MCID: PLC001
MIFTS: 47

Placenta Accreta

Categories: Fetal diseases

Aliases & Classifications for Placenta Accreta

MalaCards integrated aliases for Placenta Accreta:

Name: Placenta Accreta 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4744
ICD10 33 O43.21
MeSH 44 D010921
NCIt 50 C26856
SNOMED-CT 68 70129008
UMLS 73 C0032044

Summaries for Placenta Accreta

Disease Ontology : 12 A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

MalaCards based summary : Placenta Accreta is related to placental abruption and placental site trophoblastic tumor. An important gene associated with Placenta Accreta is ANGPT2 (Angiopoietin 2), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Placenta accreta occurs when all or part of the placenta attaches abnormally to the myometrium (the... more...

Related Diseases for Placenta Accreta

Diseases related to Placenta Accreta via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 placental abruption 30.1 FLT1 PGF
2 placental site trophoblastic tumor 29.8 CGB3 EGFR
3 placenta praevia 11.7
4 asherman's syndrome 10.4
5 hydatidiform mole, recurrent, 1 10.2
6 chorioamnionitis 10.2
7 disseminated intravascular coagulation 10.2
8 gestational trophoblastic neoplasm 10.2
9 choriocarcinoma 10.2
10 uterine inversion 10.2
11 intermittent claudication 10.1 ANGPT2 SERPINE1
12 chronic myocardial ischemia 10.1 ANGPT1 TEK
13 macrophage activation syndrome 10.1 ANGPT1 ANGPT2
14 mild pre-eclampsia 10.1 FLT1 PGF
15 capillary hemangioma 10.1 FLT1 TEK
16 epithelioid hemangioendothelioma 10.1 FLT1 PGF
17 intramuscular hemangioma 10.1 ANGPT1 TEK
18 cancer-associated retinopathy 10.1 FLT1 PGF
19 limb ischemia 10.1 ANGPT2 PGF TEK
20 corneal neovascularization 10.0 FLT1 TEK
21 atrial standstill 1 10.0
22 wolff-parkinson-white syndrome 10.0
23 sickle cell anemia 10.0
24 preterm premature rupture of the membranes 10.0
25 blood group, cromer system 10.0
26 peripartum cardiomyopathy 10.0
27 pulmonary hypertension 10.0
28 arteriovenous fistula 10.0
29 thrombosis 10.0
30 arteriovenous malformation 10.0
31 gestational diabetes 10.0
32 trophoblastic neoplasm 10.0
33 syphilis 10.0
34 pulmonary embolism 10.0
35 myotonic dystrophy 10.0
36 degos 'en cocarde' erythrokeratoderma 10.0
37 limb-body wall complex 10.0
38 myotonia atrophica 10.0
39 partial hydatidiform mole 10.0
40 adult respiratory distress syndrome 10.0 ANGPT2 SERPINB2 SERPINE1
41 exudative vitreoretinopathy 1 10.0 ANGPT2 FLT1 TEK
42 pyogenic granuloma 10.0 ANGPT1 ANGPT2 TEK
43 angiosarcoma 10.0 FLT1 TEK
44 epileptic encephalopathy, childhood-onset 10.0 ANGPT1 ANGPT2 SERPINE1
45 arteries, anomalies of 10.0 FLT1 PGF SERPINE1
46 hellp syndrome 10.0 FLT1 PGF SERPINE1
47 retinal vascular disease 10.0 FLT1 PGF
48 microvascular complications of diabetes 1 9.9 ANGPT1 ANGPT2 FLT1
49 placental insufficiency 9.9 ANGPT2 FLT1 PGF TEK
50 ectopic pregnancy 9.9 CGB3 PGF

Graphical network of the top 20 diseases related to Placenta Accreta:



Diseases related to Placenta Accreta

Symptoms & Phenotypes for Placenta Accreta

MGI Mouse Phenotypes related to Placenta Accreta:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 ANGPT1 ANGPT2 EGFR FLT1 PGF SERPINE1
2 homeostasis/metabolism MP:0005376 9.92 ANGPT1 ANGPT2 EGFR FLT1 PGF SERPINB2
3 immune system MP:0005387 9.86 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
4 embryo MP:0005380 9.85 ANGPT1 EGFR FLT1 MCL1 PGF TEK
5 mortality/aging MP:0010768 9.76 ANGPT1 ANGPT2 EGFR FLT1 MCL1 SERPINB2
6 muscle MP:0005369 9.35 ANGPT1 EGFR FLT1 SERPINB2 TEK
7 vision/eye MP:0005391 9.1 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK

Drugs & Therapeutics for Placenta Accreta

Drugs for Placenta Accreta (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3,Not Applicable 1197-18-8 5526
2 Antifibrinolytic Agents Phase 4,Phase 3,Not Applicable
3 Coagulants Phase 4,Phase 3,Not Applicable
4 Hemostatics Phase 4,Phase 3,Not Applicable
5
Letrozole Approved, Investigational Not Applicable 112809-51-5 3902
6
Progesterone Approved, Vet_approved Not Applicable 57-83-0 5994
7
Menotropins Approved Not Applicable 61489-71-2, 9002-68-0 5360545
8
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
9 Deslorelin Investigational, Vet_approved Not Applicable 57773-65-6
10 Steroid Synthesis Inhibitors Not Applicable
11 Estrogen Receptor Antagonists Not Applicable
12 Estrogens Not Applicable
13 Estrogen Antagonists Not Applicable
14 Hormones Not Applicable
15 Hormone Antagonists Not Applicable
16 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
17 Aromatase Inhibitors Not Applicable
18 acivicin
19 Fertility Agents Not Applicable
20 Vasopressins Not Applicable
21 Arginine Vasopressin Not Applicable

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Recruiting NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
2 Tranexamic Acid in Adherent Placenta (TAP) Withdrawn NCT02329756 Phase 3 Tranexamic Acid (TXA);Sodium Chloride 0.9%
3 Emergency Peripartum Hysterectomy: A Prospective Study in Iran Completed NCT01285258 Phase 2
4 Placenta Accreta&Its Complications in Placenta Previa Cases Unknown status NCT02606474
5 Antenatal Diagnosis of Placental Attachment Disorders Unknown status NCT02442518
6 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta Unknown status NCT02784886
7 Correlation Between PIF Maternal Serum Levels and Pregnancy Outcome Unknown status NCT01805102
8 Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS) Unknown status NCT01431352 Not Applicable Letrozole;Chinese herbal medicine granules or Chinese herbal medicine granules placebo
9 Placenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population Completed NCT02302573 Not Applicable contast-enhanced ultrasound with sonovue
10 Surgical Management of Placenta Accreta Completed NCT03668795
11 Clinical Situations at High Risk of Placenta Accreta / Percreta Completed NCT02010229
12 Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta Completed NCT03707132
13 TUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques Completed NCT02712099
14 Comparison Between Hysterectomy and Conservative Management in Treatment of Placenta Accreta Regarding Maternal Complication Completed NCT03327818
15 Transverse B-Lynch in Management of Placenta Accreta Completed NCT02943421
16 Balloon Catheters in Cases of Abnormal Placentation Completed NCT01373255 Not Applicable
17 Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta Completed NCT02966197 Not Applicable
18 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01289262 Not Applicable
19 The Placenta Previa and Fetal Weight Completed NCT03321435
20 Internal Iliac Artery Ligation and Abnormally Invasive Placenta Completed NCT02728232 Not Applicable
21 The Effectiveness of Double Incision Technique in Uterus Preserving Surgery for Placenta Percreta Completed NCT02702024 Not Applicable
22 Optimization of the Healing Process of the Uterine Scar Tissue After Re-cesarean Section Completed NCT02703519 Not Applicable
23 Early Prediction of Placenta Accreta by Ultrasound and Color Doppler Recruiting NCT03032770
24 Surgical Technique To Control Postpartum Hemorrhage Recruiting NCT03241849 Not Applicable
25 Comparison of N&H Sandwich Technique and Cesarean Hysterectomy in Management of Placenta Accreta Spectrum Recruiting NCT03701386 Not Applicable
26 Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum Recruiting NCT03570710 Not Applicable intravenous tranexamic acid;Topical tranexamic acid;Normal saline
27 Creatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Abnormal Adherent Placenta. Recruiting NCT03224780
28 Comparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar Recruiting NCT03437291
29 Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion . Recruiting NCT03638024
30 Role of Ultrasound in Diagnosis of Placenta Previa and MAP Recruiting NCT03416296
31 Uterine Cavity and Blood Flow After Conservative Management of Placenta Previa/Accreta Recruiting NCT02878187
32 Predictors of Scar Dehiscence in Patients With Previous Caesarean Section Recruiting NCT03140683
33 Transfusion of Whole Blood and Cesarean Delivery Recruiting NCT03523780
34 Fertility Post Placenta Accrete Recruiting NCT02821702 Not Applicable
35 ICSI Versus Conventional IVF in Non-male Factor Couples Recruiting NCT03428919 Not Applicable
36 ICSI Versus Conventional IVF in Couples With Non-severe Male Infertility Recruiting NCT03298633 Not Applicable
37 IVM Versus IVF in High Antral Follicle Count Patients Recruiting NCT03405701 Not Applicable
38 NIche Development With Closure of Cesarean Uterotomy by Modified or Conventional Two-layer Technique Active, not recruiting NCT02410395 Not Applicable
39 Sim (Scratch in Miscarriage) Study Active, not recruiting NCT02681627 Not Applicable
40 Use of ROTEM Intraoperatively in Women With Placenta Accreta Enrolling by invitation NCT02729974 Not Applicable
41 Diagnostic Accuracy of Doppler Ultrasound and Role of Uterine Artery Doppler Not yet recruiting NCT03530475 Not Applicable
42 Multidisciplinary Team in Management of Placenta Accreta Not yet recruiting NCT03372538
43 Magnetic Resonance Imaging (MRI ) Versus Ultrasound in Placenta Accreta Diagnosis Not yet recruiting NCT03813212
44 Ultrasound in Prediction of Operative Findings in Cesarean Section Among Placenta Accreta Cases Not yet recruiting NCT03286998
45 PDIUC Protocol for Placental Accreta Not yet recruiting NCT03273569 Not Applicable
46 Bilateral Internal Iliac Artery Ligation Before Cesarean Hysterectomy Not yet recruiting NCT03129035 Not Applicable
47 Intraoperative Ureteric Dissection vs Preoperative Ureteric Stenting in Women With Abnormally Invasive Placenta Not yet recruiting NCT03763916 Not Applicable
48 Delivery Timing in Morbidly Adherent Placentas: a Randomized, Controlled Trial Withdrawn NCT02635412 Not Applicable

Search NIH Clinical Center for Placenta Accreta

Cochrane evidence based reviews: placenta accreta

Genetic Tests for Placenta Accreta

Anatomical Context for Placenta Accreta

MalaCards organs/tissues related to Placenta Accreta:

41
Placenta, Uterus, Testes, Whole Blood, Endothelial, Cervix, Eye

Publications for Placenta Accreta

Articles related to Placenta Accreta:

(show top 50) (show all 645)
# Title Authors Year
1
The occurrence and severity of intra-abdominal adhesions in cases of pregnancies complicated by placenta accreta: A case control study. ( 29902712 )
2018
2
Intentional placental removal on suspicious placenta accreta spectrum: still prohibited? ( 29151230 )
2018
3
Placenta Accreta following Hysteroscopic Lysis of Adhesions Caused by Asherman's Syndrome: A Case Report and Literature Review. ( 29955406 )
2018
4
FIGO consensus guidelines on placenta accreta spectrum disorders: Conservative management. ( 29405320 )
2018
5
Subinvolution of the placental site associated with focal retained products of conception and placenta accreta mimicking uterine arteriovenous malformation on CT and MRI: a lesson to be learned. ( 29743751 )
2018
6
Impact of Targeted Scanning Protocols on Perinatal Outcomes in Pregnancies at Risk of Placenta Accreta Spectrum or Vasa Previa. ( 29353034 )
2018
7
Magnetic resonance imaging for diagnosis of placenta accreta spectrum disorders: still useful forA real-world practice. ( 29752929 )
2018
8
FIGO consensus guidelines on placenta accreta spectrum disorders: Prenatal diagnosis and screening. ( 29405319 )
2018
9
Bakri balloon for placenta accreta spectrum disorder: an alternative to caesarean hysterectomy? ( 29893151 )
2018
10
Placenta percreta is associated with more frequent severe maternal morbidity than placenta accreta. ( 29733839 )
2018
11
Prophylactic balloon occlusion of internal iliac arteries, common iliac arteries and infrarenal abdominal aorta in pregnancies complicated by placenta accreta: a retrospective cohort study. ( 29872910 )
2018
12
FIGO consensus guidelines on placenta accreta spectrum disorders: Epidemiology. ( 29405321 )
2018
13
FIGO consensus guidelines on placenta accreta spectrum disorders: Introduction. ( 29405322 )
2018
14
Placenta accreta spectrum disorders: A new standardized terminology better defining the condition. ( 29673011 )
2018
15
Matsubara-Takahashi cervix-holding technique for massive postpartum hemorrhage in patients with placenta previa with or without placenta accreta spectrum disorders. ( 29143329 )
2018
16
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
17
International survey of practices used in the diagnosis and management of placenta accreta spectrum disorders. ( 29149470 )
2018
18
The risk of placenta accreta following primary cesarean delivery. ( 29404741 )
2018
19
Reply to "Retained placenta accreta with marked vascularity, uterine artery pseudoaneurysm, and placental polyp: overlapping clinical entities?" ( 29143937 )
2018
20
Temporary intra-arterial balloon occlusion for placenta accreta spectrum disorders: always inflate? ( 29934656 )
2018
21
FIGO consensus guidelines on placenta accreta spectrum disorders: Nonconservative surgical management. ( 29405317 )
2018
22
Clinical application of stage operation in patients with placenta accreta after previous caesarean section. ( 29851793 )
2018
23
Prior cesarean section and placenta accreta spectrum disorders: some clarifications. ( 29916109 )
2018
24
Placenta accreta and balloon catheterization: the experience of a single center and an update of latest evidence of literature. ( 29777345 )
2018
25
Placenta Accreta Spectrum. ( 29669225 )
2018
26
Intra-abdominal Rupture of a Live Cervical Pregnancy with Placenta Accreta but Without Vaginal Bleeding. ( 29849260 )
2018
27
How about "The effect of intraoperative cell salvage on allogeneic blood transfusion for patients with placenta accreta"?: An observational study. ( 29851834 )
2018
28
Prior cesarean section and placenta accreta spectrum disorders: some clarifications. ( 29923020 )
2018
29
Imaging findings of concealed intra-amniotic hemorrhage in the setting of placenta previa and placenta accreta spectrum disorder. ( 29911274 )
2018
30
Case of heterotopic cervical pregnancy and total placenta accreta after artificial cycle frozen-thawed embryo transfer. ( 29371827 )
2018
31
Placenta accreta spectrum disorders: Prenatal diagnosis still lacks clinical correlation. ( 29924394 )
2018
32
Retained placenta accreta with marked vascularity, uterine artery pseudoaneurysm, and placental polyp: overlapping clinical entities? ( 29143936 )
2018
33
Placenta accreta spectrum disorder trends in the context of the universal two-child policy in China and the risk of hysterectomy. ( 29214633 )
2018
34
The new world of placenta accreta spectrum disorders. ( 29405318 )
2018
35
Detection of Asherman's syndrome after conservative management of placenta accreta: a case report. ( 30454053 )
2018
36
Placenta accreta complicated with peripartum cardiomyopathy. ( 29574429 )
2018
37
Assessment of Sensitivity and Specificity of Ultrasound and Magnetic Resonance Imaging in the Diagnosis of Placenta Accreta. ( 30428490 )
2018
38
Right external iliac artery thrombus following the use of resuscitative endovascular balloon occlusion of the aorta for placenta accreta. ( 30443322 )
2018
39
Clinical and Ultrasound Predictors of Placenta Accreta in Pregnant Women with Antepartum Diagnosis of Placenta Previa: A Multicenter Study. ( 30448828 )
2018
40
Obstetric Care Consensus No. 7 Summary: Placenta Accreta Spectrum. ( 30461691 )
2018
41
Obstetric Care Consensus No. 7: Placenta Accreta Spectrum. ( 30461695 )
2018
42
Expression of β-catenin in human trophoblast and its role in placenta accreta and placenta previa. ( 30465458 )
2018
43
Placenta Accreta Spectrum. ( 30471891 )
2018
44
Updates on the management of placenta accreta spectrum. ( 30486635 )
2018
45
The role of supracervical hysterectomy in reducing blood products requirement in the management of placenta accreta: A case control study. ( 30486702 )
2018
46
Placenta Accreta: A Spectrum of Predictable Risk, Diagnosis, and Morbidity. ( 30500963 )
2018
47
Prevalence and diagnostic accuracy of Doppler ultrasound of placenta accreta in Egypt. ( 28264611 )
2018
48
Placenta accreta spectrum: pathophysiology and evidence-based anatomy for prenatal ultrasound imaging. ( 28599899 )
2018
49
Second-trimester levels of fetoplacental hormones among women with placenta accreta spectrum disorders. ( 29044511 )
2018
50
Retrospective analysis of obstetric and anesthetic management of patients with placenta accreta spectrum disorders. ( 29080306 )
2018

Variations for Placenta Accreta

Expression for Placenta Accreta

Search GEO for disease gene expression data for Placenta Accreta.

Pathways for Placenta Accreta

Pathways related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
2
Show member pathways
13.12 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
3
Show member pathways
13.09 ANGPT1 ANGPT2 SERPINB2 SERPINE1 TEK
4
Show member pathways
13.02 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
5
Show member pathways
12.54 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
6 12.47 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
7
Show member pathways
12.38 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
8
Show member pathways
12.37 ANGPT1 ANGPT2 EGFR TEK
9
Show member pathways
12.2 EGFR FLT1 PGF
10
Show member pathways
12.18 EGFR FLT1 PGF TEK
11
Show member pathways
12.02 ANGPT1 ANGPT2 TEK
12
Show member pathways
11.99 EGFR FLT1 TEK
13 11.93 EGFR FLT1 TEK
14 11.93 ANGPT2 EGFR FLT1 TEK
15 11.85 EGFR MCL1 SERPINE1
16
Show member pathways
11.84 ANGPT1 ANGPT2 EGFR FLT1 PGF
17 11.65 ANGPT1 FLT1 TEK
18 11.64 ANGPT2 FLT1 TEK
19 11.35 EGFR MCL1
20 11.32 EGFR SERPINB2
21 11.26 EGFR FLT1
22 11.2 ANGPT1 TEK
23 11.15 FLT1 SERPINE1
24 11.1 ANGPT1 ANGPT2 EGFR FLT1 SERPINE1 TEK
25 11 ANGPT2 SERPINE1
26 10.96 ANGPT1 FLT1 TEK
27 10.82 ANGPT1 ANGPT2 MCL1 SERPINE1
28
Show member pathways
10.77 FLT1 PGF
29 10.75 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
30 10.66 SERPINB2 SERPINE1
31 10.1 ANGPT1 TEK

GO Terms for Placenta Accreta

Cellular components related to Placenta Accreta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ANGPT1 ANGPT2 CGB3 EGFR FLT1 PGF
2 membrane raft GO:0045121 9.5 ANGPT1 EGFR TEK
3 receptor complex GO:0043235 9.33 EGFR FLT1 TEK
4 extracellular region GO:0005576 9.28 ANGPT1 ANGPT2 CGB3 EGFR FLT1 PGF
5 basal plasma membrane GO:0009925 9.26 EGFR TEK

Biological processes related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.95 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
2 cell differentiation GO:0030154 9.87 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
3 negative regulation of apoptotic process GO:0043066 9.85 ANGPT1 EGFR FLT1 MCL1 SERPINB2 TEK
4 cell-cell signaling GO:0007267 9.8 CGB3 PGF TEK
5 MAPK cascade GO:0000165 9.8 ANGPT1 EGFR TEK
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 ANGPT1 EGFR FLT1 TEK
7 leukocyte migration GO:0050900 9.78 ANGPT1 ANGPT2 TEK
8 positive regulation of protein phosphorylation GO:0001934 9.77 EGFR PGF TEK
9 peptidyl-tyrosine phosphorylation GO:0018108 9.77 EGFR FLT1 TEK
10 response to hypoxia GO:0001666 9.76 ANGPT2 PGF TEK
11 protein autophosphorylation GO:0046777 9.75 EGFR FLT1 TEK
12 positive regulation of protein kinase B signaling GO:0051897 9.73 ANGPT1 EGFR TEK
13 positive regulation of MAPK cascade GO:0043410 9.71 EGFR FLT1 TEK
14 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 ANGPT1 EGFR FLT1 TEK
15 negative regulation of signal transduction GO:0009968 9.7 EGFR FLT1 TEK
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.69 ANGPT1 FLT1 TEK
17 positive regulation of angiogenesis GO:0045766 9.65 ANGPT2 FLT1 PGF SERPINE1 TEK
18 positive regulation of endothelial cell migration GO:0010595 9.64 ANGPT1 TEK
19 positive chemotaxis GO:0050918 9.64 ANGPT1 PGF
20 animal organ regeneration GO:0031100 9.63 ANGPT2 PGF
21 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 ANGPT1 SERPINE1 TEK
22 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.62 FLT1 TEK
23 blood vessel morphogenesis GO:0048514 9.61 ANGPT2 FLT1
24 sprouting angiogenesis GO:0002040 9.61 ANGPT1 PGF TEK
25 fibrinolysis GO:0042730 9.57 SERPINB2 SERPINE1
26 vascular endothelial growth factor signaling pathway GO:0038084 9.55 FLT1 PGF
27 glomerulus vasculature development GO:0072012 9.33 ANGPT1 ANGPT2 TEK
28 Tie signaling pathway GO:0048014 9.13 ANGPT1 ANGPT2 TEK
29 angiogenesis GO:0001525 9.1 ANGPT1 ANGPT2 FLT1 PGF SERPINE1 TEK

Molecular functions related to Placenta Accreta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.5 EGFR FLT1 TEK
2 signaling receptor binding GO:0005102 9.46 ANGPT1 ANGPT2 EGFR SERPINE1
3 protein tyrosine kinase activity GO:0004713 9.43 EGFR FLT1 TEK
4 growth factor binding GO:0019838 9.37 FLT1 TEK
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.13 ANGPT1 EGFR TEK
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 EGFR FLT1 TEK

Sources for Placenta Accreta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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