MCID: PLC006
MIFTS: 36

Placental Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Placental Choriocarcinoma

MalaCards integrated aliases for Placental Choriocarcinoma:

Name: Placental Choriocarcinoma 12 15 17 71
Choriocarcinoma of the Placenta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2024
NCIt 49 C8893
UMLS 71 C0855173

Summaries for Placental Choriocarcinoma

Disease Ontology : 12 A gestational choriocarcinoma that is located in the placenta.

MalaCards based summary : Placental Choriocarcinoma, also known as choriocarcinoma of the placenta, is related to choriocarcinoma and vascular disease. An important gene associated with Placental Choriocarcinoma is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Prolactin Signaling Pathway. Affiliated tissues include placenta, liver and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Placental Choriocarcinoma

Diseases related to Placental Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 31.3 SLC6A4 GPC3 ERVW-1 ABCG2
2 vascular disease 29.0 SLC6A4 NFE2L2 LEP INS ALB
3 aryl hydrocarbon hydroxylase inducibility 10.4 CYP1A1 AHR
4 hypothalamic obesity 10.4 LEP INS
5 cholera 10.2
6 sleep disorder 10.2 SLC6A4 LEP INS
7 serous labyrinthitis 10.2 ERVW-1 ALB
8 enteropathica 10.2 PLIN2 ALB
9 toxic oil syndrome 10.2 CYP1A1 AHR
10 bulimia nervosa 10.2 SLC6A4 LEP INS
11 fibromyalgia 10.1 SLC6A4 LEP INS
12 insulin-like growth factor i 10.1 LEP INS AKT1
13 maturity-onset diabetes of the young, type 1 10.1 LEP INS ALB
14 critical illness polyneuropathy 10.1 INS ALB
15 pigmentation disease 10.1 LEP INS ALB
16 apnea, obstructive sleep 10.1 LEP INS ALB
17 prediabetes syndrome 10.1 LEP INS ALB
18 sexual disorder 10.1 SLC6A4 INS ALB
19 diffuse idiopathic skeletal hyperostosis 10.1 INS DKK1 ALB
20 pre-eclampsia 10.1
21 cholelithiasis 10.1 LEP INS ALB
22 pica disease 10.1 MAF ALB
23 mitral valve disease 10.0 SLC6A4 RPS6KB1 AKT1
24 hypotrichosis 1 10.0 INS ALB AKT1
25 toxic encephalopathy 10.0 SLC6A4 ALB AKT1 ABCG2
26 eating disorder 10.0 SLC6A4 LEP ALB
27 hair disease 10.0 INS ALB AKT1
28 retinal vascular disease 10.0 INS ALB AKT1
29 inflammatory and toxic neuropathy 10.0 INS ALB
30 leptin deficiency or dysfunction 10.0 LEP INS ALB
31 exudative vitreoretinopathy 1 10.0 INS ALB AKT1
32 persistent fetal circulation syndrome 10.0 LEP INS ALB ABCG2
33 hyperuricemia 10.0 LEP INS ALB ABCG2
34 generalized atherosclerosis 10.0 INS ALB
35 metachromatic leukodystrophy 10.0 SLC6A4 INS ALB
36 sleep apnea 10.0 SLC6A4 LEP INS ALB
37 specific developmental disorder 9.9 SLC6A4 LEP INS ALB
38 uremia 9.9 LEP INS ALB
39 bone remodeling disease 9.9 LEP INS DKK1 ALB
40 endocrine pancreas disease 9.9 LEP INS ALB AKT1
41 pancreas disease 9.9 LEP INS ALB AKT1
42 lipid storage disease 9.9 LEP INS ALB
43 disease of mental health 9.9 SLC6A4 LEP INS ALB
44 ectopic pregnancy 9.9
45 pertussis 9.9
46 eclampsia 9.9
47 gestational choriocarcinoma 9.9
48 glioblastoma multiforme 9.9
49 trophoblastic neoplasm 9.9
50 placenta disease 9.9

Graphical network of the top 20 diseases related to Placental Choriocarcinoma:



Diseases related to Placental Choriocarcinoma

Symptoms & Phenotypes for Placental Choriocarcinoma

GenomeRNAi Phenotypes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.62 AHR ERVW-1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.62 AHR
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.62 SLC6A4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.62 NFE2L2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.62 AHR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.62 AHR
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.62 AHR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.62 AHR
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.62 SLC6A4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.62 ERVW-1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.62 SLC6A4
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.62 AHR
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.62 NFE2L2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.62 AHR ERVW-1 NFE2L2 SLC6A4
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.62 SLC6A4
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.62 SLC6A4

MGI Mouse Phenotypes related to Placental Choriocarcinoma:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ABCG2 AHR AKT1 ALB CYP1A1 DKK1
2 cellular MP:0005384 10.32 ABCG2 AHR AKT1 ALB DKK1 FABP3
3 cardiovascular system MP:0005385 10.3 AHR AKT1 ALB CYP1A1 FABP3 GPC3
4 growth/size/body region MP:0005378 10.29 AHR AKT1 CYP1A1 DKK1 GPC3 INS
5 behavior/neurological MP:0005386 10.28 ABCG2 AHR AKT1 FABP3 INS LEP
6 immune system MP:0005387 10.28 ABCG2 AHR AKT1 ALB CYP1A1 GPC3
7 hematopoietic system MP:0005397 10.23 ABCG2 AHR AKT1 CYP1A1 GPC3 INS
8 adipose tissue MP:0005375 10.2 ABCG2 AKT1 FABP3 INS LEP NFE2L2
9 endocrine/exocrine gland MP:0005379 10.19 AHR AKT1 ALB CYP1A1 INS LEP
10 mortality/aging MP:0010768 10.13 AHR AKT1 ALB CYP1A1 DKK1 FABP3
11 integument MP:0010771 10.07 ABCG2 AHR AKT1 GPC3 INS LEP
12 liver/biliary system MP:0005370 10.06 ABCG2 AHR AKT1 ALB CYP1A1 FABP3
13 muscle MP:0005369 9.76 AHR AKT1 ALB FABP3 INS LEP
14 nervous system MP:0003631 9.7 ABCG2 AHR AKT1 DKK1 INS LEP
15 renal/urinary system MP:0005367 9.32 ABCG2 AHR ALB DKK1 GPC3 INS

Drugs & Therapeutics for Placental Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Placental Choriocarcinoma

Genetic Tests for Placental Choriocarcinoma

Anatomical Context for Placental Choriocarcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Placental Choriocarcinoma:

19
Placenta

MalaCards organs/tissues related to Placental Choriocarcinoma:

40
Placenta, Liver, Breast, Kidney, Bone, Brain, Pancreas

Publications for Placental Choriocarcinoma

Articles related to Placental Choriocarcinoma:

(show top 50) (show all 175)
# Title Authors PMID Year
1
The Possible Involvement of miR-371a-5p Regulating XIAP in the Pathogenesis of Recurrent Pregnancy Loss. 61
30819044 2019
2
The BeWo cell line derived from a human placental choriocarcinoma is permissive for respiratory syncytial virus infection. 61
30758769 2019
3
BDE-47 Decreases Progesterone Levels in BeWo Cells by Interfering with Mitochondrial Functions and Genes Related to Cholesterol Transport. 61
30714368 2019
4
Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients. 61
30369548 2019
5
Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells. 61
30712664 2019
6
Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells. 61
30629581 2019
7
Naringenin suppresses growth of human placental choriocarcinoma via reactive oxygen species-mediated P38 and JNK MAPK pathways. 61
30466984 2018
8
Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles. 61
30295666 2018
9
Development of serotonin transporter reuptake inhibition assays using JAR cells. 61
29555537 2018
10
Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells under hypoxia. 61
29765448 2018
11
Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells. 61
29223574 2018
12
Coumestrol induces mitochondrial dysfunction by stimulating ROS production and calcium ion influx into mitochondria in human placental choriocarcinoma cells. 61
29040664 2017
13
Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia. 61
27770612 2017
14
Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress. 61
28428076 2017
15
Treatment of Human Placental Choriocarcinoma Cells with Formaldehyde and Benzene Induced Growth and Epithelial Mesenchymal Transition via Induction of an Antioxidant Effect. 61
28758930 2017
16
The heat shock protein 60 promotes progesterone synthesis in mitochondria of JEG-3 cells. 61
28434777 2017
17
Regulation of the placental BCRP transporter by PPAR gamma. 61
27879033 2017
18
Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. 61
28515017 2017
19
Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate. 61
28282128 2017
20
Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells. 61
27818298 2017
21
Glucocorticoid receptor-mediated insulin-like growth factor-I transcriptional regulation in BeWo trophoblast cells before and after syncytialisation. 61
27500692 2016
22
Corrigendum to "Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (Bewo) cells" [Placenta (2009) 1037-1044]. 61
27623544 2016
23
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity. 61
27580988 2016
24
Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. 61
27580989 2016
25
Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. 61
27556547 2016
26
Dose-dependent and cell type-specific cell death and proliferation following in vitro exposure to radial extracorporeal shock waves. 61
27477873 2016
27
Green tea (-)-epigallocatechin gallate induced growth inhibition of human placental choriocarcinoma cells. 61
27208402 2016
28
Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter. 61
26850786 2016
29
The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells. 61
26232936 2016
30
Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells. 61
26094588 2016
31
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. 61
26917260 2016
32
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations. 61
26383631 2015
33
Toxicity of diuron in human cancer cells. 61
26086120 2015
34
Quantification of new antiepileptic drugs by liquid chromatography/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. 61
26343016 2015
35
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells. 61
26299783 2015
36
Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function. 61
25982682 2015
37
Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. 61
26014898 2015
38
Chemometric strategy for untargeted lipidomics: biomarker detection and identification in stressed human placental cells. 61
25479864 2015
39
Decreased placental miR-126 expression and vascular endothelial growth factor levels in patients with pre-eclampsia. 61
25341970 2014
40
Characterization of complex lipid mixtures in contaminant exposed JEG-3 cells using liquid chromatography and high-resolution mass spectrometry. 61
24969426 2014
41
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells. 61
24969759 2014
42
Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down. 61
24623739 2014
43
Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells. 61
24680846 2014
44
miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. 61
22564678 2013
45
The impact of TGF-β1 on the mRNA expression of TβR I, TβR II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. 61
23205135 2012
46
A monoclonal antibody against leptin. 61
23098305 2012
47
Primary hepatic choriocarcinoma: a rare cause of spontaneous haemoperitoneum in an adult. 61
24765472 2012
48
Divalent metal transporter 1 expression and regulation in human placenta. 61
21947861 2012
49
Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance. 61
22113078 2012
50
In vitro placental model optimization for nanoparticle transport studies. 61
22334780 2012

Variations for Placental Choriocarcinoma

Expression for Placental Choriocarcinoma

Search GEO for disease gene expression data for Placental Choriocarcinoma.

Pathways for Placental Choriocarcinoma

Pathways related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 RPS6KB1 INS GPC3 AKT1
2
Show member pathways
12.29 RPS6KB1 LEP INS AKT1
3
Show member pathways
12.24 RPS6KB1 LEP INS AKT1
4
Show member pathways
12.2 SLC22A2 RPS6KB1 INS AKT1
5
Show member pathways
12.03 RPS6KB1 LEP INS AKT1
6 11.74 PLIN2 LEP INS AHR
7 11.59 SLC1A5 PGRMC1 INS FABP3 AKT1 ABCG2
8
Show member pathways
11.47 SLC6A4 SLC22A2 CYP1A1 ABCG2
9 11.35 LEP INS AKT1
10 11.31 NFE2L2 CYP1A1 AHR
11 11.29 NFE2L2 CYP1A1 AHR
12 11.22 INS ALB AKT1
13 11.18 RPS6KB1 INS AKT1
14 11.07 PLIN2 LEP AKT1 ABCG2
15
Show member pathways
10.96 SLC22A2 CYP1A1 ABCG2
16 10.72 NFE2L2 MAF

GO Terms for Placental Choriocarcinoma

Biological processes related to Placental Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 RPS6KB1 LEP DKK1 ALB AKT1
2 response to toxic substance GO:0009636 9.71 SLC6A4 CYP1A1 AHR
3 response to organic substance GO:0010033 9.67 SLC6A4 CYP1A1 AKT1
4 positive regulation of gene expression GO:0010628 9.63 SLC6A4 NFE2L2 MAF INS DKK1 AKT1
5 aging GO:0007568 9.62 RPS6KB1 NFE2L2 CYP1A1 AKT1
6 response to nutrient GO:0007584 9.61 SLC6A4 RPS6KB1 LEP
7 glucose metabolic process GO:0006006 9.54 LEP INS AKT1
8 neurotransmitter biosynthetic process GO:0042136 9.52 SLC6A4 SLC22A2
9 positive regulation of lipid biosynthetic process GO:0046889 9.48 INS AKT1
10 long-chain fatty acid transport GO:0015909 9.46 PLIN2 FABP3
11 positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 9.4 GPC3 DKK1
12 negative regulation of protein oligomerization GO:0032460 9.26 INS ALB
13 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.13 NFE2L2 INS AKT1
14 positive regulation of glucose import GO:0046326 8.92 NFE2L2 INS GPC3 AKT1

Sources for Placental Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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