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MCID: PLC005
MIFTS: 58

Placental Insufficiency

Categories: Reproductive diseases, Rare diseases, Fetal diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Placental Insufficiency

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MalaCards integrated aliases for Placental Insufficiency:

Name: Placental Insufficiency 12 59 55 44 15 73
Uteroplacental Vascular Insufficiency 59

Characteristics:

Orphanet epidemiological data:

59
placental insufficiency
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Reproductive diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare gynaecological and obstetric diseases


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Summaries for Placental Insufficiency

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Disease Ontology : 12 A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

MalaCards based summary : Placental Insufficiency, also known as uteroplacental vascular insufficiency, is related to eclampsia and placenta disease. An important gene associated with Placental Insufficiency is PGF (Placental Growth Factor), and among its related pathways/superpathways are Akt Signaling and TGF-Beta Pathway. The drugs Aspirin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and lung, and related phenotypes are intrauterine growth retardation and small for gestational age

Wikipedia : 76 Placental insufficiency or utero-placental insufficiency is the failure of the placenta to deliver... more...

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Related Diseases for Placental Insufficiency

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Diseases related to Placental Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 eclampsia 30.6 F2 FLT1 PGF
2 placenta disease 29.8 AFP F3 PGF
3 severe pre-eclampsia 29.6 FGR LEP PGF VEGFA
4 hellp syndrome 28.6 F2 F3 FLT1 PGF
5 pre-eclampsia 26.7 AFP F2 F3 FLT1 KDR LEP
6 cholestasis, intrahepatic, of pregnancy, 1 11.0
7 cholestasis, intrahepatic, of pregnancy 3 11.0
8 glomeruloid hemangioma 10.8 FLT1 VEGFA
9 sick building syndrome 10.7 LEP VEGFA
10 hematocele of tunica vaginalis testis 10.7 AFP ANGPT2
11 neovascular glaucoma 10.7 PGF VEGFA
12 background diabetic retinopathy 10.6 ANGPT2 VEGFA
13 cancer-associated retinopathy 10.6 FLT1 PGF VEGFA
14 mild pre-eclampsia 10.6 FLT1 LEP PGF
15 chronic myocardial ischemia 10.6 TEK VEGFA
16 twin-to-twin transfusion syndrome 10.6 ANGPT2 FLT1 PGF
17 lipodermatosclerosis 10.5 ANGPT2 FLT1 VEGFA
18 microcystic meningioma 10.5 FLT1 VEGFA
19 poems syndrome 10.5 ANGPT2 VEGFA
20 microvascular complications of diabetes 1 10.5 ANGPT2 FLT1 VEGFA
21 endometrial small cell carcinoma 10.5 AFP F2
22 ectopic pregnancy 10.5 PGF PROK1 VEGFA
23 ovarian cyst 10.4 AFP VEGFA
24 vitamin k deficiency hemorrhagic disease 10.4 AFP F2
25 pyogenic granuloma 10.4 ANGPT2 TEK VEGFA
26 placental abruption 10.4 F2 FLT1 PGF
27 retinal vascular occlusion 10.4 F2 PGF VEGFA
28 peliosis hepatis 10.3 AFP F2 VEGFA
29 gastrointestinal system cancer 10.2 AFP F2 VEGFA
30 skin hemangioma 10.2 KDR VEGFA
31 angiokeratoma circumscriptum 10.2 FLT1 KDR VEGFA
32 kuhnt-junius degeneration 10.2 KDR PGF VEGFA
33 radiation proctitis 10.2 KDR VEGFA
34 nonalcoholic steatohepatitis 10.2 F2 LEP
35 placenta accreta 10.2 ANGPT2 FLT1 PGF TEK
36 acute hemorrhagic leukoencephalitis 10.2 FLT1 KDR VEGFA
37 vascular cancer 10.1 FLT1 KDR VEGFA
38 breast carcinoma in situ 10.1 FLT1 KDR VEGFA
39 epileptic encephalopathy, childhood-onset 10.1 ANGPT2 KDR VEGFA
40 hypoxia 10.0
41 capillary hemangioma 10.0 KDR TEK VEGFA
42 cerebritis 10.0
43 epithelioid hemangioendothelioma 9.9 FLT1 KDR PGF VEGFA
44 cerebral falx meningioma 9.9 F2 F3
45 intestinal impaction 9.9 F2 F3
46 fournier gangrene 9.9 F2 F3
47 cerebral sinovenous thrombosis 9.9 F2 F3
48 leech infestation 9.9 F2 F3
49 qualitative platelet defect 9.9 F2 F3
50 giant hemangioma 9.9 F2 F3

Graphical network of the top 20 diseases related to Placental Insufficiency:



Diseases related to Placental Insufficiency
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Symptoms & Phenotypes for Placental Insufficiency

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Human phenotypes related to Placental Insufficiency:

59 32 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
2 small for gestational age 59 32 hallmark (90%) Very frequent (99-80%) HP:0001518
3 proportionate short stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0003508
4 small placenta 59 32 hallmark (90%) Very frequent (99-80%) HP:0006266
5 abnormal umbilical cord blood vessels 59 32 hallmark (90%) Very frequent (99-80%) HP:0011403
6 hypoxemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0012418
7 autism 59 32 frequent (33%) Frequent (79-30%) HP:0000717
8 systemic lupus erythematosus 59 32 frequent (33%) Frequent (79-30%) HP:0002725
9 antiphospholipid antibody positivity 59 32 frequent (33%) Frequent (79-30%) HP:0003613
10 neurodevelopmental abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0012759
11 insulin resistance 59 32 occasional (7.5%) Occasional (29-5%) HP:0000855
12 abnormal heart morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0001627
13 spontaneous abortion 59 32 occasional (7.5%) Occasional (29-5%) HP:0005268
14 maternal hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0008071
15 cerebral palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0100021
16 eclampsia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100601
17 preeclampsia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100602
18 abnormality of the placenta 59 Obligate (100%)
19 autistic behavior 59 Frequent (79-30%)
20 abnormality of lung morphology 59 Occasional (29-5%)
21 abnormal lung morphology 32 occasional (7.5%) HP:0002088

GenomeRNAi Phenotypes related to Placental Insufficiency according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.8 FGR FLT1 TEK

MGI Mouse Phenotypes related to Placental Insufficiency:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 VEGFA ANGPT2 FGR EMP2 FLT1 F2
2 homeostasis/metabolism MP:0005376 10.23 TH VEGFA AFP F3 ANGPT2 FLT1
3 embryo MP:0005380 10.21 VEGFA F3 EMP2 FLT1 F2 KDR
4 behavior/neurological MP:0005386 10.19 TH VEGFA AFP F3 FLT1 F2
5 growth/size/body region MP:0005378 10.19 TH VEGFA F3 FLT1 F2 PGF
6 hematopoietic system MP:0005397 10.18 VEGFA F3 FGR EMP2 FLT1 F2
7 immune system MP:0005387 10.17 VEGFA F3 ANGPT2 FGR EMP2 FLT1
8 integument MP:0010771 10.06 VEGFA TH F3 ANGPT2 F2 KDR
9 mortality/aging MP:0010768 10.06 TH VEGFA AFP F3 ANGPT2 FLT1
10 liver/biliary system MP:0005370 9.85 TH VEGFA AFP KDR SOCS3 LEP
11 normal MP:0002873 9.81 TH VEGFA F3 FGR FLT1 F2
12 neoplasm MP:0002006 9.73 TH VEGFA AFP F3 PGF LEP
13 respiratory system MP:0005388 9.61 VEGFA F3 ANGPT2 F2 KDR SOCS3
14 vision/eye MP:0005391 9.28 VEGFA F3 ANGPT2 FLT1 KDR LEP
Sources

Drugs & Therapeutics for Placental Insufficiency

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Drugs for Placental Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-78-2 2244
2
Dalteparin Approved Phase 4,Phase 3 9005-49-6
3
Enoxaparin Approved Phase 4,Phase 3 9005-49-6 772
4
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
5
Warfarin Approved Phase 4 81-81-2 6691 54678486
6 Analgesics Phase 4,Phase 2,Not Applicable
7 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
8 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
10 Antipyretics Phase 4,Phase 2,Not Applicable
11 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
12 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
13 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
15 Platelet Aggregation Inhibitors Phase 4,Phase 2,Not Applicable
16 Anticoagulants Phase 4,Phase 3,Phase 2
17 calcium heparin Phase 4,Phase 3,Phase 2
18 Heparin, Low-Molecular-Weight Phase 4,Phase 3
19
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
20
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 77-92-9 311
21 Calcium, Dietary Phase 3,Phase 2
22 Chelating Agents Phase 3,Phase 2
23 Phosphodiesterase 5 Inhibitors Phase 3,Phase 2
24 Phosphodiesterase Inhibitors Phase 3,Phase 2
25 Sildenafil Citrate Phase 3,Phase 2 171599-83-0
26 Vasodilator Agents Phase 3,Phase 2
27 Citrate Nutraceutical Phase 3,Phase 2
28
Certolizumab pegol Approved Phase 2 428863-50-7
29 Immunosuppressive Agents Phase 2
30
Allopurinol Approved Not Applicable 315-30-0 2094
31
Ondansetron Approved Not Applicable 99614-02-5 4595
32
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
33 Coconut Approved, Nutraceutical Not Applicable
34 Antimetabolites Not Applicable
35 Antioxidants Not Applicable
36 Protective Agents Not Applicable
37 Anesthetics Not Applicable
38 Pharmaceutical Solutions Not Applicable
39 Retinol palmitate Not Applicable
40 Blood Substitutes Not Applicable
41 Central Nervous System Depressants Not Applicable
42 Hydroxyethyl Starch Derivatives Not Applicable
43 Plasma Substitutes Not Applicable
44 Antiemetics Not Applicable
45 Angiogenesis Inducing Agents
46 Angiogenesis Inhibitors
47 Angiogenesis Modulating Agents
48 Liver Extracts Not Applicable
49 Antibodies
50 Antibodies, Antiphospholipid

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid;Acetylsalicylic Acid
2 Timing of Initiation of LMWH Administration in Pregnant Women With APS Completed NCT02326051 Phase 4 Enoxaparin;Enoxaparin
3 ENOXAPARINE in the Prevention of Placental Insufficiency in Pregnant Women Recruiting NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
4 Use of Warfarin After the First Trimester in Pregnant Women With APS Recruiting NCT02303171 Phase 4 Enoxaparin;Warfarin
5 Low Weight Heparin prOphylaxis for Placental‐Mediated Complications of PrEgnancy Completed NCT01388322 Phase 3 Enoxaparin
6 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
7 Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment Recruiting NCT03230162 Phase 3 Sildenafil;low molecular weight heparin
8 The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction) Recruiting NCT02277132 Phase 2, Phase 3 Sildenafil;Placebo
9 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
10 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
11 IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy Recruiting NCT03152058 Phase 2 Certolizumab Pegol
12 Placenta Imaging Project Recruiting NCT02749851 Phase 1, Phase 2
13 Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss Withdrawn NCT02379650 Phase 2 Hydroxychloroquine (HCQ);Placebo
14 Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE Unknown status NCT01092949
15 Antenatal Allopurinol in Intrauterine Growth Restriction Unknown status NCT00346463 Not Applicable Allopurinol
16 The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies Unknown status NCT01384136
17 Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Unknown status NCT00345852 Not Applicable
18 Doppler and Biological Second Trimester Placental Insufficiency Screening Completed NCT00465634
19 Early Placental Insufficiency Screening Completed NCT01348711
20 Intraumbilical Amino Acids and Glucose Supplementation Via Port by Severe IUGR in Human Fetuses Completed NCT02596594 Not Applicable
21 Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial. Completed NCT01777022 Not Applicable
22 Splanchnic Oxygenation Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler. Completed NCT02971566
23 Observational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy Completed NCT00930397
24 Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors Completed NCT00987701 Not Applicable Ringer's Lactate;Six percent hydroxyethyl starch
25 Walking and Dietary Modification for Recurrent Early Miscarriages Completed NCT03023137 Not Applicable
26 PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome Recruiting NCT03100084
27 First Trimester Placental Assessment in the Screening of Preeclampsia and Intrauterine Growth Restriction Recruiting NCT02879942
28 Revealed Versus Concealed Cerebroplacental Ratio Recruiting NCT02907242 Not Applicable
29 Imaging Innovations for Placental Assessment in Response to Environmental Pollution (PARENTs) Recruiting NCT02786420
30 Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight Recruiting NCT03187938
31 MRI Assessment of Placental Health Recruiting NCT02297724
32 Evaluation of Fetoplacental Oxygenation With Functional MRI in Pregnant Women Recruiting NCT02238301 Not Applicable
33 L-arginine in Treatment of Intrauterine Growth Restriction Recruiting NCT03321292 Not Applicable L-arginine 1000 mg and Acetylesalicylic acid75mg;acetylsalicylic acid 75 mg
34 Assessment of Cardiac Sparing in Fetal Hypoxia Recruiting NCT03146507
35 Ocular Findings in Women With Primary Antiphospholipid Syndrome Recruiting NCT03459508
36 Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) Recruiting NCT00198068
37 Free DNA and Nucleosome Concentrations in Pathological Pregnancies Active, not recruiting NCT01736826
38 Renal Artery Dopplers in Twin Twin Transfusion Syndrome Active, not recruiting NCT03449823
39 Ultrasound Monitoring of Fetuses With Vascular Intra-uterine Growth Restriction (IUGR) Using the Isthmus Systolic Index (ISI): Feasibility, Comparison to Normal Fetuses and Association With Perinatal Mortality Not yet recruiting NCT02813525

Search NIH Clinical Center for Placental Insufficiency

Cochrane evidence based reviews: placental insufficiency

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Genetic Tests for Placental Insufficiency

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Anatomical Context for Placental Insufficiency

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MalaCards organs/tissues related to Placental Insufficiency:

41
Placenta, Heart, Lung, Liver, Brain, Testes, Fetal Brain
Sources

Publications for Placental Insufficiency

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Articles related to Placental Insufficiency:

(show top 50) (show all 252)
# Title Authors Year
1
Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency. ( 29536649 )
2018
2
Recombinant human soluble thrombomodulin as an anticoagulation therapy improves recurrent miscarriage and fetal growth restriction due to placental insufficiency - The leading cause of preeclampsia. ( 29908636 )
2018
3
Study of mitochondrial function in placental insufficiency. ( 29941168 )
2018
4
Caspase dependent and independent mechanisms of apoptosis across gestation in a sheep model of placental insufficiency and intrauterine growth restriction. ( 28083721 )
2017
5
Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study. ( 28854913 )
2017
6
Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency. ( 28623975 )
2017
7
Maternal Choline Supplementation Alters Fetal Growth Patterns in a Mouse Model of Placental Insufficiency. ( 28718809 )
2017
8
Revealed versus concealed criteria for placental insufficiency in an unselected obstetric population in late pregnancy (RATIO37): randomised controlled trial study protocol. ( 28619771 )
2017
9
In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study. ( 28623277 )
2017
10
Maternal Obesity and Male Genital Anomalies: Potential Role of Placental Insufficiency and Metabolic Syndrome. ( 28815740 )
2017
11
Effect of Transdermal Nitroglycerine on Doppler Velocity Waveforms of the Uterine, Umbilical and Fetal Middle Cerebral Arteries in Patients with Chronic Placental Insufficiency: A Prospective RCT. ( 28892981 )
2017
12
The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-I^ in Pregnancy Complicated by Placental Insufficiency. ( 28698875 )
2017
13
Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency. ( 28194805 )
2017
14
Livebirth and utero-placental insufficiency in Papio hamadryas baboons with uterus angiosome perfused by bilateral utero-ovarian microsurgical anastomoses alone. ( 28854716 )
2017
15
Novel Detection of Placental Insufficiency by Magnetic Resonance Imaging in the Nonhuman Primate. ( 28330415 )
2017
16
Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. ( 28295343 )
2017
17
Screening for fetal growth restriction and placental insufficiency. ( 29221766 )
2017
18
Enhanced insulin secretion and insulin sensitivity in young lambs with placental insufficiency-induced intrauterine growth restriction. ( 28490449 )
2017
19
Impact of placental insufficiency on fetal skeletal muscle growth. ( 26994511 )
2016
20
Placental insufficiency among high-risk pregnancies with a normal umbilical artery resistance index after 32weeks. ( 27515046 )
2016
21
MR Imaging of Fetuses to Evaluate Placental Insufficiency. ( 26607809 )
2016
22
Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model. ( 27806942 )
2016
23
Disease-Modifying Drug Possibly Linked to Placental Insufficiency: Severe placental complications in a pregnant woman with multiple sclerosis. ( 27606121 )
2016
24
Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency. ( 26880769 )
2016
25
Placental Insufficiency in Fetuses That Slow in Growth but Are Born Appropriate for Gestational Age: A Prospective Longitudinal Study. ( 26730589 )
2016
26
Increased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis. ( 26903689 )
2016
27
Longitudinal maternal haemodynamics in fetal growth restriction in pregnancies at high risk for placental insufficiency. ( 27854379 )
2016
28
Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency. ( 26599800 )
2016
29
Maternal Calorie Restriction Causing Utero-placental Insufficiency Differentially Affects Mammalian Placental Glucose and Leucine Transport Molecular Mechanisms. ( 27494059 )
2016
30
Definitions and reporting of placental insufficiency in biomedical journals: a review of the literature. ( 27591716 )
2016
31
[OP.5D.06] HYPERTENSION AS A PATERNAL FACTOR INFLUENCES MATERNAL ADAPTATION TO PREGNANCY AND IS ASSOCIATED WITH PLACENTAL INSUFFICIENCY AND FETAL GROWTH RESTRICTION. ( 27508762 )
2016
32
Fetal growth according to different reference ranges in twin pregnancies with placental insufficiency. ( 26735222 )
2015
33
Computerized fetal heart rate analysis in the prediction of myocardial damage in pregnancies with placental insufficiency. ( 25917436 )
2015
34
Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay. ( 25485869 )
2015
35
Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production. ( 26723529 )
2015
36
Effects of transcutaneous electrical nerve stimulation on fetal and placental development in an experimental model of placental insufficiency. ( 25567559 )
2015
37
Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies-reply. ( 26030513 )
2015
38
Prevention of Defective Placentation and Pregnancy Loss by Blocking Innate Immune Pathways in a Syngeneic Model of Placental Insufficiency. ( 26071558 )
2015
39
Low-molecular-weight heparin and placental insufficiency: miracle drug or modern day blood letting? ( 26192695 )
2015
40
The 4G/4G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene as an independent risk factor for placental insufficiency, which triggers fetal hemodynamic centralization. ( 25723084 )
2015
41
Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies. ( 26030512 )
2015
42
[92-OR]: Placental growth factor measurement as a marker of subsequent disease and harm in placental insufficiency conditions. ( 25787444 )
2015
43
Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn rat following placental insufficiency. ( 26014855 )
2015
44
Altered amniotic fluid leptin levels in twin-twin transfusion syndrome with concurrent placental insufficiency. ( 25248665 )
2014
45
Hyperreactio luteinalis: timely diagnosis minimizes the risk of oophorectomy and alerts clinicians to the associated risk of placental insufficiency. ( 24630301 )
2014
46
Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep. ( 25249573 )
2014
47
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. ( 25245499 )
2014
48
Placental findings in late-onset SGA births without Doppler signs of placental insufficiency. ( 24138874 )
2013
49
Imbalance of expression of bFGF and PK1 is associated with defective maturation and antenatal placental insufficiency. ( 23891065 )
2013
50
Doppler velocimetry of the fetal middle cerebral artery and other parameters of fetal well-being in neonatal survival during pregnancies with placental insufficiency. ( 23849713 )
2013
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Variations for Placental Insufficiency

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Expression for Placental Insufficiency

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Search GEO for disease gene expression data for Placental Insufficiency.
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Pathways for Placental Insufficiency

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Pathways related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 64
Show member pathways
 13.27 ANGPT2 FLT1 KDR PGF PROK1 TEK
2
TGF-Beta Pathway 64
Show member pathways
 13.21 ANGPT2 F2 FLT1 KDR PGF PROK1
3
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 13.17 ANGPT2 F2 F3 FGR TEK VEGFA
4
PAK Pathway 64
Show member pathways
 13.15 ANGPT2 FLT1 KDR PGF PROK1 TEK
5
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 13.12 FLT1 KDR PGF PROK1 TEK VEGFA
6
p70S6K Signaling 64
Show member pathways
 12.91 F2 FLT1 KDR PGF PROK1
7
PI3K-Akt signaling pathway 37
Show member pathways
 12.83 ANGPT2 FLT1 KDR PGF TEK VEGFA
8
Focal Adhesion 37 1
Show member pathways
 12.74 FGR FLT1 KDR PGF VEGFA
9
NF-KappaB Family Pathway 64
Show member pathways
 12.57 FLT1 KDR PGF PROK1
10
MAPK signaling pathway 1 37
12.55 ANGPT2 FLT1 KDR PGF TEK VEGFA
11
Ras signaling pathway 37
Show member pathways
 12.49 ANGPT2 FLT1 KDR PGF TEK VEGFA
12
Immune response IL-23 signaling pathway 22
Show member pathways
 12.45 ANGPT2 F2 SOCS3 TEK
13
VEGF Pathway (Qiagen) 64
Show member pathways
 12.27 FLT1 KDR PGF VEGFA
14
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.96 ANGPT2 FLT1 KDR PGF PROK1
15
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.94 AFP KDR VEGFA
16
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 11.93 FLT1 KDR TEK
17
EPHA forward signaling 1
Show member pathways
 11.86 FGR KDR VEGFA
18
S1P3 pathway 1
Show member pathways
 11.86 FLT1 KDR VEGFA
19
HIF-1 signaling pathway 37
11.76 ANGPT2 FLT1 TEK VEGFA
20
Rheumatoid arthritis 37
11.71 FLT1 TEK VEGFA
21
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.7 FLT1 KDR PGF VEGFA
22
Angiogenesis (CST) 4
11.6 ANGPT2 F3 FLT1 KDR TEK
23
Signaling events mediated by PTP1B 1
11.43 FGR LEP SOCS3
24
Vemurafenib Pathway, Pharmacodynamics 61
11.34 FLT1 KDR VEGFA
25
Tyrosine Kinases / Adaptors 4
11.27 ANGPT2 FGR FLT1 KDR SOCS3 TEK
26
HIF-2-alpha transcription factor network 1
11.22 FLT1 KDR VEGFA
27
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 11.15 LEP SOCS3 VEGFA
28
Glypican 1 network 1
11.07 FGR FLT1 VEGFA
29
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.92 SOCS3 VEGFA
30
Angiogenesis (WikiPathways) 1
10.84 FLT1 KDR TEK VEGFA
31
VEGF ligand-receptor interactions 66
Show member pathways
 10.46 FLT1 KDR PGF VEGFA
Sources

GO Terms for Placental Insufficiency

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Cellular components related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AFP ANGPT2 F2 F3 FLT1 LEP
2 extracellular region GO:0005576 9.4 AFP ANGPT2 F2 F3 FGR FLT1

Biological processes related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 FLT1 KDR LEP SOCS3 TEK VEGFA
2 protein autophosphorylation GO:0046777 9.93 FGR FLT1 KDR TEK
3 peptidyl-tyrosine phosphorylation GO:0018108 9.92 FGR FLT1 KDR TEK
4 positive regulation of protein phosphorylation GO:0001934 9.91 F2 KDR TEK VEGFA
5 regulation of cell shape GO:0008360 9.91 F2 FGR KDR VEGFA
6 positive regulation of MAPK cascade GO:0043410 9.89 FLT1 KDR LEP TEK
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.87 FGR FLT1 KDR TEK
8 positive regulation of cell proliferation GO:0008284 9.86 EMP2 F2 FLT1 KDR LEP PGF
9 positive regulation of cell migration GO:0030335 9.85 F3 FGR FLT1 KDR VEGFA
10 positive regulation of kinase activity GO:0033674 9.84 FLT1 KDR TEK
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 LEP SOCS3 VEGFA
12 negative regulation of signal transduction GO:0009968 9.84 FLT1 KDR SOCS3 TEK
13 vasculogenesis GO:0001570 9.83 FLT1 KDR VEGFA
14 positive regulation of endothelial cell migration GO:0010595 9.81 KDR TEK VEGFA
15 positive regulation of cell division GO:0051781 9.8 PGF PROK1 VEGFA
16 response to hypoxia GO:0001666 9.8 ANGPT2 LEP PGF TEK TH VEGFA
17 response to activity GO:0014823 9.77 ANGPT2 LEP TH
18 positive regulation of endothelial cell proliferation GO:0001938 9.77 F3 KDR PGF TEK VEGFA
19 regulation of angiogenesis GO:0045765 9.75 EMP2 LEP PROK1
20 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.73 FLT1 KDR PGF VEGFA
21 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.72 FGR FLT1 TEK
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.7 FLT1 KDR VEGFA
23 positive regulation of JAK-STAT cascade GO:0046427 9.69 F2 LEP
24 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.69 FLT1 VEGFA
25 sprouting angiogenesis GO:0002040 9.69 FLT1 PGF TEK
26 eye photoreceptor cell development GO:0042462 9.68 TH VEGFA
27 cell migration involved in sprouting angiogenesis GO:0002042 9.68 KDR VEGFA
28 induction of positive chemotaxis GO:0050930 9.68 PGF VEGFA
29 vascular endothelial growth factor signaling pathway GO:0038084 9.68 FLT1 KDR
30 sexual reproduction GO:0019953 9.67 AFP LEP
31 ovulation from ovarian follicle GO:0001542 9.67 AFP LEP
32 positive regulation of mast cell chemotaxis GO:0060754 9.65 PGF VEGFA
33 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 KDR VEGFA
34 positive regulation of focal adhesion assembly GO:0051894 9.65 KDR TEK VEGFA
35 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 F2 FGR FLT1 KDR LEP TEK
36 glomerulus vasculature development GO:0072012 9.62 ANGPT2 TEK
37 Tie signaling pathway GO:0048014 9.58 ANGPT2 TEK
38 positive regulation of positive chemotaxis GO:0050927 9.58 F3 KDR VEGFA
39 positive regulation of angiogenesis GO:0045766 9.5 ANGPT2 F3 FLT1 KDR PGF TEK
40 angiogenesis GO:0001525 9.23 ANGPT2 FLT1 KDR LEP PGF PROK1
41 multicellular organism development GO:0007275 10.19 ANGPT2 F2 FLT1 KDR PGF TEK
42 cell differentiation GO:0030154 10.1 ANGPT2 FGR FLT1 KDR PGF TEK
43 regulation of signaling receptor activity GO:0010469 10.05 F2 LEP PGF PROK1 VEGFA

Molecular functions related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.61 FLT1 KDR TEK
2 mitogen-activated protein kinase kinase binding GO:0031434 9.58 FLT1 KDR TEK
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 FLT1 KDR TEK
4 growth factor binding GO:0019838 9.43 FLT1 KDR TEK
5 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 FLT1 KDR
6 protein tyrosine kinase activity GO:0004713 9.26 FGR FLT1 KDR TEK
7 vascular endothelial growth factor receptor binding GO:0005172 9.16 PGF VEGFA
8 growth factor activity GO:0008083 8.92 F2 PGF PROK1 VEGFA
Sources

Sources for Placental Insufficiency

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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