MCID: PLC009
MIFTS: 33

Placenta Praevia

Categories: Fetal diseases

Aliases & Classifications for Placenta Praevia

MalaCards integrated aliases for Placenta Praevia:

Name: Placenta Praevia 12 15
Placenta Previa 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11060
ICD10 33 O44 O44.1
MeSH 44 D010923
NCIt 50 C26858
UMLS 73 C0032046

Summaries for Placenta Praevia

Disease Ontology : 12 A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.

MalaCards based summary : Placenta Praevia, also known as placenta previa, is related to placenta disease and low implantation of placenta. An important gene associated with Placenta Praevia is NDUFA12 (NADH:Ubiquinone Oxidoreductase Subunit A12). The drugs Tranexamic Acid and Alprostadil have been mentioned in the context of this disorder. Affiliated tissues include placenta, cervix and uterus, and related phenotype is growth/size/body region.

Wikipedia : 76 Placenta praevia is when the placenta attaches inside the uterus but near or over the cervical opening.... more...

Related Diseases for Placenta Praevia

Diseases related to Placenta Praevia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 placenta disease 28.7 EPHA1 HADHA SERPINH1
2 low implantation of placenta 10.4
3 vaginitis 10.3
4 placenta accreta 10.3
5 placental abruption 10.2
6 aging 10.2
7 cervicitis 10.2
8 hydatidiform mole, recurrent, 1 9.9
9 sarcoma 9.9
10 thymoma 9.9
11 gestational trophoblastic neoplasm 9.9
12 malignant hyperthermia 9.9
13 malignant hyperthermia susceptibility 9.9
14 uterine sarcoma 9.9
15 uterine anomalies 9.4 EPHA1 SERPINH1

Graphical network of the top 20 diseases related to Placenta Praevia:



Diseases related to Placenta Praevia

Symptoms & Phenotypes for Placenta Praevia

MGI Mouse Phenotypes related to Placenta Praevia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.02 AATF EPHA1 FOXK1 HADHA SERPINH1

Drugs & Therapeutics for Placenta Praevia

Drugs for Placenta Praevia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1,Phase 2 1197-18-8 5526
2
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
3
Carbetocin Approved, Investigational Phase 4,Phase 3 37025-55-1 71715 16681432
4
Misoprostol Approved Phase 4 59122-46-2 5282381
5
Oxytocin Approved, Vet_approved Phase 4,Phase 3 50-56-6 439302 53477758
6 Antifibrinolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
7 Coagulants Phase 4,Phase 3,Phase 1,Phase 2
8 Hemostatics Phase 4,Phase 3,Phase 1,Phase 2
9 Antacids Phase 4
10 Anti-Ulcer Agents Phase 4
11 Gastrointestinal Agents Phase 4
12 Oxytocics Phase 4,Phase 3
13 Hormone Antagonists Phase 3,Phase 2,Not Applicable
14 Hormones Phase 3,Phase 2,Not Applicable
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
16 Anesthetics Phase 3
17 Progestins Phase 3,Phase 2,Not Applicable
18 Analgesics Phase 3,Not Applicable
19 calcium channel blockers Phase 3,Phase 2
20 Calcium, Dietary Phase 3,Phase 2
21 Central Nervous System Depressants Phase 3
22 Peripheral Nervous System Agents Phase 3,Not Applicable
23 Tocolytic Agents Phase 3,Phase 2
24
Nifedipine Approved Phase 2 21829-25-4 4485
25
Progesterone Approved, Vet_approved Phase 2,Not Applicable 57-83-0 5994
26 Estrogen Antagonists Phase 2,Not Applicable
27 Estrogens Phase 2,Not Applicable
28 Vasodilator Agents Phase 2
29 11-hydroxyprogesterone Phase 2,Not Applicable
30 17-alpha-hydroxy-progesterone caproate Phase 2,Not Applicable
31 Caproate Nutraceutical Phase 2,Not Applicable
32
Menthol Approved Not Applicable 2216-51-5 16666
33
Letrozole Approved, Investigational Not Applicable 112809-51-5 3902
34
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
35
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
36
Menotropins Approved Not Applicable 61489-71-2, 9002-68-0 5360545
37
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
38 Deslorelin Investigational, Vet_approved Not Applicable 57773-65-6
39 Antioxidants
40 Protective Agents
41 Aromatase Inhibitors Not Applicable
42 Steroid Synthesis Inhibitors Not Applicable
43 Analgesics, Non-Narcotic Not Applicable
44 Anti-Inflammatory Agents Not Applicable
45 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
46 Antipyretics Not Applicable
47 Antirheumatic Agents Not Applicable
48 Cyclooxygenase Inhibitors Not Applicable
49 Fibrinolytic Agents Not Applicable
50 Platelet Aggregation Inhibitors Not Applicable

Interventional clinical trials:

(show top 50) (show all 73)
# Name Status NCT ID Phase Drugs
1 Carbetocin Versus Misoprostol in Cases With Placenta Previa After C.S. Recruiting NCT02277041 Phase 4 Carbetocin;Misoprostol
2 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Recruiting NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
3 the Treatment of Postpartum Hemorrhage Due to Placenta Previa Complete Centralis Completed NCT02157441 Phase 2, Phase 3
4 Tranexamic Acid Use in Elective Cesarean Section for Women With Placenta Previa Completed NCT03060889 Phase 3 Tranexamic acid
5 Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor? Completed NCT01338454 Phase 3 transamin
6 Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial Recruiting NCT02303418 Phase 3 Carbetocin;Oxytocin
7 Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage Recruiting NCT02128685 Phase 3 Dydrogesterone;Placebo
8 Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa Not yet recruiting NCT03542552 Phase 3 Magnesium Sulfate;Nifedipine
9 Cerclage for Prevention on Preterm Birth in Women With Placenta Previa Withdrawn NCT01442207 Phase 3
10 Efficacy Study of Random Placenta Margin Incision to Treat Complete Placenta Previa Completed NCT02695069 Phase 2
11 Tocolytic Therapy in Conservative Management of Symptomatic Placenta Previa Completed NCT00620724 Phase 2 Placebo;Nifedipine
12 Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa Completed NCT02688127 Phase 1, Phase 2 Tranexamic Acid
13 Intramuscular Hydroxyprogesterone Caproate and Placenta Previa Completed NCT03130504 Phase 2 17α hydroxy progesterone caproate
14 The Foley's Catheter Balloon to the Bleeding From Placenta Previa Completed NCT02640885 Phase 2
15 Bakri Balloon in Placenta Previa Not yet recruiting NCT02694341 Phase 2
16 ADAMTS,Proteoglycan and Oxidant / Antioxidant Enzyme Levels of Placenta Previa Totalis (Accreta, Increta, Percreta). Unknown status NCT02270593
17 The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta Unknown status NCT02590484 Not Applicable
18 Placenta Accreta&Its Complications in Placenta Previa Cases Unknown status NCT02606474
19 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta Unknown status NCT02784886
20 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624 Not Applicable
21 Patient Attitudes Toward Ultrasound Measurement of Cervical Length Unknown status NCT01482039 Not Applicable
22 Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS) Unknown status NCT01431352 Not Applicable Letrozole;Chinese herbal medicine granules or Chinese herbal medicine granules placebo
23 The Placenta Previa and Fetal Weight Completed NCT03321435
24 Uterine Artery Ligation to Decrease Blood Loss With Central Placenta Previa Completed NCT02002026 Not Applicable
25 Low Implanted Second Trimester Placenta and Placenta Previa Completed NCT03431116
26 Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta Completed NCT02966197 Not Applicable
27 Spinal Aesthesia in Women With Placenta Previa Percreta Completed NCT02686242
28 Clinical Situations at High Risk of Placenta Accreta / Percreta Completed NCT02010229
29 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01289262 Not Applicable
30 Endometriosis and Risk of Obstetric Complications Completed NCT03354793
31 TUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques Completed NCT02712099
32 Venous Air Embolism in Cesarean Delivery, Especially Placental Previa Completed NCT00985764
33 Balloon Tamponade for Atonic Primary Postpartum Hemorrhage Completed NCT02430155 Not Applicable
34 Balloon Catheters in Cases of Abnormal Placentation Completed NCT01373255 Not Applicable
35 A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings Completed NCT01990625 Not Applicable
36 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
37 The Effect of Hysterotomy Technique on the Rate of Large Defects in the Hysterotomy Scar Completed NCT01091181 Not Applicable
38 RECAB-ASA; Treatment of Recurrent Abortion With Aspirin Completed NCT02823743 Not Applicable Aspirin;Placebo
39 Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Completed NCT01322529
40 Clinical Benefits of B-Flow Ultrasound Completed NCT02008097 Not Applicable
41 Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa Recruiting NCT03570723 Not Applicable
42 Non-invasive Hemoglobin Monitoring in Cesarean Section Recruiting NCT03409822 Not Applicable
43 Antenatal Diagnosis of Placental Attachment Disorders Recruiting NCT02442518
44 Effect of Uterine Artery Ligation Prior to Uterine Incision in Women With Placenta Previa Recruiting NCT03124472 Not Applicable
45 Role of Ultrasound in Diagnosis of Placenta Previa and MAP Recruiting NCT03416296
46 Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa Recruiting NCT03266432 Not Applicable
47 Comparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar Recruiting NCT03437291
48 Uterine Cavity and Blood Flow After Conservative Management of Placenta Previa/Accreta Recruiting NCT02878187
49 Transperineal Ultrasound to Assess the Progress of Labour Recruiting NCT02430038
50 Creatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Abnormal Adherent Placenta. Recruiting NCT03224780

Search NIH Clinical Center for Placenta Praevia

Cochrane evidence based reviews: placenta previa

Genetic Tests for Placenta Praevia

Anatomical Context for Placenta Praevia

MalaCards organs/tissues related to Placenta Praevia:

41
Placenta, Cervix, Uterus, Ovary, Liver

Publications for Placenta Praevia

Articles related to Placenta Praevia:

(show top 50) (show all 347)
# Title Authors Year
1
Re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series. Spontaneous uterine rupture during the subsequent pregnancy after transverse uterine fundal incision for placenta praevia with accreta. ( 29024270 )
2018
2
Advanced maternal age and its association with placenta praevia and placental abruption: a meta-analysis. ( 29489954 )
2018
3
Placenta praevia and the risk of adverse outcomes during second trimester abortion: A retrospective cohort study. ( 28251636 )
2017
4
Multifaceted spiral suture: A hemostatic technique in managing placenta praevia or accrete: A retrospective study. ( 29245338 )
2017
5
Surgical management of 58 patients with placenta praevia percreta. ( 26913862 )
2016
6
CT diagnosis of spontaneous uterine rupture at term, sonographic appearance of which was confused with placenta praevia. ( 27920419 )
2016
7
Author's reply re: Caesarean hysterectomy for placenta praevia/accreta using an approach via the pouch of Douglas. ( 27531340 )
2016
8
Re: Caesarean hysterectomy for placenta praevia/accreta using an approach via the pouch of Douglas: Is retrograde hysterectomy a new technique? ( 27531339 )
2016
9
Re: Caesarean hysterectomy for placenta praevia/accreta using an approach via the pouch of Douglas. ( 27272303 )
2016
10
Outcome of Pregnancies After Balloon Occlusion of the Infrarenal Abdominal Aorta During Caesarean in 230 Patients With Placenta Praevia Accreta. ( 27439624 )
2016
11
Exposure to air pollutants during the early weeks of pregnancy, and placenta praevia and placenta accreta in the western part of Japan. ( 27164555 )
2016
12
Author's reply re: Caesarean hysterectomy for placenta praevia/accreta using an approach via the pouch of Douglas. ( 27272305 )
2016
13
Caesarean hysterectomy for placenta praevia/accreta using an approach via the pouch of Douglas. ( 26642997 )
2016
14
Placenta praevia: incidence, risk factors and outcome. ( 26043298 )
2015
15
Authors' reply re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series. ( 26589856 )
2015
16
Transverse uterine fundal incision for placenta praevia with accreta: concern regarding its 'overuse'. ( 25623586 )
2015
17
Re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series: How to reduce overuse of the new method for dealing with placenta praevia suggested by Kotsuji et al. ( 26589855 )
2015
18
A score to predict the risk of emergency caesarean delivery in women with antepartum bleeding and placenta praevia. ( 26550944 )
2015
19
Risk of placenta praevia is linked to endometrial thickness in a retrospective cohort study of 4537 singleton assisted reproduction technology birthsa8 . ( 25240011 )
2014
20
Maternal and perinatal outcomes in women with placenta praevia and accreta in teaching hospitals in Western Turkey. ( 24734898 )
2014
21
Singleton pregnancy outcomes after in vitro fertilization with fresh or frozen-thawed embryo transfer and incidence of placenta praevia. ( 24822209 )
2014
22
Factors associated with placenta praevia in primigravidas and its pregnancy outcome. ( 25478587 )
2014
23
An audit to review the characteristics and management of placenta praevia at Aberdeen Maternity Hospital, 2009-2011. ( 24702527 )
2014
24
A novel 'uterine sandwich' for haemorrhage at caesarean section for placenta praevia. ( 24506478 )
2014
25
Authors' reply: placenta praevia accreta. ( 24738904 )
2014
26
Placenta praevia accreta. ( 24738903 )
2014
27
Transverse uterine fundal incision for anterior placenta praevia accreta: more harm than good? ( 24738901 )
2014
28
Authors' reply: transverse uterine fundal incision for placenta praevia with accreta. ( 24738900 )
2014
29
Authors' reply: transverse uterine fundal incision in placenta praevia with possible placenta accreta. ( 24738902 )
2014
30
Transverse uterine fundal incision for placenta praevia with accreta. ( 24738899 )
2014
31
A clinical analysis of uterine artery embolisation in the treatment of placenta praevia or placenta praevia state. ( 24911560 )
2014
32
Placenta praevia, placental abruption and amphetamine use in pregnancy: a case study. ( 23266230 )
2013
33
Novel MRI finding for diagnosis of invasive placenta praevia: evaluation of findings for 65 patients using clinical and histopathological correlations. ( 24272229 )
2013
34
Cervical varicosities and placenta praevia. ( 23919618 )
2013
35
Caesarean hysterectomy for placenta praevia accreta: filling the bladder technique to identify an appropriate bladder separation site. ( 23445140 )
2013
36
Placenta praevia after prior caesarean section: an exploratory case-control study. ( 23738611 )
2013
37
Prevalence of placenta praevia by world region: a systematic review and meta-analysis. ( 23551357 )
2013
38
Per operative discovery of placenta praevia percreta: a case report. ( 24672624 )
2013
39
Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series. ( 23639121 )
2013
40
Caesarean section in cases of placenta praevia and accreta. ( 23127895 )
2013
41
Metastatic thymoma, placenta praevia and two successful pregnancies: an obstetric challenge. ( 23078948 )
2013
42
Increased incidence of placenta praevia and accreta with previous caesareans--a hypothesis for causation. ( 24219718 )
2013
43
Double vertical compression sutures: A novel conservative approach to managing post-partum haemorrhage due to placenta praevia and atonic bleeding. ( 22413844 )
2012
44
Trends and recurrence of placenta praevia: a population-based study. ( 22862285 )
2012
45
Placenta praevia increta with caesarean section scar invasion. ( 21853940 )
2011
46
Management of placenta praevia and accreta. ( 21280984 )
2011
47
Maternal morbidity associated with placenta praevia among women who had elective caesarean section. ( 21835537 )
2011
48
Post-partum haemorrhage from the lower uterine segment secondary to placenta praevia/accreta: successful conservative management with Foley balloon tamponade. ( 21806571 )
2011
49
No bleeding before, more bleeding later: the relationship between the presence of warning bleeding and the amount of bleeding during caesarean section in placenta praevia. ( 21126125 )
2010
50
Is it possible to reduce rates of placenta praevia? ( 20578609 )
2010

Variations for Placenta Praevia

Expression for Placenta Praevia

Search GEO for disease gene expression data for Placenta Praevia.

Pathways for Placenta Praevia

GO Terms for Placenta Praevia

Sources for Placenta Praevia

3 CDC
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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