MCID: PLC007
MIFTS: 51

Placental Abruption

Categories: Fetal diseases

Aliases & Classifications for Placental Abruption

MalaCards integrated aliases for Placental Abruption:

Name: Placental Abruption 12 76 15
Abruptio Placentae 12 55 44 73
Abortion, Threatened 44
Abruptio Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9667
ICD10 33 O20.0
ICD9CM 35 640.0 640.03
NCIt 50 C112857
SNOMED-CT 68 22689002 54048003

Summaries for Placental Abruption

Disease Ontology : 12 A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

MalaCards based summary : Placental Abruption, also known as abruptio placentae, is related to placenta disease and hellp syndrome. An important gene associated with Placental Abruption is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Methyldopa and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Placental abruption is when the placenta separates early from the uterus, in other words separates... more...

Related Diseases for Placental Abruption

Diseases related to Placental Abruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 placenta disease 31.6 APOH F5 MTHFR PGF SERPINC1
2 hellp syndrome 31.1 APOH ENG F2 F5 FLT1 MTHFR
3 cerebral palsy 30.4 F2 F5 MTHFR
4 disseminated intravascular coagulation 30.3 F2 F5 SERPINC1 THBD
5 placenta accreta 30.0 FLT1 PGF
6 dysfibrinogenemia 30.0 F2 F5 SERPINC1 THBD
7 severe pre-eclampsia 29.8 APOH F5 PGF SERPINC1
8 eclampsia 29.6 ENG F2 FLT1 MTHFR PGF SERPINC1
9 thrombophilia 29.6 APOH F2 F5 MTHFR SERPINC1 THBD
10 thrombosis 29.4 APOH F2 F5 MTHFR SERPINC1 THBD
11 pre-eclampsia 29.0 AGT APOH ENG F2 F5 FLT1
12 kidney cortex necrosis 11.6
13 preterm premature rupture of the membranes 10.3
14 inferior vena cava interruption 10.2 F5 MTHFR
15 paracetamol poisoning 10.2 F2 F5
16 amaurosis fugax 10.2 F5 MTHFR
17 may-thurner syndrome 10.2 APOH F5
18 supine hypotensive syndrome 10.2
19 appendicitis 10.2
20 mesenteric vascular occlusion 10.2 F2 MTHFR
21 acanthamoeba keratitis 10.2 APOH F5
22 hemoglobin e disease 10.2 F2 F5
23 pregnancy loss, recurrent 1 10.2 APOH F5
24 ischemic neuropathy 10.2 F2 MTHFR
25 factor viii deficiency 10.2 F2 F5
26 chorioamnionitis 10.2
27 placenta praevia 10.2
28 papilledema 10.2 APOH F2
29 arteritic anterior ischemic optic neuropathy 10.2 F2 F5 MTHFR
30 cryptogenic cirrhosis 10.2 F2 F5 MTHFR
31 porencephaly 10.2 F2 F5 MTHFR
32 gastroschisis 10.2 F2 F5 MTHFR
33 thrombasthenia 10.2 F2 F5 MTHFR
34 catastrophic antiphospholipid syndrome 10.1 APOH F5 MTHFR
35 sticky platelet syndrome 10.1 F5 SERPINC1
36 leech infestation 10.1 F2 SERPINC1
37 cerebral sinovenous thrombosis 10.1 APOH F2 F5
38 intestinal impaction 10.1 F2 SERPINC1
39 fournier gangrene 10.1 F2 SERPINC1
40 alpha-2-plasmin inhibitor deficiency 10.1 F2 SERPINC1
41 buerger disease 10.1 APOH F2 MTHFR
42 intracranial embolism 10.1 F2 SERPINC1
43 mild pre-eclampsia 10.1 FLT1 PGF
44 giant hemangioma 10.1 F2 SERPINC1
45 epithelioid hemangioendothelioma 10.1 FLT1 PGF
46 cerebrovascular disease 10.1 F2 F5 MTHFR
47 blue toe syndrome 10.1 F2 SERPINC1
48 subendocardial myocardial infarction 10.1 F2 SERPINC1
49 cancer-associated retinopathy 10.1 FLT1 PGF
50 raynaud phenomenon 10.1 APOH THBD

Graphical network of the top 20 diseases related to Placental Abruption:



Diseases related to Placental Abruption

Symptoms & Phenotypes for Placental Abruption

MGI Mouse Phenotypes related to Placental Abruption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 AGT ENG F2 F5 FLT1 MTHFD1
2 homeostasis/metabolism MP:0005376 10.06 AGT APOH ENG F2 F5 FLT1
3 growth/size/body region MP:0005378 10.02 AGT ENG F2 F5 FLT1 MTHFD1
4 embryo MP:0005380 10.01 ENG F2 F5 FLT1 MTHFD1 PGF
5 immune system MP:0005387 9.86 AGT EBAG9 F2 FLT1 MTHFD1 PGF
6 mortality/aging MP:0010768 9.65 AGT APOH ENG F2 F5 FLT1
7 integument MP:0010771 9.63 ENG F2 F5 MTHFR PGF THBD
8 nervous system MP:0003631 9.28 AGT ENG F2 F5 FLT1 MTHFD1

Drugs & Therapeutics for Placental Abruption

Drugs for Placental Abruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4 555-30-6 38853
2
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-56-6 439302 53477758
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
4
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
5
Misoprostol Approved Phase 4,Not Applicable 59122-46-2 5282381
6
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7487-88-9 24083
7
Nifedipine Approved Phase 4,Phase 3 21829-25-4 4485
8
Labetalol Approved Phase 4 36894-69-6 3869
9
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
10
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
11
Polyestradiol phosphate Approved Phase 4 28014-46-2
12 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
13
Estrone Approved Phase 4 53-16-7 5870
14
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
15
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
16
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
17 Antihypertensive Agents Phase 4
18 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Not Applicable
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
22 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
24 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
25 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
26 Antipyretics Phase 4,Phase 3,Phase 2,Not Applicable
27 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
29 Vasodilator Agents Phase 4,Phase 2,Phase 3,Not Applicable
30 Tocolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
31 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Vitamins Phase 4,Phase 3
33 Micronutrients Phase 4,Phase 3,Not Applicable
34 Trace Elements Phase 4,Phase 3,Not Applicable
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
36 Hormone Antagonists Phase 4,Phase 3,Not Applicable
37 Hormones Phase 4,Phase 3,Not Applicable
38 Clindamycin palmitate Phase 4
39 Anti-Infective Agents Phase 4,Phase 3
40 Anti-Bacterial Agents Phase 4
41 Clindamycin phosphate Phase 4
42 calcium channel blockers Phase 4,Phase 3,Not Applicable
43 Antacids Phase 4,Not Applicable
44 Anti-Ulcer Agents Phase 4,Not Applicable
45 Gastrointestinal Agents Phase 4,Not Applicable
46 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Not Applicable
47 Anti-Arrhythmia Agents Phase 4,Phase 3,Not Applicable
48 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
49 Anticonvulsants Phase 4,Phase 3,Not Applicable
50 Adrenergic beta-Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 104)
# Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
3 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
4 Foley Bulb With Low Dose Pitocin Versus Foley Bulb With a Standard Incremental Infusion Protocol for the Induction of Labor Completed NCT02150954 Phase 4 pitocin
5 Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
6 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
7 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4 Vaginal Misoprostol
8 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
9 NATural Ovarian Stimulation Active, not recruiting NCT02892942 Phase 4 Gonal-F®;Cetrotide®;Cetrotide®
10 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
11 Folic Acid Dosage and Malformations Reduction Unknown status NCT01244347 Phase 3 folic acid;folic acid
12 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
13 Labor Induction and Maternal BMI, Comparison of Different Pre-induction Cervical Ripening Methods Unknown status NCT02223949 Phase 2, Phase 3 PGE1 tablet
14 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
15 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
16 Bilateral Uterine Artery Ligation in Reducing Incidence of Postpartum Hemorrhage in Cesarean Section Completed NCT03591679 Phase 3 Oxytocin
17 Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor? Completed NCT01338454 Phase 3 transamin
18 Intraumbilical Vein Injection of Oxytocin in Routine Practice for Active Management of the Third Stage of Labor Completed NCT01094028 Phase 3 Oxytocin
19 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
20 Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion Completed NCT00959621 Phase 3 Aspirin;Klexane;Klexane and ASA
21 TIPPS: Thrombophilia in Pregnancy Prophylaxis Study Completed NCT00967382 Phase 3 dalteparin sodium
22 Controlled Cord Traction During Third Stage of Labor Completed NCT00781066 Phase 3
23 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
24 Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) Completed NCT00135707 Phase 3 Dietary Supplement/Vitamins;Placebo for Vitamin C and Vitamin E
25 Effectiveness of Dalteparin Therapy as Intervention in Recurrent Pregnancy Loss Completed NCT00400387 Phase 3 Fragmin P Forte (dalteparin sodium)
26 Reinforcement-Based Treatment for Pregnant Drug Abusers Completed NCT01177982 Phase 2, Phase 3
27 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
28 RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil Completed NCT00097110 Phase 3 Vitamin C and E
29 Low Dose Aspirin in the Prevention of Preeclampsia in China Recruiting NCT02797249 Phase 3 Aspirin
30 Impact of Analgesia on Success of External Version: Comparison of Spinal Anesthesia Versus Sedation Recruiting NCT02801201 Phase 3 Midazolam;Bupivacaine
31 Efficacy of Low Dose Levothyroxine During Pregnancy Recruiting NCT03391154 Phase 3 levothyroxin;Placebo Oral Tablet
32 Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) Recruiting NCT02932475 Phase 3 Metformin;Placebo
33 Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia Recruiting NCT02989025 Phase 3 17 OHPC
34 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
35 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
36 A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour Terminated NCT02292771 Phase 3 Retosiban;Atosiban;Placebo matching retosiban;Placebo matching atosiban
37 Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery Withdrawn NCT01796522 Phase 3 progesterone 200 mg / day vaginally;nifedipine (60 mg / day orally)
38 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
39 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
40 Early FETO for Severe Congenital Diaphragmatic Hernia Unknown status NCT01731509 Phase 2
41 Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies Completed NCT01355822 Phase 1, Phase 2 PETN;Placebo control
42 Intraumbilical Oxytocin Versus Placental Cord Drainage in the Management of 3rd Stage of Labor Recruiting NCT03395730 Phase 2 Intraumbilical vein injection oxytocin
43 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the GlaxoSmithKline (GSK) Biologicals' Respiratory Syncytial Virus (RSV) Investigational Vaccine (GSK3003891A) in Healthy Pregnant Women and Infants Born to Vaccinated Mothers Withdrawn NCT03191383 Phase 2 Placebo (Formulation buffer S9b)
44 Prophylactic Use of Intraumbilical Vein Oxytocin Injection in The Management of Third Stage of Labor Unknown status NCT02680938 Phase 1 oxytocin;saline
45 Spinal Analgesia Versus No Analgesia: Study for External Cephalic Version Terminated NCT00119184 Phase 1 spinal anesthesia
46 Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity Unknown status NCT00573118
47 Prediction of Preeclampsia & Other Obstetric Complications by Serum Homocysteine & Doppler Unknown status NCT02541110
48 The Prognosis of Early Pregnancy With Post Coital Bleeding Unknown status NCT02363569
49 Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy Unknown status NCT01335802
50 Haptoglobin and Diabetes Complications in Pregnancy Unknown status NCT01758016

Search NIH Clinical Center for Placental Abruption

Cochrane evidence based reviews: abruptio placentae

Genetic Tests for Placental Abruption

Anatomical Context for Placental Abruption

MalaCards organs/tissues related to Placental Abruption:

41
Placenta, Uterus, Kidney, Testes, Brain, Heart, Bone

Publications for Placental Abruption

Articles related to Placental Abruption:

(show top 50) (show all 723)
# Title Authors Year
1
Heat and pregnancy-related emergencies: Risk of placental abruption during hot weather. ( 29146008 )
2018
2
Placental abruption after amnioreduction for polyhydramnios caused by chorioangioma. ( 29507014 )
2018
3
Placental abruption: etiopathogenic aspects, diagnostic and therapeutic implications. ( 29940627 )
2018
4
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
5
Placenta previa and placental abruption after assisted reproductive technology in patients with endometriosis: a systematic review and meta-analysis. ( 29602980 )
2018
6
Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies. ( 29884306 )
2018
7
Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage. ( 29305829 )
2018
8
Placental Abruption (Abruptio Placentae) ( 29493960 )
2018
9
Advanced maternal age and its association with placenta praevia and placental abruption: a meta-analysis. ( 29489954 )
2018
10
Paraneoplastic renal cell carcinoma in the setting of preeclampsia and placental abruption. ( 29888194 )
2018
11
Exposures to Air Pollution and Risk of Acute-Onset Placental Abruption: A Case-Crossover Study. ( 29863531 )
2018
12
Abruptio Placentae Caused by Hypertriglyceridemia-Induced Acute Pancreatitis during Pregnancy: Case Report and Literature Review. ( 30254776 )
2018
13
Successful Pregnancy under Fibrinogen Substitution with Heparin and Aspirin in a Woman with Dysfibrinogenemia Revealed by Placental Abruption. ( 30296816 )
2018
14
Physical Exertion Immediately Prior to Placental Abruption: A Case-Crossover Study. ( 29992226 )
2018
15
Chahal et al. Respond to "Physical Exertion and Placental Abruption". ( 29992300 )
2018
16
Invited Commentary: Physical Exertion and Placental Abruption-Public Health Implications and Future Directions. ( 29992316 )
2018
17
Placental Abruption and Child Mortality. ( 30002139 )
2018
18
Placental abruption and hemorrhage-review of imaging appearance. ( 30159815 )
2018
19
Subsequent risk of cancer among women with a history of placental abruption. ( 30264633 )
2018
20
Placental abruption and long-term cardiovascular morbidity of the offspring. ( 30474712 )
2018
21
Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study. ( 30194050 )
2018
22
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity. ( 28594770 )
2017
23
Placental abruption leading to hysterectomy. ( 29233830 )
2017
24
Increased risk of placental abruption after solomon laser treatment of twin-twin transfusion syndrome. ( 28487021 )
2017
25
First-Trimester and Second-Trimester Maternal Serum Biomarkers as Predictors of Placental Abruption. ( 28178056 )
2017
26
Correction to: Clinical significance of primary symptoms in women with placental abruption. ( 28756712 )
2017
27
Placental abruption in parents who were born small: registry-based cohort study. ( 28755463 )
2017
28
Circadian Variation in the Onset of Placental Abruption. ( 28163931 )
2017
29
Seat Belt Sign as a Predictor of Placental Abruption. ( 29183513 )
2017
30
Core curriculum case illustration: placental abruption. ( 28439745 )
2017
31
Clinical significance of primary symptoms in women with placental abruption. ( 28629246 )
2017
32
Neonatal Outcomes Associated with Placental Abruption. ( 28595292 )
2017
33
Vaginal delivery after placental abruption with intrauterine fetal death: A 20-year single-center experience. ( 28370793 )
2017
34
Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity. ( 29189681 )
2017
35
Abruptio Placentae with Type II Respiratory Failure Secondary to Acute Interstitial Pneumonia Responsive to Steroids. ( 28969741 )
2017
36
Mortality and causes of death among women with a history of placental abruption. ( 28832915 )
2017
37
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review. ( 28329897 )
2017
38
Cardiovascular Disease in Relation to Placental Abruption: AA Population-Based Cohort Study from Denmark. ( 28221677 )
2017
39
Seat Belt Sign as a Predictor of Placental Abruption. ( 30454235 )
2017
40
Purtscher-like Retinopathy After Placental Abruption. ( 29999296 )
2017
41
Abruptio Placentae. ( 28556865 )
2017
42
ASSOCIATION BETWEEN PLACENTAL ABRUPTION AND CAESAREAN SECTION AMONG PATIENTS AT KHYBER TEACHING HOSPITAL PESHAWAR. ( 27323587 )
2016
43
The Necessity of Awareness of Early Symptoms of Placental Abruption Among Pregnant Japanese Women. ( 27540442 )
2016
44
Placental genetic variations in circadian clock-related genes increase the risk of placental abruption. ( 27186326 )
2016
45
A Rare Cause of Placental Abruption: Uterine Torsion. ( 26894131 )
2016
46
Ambient PM2.5 Aluminum and Elemental Carbon and Placental Abruption Morbidity. ( 28002353 )
2016
47
Randomized, Double-Blinded Trial of Magnesium Sulfate Tocolysis versus Intravenous Normal Saline for Preterm Nonsevere Placental Abruption. ( 26871905 )
2016
48
Fetal cerebral and umbilical Doppler in pregnancies complicated by late-onset placental abruption. ( 27484964 )
2016
49
Does apoptotic activity have a role in the development of the placental abruption? ( 27893299 )
2016
50
Air Pollutant Exposure within a Few Days of Delivery and Placental Abruption in Japan. ( 27922526 )
2016

Variations for Placental Abruption

Expression for Placental Abruption

Search GEO for disease gene expression data for Placental Abruption.

Pathways for Placental Abruption

Pathways related to Placental Abruption according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 APOH F2 F5 SERPINC1 THBD
2
Show member pathways
12.34 F2 F5 SERPINC1 THBD
3
Show member pathways
11.88 F2 MTHFD1 MTHFR
4
Show member pathways
11.46 F2 F5 SERPINC1 THBD
5 11.07 F2 F5 SERPINC1 THBD
6 10.67 FLT1 SERPINC1
7
Show member pathways
10.36 FLT1 PGF

GO Terms for Placental Abruption

Cellular components related to Placental Abruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 AGT APOH F2 F5 FLT1 PGF
2 blood microparticle GO:0072562 9.33 AGT F2 SERPINC1
3 extracellular space GO:0005615 9.28 AGT APOH ENG F2 F5 FLT1

Biological processes related to Placental Abruption according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 AGT F2 FLT1 PGF
2 cellular protein metabolic process GO:0044267 9.79 F2 F5 SERPINC1
3 positive regulation of protein phosphorylation GO:0001934 9.76 ENG F2 PGF
4 positive regulation of angiogenesis GO:0045766 9.73 ENG FLT1 PGF
5 blood circulation GO:0008015 9.62 F5 MTHFR
6 female pregnancy GO:0007565 9.61 AGT PGF THBD
7 sprouting angiogenesis GO:0002040 9.6 ENG PGF
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.59 AGT F2
9 positive regulation of collagen biosynthetic process GO:0032967 9.58 ENG F2
10 one-carbon metabolic process GO:0006730 9.57 MTHFD1 MTHFR
11 blood coagulation GO:0007596 9.56 F2 F5 SERPINC1 THBD
12 folic acid metabolic process GO:0046655 9.55 MTHFD1 MTHFR
13 blood coagulation, intrinsic pathway GO:0007597 9.54 APOH F2
14 vascular endothelial growth factor signaling pathway GO:0038084 9.52 FLT1 PGF
15 negative regulation of blood coagulation GO:0030195 9.51 APOH THBD
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.5 AGT F2 FLT1
17 positive regulation of blood coagulation GO:0030194 9.49 APOH F2
18 methionine biosynthetic process GO:0009086 9.48 MTHFD1 MTHFR
19 tetrahydrofolate interconversion GO:0035999 9.46 MTHFD1 MTHFR
20 negative regulation of platelet activation GO:0010544 9.4 F2 THBD
21 methionine metabolic process GO:0006555 9.37 MTHFD1 MTHFR
22 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
23 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 THBD
24 hemostasis GO:0007599 8.92 F2 F5 SERPINC1 THBD

Molecular functions related to Placental Abruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.33 ENG FLT1 THBD
2 growth factor activity GO:0008083 9.13 AGT F2 PGF
3 heparin binding GO:0008201 8.92 APOH F2 PGF SERPINC1

Sources for Placental Abruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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