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MCID: PLC005
MIFTS: 57

Placental Insufficiency

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Placental Insufficiency

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MalaCards integrated aliases for Placental Insufficiency:

Name: Placental Insufficiency 12 60 56 45 15 17 74
Uteroplacental Vascular Insufficiency 60

Characteristics:

Orphanet epidemiological data:

60
placental insufficiency
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Reproductive diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare gynaecological and obstetric diseases


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Summaries for Placental Insufficiency

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Disease Ontology : 12 A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

MalaCards based summary : Placental Insufficiency, also known as uteroplacental vascular insufficiency, is related to eclampsia and severe pre-eclampsia. An important gene associated with Placental Insufficiency is PGF (Placental Growth Factor), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Aspirin and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related phenotypes are intrauterine growth retardation and hypoxemia

Wikipedia : 77 Placental insufficiency or utero-placental insufficiency is the failure of the placenta to deliver... more...

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Related Diseases for Placental Insufficiency

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Diseases related to Placental Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 eclampsia 30.6 F2 FLT1 PGF
2 severe pre-eclampsia 29.5 APLN FGR LEP PGF VEGFA
3 hellp syndrome 29.2 F2 F3 FLT1 PGF
4 pre-eclampsia 28.8 AFP F2 F3 FLT1 KDR LEP
5 cholestasis, intrahepatic, of pregnancy, 1 11.2
6 cholestasis, intrahepatic, of pregnancy 3 11.2
7 glomeruloid hemangioma 10.4 FLT1 VEGFA
8 microcystic meningioma 10.4 FLT1 VEGFA
9 sick building syndrome 10.4 LEP VEGFA
10 hematocele of tunica vaginalis testis 10.3 AFP ANGPT2
11 neovascular glaucoma 10.3 PGF VEGFA
12 patau syndrome 10.3 AFP PGF
13 critical limb ischemia 10.3 TEK VEGFA
14 kuhnt-junius degeneration 10.3 PGF VEGFA
15 cancer-associated retinopathy 10.3 FLT1 PGF VEGFA
16 mild pre-eclampsia 10.3 FLT1 LEP PGF
17 chronic myocardial ischemia 10.3 TEK VEGFA
18 angiodysplasia 10.3 ANGPT2 VEGFA
19 twin-to-twin transfusion syndrome 10.3 ANGPT2 FLT1 PGF
20 lipodermatosclerosis 10.3 ANGPT2 FLT1 VEGFA
21 background diabetic retinopathy 10.2 ANGPT2 VEGFA
22 endometrial small cell carcinoma 10.2 AFP F2
23 microvascular complications of diabetes 1 10.2 ANGPT2 FLT1 VEGFA
24 ischemic colitis 10.2 F2 VEGFA
25 ovarian cyst 10.2 AFP VEGFA
26 balanitis xerotica obliterans 10.2 APLN VEGFA
27 pyogenic granuloma 10.2 ANGPT2 TEK VEGFA
28 placental abruption 10.2 F2 FLT1 PGF
29 retinal vascular occlusion 10.2 F2 PGF VEGFA
30 peliosis hepatis 10.1 AFP F2 VEGFA
31 hypoxia 10.1
32 intermittent claudication 10.1 ANGPT2 F2 VEGFA
33 gastrointestinal system disease 10.1 AFP F2 VEGFA
34 radiation proctitis 10.1 KDR VEGFA
35 angiokeratoma circumscriptum 10.1 FLT1 KDR VEGFA
36 skin hemangioma 10.1 FLT1 KDR VEGFA
37 vascular cancer 10.1 FLT1 KDR VEGFA
38 epileptic encephalopathy, childhood-onset 10.0 ANGPT2 KDR VEGFA
39 autism 10.0
40 bladder neck obstruction 10.0 AFP F3
41 cerebral falx meningioma 10.0 F2 F3
42 leech infestation 10.0 F2 F3
43 epithelioid hemangioendothelioma 10.0 FLT1 KDR PGF VEGFA
44 prothrombin deficiency 10.0 F2 F3
45 intestinal impaction 10.0 F2 F3
46 fournier gangrene 9.9 F2 F3
47 retinal vascular disease 9.9 FLT1 KDR PGF VEGFA
48 cerebral sinovenous thrombosis 9.9 F2 F3
49 qualitative platelet defect 9.9 F2 F3
50 giant hemangioma 9.9 F2 F3

Graphical network of the top 20 diseases related to Placental Insufficiency:



Diseases related to Placental Insufficiency
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Symptoms & Phenotypes for Placental Insufficiency

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Human phenotypes related to Placental Insufficiency:

60 33 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 60 33 hallmark (90%) Very frequent (99-80%) HP:0001511
2 hypoxemia 60 33 hallmark (90%) Very frequent (99-80%) HP:0012418
3 small for gestational age 60 33 hallmark (90%) Very frequent (99-80%) HP:0001518
4 small placenta 60 33 hallmark (90%) Very frequent (99-80%) HP:0006266
5 proportionate short stature 60 33 hallmark (90%) Very frequent (99-80%) HP:0003508
6 abnormal umbilical cord blood vessels 60 33 hallmark (90%) Very frequent (99-80%) HP:0011403
7 autism 60 33 frequent (33%) Frequent (79-30%) HP:0000717
8 neurodevelopmental abnormality 60 33 frequent (33%) Frequent (79-30%) HP:0012759
9 systemic lupus erythematosus 60 33 frequent (33%) Frequent (79-30%) HP:0002725
10 antiphospholipid antibody positivity 60 33 frequent (33%) Frequent (79-30%) HP:0003613
11 preeclampsia 60 33 occasional (7.5%) Occasional (29-5%) HP:0100602
12 cerebral palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0100021
13 spontaneous abortion 60 33 occasional (7.5%) Occasional (29-5%) HP:0005268
14 insulin resistance 60 33 occasional (7.5%) Occasional (29-5%) HP:0000855
15 abnormal heart morphology 60 33 occasional (7.5%) Occasional (29-5%) HP:0001627
16 eclampsia 60 33 occasional (7.5%) Occasional (29-5%) HP:0100601
17 maternal hypertension 60 33 occasional (7.5%) Occasional (29-5%) HP:0008071
18 abnormal lung morphology 33 occasional (7.5%) HP:0002088
19 abnormality of lung morphology 60 Occasional (29-5%)
20 autistic behavior 60 Frequent (79-30%)
21 abnormality of the placenta 60 Obligate (100%)

GenomeRNAi Phenotypes related to Placental Insufficiency according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.8 FGR FLT1 TEK

MGI Mouse Phenotypes related to Placental Insufficiency:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 ANGPT2 APLN EMP2 F2 F3 FGR
2 homeostasis/metabolism MP:0005376 10.23 AFP ANGPT2 APLN F2 F3 FLT1
3 embryo MP:0005380 10.21 APLN EMP2 F2 F3 FLT1 KDR
4 behavior/neurological MP:0005386 10.19 AFP APLN F2 F3 FLT1 KDR
5 growth/size/body region MP:0005378 10.19 APLN F2 F3 FLT1 KDR LEP
6 hematopoietic system MP:0005397 10.13 EMP2 F2 F3 FGR FLT1 KDR
7 immune system MP:0005387 10.13 ANGPT2 EMP2 F2 F3 FGR FLT1
8 mortality/aging MP:0010768 10.07 AFP ANGPT2 F2 F3 FLT1 KDR
9 integument MP:0010771 10.01 ANGPT2 F2 F3 KDR LEP PGF
10 muscle MP:0005369 9.87 APLN F3 FLT1 KDR LEP TEK
11 normal MP:0002873 9.76 F2 F3 FGR FLT1 KDR TEK
12 neoplasm MP:0002006 9.73 AFP F3 LEP PGF TH VEGFA
13 respiratory system MP:0005388 9.56 ANGPT2 F2 F3 KDR LEP PGF
14 vision/eye MP:0005391 9.32 ANGPT2 APLN F3 FLT1 KDR LEP
Sources

Drugs & Therapeutics for Placental Insufficiency

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Drugs for Placental Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-78-2 2244
2
tannic acid Approved Phase 4 1401-55-4
3
Enoxaparin Approved Phase 4,Phase 3 9005-49-6 772
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5
Dalteparin Approved Phase 4,Phase 3 9005-49-6
6
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 46507594 772
7
Warfarin Approved Phase 4 81-81-2 54678486 6691
8 Platelet Aggregation Inhibitors Phase 4,Phase 2,Not Applicable
9 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
10 Analgesics Phase 4,Phase 2,Not Applicable
11 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
13 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
14 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
15 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
16 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Antipyretics Phase 4,Phase 2,Not Applicable
18 Anticoagulants Phase 4,Phase 3,Phase 2
19 calcium heparin Phase 4,Phase 3,Phase 2
20 Heparin, Low-Molecular-Weight Phase 4,Phase 3
21
Sodium Citrate Approved, Investigational Phase 3,Phase 2 68-04-2
22
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
23
Calcium Approved, Nutraceutical Phase 3,Phase 2 7440-70-2 271
24
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 77-92-9 311
25 Phosphodiesterase 5 Inhibitors Phase 3,Phase 2
26 Sildenafil Citrate Phase 3,Phase 2 171599-83-0
27 Chelating Agents Phase 3,Phase 2
28 Calcium, Dietary Phase 3,Phase 2
29 Vasodilator Agents Phase 3,Phase 2
30 Phosphodiesterase Inhibitors Phase 3,Phase 2
31 Citrate Phase 3,Phase 2
32
Certolizumab pegol Approved Phase 2 428863-50-7
33 Immunologic Factors Phase 2
34 Immunosuppressive Agents Phase 2
35
Allopurinol Approved Not Applicable 315-30-0 2094
36 Coconut Approved Not Applicable
37
Ondansetron Approved Not Applicable 99614-02-5 4595
38
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
39 Free Radical Scavengers Not Applicable
40 Protective Agents Not Applicable
41 Antimetabolites Not Applicable
42 Antioxidants Not Applicable
43 Fibrin fragment D
44 Anesthetics Not Applicable
45 Pharmaceutical Solutions Not Applicable
46 retinol Not Applicable
47 Retinol palmitate Not Applicable
48 Plasma Substitutes Not Applicable
49 Central Nervous System Depressants Not Applicable
50 Hydroxyethyl Starch Derivatives Not Applicable

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
2 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
3 Timing of Initiation of LMWH Administration in Pregnant Women With APS Completed NCT02326051 Phase 4 Enoxaparin;Enoxaparin
4 Use of Warfarin After the First Trimester in Pregnant Women With APS Recruiting NCT02303171 Phase 4 Enoxaparin;Warfarin
5 Low Weight Heparin prOphylaxis for Placental‐Mediated Complications of PrEgnancy Completed NCT01388322 Phase 3 Enoxaparin
6 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
7 Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment Recruiting NCT03230162 Phase 3 Sildenafil;low molecular weight heparin
8 The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction) Terminated NCT02277132 Phase 2, Phase 3 Sildenafil;Placebo
9 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
10 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
11 IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy Recruiting NCT03152058 Phase 2 Certolizumab Pegol
12 Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss Withdrawn NCT02379650 Phase 2 Hydroxychloroquine (HCQ);Placebo
13 Revealed Versus Concealed Cerebroplacental Ratio Unknown status NCT02907242 Not Applicable
14 Antenatal Allopurinol in Intrauterine Growth Restriction Unknown status NCT00346463 Not Applicable Allopurinol
15 The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies Unknown status NCT01384136
16 Ultrasound Monitoring of Fetuses With Vascular Intra-uterine Growth Restriction (IUGR) Using the Isthmus Systolic Index (ISI): Feasibility, Comparison to Normal Fetuses and Association With Perinatal Mortality Unknown status NCT02813525
17 Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Unknown status NCT00345852 Not Applicable
18 Doppler and Biological Second Trimester Placental Insufficiency Screening Completed NCT00465634
19 Early Placental Insufficiency Screening Completed NCT01348711
20 Free DNA and Nucleosome Concentrations in Pathological Pregnancies Completed NCT01736826
21 Intraumbilical Amino Acids and Glucose Supplementation Via Port by Severe IUGR in Human Fetuses Completed NCT02596594 Not Applicable
22 Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial. Completed NCT01777022 Not Applicable
23 Splanchnic Oxygenation Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler. Completed NCT02971566
24 Observational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy Completed NCT00930397
25 Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors Completed NCT00987701 Not Applicable Ringer's Lactate;Six percent hydroxyethyl starch
26 Renal Artery Dopplers in Twin Twin Transfusion Syndrome Completed NCT03449823
27 Ocular Findings in Women With Primary Antiphospholipid Syndrome Completed NCT03459508
28 Walking and Dietary Modification for Recurrent Early Miscarriages Completed NCT03023137 Not Applicable
29 Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency Recruiting NCT03731611 Not Applicable
30 Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency Recruiting NCT03731546 Not Applicable
31 Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler (MICRODOPPLER PLACENTA) Recruiting NCT03860103
32 PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome Recruiting NCT03100084
33 First Trimester Placental Assessment in the Screening of Preeclampsia and Intrauterine Growth Restriction Recruiting NCT02879942
34 Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight Recruiting NCT03187938
35 Imaging Innovations for Placental Assessment in Response to Environmental Pollution (PARENTs) Recruiting NCT02786420
36 MRI Assessment of Placental Health Recruiting NCT02297724
37 Evaluation of Fetoplacental Oxygenation With Functional MRI in Pregnant Women Recruiting NCT02238301 Not Applicable
38 L-arginine in Treatment of Intrauterine Growth Restriction Recruiting NCT03321292 Not Applicable L-arginine 1000 mg and Acetylesalicylic acid75mg;acetylsalicylic acid 75 mg
39 Assessment of Cardiac Sparing in Fetal Hypoxia Recruiting NCT03146507
40 Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) Recruiting NCT00198068
41 Placenta Imaging Project Recruiting NCT02749851
42 Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE Active, not recruiting NCT01092949

Search NIH Clinical Center for Placental Insufficiency

Cochrane evidence based reviews: placental insufficiency

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Genetic Tests for Placental Insufficiency

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Anatomical Context for Placental Insufficiency

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MalaCards organs/tissues related to Placental Insufficiency:

42
Placenta, Heart, Brain, Testes, Retina, Skin, Testis
Sources

Publications for Placental Insufficiency

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Articles related to Placental Insufficiency:

(show top 50) (show all 260)
# Title Authors Year
1
Early Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation. ( 30685870 )
2019
2
Maternal Choline Supplementation Modulates Placental Markers of Inflammation, Angiogenesis, and Apoptosis in a Mouse Model of Placental Insufficiency. ( 30759768 )
2019
3
Correction: Revealed versus concealed criteria for placental insufficiency in an unselected obstetric population in late pregnancy (RATIO37): randomised controlled trial study protocol. ( 30782957 )
2019
4
Melatonin decreases and cytokines increase in women with placental insufficiency. ( 31023180 )
2019
5
Novel Detection of Placental Insufficiency by Magnetic Resonance Imaging in the Nonhuman Primate. ( 28330415 )
2018
6
Screening for fetal growth restriction and placental insufficiency. ( 29221766 )
2018
7
Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency. ( 29536649 )
2018
8
Recombinant human soluble thrombomodulin as an anticoagulation therapy improves recurrent miscarriage and fetal growth restriction due to placental insufficiency - The leading cause of preeclampsia. ( 29908636 )
2018
9
Study of mitochondrial function in placental insufficiency. ( 29941168 )
2018
10
Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study. ( 30028257 )
2018
11
Fetal undernutrition, placental insufficiency and pancreatic β-cell development programming in utero. ( 30110175 )
2018
12
Placental insufficiency contributes to fatty acid metabolism alterations in aged female mouse offspring. ( 30207754 )
2018
13
Achieving orphan designation for placental insufficiency: annual incidence estimations in Europe. ( 30576053 )
2018
14
Caspase dependent and independent mechanisms of apoptosis across gestation in a sheep model of placental insufficiency and intrauterine growth restriction. ( 28083721 )
2017
15
Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency. ( 28194805 )
2017
16
Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. ( 28295343 )
2017
17
Enhanced insulin secretion and insulin sensitivity in young lambs with placental insufficiency-induced intrauterine growth restriction. ( 28490449 )
2017
18
Revealed versus concealed criteria for placental insufficiency in an unselected obstetric population in late pregnancy (RATIO37): randomised controlled trial study protocol. ( 28619771 )
2017
19
In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study. ( 28623277 )
2017
20
Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency. ( 28623975 )
2017
21
The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency. ( 28698875 )
2017
22
Maternal Choline Supplementation Alters Fetal Growth Patterns in a Mouse Model of Placental Insufficiency. ( 28718809 )
2017
23
Maternal Obesity and Male Genital Anomalies: Potential Role of Placental Insufficiency and Metabolic Syndrome. ( 28815740 )
2017
24
Livebirth and utero-placental insufficiency in Papio hamadryas baboons with uterus angiosome perfused by bilateral utero-ovarian microsurgical anastomoses alone. ( 28854716 )
2017
25
Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study. ( 28854913 )
2017
26
Effect of Transdermal Nitroglycerine on Doppler Velocity Waveforms of the Uterine, Umbilical and Fetal Middle Cerebral Arteries in Patients with Chronic Placental Insufficiency: A Prospective RCT. ( 28892981 )
2017
27
Effects of transcutaneous electrical nerve stimulation on fetal and placental development in an experimental model of placental insufficiency. ( 25567559 )
2016
28
Low-molecular-weight heparin and placental insufficiency: miracle drug or modern day blood letting? ( 26192695 )
2016
29
Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency. ( 26599800 )
2016
30
MR Imaging of Fetuses to Evaluate Placental Insufficiency. ( 26607809 )
2016
31
Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production. ( 26723529 )
2016
32
Placental Insufficiency in Fetuses That Slow in Growth but Are Born Appropriate for Gestational Age: A Prospective Longitudinal Study. ( 26730589 )
2016
33
Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency. ( 26880769 )
2016
34
Increased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis. ( 26903689 )
2016
35
Impact of placental insufficiency on fetal skeletal muscle growth. ( 26994511 )
2016
36
Placental insufficiency among high-risk pregnancies with a normal umbilical artery resistance index after 32weeks. ( 27515046 )
2016
37
Definitions and reporting of placental insufficiency in biomedical journals: a review of the literature. ( 27591716 )
2016
38
Disease-Modifying Drug Possibly Linked to Placental Insufficiency: Severe placental complications in a pregnant woman with multiple sclerosis. ( 27606121 )
2016
39
Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model. ( 27806942 )
2016
40
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO)--conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. ( 25245499 )
2015
41
Altered amniotic fluid leptin levels in twin-twin transfusion syndrome with concurrent placental insufficiency. ( 25248665 )
2015
42
Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep. ( 25249573 )
2015
43
Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay. ( 25485869 )
2015
44
The 4G/4G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene as an independent risk factor for placental insufficiency, which triggers fetal hemodynamic centralization. ( 25723084 )
2015
45
Computerized fetal heart rate analysis in the prediction of myocardial damage in pregnancies with placental insufficiency. ( 25917436 )
2015
46
Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn rat following placental insufficiency. ( 26014855 )
2015
47
Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies. ( 26030512 )
2015
48
Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies-reply. ( 26030513 )
2015
49
Prevention of Defective Placentation and Pregnancy Loss by Blocking Innate Immune Pathways in a Syngeneic Model of Placental Insufficiency. ( 26071558 )
2015
50
Fetal growth according to different reference ranges in twin pregnancies with placental insufficiency. ( 26735222 )
2015
Sources

Variations for Placental Insufficiency

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Expression for Placental Insufficiency

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Search GEO for disease gene expression data for Placental Insufficiency.
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Pathways for Placental Insufficiency

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Pathways related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 65
Show member pathways
 13.38 ANGPT2 F2 FLT1 KDR PGF PROK1
2
Akt Signaling 65
Show member pathways
 13.26 ANGPT2 FLT1 KDR PGF PROK1 TEK
3
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 13.15 ANGPT2 F2 F3 FGR TEK VEGFA
4
PAK Pathway 65
Show member pathways
 13.13 ANGPT2 FLT1 KDR PGF PROK1 TEK
5
Nanog in Mammalian ESC Pluripotency 65
Show member pathways
 13.11 FLT1 KDR PGF PROK1 TEK VEGFA
6
p70S6K Signaling 65
Show member pathways
 12.9 F2 FLT1 KDR PGF PROK1
7
PI3K-Akt signaling pathway 38
Show member pathways
 12.81 ANGPT2 FLT1 KDR PGF TEK VEGFA
8
Focal Adhesion 1 38
Show member pathways
 12.72 FGR FLT1 KDR PGF VEGFA
9
NF-KappaB Family Pathway 65
Show member pathways
 12.55 FLT1 KDR PGF PROK1
10
TRAF Pathway 65
Show member pathways
 12.48 FLT1 KDR PGF VEGFA
11
MAPK signaling pathway 1 38
12.47 ANGPT2 FLT1 KDR PGF TEK VEGFA
12
Ras signaling pathway 38
Show member pathways
 12.38 ANGPT2 FLT1 KDR PGF TEK VEGFA
13
VEGF Pathway (Qiagen) 65
Show member pathways
 12.25 FLT1 KDR PGF VEGFA
14
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12.24 FLT1 KDR PGF PROK1 TEK
15
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.12 FLT1 KDR PGF PROK1
16
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.93 AFP KDR VEGFA
17
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.92 ANGPT2 FLT1 KDR PGF PROK1
18
EPHA forward signaling 1
Show member pathways
 11.85 FGR KDR VEGFA
19
S1P3 pathway 1
Show member pathways
 11.85 FLT1 KDR VEGFA
20
Tyrosine Kinases / Adaptors 4
11.72 ANGPT2 FGR FLT1 KDR TEK
21
HIF-1 signaling pathway 38
11.71 ANGPT2 FLT1 TEK VEGFA
22
Rheumatoid arthritis 38
11.7 FLT1 TEK VEGFA
23
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.63 FLT1 KDR PGF VEGFA
24
Vemurafenib Pathway, Pharmacodynamics 62
11.33 FLT1 KDR VEGFA
25
Angiogenesis (CST) 4
11.3 ANGPT2 F3 FLT1 KDR TEK
26
HIF-2-alpha transcription factor network 1
11.18 FLT1 KDR VEGFA
27
Glypican 1 network 1
11.05 FGR FLT1 VEGFA
28
Cytoskeleton remodeling_RalB regulation pathway 23
10.96 FLT1 KDR VEGFA
29
G-protein signaling_Rap2B regulation pathway 23
10.81 ANGPT2 FLT1 KDR PGF PROK1 TEK
30
Angiogenesis (WikiPathways) 1
10.3 FLT1 KDR TEK VEGFA
Sources

GO Terms for Placental Insufficiency

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Cellular components related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 AFP ANGPT2 APLN F2 F3 FLT1
2 extracellular region GO:0005576 9.44 AFP ANGPT2 APLN F2 F3 FGR

Biological processes related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.97 APLN F2 LEP PGF PROK1 VEGFA
2 negative regulation of apoptotic process GO:0043066 9.96 KDR LEP TEK VEGFA
3 peptidyl-tyrosine phosphorylation GO:0018108 9.94 FGR FLT1 KDR TEK
4 protein autophosphorylation GO:0046777 9.92 FGR FLT1 KDR TEK
5 positive regulation of cell migration GO:0030335 9.91 F3 FGR FLT1 KDR VEGFA
6 positive regulation of cell proliferation GO:0008284 9.91 APLN EMP2 F2 FLT1 KDR LEP
7 regulation of cell shape GO:0008360 9.9 F2 FGR KDR VEGFA
8 positive regulation of protein phosphorylation GO:0001934 9.88 F2 KDR PGF TEK VEGFA
9 response to hypoxia GO:0001666 9.85 ANGPT2 LEP PGF TEK TH VEGFA
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.83 FGR FLT1 KDR TEK
11 positive regulation of endothelial cell migration GO:0010595 9.82 KDR TEK VEGFA
12 positive regulation of cell division GO:0051781 9.81 PGF PROK1 VEGFA
13 positive regulation of endothelial cell proliferation GO:0001938 9.8 F3 KDR PGF TEK VEGFA
14 response to activity GO:0014823 9.79 ANGPT2 LEP TH
15 regulation of angiogenesis GO:0045765 9.77 EMP2 LEP PROK1
16 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.76 FLT1 KDR VEGFA
17 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.76 FLT1 KDR PGF VEGFA
18 positive regulation of MAPK cascade GO:0043410 9.75 FLT1 KDR LEP
19 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.74 FGR FLT1 TEK
20 sprouting angiogenesis GO:0002040 9.73 PGF TEK VEGFA
21 positive regulation of focal adhesion assembly GO:0051894 9.71 KDR TEK VEGFA
22 eating behavior GO:0042755 9.68 LEP TH
23 cell migration involved in sprouting angiogenesis GO:0002042 9.68 KDR VEGFA
24 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 FLT1 VEGFA
25 eye photoreceptor cell development GO:0042462 9.67 TH VEGFA
26 induction of positive chemotaxis GO:0050930 9.67 PGF VEGFA
27 sexual reproduction GO:0019953 9.67 AFP LEP
28 ovulation from ovarian follicle GO:0001542 9.66 AFP LEP
29 positive regulation of mast cell chemotaxis GO:0060754 9.65 PGF VEGFA
30 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 KDR VEGFA
31 glomerulus vasculature development GO:0072012 9.63 ANGPT2 TEK
32 negative regulation of vasoconstriction GO:0045906 9.63 APLN LEP
33 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 F2 FGR FLT1 KDR LEP TEK
34 vascular endothelial growth factor signaling pathway GO:0038084 9.62 FLT1 KDR PGF VEGFA
35 Tie signaling pathway GO:0048014 9.61 ANGPT2 TEK
36 positive regulation of positive chemotaxis GO:0050927 9.61 F3 KDR VEGFA
37 positive regulation of angiogenesis GO:0045766 9.5 ANGPT2 F3 FLT1 KDR PGF TEK
38 angiogenesis GO:0001525 9.28 ANGPT2 APLN FLT1 KDR LEP PGF
39 multicellular organism development GO:0007275 10.16 ANGPT2 APLN F2 FLT1 KDR PGF
40 cell differentiation GO:0030154 10.02 ANGPT2 FGR FLT1 KDR PGF VEGFA

Molecular functions related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 ANGPT2 APLN F2 FGR LEP
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 FLT1 KDR TEK
3 growth factor binding GO:0019838 9.43 FLT1 KDR TEK
4 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 FLT1 KDR
5 growth factor activity GO:0008083 9.26 F2 PGF PROK1 VEGFA
6 protein tyrosine kinase activity GO:0004713 8.92 FGR FLT1 KDR TEK
Sources

Sources for Placental Insufficiency

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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