MCID: PLC009
MIFTS: 39

Placenta Praevia

Categories: Fetal diseases

Aliases & Classifications for Placenta Praevia

Summaries for Placenta Praevia

Disease Ontology : 12 A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.

MalaCards based summary : Placenta Praevia, also known as placenta previa, is related to placental abruption and placenta accreta. An important gene associated with Placenta Praevia is NDUFA12 (NADH:Ubiquinone Oxidoreductase Subunit A12). The drugs Oxytocin and Carbetocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and cervix, and related phenotype is growth/size/body region.

Wikipedia : 76 Placenta praevia is when the placenta attaches inside the uterus but near or over the cervical opening.... more...

Related Diseases for Placenta Praevia

Diseases related to Placenta Praevia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 placental abruption 10.6
2 placenta accreta 10.5
3 endometriosis 10.3
4 leiomyoma 10.2
5 eclampsia 10.2
6 leiomyoma, uterine 10.1
7 severe pre-eclampsia 10.1
8 afibrinogenemia 10.1
9 hydatidiform mole, recurrent, 1 10.1
10 sarcoma 10.1
11 thymoma 10.1
12 gestational trophoblastic neoplasm 10.1
13 malignant hyperthermia 10.1
14 uterine sarcoma 10.1
15 blue rubber bleb nevus 10.0
16 systemic lupus erythematosus 10.0
17 marfan syndrome 10.0
18 varicose veins 10.0
19 factor v deficiency 10.0
20 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.0
21 respiratory distress syndrome in premature infants 10.0
22 lung cancer susceptibility 3 10.0
23 hydrops fetalis, nonimmune, and/or atrial septal defect 10.0
24 cerebral palsy 10.0
25 diabetes mellitus 10.0
26 hepatitis 10.0
27 hepatitis b 10.0
28 newborn respiratory distress syndrome 10.0
29 ectopic pregnancy 10.0
30 thrombosis 10.0
31 pre-eclampsia 10.0
32 neonatal anemia 10.0
33 von willebrand's disease 10.0
34 periventricular leukomalacia 10.0
35 adenocarcinoma 10.0
36 placental site trophoblastic tumor 10.0
37 trophoblastic neoplasm 10.0
38 pyoderma 10.0
39 infertility 10.0
40 placenta disease 10.0
41 pyoderma gangrenosum 10.0
42 lupus erythematosus 10.0
43 pulmonary embolism 10.0
44 asherman's syndrome 10.0
45 fetal edema 10.0
46 hydrops fetalis 10.0
47 leukomalacia 10.0
48 respiratory distress syndrome, infant 10.0

Graphical network of the top 20 diseases related to Placenta Praevia:



Diseases related to Placenta Praevia

Symptoms & Phenotypes for Placenta Praevia

MGI Mouse Phenotypes related to Placenta Praevia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.02 AATF EPHA1 FOXK1 HADHA HCCS

Drugs & Therapeutics for Placenta Praevia

Drugs for Placenta Praevia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 4,Phase 3 50-56-6 439302 53477758
2
Carbetocin Approved, Investigational Phase 4,Phase 3 37025-55-1 71715 16681432
3
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1197-18-8 5526
4
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
5
Misoprostol Approved Phase 4 59122-46-2 5282381
6 Oxytocics Phase 4,Phase 3
7 Antifibrinolytic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
8 Coagulants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Hemostatics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Antacids Phase 4
11 Anti-Ulcer Agents Phase 4
12 Gastrointestinal Agents Phase 4
13
Nifedipine Approved Phase 3,Phase 2 21829-25-4 4485
14
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
15 Hormones Phase 3,Phase 2,Not Applicable
16 Hormone Antagonists Phase 3,Phase 2,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
18 Anesthetics Phase 3
19 Progestins Phase 3,Phase 2,Not Applicable
20 Vasodilator Agents Phase 3,Phase 2
21 calcium channel blockers Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 3,Not Applicable
23 Tocolytic Agents Phase 3,Phase 2
24 Central Nervous System Depressants Phase 3
25 Calcium, Dietary Phase 3,Phase 2
26 Analgesics Phase 3,Not Applicable
27 Anti-Arrhythmia Agents Phase 3
28 Anticonvulsants Phase 3
29
Progesterone Approved, Vet_approved Phase 2,Not Applicable 57-83-0 5994
30 Estrogen Antagonists Phase 2,Not Applicable
31 Estrogen Receptor Antagonists Phase 2,Not Applicable
32 Estrogens Phase 2,Not Applicable
33 11-hydroxyprogesterone Phase 2,Not Applicable
34 17-alpha-hydroxy-progesterone caproate Phase 2,Not Applicable
35 Caproate Phase 2,Not Applicable
36
Letrozole Approved, Investigational Not Applicable 112809-51-5 3902
37
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
38
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
39
Menotropins Approved Not Applicable 61489-71-2, 9002-68-0 5360545
40
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
41 Deslorelin Investigational, Vet_approved Not Applicable 57773-65-6
42 Antioxidants
43 Protective Agents
44 Steroid Synthesis Inhibitors Not Applicable
45 Aromatase Inhibitors Not Applicable
46 Cyclooxygenase Inhibitors Not Applicable
47 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
48 Analgesics, Non-Narcotic Not Applicable
49 Antirheumatic Agents Not Applicable
50 Platelet Aggregation Inhibitors Not Applicable

Interventional clinical trials:

(show top 50) (show all 87)
# Name Status NCT ID Phase Drugs
1 Carbetocin Versus Misoprostol in Cases With Placenta Previa After C.S. Recruiting NCT02277041 Phase 4 Carbetocin;Misoprostol
2 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Recruiting NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
3 Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial Unknown status NCT02303418 Phase 3 Carbetocin;Oxytocin
4 the Treatment of Postpartum Hemorrhage Due to Placenta Previa Complete Centralis Completed NCT02157441 Phase 2, Phase 3
5 Tranexamic Acid Use in Elective Cesarean Section for Women With Placenta Previa Completed NCT03060889 Phase 3 Tranexamic acid
6 Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor? Completed NCT01338454 Phase 3 transamin
7 Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage Completed NCT02128685 Phase 3 Dydrogesterone;Placebo
8 Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa Not yet recruiting NCT03542552 Phase 3 Magnesium Sulfate;Nifedipine
9 Cerclage for Prevention on Preterm Birth in Women With Placenta Previa Withdrawn NCT01442207 Phase 3
10 Efficacy Study of Random Placenta Margin Incision to Treat Complete Placenta Previa Completed NCT02695069 Phase 2
11 Tocolytic Therapy in Conservative Management of Symptomatic Placenta Previa Completed NCT00620724 Phase 2 Placebo;Nifedipine
12 Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa Completed NCT02688127 Phase 1, Phase 2 Tranexamic Acid
13 Intramuscular Hydroxyprogesterone Caproate and Placenta Previa Completed NCT03130504 Phase 2 17α hydroxy progesterone caproate
14 The Foley's Catheter Balloon to the Bleeding From Placenta Previa Completed NCT02640885 Phase 2
15 Progesterone in Patients With Placenta Previa Recruiting NCT03633175 Phase 2 Vaginal progesterone
16 Bakri Balloon in Placenta Previa Not yet recruiting NCT02694341 Phase 2
17 ADAMTS,Proteoglycan and Oxidant / Antioxidant Enzyme Levels of Placenta Previa Totalis (Accreta, Increta, Percreta). Unknown status NCT02270593
18 The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta Unknown status NCT02590484 Not Applicable
19 Placenta Accreta&Its Complications in Placenta Previa Cases Unknown status NCT02606474
20 Antenatal Diagnosis of Placental Attachment Disorders Unknown status NCT02442518
21 Transperineal Ultrasound to Assess the Progress of Labour Unknown status NCT02430038
22 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta Unknown status NCT02784886
23 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624 Not Applicable
24 Patient Attitudes Toward Ultrasound Measurement of Cervical Length Unknown status NCT01482039 Not Applicable
25 Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS) Unknown status NCT01431352 Not Applicable Letrozole;Chinese herbal medicine granules or Chinese herbal medicine granules placebo
26 The Placenta Previa and Fetal Weight Completed NCT03321435
27 Uterine Artery Ligation to Decrease Blood Loss With Central Placenta Previa Completed NCT02002026 Not Applicable
28 Low Implanted Second Trimester Placenta and Placenta Previa Completed NCT03431116
29 Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta Completed NCT02966197 Not Applicable
30 Non-invasive Hemoglobin Monitoring in Cesarean Section Completed NCT03409822 Not Applicable
31 Spinal Aesthesia in Women With Placenta Previa Percreta Completed NCT02686242
32 Clinical Situations at High Risk of Placenta Accreta / Percreta Completed NCT02010229
33 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01289262 Not Applicable
34 Endometriosis and Risk of Obstetric Complications Completed NCT03354793
35 TUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques Completed NCT02712099
36 Venous Air Embolism in Cesarean Delivery, Especially Placental Previa Completed NCT00985764
37 Balloon Tamponade for Atonic Primary Postpartum Hemorrhage Completed NCT02430155 Not Applicable
38 Balloon Catheters in Cases of Abnormal Placentation Completed NCT01373255 Not Applicable
39 A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings Completed NCT01990625 Not Applicable
40 Retrospective Survey of Obstetric Red Cell Transfusion in a Tertiary Women's Hospital Completed NCT03738995
41 Tranexamic Acid in Pregnancies With Vaginal Bleeding Completed NCT03632824 Not Applicable Tranexamic Acid
42 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
43 The Effect of Hysterotomy Technique on the Rate of Large Defects in the Hysterotomy Scar Completed NCT01091181 Not Applicable
44 RECAB-ASA; Treatment of Recurrent Abortion With Aspirin Completed NCT02823743 Not Applicable Aspirin;Placebo
45 Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Completed NCT01322529
46 Clinical Benefits of B-Flow Ultrasound Completed NCT02008097 Not Applicable
47 Characteristics, Complications and Perinatal Outcomes in Placenta Previa Women Recruiting NCT03774667
48 Intra-myometrial Vasopressin During Cesarean Section in Placenta Previa Recruiting NCT03725553 Not Applicable Intramyometrial Vasopressin;Placebo
49 Foley's Catheter Balloon Plus Tranexamic Acid During Cesarean Delivery for Placenta Previa Recruiting NCT03741114 Not Applicable TA;Placebo
50 Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa Recruiting NCT03570723 Not Applicable

Search NIH Clinical Center for Placenta Praevia

Cochrane evidence based reviews: placenta previa

Genetic Tests for Placenta Praevia

Anatomical Context for Placenta Praevia

MalaCards organs/tissues related to Placenta Praevia:

41
Placenta, Uterus, Cervix, Testes, Brain, Whole Blood, Lung

Publications for Placenta Praevia

Articles related to Placenta Praevia:

(show top 50) (show all 1136)
# Title Authors Year
1
Parallel vertical compression sutures to control bleeding in cases of placenta previa and accreta. ( 29034750 )
2019
2
Re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series. Spontaneous uterine rupture during the subsequent pregnancy after transverse uterine fundal incision for placenta praevia with accreta. ( 29024270 )
2018
3
Advanced maternal age and its association with placenta praevia and placental abruption: a meta-analysis. ( 29489954 )
2018
4
Women with Endometriosis, Especially Those Who Conceived with Assisted Reproductive Technology, Have Increased Risk of Placenta Previa: Meta-analyses. ( 30127709 )
2018
5
Correction to: Jenabi and Fereidooni, The uterine leiomyoma and placenta previa: a meta-analysis. ( 29690803 )
2018
6
Pregnancy with "mimicking placenta previa and large cervical leiomyoma" caused by incarcerated retroverted uterus. ( 30122592 )
2018
7
Intermittent aortic balloon occlusion combined with cesarean section for the treatment of patients with placenta previa complicated by placenta accreta: A retrospective study. ( 29974568 )
2018
8
Comment on "Discussion on the Timing of Balloon Occlusion of the Abdominal Aorta during a Caesarean Section in Patients with Pernicious Placenta Previa Complicated with Placenta Accreta". ( 30105267 )
2018
9
Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green-top Guideline No. 27a. ( 30260097 )
2018
10
Letter to 'Intermittent aortic balloon occlusion combined with cesarean section for the treatment of patients with placenta previa complicated by placenta accreta: A retrospective study': Some concerns. ( 30288864 )
2018
11
Expression of β-catenin in human trophoblast and its role in placenta accreta and placenta previa. ( 30465458 )
2018
12
Clinical and Ultrasound Predictors of Placenta Accreta in Pregnant Women with Antepartum Diagnosis of Placenta Previa: A Multicenter Study. ( 30448828 )
2018
13
A prospective evaluation and management of different types of placenta praevia using parallel vertical compression suture to preserve uterus. ( 30431609 )
2018
14
Cervical varices unrelated to placenta previa as an unusual cause of antepartum hemorrhage: A case report and literature review. ( 30342667 )
2018
15
Anesthesia management of complete versus incomplete placenta previa: a retrospective cohort study. ( 28335653 )
2018
16
Placenta previa and hemorrhage: the placental location may be an important determinant of the bleeding amount. ( 28372504 )
2018
17
Placenta Previa Increta in an Unscarred Uterus With Marked Thinning of Myometrium in the Entire Uterus in a Patient With Systemic Lupus Erythematosus. ( 28463907 )
2018
18
The role of shear wave elastography in the assessment of placenta previa-accreta. ( 28486823 )
2018
19
The association of placenta previa and assisted reproductive techniques: a meta-analysis. ( 28514884 )
2018
20
The ominous association between severe endometriosis, in vitro fertilisation, and placenta previa: raising awareness, limiting risks, informing women. ( 28618175 )
2018
21
Segmental resection of the uterine wall for placenta previa percreta: some clarifications. ( 28637369 )
2018
22
Expression of nestin in embryonic tissues and its effects on clinicopathological characteristics of patients with placenta previa. ( 28833496 )
2018
23
Sepsis after uterine artery embolization-assisted termination of pregnancy with complete placenta previa: A case report. ( 28856930 )
2018
24
Scoring model to predict massive post-partum bleeding in pregnancies with placenta previa: A retrospective cohort study. ( 29067758 )
2018
25
Retrospective multicenter study of leaving the placenta in situ for patients with placenta previa on a cesarean scar. ( 29159943 )
2018
26
Parallel vertical compression suture to the lower uterine segment for placenta previa: is conducting bladder separation first safe for abnormally invasive placenta? ( 29295658 )
2018
27
Optimal timing of antenatal corticosteroids in women with bleeding placenta previa or low-lying placenta. ( 29295659 )
2018
28
Study of the utility and problems of common iliac artery balloon occlusion for placenta previa with accreta. ( 29297951 )
2018
29
Resolution of a Low-Lying Placenta and Placenta Previa Diagnosed at the Midtrimester Anatomy Scan. ( 29399861 )
2018
30
Neuraxial Anesthesia During Cesarean Delivery for Placenta Previa With Suspected Morbidly Adherent Placenta: A Retrospective Analysis. ( 29481427 )
2018
31
Placental pathologic changes and perinatal outcomes in placenta previa. ( 29486851 )
2018
32
Diagnostic accuracy of first-trimester ultrasound in detecting abnormally invasive placenta in high-risk women with placenta previa. ( 29532529 )
2018
33
Letter to 'Scoring model to predict massive post-partum bleeding in pregnancies with placenta previa: A retrospective cohort study': The best scoring model may depend on the situation. ( 29570918 )
2018
34
Random placenta margin incision for control hemorrhage during cesarean delivery complicated by complete placenta previa: a prospective cohort study. ( 29577780 )
2018
35
A sandwich technique (N&H variation technique) to reduce blood loss during cesarean delivery for complete placenta previa: a randomized controlled trial. ( 29577789 )
2018
36
A novel scoring system for predicting adherent placenta in women with placenta previa. ( 29626978 )
2018
37
Complete Placenta Previa: Ultrasound Biometry and Surgical Outcomes. ( 29686936 )
2018
38
Correction to: Karami et al., The association of placenta previa and assisted reproductive techniques: a meta-analysis. ( 29690805 )
2018
39
A sandwich technique (N&H variation technique) to reduce blood loss during cesarean delivery for complete placenta previa; methodological and statistical concerns. ( 29690807 )
2018
40
Comparison of transabdominal and transvaginal sonography in the diagnosis of placenta previa. ( 29693718 )
2018
41
Random placenta margin incision in cesarean section for placenta previa: some clarifications. ( 29695212 )
2018
42
Nestin is highly expressed in foetal spinal cord isolated from placenta previa patients and promotes inflammation by enhancing NF-κB activity. ( 29697001 )
2018
43
Reply to: a sandwich technique (N&H variation technique) to reduce blood loss during cesarean delivery for complete placenta previa. ( 29742939 )
2018
44
The effect of advanced maternal age on maternal and neonatal outcomes of placenta previa: A register-based cohort study. ( 29859374 )
2018
45
Pre-cesarean prophylactic balloon placement in the internal iliac artery to prevent postpartum hemorrhage among women with pernicious placenta previa. ( 29876928 )
2018
46
Placenta Previa Accreta and Previous Cesarean Section: Some Clarifications. ( 29893372 )
2018
47
Reply to "Placenta Previa Accreta and Previous Cesarean Section: Some Clarifications". ( 29893373 )
2018
48
Intrauterine Inflated Foley's Catheter Balloon in the Management of Abnormally Invasive Placenta Previa: A Case-Control Study. ( 29895997 )
2018
49
Partial Molar Pregnancy with a Normal Fetus with Complete Placenta Previa. ( 29896004 )
2018
50
Feasibility of Infrarenal Abdominal Aorta Balloon Occlusion in Pernicious Placenta Previa Coexisting with Placenta Accrete. ( 29977912 )
2018

Variations for Placenta Praevia

Expression for Placenta Praevia

Search GEO for disease gene expression data for Placenta Praevia.

Pathways for Placenta Praevia

GO Terms for Placenta Praevia

Cellular components related to Placenta Praevia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 8.8 HADHA HCCS NDUFA12

Biological processes related to Placenta Praevia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 8.8 HADHA HCCS NDUFA12

Molecular functions related to Placenta Praevia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 HADHA HCCS

Sources for Placenta Praevia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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