MCID: PLC008
MIFTS: 56

Placenta Disease

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Placenta Disease

MalaCards integrated aliases for Placenta Disease:

Name: Placenta Disease 12 15
Pregnancy Complications 44 73
Placenta Disorder 76 53
Placenta Diseases 53 44
Placenta Disorders 73

Classifications:



External Ids:

Disease Ontology 12 DOID:780
ICD10 33 O43 O43.9 O43.90
ICD9CM 35 646.9
SNOMED-CT 68 23288008 90821003

Summaries for Placenta Disease

Disease Ontology : 12 A uterine disease that is located in the placenta.

MalaCards based summary : Placenta Disease, also known as pregnancy complications, is related to antiphospholipid syndrome and placental insufficiency, and has symptoms including hyperemesis gravidarum, morning sickness and late pregnancy bleeding. An important gene associated with Placenta Disease is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. The drugs Hyaluronic acid and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and endothelial, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Ischemic placental disease leads to the attachment of the placenta to the uterine wall to become... more...

Related Diseases for Placenta Disease

Diseases related to Placenta Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 420)
# Related Disease Score Top Affiliating Genes
1 antiphospholipid syndrome 31.9 ANXA5 APOH F3 F5 MTHFR SERPINC1
2 placental insufficiency 31.7 AFP F3 PGF
3 oligohydramnios 31.6 AFP CGA OXT
4 placental abruption 31.6 APOH F5 MTHFR PGF SERPINC1
5 eclampsia 30.6 MTHFR OXT PAPPA PGF SERPINC1
6 thrombophilia 30.5 APOH F3 F5 MTHFR SERPINC1
7 severe pre-eclampsia 30.4 APOH F5 PGF SERPINC1
8 purpura 30.1 APOH F3 IL6 SERPINC1
9 gastroschisis 30.1 F5 IL6 MTHFR
10 teratoma 30.0 AFP CGA CGB3
11 hellp syndrome 30.0 APOH F3 F5 HADHA IL6 MTHFR
12 thrombosis 30.0 APOH F3 F5 MTHFR SERPINC1
13 ectopic pregnancy 29.9 CGA CGB3 CGB7 PAPPA PGF
14 disseminated intravascular coagulation 29.8 F3 F5 SERPINC1
15 pre-eclampsia 29.8 AFP ANXA5 APOH F3 F5 HADHA
16 chromosomal triplication 29.7 AFP CGA CGB3
17 endocarditis 29.7 APOH IL6 SERPINC1
18 thrombophilia due to thrombin defect 29.7 APOH F3 F5 MTHFR SERPINC1
19 sacrococcygeal teratoma 29.7 AFP CGA CGB7
20 gestational trophoblastic neoplasm 29.7 CSH1 CSH2 LGALS1 OXT
21 triploidy 29.6 AFP CGA CGB7 PAPPA
22 rh isoimmunization 29.6 AFP CSH1 CSH2 OXT PNLIP
23 pulmonary embolism 29.5 APOH F3 F5 MTHFR SERPINC1
24 prothrombin deficiency, congenital 29.5 APOH F5 SERPINC1
25 varicose veins 29.5 F5 MTHFR SERPINC1
26 cerebral palsy 29.4 F5 IL6 MTHFR
27 catastrophic antiphospholipid syndrome 29.4 APOH F3 F5 MTHFR
28 thrombocytosis 29.4 F3 IL6 SERPINC1
29 intracranial hypertension 29.3 APOH F3 F5 MTHFR SERPINC1
30 choriocarcinoma 29.3 CGA CGB3 CGB7 CSH1 CSH2
31 budd-chiari syndrome 29.3 APOH F3 F5 MTHFR SERPINC1
32 down syndrome 29.2 AFP CGB3 CGB7 MTHFR PAPPA
33 vascular disease 29.2 APOH F3 F5 IL6 MTHFR SERPINC1
34 hepatic infarction 29.1 APOH F3 HADHA MTHFR OXT SERPINC1
35 myocardial infarction 28.9 ANXA5 F3 F5 IL6 MTHFR PAPPA
36 chorioamnionitis 10.9
37 placenta praevia 10.9
38 placenta accreta 10.9
39 polyhydramnios 10.9
40 diethylstilbestrol syndrome 10.9
41 inferior vena cava interruption 10.3 F5 MTHFR
42 may-thurner syndrome 10.3 APOH F5
43 ovarian mixed germ cell neoplasm 10.3 AFP CGA
44 polyembryoma 10.3 AFP CGA
45 acanthamoeba keratitis 10.3 APOH F5
46 amaurosis fugax 10.3 F5 MTHFR
47 intermediate malignant teratoma 10.3 AFP PAPPA
48 tuberculous epididymitis 10.3 AFP CGB3
49 diabetes mellitus 10.3
50 acquired hemophilia 10.3 F3 F5

Graphical network of the top 20 diseases related to Placenta Disease:



Diseases related to Placenta Disease

Symptoms & Phenotypes for Placenta Disease

UMLS symptoms related to Placenta Disease:


hyperemesis gravidarum, morning sickness, late pregnancy bleeding, maternal fever, intrapartum fever

MGI Mouse Phenotypes related to Placenta Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.93 CGA DIO3 F3 F5 HADHA IL6
2 homeostasis/metabolism MP:0005376 9.83 AFP APOH CGA DIO3 F3 F5
3 liver/biliary system MP:0005370 9.23 AFP DIO3 F5 HADHA IL6 MTHFR

Drugs & Therapeutics for Placenta Disease

Drugs for Placenta Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 120)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-56-6 439302 53477758
3
Carbetocin Approved, Investigational Phase 4,Phase 3 37025-55-1 71715 16681432
4
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
5
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
6
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
7
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
8 tannic acid Approved Phase 4
9
Peppermint oil Approved, Investigational Phase 4 8006-90-4
10
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
11
Ethanol Approved Phase 4 64-17-5 702
12 Coconut Approved Phase 4
13
Peppermint Approved Phase 4
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
15
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
16
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
17
leucovorin Approved Phase 4 58-05-9 6006 143
18
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1197-18-8 5526
19
Misoprostol Approved Phase 4,Phase 2,Phase 1,Not Applicable 59122-46-2 5282381
20
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
22 Adjuvants, Immunologic Phase 4
23 Immunologic Factors Phase 4
24 Protective Agents Phase 4,Phase 1,Phase 2
25 Viscosupplements Phase 4
26 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Coagulants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
30 Clindamycin palmitate Phase 4,Not Applicable
31 Gentamicins Phase 4,Phase 2,Phase 3,Not Applicable
32 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
33 Clindamycin phosphate Phase 4,Not Applicable
34 Antitubercular Agents Phase 4,Phase 2,Phase 3,Not Applicable
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
38 Antirheumatic Agents Phase 4,Phase 2
39 Analgesics, Non-Narcotic Phase 4,Phase 2
40 Platelet Aggregation Inhibitors Phase 4,Phase 2
41 Cyclooxygenase Inhibitors Phase 4,Phase 2
42 Antipyretics Phase 4,Phase 2
43 Anti-Inflammatory Agents Phase 4,Phase 2
44 Fibrinolytic Agents Phase 4,Phase 2
45 Vasodilator Agents Phase 4,Phase 3,Phase 2
46 Anti-Infective Agents, Urinary Phase 4
47 Renal Agents Phase 4
48 Fanasil, pyrimethamine drug combination Phase 4
49 Vitamin B9 Phase 4
50 Antimalarials Phase 4

Interventional clinical trials:

(show top 50) (show all 139)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion Unknown status NCT02868437 Phase 4
2 Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
3 Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
4 Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination Completed NCT02969447 Phase 4 Administration of 10 units of intra venous oxytocin after fetal expulsion
5 GOT-IT Trial: Glyceryl Trinitrate for Retained Placenta Completed NCT02085213 Phase 4 Glyceryl Trinitrate;Matched Placebo
6 Intravenous Nitroglycerin for Retained Placenta Extraction: a Multicenter Study Completed NCT00707928 Phase 4 nitroglycerine
7 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4 Sulfadoxine-pyrimethamine (Fansidar)
8 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
9 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Recruiting NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
10 Carbetocin Versus Misoprostol in Cases With Placenta Previa After C.S. Recruiting NCT02277041 Phase 4 Carbetocin;Misoprostol
11 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
12 Intrapartum Fever: Antibiotics Versus no Treatment Withdrawn NCT03168178 Phase 4 Standard Antibiotic Treatment
13 Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial Unknown status NCT02303418 Phase 3 Carbetocin;Oxytocin
14 Low Weight Heparin prOphylaxis for Placental‐Mediated Complications of PrEgnancy Completed NCT01388322 Phase 3 Enoxaparin
15 Tranexamic Acid Use in Elective Cesarean Section for Women With Placenta Previa Completed NCT03060889 Phase 3 Tranexamic acid
16 Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Completed NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
17 the Treatment of Postpartum Hemorrhage Due to Placenta Previa Complete Centralis Completed NCT02157441 Phase 2, Phase 3
18 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
19 Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3 Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
20 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
21 Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa Not yet recruiting NCT03542552 Phase 3 Magnesium Sulfate;Nifedipine
22 Tranexamic Acid in Adherent Placenta (TAP) Withdrawn NCT02329756 Phase 3 Tranexamic Acid (TXA);Sodium Chloride 0.9%
23 Cerclage for Prevention on Preterm Birth in Women With Placenta Previa Withdrawn NCT01442207 Phase 3
24 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
25 Intramuscular Hydroxyprogesterone Caproate and Placenta Previa Completed NCT03130504 Phase 2 17α hydroxy progesterone caproate
26 Tocolytic Therapy in Conservative Management of Symptomatic Placenta Previa Completed NCT00620724 Phase 2 Placebo;Nifedipine
27 Efficacy Study of Random Placenta Margin Incision to Treat Complete Placenta Previa Completed NCT02695069 Phase 2
28 Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa Completed NCT02688127 Phase 1, Phase 2 Tranexamic Acid
29 The Foley's Catheter Balloon to the Bleeding From Placenta Previa Completed NCT02640885 Phase 2
30 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
31 Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio) Completed NCT00724594 Phase 1, Phase 2 N-acetylcysteine;Control
32 Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy Completed NCT00153517 Phase 2 oral versus vaginal metronidazole
33 Progesterone in Patients With Placenta Previa Recruiting NCT03633175 Phase 2 Vaginal progesterone
34 Intraumbilical Oxytocin Versus Placental Cord Drainage in the Management of 3rd Stage of Labor Recruiting NCT03395730 Phase 2 Intraumbilical vein injection oxytocin
35 Two Different Regimens of Misoprostol in Retained Placenta Recruiting NCT02704780 Phase 2 Misoprostol
36 Bakri Balloon in Placenta Previa Not yet recruiting NCT02694341 Phase 2
37 Intraumbilical Misoprostol in Retained Placenta Completed NCT01840813 Phase 1 Misoprostol;Normal saline
38 The Correlation Between Clinical Diagnosis of Retained Placenta And Histology Unknown status NCT02927730
39 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta Unknown status NCT02784886
40 Placenta Accreta&Its Complications in Placenta Previa Cases Unknown status NCT02606474
41 Antenatal Diagnosis of Placental Attachment Disorders Unknown status NCT02442518
42 ADAMTS,Proteoglycan and Oxidant / Antioxidant Enzyme Levels of Placenta Previa Totalis (Accreta, Increta, Percreta). Unknown status NCT02270593
43 Maternal Plasmatic Regulatory T Cells and Th17 as Possible Diagnosis Markers of Acute Chorioamnionitis Unknown status NCT01610258 Not Applicable
44 Treatment of Chorioamnionitis After Delivery Unknown status NCT00814905 Not Applicable saline;ampicillin gentamicin;Ampicillin gentamicin clindamycin;ampicillin gentamicin clindamycin
45 Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical Chorioamnionitis Unknown status NCT00299637
46 The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta Unknown status NCT02590484 Not Applicable
47 Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial Unknown status NCT01945450 Not Applicable Antibiotic prophylaxis;Ampicillin;Gentamycin;Clindamycin
48 Transperineal Ultrasound to Assess the Progress of Labour Unknown status NCT02430038
49 Early Identification of Brain Insult in Chorioamnionitis Unknown status NCT01778725
50 Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity Unknown status NCT00573118

Search NIH Clinical Center for Placenta Disease

Cochrane evidence based reviews: placenta diseases

Genetic Tests for Placenta Disease

Anatomical Context for Placenta Disease

MalaCards organs/tissues related to Placenta Disease:

41
Placenta, Ovary, Endothelial, Heart, Testes, Liver, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Placenta Disease:

19
The Placenta

Publications for Placenta Disease

Articles related to Placenta Disease:

(show top 50) (show all 626)
# Title Authors Year
1
Inherited Thrombophilia and Pregnancy Complications: Should We Test? ( 29864774 )
2018
2
Ex Vivo Dual Perfusion of the Human Placenta: Disease Simulation, Therapeutic Pharmacokinetics and Analysis of Off-Target Effects. ( 29197003 )
2018
3
Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies. ( 29405972 )
2018
4
Assessment of M2/ANXA5 haplotype as a risk factor in couples with placenta-mediated pregnancy complications. ( 28900802 )
2018
5
Correction to: Prospective cohort study of pregnancy complications and birth outcomes in women with asthma. ( 30511190 )
2018
6
Maternal Asthma, Pregnancy Complications and Offspring Wheeze: Untangling the Web. ( 30183328 )
2018
7
Pregnancy complications and adverse outcomes in placental chorioangioma: a retrospective cohort analysis. ( 30431372 )
2018
8
Pregnancy complications, treatment characteristics and birth outcomes in women with atopic dermatitis in Denmark. ( 30242910 )
2018
9
Pregnancy Complications in a-Thalassemia (Hemoglobinopathy H): A Case Study. ( 29992068 )
2018
10
Pregnancy Complications Associated With Maternal Hypothyroidism: A Systematic Review. ( 29701867 )
2018
11
Risk of pregnancy complications and adverse birth outcomes after maternal A(H1N1)pdm09 influenza: a Norwegian population-based cohort study. ( 30348103 )
2018
12
Pregnancy complications in infertile patients with polycystic ovary syndrome: updated evidence. ( 29644330 )
2018
13
Risk of Preeclampsia and Pregnancy Complications in Women With a History of Acute Kidney Injury. ( 29915020 )
2018
14
The first trimester aneuploidy biochemical markers in IVF/ICSI patients have no additional benefit compared to spontaneous conceptions in the prediction of pregnancy complications. ( 29216009 )
2018
15
Management of pregnancy complications in type 2N von Willebrand disease associated to a novel mutation. ( 29656540 )
2018
16
Increased Risk of Pregnancy Complications After Stroke: The FUTURE Study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation). ( 29511129 )
2018
17
Community Health Workers and Use of mHealth: Improving Identification of Pregnancy Complications and Access to Care in the Dominican Republic. ( 28578606 )
2018
18
Maternal long chain polyunsaturated fatty acid status and pregnancy complications. ( 28888333 )
2018
19
Pregnancy Complications and Wheezing and Asthma in Childhood. ( 29064265 )
2018
20
An Early Pregnancy Unit in the United States: An Effective Method for Evaluating First-Trimester Pregnancy Complications. ( 29119588 )
2018
21
Relationship Between Pregnancy Complications and Psychiatric Disorders: A Population-Based Study With a Matched Control Group. ( 29137553 )
2018
22
Placental exosomes: A proxy to understand pregnancy complications. ( 29193463 )
2018
23
Body mass index at 11-13 weeks' gestation and pregnancy complications in a Southern Chinese population: a retrospective cohort study. ( 29301455 )
2018
24
Matrix metalloproteinase and tissue inhibitors of metalloproteinases gene polymorphisms in disorders that influence fertility and pregnancy complications: A systematic review and meta-analysis. ( 29309889 )
2018
25
Pregnancy complications in Brazilian puerperal women treated in the public and private health systems. ( 29319740 )
2018
26
Associations of the dietary approaches to stop hypertension (DASH) diet with pregnancy complications in Project Viva. ( 29339829 )
2018
27
Bias from restricting to live births when estimating effects of prescription drug use on pregnancy complications: A simulation. ( 29341340 )
2018
28
A novel rodent model of pregnancy complications associated with genetically determined angiotensin-converting enzyme (ACE) activity. ( 29360395 )
2018
29
Association between intimate partner violence during pregnancy and maternal pregnancy complications among recently delivered women in Bangladesh. ( 29417590 )
2018
30
Multivariate analysis of cytokine profiles in pregnancy complications. ( 29450942 )
2018
31
Effect of counseling quality on anxiety, grief, and coping after second-trimester abortion for pregnancy complications. ( 29477632 )
2018
32
Immune activation by nucleic acids: A role in pregnancy complications. ( 29479732 )
2018
33
Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications. ( 29497952 )
2018
34
Tuberculosis during pregnancy in the United States: Racial/ethnic disparities in pregnancy complications and in-hospital death. ( 29579086 )
2018
35
Are Anti-β2 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case-Control Study. ( 29635655 )
2018
36
Hypertensive pregnancy complications in women with epilepsy and antiepileptic drugs: a population-based cohort study of first pregnancies in Norway. ( 29691249 )
2018
37
Transfer of polycyclic aromatic hydrocarbons from mother to fetus in relation to pregnancy complications. ( 29702403 )
2018
38
The Influence of Maternal Obesity on Pregnancy Complications and Neonatal Outcomes in Diabetic and Nondiabetic Women. ( 29720745 )
2018
39
Pregnancy complications and subsequent breast cancer risk in the mother: a Nordic population-based case-control study. ( 29752724 )
2018
40
Do Young Women Need Treatment for Hypertension After Pregnancy Complications? ( 29755037 )
2018
41
Neonatal autonomic function after pregnancy complications and early cardiovascular development. ( 29795212 )
2018
42
Prospective cohort study of pregnancy complications and birth outcomes in women with asthma. ( 29797075 )
2018
43
Interbirth Interval and Pregnancy Complications and Outcomes: Findings from the Pregnancy Risk Assessment Monitoring System. ( 29800502 )
2018
44
Husband's role in handling pregnancy complications in Mangochi District, Malawi: A call for increased focus on community level male involvement. ( 29804778 )
2018
45
The first-trimester of pregnancy - A window of opportunity for prediction and prevention of pregnancy complications and future life. ( 29852233 )
2018
46
Utility of metabolic profiling of serum in the diagnosis of pregnancy complications. ( 29884304 )
2018
47
Gestational Weight Gain and Pregnancy Complications in a High-Risk, Racially and Ethnically Diverse Population. ( 29920144 )
2018
48
Counseling and Knowledge of Danger Signs of Pregnancy Complications in Haiti, Malawi, and Senegal. ( 29936656 )
2018
49
Pregnancy complications following fertility treatment-disentangling the role of multiple gestation. ( 29939263 )
2018
50
The Association of Vitamin D Levels with Common Pregnancy Complications. ( 29976852 )
2018

Variations for Placenta Disease

Expression for Placenta Disease

Search GEO for disease gene expression data for Placenta Disease.

Pathways for Placenta Disease

Pathways related to Placenta Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 AFP CGA IL6

GO Terms for Placenta Disease

Cellular components related to Placenta Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 AFP ANXA5 APOH CGA CGB3 CGB7
2 endoplasmic reticulum lumen GO:0005788 9.65 AFP F5 IL6 LGALS1 SERPINC1
3 collagen-containing extracellular matrix GO:0062023 9.55 ANXA5 APOH F3 LGALS1 SERPINC1
4 extracellular space GO:0005615 9.53 AFP APOH CGA CGB3 CGB7 CSH1

Biological processes related to Placenta Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.87 HADHA LGALS1 MTHFR PGF
2 platelet degranulation GO:0002576 9.77 ANXA5 APOH F5
3 post-translational protein modification GO:0043687 9.72 AFP F5 IL6 LGALS1 SERPINC1
4 female pregnancy GO:0007565 9.71 OXT PAPPA PGF
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 CSH1 CSH2 IL6
6 blood coagulation GO:0007596 9.67 ANXA5 F3 F5 SERPINC1
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CSH1 CSH2 IL6
8 peptide hormone processing GO:0016486 9.58 CGA CGB3
9 female gamete generation GO:0007292 9.58 CGB3 CGB7
10 response to glucocorticoid GO:0051384 9.58 IL6 OXT PAPPA
11 animal organ development GO:0048513 9.56 CSH1 CSH2
12 negative regulation of blood coagulation GO:0030195 9.55 ANXA5 APOH
13 regulation of blood coagulation GO:0030193 9.52 APOH SERPINC1
14 growth hormone receptor signaling pathway GO:0060396 9.49 CSH1 CSH2
15 positive regulation of growth GO:0045927 9.48 CSH1 CSH2
16 thyroid hormone generation GO:0006590 9.46 CGA DIO3
17 hemostasis GO:0007599 9.46 ANXA5 F3 F5 SERPINC1
18 positive regulation of JAK-STAT cascade GO:0046427 9.43 CSH1 CSH2 IL6
19 cellular protein metabolic process GO:0044267 9.43 AFP F5 IL6 LGALS1 PAPPA SERPINC1
20 regulation of signaling receptor activity GO:0010469 9.23 CGA CGB3 CGB7 CSH1 CSH2 IL6

Molecular functions related to Placenta Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.5 ANXA5 APOH F3
2 growth factor activity GO:0008083 9.46 CSH1 CSH2 IL6 PGF
3 growth hormone receptor binding GO:0005131 9.26 CSH1 CSH2
4 heparin binding GO:0008201 9.26 ANXA5 APOH PGF SERPINC1
5 hormone activity GO:0005179 9.1 CGA CGB3 CGB7 CSH1 CSH2 OXT

Sources for Placenta Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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