MCID: PLC005
MIFTS: 56

Placental Insufficiency

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Placental Insufficiency

MalaCards integrated aliases for Placental Insufficiency:

Name: Placental Insufficiency 12 58 54 44 15 17 71
Uteroplacental Vascular Insufficiency 58

Characteristics:

Orphanet epidemiological data:

58
placental insufficiency
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3891
MeSH 44 D010927
SNOMED-CT 67 156185006
ICD10 via Orphanet 33 O36.5
UMLS via Orphanet 72 C0032051
Orphanet 58 ORPHA439167
UMLS 71 C0032051

Summaries for Placental Insufficiency

Disease Ontology : 12 A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

MalaCards based summary : Placental Insufficiency, also known as uteroplacental vascular insufficiency, is related to antiphospholipid syndrome and eclampsia. An important gene associated with Placental Insufficiency is PGF (Placental Growth Factor), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Aspirin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and fetal brain, and related phenotypes are intrauterine growth retardation and hypoxemia

Wikipedia : 74 Placental insufficiency or utero-placental insufficiency is the failure of the placenta to deliver... more...

Related Diseases for Placental Insufficiency

Diseases related to Placental Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)
# Related Disease Score Top Affiliating Genes
1 antiphospholipid syndrome 31.9 SERPINE1 SERPINC1 F3 F2
2 eclampsia 30.9 VEGFA SERPINC1 PGF PAPPA FLT1 F2
3 severe pre-eclampsia 30.6 VEGFA SERPINC1 PGF PAPPA LEP HIF1A
4 funisitis 30.6 IL6 CXCL8 ANGPT1
5 oligohydramnios 30.5 PGF PAPPA AFP
6 triploidy 30.4 PAPPA AFP
7 placenta praevia 30.3 PGF PAPPA F2
8 chorioangioma 30.3 ANGPT1 AFP
9 tricuspid valve insufficiency 30.2 PAPPA F3 F2
10 chorioamnionitis 30.2 VEGFA IL6 FLT1 CXCL8
11 twin-to-twin transfusion syndrome 30.1 PGF PAPPA FLT1 ANGPT2 ANGPT1
12 placental abruption 30.0 SERPINC1 PGF PAPPA FLT1 F2
13 hyperglycemia 30.0 SERPINE1 LEP IL6 HIF1A
14 thrombophilia 30.0 SERPINE1 SERPINC1 F3 F2
15 thrombosis 30.0 SERPINE1 SERPINC1 F3 F2
16 homocysteinemia 30.0 SERPINE1 SERPINC1 F2
17 placenta disease 30.0 VEGFA SERPINC1 PGF PAPPA IL6 FLT1
18 cerebral palsy 29.9 SERPINE1 SERPINC1 LEP IL6 F2 CXCL8
19 pre-eclampsia 29.9 VEGFA SERPINE1 SERPINC1 PGF PAPPA LEP
20 hellp syndrome 29.7 VEGFA SERPINE1 SERPINC1 PGF LEP IL6
21 body mass index quantitative trait locus 11 29.5 VEGFA SOCS3 SERPINE1 LEP IL6 HIF1A
22 vascular disease 29.5 VEGFA SERPINE1 SERPINC1 LEP IL6 FGF2
23 hypertension, essential 28.3 VEGFA TH TEK SERPINE1 SERPINC1 PGF
24 cholestasis, intrahepatic, of pregnancy, 1 11.1
25 cholestasis, intrahepatic, of pregnancy 3 11.1
26 septate uterus 10.5 KDR FLT1
27 intravascular papillary endothelial hyperplasia 10.5 VEGFA HIF1A
28 microcystic meningioma 10.5 VEGFA FLT1
29 angiokeratoma of mibelli 10.5 KDR FLT1
30 cancer-associated retinopathy 10.5 VEGFA PGF FLT1
31 malignant ciliary body melanoma 10.4 KDR FLT1
32 intermediate malignant teratoma 10.4 PAPPA AFP
33 hematocele of tunica vaginalis testis 10.4 F2 AFP
34 achenbach syndrome 10.4 F3 F2
35 thrombotic microangiopathy 10.4 VEGFA F3
36 neonatal anemia 10.4 PGF PAPPA FLT1
37 obesity-hypoventilation syndrome 10.4 LEP IL6
38 peripartum cardiomyopathy 10.4 VEGFA PGF FLT1
39 chromosomal triplication 10.4 PAPPA AFP
40 glomeruloid hemangioma 10.4 VEGFA IL6 FLT1
41 osteosclerotic myeloma 10.4 VEGFA IL6
42 acute mountain sickness 10.4 VEGFA HIF1A FLT1
43 renal pelvis squamous cell carcinoma 10.4 F3 F2
44 sudden sensorineural hearing loss 10.4 IL6 F2
45 patau syndrome 10.4 PGF PAPPA AFP
46 gestational trophoblastic neoplasm 10.4 PGF PAPPA AFP
47 primary cutaneous b-cell lymphoma 10.4 VEGFA KDR FLT1
48 synovial angioma 10.4 F3 F2
49 femoral neuropathy 10.4 F3 F2
50 lung non-squamous non-small cell carcinoma 10.4 VEGFA KDR FLT1

Graphical network of the top 20 diseases related to Placental Insufficiency:



Diseases related to Placental Insufficiency

Symptoms & Phenotypes for Placental Insufficiency

Human phenotypes related to Placental Insufficiency:

58 31 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001511
2 hypoxemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012418
3 small for gestational age 58 31 hallmark (90%) Very frequent (99-80%) HP:0001518
4 proportionate short stature 58 31 hallmark (90%) Very frequent (99-80%) HP:0003508
5 small placenta 58 31 hallmark (90%) Very frequent (99-80%) HP:0006266
6 abnormal umbilical cord blood vessels 58 31 hallmark (90%) Very frequent (99-80%) HP:0011403
7 autism 58 31 frequent (33%) Frequent (79-30%) HP:0000717
8 antiphospholipid antibody positivity 58 31 frequent (33%) Frequent (79-30%) HP:0003613
9 systemic lupus erythematosus 58 31 frequent (33%) Frequent (79-30%) HP:0002725
10 neurodevelopmental abnormality 58 31 frequent (33%) Frequent (79-30%) HP:0012759
11 abnormal lung morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002088
12 cerebral palsy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100021
13 abnormal heart morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001627
14 insulin resistance 58 31 occasional (7.5%) Occasional (29-5%) HP:0000855
15 spontaneous abortion 58 31 occasional (7.5%) Occasional (29-5%) HP:0005268
16 preeclampsia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100602
17 eclampsia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100601
18 maternal hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0008071
19 autistic behavior 58 Frequent (79-30%)
20 abnormality of the placenta 58 Obligate (100%)

GenomeRNAi Phenotypes related to Placental Insufficiency according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 PAPPA
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-13 9.44 F3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.44 FLT1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.44 F3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 9.44 PAPPA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.44 FLT1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.44 FLT1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.44 PAPPA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.44 FLT1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-32 9.44 PAPPA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.44 PAPPA
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-78 9.44 F3
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-8 9.44 PAPPA

MGI Mouse Phenotypes related to Placental Insufficiency:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.52 ANGPT1 ANGPT2 F2 F3 FGF2 FLT1
2 homeostasis/metabolism MP:0005376 10.49 AFP ANGPT1 ANGPT2 F2 F3 FGF2
3 growth/size/body region MP:0005378 10.44 ANGPT1 F2 F3 FLT1 HIF1A IL6
4 behavior/neurological MP:0005386 10.39 AFP F2 F3 FGF2 FLT1 HIF1A
5 cellular MP:0005384 10.37 ANGPT2 F2 F3 FGF2 FLT1 HIF1A
6 mortality/aging MP:0010768 10.36 AFP ANGPT1 ANGPT2 F2 F3 FGF2
7 hematopoietic system MP:0005397 10.34 ANGPT2 F3 FGF2 FLT1 HIF1A IL6
8 immune system MP:0005387 10.34 ANGPT1 ANGPT2 F2 F3 FLT1 HIF1A
9 embryo MP:0005380 10.33 ANGPT1 F2 F3 FLT1 HIF1A KDR
10 integument MP:0010771 10.29 ANGPT2 F2 F3 HIF1A IL6 KDR
11 muscle MP:0005369 10.18 ANGPT1 F2 F3 FGF2 FLT1 HIF1A
12 liver/biliary system MP:0005370 10.16 AFP HIF1A IL6 KDR LEP SERPINC1
13 nervous system MP:0003631 10.13 ANGPT1 F2 F3 FGF2 FLT1 HIF1A
14 neoplasm MP:0002006 10.07 AFP F3 FGF2 HIF1A IL6 LEP
15 normal MP:0002873 9.96 F2 F3 FLT1 HIF1A KDR PAPPA
16 respiratory system MP:0005388 9.93 ANGPT2 F2 F3 HIF1A IL6 KDR
17 skeleton MP:0005390 9.65 F2 FGF2 HIF1A IL6 KDR LEP
18 vision/eye MP:0005391 9.47 ANGPT1 ANGPT2 F3 FGF2 FLT1 HIF1A

Drugs & Therapeutics for Placental Insufficiency

Drugs for Placental Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
3
tannic acid Approved Phase 4 1401-55-4
4
Enoxaparin Approved Phase 4 9005-49-6 772
5 Analgesics, Non-Narcotic Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Platelet Aggregation Inhibitors Phase 4
9 Fibrinolytic Agents Phase 4
10 Analgesics Phase 4
11 Antirheumatic Agents Phase 4
12 Cyclooxygenase Inhibitors Phase 4
13 Anticoagulants Phase 4
14 Antipyretics Phase 4
15
Heparin Approved, Investigational Phase 3 9005-49-6 772 9812414
16 calcium heparin Phase 3
17 Fibrin fragment D

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Enoxaparine en PREvention Des insuffiSAnces Placentaires Chez Les Femmes eNCEintes Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
2 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
3 Enoxaparin for the Prevention of Placental-Mediated Complications of Pregnancy in Women With Obstetric History or Abnormal Uterine Artery Doppler at First Trimester Ultrasound and Without Thrombophilia: a Multicenter Randomized Controlled Trial Completed NCT01388322 Phase 3 Enoxaparin
4 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
5 Revealed Versus Concealed Criteria for Placental Insufficiency in Unselected Obstetric Population in Late Pregnancy: a Multicenter Randomized Controlled Trial Unknown status NCT02907242
6 Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE Completed NCT01092949
7 Splanchnic Oxygenation and Perfusion Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler: Pattern Assessment and Correlation With Feeding Intolerance Completed NCT02971566
8 Screening for Placental Insufficiency by a Combination of Second Trimester Uterine Artery Doppler and Maternal Serum Leptin and Lipids Completed NCT00465634
9 Placental Insufficiency Screening During First Trimester by a Combination of Uterine Artery Dopppler, Maternal PlGF and sFLT-1 in Hight Risk Population Completed NCT01348711
10 Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency Completed NCT03731546
11 Comparative Study of Plasma Free DNA and Nucleosome Concentrations: Pathological Versus Normal Pregnancies Completed NCT01736826
12 The Evaluation of UTERO - Placental 3D Doppler Examination Potential Interest for Pre- Eclampsia Screening During Pregnancy. Observational Study in 100 Women at High Risk for Pre- Eclampsia and 70 Low Risk Women. Completed NCT00930397
13 Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency Recruiting NCT03731611
14 Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler: an Observational Prospective Study Recruiting NCT03860103
15 The PREPPeD Study: "PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome" Recruiting NCT03100084

Search NIH Clinical Center for Placental Insufficiency

Cochrane evidence based reviews: placental insufficiency

Genetic Tests for Placental Insufficiency

Anatomical Context for Placental Insufficiency

MalaCards organs/tissues related to Placental Insufficiency:

40
Placenta, Endothelial, Fetal Brain, Skeletal Muscle, Heart, Lung, Thyroid

Publications for Placental Insufficiency

Articles related to Placental Insufficiency:

(show top 50) (show all 1862)
# Title Authors PMID Year
1
Reduced maternal serum concentrations of angiopoietin-2 in the first trimester precede intrauterine growth restriction associated with placental insufficiency. 54 61
17949380 2007
2
The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction. 54 61
12740423 2003
3
Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice. 54 61
12163461 2002
4
Placental expression of VEGF, PlGF and their receptors in a model of placental insufficiency-intrauterine growth restriction (PI-IUGR). 61 54
11945079 2002
5
Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. 54 61
11397868 2001
6
Chronic hypoxemia: effects on developing nitrergic and dopaminergic amacrine cells. 54 61
10359329 1999
7
[The importance of determining trophoblastic beta 1-glycoprotein (TBG) for the early diagnosis and prognosis of placental insufficiency in pregnant women with habitual abortion]. 61 54
1814220 1991
8
Hippocampal neurogenesis and memory in adolescence following intrauterine growth restriction. 61
33320965 2021
9
Non-invasive monitoring of pH and oxygen using miniaturized electrochemical sensors in an animal model of acute hypoxia. 61
33541374 2021
10
Treatment of pregnancies complicated by intrauterine growth restriction with nitric oxide donors increases placental expression of Epidermal Growth Factor-Like Domain 7 and improves fetal growth: A pilot study. 61
32784003 2021
11
Intrauterine growth restriction compromises cerebellar development by affecting radial migration of granule cells via the JamC/Pard3a molecular pathway. 61
33259808 2021
12
Case of placental insufficiency and premature delivery in a Fontan pregnancy: physiological insights and considerations on risk stratification. 61
33608474 2021
13
Systematic Reviews and Meta-Analyses Across Species Are Critical to Improve Clinical Translation of Therapeutic Agents for Placental Insufficiency Syndromes. 61
33307851 2021
14
Melatonin decreases and cytokines increase in women with placental insufficiency. 61
31023180 2021
15
Maternal and fetal effects of COVID-19 virus on a complicated triplet pregnancy: a case report. 61
33602315 2021
16
[Uteroplacental blood flow in maternal diabetes mellitus]. 61
33512124 2021
17
Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial. 61
32623628 2021
18
Correlation of maternal body mass index with umbilical artery Doppler in pregnancies complicated by fetal growth restriction and associated outcomes. 61
33420732 2021
19
The placenta as the window to congenital heart disease. 61
33074934 2021
20
Decreasing Insulin Requirements in Pregnancy With Pre-existing or Gestational Diabetes: Management Practices Across Canada. 61
33412304 2021
21
In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat. 61
33389813 2021
22
Oxidative Stress and Neurodevelopmental Outcomes in Rat Offspring with Intrauterine Growth Restriction Induced by Reduced Uterine Perfusion. 61
33435577 2021
23
Genomic imbalances in the placenta are associated with poor fetal growth. 61
33413077 2021
24
Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress. 61
32763717 2021
25
Measurement of Placental Index in Different Gestational Age Groups in Bangladeshi Women. 61
33397865 2021
26
Placental blood flow sensing and regulation in fetal growth restriction. 61
33509641 2021
27
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults. 61
32687731 2021
28
Melatonin 1A and 1B Receptors' Expression Decreases in the Placenta of Women with Fetal Growth Restriction. 61
32804352 2021
29
Right ventricular dysfunction identified by abnormal strain values precedes evident growth restriction in small for gestational age fetuses. 61
32735353 2020
30
A comparison of three classification systems for stillbirth. 61
33307888 2020
31
Deficits in growth, muscle mass, and body composition following placental insufficiency-induced intrauterine growth restriction persisted in lambs at 60 d of age but were improved by daily clenbuterol supplementation. 61
33381721 2020
32
Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight. 61
33357243 2020
33
Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction. 61
33273667 2020
34
Potential effects of transdermal nitric oxide donor on fetal growth restriction and oligohydramnios: A case report. 61
33363920 2020
35
Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism. 61
32926874 2020
36
Maternal Optical Coherence Tomography Angiography Changes Related to Small for Gestational Age Pregnancies. 61
33344048 2020
37
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction. 61
33377492 2020
38
Occupational exposure to pesticides in female tea garden workers and adverse birth outcomes. 61
33350548 2020
39
Fetal heart rate monitoring in labor: from pattern recognition to fetal physiology. 61
33238664 2020
40
Placental vascular tree characterization based on ex-vivo MRI with a potential application for placental insufficiency assessment. 61
32933767 2020
41
Controlled elevated temperatures during early-mid gestation cause placental insufficiency and implications for fetal growth in pregnant pigs. 61
33244103 2020
42
Comments on "Placental vascular tree characterization based on ex-vivo MRI with a potential application for placental insufficiency assessment". 61
33092722 2020
43
Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency. 61
32988220 2020
44
Transcriptomic analysis of equine placenta reveals key regulators and pathways involved in ascending placentitis†. 61
33345276 2020
45
The association between first trimester placental biomarkers and placental lesions of maternal vascular malperfusion. 61
33161363 2020
46
Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction. 61
33256815 2020
47
Cerebroplacental ratio as a predictor of intrapartum fetal compromise in term pregnancy. 61
33258119 2020
48
Evaluation of the human placenta optical scattering properties using continuous wave and frequency-domain diffuse reflectance spectroscopy. 61
33155452 2020
49
Customized birth-weight centiles and placenta-related fetal growth restriction. 61
33073889 2020
50
Hemodynamic findings in normotensive women with small-for-gestational-age and growth-restricted fetuses. 61
33084031 2020

Variations for Placental Insufficiency

Expression for Placental Insufficiency

Search GEO for disease gene expression data for Placental Insufficiency.

Pathways for Placental Insufficiency

Pathways related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.2 VEGFA TEK SOCS3 SERPINE1 PGF LEP
2
Show member pathways
13.86 VEGFA TEK PGF KDR IL6 HIF1A
3
Show member pathways
13.71 TEK SOCS3 LEP KDR IL6 FLT1
4
Show member pathways
13.51 VEGFA TEK SOCS3 PGF KDR IL6
5
Show member pathways
13.45 TEK PGF KDR IL6 FLT1 FGF2
6
Show member pathways
13.38 VEGFA TEK SOCS3 IL6 HIF1A FGF2
7
Show member pathways
13.35 VEGFA TEK SERPINE1 SERPINC1 F3 F2
8
Show member pathways
13.34 TEK PGF KDR IL6 FLT1 FGF2
9
Show member pathways
13.29 VEGFA TEK PGF KDR IL6 FLT1
10
Show member pathways
13.09 PGF KDR IL6 HIF1A FLT1 FGF2
11
Show member pathways
12.97 VEGFA TEK PGF KDR IL6 FLT1
12
Show member pathways
12.96 VEGFA IL6 HIF1A FGF2 CXCL8 ANGPT2
13 12.9 VEGFA PGF IL6 HIF1A FGF2 F2
14 12.78 VEGFA TEK PGF KDR FLT1 FGF2
15
Show member pathways
12.72 PGF KDR IL6 FLT1 FGF2
16
Show member pathways
12.68 VEGFA TEK PGF KDR FLT1 FGF2
17
Show member pathways
12.64 VEGFA KDR IL6 HIF1A FGF2
18
Show member pathways
12.61 TEK SOCS3 IL6 FGF2 F2 ANGPT2
19
Show member pathways
12.44 TEK PGF KDR IL6 FLT1 FGF2
20
Show member pathways
12.4 VEGFA KDR FLT1 FGF2
21 12.4 VEGFA KDR FLT1 FGF2
23 12.32 VEGFA KDR HIF1A FGF2
24
Show member pathways
12.32 VEGFA SOCS3 SERPINE1 HIF1A
25
Show member pathways
12.3 SOCS3 PGF KDR IL6 FLT1 FGF2
26
Show member pathways
12.25 TEK F2 ANGPT2 ANGPT1
27 12.25 VEGFA TH IL6 HIF1A CXCL8
28
Show member pathways
12.18 SERPINE1 SERPINC1 F3 F2
29 12.17 TEK SOCS3 KDR FLT1 FGF2 ANGPT2
30 12.14 SERPINE1 SERPINC1 F3 F2
31 12.13 VEGFA KDR IL6 FGF2 AFP
32 12.12 SOCS3 SERPINE1 LEP IL6 HIF1A
33 11.98 VEGFA SERPINE1 IL6 F3 CXCL8
34 11.94 VEGFA SOCS3 IL6 HIF1A FGF2 CXCL8
35
Show member pathways
11.93 VEGFA PGF KDR HIF1A FLT1
36 11.81 IL6 CXCL8 AFP
37 11.79 VEGFA TH FGF2
38 11.76 VEGFA SERPINE1 LEP HIF1A
39 11.7 VEGFA TEK IL6 FLT1 CXCL8 ANGPT1
40
Show member pathways
11.68 VEGFA IL6 CXCL8
41 11.68 IL6 FGF2 CXCL8
42 11.67 TH SOCS3 IL6 CXCL8
43 11.65 TEK KDR HIF1A FLT1 FGF2 F3
44 11.63 VEGFA IL6 HIF1A CXCL8
45 11.6 VEGFA TEK SERPINE1 IL6 HIF1A FLT1
46 11.56 VEGFA KDR FGF2
47 11.55 VEGFA IL6 FGF2
48 11.53 VEGFA KDR FLT1 FGF2
49 11.52 VEGFA KDR FGF2
50 11.42 VEGFA SERPINE1 KDR FLT1

GO Terms for Placental Insufficiency

Cellular components related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.83 VEGFA SERPINE1 SERPINC1 PGF PAPPA LEP
2 collagen-containing extracellular matrix GO:0062023 9.63 SERPINE1 SERPINC1 F3 F2 ANGPT2 ANGPT1
3 extracellular region GO:0005576 9.55 VEGFA TEK SERPINE1 SERPINC1 PGF PAPPA

Biological processes related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 VEGFA TEK PGF LEP IL6 HIF1A
2 multicellular organism development GO:0007275 10.26 VEGFA TEK PGF KDR FLT1 FGF2
3 cell differentiation GO:0030154 10.23 VEGFA PGF KDR HIF1A FLT1 FGF2
4 positive regulation of cell proliferation GO:0008284 10.15 VEGFA PGF LEP KDR IL6 FLT1
5 positive regulation of gene expression GO:0010628 10.14 VEGFA IL6 HIF1A FGF2 F3 CXCL8
6 negative regulation of apoptotic process GO:0043066 10.11 VEGFA TEK SOCS3 LEP KDR IL6
7 post-translational protein modification GO:0043687 10.09 SOCS3 SERPINC1 IL6 HIF1A AFP
8 negative regulation of gene expression GO:0010629 10.08 VEGFA KDR HIF1A FGF2 CXCL8
9 cellular protein metabolic process GO:0044267 10.04 SERPINC1 PAPPA IL6 F2 AFP
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.04 VEGFA TEK KDR FGF2 ANGPT1
11 positive regulation of protein kinase B signaling GO:0051897 10.03 VEGFA TEK LEP FGF2 F3 ANGPT1
12 leukocyte migration GO:0050900 10.02 TEK F2 ANGPT2 ANGPT1
13 cytokine-mediated signaling pathway GO:0019221 10.02 VEGFA SOCS3 IL6 HIF1A FGF2 F3
14 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.97 TEK KDR FLT1 ANGPT1
15 response to hypoxia GO:0001666 9.95 VEGFA TH TEK PGF LEP HIF1A
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 VEGFA SOCS3 LEP IL6
17 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.92 VEGFA PGF KDR FLT1
18 positive regulation of protein phosphorylation GO:0001934 9.92 VEGFA TEK PGF LEP KDR FGF2
19 positive regulation of MAPK cascade GO:0043410 9.91 VEGFA TEK LEP KDR IL6 FLT1
20 positive regulation of kinase activity GO:0033674 9.9 TEK KDR FLT1
21 response to activity GO:0014823 9.9 TH LEP IL6 ANGPT2
22 positive regulation of MAP kinase activity GO:0043406 9.89 VEGFA FLT1 FGF2
23 positive regulation of interleukin-8 production GO:0032757 9.89 SERPINE1 IL6 F3
24 positive regulation of endothelial cell migration GO:0010595 9.89 VEGFA TEK KDR FGF2 ANGPT1
25 hemostasis GO:0007599 9.88 SERPINC1 F3 F2
26 positive chemotaxis GO:0050918 9.88 VEGFA PGF FGF2 ANGPT1
27 negative regulation of endothelial cell apoptotic process GO:2000352 9.88 TEK SERPINE1 KDR ANGPT1
28 positive regulation of cell division GO:0051781 9.87 VEGFA PGF FGF2
29 lactation GO:0007595 9.87 VEGFA SERPINC1 HIF1A
30 sprouting angiogenesis GO:0002040 9.87 VEGFA TEK PGF ANGPT1
31 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.85 VEGFA KDR FGF2
32 regulation of angiogenesis GO:0045765 9.85 LEP IL6 FGF2
33 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.85 VEGFA KDR FLT1
34 positive regulation of JAK-STAT cascade GO:0046427 9.84 LEP IL6 F2
35 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.84 TEK FLT1 FGF2
36 blood vessel morphogenesis GO:0048514 9.83 HIF1A FLT1 ANGPT2
37 positive regulation of focal adhesion assembly GO:0051894 9.83 VEGFA TEK KDR
38 positive regulation of blood vessel endothelial cell migration GO:0043536 9.83 VEGFA KDR HIF1A FGF2 ANGPT1
39 cell migration involved in sprouting angiogenesis GO:0002042 9.81 VEGFA KDR FGF2
40 induction of positive chemotaxis GO:0050930 9.8 VEGFA PGF CXCL8
41 positive regulation of endothelial cell proliferation GO:0001938 9.8 VEGFA TEK PGF KDR HIF1A FGF2
42 positive regulation of positive chemotaxis GO:0050927 9.79 VEGFA KDR F3
43 vascular endothelial growth factor signaling pathway GO:0038084 9.76 VEGFA PGF KDR FLT1
44 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 VEGFA TEK LEP KDR FLT1 FGF2
45 negative regulation of fibrinolysis GO:0051918 9.73 SERPINE1 F2
46 sexual reproduction GO:0019953 9.73 LEP AFP
47 negative regulation of lipid storage GO:0010888 9.73 LEP IL6
48 regulation of endothelial cell proliferation GO:0001936 9.72 LEP ANGPT1
49 vascular wound healing GO:0061042 9.72 VEGFA KDR
50 hyaloid vascular plexus regression GO:1990384 9.72 TH FLT1

Molecular functions related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 VEGFA TH TEK SOCS3 SERPINE1 SERPINC1
2 signaling receptor binding GO:0005102 9.83 SERPINE1 LEP F2 ANGPT2 ANGPT1
3 cytokine activity GO:0005125 9.78 VEGFA IL6 FGF2 CXCL8
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.58 TEK KDR FLT1
5 growth factor binding GO:0019838 9.5 TEK KDR FLT1
6 vascular endothelial growth factor-activated receptor activity GO:0005021 9.46 KDR FLT1
7 chemoattractant activity GO:0042056 9.43 VEGFA PGF FGF2
8 vascular endothelial growth factor receptor binding GO:0005172 9.37 VEGFA PGF
9 heparin binding GO:0008201 9.35 VEGFA SERPINC1 PGF FGF2 F2
10 growth factor activity GO:0008083 9.02 VEGFA PGF IL6 FGF2 F2

Sources for Placental Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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