MCID: PLC009
MIFTS: 39

Placenta Praevia

Categories: Fetal diseases

Aliases & Classifications for Placenta Praevia

Summaries for Placenta Praevia

Disease Ontology : 12 A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.

MalaCards based summary : Placenta Praevia, also known as placenta previa, is related to placental abruption and placenta accreta. An important gene associated with Placenta Praevia is NDUFA12 (NADH:Ubiquinone Oxidoreductase Subunit A12), and among its related pathways/superpathways are GABAergic synapse and Tyrosine Kinases / Adaptors. The drugs Oxytocin and Carbetocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and cervix.

Wikipedia : 77 Placenta praevia is when the placenta attaches inside the uterus but near or over the cervical opening.... more...

Related Diseases for Placenta Praevia

Diseases related to Placenta Praevia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 placental abruption 10.6
2 placenta accreta 10.5
3 endometriosis 10.3
4 pre-eclampsia 10.3
5 leiomyoma 10.3
6 eclampsia 10.3
7 leiomyoma, uterine 10.2
8 severe pre-eclampsia 10.2
9 afibrinogenemia 10.2
10 hydatidiform mole, recurrent, 1 10.1
11 thymoma, familial 10.1
12 sarcoma 10.1
13 thymoma 10.1
14 gestational trophoblastic neoplasm 10.1
15 malignant hyperthermia 10.1
16 uterine sarcoma 10.1
17 systemic lupus erythematosus 10.0
18 marfan syndrome 10.0
19 varicose veins 10.0
20 respiratory distress syndrome in premature infants 10.0
21 lung cancer susceptibility 3 10.0
22 lymphatic malformation 7 10.0
23 cerebral palsy 10.0
24 diabetes mellitus 10.0
25 hepatitis 10.0
26 hepatitis b 10.0
27 newborn respiratory distress syndrome 10.0
28 ectopic pregnancy 10.0
29 thrombosis 10.0
30 neonatal anemia 10.0
31 von willebrand's disease 10.0
32 periventricular leukomalacia 10.0
33 adenocarcinoma 10.0
34 placental site trophoblastic tumor 10.0
35 pyoderma 10.0
36 infertility 10.0
37 placenta disease 10.0
38 pyoderma gangrenosum 10.0
39 lupus erythematosus 10.0
40 pulmonary embolism 10.0
41 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.0
42 factor v deficiency 10.0
43 blue rubber bleb nevus 10.0
44 asherman's syndrome 10.0
45 fetal edema 10.0
46 hydrops fetalis 10.0
47 leukomalacia 10.0
48 respiratory distress syndrome, infant 10.0

Graphical network of the top 20 diseases related to Placenta Praevia:



Diseases related to Placenta Praevia

Symptoms & Phenotypes for Placenta Praevia

Drugs & Therapeutics for Placenta Praevia

Drugs for Placenta Praevia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 4,Phase 3 50-56-6 53477758 439302
2
Carbetocin Approved, Investigational Phase 4,Phase 3 37025-55-1 16681432 71715
3
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1197-18-8 5526
4
Alprostadil Approved, Investigational Phase 4 745-65-3 5280723 149351
5
Misoprostol Approved Phase 4 59122-46-2 5282381
6 Oxytocics Phase 4,Phase 3
7 Antifibrinolytic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
8 Hemostatics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Coagulants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Antacids Phase 4
11 Anti-Ulcer Agents Phase 4
12 Gastrointestinal Agents Phase 4
13
Nifedipine Approved Phase 3,Phase 2 21829-25-4 4485
14
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
15
Calcium Approved, Nutraceutical Phase 3,Phase 2 7440-70-2 271
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
17 Hormones Phase 3,Phase 2,Not Applicable
18 Hormone Antagonists Phase 3,Phase 2,Not Applicable
19 Anesthetics Phase 3
20 Progestins Phase 3,Phase 2,Not Applicable
21 Peripheral Nervous System Agents Phase 3,Not Applicable
22 Central Nervous System Depressants Phase 3
23 Calcium, Dietary Phase 3,Phase 2
24 Analgesics Phase 3,Not Applicable
25 Vasodilator Agents Phase 3,Phase 2
26 Tocolytic Agents Phase 3,Phase 2
27 calcium channel blockers Phase 3,Phase 2
28 Anticonvulsants Phase 3
29 Anti-Arrhythmia Agents Phase 3
30
Progesterone Approved, Vet_approved Phase 2,Not Applicable 57-83-0 5994
31
Emodepside Investigational, Vet_approved Phase 1, Phase 2 155030-63-0
32 Estrogens Phase 2,Not Applicable
33 Estrogen Receptor Antagonists Phase 2,Not Applicable
34 Estrogen Antagonists Phase 2,Not Applicable
35 11-hydroxyprogesterone Phase 2,Not Applicable
36 Caproate Phase 2,Not Applicable
37 17 alpha-Hydroxyprogesterone Caproate Phase 2,Not Applicable
38
Letrozole Approved, Investigational Not Applicable 112809-51-5 3902
39
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
40
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
41
Menotropins Approved Not Applicable 9002-68-0, 61489-71-2 5360545
42
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
43 Deslorelin Investigational, Vet_approved Not Applicable 57773-65-6
44 Antioxidants
45 Protective Agents
46 Steroid Synthesis Inhibitors Not Applicable
47 Aromatase Inhibitors Not Applicable
48 Antipyretics Not Applicable
49 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
50 Analgesics, Non-Narcotic Not Applicable

Interventional clinical trials:

(show top 50) (show all 88)
# Name Status NCT ID Phase Drugs
1 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Completed NCT02806024 Phase 4 Tranexamic Acid;Placebo Drug
2 Carbetocin Versus Misoprostol in Cases With Placenta Previa After C.S. Recruiting NCT02277041 Phase 4 Carbetocin;Misoprostol
3 Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial Unknown status NCT02303418 Phase 3 Carbetocin;Oxytocin
4 the Treatment of Postpartum Hemorrhage Due to Placenta Previa Complete Centralis Completed NCT02157441 Phase 2, Phase 3
5 Tranexamic Acid Use in Elective Cesarean Section for Women With Placenta Previa Completed NCT03060889 Phase 3 Tranexamic acid
6 Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor? Completed NCT01338454 Phase 3 transamin
7 Internal Iliac Artery Ligation Before Cesarean Hysterectomy in Morbidly Adherent Placenta Completed NCT03824873 Phase 3
8 Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage Completed NCT02128685 Phase 3 Dydrogesterone;Placebo
9 Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa Not yet recruiting NCT03542552 Phase 3 Magnesium Sulfate;Nifedipine
10 Cerclage for Prevention on Preterm Birth in Women With Placenta Previa Withdrawn NCT01442207 Phase 3
11 Efficacy Study of Random Placenta Margin Incision to Treat Complete Placenta Previa Completed NCT02695069 Phase 2
12 Tocolytic Therapy in Conservative Management of Symptomatic Placenta Previa Completed NCT00620724 Phase 2 Placebo;Nifedipine
13 Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa Completed NCT02688127 Phase 1, Phase 2 Tranexamic Acid
14 Intramuscular Hydroxyprogesterone Caproate and Placenta Previa Completed NCT03130504 Phase 2 17α hydroxy progesterone caproate
15 The Foley's Catheter Balloon to the Bleeding From Placenta Previa Completed NCT02640885 Phase 2
16 Progesterone in Patients With Placenta Previa Recruiting NCT03633175 Phase 2 Vaginal progesterone
17 Bakri Balloon in Placenta Previa Not yet recruiting NCT02694341 Phase 2
18 ADAMTS,Proteoglycan and Oxidant / Antioxidant Enzyme Levels of Placenta Previa Totalis (Accreta, Increta, Percreta). Unknown status NCT02270593
19 The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta Unknown status NCT02590484 Not Applicable
20 Placenta Accreta&Its Complications in Placenta Previa Cases Unknown status NCT02606474
21 Antenatal Diagnosis of Placental Attachment Disorders Unknown status NCT02442518
22 Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta Unknown status NCT02784886
23 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624 Not Applicable
24 Patient Attitudes Toward Ultrasound Measurement of Cervical Length Unknown status NCT01482039 Not Applicable
25 Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS) Unknown status NCT01431352 Not Applicable Letrozole;Chinese herbal medicine granules or Chinese herbal medicine granules placebo
26 The Placenta Previa and Fetal Weight Completed NCT03321435
27 Uterine Artery Ligation to Decrease Blood Loss With Central Placenta Previa Completed NCT02002026 Not Applicable
28 Low Implanted Second Trimester Placenta and Placenta Previa Completed NCT03431116
29 Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta Completed NCT02966197 Not Applicable
30 Non-invasive Hemoglobin Monitoring in Cesarean Section Completed NCT03409822 Not Applicable
31 Spinal Aesthesia in Women With Placenta Previa Percreta Completed NCT02686242
32 Clinical Situations at High Risk of Placenta Accreta / Percreta Completed NCT02010229
33 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01289262 Not Applicable
34 Transperineal Ultrasound to Assess the Progress of Labour Completed NCT02430038
35 Endometriosis and Risk of Obstetric Complications Completed NCT03354793
36 TUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques Completed NCT02712099
37 Venous Air Embolism in Cesarean Delivery, Especially Placental Previa Completed NCT00985764
38 Balloon Tamponade for Atonic Primary Postpartum Hemorrhage Completed NCT02430155 Not Applicable
39 Balloon Catheters in Cases of Abnormal Placentation Completed NCT01373255 Not Applicable
40 A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings Completed NCT01990625 Not Applicable
41 Sim (Scratch in Miscarriage) Study Completed NCT02681627 Not Applicable
42 Retrospective Survey of Obstetric Red Cell Transfusion in a Tertiary Women's Hospital Completed NCT03738995
43 Tranexamic Acid in Pregnancies With Vaginal Bleeding Completed NCT03632824 Not Applicable Tranexamic Acid
44 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
45 The Effect of Hysterotomy Technique on the Rate of Large Defects in the Hysterotomy Scar Completed NCT01091181 Not Applicable
46 RECAB-ASA; Treatment of Recurrent Abortion With Aspirin Completed NCT02823743 Not Applicable Aspirin;Placebo
47 Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Completed NCT01322529
48 Clinical Benefits of B-Flow Ultrasound Completed NCT02008097 Not Applicable
49 Characteristics, Complications and Perinatal Outcomes in Placenta Previa Women Recruiting NCT03774667
50 Intra-myometrial Vasopressin During Cesarean Section in Placenta Previa Recruiting NCT03725553 Not Applicable Intramyometrial Vasopressin;Placebo

Search NIH Clinical Center for Placenta Praevia

Cochrane evidence based reviews: placenta previa

Genetic Tests for Placenta Praevia

Anatomical Context for Placenta Praevia

MalaCards organs/tissues related to Placenta Praevia:

42
Placenta, Uterus, Cervix, Ovary, Testes, Endothelial, Eye

Publications for Placenta Praevia

Articles related to Placenta Praevia:

(show top 50) (show all 1223)
# Title Authors Year
1
Parallel vertical compression sutures to control bleeding in cases of placenta previa and accreta. ( 29034750 )
2019
2
Placenta previa without morbidly adherent placenta: comparison of characteristics and outcomes between planned and emergent deliveries in a tertiary center. ( 29046070 )
2019
3
Parallel vertical compression suture to the lower uterine segment for placenta previa: is conducting bladder separation first safe for abnormally invasive placenta? ( 29295658 )
2019
4
Bleeding control using intrauterine continuous running suture during cesarean section in pregnant women with placenta previa. ( 30386992 )
2019
5
Bilateral uterine artery ligation plus intravenous tranexamic acid during cesarean delivery for placenta previa: a randomized double-blind controlled trial. ( 30412786 )
2019
6
Comparison of Efficacy between Internal Iliac Artery and Abdominal Aorta Balloon Occlusions in Pernicious Placenta Previa Patients with Placenta Accrete. ( 30625467 )
2019
7
Internal iliac artery balloon occlusion during cesarean hysterectomy in women with placenta previa accreta. ( 30667043 )
2019
8
Prophylactic abdominal aortic balloon occlusion: An effective method of controlling hemorrhage in patients with placenta previa or accreta. ( 30680033 )
2019
9
Corrigendum to "Placental pathologic changes and perinatal outcomes in placenta previa" [Placenta 63 C (2018) 15-20]. ( 30772007 )
2019
10
Conservative endovascular and hysteroscopic management of a cesarean scar pregnancy in a woman with previous history of uterine artery embolization for intractable hemorrhage after cesarean section for placenta previa. ( 30899486 )
2019
11
Parallel transverse uterine incisions combined with cell salvage minimized bleeding in a patient with pernicious placenta previa and an unexplained decrease in hemoglobin after transfusion of allogeneic red blood cells: A case report. ( 31045807 )
2019
12
Undiagnosed placenta praevia percreta: A rare case report and review of management. ( 30860201 )
2019
13
Associated factors of blood transfusion for Caesarean sections in pure placenta praevia pregnancies. ( 30854569 )
2019
14
Machine learning analysis of MRI-derived texture features to predict placenta accreta spectrum in patients with placenta previa. ( 31102613 )
2019
15
The effectiveness of prophylactic internal iliac artery balloon occlusion in the treatment of patients with pernicious placenta previa coexisting with placenta accreta. ( 30961402 )
2019
16
Successful resuscitation of a patient with pernicious placenta previa and placenta accreta who had massive life-threatening bleeding during cesarean section: A case report. ( 30946336 )
2019
17
Expression of Cripto-1 in the placenta and its role in placenta accreta and placenta previa. ( 30860275 )
2019
18
Impact of placenta previa with placenta accreta spectrum disorder on fetal growth. ( 30779235 )
2019
19
Prenatal planning of placenta previa: diagnostic accuracy of a novel MRI-based prediction model for placenta accreta spectrum (PAS) and clinical outcome. ( 30600374 )
2019
20
Expression of β-catenin in human trophoblast and its role in placenta accreta and placenta previa. ( 30465458 )
2019
21
Letter to 'Intermittent aortic balloon occlusion combined with cesarean section for the treatment of patients with placenta previa complicated by placenta accreta: A retrospective study': Some concerns. ( 30288864 )
2019
22
Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green-top Guideline No. 27a. ( 30260097 )
2019
23
The Jellyfish Sign: A New Sonographic Cervical Marker to Predict Maternal Morbidity in Abnormally Invasive Placenta Previa. ( 29161751 )
2019
24
Optimal timing of antenatal corticosteroids in women with bleeding placenta previa or low-lying placenta. ( 29295659 )
2019
25
The role of cervical pessary and progesterone therapy in the phenomenon of placenta previa migration. ( 30081730 )
2019
26
Prophylactic uterine artery embolization in second-trimester pregnancy termination with complete placenta previa. ( 30318981 )
2019
27
Analysis of prophylactic Bakri balloon tamponade failure in patients with placenta previa. ( 30638472 )
2019
28
Effect of the delivery way and number of parity in the subsequent incidence of placenta previa. ( 30669901 )
2019
29
Clinical analysis of uterine artery embolization combined with double balloon catheter plus curettage for patients with placenta previa who underwent pregnancy termination and suffered antenatal massive hemorrhage in the 2nd trimester: Three case reports. ( 30681626 )
2019
30
Diagnosis and management of placenta previa and low placental implantation. ( 30688129 )
2019
31
A new surgical technique "cervical internal os plasty" in cesarean delivery for placenta previa accreta: A case-control study. ( 30817563 )
2019
32
Cervical Pessary versus Expectant Management for the Prevention of Delivery Prior to 36 Weeks in Women with Placenta Previa: A Randomized Controlled Trial. ( 31044098 )
2019
33
Prognosis and related risk factors of patients with scarred uterus complicated with central placenta previa. ( 31059110 )
2019
34
Women with Endometriosis, Especially Those Who Conceived with Assisted Reproductive Technology, Have Increased Risk of Placenta Previa: Meta-analyses. ( 30127709 )
2018
35
Expression of nestin in embryonic tissues and its effects on clinicopathological characteristics of patients with placenta previa. ( 28833496 )
2018
36
Sepsis after uterine artery embolization-assisted termination of pregnancy with complete placenta previa: A case report. ( 28856930 )
2018
37
Cervical varices unrelated to placenta previa as an unusual cause of antepartum hemorrhage: A case report and literature review. ( 30342667 )
2018
38
Resolution of a Low-Lying Placenta and Placenta Previa Diagnosed at the Midtrimester Anatomy Scan. ( 29399861 )
2018
39
Neuraxial Anesthesia During Cesarean Delivery for Placenta Previa With Suspected Morbidly Adherent Placenta: A Retrospective Analysis. ( 29481427 )
2018
40
Letter to 'Scoring model to predict massive post-partum bleeding in pregnancies with placenta previa: A retrospective cohort study': The best scoring model may depend on the situation. ( 29570918 )
2018
41
A sandwich technique (N&H variation technique) to reduce blood loss during cesarean delivery for complete placenta previa: a randomized controlled trial. ( 29577789 )
2018
42
Complete Placenta Previa: Ultrasound Biometry and Surgical Outcomes. ( 29686936 )
2018
43
Correction to: Karami et al., The association of placenta previa and assisted reproductive techniques: a meta-analysis. ( 29690805 )
2018
44
A sandwich technique (N&H variation technique) to reduce blood loss during cesarean delivery for complete placenta previa; methodological and statistical concerns. ( 29690807 )
2018
45
Random placenta margin incision in cesarean section for placenta previa: some clarifications. ( 29695212 )
2018
46
Nestin is highly expressed in foetal spinal cord isolated from placenta previa patients and promotes inflammation by enhancing NF-κB activity. ( 29697001 )
2018
47
Reply to: a sandwich technique (N&H variation technique) to reduce blood loss during cesarean delivery for complete placenta previa. ( 29742939 )
2018
48
External iliac artery thrombosis after hypogastric artery ligation and pelvic packing for placenta previa percreta. ( 29971191 )
2018
49
Placenta Previa Accreta and Previous Cesarean Section: Some Clarifications. ( 29893372 )
2018
50
Reply to "Placenta Previa Accreta and Previous Cesarean Section: Some Clarifications". ( 29893373 )
2018

Variations for Placenta Praevia

Expression for Placenta Praevia

Search GEO for disease gene expression data for Placenta Praevia.

Pathways for Placenta Praevia

Pathways related to Placenta Praevia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.32 ARRB2 GLS2 NDUFA12
2 11.13 ARRB2 EPHA1
3 10.7 ARRB2 EPHA1

GO Terms for Placenta Praevia

Biological processes related to Placenta Praevia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of signal transduction GO:0009968 8.32 ARRB2

Molecular functions related to Placenta Praevia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.32 ADGRL3

Sources for Placenta Praevia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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