MCID: PLC006
MIFTS: 33

Placental Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Placental Choriocarcinoma

MalaCards integrated aliases for Placental Choriocarcinoma:

Name: Placental Choriocarcinoma 12 15 17 72
Choriocarcinoma of the Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2024
NCIt 50 C8893
UMLS 72 C0855173

Summaries for Placental Choriocarcinoma

Disease Ontology : 12 A gestational choriocarcinoma that is located in the placenta.

MalaCards based summary : Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to gestational choriocarcinoma and choriocarcinoma. An important gene associated with Placental Choriocarcinoma is ABCG2 (ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)), and among its related pathways/superpathways are Glucose / Energy Metabolism and Adipogenesis. Affiliated tissues include placenta, brain and liver, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Placental Choriocarcinoma

Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to Placental Choriocarcinoma

Symptoms & Phenotypes for Placental Choriocarcinoma

MGI Mouse Phenotypes related to Placental Choriocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ABCG2 DKK1 FABP3 LEP MAF MTHFD1
2 behavior/neurological MP:0005386 9.87 ABCG2 FABP3 LEP MAF PLIN1 PLIN2
3 adipose tissue MP:0005375 9.77 ABCG2 FABP3 LEP PLIN1 PLIN2
4 integument MP:0010771 9.63 ABCG2 LEP MAF PLIN1 PLIN2 SLC6A4
5 liver/biliary system MP:0005370 9.35 ABCG2 FABP3 LEP PLIN1 PLIN2
6 renal/urinary system MP:0005367 9.02 ABCG2 DKK1 LEP MAF SLC22A2

Drugs & Therapeutics for Placental Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Placental Choriocarcinoma

Genetic Tests for Placental Choriocarcinoma

Anatomical Context for Placental Choriocarcinoma

MalaCards organs/tissues related to Placental Choriocarcinoma:

41
Placenta, Brain, Liver, Breast, Endothelial, Kidney, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Placental Choriocarcinoma:

19
Placenta

Publications for Placental Choriocarcinoma

Articles related to Placental Choriocarcinoma:

(show top 50) (show all 175)
# Title Authors PMID Year
1
The BeWo cell line derived from a human placental choriocarcinoma is permissive for respiratory syncytial virus infection. 38
30758769 2019
2
BDE-47 Decreases Progesterone Levels in BeWo Cells by Interfering with Mitochondrial Functions and Genes Related to Cholesterol Transport. 38
30714368 2019
3
The Possible Involvement of miR-371a-5p Regulating XIAP in the Pathogenesis of Recurrent Pregnancy Loss. 38
30819044 2019
4
Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells. 38
30629581 2019
5
Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells. 38
30712664 2019
6
Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients. 38
30369548 2019
7
Naringenin suppresses growth of human placental choriocarcinoma via reactive oxygen species-mediated P38 and JNK MAPK pathways. 38
30466984 2018
8
Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles. 38
30295666 2018
9
Development of serotonin transporter reuptake inhibition assays using JAR cells. 38
29555537 2018
10
Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells. 38
29223574 2018
11
Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells under hypoxia. 38
29765448 2018
12
Coumestrol induces mitochondrial dysfunction by stimulating ROS production and calcium ion influx into mitochondria in human placental choriocarcinoma cells. 38
29040664 2017
13
Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia. 38
27770612 2017
14
Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress. 38
28428076 2017
15
Treatment of Human Placental Choriocarcinoma Cells with Formaldehyde and Benzene Induced Growth and Epithelial Mesenchymal Transition via Induction of an Antioxidant Effect. 38
28758930 2017
16
The heat shock protein 60 promotes progesterone synthesis in mitochondria of JEG-3 cells. 38
28434777 2017
17
Regulation of the placental BCRP transporter by PPAR gamma. 38
27879033 2017
18
Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. 38
28515017 2017
19
Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate. 38
28282128 2017
20
Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells. 38
27818298 2017
21
Glucocorticoid receptor-mediated insulin-like growth factor-I transcriptional regulation in BeWo trophoblast cells before and after syncytialisation. 38
27500692 2016
22
Corrigendum to "Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (Bewo) cells" [Placenta (2009) 1037-1044]. 38
27623544 2016
23
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity. 38
27580988 2016
24
Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. 38
27580989 2016
25
Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. 38
27556547 2016
26
Dose-dependent and cell type-specific cell death and proliferation following in vitro exposure to radial extracorporeal shock waves. 38
27477873 2016
27
Green tea (-)-epigallocatechin gallate induced growth inhibition of human placental choriocarcinoma cells. 38
27208402 2016
28
Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter. 38
26850786 2016
29
The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells. 38
26232936 2016
30
Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells. 38
26094588 2016
31
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. 38
26917260 2016
32
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations. 38
26383631 2015
33
Toxicity of diuron in human cancer cells. 38
26086120 2015
34
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. 38
26343016 2015
35
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells. 38
26299783 2015
36
Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function. 38
25982682 2015
37
Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. 38
26014898 2015
38
Chemometric strategy for untargeted lipidomics: biomarker detection and identification in stressed human placental cells. 38
25479864 2015
39
Decreased placental miR-126 expression and vascular endothelial growth factor levels in patients with pre-eclampsia. 38
25341970 2014
40
Characterization of complex lipid mixtures in contaminant exposed JEG-3 cells using liquid chromatography and high-resolution mass spectrometry. 38
24969426 2014
41
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells. 38
24969759 2014
42
Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down. 38
24623739 2014
43
Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells. 38
24680846 2014
44
miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. 38
22564678 2013
45
The impact of TGF-β1 on the mRNA expression of TβR I, TβR II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. 38
23205135 2012
46
A monoclonal antibody against leptin. 38
23098305 2012
47
Primary hepatic choriocarcinoma: a rare cause of spontaneous haemoperitoneum in an adult. 38
24765472 2012
48
Divalent metal transporter 1 expression and regulation in human placenta. 38
21947861 2012
49
Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance. 38
22113078 2012
50
In vitro placental model optimization for nanoparticle transport studies. 38
22334780 2012

Variations for Placental Choriocarcinoma

Expression for Placental Choriocarcinoma

Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for Placental Choriocarcinoma

GO Terms for Placental Choriocarcinoma

Biological processes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 9.37 MTR MTHFD1
2 long-chain fatty acid transport GO:0015909 9.26 PLIN2 FABP3
3 neurotransmitter biosynthetic process GO:0042136 9.16 SLC6A4 SLC22A2
4 drug transmembrane transport GO:0006855 9.02 SLC22A2
5 methionine biosynthetic process GO:0009086 8.96 MTR MTHFD1
6 response to drug GO:0042493 8.8 SLC6A4 PLIN2 FABP3

Sources for Placental Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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