MCID: PTY004
MIFTS: 25

Pityriasis Lichenoides

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Pityriasis Lichenoides

MalaCards integrated aliases for Pityriasis Lichenoides:

Name: Pityriasis Lichenoides 20 70

Classifications:



External Ids:

UMLS 70 C0162853

Summaries for Pityriasis Lichenoides

GARD : 20 Pityriasis lichenoides (PL) is a skin condition characterized by small, raised pink spots that tend to come together in groups. It is not contagious. There are two main types of PL: an acute form called pityriasis lichenoides et varioliformis acuta (PLEVA), and a milder, longer-lasting form called pityriasis lichenoides chronica (PLC). There is also a rare, severe variant of PLEVA called febrile ulceronecrotic PLEVA, associated with high fever and complications that may affect other body systems. In both types of PL, spots usually occur on the trunk, buttox, arms and legs. PLEVA begins abruptly and may cause itching or burning. PLC may develop over days, is less irritating, and lasts longer than PLEVA. Spots associated with PLC typically fade within 3 to 4 weeks, but new spots may then appear. There is no clear consensus regarding how long either form of PL lasts, but most cases resolve on their own within one to several months. Some cases may wax and wane, or relapse over a period of years. The cause of PL is not known. Theories on the cause have included the possibility of a low-grade or self-limited lymphoproliferative disorder ; a reaction to a bacterial or viral infection; and an inappropriate, inflammatory immune response to an unknown foreign agent. Treatment options may include antibiotics, phototherapy, PUVA, or medications that suppress the immune system response (immunosuppressants) in severe cases.

MalaCards based summary : Pityriasis Lichenoides is related to pityriasis lichenoides et varioliformis acuta and parapsoriasis. An important gene associated with Pityriasis Lichenoides is CD7 (CD7 Molecule), and among its related pathways/superpathways is Hematopoietic cell lineage. The drugs Azithromycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and t cells.

Related Diseases for Pityriasis Lichenoides

Diseases related to Pityriasis Lichenoides via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 pityriasis lichenoides et varioliformis acuta 32.9 TNFRSF8 CD7
2 parapsoriasis 31.0 TNFRSF8 CD7
3 mycosis fungoides 30.8 TNFRSF8 CD7
4 skin disease 30.4 TNFRSF8 MX1 CD7
5 lymphoma, hodgkin, classic 30.0 TNFRSF8 MS4A1
6 lymphoma, non-hodgkin, familial 29.8 TNFRSF8 MS4A1 CD7
7 pityriasis lichenoides chronica 11.8
8 febrile ulceronecrotic mucha-habermann disease 11.3
9 lymphomatoid papulosis 10.7
10 cutaneous t cell lymphoma 10.6
11 exanthem 10.5
12 chickenpox 10.5
13 lymphoproliferative syndrome 10.4
14 mumps 10.4
15 pustulosis of palm and sole 10.4
16 measles 10.4
17 vasculitis 10.4
18 rubella 10.4
19 psoriasis 10.4
20 toxoplasmosis 10.4
21 lymphoma 10.3
22 pityriasis rosea 10.3
23 vasculitis, lymphocytic, nodular 10.3
24 erythema multiforme 10.3
25 secondary syphilis 10.3
26 syphilis 10.3
27 lichen planus 10.3
28 spondyloarthropathy 1 10.2
29 immune deficiency disease 10.2
30 human herpesvirus 8 10.2
31 dermatomyositis 10.2
32 inflammatory spondylopathy 10.2
33 dermatitis 10.2
34 spondylitis 10.2
35 lichen nitidus 10.2
36 guttate psoriasis 10.2
37 erythema multiforme major 10.2
38 pfeiffer syndrome 10.0
39 keratitis, hereditary 10.0
40 keratitis-ichthyosis-deafness syndrome, autosomal dominant 10.0
41 lichen sclerosus et atrophicus 10.0
42 mastocytosis, cutaneous 10.0
43 dowling-degos disease 1 10.0
44 rheumatoid arthritis 10.0
45 thrombocytopenic purpura, autoimmune 10.0
46 myeloma, multiple 10.0
47 branchiootic syndrome 1 10.0
48 dermatitis, atopic 10.0
49 psoriatic arthritis 10.0
50 severe cutaneous adverse reaction 10.0

Graphical network of the top 20 diseases related to Pityriasis Lichenoides:



Diseases related to Pityriasis Lichenoides

Symptoms & Phenotypes for Pityriasis Lichenoides

Drugs & Therapeutics for Pityriasis Lichenoides

Drugs for Pityriasis Lichenoides (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved 83905-01-5 447043 55185
2 Anti-Bacterial Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pityriasis Lichenoides: Anatomo-clinical Aspects and Follow-up Monocentric Retrospective Study Unknown status NCT03920696
2 Role of Streptococcal Infection in the Etiopathogenesis of Pityriasis Lichenoides Chronica and the Therapeutic Efficacy of Azithromycin; a Randomized Controlled Trial Unknown status NCT03831269 Azithromycin

Search NIH Clinical Center for Pityriasis Lichenoides

Genetic Tests for Pityriasis Lichenoides

Anatomical Context for Pityriasis Lichenoides

MalaCards organs/tissues related to Pityriasis Lichenoides:

40
Skin, Tongue, T Cells

Publications for Pityriasis Lichenoides

Articles related to Pityriasis Lichenoides:

(show top 50) (show all 481)
# Title Authors PMID Year
1
Phototherapy for Pityriasis Lichenoides in the Pediatric Population: A Review of the Published Literature. 20 61
27502793 2016
2
Pityriasis lichenoides: pathophysiology, classification, and treatment. 20 61
17298104 2007
3
Mycosis Fungoides Preceding Pityriasis Lichenoides et Varioliformis Acuta by Twelve Years in a Pediatric Patient. 61
33795555 2021
4
Skin and Mucous Membrane Eruptions Associated with Chlamydophila Pneumoniae Respiratory Infections: Literature Review. 61
32222707 2021
5
A Diagnostically Challenging Case of Febrile Ulceronecrotic Mucha-Habermann Disease in an Adult Female Successfully Treated with Methotrexate and Cyclosporine. 61
33613228 2021
6
Dermoscopic characterization of guttate psoriasis, pityriasis rosea, and pityriasis lichenoides chronica in dark skin phototypes: An observational study. 61
33277950 2021
7
Systematic review of the efficacies and adverse effects of treatments for pityriasis lichenoides. 61
32112390 2020
8
Pityriasis lichenoides et varioliformis acuta associated with anti-Ku-positive refractory interstitial lung disease and dermatomyositis. 61
33464622 2020
9
Lymphocytic vasculitis in pityriasis lichenoides et varioliformis acuta. 61
32309878 2020
10
Pityriasis lichenoides getriggert durch eine Masern-Mumps-Röteln-Impfung. 61
32713141 2020
11
Pityriasis lichenoides triggered by measles-mumps-rubella vaccine injection. 61
32656953 2020
12
Pityriasis lichenoides acuta (PLEVA) pemphigoides: A rare bullous variant of PLEVA. 61
32350916 2020
13
Pityriasis lichenoides et varioliformis acuta following measles rubella vaccine. 61
32474500 2020
14
A case of pityriasis lichenoides et varioliformis acuta after topical application of diphenylcyclopropenone. 61
32540809 2020
15
Clinical, Dermatoscopic, and Histological Findings in a Diagnosis of Pityriasis Lichenoides. 61
32699720 2020
16
Dermoscopy of Pityriasis Lichenoides Chronica in an Indian Girl. 61
32695726 2020
17
Oral erythromycin in pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta. 61
32174014 2020
18
Pityriasis lichenoides chronica: Rapid response after a single cycle of azithromycin therapy. 61
32157758 2020
19
Pityriasis Lichenoides-like Mycosis Fungoides in Children: A Challenging Diagnosis. 61
32434301 2020
20
Pityriasis Lichenoides Chronica in a Patient With Ankylosing Spondylitis Treated With Etanercept. 61
32484616 2020
21
Pityriasis Lichenoides Chronica in a Patient With Ankylosing Spondylitis Treated With Etanercept. 61
32550684 2020
22
Adverse Events Leading to Discontinuation of Phototherapy: An Observational Study. 61
32179932 2020
23
Pityriasis lichenoides et varioliformis acuta following anti-tetanus and diphtheria adult vaccine. 61
32156502 2020
24
Histopathologic features distinguishing secondary syphilis from its mimickers. 61
31306731 2020
25
Poikilodermatous Mycosis Fungoides: Comparative Study of Clinical, Histopathological and Immunohistochemical Features. 61
31550709 2020
26
Pityriasis Lichenoides: A Large Histopathological Case Series With a Focus on Adnexotropism. 61
31880634 2020
27
PUVA-induced pityriasis lichenoides chronica-like papular lesions in patients with mycosis fungoides: a clinical, histopathological and immunohistochemical study. 61
31300833 2019
28
A case of febrile ulceronecrotic Mucha-Habermann disease with comorbidities. 61
30860167 2019
29
A systematic review of treatments for pityriasis lichenoides. 61
31318465 2019
30
Lymphomatoid Papulosis and Other Lymphoma-Like Diseases. 61
31466587 2019
31
Papular Mycosis Fungoides Is a Distinctive Variant of Early-stage Mycosis Fungoides: Extended Retrospective Study With Long-term Follow-up. 61
30969178 2019
32
Pityriasis lichenoides et varioliformis acuta as presenting feature of acute human immunodeficiency virus infection. 61
31451481 2019
33
Combined immune therapy grade IV dermatitis in metastatic melanoma. 61
30809956 2019
34
A case of pityriasis lichenoides et varioliformis acuta pemphigoides successfully treated with methotrexate and corticosteroids. 61
30659712 2019
35
An Atypical Presentation of PLEVA: Case Report and Review of the Literature 61
31334928 2019
36
A case of lymphomatoid papulosis, pityriasis lichenoides acuta, and mycosis fungoides coexistence. 61
30198062 2019
37
Pityriasis Lichenoid-like Mycosis Fungoides in a 9-year-old Boy: A Case Report. 61
31032790 2019
38
Frequency of occurrence of polymorphic light eruption in patients treated with photohardening and patients treated with phototherapy for other diseases. 61
30267642 2019
39
The Effectiveness of Narrow Band Uvb (Nb-Uvb) In the Treatment of Pityriasis Lichenoides Chronica (PLC) In Vietnam. 61
30745964 2019
40
Clinical Aspects and Treatment of Pityriasis Lichenoides Et Varioliformis Acuta: A Retrospective Vietnamese Study. 61
30745957 2019
41
Aciclovir for treatment of pityriasis lichenoides? 61
29923208 2019
42
Efficacy of phototherapy in pityriasis lichenoides chronica of dark skin: A retrospective study from a tertiary center in Mexico. 61
30284351 2018
43
Frequent relapses in a child with nephrotic syndrome due to PLEVA. 61
30099945 2018
44
[Varicella under the clinical picture of pityriasis lichenoides et varioliformis acuta (PLEVA)]. 61
30264315 2018
45
A case of pityriasis lichenoides: Rapid resolution with azithromycin monotherapy in 3 weeks. 61
30133949 2018
46
Pitiryasis Lichenoides et Varioliformis Aacuta Associated With Human Herpesvirus 7. 61
29221609 2018
47
Varicella zoster virus as a possible trigger for the development of pityriasis lichenoides et varioliformis acuta: retrospective analysis of our institutional cases. 61
29797478 2018
48
Pityriasis Lichenoides, Atypical Pityriasis Lichenoides, and Related Conditions: A Study of 66 Cases. 61
29851705 2018
49
[Polymorphic and itchy rash in a 21-year-old woman]. 61
29159666 2018
50
The utilization of phototherapy in the department of dermatology, Hospital Kuala Lumpur: A 5-year audit. 61
29962494 2018

Variations for Pityriasis Lichenoides

Expression for Pityriasis Lichenoides

Search GEO for disease gene expression data for Pityriasis Lichenoides.

Pathways for Pityriasis Lichenoides

Pathways related to Pityriasis Lichenoides according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 MS4A1 CD7

GO Terms for Pityriasis Lichenoides

Cellular components related to Pityriasis Lichenoides according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.02 TNFRSF8 NOS2 MX1 MS4A1 CD7

Biological processes related to Pityriasis Lichenoides according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to bacterium GO:0009617 8.62 NOS2 MS4A1

Sources for Pityriasis Lichenoides

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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