MCID: PLC001
MIFTS: 47

Placenta Accreta

Categories: Fetal diseases

Aliases & Classifications for Placenta Accreta

MalaCards integrated aliases for Placenta Accreta:

Name: Placenta Accreta 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4744
MeSH 45 D010921
NCIt 51 C26856
SNOMED-CT 69 70129008
ICD10 34 O43.21
UMLS 74 C0032044

Summaries for Placenta Accreta

Disease Ontology : 12 A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

MalaCards based summary : Placenta Accreta is related to placental abruption and placenta praevia. An important gene associated with Placenta Accreta is ANGPT2 (Angiopoietin 2), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and ovary, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Placenta accreta occurs when all or part of the placenta attaches abnormally to the myometrium (the... more...

Related Diseases for Placenta Accreta

Diseases related to Placenta Accreta via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 placental abruption 30.1 FLT1 PGF
2 placenta praevia 11.7
3 asherman's syndrome 10.5
4 atrial standstill 1 10.2
5 hydatidiform mole, recurrent, 1 10.2
6 chorioamnionitis 10.2
7 disseminated intravascular coagulation 10.2
8 gestational trophoblastic neoplasm 10.2
9 choriocarcinoma 10.2
10 uterine inversion 10.2
11 intermittent claudication 10.1 ANGPT2 SERPINE1
12 mild pre-eclampsia 10.1 FLT1 PGF
13 capillary hemangioma 10.1 FLT1 TEK
14 limb ischemia 10.1 ANGPT2 PGF TEK
15 epithelioid hemangioendothelioma 10.1 FLT1 PGF
16 macrophage activation syndrome 10.1 ANGPT1 ANGPT2
17 chronic myocardial ischemia 10.1 ANGPT1 TEK
18 cancer-associated retinopathy 10.1 FLT1 PGF
19 intramuscular hemangioma 10.1 ANGPT1 TEK
20 wolff-parkinson-white syndrome 10.0
21 sickle cell anemia 10.0
22 preterm premature rupture of the membranes 10.0
23 blood group, cromer system 10.0
24 peripartum cardiomyopathy 10.0
25 pulmonary hypertension 10.0
26 arteriovenous fistula 10.0
27 thrombosis 10.0
28 arteriovenous malformation 10.0
29 gestational diabetes 10.0
30 placental site trophoblastic tumor 10.0
31 trophoblastic neoplasm 10.0
32 syphilis 10.0
33 pulmonary embolism 10.0
34 myotonic dystrophy 10.0
35 degos 'en cocarde' erythrokeratoderma 10.0
36 limb-body wall complex 10.0
37 myotonia atrophica 10.0
38 partial hydatidiform mole 10.0
39 adult respiratory distress syndrome 10.0 ANGPT2 SERPINB2 SERPINE1
40 exudative vitreoretinopathy 1 10.0 ANGPT2 FLT1 TEK
41 pyogenic granuloma 9.9 ANGPT1 ANGPT2 TEK
42 arteries, anomalies of 9.9 FLT1 PGF SERPINE1
43 hellp syndrome 9.9 FLT1 PGF SERPINE1
44 epileptic encephalopathy, childhood-onset 9.9 ANGPT1 ANGPT2 SERPINE1
45 corneal neovascularization 9.9 FLT1 TEK
46 breast carcinoma in situ 9.8 EGFR FLT1
47 placental insufficiency 9.8 ANGPT2 FLT1 PGF TEK
48 microvascular complications of diabetes 1 9.8 ANGPT1 ANGPT2 FLT1
49 angiosarcoma 9.8 FLT1 TEK
50 geographic tongue 9.8 EGFR TNFRSF10B

Graphical network of the top 20 diseases related to Placenta Accreta:



Diseases related to Placenta Accreta

Symptoms & Phenotypes for Placenta Accreta

MGI Mouse Phenotypes related to Placenta Accreta:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 ANGPT1 ANGPT2 EGFR FLT1 PGF SERPINE1
2 homeostasis/metabolism MP:0005376 9.92 ANGPT1 ANGPT2 EGFR FLT1 PGF SERPINB2
3 immune system MP:0005387 9.86 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
4 embryo MP:0005380 9.85 ANGPT1 EGFR FLT1 MCL1 PGF TEK
5 mortality/aging MP:0010768 9.76 ANGPT1 ANGPT2 EGFR FLT1 MCL1 SERPINB2
6 muscle MP:0005369 9.35 ANGPT1 EGFR FLT1 SERPINB2 TEK
7 vision/eye MP:0005391 9.1 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK

Drugs & Therapeutics for Placenta Accreta

Drugs for Placenta Accreta (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3,Not Applicable 1197-18-8 5526
2 Antifibrinolytic Agents Phase 4,Phase 3,Not Applicable
3 Coagulants Phase 4,Phase 3,Not Applicable
4 Hemostatics Phase 4,Phase 3,Not Applicable
5
Letrozole Approved, Investigational Not Applicable 112809-51-5 3902
6
Progesterone Approved, Vet_approved Not Applicable 57-83-0 5994
7
Menotropins Approved Not Applicable 9002-68-0, 61489-71-2 5360545
8
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
9 Deslorelin Investigational, Vet_approved Not Applicable 57773-65-6
10 Steroid Synthesis Inhibitors Not Applicable
11 Estrogen Antagonists Not Applicable
12 Hormones Not Applicable
13 Estrogen Receptor Antagonists Not Applicable
14 Aromatase Inhibitors Not Applicable
15 Hormone Antagonists Not Applicable
16 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
17 Estrogens Not Applicable
18 acivicin
19 Triptorelin Pamoate Not Applicable
20 Chorionic Gonadotropin Not Applicable
21 Fertility Agents Not Applicable
22 Vasopressins Not Applicable
23 Arginine Vasopressin Not Applicable

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Completed NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
2 Internal Iliac Artery Ligation Before Cesarean Hysterectomy in Morbidly Adherent Placenta Completed NCT03824873 Phase 3
3 Tranexamic Acid in Adherent Placenta (TAP) Withdrawn NCT02329756 Phase 3 Tranexamic Acid (TXA);Sodium Chloride 0.9%
4 Emergency Peripartum Hysterectomy: A Prospective Study in Iran Completed NCT01285258 Phase 2
5 Use of ROTEM Intraoperatively in Women With Placenta Accreta Unknown status NCT02729974 Not Applicable
6 Placenta Accreta&Its Complications in Placenta Previa Cases Unknown status NCT02606474
7 Bilateral Internal Iliac Artery Ligation Before Cesarean Hysterectomy Unknown status NCT03129035 Not Applicable
8 Antenatal Diagnosis of Placental Attachment Disorders Unknown status NCT02442518
9 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta Unknown status NCT02784886
10 Correlation Between PIF Maternal Serum Levels and Pregnancy Outcome Unknown status NCT01805102
11 Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS) Unknown status NCT01431352 Not Applicable Letrozole;Chinese herbal medicine granules or Chinese herbal medicine granules placebo
12 Placenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population Completed NCT02302573 Not Applicable contast-enhanced ultrasound with sonovue
13 Surgical Management of Placenta Accreta Completed NCT03668795
14 Clinical Situations at High Risk of Placenta Accreta / Percreta Completed NCT02010229
15 Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta Completed NCT03707132
16 TUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques Completed NCT02712099
17 Comparison Between Hysterectomy and Conservative Management in Treatment of Placenta Accreta Regarding Maternal Complication Completed NCT03327818
18 Transverse B-Lynch in Management of Placenta Accreta Completed NCT02943421
19 Balloon Catheters in Cases of Abnormal Placentation Completed NCT01373255 Not Applicable
20 Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta Completed NCT02966197 Not Applicable
21 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01289262 Not Applicable
22 The Placenta Previa and Fetal Weight Completed NCT03321435
23 Internal Iliac Artery Ligation and Abnormally Invasive Placenta Completed NCT02728232 Not Applicable
24 The Effectiveness of Double Incision Technique in Uterus Preserving Surgery for Placenta Percreta Completed NCT02702024 Not Applicable
25 Sim (Scratch in Miscarriage) Study Completed NCT02681627 Not Applicable
26 Optimization of the Healing Process of the Uterine Scar Tissue After Re-cesarean Section Completed NCT02703519 Not Applicable
27 Early Prediction of Placenta Accreta by Ultrasound and Color Doppler Recruiting NCT03032770
28 Surgical Technique To Control Postpartum Hemorrhage Recruiting NCT03241849 Not Applicable
29 Comparison of N&H Sandwich Technique and Cesarean Hysterectomy in Management of Placenta Accreta Spectrum Recruiting NCT03701386 Not Applicable
30 Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum Recruiting NCT03570710 Not Applicable intravenous tranexamic acid;Topical tranexamic acid;Normal saline
31 Creatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Abnormal Adherent Placenta. Recruiting NCT03224780
32 Comparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar Recruiting NCT03437291
33 Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion . Recruiting NCT03638024
34 Role of Ultrasound in Diagnosis of Placenta Previa and MAP Recruiting NCT03416296
35 Uterine Cavity and Blood Flow After Conservative Management of Placenta Previa/Accreta Recruiting NCT02878187
36 Predictors of Scar Dehiscence in Patients With Previous Caesarean Section Recruiting NCT03140683
37 Transfusion of Whole Blood and Cesarean Delivery Recruiting NCT03523780
38 Fertility Post Placenta Accrete Recruiting NCT02821702 Not Applicable
39 ICSI Versus Conventional IVF in Non-male Factor Couples Recruiting NCT03428919 Not Applicable
40 ICSI Versus Conventional IVF in Couples With Non-severe Male Infertility Recruiting NCT03298633 Not Applicable
41 IVM Versus IVF in High Antral Follicle Count Patients Recruiting NCT03405701 Not Applicable
42 NIche Development With Closure of Cesarean Uterotomy by Modified or Conventional Two-layer Technique Active, not recruiting NCT02410395 Not Applicable
43 Diagnostic Accuracy of Doppler Ultrasound and Role of Uterine Artery Doppler Not yet recruiting NCT03530475 Not Applicable
44 Multidisciplinary Team in Management of Placenta Accreta Not yet recruiting NCT03372538
45 Magnetic Resonance Imaging (MRI ) Versus Ultrasound in Placenta Accreta Diagnosis Not yet recruiting NCT03813212
46 Ultrasound in Prediction of Operative Findings in Cesarean Section Among Placenta Accreta Cases Not yet recruiting NCT03286998
47 PDIUC Protocol for Placental Accreta Not yet recruiting NCT03273569 Not Applicable
48 Intraoperative Ureteric Dissection vs Preoperative Ureteric Stenting in Women With Abnormally Invasive Placenta Not yet recruiting NCT03763916 Not Applicable
49 Delivery Timing in Morbidly Adherent Placentas: a Randomized, Controlled Trial Withdrawn NCT02635412 Not Applicable

Search NIH Clinical Center for Placenta Accreta

Cochrane evidence based reviews: placenta accreta

Genetic Tests for Placenta Accreta

Anatomical Context for Placenta Accreta

MalaCards organs/tissues related to Placenta Accreta:

42
Placenta, Uterus, Ovary, Whole Blood, Endothelial, Cervix, Eye

Publications for Placenta Accreta

Articles related to Placenta Accreta:

(show top 50) (show all 668)
# Title Authors Year
1
Prenatal planning of placenta previa: diagnostic accuracy of a novel MRI-based prediction model for placenta accreta spectrum (PAS) and clinical outcome. ( 30600374 )
2019
2
First-trimester abortion complicated with placenta accreta: A systematic review. ( 30638461 )
2019
3
Clinical evaluation of prophylactic abdominal aortic balloon occlusion in patients with placenta accreta: a systematic review and meta-analysis. ( 30646863 )
2019
4
Research on the expression of MRNA-518b in the pathogenesis of placenta accreta. ( 30657542 )
2019
5
Systematic review on near miss cases of placenta accreta spectrum disorders: correlation with invasion topography, prenatal imaging, and surgical outcome. ( 30700221 )
2019
6
Prophylactic Occlusion Balloon Placement in the Abdominal Aorta Combined with Uterine or Ovarian Artery Embolization for the Prevention of Cesarean Hysterectomy Due to Placenta Accreta: A Retrospective Study. ( 30701289 )
2019
7
Prevalence and main outcomes of placenta accreta spectrum: a systematic review and metaanalysis. ( 30716286 )
2019
8
Two important techniques in cesarean hysterectomy for placenta accreta spectrum disorders. ( 30730247 )
2019
9
Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders. ( 30759440 )
2019
10
Impact of placenta previa with placenta accreta spectrum disorder on fetal growth. ( 30779235 )
2019
11
Downregulation of MicroRNA-125a in Placenta Accreta Spectrum Disorders Contributes Antiapoptosis of Implantation Site Intermediate Trophoblasts by Targeting MCL1. ( 30782086 )
2019
12
Proposal for ultrasound staging of placenta accreta spectrum disorders. ( 30834661 )
2019
13
Expression of Cripto-1 in the placenta and its role in placenta accreta and placenta previa. ( 30860275 )
2019
14
Comparison of placenta accreta spectrum disorders diagnosed in intrapartum and antepartum period- A three year experience in a tertiary referral unit of India. ( 30878896 )
2019
15
Internal Iliac Artery Balloon Tamponade in Placenta Accreta: Outcomes From the Largest Tertiary Accreta Referral Centre in British Columbia. ( 30885297 )
2019
16
High-intensity focused ultrasound combined procedures treatment of retained placenta accreta with marked vascularity after abortion or delivery. ( 30892148 )
2019
17
Hyperglycosylated hCG and Placenta Accreta Spectrum. ( 29490399 )
2019
18
Clinical Diagnosis of Placenta Accreta and Clinicopathological Outcomes. ( 30193384 )
2019
19
The occurrence and severity of intra-abdominal adhesions in cases of pregnancies complicated by placenta accreta: A case control study. ( 29902712 )
2018
20
Intentional placental removal on suspicious placenta accreta spectrum: still prohibited? ( 29151230 )
2018
21
Placenta Accreta following Hysteroscopic Lysis of Adhesions Caused by Asherman's Syndrome: A Case Report and Literature Review. ( 29955406 )
2018
22
FIGO consensus guidelines on placenta accreta spectrum disorders: Conservative management. ( 29405320 )
2018
23
Subinvolution of the placental site associated with focal retained products of conception and placenta accreta mimicking uterine arteriovenous malformation on CT and MRI: a lesson to be learned. ( 29743751 )
2018
24
Impact of Targeted Scanning Protocols on Perinatal Outcomes in Pregnancies at Risk of Placenta Accreta Spectrum or Vasa Previa. ( 29353034 )
2018
25
Magnetic resonance imaging for diagnosis of placenta accreta spectrum disorders: still useful forA real-world practice. ( 29752929 )
2018
26
FIGO consensus guidelines on placenta accreta spectrum disorders: Prenatal diagnosis and screening. ( 29405319 )
2018
27
Bakri balloon for placenta accreta spectrum disorder: an alternative to caesarean hysterectomy? ( 29893151 )
2018
28
Placenta percreta is associated with more frequent severe maternal morbidity than placenta accreta. ( 29733839 )
2018
29
Prophylactic balloon occlusion of internal iliac arteries, common iliac arteries and infrarenal abdominal aorta in pregnancies complicated by placenta accreta: a retrospective cohort study. ( 29872910 )
2018
30
FIGO consensus guidelines on placenta accreta spectrum disorders: Epidemiology. ( 29405321 )
2018
31
FIGO consensus guidelines on placenta accreta spectrum disorders: Introduction. ( 29405322 )
2018
32
Placenta accreta spectrum disorders: A new standardized terminology better defining the condition. ( 29673011 )
2018
33
Matsubara-Takahashi cervix-holding technique for massive postpartum hemorrhage in patients with placenta previa with or without placenta accreta spectrum disorders. ( 29143329 )
2018
34
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
35
International survey of practices used in the diagnosis and management of placenta accreta spectrum disorders. ( 29149470 )
2018
36
The risk of placenta accreta following primary cesarean delivery. ( 29404741 )
2018
37
Reply to "Retained placenta accreta with marked vascularity, uterine artery pseudoaneurysm, and placental polyp: overlapping clinical entities?" ( 29143937 )
2018
38
Temporary intra-arterial balloon occlusion for placenta accreta spectrum disorders: always inflate? ( 29934656 )
2018
39
FIGO consensus guidelines on placenta accreta spectrum disorders: Nonconservative surgical management. ( 29405317 )
2018
40
Clinical application of stage operation in patients with placenta accreta after previous caesarean section. ( 29851793 )
2018
41
Prior cesarean section and placenta accreta spectrum disorders: some clarifications. ( 29916109 )
2018
42
Placenta accreta and balloon catheterization: the experience of a single center and an update of latest evidence of literature. ( 29777345 )
2018
43
Placenta Accreta Spectrum. ( 29669225 )
2018
44
Intra-abdominal Rupture of a Live Cervical Pregnancy with Placenta Accreta but Without Vaginal Bleeding. ( 29849260 )
2018
45
How about "The effect of intraoperative cell salvage on allogeneic blood transfusion for patients with placenta accreta"?: An observational study. ( 29851834 )
2018
46
Prior cesarean section and placenta accreta spectrum disorders: some clarifications. ( 29923020 )
2018
47
Imaging findings of concealed intra-amniotic hemorrhage in the setting of placenta previa and placenta accreta spectrum disorder. ( 29911274 )
2018
48
Case of heterotopic cervical pregnancy and total placenta accreta after artificial cycle frozen-thawed embryo transfer. ( 29371827 )
2018
49
Placenta accreta spectrum disorders: Prenatal diagnosis still lacks clinical correlation. ( 29924394 )
2018
50
Retained placenta accreta with marked vascularity, uterine artery pseudoaneurysm, and placental polyp: overlapping clinical entities? ( 29143936 )
2018

Variations for Placenta Accreta

Expression for Placenta Accreta

Search GEO for disease gene expression data for Placenta Accreta.

Pathways for Placenta Accreta

Pathways related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
2
Show member pathways
13.43 ANGPT1 ANGPT2 EGFR FLT1 TEK TNFRSF10B
3
Show member pathways
13.32 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
4
Show member pathways
13.19 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
5
Show member pathways
13.1 ANGPT1 ANGPT2 SERPINB2 SERPINE1 TEK TNFRSF10B
6
Show member pathways
13.04 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
7
Show member pathways
12.53 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
8 12.51 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
9
Show member pathways
12.44 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
10
Show member pathways
12.41 ANGPT1 ANGPT2 EGFR TEK
11
Show member pathways
12.2 EGFR FLT1 PGF
12
Show member pathways
12.19 EGFR FLT1 PGF TEK
13
Show member pathways
12.08 ANGPT1 ANGPT2 TEK TNFRSF10B
14
Show member pathways
12 EGFR FLT1 TEK
15 11.98 ANGPT2 EGFR FLT1 TEK
16 11.94 EGFR FLT1 TEK
17 11.9 EGFR MCL1 SERPINE1 TNFRSF10B
18
Show member pathways
11.75 ANGPT1 ANGPT2 EGFR FLT1 PGF TNFRSF10B
19 11.7 ANGPT1 FLT1 TEK
20 11.68 ANGPT2 FLT1 TEK
21 11.36 EGFR MCL1
22 11.33 EGFR SERPINB2
23 11.27 EGFR FLT1
24 11.2 ANGPT1 TEK
25 11.15 FLT1 SERPINE1
26 11.1 ANGPT1 ANGPT2 EGFR FLT1 SERPINE1 TEK
27 11.01 ANGPT2 SERPINE1
28 11.01 ANGPT1 FLT1 TEK
29 10.82 ANGPT1 ANGPT2 MCL1 SERPINE1
30 10.78 ANGPT1 ANGPT2 EGFR FLT1 PGF TEK
31 10.7 SERPINB2 SERPINE1
32 10.1 ANGPT1 TEK

GO Terms for Placenta Accreta

Cellular components related to Placenta Accreta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.86 ANGPT1 ANGPT2 EGFR FLT1 SERPINB2 SERPINE1
2 membrane raft GO:0045121 9.54 ANGPT1 EGFR TEK
3 extracellular space GO:0005615 9.5 ANGPT1 ANGPT2 EGFR FLT1 PGF SERPINB2
4 receptor complex GO:0043235 9.33 EGFR FLT1 TEK
5 basal plasma membrane GO:0009925 9.32 EGFR TEK
6 extracellular region GO:0005576 9.23 ANGPT1 ANGPT2 EGFR FLT1 PGF SERPINB2

Biological processes related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.97 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 ANGPT1 EGFR FLT1 TEK
3 MAPK cascade GO:0000165 9.8 ANGPT1 EGFR TEK
4 cell differentiation GO:0030154 9.8 ANGPT1 ANGPT2 EGFR FLT1 MCL1 PGF
5 leukocyte migration GO:0050900 9.78 ANGPT1 ANGPT2 TEK TNFRSF10B
6 positive regulation of protein phosphorylation GO:0001934 9.77 EGFR PGF TEK
7 peptidyl-tyrosine phosphorylation GO:0018108 9.77 EGFR FLT1 TEK
8 negative regulation of apoptotic process GO:0043066 9.77 ANGPT1 EGFR MCL1 SERPINB2 TEK
9 response to hypoxia GO:0001666 9.76 ANGPT2 PGF TEK
10 protein autophosphorylation GO:0046777 9.75 EGFR FLT1 TEK
11 positive regulation of protein kinase B signaling GO:0051897 9.73 ANGPT1 EGFR TEK
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 ANGPT1 EGFR FLT1 TEK
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.7 ANGPT1 FLT1 TEK
14 positive regulation of angiogenesis GO:0045766 9.65 ANGPT2 FLT1 PGF SERPINE1 TEK
15 positive regulation of endothelial cell migration GO:0010595 9.64 ANGPT1 TEK
16 positive chemotaxis GO:0050918 9.63 ANGPT1 PGF
17 animal organ regeneration GO:0031100 9.63 ANGPT2 PGF
18 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 ANGPT1 SERPINE1 TEK
19 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.62 SERPINE1 TNFRSF10B
20 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.61 FLT1 TEK
21 blood vessel morphogenesis GO:0048514 9.61 ANGPT2 FLT1
22 sprouting angiogenesis GO:0002040 9.61 ANGPT1 PGF TEK
23 fibrinolysis GO:0042730 9.57 SERPINB2 SERPINE1
24 vascular endothelial growth factor signaling pathway GO:0038084 9.55 FLT1 PGF
25 glomerulus vasculature development GO:0072012 9.33 ANGPT1 ANGPT2 TEK
26 positive regulation of MAPK cascade GO:0043410 9.24 FLT1
27 Tie signaling pathway GO:0048014 9.13 ANGPT1 ANGPT2 TEK
28 angiogenesis GO:0001525 9.1 ANGPT1 ANGPT2 FLT1 PGF SERPINE1 TEK

Molecular functions related to Placenta Accreta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 ANGPT1 ANGPT2 EGFR SERPINE1
2 protein tyrosine kinase activity GO:0004713 9.43 EGFR FLT1 TEK
3 growth factor binding GO:0019838 9.37 FLT1 TEK
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.13 ANGPT1 EGFR TEK
5 transmembrane signaling receptor activity GO:0004888 9.02 EGFR
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 EGFR FLT1 TEK

Sources for Placenta Accreta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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