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MCID: PLC005
MIFTS: 59

Placental Insufficiency

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Placental Insufficiency

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MalaCards integrated aliases for Placental Insufficiency:

Name: Placental Insufficiency 12 59 55 44 15 73
Uteroplacental Vascular Insufficiency 59

Characteristics:

Orphanet epidemiological data:

59
placental insufficiency
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Reproductive diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare gynaecological and obstetric diseases


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Summaries for Placental Insufficiency

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Disease Ontology : 12 A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

MalaCards based summary : Placental Insufficiency, also known as uteroplacental vascular insufficiency, is related to eclampsia and severe pre-eclampsia. An important gene associated with Placental Insufficiency is PGF (Placental Growth Factor), and among its related pathways/superpathways are Akt Signaling and TGF-Beta Pathway. The drugs Aspirin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and lung, and related phenotypes are autism and intrauterine growth retardation

Wikipedia : 76 Placental insufficiency or utero-placental insufficiency is the failure of the placenta to deliver... more...

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Related Diseases for Placental Insufficiency

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Diseases related to Placental Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 eclampsia 30.4 F2 FLT1 PGF
2 severe pre-eclampsia 29.9 FGR LEP PGF VEGFA
3 hellp syndrome 29.3 F2 F3 FLT1 PGF
4 pre-eclampsia 29.2 AFP F2 F3 FLT1 KDR LEP
5 cholestasis, intrahepatic, of pregnancy, 1 11.1
6 cholestasis, intrahepatic, of pregnancy 3 11.1
7 glomeruloid hemangioma 10.3 FLT1 VEGFA
8 microcystic meningioma 10.2 FLT1 VEGFA
9 sick building syndrome 10.2 LEP VEGFA
10 hematocele of tunica vaginalis testis 10.2 AFP ANGPT2
11 neovascular glaucoma 10.2 PGF VEGFA
12 critical limb ischemia 10.2 TEK VEGFA
13 patau syndrome 10.2 AFP PGF
14 kuhnt-junius degeneration 10.2 PGF VEGFA
15 cancer-associated retinopathy 10.2 FLT1 PGF VEGFA
16 mild pre-eclampsia 10.2 FLT1 LEP PGF
17 chronic myocardial ischemia 10.2 TEK VEGFA
18 angiodysplasia 10.2 ANGPT2 VEGFA
19 twin-to-twin transfusion syndrome 10.2 ANGPT2 FLT1 PGF
20 lipodermatosclerosis 10.2 ANGPT2 FLT1 VEGFA
21 background diabetic retinopathy 10.2 ANGPT2 VEGFA
22 endometrial small cell carcinoma 10.2 AFP F2
23 ischemic colitis 10.2 F2 VEGFA
24 microvascular complications of diabetes 1 10.2 ANGPT2 FLT1 VEGFA
25 ovarian cyst 10.1 AFP VEGFA
26 vitamin k deficiency hemorrhagic disease 10.1 AFP F2
27 hypoxia 10.1
28 pyogenic granuloma 10.1 ANGPT2 TEK VEGFA
29 placental abruption 10.1 F2 FLT1 PGF
30 retinal vascular occlusion 10.1 F2 PGF VEGFA
31 peliosis hepatis 10.1 AFP F2 VEGFA
32 intermittent claudication 10.1 ANGPT2 F2 VEGFA
33 gastrointestinal system disease 10.1 AFP F2 VEGFA
34 radiation proctitis 10.1 KDR VEGFA
35 angiokeratoma circumscriptum 10.1 FLT1 KDR VEGFA
36 skin hemangioma 10.1 FLT1 KDR VEGFA
37 placenta accreta 10.0 ANGPT2 FLT1 PGF TEK
38 vascular cancer 10.0 FLT1 KDR VEGFA
39 epileptic encephalopathy, childhood-onset 10.0 ANGPT2 KDR VEGFA
40 bladder neck obstruction 10.0 AFP F3
41 autism 10.0
42 cerebral falx meningioma 10.0 F2 F3
43 leech infestation 10.0 F2 F3
44 prothrombin deficiency 10.0 F2 F3
45 epithelioid hemangioendothelioma 10.0 FLT1 KDR PGF VEGFA
46 intestinal impaction 10.0 F2 F3
47 fournier gangrene 10.0 F2 F3
48 cerebral sinovenous thrombosis 10.0 F2 F3
49 retinal vascular disease 10.0 FLT1 KDR PGF VEGFA
50 qualitative platelet defect 10.0 F2 F3

Graphical network of the top 20 diseases related to Placental Insufficiency:



Diseases related to Placental Insufficiency
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Symptoms & Phenotypes for Placental Insufficiency

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Human phenotypes related to Placental Insufficiency:

59 32 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 autism 59 32 frequent (33%) Frequent (79-30%) HP:0000717
2 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
3 hypoxemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0012418
4 preeclampsia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100602
5 cerebral palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0100021
6 spontaneous abortion 59 32 occasional (7.5%) Occasional (29-5%) HP:0005268
7 neurodevelopmental abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0012759
8 insulin resistance 59 32 occasional (7.5%) Occasional (29-5%) HP:0000855
9 systemic lupus erythematosus 59 32 frequent (33%) Frequent (79-30%) HP:0002725
10 small for gestational age 59 32 hallmark (90%) Very frequent (99-80%) HP:0001518
11 abnormal heart morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0001627
12 small placenta 59 32 hallmark (90%) Very frequent (99-80%) HP:0006266
13 proportionate short stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0003508
14 eclampsia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100601
15 maternal hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0008071
16 antiphospholipid antibody positivity 59 32 frequent (33%) Frequent (79-30%) HP:0003613
17 abnormal umbilical cord blood vessels 59 32 hallmark (90%) Very frequent (99-80%) HP:0011403
18 abnormality of lung morphology 59 Occasional (29-5%)
19 autistic behavior 59 Frequent (79-30%)
20 abnormality of the placenta 59 Obligate (100%)
21 abnormal lung morphology 32 occasional (7.5%) HP:0002088

GenomeRNAi Phenotypes related to Placental Insufficiency according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.8 FGR FLT1 TEK

MGI Mouse Phenotypes related to Placental Insufficiency:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 ANGPT2 EMP2 F2 F3 FGR FLT1
2 homeostasis/metabolism MP:0005376 10.23 AFP ANGPT2 F2 F3 FLT1 KDR
3 embryo MP:0005380 10.21 EMP2 F2 F3 FLT1 KDR LEP
4 behavior/neurological MP:0005386 10.19 AFP F2 F3 FLT1 KDR LEP
5 growth/size/body region MP:0005378 10.19 F2 F3 FLT1 KDR LEP PGF
6 hematopoietic system MP:0005397 10.18 EMP2 F2 F3 FGR FLT1 KDR
7 immune system MP:0005387 10.17 ANGPT2 EMP2 F2 F3 FGR FLT1
8 integument MP:0010771 10.06 ANGPT2 F2 F3 KDR LEP PGF
9 mortality/aging MP:0010768 10.06 AFP ANGPT2 F2 F3 FLT1 KDR
10 liver/biliary system MP:0005370 9.85 AFP KDR LEP SOCS3 TH VEGFA
11 normal MP:0002873 9.81 F2 F3 FGR FLT1 KDR SOCS3
12 neoplasm MP:0002006 9.73 AFP F3 LEP PGF TH VEGFA
13 respiratory system MP:0005388 9.61 ANGPT2 F2 F3 KDR LEP PGF
14 vision/eye MP:0005391 9.28 ANGPT2 F3 FLT1 KDR LEP PGF
Sources

Drugs & Therapeutics for Placental Insufficiency

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Drugs for Placental Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-78-2 2244
2
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
3
Enoxaparin Approved Phase 4,Phase 3 9005-49-6 772
4 tannic acid Approved Phase 4
5
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
6
Dalteparin Approved Phase 4,Phase 3 9005-49-6
7
Warfarin Approved Phase 4 81-81-2 6691 54678486
8 Analgesics Phase 4,Phase 2,Not Applicable
9 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
11 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
12 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
13 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
14 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
15 Platelet Aggregation Inhibitors Phase 4,Phase 2,Not Applicable
16 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Antipyretics Phase 4,Phase 2,Not Applicable
18 Anticoagulants Phase 4,Phase 3,Phase 2
19 calcium heparin Phase 4,Phase 3,Phase 2
20 Heparin, Low-Molecular-Weight Phase 4,Phase 3
21
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
22
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 77-92-9 311
23 Chelating Agents Phase 3,Phase 2
24 Calcium, Dietary Phase 3,Phase 2
25 Sildenafil Citrate Phase 3,Phase 2 171599-83-0
26 Phosphodiesterase Inhibitors Phase 3,Phase 2
27 Citrate Phase 3,Phase 2
28 Vasodilator Agents Phase 3,Phase 2
29 Phosphodiesterase 5 Inhibitors Phase 3,Phase 2
30
Certolizumab pegol Approved Phase 2 428863-50-7
31 Immunosuppressive Agents Phase 2
32 Immunologic Factors Phase 2
33
Allopurinol Approved Not Applicable 315-30-0 2094
34 Coconut Approved Not Applicable
35
Ondansetron Approved Not Applicable 99614-02-5 4595
36
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
37 Antimetabolites Not Applicable
38 Antioxidants Not Applicable
39 Free Radical Scavengers Not Applicable
40 Protective Agents Not Applicable
41 Fibrin fragment D
42 Retinol palmitate Not Applicable
43 retinol Not Applicable
44 Pharmaceutical Solutions Not Applicable
45 Anesthetics Not Applicable
46 Plasma Substitutes Not Applicable
47 Blood Substitutes Not Applicable
48 Hydroxyethyl Starch Derivatives Not Applicable
49 Central Nervous System Depressants Not Applicable
50 Antibodies

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
2 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
3 Timing of Initiation of LMWH Administration in Pregnant Women With APS Completed NCT02326051 Phase 4 Enoxaparin;Enoxaparin
4 Use of Warfarin After the First Trimester in Pregnant Women With APS Recruiting NCT02303171 Phase 4 Enoxaparin;Warfarin
5 Low Weight Heparin prOphylaxis for Placental‐Mediated Complications of PrEgnancy Completed NCT01388322 Phase 3 Enoxaparin
6 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
7 Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment Recruiting NCT03230162 Phase 3 Sildenafil;low molecular weight heparin
8 The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction) Terminated NCT02277132 Phase 2, Phase 3 Sildenafil;Placebo
9 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
10 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
11 IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy Recruiting NCT03152058 Phase 2 Certolizumab Pegol
12 Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss Withdrawn NCT02379650 Phase 2 Hydroxychloroquine (HCQ);Placebo
13 Revealed Versus Concealed Cerebroplacental Ratio Unknown status NCT02907242 Not Applicable
14 Antenatal Allopurinol in Intrauterine Growth Restriction Unknown status NCT00346463 Not Applicable Allopurinol
15 The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies Unknown status NCT01384136
16 Ultrasound Monitoring of Fetuses With Vascular Intra-uterine Growth Restriction (IUGR) Using the Isthmus Systolic Index (ISI): Feasibility, Comparison to Normal Fetuses and Association With Perinatal Mortality Unknown status NCT02813525
17 Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Unknown status NCT00345852 Not Applicable
18 Doppler and Biological Second Trimester Placental Insufficiency Screening Completed NCT00465634
19 Early Placental Insufficiency Screening Completed NCT01348711
20 Free DNA and Nucleosome Concentrations in Pathological Pregnancies Completed NCT01736826
21 Intraumbilical Amino Acids and Glucose Supplementation Via Port by Severe IUGR in Human Fetuses Completed NCT02596594 Not Applicable
22 Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial. Completed NCT01777022 Not Applicable
23 Splanchnic Oxygenation Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler. Completed NCT02971566
24 Observational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy Completed NCT00930397
25 Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors Completed NCT00987701 Not Applicable Ringer's Lactate;Six percent hydroxyethyl starch
26 Renal Artery Dopplers in Twin Twin Transfusion Syndrome Completed NCT03449823
27 Ocular Findings in Women With Primary Antiphospholipid Syndrome Completed NCT03459508
28 Walking and Dietary Modification for Recurrent Early Miscarriages Completed NCT03023137 Not Applicable
29 Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency Recruiting NCT03731611 Not Applicable
30 Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency Recruiting NCT03731546 Not Applicable
31 PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome Recruiting NCT03100084
32 First Trimester Placental Assessment in the Screening of Preeclampsia and Intrauterine Growth Restriction Recruiting NCT02879942
33 Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight Recruiting NCT03187938
34 Imaging Innovations for Placental Assessment in Response to Environmental Pollution (PARENTs) Recruiting NCT02786420
35 MRI Assessment of Placental Health Recruiting NCT02297724
36 Evaluation of Fetoplacental Oxygenation With Functional MRI in Pregnant Women Recruiting NCT02238301 Not Applicable
37 L-arginine in Treatment of Intrauterine Growth Restriction Recruiting NCT03321292 Not Applicable L-arginine 1000 mg and Acetylesalicylic acid75mg;acetylsalicylic acid 75 mg
38 Assessment of Cardiac Sparing in Fetal Hypoxia Recruiting NCT03146507
39 Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) Recruiting NCT00198068
40 Placenta Imaging Project Recruiting NCT02749851
41 Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE Active, not recruiting NCT01092949

Search NIH Clinical Center for Placental Insufficiency

Cochrane evidence based reviews: placental insufficiency

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Genetic Tests for Placental Insufficiency

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Anatomical Context for Placental Insufficiency

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MalaCards organs/tissues related to Placental Insufficiency:

41
Placenta, Heart, Lung, Testes, Brain, Liver, Testis
Sources

Publications for Placental Insufficiency

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Articles related to Placental Insufficiency:

(show top 50) (show all 257)
# Title Authors Year
1
Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency. ( 29536649 )
2018
2
Recombinant human soluble thrombomodulin as an anticoagulation therapy improves recurrent miscarriage and fetal growth restriction due to placental insufficiency - The leading cause of preeclampsia. ( 29908636 )
2018
3
Study of mitochondrial function in placental insufficiency. ( 29941168 )
2018
4
Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study. ( 30028257 )
2018
5
Fetal undernutrition, placental insufficiency and pancreatic β-cell development programming in utero. ( 30110175 )
2018
6
Placental insufficiency contributes to fatty acid metabolism alterations in aged female mouse offspring. ( 30207754 )
2018
7
Caspase dependent and independent mechanisms of apoptosis across gestation in a sheep model of placental insufficiency and intrauterine growth restriction. ( 28083721 )
2017
8
Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study. ( 28854913 )
2017
9
Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency. ( 28623975 )
2017
10
Maternal Choline Supplementation Alters Fetal Growth Patterns in a Mouse Model of Placental Insufficiency. ( 28718809 )
2017
11
Revealed versus concealed criteria for placental insufficiency in an unselected obstetric population in late pregnancy (RATIO37): randomised controlled trial study protocol. ( 28619771 )
2017
12
In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study. ( 28623277 )
2017
13
Maternal Obesity and Male Genital Anomalies: Potential Role of Placental Insufficiency and Metabolic Syndrome. ( 28815740 )
2017
14
Effect of Transdermal Nitroglycerine on Doppler Velocity Waveforms of the Uterine, Umbilical and Fetal Middle Cerebral Arteries in Patients with Chronic Placental Insufficiency: A Prospective RCT. ( 28892981 )
2017
15
The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-I^ in Pregnancy Complicated by Placental Insufficiency. ( 28698875 )
2017
16
Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency. ( 28194805 )
2017
17
Livebirth and utero-placental insufficiency in Papio hamadryas baboons with uterus angiosome perfused by bilateral utero-ovarian microsurgical anastomoses alone. ( 28854716 )
2017
18
Novel Detection of Placental Insufficiency by Magnetic Resonance Imaging in the Nonhuman Primate. ( 28330415 )
2017
19
Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. ( 28295343 )
2017
20
Screening for fetal growth restriction and placental insufficiency. ( 29221766 )
2017
21
Enhanced insulin secretion and insulin sensitivity in young lambs with placental insufficiency-induced intrauterine growth restriction. ( 28490449 )
2017
22
Impact of placental insufficiency on fetal skeletal muscle growth. ( 26994511 )
2016
23
Placental insufficiency among high-risk pregnancies with a normal umbilical artery resistance index after 32weeks. ( 27515046 )
2016
24
MR Imaging of Fetuses to Evaluate Placental Insufficiency. ( 26607809 )
2016
25
Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model. ( 27806942 )
2016
26
Disease-Modifying Drug Possibly Linked to Placental Insufficiency: Severe placental complications in a pregnant woman with multiple sclerosis. ( 27606121 )
2016
27
Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency. ( 26880769 )
2016
28
Placental Insufficiency in Fetuses That Slow in Growth but Are Born Appropriate for Gestational Age: A Prospective Longitudinal Study. ( 26730589 )
2016
29
Increased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis. ( 26903689 )
2016
30
Longitudinal maternal haemodynamics in fetal growth restriction in pregnancies at high risk for placental insufficiency. ( 27854379 )
2016
31
Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency. ( 26599800 )
2016
32
Maternal Calorie Restriction Causing Utero-placental Insufficiency Differentially Affects Mammalian Placental Glucose and Leucine Transport Molecular Mechanisms. ( 27494059 )
2016
33
Definitions and reporting of placental insufficiency in biomedical journals: a review of the literature. ( 27591716 )
2016
34
Fetal growth according to different reference ranges in twin pregnancies with placental insufficiency. ( 26735222 )
2015
35
Computerized fetal heart rate analysis in the prediction of myocardial damage in pregnancies with placental insufficiency. ( 25917436 )
2015
36
Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay. ( 25485869 )
2015
37
Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production. ( 26723529 )
2015
38
Effects of transcutaneous electrical nerve stimulation on fetal and placental development in an experimental model of placental insufficiency. ( 25567559 )
2015
39
Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies-reply. ( 26030513 )
2015
40
Prevention of Defective Placentation and Pregnancy Loss by Blocking Innate Immune Pathways in a Syngeneic Model of Placental Insufficiency. ( 26071558 )
2015
41
Low-molecular-weight heparin and placental insufficiency: miracle drug or modern day blood letting? ( 26192695 )
2015
42
The 4G/4G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene as an independent risk factor for placental insufficiency, which triggers fetal hemodynamic centralization. ( 25723084 )
2015
43
Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies. ( 26030512 )
2015
44
[92-OR]: Placental growth factor measurement as a marker of subsequent disease and harm in placental insufficiency conditions. ( 25787444 )
2015
45
Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn rat following placental insufficiency. ( 26014855 )
2015
46
Altered amniotic fluid leptin levels in twin-twin transfusion syndrome with concurrent placental insufficiency. ( 25248665 )
2014
47
Hyperreactio luteinalis: timely diagnosis minimizes the risk of oophorectomy and alerts clinicians to the associated risk of placental insufficiency. ( 24630301 )
2014
48
Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep. ( 25249573 )
2014
49
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. ( 25245499 )
2014
50
Placental findings in late-onset SGA births without Doppler signs of placental insufficiency. ( 24138874 )
2013
Sources

Variations for Placental Insufficiency

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Expression for Placental Insufficiency

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Search GEO for disease gene expression data for Placental Insufficiency.
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Pathways for Placental Insufficiency

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Pathways related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 64
Show member pathways
 13.28 ANGPT2 FLT1 KDR PGF PROK1 TEK
2
TGF-Beta Pathway 64
Show member pathways
 13.26 ANGPT2 F2 FLT1 KDR PGF PROK1
3
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 13.18 ANGPT2 F2 F3 FGR TEK VEGFA
4
PAK Pathway 64
Show member pathways
 13.16 ANGPT2 FLT1 KDR PGF PROK1 TEK
5
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 13.13 FLT1 KDR PGF PROK1 TEK VEGFA
6
p70S6K Signaling 64
Show member pathways
 12.92 F2 FLT1 KDR PGF PROK1
7
PI3K-Akt signaling pathway 37
Show member pathways
 12.87 ANGPT2 FLT1 KDR PGF TEK VEGFA
8
Focal Adhesion 1 37
Show member pathways
 12.76 FGR FLT1 KDR PGF VEGFA
9
NF-KappaB Family Pathway 64
Show member pathways
 12.58 FLT1 KDR PGF PROK1
10
MAPK signaling pathway 37 1
12.55 ANGPT2 FLT1 KDR PGF TEK VEGFA
11
TRAF Pathway 64
Show member pathways
 12.5 FLT1 KDR PGF VEGFA
12
Immune response IL-23 signaling pathway 22
Show member pathways
 12.46 ANGPT2 F2 SOCS3 TEK
13
Ras signaling pathway 37
Show member pathways
 12.44 ANGPT2 FLT1 KDR PGF TEK VEGFA
14
VEGF Pathway (Qiagen) 22
Show member pathways
 12.29 FLT1 KDR PGF VEGFA
15
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.28 FLT1 KDR PGF PROK1 TEK
16
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.14 FLT1 KDR PGF PROK1 SOCS3
17
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.97 ANGPT2 FLT1 KDR PGF PROK1
18
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.95 AFP KDR VEGFA
19
EPHA forward signaling 1
Show member pathways
 11.87 FGR KDR VEGFA
20
S1P3 pathway 1
Show member pathways
 11.87 FLT1 KDR VEGFA
21
HIF-1 signaling pathway 37
11.76 ANGPT2 FLT1 TEK VEGFA
22
Rheumatoid arthritis 37
11.73 FLT1 TEK VEGFA
23
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.7 FLT1 KDR PGF VEGFA
24
Angiogenesis (CST) 4
11.6 ANGPT2 F3 FLT1 KDR TEK
25
Signaling events mediated by PTP1B 1
11.45 FGR LEP SOCS3
26
Vemurafenib Pathway, Pharmacodynamics 61
11.37 FLT1 KDR VEGFA
27
Tyrosine Kinases / Adaptors 4
11.27 ANGPT2 FGR FLT1 KDR SOCS3 TEK
28
HIF-2-alpha transcription factor network 1
11.23 FLT1 KDR VEGFA
29
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 11.16 LEP SOCS3 VEGFA
30
Glypican 1 network 1
11.09 FGR FLT1 VEGFA
31
Cytoskeleton remodeling_RalB regulation pathway 22
10.98 FLT1 KDR VEGFA
32
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.93 SOCS3 VEGFA
33
G-protein signaling_Rap2B regulation pathway 22
10.86 ANGPT2 FLT1 KDR PGF PROK1 TEK
34
Angiogenesis (WikiPathways) 1
10.84 FLT1 KDR TEK VEGFA
35
VEGF binds to VEGFR leading to receptor dimerization 66
Show member pathways
 10.46 FLT1 KDR PGF VEGFA
Sources

GO Terms for Placental Insufficiency

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Cellular components related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AFP ANGPT2 F2 F3 FLT1 LEP
2 extracellular region GO:0005576 9.4 AFP ANGPT2 F2 F3 FGR FLT1

Biological processes related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.94 FGR FLT1 KDR TEK
2 protein autophosphorylation GO:0046777 9.92 FGR FLT1 KDR TEK
3 positive regulation of cell proliferation GO:0008284 9.92 EMP2 F2 FLT1 KDR LEP PGF
4 regulation of cell shape GO:0008360 9.91 F2 FGR KDR VEGFA
5 positive regulation of cell migration GO:0030335 9.89 F3 FGR FLT1 KDR VEGFA
6 positive regulation of MAPK cascade GO:0043410 9.88 FLT1 KDR LEP TEK
7 positive regulation of protein phosphorylation GO:0001934 9.88 F2 KDR PGF TEK VEGFA
8 negative regulation of signal transduction GO:0009968 9.86 FLT1 KDR SOCS3 TEK
9 response to hypoxia GO:0001666 9.85 ANGPT2 LEP PGF TEK TH VEGFA
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 LEP SOCS3 VEGFA
11 positive regulation of endothelial cell migration GO:0010595 9.82 KDR TEK VEGFA
12 positive regulation of cell division GO:0051781 9.81 PGF PROK1 VEGFA
13 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.81 FGR FLT1 KDR TEK
14 positive regulation of endothelial cell proliferation GO:0001938 9.8 F3 KDR PGF TEK VEGFA
15 response to activity GO:0014823 9.79 ANGPT2 LEP TH
16 regulation of angiogenesis GO:0045765 9.77 EMP2 LEP PROK1
17 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.77 FLT1 KDR VEGFA
18 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.76 FLT1 KDR PGF VEGFA
19 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.75 FGR FLT1 TEK
20 sprouting angiogenesis GO:0002040 9.74 PGF TEK VEGFA
21 positive regulation of focal adhesion assembly GO:0051894 9.7 KDR TEK VEGFA
22 eating behavior GO:0042755 9.68 LEP TH
23 cell migration involved in sprouting angiogenesis GO:0002042 9.68 KDR VEGFA
24 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 FLT1 VEGFA
25 eye photoreceptor cell development GO:0042462 9.68 TH VEGFA
26 induction of positive chemotaxis GO:0050930 9.67 PGF VEGFA
27 sexual reproduction GO:0019953 9.67 AFP LEP
28 ovulation from ovarian follicle GO:0001542 9.66 AFP LEP
29 positive regulation of mast cell chemotaxis GO:0060754 9.65 PGF VEGFA
30 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 KDR VEGFA
31 glomerulus vasculature development GO:0072012 9.63 ANGPT2 TEK
32 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 F2 FGR FLT1 KDR LEP TEK
33 Tie signaling pathway GO:0048014 9.61 ANGPT2 TEK
34 positive regulation of positive chemotaxis GO:0050927 9.61 F3 KDR VEGFA
35 vascular endothelial growth factor signaling pathway GO:0038084 9.56 FLT1 KDR PGF VEGFA
36 positive regulation of angiogenesis GO:0045766 9.5 ANGPT2 F3 FLT1 KDR PGF TEK
37 angiogenesis GO:0001525 9.23 ANGPT2 FLT1 KDR LEP PGF PROK1
38 multicellular organism development GO:0007275 10.15 ANGPT2 F2 FLT1 KDR PGF VEGFA
39 cell differentiation GO:0030154 10.08 ANGPT2 FGR FLT1 KDR PGF TEK
40 regulation of signaling receptor activity GO:0010469 10.05 F2 LEP PGF PROK1 VEGFA
41 negative regulation of apoptotic process GO:0043066 10.02 FLT1 KDR LEP SOCS3 TEK VEGFA

Molecular functions related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.71 ANGPT2 F2 FGR LEP
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 FLT1 KDR TEK
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 FLT1 KDR
4 growth factor binding GO:0019838 9.33 FLT1 KDR TEK
5 vascular endothelial growth factor receptor 3 binding GO:0043185 9.26 PGF VEGFA
6 growth factor activity GO:0008083 9.26 F2 PGF PROK1 VEGFA
7 protein tyrosine kinase activity GO:0004713 8.92 FGR FLT1 KDR TEK
Sources

Sources for Placental Insufficiency

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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