MCID: PLC001
MIFTS: 44

Placenta Accreta

Categories: Fetal diseases

Aliases & Classifications for Placenta Accreta

MalaCards integrated aliases for Placenta Accreta:

Name: Placenta Accreta 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4744
MeSH 44 D010921
NCIt 50 C26856
SNOMED-CT 67 70129008
ICD10 32 O43.21
UMLS 70 C0032044

Summaries for Placenta Accreta

Disease Ontology : 12 A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

MalaCards based summary : Placenta Accreta is related to placenta praevia and placental abruption. An important gene associated with Placenta Accreta is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Progesterone and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Placenta Accreta

Diseases related to Placenta Accreta via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 placenta praevia 32.6 PGF PAPPA OXT
2 placental abruption 30.5 PGF PAPPA FLT1
3 severe pre-eclampsia 30.4 VEGFA PGF PAPPA
4 adenomyosis 30.4 VEGFA OXT CDH1
5 gestational trophoblastic neoplasm 30.4 PGF PAPPA OXT AFP
6 chorioamnionitis 30.3 VEGFA OXT FLT1
7 arteriovenous malformation 30.2 VEGFA TEK ANGPT2 ANGPT1
8 ectopic pregnancy 30.2 VEGFA PGF PAPPA FLT1 AFP
9 eclampsia 30.2 VEGFA PGF PAPPA OXT FLT1
10 peripartum cardiomyopathy 30.1 VEGFA PGF FLT1
11 placenta disease 30.1 VEGFA PGF PAPPA OXT FLT1 AFP
12 limb ischemia 29.6 VEGFA TEK SERPINE1 PGF KDR ANGPT2
13 pre-eclampsia 29.5 VEGFA SERPINE1 PGF PAPPA OXT KDR
14 macular degeneration, age-related, 1 29.4 VEGFA TEK PGF KDR FLT1 ANGPT2
15 pulmonary hypertension 29.2 VEGFA TEK SERPINE1 KDR ANGPT1
16 diabetes mellitus 28.4 VEGFA SERPINE1 PGF PAPPA KDR FLT1
17 placental insufficiency 28.3 VEGFA TEK SERPINE1 PGF PAPPA KDR
18 disseminated intravascular coagulation 10.5
19 endometritis 10.4
20 asherman's syndrome 10.4
21 triploidy 10.3 PAPPA AFP
22 intermediate malignant teratoma 10.3 PAPPA AFP
23 leiomyoma 10.3
24 amenorrhea 10.3
25 pulmonary embolism 10.3
26 chromosomal triplication 10.3 PAPPA AFP
27 non-gestational ovarian choriocarcinoma 10.3 TEK AFP
28 pyogenic granuloma 10.3 TEK ANGPT2
29 flying phobia 10.3 OXT AFP
30 toxic shock syndrome 10.3
31 uterine inversion 10.3
32 47,xyy 10.3
33 renal pelvis adenocarcinoma 10.3 CDH1 AFP
34 vaginal adenoma 10.3 PGF OXT
35 vaginal benign neoplasm 10.2 PGF OXT
36 patau syndrome 10.2 PGF PAPPA AFP
37 myoma 10.2
38 choriocarcinoma 10.2
39 microcystic meningioma 10.2 VEGFA FLT1
40 preretinal fibrosis 10.2 VEGFA ANGPT2
41 severe nonproliferative diabetic retinopathy 10.2 VEGFA PGF
42 persistent fetal circulation syndrome 10.2 VEGFA PGF OXT
43 neonatal anemia 10.2 PGF PAPPA FLT1
44 reproductive organ benign neoplasm 10.2 VEGFA OXT AFP
45 glomeruloid hemangioma 10.1 VEGFA FLT1
46 leiomyoma, uterine 10.1
47 hydatidiform mole, recurrent, 1 10.1
48 preterm premature rupture of the membranes 10.1
49 cardiac arrest 10.1
50 thrombosis 10.1

Graphical network of the top 20 diseases related to Placenta Accreta:



Diseases related to Placenta Accreta

Symptoms & Phenotypes for Placenta Accreta

MGI Mouse Phenotypes related to Placenta Accreta:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.33 ANGPT1 ANGPT2 BDKRB2 CDH1 CTSV DOCK4
2 homeostasis/metabolism MP:0005376 10.25 AFP ANGPT1 ANGPT2 BDKRB2 CDH1 CTSV
3 mortality/aging MP:0010768 10.17 AFP ANGPT1 ANGPT2 BDKRB2 CDH1 CTSV
4 integument MP:0010771 10.11 ANGPT2 BDKRB2 CDH1 CTSV KDR OXT
5 embryo MP:0005380 10.09 ANGPT1 CDH1 CTSV FLT1 KDR PGF
6 normal MP:0002873 9.76 BDKRB2 CDH1 FLT1 KDR PAPPA TDGF1
7 neoplasm MP:0002006 9.73 AFP CDH1 DOCK4 PGF SERPINE1 VEGFA
8 reproductive system MP:0005389 9.61 AFP ANGPT2 BDKRB2 CDH1 CTSV FLT1
9 vision/eye MP:0005391 9.28 ANGPT1 ANGPT2 CTSV FLT1 KDR PGF

Drugs & Therapeutics for Placenta Accreta

Drugs for Placenta Accreta (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved 57-83-0 5994
2
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
3
Methylene blue Approved, Investigational 61-73-4
4
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
5 Vasopressins
6 Arginine Vasopressin
7 Hormones
8 Estrogens

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study (TAPPAS): A Randomized, Placebo-controlled Double Blind Trial Completed NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
2 Management of Placenta Accreta Spectrum Recruiting NCT04609527 Phase 2, Phase 3
3 Tranexamic Acid in Adherent Placenta (TAP), a Randomized Clinical Trial Withdrawn NCT02329756 Phase 3 Tranexamic Acid (TXA);Sodium Chloride 0.9%
4 Study of Peripartum Hysterectomy for Maternal Hemorrhage Completed NCT01285258 Phase 2
5 is There Any Superior Benefit of Multidisciplinary Team in Management of Placenta Accreta Unknown status NCT03372538
6 Antenatal Diagnosis of Placental Attachment Disorders Unknown status NCT02442518
7 Diagnostic Accuracy of Doppler Ultrasound and Role of Uterine Artery Doppler in Cases of Placenta Accreta Unknown status NCT03530475
8 Incidence of Placenta Accreta & it's Complications in Cases of Previous Cesarean With Placenta Previa Anterior Unknown status NCT02606474
9 Comparative Study Between Intraoperative Ureteric Dissection and Preoperative Ureteric Stenting in Women With Abnormally Invasive Placenta Unknown status NCT03763916
10 Predictive Value of Cell-free Fetal DNA Concentration in the Maternal Plasma for Abnormal Placental Invasion in Cases of Placenta Previa. Unknown status NCT03638024
11 Comparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar Unknown status NCT03437291
12 Preplacental Delivery Intervention for Uterine Conservation Protocol: a Novel Approach for Management of Placenta Accreta Unknown status NCT03273569
13 Bilateral Internal Iliac Artery Ligation Before Cesarean Hysterectomy : A Randomized Controlled Trial Unknown status NCT03129035
14 Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum With Intravenous Versus Topical Tranexamic Acid: A Double-blind Randomized Controlled Trial Unknown status NCT03570710 intravenous tranexamic acid;Topical tranexamic acid;Normal saline
15 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta in a High Risk Population Unknown status NCT02784886
16 Fertility Post Preservative Cesarean Section and Uterine Artery Embolization Completed NCT02821702
17 Tourniquet on the Low Segment of the Uterus Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta: Old But Gold Completed NCT03707132
18 Optimierung Der Uterotomie-Wundheilung Nach Re-Sectio Caesarea Completed NCT02703519
19 Placenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population Completed NCT02302573 contast-enhanced ultrasound with sonovue
20 Accuracy of Placenta Accreta Index in Diagnosing Placenta Accreta Spectrum: A Prospective Study Completed NCT04314791
21 New Surgical Technique To Control Postpartum Hemorrhage Due To Placenta Accreta Completed NCT03241849
22 Early Prediction of Placenta Accreta by 2 Dimensional Transvaginal Ultrasound and Color Doppler Completed NCT03032770
23 Conservative Surgical Novel Technique of Placenta Accreta in Menoufia University Hospital Completed NCT04161521
24 Placenta Accreta; A Vision for Conservative Surgery Completed NCT04427592
25 Risk Factors for Occurrence of Placenta Accrete Spectrum Following Primary Cesarean Delivery Completed NCT04264169
26 TUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques Completed NCT02712099
27 Surgical Management of Placenta Accreta a Three Year Experience at King Hussein Medical Center Completed NCT03668795
28 Clinical Situations at High Risk of Placenta Accreta / Percreta: Impact of Diagnostic Methods and Management on Maternal Morbidity. Completed NCT02010229
29 Obstetric Hysterectomy Versus Conservative Surgery for Management of Patients With Morbidly Adherent Placenta as Regard Maternal Morbidity and Mortality Completed NCT03327818
30 Balloon Catheter for Occlusion of the Pelvic Vasculature as an Adjuvant Therapy in Cases of Placenta Accreta Completed NCT01373255
31 Evaluation of the Efficacy of Transverse B-Lynch in Management of Placenta Accreta Completed NCT02943421
32 Internal Iliac Artery Ligation and Abnormally Invasive Placenta Completed NCT02728232
33 Long Term Comparison of Double Layer Continuously Locked Closure of Uterine Incision in Cesarean Section Versus Double Layer Purse String Closure (Turan Technique): A Prospective Randomized Study Completed NCT01289262
34 The Effectiveness of Double Incision Technique in Uterus Preserving Surgery for Placenta Percreta Completed NCT02702024
35 the Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta Completed NCT02966197
36 The Use of Thoracic Fluid Content as a Guide for 6% HES Infusion During Hypervolemic Hemodilution in Patients With Placenta Accreta. A Randomized Controlled Trial. Recruiting NCT04689516
37 The Efficacy of Ultrasound in Predicting Operative Findings and Co-morbidities in Cesarean Section Among Cases of Placenta Accreta Recruiting NCT03286998
38 Conservative Surgery for Abnormally Invasive Placenta: A New Technique Recruiting NCT04193618
39 MRI for the Diagnosis of Placenta Accreta Spectrum Recruiting NCT04151979
40 Gray-scale , Colour Doppler Ultrasound and Magnetic Resonance Imaging for Diagnosis of Placenta Accreta Recruiting NCT03813212
41 The Role of Galectin-3 in the Pathogenesis and Prediction of Placenta Accreta Recruiting NCT04573452
42 Detection of Placenta Accreta by Means of Volatile Organic Compounds in Exhaled Women Breath. A Prospective Case Control Study. Recruiting NCT03947047
43 Comparison of Continuous Non-Invasive Arterial Blood Pressure to Invasive Arterial Blood Pressure Measurement in Pregnant Women With Placenta Accreta Recruiting NCT04671680
44 Cervico-Isthmic Compression Suture Versus Anterior Wall Uterine Resection in Cases of Morbidly Adherent Anterior Situated Placenta Recruiting NCT04579172
45 Plasma Concentration of Biological Markers in Placenta Spectrum Recruiting NCT04525534
46 The Implication of Placental Netrin-1 Receptor DCC in the Pathophysiology of Placenta Accreta Recruiting NCT04683562
47 Placenta Accreta Spectrum International Database (PAS-ID): Project Protocol Recruiting NCT04384510
48 Validity of Internal Iliac Artery Ligation With Cervico Isthmic Compression Suture During Conservative Management of Placenta Accreta Spectrum Recruiting NCT04593303
49 Creatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Morbidly Adherent Placenta Recruiting NCT03224780
50 Comparison of N&H Sandwich Technique and Cesarean Hysterectomy in Management of Placenta Accreta Spectrum: A Randomized Controlled Trial Recruiting NCT03701386

Search NIH Clinical Center for Placenta Accreta

Cochrane evidence based reviews: placenta accreta

Genetic Tests for Placenta Accreta

Anatomical Context for Placenta Accreta

MalaCards organs/tissues related to Placenta Accreta:

40
Placenta, Uterus, Heart, Thyroid, Cervix, Endothelial, Whole Blood

Publications for Placenta Accreta

Articles related to Placenta Accreta:

(show top 50) (show all 1839)
# Title Authors PMID Year
1
Comment on "The effectiveness of prophylactic internal iliac artery balloon occlusion in the treatment of patients with pernicious placenta previa coexisting with placenta accreta". 61
31315487 2021
2
Efficacy of targeted screening and proactive management for placenta accreta spectrum disorder in routine clinical settings. 61
33326611 2021
3
Persistent hypoxia induced autophagy leading to invasiveness of trophoblasts in placenta accreta. 61
31269830 2021
4
What we know about placenta accreta spectrum (PAS). 61
33601317 2021
5
Obstetrical outcome after B-Lynch sutures and ligation of uterine arteries: A case report. 61
33777709 2021
6
Previous preterm cesarean delivery and risk of uterine rupture in subsequent trial of labor-a national cohort study. 61
33002499 2021
7
Caesarean hysterectomy in a patient with placenta accreta spectrum disorders. 61
33731394 2021
8
Developing a database for multicenter evaluation of placenta accreta spectrum. 61
33811336 2021
9
When a rare condition creates a scientific society: The history of the International Society for Placenta Accreta Spectrum (IS-PAS). 61
33811334 2021
10
Do all patients with placenta accreta spectrum require endovascular balloons? 61
33785464 2021
11
Management of pregnancies complicated by placenta accreta spectrum utilizing a multidisciplinary care team in a rural state. 61
33769169 2021
12
Placenta accreta spectrum-a catastrophic situation in obstetrics. 61
33757280 2021
13
Placenta Accreta Spectrum 2021: Roundtable Discussion. 61
33788320 2021
14
Association of peripartum management and high maternal blood loss at cesarean delivery for placenta accreta spectrum (PAS): A multinational database study. 61
33524163 2021
15
The clinical utility of magnetic resonance imaging as an adjunct to ultrasound in the diagnosis of placenta accreta spectrum disorders. 61
33771092 2021
16
Total vs. supracervical hysterectomy for placenta accreta spectrum disorders. 61
33749489 2021
17
Open versus endovascular REBOA control of blood loss during cesarean delivery in the placenta accreta spectrum: A single-center retrospective case control study. 61
33388487 2021
18
Postpartum unscarred uterine rupture caused by placenta accreta: A case report and literature review. 61
33768894 2021
19
The "rail sign": An ultrasound finding in placenta accreta spectrum indicating deep villous invasion and adverse outcomes. 61
33744177 2021
20
Placenta accreta spectrum disorder: updates on anesthetic and surgical management strategies. 61
33784573 2021
21
Maternal and neonatal outcomes in planned versus emergency cesarean delivery for placenta accreta spectrum: A multinational database study. 61
33713033 2021
22
Performance of antenatal imaging to predict placenta accreta spectrum degree of severity. 61
33811333 2021
23
The modified radical peri-partum caesarean hysterectomy (Soleymani-Alazzam-Collins (SAC) technique): a systematic, safe procedure for the management of severe placenta accreta spectrum (PAS). 61
33716074 2021
24
Transvaginal Color Mapping Ultrasound in the First Trimester Predicts Placenta Accreta Spectrum: A Retrospective Cohort Study. 61
33724510 2021
25
An analysis of maternal-fetal prognosis in patients with placenta accreta. 61
31122093 2021
26
Validation of a scoring system for prediction of obstetric complications in placenta accreta spectrum disorders. 61
33685330 2021
27
The effect prophylactic internal iliac artery balloon occlusion in patients with placenta previa or placental accreta spectrum: a systematic review and meta-analysis. 61
33663536 2021
28
Analysis of clinical features of 231 cases with pernicious placenta previa: A retrospective cohort study. 61
33725977 2021
29
Criteria for placenta accreta spectrum in the International Federation of Gynaecology and Obstetrics classification, and topographic invasion area are associated with massive hemorrhage in patients with placenta previa. 61
33715171 2021
30
The relation between maternal obesity and placenta accreta spectrum: A multinational database study. 61
33811335 2021
31
A rare case of extensive placenta accreta in twin pregnancy after GnRH agonist treatment of adenomyosis. 61
33658071 2021
32
Unexpected placenta accreta spectrum after the use of assisted reproductive technology in women with adenomyomectomy. 61
33731511 2021
33
Quality of life and sexual function after a pregnancy complicated by placenta accreta spectrum. 61
33763885 2021
34
[Pregnancy after the first uterine fribrom embolization procedures in sub-saharian Africa in Côte d'Ivoire]. 61
33677123 2021
35
Midgestational pre-labor spontaneous uterine rupture: a systematic review. 61
33691570 2021
36
Association between Number of Prior Cesareans and Early Preterm Delivery in Women with Abnormal Placentation. 61
32992353 2021
37
First trimester serum PAPP-A is associated with placenta accreta: a retrospective study. 61
33515274 2021
38
A multicenter observational survey of management strategies in 442 pregnancies with suspected placenta accreta spectrum. 61
33483943 2021
39
[Postpartum hemorrhage and need of blood transfusions]. 61
33720382 2021
40
Clusterin and Its Potential Regulatory microRNAs as a Part of Secretome for the Diagnosis of Abnormally Invasive Placenta: Accreta, Increta, and Percreta Cases. 61
33805203 2021
41
Intravoxel incoherent motion MR imaging analysis for diagnosis of placenta accrete spectrum disorders: A pilot feasibility study. 61
33766730 2021
42
Outcome of cesarean scar pregnancy according to gestational age at diagnosis: A systematic review and meta-analysis. 61
33421811 2021
43
Extreme enhanced myometrial vascularity following cesarean scar pregnancy: a new diagnostic entity. 61
33730990 2021
44
Factors Associated with Failure of Bakri Balloon Tamponade for the Management of Postpartum Haemorrhage. Case Series Study and Systematic Review. 61
33800388 2021
45
Management of major obstetric hemorrhage prior to peripartum hysterectomy and outcomes across nine European countries. 61
33719032 2021
46
Clinical Significance of Velamentous Cord Insertion Prenatally Diagnosed in Twin Pregnancy. 61
33546368 2021
47
Maternal age at first cesarean delivery related to adverse pregnancy outcomes in a second cesarean delivery: a multicenter, historical, cross-sectional cohort study. 61
33579220 2021
48
Coronavirus disease 2019 (COVID-19) manifestations during pregnancy in all three trimesters: A case series. 61
33718763 2021
49
Obstetric outcomes for twins from different conception methods - A multicenter cross-sectional study from China. 61
33556189 2021
50
Evaluation of the Tramline Sign in the Prediction of Placenta Accreta Spectrum and Perioperative Outcomes in Anterior Placenta Previa. 61
33556967 2021

Variations for Placenta Accreta

Expression for Placenta Accreta

Search GEO for disease gene expression data for Placenta Accreta.

Pathways for Placenta Accreta

Pathways related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 VEGFA TEK TDGF1 PGF KDR FLT1
2
Show member pathways
13.46 VEGFA TEK TDGF1 PGF KDR FLT1
3
Show member pathways
13.3 TEK TDGF1 PGF KDR FLT1 ANGPT2
4
Show member pathways
13.21 TEK TDGF1 PGF KDR FLT1 CDH1
5
Show member pathways
13.15 VEGFA TEK TDGF1 PGF KDR FLT1
6
Show member pathways
12.86 VEGFA TEK PGF KDR FLT1 ANGPT2
7 12.67 VEGFA TEK PGF KDR FLT1 ANGPT2
8
Show member pathways
12.32 TEK TDGF1 PGF KDR FLT1 CDH1
9
Show member pathways
12.29 VEGFA PGF KDR FLT1
10 12.29 VEGFA KDR FLT1 BDKRB2
11
Show member pathways
12.25 VEGFA KDR FLT1 CDH1
12
Show member pathways
12.25 VEGFA TEK PGF KDR FLT1 DOCK4
13 12.05 TEK KDR FLT1 ANGPT2
14
Show member pathways
11.86 VEGFA KDR FLT1
15 11.79 VEGFA TEK FLT1 ANGPT1
16
Show member pathways
11.78 VEGFA PGF KDR FLT1
17 11.72 TEK TDGF1 KDR FLT1 ANGPT2
18 11.67 VEGFA TEK SERPINE1 FLT1 ANGPT2 ANGPT1
19 11.39 VEGFA KDR FLT1
20 11.3 VEGFA SERPINE1 ANGPT2 ANGPT1
21 11.24 VEGFA SERPINE1 KDR FLT1
22 11.15 VEGFA TDGF1 FLT1
23 10.83 TEK TDGF1 PGF KDR FLT1 CDH1
24
Show member pathways
10.76 VEGFA PGF KDR FLT1
25 10.4 VEGFA TEK KDR FLT1 ANGPT1

GO Terms for Placenta Accreta

Cellular components related to Placenta Accreta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 VEGFA TDGF1 SERPINE1 PGF PAPPA OXT
2 membrane raft GO:0045121 9.56 TEK TDGF1 KDR ANGPT1
3 secretory granule GO:0030141 9.5 VEGFA OXT CTSV
4 extracellular region GO:0005576 9.5 VEGFA TEK TDGF1 SERPINE1 PGF PAPPA
5 microvillus GO:0005902 9.33 TEK CTSV ANGPT1

Biological processes related to Placenta Accreta according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.24 VEGFA TEK TDGF1 RXFP1 PGF OXT
2 multicellular organism development GO:0007275 10.17 VEGFA TEK PGF KDR FLT1 ANGPT2
3 cell differentiation GO:0030154 10.13 VEGFA TDGF1 RXFP1 PGF KDR FLT1
4 positive regulation of cell proliferation GO:0008284 10.07 VEGFA TDGF1 PGF KDR FLT1
5 negative regulation of apoptotic process GO:0043066 10.06 VEGFA TEK TDGF1 KDR ANGPT1
6 extracellular matrix organization GO:0030198 9.96 SERPINE1 RXFP1 KDR CDH1
7 positive regulation of cell migration GO:0030335 9.96 VEGFA TDGF1 KDR FLT1
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.94 VEGFA TEK KDR ANGPT1
9 positive regulation of protein phosphorylation GO:0001934 9.93 VEGFA TEK PGF KDR ANGPT1
10 response to hypoxia GO:0001666 9.92 VEGFA TEK PGF ANGPT2
11 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.88 TEK KDR FLT1 BDKRB2 ANGPT1
12 positive regulation of MAPK cascade GO:0043410 9.87 VEGFA TEK KDR FLT1
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 VEGFA TDGF1 ANGPT1
14 positive regulation of kinase activity GO:0033674 9.82 TEK KDR FLT1
15 response to glucocorticoid GO:0051384 9.81 PAPPA OXT CTSV
16 positive regulation of endothelial cell proliferation GO:0001938 9.81 VEGFA TEK PGF KDR
17 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.8 VEGFA PGF KDR FLT1
18 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 VEGFA TEK KDR FLT1 ANGPT1
19 positive regulation of blood vessel endothelial cell migration GO:0043536 9.79 VEGFA KDR ANGPT1
20 positive chemotaxis GO:0050918 9.76 VEGFA PGF ANGPT1
21 negative regulation of endothelial cell apoptotic process GO:2000352 9.76 TEK SERPINE1 KDR ANGPT1
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.75 VEGFA KDR FLT1
23 positive regulation of focal adhesion assembly GO:0051894 9.73 VEGFA TEK KDR
24 sprouting angiogenesis GO:0002040 9.73 VEGFA TEK PGF ANGPT1
25 cell migration involved in sprouting angiogenesis GO:0002042 9.72 VEGFA TDGF1 KDR
26 induction of positive chemotaxis GO:0050930 9.68 VEGFA PGF
27 positive regulation of positive chemotaxis GO:0050927 9.66 VEGFA KDR
28 regulation of vascular permeability GO:0043114 9.65 TEK BDKRB2
29 positive regulation of endothelial cell migration GO:0010595 9.65 VEGFA TEK TDGF1 KDR ANGPT1
30 vascular wound healing GO:0061042 9.64 VEGFA KDR
31 positive regulation of mast cell chemotaxis GO:0060754 9.62 VEGFA PGF
32 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.61 VEGFA KDR
33 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.6 VEGFA KDR
34 glomerulus vasculature development GO:0072012 9.54 TEK ANGPT2 ANGPT1
35 Tie signaling pathway GO:0048014 9.5 TEK ANGPT2 ANGPT1
36 positive regulation of angiogenesis GO:0045766 9.5 VEGFA TEK SERPINE1 PGF KDR FLT1
37 vascular endothelial growth factor signaling pathway GO:0038084 9.46 VEGFA PGF KDR FLT1
38 angiogenesis GO:0001525 9.23 VEGFA TEK SERPINE1 PGF KDR FLT1

Molecular functions related to Placenta Accreta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 9.5 DOCK4 ANGPT2 ANGPT1
2 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 KDR FLT1
3 signaling receptor binding GO:0005102 9.35 TDGF1 SERPINE1 INSL4 ANGPT2 ANGPT1
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 TEK KDR FLT1
5 vascular endothelial growth factor receptor binding GO:0005172 9.26 VEGFA PGF
6 growth factor binding GO:0019838 8.8 TEK KDR FLT1

Sources for Placenta Accreta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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