MCID: PLC007
MIFTS: 50

Placental Abruption

Categories: Fetal diseases

Aliases & Classifications for Placental Abruption

MalaCards integrated aliases for Placental Abruption:

Name: Placental Abruption 12 76 15
Abruptio Placentae 12 55 73
Abortion, Threatened 44
Abruptio Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9667
ICD10 33 O20.0
ICD9CM 35 640.0 640.03
MeSH 44 D000033
NCIt 50 C112857

Summaries for Placental Abruption

Disease Ontology : 12 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards based summary : Placental Abruption, also known as abruptio placentae, is related to placenta disease and placenta accreta. An important gene associated with Placental Abruption is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Methyldopa and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Placental abruption is when the placenta separates early from the uterus, in other words separates... more...

Related Diseases for Placental Abruption

Diseases related to Placental Abruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 placenta disease 31.4 APOH F5 MTHFR PGF SERPINC1
2 placenta accreta 30.1 FLT1 PGF
3 disseminated intravascular coagulation 29.8 F2 F5 SERPINC1 THBD
4 severe pre-eclampsia 29.4 APOH F5 PGF SERPINC1
5 dysfibrinogenemia 29.3 F2 F5 SERPINC1 THBD
6 thrombophilia 28.7 APOH F2 F5 MTHFR SERPINC1 THBD
7 thrombosis 28.2 APOH F2 F5 MTHFR SERPINC1 THBD
8 eclampsia 26.9 ENG F2 F5 FLT1 MTHFR PGF
9 hellp syndrome 25.6 APOH ENG F2 F5 FLT1 MTHFR
10 pre-eclampsia 25.6 AGT APOH ENG F2 F5 FLT1
11 kidney cortex necrosis 11.2
12 inferior vena cava interruption 10.8 F5 MTHFR
13 paracetamol poisoning 10.8 F2 F5
14 amaurosis fugax 10.8 F5 MTHFR
15 may-thurner syndrome 10.8 APOH F5
16 mesenteric vascular occlusion 10.7 F2 MTHFR
17 acanthamoeba keratitis 10.7 APOH F5
18 hemoglobin e disease 10.7 F2 F5
19 pregnancy loss, recurrent 1 10.7 APOH F5
20 ischemic neuropathy 10.7 F2 MTHFR
21 factor viii deficiency 10.7 F2 F5
22 splenic infarction 10.6 APOH F2
23 papilledema 10.6 APOH F2
24 cryptogenic cirrhosis 10.5 F2 F5 MTHFR
25 porencephaly 10.5 F2 F5 MTHFR
26 arteritic anterior ischemic optic neuropathy 10.5 F2 F5 MTHFR
27 thrombasthenia 10.5 F2 F5 MTHFR
28 sticky platelet syndrome 10.5 F5 SERPINC1
29 catastrophic antiphospholipid syndrome 10.5 APOH F5 MTHFR
30 intestinal impaction 10.5 F2 SERPINC1
31 cerebral sinovenous thrombosis 10.5 APOH F2 F5
32 fournier gangrene 10.5 F2 SERPINC1
33 cerebral palsy 10.5 F2 F5 MTHFR
34 leech infestation 10.4 F2 SERPINC1
35 buerger disease 10.4 APOH F2 MTHFR
36 raynaud phenomenon 10.4 APOH THBD
37 alpha-2-plasmin inhibitor deficiency 10.4 F2 SERPINC1
38 giant hemangioma 10.4 F2 SERPINC1
39 cerebrovascular disease 10.4 F2 F5 MTHFR
40 blue toe syndrome 10.4 F2 SERPINC1
41 intracranial embolism 10.4 F2 SERPINC1
42 anterior spinal artery syndrome 10.4 F2 SERPINC1
43 subendocardial myocardial infarction 10.4 F2 SERPINC1
44 scott syndrome 10.3 F2 F5
45 mild pre-eclampsia 10.3 FLT1 PGF
46 purpura fulminans 10.3 F2 SERPINC1
47 carotid artery occlusion 10.3 APOH F5 THBD
48 epithelioid hemangioendothelioma 10.3 FLT1 PGF
49 korean hemorrhagic fever 10.3 F2 SERPINC1
50 cancer-associated retinopathy 10.3 FLT1 PGF

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to Placental Abruption

Symptoms & Phenotypes for Placental Abruption

MGI Mouse Phenotypes related to Placental Abruption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 THBD SERPINC1 PGF F5 AGT FLT1
2 homeostasis/metabolism MP:0005376 10.06 THBD SERPINC1 PGF F5 AGT FLT1
3 growth/size/body region MP:0005378 10.02 THBD MTHFR F2 PGF F5 AGT
4 embryo MP:0005380 10.01 THBD SERPINC1 PGF F5 FLT1 ENG
5 immune system MP:0005387 9.86 SERPINC1 THBD F2 PGF AGT EBAG9
6 mortality/aging MP:0010768 9.65 SERPINC1 THBD MTHFR F2 F5 AGT
7 integument MP:0010771 9.63 THBD MTHFR F2 PGF F5 ENG
8 nervous system MP:0003631 9.28 THBD SERPINC1 F2 F5 AGT FLT1

Drugs & Therapeutics for Placental Abruption

Drugs for Placental Abruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 168)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4 555-30-6 38853
2
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-56-6 439302 53477758
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7487-88-9 24083
5
Labetalol Approved Phase 4 36894-69-6 3869
6
Nifedipine Approved Phase 4,Phase 3 21829-25-4 4485
7
Misoprostol Approved Phase 4 59122-46-2 5282381
8 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
9
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
11
Estrone Approved Phase 4 53-16-7 5870
12
Polyestradiol phosphate Approved Phase 4 28014-46-2
13
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
14
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
15
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
16 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Not Applicable
18 Micronutrients Phase 4,Phase 3,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 3
20 Tocolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
22 Hormone Antagonists Phase 4,Phase 3,Not Applicable
23 Trace Elements Phase 4,Phase 3,Not Applicable
24 Hormones Phase 4,Phase 3,Not Applicable
25 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
27 Vasodilator Agents Phase 4,Phase 2,Phase 3,Not Applicable
28 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
29 Vitamins Phase 4,Phase 3
30 Antihypertensive Agents Phase 4
31 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
32 calcium channel blockers Phase 4,Phase 3,Not Applicable
33 Clindamycin palmitate Phase 4
34 Clindamycin phosphate Phase 4
35 Anti-Arrhythmia Agents Phase 4,Phase 3,Not Applicable
36 Anti-Bacterial Agents Phase 4
37 Anticonvulsants Phase 4,Phase 3,Not Applicable
38 Anti-Infective Agents Phase 4,Phase 3
39 Adrenergic Agents Phase 4
40 Adrenergic alpha-1 Receptor Antagonists Phase 4
41 Adrenergic alpha-Antagonists Phase 4
42 Adrenergic Antagonists Phase 4
43 Adrenergic beta-Antagonists Phase 4
44 Gastrointestinal Agents Phase 4
45 Antacids Phase 4
46 Ergocalciferols Phase 4
47 Anti-Ulcer Agents Phase 4
48 Autonomic Agents Phase 4
49 Bone Density Conservation Agents Phase 4
50 Estropipate Phase 4 7280-37-7

Interventional clinical trials:

(show top 50) (show all 91)
# Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
3 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
4 Foley Bulb With Low Dose Pitocin Versus Foley Bulb With a Standard Incremental Infusion Protocol for the Induction of Labor Completed NCT02150954 Phase 4 pitocin
5 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
6 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4 Vaginal Misoprostol
7 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
8 NATural Ovarian Stimulation Active, not recruiting NCT02892942 Phase 4 Gonal-F®;Cetrotide®;Cetrotide®
9 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
10 Folic Acid Dosage and Malformations Reduction Unknown status NCT01244347 Phase 3 folic acid;folic acid
11 Impact of Analgesia on Success of External Version: Comparison of Spinal Anesthesia Versus Sedation Unknown status NCT02801201 Phase 3 Midazolam;Bupivacaine
12 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
13 Labor Induction and Maternal BMI, Comparison of Different Pre-induction Cervical Ripening Methods Unknown status NCT02223949 Phase 2, Phase 3 PGE1 tablet
14 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
15 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
16 Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor? Completed NCT01338454 Phase 3 transamin
17 Intraumbilical Vein Injection of Oxytocin in Routine Practice for Active Management of the Third Stage of Labor Completed NCT01094028 Phase 3 Oxytocin
18 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
19 Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion Completed NCT00959621 Phase 3 Aspirin;Klexane;Klexane and ASA
20 TIPPS: Thrombophilia in Pregnancy Prophylaxis Study Completed NCT00967382 Phase 3 dalteparin sodium
21 Controlled Cord Traction During Third Stage of Labor Completed NCT00781066 Phase 3
22 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
23 Effectiveness of Dalteparin Therapy as Intervention in Recurrent Pregnancy Loss Completed NCT00400387 Phase 3 Fragmin P Forte (dalteparin sodium)
24 Reinforcement-Based Treatment for Pregnant Drug Abusers Completed NCT01177982 Phase 2, Phase 3
25 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
26 RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil Completed NCT00097110 Phase 3 Vitamin C and E
27 Low Dose Aspirin in the Prevention of Preeclampsia in China Recruiting NCT02797249 Phase 3 Aspirin
28 Efficacy of Low Dose Levothyroxine During Pregnancy Recruiting NCT03391154 Phase 3 levothyroxin;Placebo Oral Tablet
29 Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) Recruiting NCT02932475 Phase 3 Metformin;Placebo
30 Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia Recruiting NCT02989025 Phase 3 17 OHPC
31 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
32 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
33 Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery Withdrawn NCT01796522 Phase 3 progesterone 200 mg / day vaginally;nifedipine (60 mg / day orally)
34 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
35 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
36 Early FETO for Severe Congenital Diaphragmatic Hernia Unknown status NCT01731509 Phase 2
37 Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies Completed NCT01355822 Phase 1, Phase 2 PETN;Placebo control
38 Intraumbilical Oxytocin Versus Placental Cord Drainage in the Management of 3rd Stage of Labor Recruiting NCT03395730 Phase 2 Intraumbilical vein injection oxytocin
39 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the GlaxoSmithKline (GSK) Biologicals' Respiratory Syncytial Virus (RSV) Investigational Vaccine (GSK3003891A) in Healthy Pregnant Women and Infants Born to Vaccinated Mothers Withdrawn NCT03191383 Phase 2 Placebo (Formulation buffer S9b)
40 Prophylactic Use of Intraumbilical Vein Oxytocin Injection in The Management of Third Stage of Labor Unknown status NCT02680938 Phase 1 oxytocin;saline
41 Spinal Analgesia Versus No Analgesia: Study for External Cephalic Version Terminated NCT00119184 Phase 1 spinal anesthesia
42 Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity Unknown status NCT00573118
43 Prediction of Preeclampsia & Other Obstetric Complications by Serum Homocysteine & Doppler Unknown status NCT02541110
44 The Prognosis of Early Pregnancy With Post Coital Bleeding Unknown status NCT02363569
45 Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy Unknown status NCT01335802
46 Haptoglobin and Diabetes Complications in Pregnancy Unknown status NCT01758016
47 Comparison of Efficiency Between Practicing of Knee Chest Position and External Cephalic Version in Cases of Breech Presentation. Unknown status NCT02167841 Not Applicable
48 Pre-Eclampsia Prediction By Doppler Screening Of Uterine Arteries And Angiogenic Factors In Second Trimester Of Pregnancy Unknown status NCT00725660
49 Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity Unknown status NCT01374477
50 Omission of Controlled Cord Traction During Active Management of Third Stage of Labor Unknown status NCT02656108 Not Applicable

Search NIH Clinical Center for Placental Abruption

Cochrane evidence based reviews: abortion, threatened

Genetic Tests for Placental Abruption

Anatomical Context for Placental Abruption

MalaCards organs/tissues related to Placental Abruption:

41
Placenta, Uterus, Kidney, Thyroid, Testes, Ovary, Cervix

Publications for Placental Abruption

Articles related to Placental Abruption:

(show top 50) (show all 367)
# Title Authors Year
1
Heat and pregnancy-related emergencies: Risk of placental abruption during hot weather. ( 29146008 )
2018
2
Placental abruption after amnioreduction for polyhydramnios caused by chorioangioma. ( 29507014 )
2018
3
Placental abruption: etiopathogenic aspects, diagnostic and therapeutic implications. ( 29940627 )
2018
4
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
5
Placenta previa and placental abruption after assisted reproductive technology in patients with endometriosis: a systematic review and meta-analysis. ( 29602980 )
2018
6
Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies. ( 29884306 )
2018
7
Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage. ( 29305829 )
2018
8
Placental Abruption (Abruptio Placentae) ( 29493960 )
2018
9
Advanced maternal age and its association with placenta praevia and placental abruption: a meta-analysis. ( 29489954 )
2018
10
Paraneoplastic renal cell carcinoma in the setting of preeclampsia and placental abruption. ( 29888194 )
2018
11
Exposures to Air Pollution and Risk of Acute-Onset Placental Abruption: A Case-Crossover Study. ( 29863531 )
2018
12
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity. ( 28594770 )
2017
13
Placental abruption leading to hysterectomy. ( 29233830 )
2017
14
Increased risk of placental abruption after solomon laser treatment of twin-twin transfusion syndrome. ( 28487021 )
2017
15
First-Trimester and Second-Trimester Maternal Serum Biomarkers as Predictors of Placental Abruption. ( 28178056 )
2017
16
Correction to: Clinical significance of primary symptoms in women with placental abruption. ( 28756712 )
2017
17
Placental abruption in parents who were born small: registry-based cohort study. ( 28755463 )
2017
18
Circadian Variation in the Onset of Placental Abruption. ( 28163931 )
2017
19
Seat Belt Sign as a Predictor of Placental Abruption. ( 29183513 )
2017
20
Core curriculum case illustration: placental abruption. ( 28439745 )
2017
21
Clinical significance of primary symptoms in women with placental abruption. ( 28629246 )
2017
22
Neonatal Outcomes Associated with Placental Abruption. ( 28595292 )
2017
23
Vaginal delivery after placental abruption with intrauterine fetal death: A 20-year single-center experience. ( 28370793 )
2017
24
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity. ( 29189681 )
2017
25
Mortality and causes of death among women with a history of placental abruption. ( 28832915 )
2017
26
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review. ( 28329897 )
2017
27
Cardiovascular Disease in Relation to Placental Abruption: AA Population-Based Cohort Study from Denmark. ( 28221677 )
2017
28
ASSOCIATION BETWEEN PLACENTAL ABRUPTION AND CAESAREAN SECTION AMONG PATIENTS AT KHYBER TEACHING HOSPITAL PESHAWAR. ( 27323587 )
2016
29
The Necessity of Awareness of Early Symptoms of Placental Abruption Among Pregnant Japanese Women. ( 27540442 )
2016
30
Placental genetic variations in circadian clock-related genes increase the risk of placental abruption. ( 27186326 )
2016
31
A Rare Cause of Placental Abruption: Uterine Torsion. ( 26894131 )
2016
32
Ambient PM2.5 Aluminum and Elemental Carbon and Placental Abruption Morbidity. ( 28002353 )
2016
33
Randomized, Double-Blinded Trial of Magnesium Sulfate Tocolysis versus Intravenous Normal Saline for Preterm Nonsevere Placental Abruption. ( 26871905 )
2016
34
Fetal cerebral and umbilical Doppler in pregnancies complicated by late-onset placental abruption. ( 27484964 )
2016
35
Does apoptotic activity have a role in the development of the placental abruption? ( 27893299 )
2016
36
Air Pollutant Exposure within a Few Days of Delivery and Placental Abruption in Japan. ( 27922526 )
2016
37
Placental Abruption Revealed by Hemoperitoneum: A Case Report. ( 27994944 )
2016
38
Trauma in pregnant women: assessing detection of post-traumatic placental abruption on contrast-enhanced CT versus ultrasound. ( 27853848 )
2016
39
Developmental outcomes in children following placental abruption: novel methods to disentangle causes and mediators. ( 27132247 )
2016
40
The role of mean platelet volume and platelet distribution width in the prediction of placental abruption. ( 27184035 )
2016
41
Pre-delivery fibrinogen predicts adverse maternal or neonatal outcomes in patients with placental abruption. ( 27075198 )
2016
42
Poster 46 Multiple Amputations Including Bilateral Transtibial Amputations in a 29-Year-Old Female After Suffering Placental Abruption, GBS Septicemia and DIC: AA Case Report. ( 27672813 )
2016
43
Placental abruption possibly due to parvovirus B19 infection. ( 27547655 )
2016
44
Use of uterine artery embolization toA prevent peripartum hemorrhage of placental abruption with fetal demise & severe DIC. ( 27589544 )
2016
45
Diagnosis of placental abruption: a legal issue for physicians. ( 26866304 )
2016
46
Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study. ( 27300725 )
2016
47
Circulating Levels of Pregnancy-Associated, Placenta-Specific microRNAs in Pregnant Women With Placental Abruption. ( 27297699 )
2016
48
Neurodevelopmental outcomes in children in relation to placental abruption. ( 27102365 )
2016
49
Rapid-Sequence Intubation in the Left-Lateral Tilt Position in a Pregnant Woman with Premature Placental Abruption Utilizing a Videolaryngoscope. ( 26199794 )
2015
50
[186-POS]: Role of coagulation factors in placental abruption in the Chinese population. ( 25787537 )
2015

Variations for Placental Abruption

Expression for Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for Placental Abruption

GO Terms for Placental Abruption

Cellular components related to Placental Abruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 AGT APOH F2 F5 FLT1 PGF
2 blood microparticle GO:0072562 9.33 AGT F2 SERPINC1
3 extracellular space GO:0005615 9.28 AGT APOH ENG F2 F5 FLT1

Biological processes related to Placental Abruption according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 AGT F2 FLT1 PGF
2 cellular protein metabolic process GO:0044267 9.77 F2 F5 SERPINC1
3 positive regulation of angiogenesis GO:0045766 9.71 ENG FLT1 PGF
4 female pregnancy GO:0007565 9.63 AGT PGF THBD
5 blood coagulation GO:0007596 9.62 F2 F5 SERPINC1 THBD
6 one-carbon metabolic process GO:0006730 9.58 MTHFD1 MTHFR
7 positive regulation of reactive oxygen species metabolic process GO:2000379 9.57 AGT F2
8 positive regulation of collagen biosynthetic process GO:0032967 9.56 ENG F2
9 folic acid metabolic process GO:0046655 9.55 MTHFD1 MTHFR
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.54 AGT F2 FLT1
11 blood coagulation, intrinsic pathway GO:0007597 9.52 APOH F2
12 negative regulation of blood coagulation GO:0030195 9.51 APOH THBD
13 positive regulation of blood coagulation GO:0030194 9.49 APOH F2
14 tetrahydrofolate interconversion GO:0035999 9.48 MTHFD1 MTHFR
15 negative regulation of platelet activation GO:0010544 9.43 F2 THBD
16 sprouting angiogenesis GO:0002040 9.43 ENG FLT1 PGF
17 methionine metabolic process GO:0006555 9.4 MTHFD1 MTHFR
18 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
19 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 THBD
20 hemostasis GO:0007599 8.92 F2 F5 SERPINC1 THBD

Molecular functions related to Placental Abruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 AGT F2 PGF
2 heparin binding GO:0008201 8.92 APOH F2 PGF SERPINC1

Sources for Placental Abruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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