MCID: PTY002
MIFTS: 38

Pityriasis Versicolor

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Pityriasis Versicolor

MalaCards integrated aliases for Pityriasis Versicolor:

Name: Pityriasis Versicolor 12 54 15 17 32
Tinea Versicolor 44 62 70
Infection by Pityrosporum Furfur 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9060
ICD9CM 34 111.0
MeSH 44 D014010
NCIt 50 C112833
SNOMED-CT 67 56454009
ICD10 32 B36.0
UMLS 70 C0040262

Summaries for Pityriasis Versicolor

PubMed Health : 62 About tinea versicolor: Tinea versicolor, also referred to as pityriasis versicolor, is a skin condition characterized by small patches of lighter or darker skin. It is caused by a type of fungus that is found on almost everyone’s skin. It is generally not harmful and it isn't contagious. Topical treatments, such as special creams or shampoos, are usually effective.

MalaCards based summary : Pityriasis Versicolor, also known as tinea versicolor, is related to epidermodysplasia verruciformis 1 and dermatophytosis. An important gene associated with Pityriasis Versicolor is TMC8 (Transmembrane Channel Like 8), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Tuberculosis. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and myeloid, and related phenotype is immune system.

Disease Ontology : 12 A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.

Wikipedia : 73 Tinea versicolor is a condition characterized by a skin eruption on the trunk and proximal extremities.... more...

Related Diseases for Pityriasis Versicolor

Diseases related to Pityriasis Versicolor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 epidermodysplasia verruciformis 1 31.5 TMC8 TMC6 RHOH IL7 CORO1A CIB1
2 dermatophytosis 30.6 SQLE CLEC7A CLEC6A CLEC4E
3 tinea cruris 30.5 SQLE CLEC6A
4 fungal infectious disease 30.2 CLEC7A CLEC6A CLEC4E
5 tinea pedis 30.2 SQLE CLEC7A CLEC6A
6 tinea corporis 29.8 SQLE CLEC7A CLEC6A CLEC4E
7 chromoblastomycosis 29.7 CLEC7A CLEC6A CLEC4E
8 chronic mucocutaneous candidiasis 29.7 CLEC7A CLEC6A CLEC4E
9 tinea capitis 29.5 SQLE CLEC7A CLEC6A CLEC4E
10 superficial mycosis 28.3 TMC8 TMC6 RNASE7 RHOH KRT31 CLEC7A
11 epidermodysplasia verruciformis 2 11.3
12 epidermodysplasia verruciformis 3 11.3
13 papillomatosis, confluent and reticulated 11.2
14 epidermodysplasia verruciformis 4 11.2
15 epidermodysplasia verruciformis 5 11.2
16 seborrheic dermatitis 10.6
17 skin disease 10.5
18 dermatomycosis 10.4
19 erythrasma 10.4
20 dermatitis 10.3
21 overgrowth syndrome 10.3
22 dowling-degos disease 1 10.3
23 dermatitis, atopic 10.3
24 folliculitis 10.3
25 angiokeratoma of fordyce 10.3 TMC8 TMC6
26 focal epithelial hyperplasia 10.2 TMC8 TMC6
27 plantar wart 10.2 TMC8 TMC6
28 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
29 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
30 papilloma 10.2
31 hansen's disease 10.2
32 anogenital venereal wart 10.2 TMC8 TMC6
33 pityriasis rubra pilaris 10.2
34 black piedra 10.2
35 white piedra 10.2
36 tinea nigra 10.2
37 leprosy 3 10.1
38 helicobacter pylori infection 10.1
39 tinea manuum 10.1
40 urticaria 10.1
41 telogen effluvium 10.1
42 pityriasis rotunda 10.1
43 whim syndrome 10.1 TMC8 TMC6
44 coronin-1a deficiency 10.1 TMC8 CORO1A
45 neonatal candidiasis 10.0 CLEC7A CLEC6A
46 trichosporonosis 10.0 CLEC7A CLEC6A
47 ostertagiasis 10.0 CLEC7A CLEC4E
48 fungal keratitis 10.0 CLEC7A CLEC4E
49 mycosis fungoides 10.0
50 kala-azar 1 10.0

Graphical network of the top 20 diseases related to Pityriasis Versicolor:



Diseases related to Pityriasis Versicolor

Symptoms & Phenotypes for Pityriasis Versicolor

MGI Mouse Phenotypes related to Pityriasis Versicolor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CIB1 CLEC4E CLEC6A CLEC7A CORO1A IL7

Drugs & Therapeutics for Pityriasis Versicolor

PubMed Health treatment related to Pityriasis Versicolor: 62

Tinea versicolor may improve a little in cool or dry weather, but it usually doesn’t go away on its own. There are a number of effective treatments . These mainly include creams, lotions and shampoos that contain antifungal substances. They are applied to all of the affected areas of skin on the head and body. The shampoo is used too, in order to get rid of the fungus on the scalp and hair. Otherwise it might spread back to the skin again. Depending on the exact product used, it needs to be left on for anywhere from a few minutes to several hours. The products are often put on in the evening and then rinsed off in the shower the next morning. But even when treatment works, it can take up to several weeks or months for the skin patches to disappear. Only in rare cases are tablets needed. Sometimes tinea versicolor comes back again after successful treatment . If this keeps happening, doctors sometimes recommend using a special shampoo (containing an active ingredient like selenium sulfide or ketoconazole ) on your skin and hair every two to four weeks. There are also oral medications (tablets) that can be taken every four weeks to prevent tinea versicolor from returning. This can greatly reduce the risk of it coming back.

Drugs for Pityriasis Versicolor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Ketoconazole Approved, Investigational Phase 4 65277-42-1 47576
4
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
5 Cytochrome P-450 CYP3A Inhibitors Phase 4
6 Hormones Phase 4
7 Hormone Antagonists Phase 4
8 Antifungal Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Selenium disulfide Phase 4
12
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
13
Voriconazole Approved Phase 2 137234-62-9 71616
14
Hydroxyitraconazole Phase 2 108222

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ketoconazole Foam 2% for the Treatment of Versicolor Completed NCT00830388 Phase 4 Ketoconazole 2% Foam
2 The Comparative Assessment of Mycological Efficacy, Safety, Recurrence, and Cost-effectiveness of Selenium Sulfide 1.8% Shampoo Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: a Double-blind Randomized Controlled Trial Completed NCT04007237 Phase 4 shampoo with different composition
3 Clinical Evaluation of a Formulated Nanoemulsion for Topical Application Completed NCT04110834 Phase 2 itraconazole gel once daily;itraconazole gel twice daily;placebo
4 Clinical Evaluation of a Formulated Nanoemulsion for Topical Application Completed NCT04110860 Phase 2 voriconazole gel once daily;voriconazole gel twice daily;placebo
5 Detection of IL1-7A and IL-17F Gene Polymorphism in Pityriasis Versicolor and Its Relation to Susceptibility to Infections. Recruiting NCT04769804

Search NIH Clinical Center for Pityriasis Versicolor

Inferred drug relations via UMLS 70 / NDF-RT 51 :


butenafine
Butenafine hydrochloride
ciclopirox
Ciclopirox olamine
Econazole
Econazole Nitrate
Ketoconazole
selenium sulfide
sodium thiosulfate
SODIUM THIOSULFATE CRYSTALS
sulconazole
Sulconazole nitrate
terbinafine
Terbinafine hydrochloride
Tolnaftate

Cochrane evidence based reviews: tinea versicolor

Genetic Tests for Pityriasis Versicolor

Anatomical Context for Pityriasis Versicolor

MalaCards organs/tissues related to Pityriasis Versicolor:

40
Skin, Ovary, Myeloid

Publications for Pityriasis Versicolor

Articles related to Pityriasis Versicolor:

(show top 50) (show all 1167)
# Title Authors PMID Year
1
Prevalence of different Malassezia species in pityriasis versicolor in central India. 54 61
20228545 2010
2
Identification of Malassezia species. 54 61
17642728 2004
3
A cross-sectional study on dermatoses among underwater workers: a new clinical sign of peculiar distribution pattern of lesions in sea urchin prick reaction revealed. 61
33377192 2021
4
Inflammasome-mediated Inflammation by Malassezia in human keratinocytes: A comparative analysis with different strains. 61
33206994 2021
5
Antagonistic Activity of Antimicrobial Metabolites Produced from Seaweed-Associated Bacillus amyloliquefaciens MTCC 10456 Against Malassezia spp. 61
33523421 2021
6
Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant. 61
32568838 2021
7
Next-Generation Sequencing Identifies a Homozygous Nonsense p.Tyr370* Mutation of the TMC6 Gene in a Mexican Pedigree with Epidermodysplasia Verruciformis. 61
33262542 2020
8
Pityriasis versicolor with uncommon localizations. 61
30428654 2020
9
A case of anti- pityriasis versicolor therapy that preserves healthy mycobiome. 61
32993612 2020
10
Erythrasma Revisited: Diagnosis, Differential Diagnoses, and Comprehensive Review of Treatment. 61
33145138 2020
11
Epidermodysplasia Verruciformis: A Rare Case Report. 61
32782865 2020
12
Epidemiological pattern of Malassezia, its phenotypic identification and antifungal susceptibility profile to azoles by broth microdilution method. 61
33154246 2020
13
Successful treatment of Pityriasis Versicolor by photodynamic therapy mediated by methylene blue. 61
32191815 2020
14
Epidemiological Pattern of Malassezia, its Phenotypic Identification and Antifungal Susceptibility Profile to Azoles by Broth Microdilution Method. 61
33589187 2020
15
Epidemiological characterization of pityriasis versicolor and distribution of Malassezia species among students in Hai Phong city, Vietnam. 61
33628976 2020
16
Epidemiological characterization of pityriasis versicolor and distribution of Malassezia species among students in Hai Phong city, Vietnam. 61
33628980 2020
17
Relationship between helicobacter pylori infection and pityriasis versicolor: can helicobacter pylori infection be a new etiologic factor for pityriasis versicolor? 61
32151117 2020
18
Susceptibilities of Malassezia strains from pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis to antifungal drugs. 61
32613106 2020
19
Comparative study between topically applied irradiated human amniotic membrane in combination with tea tree oil versus topical tioconazole in pityraisis versicolor treatment. 61
32162164 2020
20
Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study. 61
32182387 2020
21
Efficacy of Itraconazole in the Prevention of Recurrence of Tinea Versicolor: A Three Year Follow Up. 61
32506089 2020
22
Malassezia: a case of coexisting pityriasis versicolor and Malassezia folliculitis. 61
29926112 2020
23
Molecular epidemiology, in vitro susceptibility and exoenzyme screening of Malassezia clinical isolates. 61
32068525 2020
24
Molecular Identification and Quantification of Malassezia Species Isolated from Pityriasis Versicolor. 61
32477973 2020
25
308-nm excimer laser: a hopeful and optional therapy for pityriasis versicolor. 61
31935146 2020
26
Multidisciplinary Management of Chronic Atypical Facial Pain of Psychogenic Origin: A Unique Case Report. 61
32742102 2020
27
Dermatological conditions encountered in The Independent State of Samoa and an exploration of possible strategies to manage dermatological health-care needs in this resource-poor setting. 61
31319438 2020
28
Host Responses in an Ex Vivo Human Skin Model Challenged With Malassezia sympodialis. 61
33552997 2020
29
Malassezia-Associated Skin Diseases, the Use of Diagnostics and Treatment. 61
32266163 2020
30
Cutaneous disorders of adolescence among Nigerian secondary school students. 61
32774612 2020
31
Galleria mellonella as a Novelty in vivo Model of Host-Pathogen Interaction for Malassezia furfur CBS 1878 and Malassezia pachydermatis CBS 1879. 61
32432057 2020
32
Tinea InVersicolor: A Rare Distribution of a Common Eruption. 61
32104626 2020
33
Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts. 61
32850491 2020
34
Novel dermoscopic features of pityriasis versicolor-like macules in epidermodysplasia verruciformis. 61
31643110 2020
35
Epidermodysplasia verruciformis with plane warts over lower abdomen and genitals. 61
33062994 2020
36
Dermatologic Problems Commonly Seen by the Allergist/Immunologist. 61
31351991 2020
37
Prevalence of skin infections, infestations, and papular urticaria among adolescents in secondary schools in Calabar, Nigeria. 61
32116340 2019
38
Tinea versicolor of the neck as side effect of topical steroids for alopecia areata. 61
30668183 2019
39
Malassezia colonisation on a reconstructed human epidermis: Imaging studies. 61
31556177 2019
40
Topical ketoconazole: a systematic review of current dermatological applications and future developments. 61
30668185 2019
41
[Malassezia species causative of pityriasis versicolor in Paraguay]. 61
33660753 2019
42
Dermoscopy: An easy way to solve the diagnostic puzzle in pityriasis versicolor. 61
30117461 2019
43
Common Skin Disorders in Pediatric Skin of Color. 61
31655787 2019
44
Dermoscopy in the Evaluation of Pityriasis Versicolor: A Cross Sectional Study. 61
31807448 2019
45
Atypical Presentation of Sweat Dermatitis with Review of Literature. 61
31807452 2019
46
Epidemiology of dermatomycoses in southwest Poland, years 2011-2016. 61
31839778 2019
47
Epidemiology and dermatological comorbidity of seborrhoeic dermatitis: population-based study in 161 269 employees. 61
30802934 2019
48
Malassezia interaction with a reconstructed human epidermis: Keratinocyte immune response. 61
31278884 2019
49
Fungal Infection in a Post-renal Transplant Patient with Diaporthe. 61
33589046 2019
50
Fungal infection in a post-renal transplant patient with Diaporthe. 61
32003353 2019

Variations for Pityriasis Versicolor

Expression for Pityriasis Versicolor

Search GEO for disease gene expression data for Pityriasis Versicolor.

Pathways for Pityriasis Versicolor

Pathways related to Pityriasis Versicolor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.74 CLEC7A CLEC6A CLEC4E
2 11.39 CORO1A CLEC7A CLEC4E
3
Show member pathways
11.04 CLEC7A CLEC6A CLEC4E

GO Terms for Pityriasis Versicolor

Cellular components related to Pityriasis Versicolor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immunological synapse GO:0001772 8.62 RHOH CORO1A

Biological processes related to Pityriasis Versicolor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.5 CORO1A CLEC7A CIB1
2 defense response to fungus GO:0050832 9.26 RNASE7 CLEC6A
3 homeostasis of number of cells within a tissue GO:0048873 9.16 IL7 CORO1A
4 innate immune response GO:0045087 9.02 RNASE7 CORO1A CLEC7A CLEC6A CLEC4E
5 positive regulation of T cell differentiation GO:0045582 8.96 RHOH IL7

Molecular functions related to Pityriasis Versicolor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.33 CLEC7A CLEC6A CLEC4E
2 pattern recognition receptor activity GO:0038187 8.96 CLEC7A CLEC4E
3 mechanosensitive ion channel activity GO:0008381 8.62 TMC8 TMC6

Sources for Pityriasis Versicolor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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