptosis and is not radioprotective in GH3 cells. 54 61
19528243 2009
16
Familial pituitary tumor syndromes. 54 61
19564887 2009
17
Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells. 54 61
19359387 2009
18
Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorogenic hyperprolactinemia. 54 61
19687170 2009
19
Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors. 61 54
19401364 2009
20
Pituitary enlargement in patients with PROP1 gene inactivating mutation represents cystic hyperplasia of the intermediate pituitary lobe. Histopathology and over 10 years follow-up of two patients. 61 54
19774847 2009
21
Novel oncogenic actions of TRbeta mutants in tumorigenesis. 61 54
19391168 2009
22
Serum ghrelin levels in growth hormone-sufficient and growth hormone-deficient patients during growth hormone-releasing hormone plus arginine test. 54 61
19636202 2009
23
PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma. 54 61
19351864 2009
24
Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment. 61 54
19353839 2009
25
RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors. 61 54
19020999 2009
26
Intrapituitary expression and regulation of the gp130 cytokine interleukin-6 and its implication in pituitary physiology and pathophysiology. 54 61
19236332 2009
27
Activin, TGF-beta and menin in pituitary tumorigenesis. 61 54
20175454 2009
28
The molecular biology of pituitary tumors: a personal perspective. 61 54
19058014 2009
29
Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas. 54 61
19318729 2009
30
Mutations of the gene for the aryl hydrocarbon receptor-interacting protein in pituitary adenomas. 54 61
19188737 2009
31
Genes differentially expressed in prolactinomas responsive and resistant to dopamine agonists. 54 61
18791324 2009
32
The relationship between prolactin (PRL), leptin, nitric oxide (NO), and cytokines in patients with hyperprolactinemia. 54 61
18752070 2009
33
The effects of hyperprolactinemia on bone and fat. 61 54
18338266 2009
34
Improvement of congestive heart failure after octreotide and transsphenoidal surgery in a patient with acromegaly. 54 61
19420816 2009
35
Aryl hydrocarbon receptor-interacting protein and pituitary adenomas: a population-based study on subjects exposed to dioxin after the Seveso, Italy, accident. 61 54
18787049 2008
36
Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway. 61 54
18715881 2008
37
Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. 61 54
19169048 2008
38
p21(Cip1) restrains pituitary tumor growth. 61 54
18981426 2008
39
Follow-up of pituitary tumor volume in patients with acromegaly treated with pegvisomant in clinical trials. 54 61
18708436 2008
40
Hypophysectomy for prostate cancer: a revival of old knowledge? 61 54
18826367 2008
41
Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. 54 61
18653781 2008
42
Increased incidence of autoimmune thyroiditis in patients with antipsychotic-induced hyperprolactinemia. 61 54
18539008 2008
43
Metabolic implications of growth hormone therapy. 61 54
19020393 2008
44
Estrogen receptors in human pituitary tumors. 54 61
18398784 2008
45
Treatment of pituitary gigantism with the growth hormone receptor antagonist pegvisomant. 54 61
18492755 2008
46
Effect of hyperprolactinemia during development in children and adolescents. 61 54
18816151 2008
47
In vitro testing of new somatostatin analogs on pituitary tumor cells. 54 61
18243520 2008
48
Levonorgestrel antagonism on estrogen-induced pituitary tumors is mediated by progesterone receptors. 54 61
18548383 2008
49
Low levels of raf kinase inhibitory protein in growth hormone-secreting pituitary adenomas correlate with poor response to octreotide treatment. 54 61
18230656 2008
50
Management of acromegaly: is there a role for primary medical therapy? 54 61
18163213 2008
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Variations for Pituitary Tumors

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Expression for Pituitary Tumors

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Search GEO for disease gene expression data for Pituitary Tumors.
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Pathways for Pituitary Tumors

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Pathways related to Pituitary Tumors according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 36
Show member pathways
 12.49 RB1 PRL IGF1 GNAS GH1
2
Aldosterone synthesis and secretion 36
Show member pathways
 12.32 RB1 POMC MEN1 GNAS AIP
3
Peptide hormone metabolism 65
Show member pathways
 11.87 POMC IGF1 GH1
4
Relaxin signaling pathway 36
Show member pathways
 11.7 SSTR5 SST POMC IGF1 GNAS GH1
5
Adipogenesis 1
11.62 RB1 IGF1 GH1
6
cAMP signaling pathway 36
11.59 SSTR5 SST POMC GNAS
7
AHR Pathway 63
10.8 RB1 AIP
8
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.67 PRL POMC
Sources

GO Terms for Pituitary Tumors

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Cellular components related to Pituitary Tumors according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRL GH1

Biological processes related to Pituitary Tumors according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.67 SSTR5 SST RB1 MEN1
2 regulation of multicellular organism growth GO:0040014 9.4 PRL IGF1
3 tissue homeostasis GO:0001894 9.32 RB1 GNAS
4 myoblast differentiation GO:0045445 9.26 RB1 IGF1
5 positive regulation of transcription regulatory region DNA binding GO:2000679 9.16 RB1 IGF1
6 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 PRL GH1
7 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGF1 GH1

Molecular functions related to Pituitary Tumors according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 9.16 IGF1 GNAS
2 hormone activity GO:0005179 9.02 SST PRL POMC IGF1 GH1
3 prolactin receptor binding GO:0005148 8.96 PRL GH1
Sources

Sources for Pituitary Tumors

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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