MCID: PLC005
MIFTS: 55

Placental Insufficiency

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Placental Insufficiency

MalaCards integrated aliases for Placental Insufficiency:

Name: Placental Insufficiency 12 59 55 44 15 17 72
Uteroplacental Vascular Insufficiency 59

Characteristics:

Orphanet epidemiological data:

59
placental insufficiency
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3891
MeSH 44 D010927
ICD10 via Orphanet 34 O36.5
UMLS via Orphanet 73 C0032051
Orphanet 59 ORPHA439167
UMLS 72 C0032051

Summaries for Placental Insufficiency

Disease Ontology : 12 A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

MalaCards based summary : Placental Insufficiency, also known as uteroplacental vascular insufficiency, is related to eclampsia and twin-to-twin transfusion syndrome. An important gene associated with Placental Insufficiency is PGF (Placental Growth Factor), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and TGF-Beta Pathway. The drugs tannic acid and Enoxaparin have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related phenotypes are intrauterine growth retardation and hypoxemia

Wikipedia : 75 Placental insufficiency or utero-placental insufficiency is the failure of the placenta to deliver... more...

Related Diseases for Placental Insufficiency

Diseases related to Placental Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 eclampsia 31.2 PGF FLT1 F2
2 twin-to-twin transfusion syndrome 30.3 PGF FLT1 ANGPT2
3 placental abruption 30.1 PGF FLT1 F2
4 placenta disease 29.8 PGF IL6 F3 AFP
5 severe pre-eclampsia 29.5 VEGFA PGF LEP FGR APLN
6 vascular disease 29.2 VEGFA IL6 F3 F2
7 hellp syndrome 29.0 PGF IL6 FLT1 F3 F2
8 pre-eclampsia 28.0 VEGFA PGF LEP KDR IL6 FLT1
9 antiphospholipid syndrome 11.6
10 cholestasis, intrahepatic, of pregnancy, 1 11.3
11 cholestasis, intrahepatic, of pregnancy 3 11.3
12 glomeruloid hemangioma 10.6 VEGFA FLT1
13 hematocele of tunica vaginalis testis 10.5 ANGPT2 AFP
14 cancer-associated retinopathy 10.5 VEGFA PGF FLT1
15 mild pre-eclampsia 10.5 PGF LEP FLT1
16 microcystic meningioma 10.5 VEGFA FLT1
17 lipodermatosclerosis 10.5 VEGFA FLT1 ANGPT2
18 sick building syndrome 10.4 VEGFA LEP
19 microvascular complications of diabetes 1 10.4 VEGFA FLT1 ANGPT2
20 endometrial small cell carcinoma 10.4 F2 AFP
21 pyogenic granuloma 10.4 VEGFA TEK ANGPT2
22 retinal vascular occlusion 10.3 VEGFA PGF F2
23 obesity-hypoventilation syndrome 10.3 LEP IL6
24 peliosis hepatis 10.3 VEGFA F2 AFP
25 angiokeratoma circumscriptum 10.2 VEGFA KDR FLT1
26 skin hemangioma 10.2 VEGFA KDR FLT1
27 anca-associated vasculitis 10.2 IL6 ANGPT2
28 sudden sensorineural hearing loss 10.2 IL6 F2
29 vascular cancer 10.2 VEGFA KDR FLT1
30 breast carcinoma in situ 10.2 VEGFA IL6 FLT1
31 ischemic colitis 10.2 VEGFA F2
32 hypoglycemia 10.2
33 epileptic encephalopathy, childhood-onset 10.2 VEGFA KDR ANGPT2
34 uterine anomalies 10.1 VEGFA IL6 AFP
35 cerebral falx meningioma 10.1 F3 F2
36 fournier gangrene 10.1 F3 F2
37 intestinal impaction 10.1 F3 F2
38 diabetic macular edema 10.1 VEGFA TEK IL6
39 prothrombin deficiency 10.1 F3 F2
40 leech infestation 10.1 F3 F2
41 cerebral sinovenous thrombosis 10.1 F3 F2
42 funisitis 10.1
43 giant hemangioma 10.1 F3 F2
44 epithelioid hemangioendothelioma 10.1 VEGFA PGF KDR FLT1
45 central retinal vein occlusion 10.1 VEGFA IL6 F2
46 retinal vein occlusion 10.0 VEGFA IL6 F2
47 qualitative platelet defect 10.0 F3 F2
48 retinal artery occlusion 10.0 VEGFA IL6 F2
49 hypoxia 10.0
50 retinal vascular disease 10.0 VEGFA PGF KDR FLT1

Graphical network of the top 20 diseases related to Placental Insufficiency:



Diseases related to Placental Insufficiency

Symptoms & Phenotypes for Placental Insufficiency

Human phenotypes related to Placental Insufficiency:

59 32 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
2 hypoxemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0012418
3 small for gestational age 59 32 hallmark (90%) Very frequent (99-80%) HP:0001518
4 small placenta 59 32 hallmark (90%) Very frequent (99-80%) HP:0006266
5 proportionate short stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0003508
6 abnormal umbilical cord blood vessels 59 32 hallmark (90%) Very frequent (99-80%) HP:0011403
7 autism 59 32 frequent (33%) Frequent (79-30%) HP:0000717
8 neurodevelopmental abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0012759
9 systemic lupus erythematosus 59 32 frequent (33%) Frequent (79-30%) HP:0002725
10 antiphospholipid antibody positivity 59 32 frequent (33%) Frequent (79-30%) HP:0003613
11 abnormal lung morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0002088
12 preeclampsia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100602
13 cerebral palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0100021
14 spontaneous abortion 59 32 occasional (7.5%) Occasional (29-5%) HP:0005268
15 abnormal heart morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0001627
16 insulin resistance 59 32 occasional (7.5%) Occasional (29-5%) HP:0000855
17 eclampsia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100601
18 maternal hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0008071
19 autistic behavior 59 Frequent (79-30%)
20 abnormality of the placenta 59 Obligate (100%)

GenomeRNAi Phenotypes related to Placental Insufficiency according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.8 FGR FLT1 TEK

MGI Mouse Phenotypes related to Placental Insufficiency:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.38 ANGPT2 APLN EMP2 F2 F3 FGR
2 homeostasis/metabolism MP:0005376 10.29 AFP ANGPT2 APLN F2 F3 FLT1
3 behavior/neurological MP:0005386 10.25 AFP APLN F2 F3 FLT1 IL6
4 growth/size/body region MP:0005378 10.25 APLN F2 F3 FLT1 IL6 KDR
5 embryo MP:0005380 10.22 APLN EMP2 F2 F3 FLT1 KDR
6 immune system MP:0005387 10.2 ANGPT2 EMP2 F2 F3 FGR FLT1
7 hematopoietic system MP:0005397 10.19 EMP2 F2 F3 FGR FLT1 IL6
8 mortality/aging MP:0010768 10.14 AFP ANGPT2 F2 F3 FLT1 IL6
9 integument MP:0010771 10.09 ANGPT2 F2 F3 IL6 KDR LEP
10 muscle MP:0005369 9.97 APLN F3 FLT1 IL6 KDR LEP
11 nervous system MP:0003631 9.91 F2 F3 FLT1 IL6 KDR LEP
12 neoplasm MP:0002006 9.87 AFP F3 IL6 LEP PGF TH
13 normal MP:0002873 9.76 F2 F3 FGR FLT1 KDR TEK
14 respiratory system MP:0005388 9.61 ANGPT2 F2 F3 IL6 KDR LEP
15 vision/eye MP:0005391 9.36 ANGPT2 APLN F3 FLT1 IL6 KDR

Drugs & Therapeutics for Placental Insufficiency

Drugs for Placental Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Enoxaparin Approved Phase 4 9005-49-6 772
3
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
6
Dalteparin Approved Phase 3 9005-49-6
7
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
8
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
9
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
10 Heparin, Low-Molecular-Weight Phase 3
11 Anticoagulants Phase 3
12 Calcium, Dietary Phase 3
13 Chelating Agents Phase 3
14 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
15 Citrate Phase 2, Phase 3
16 Phosphodiesterase Inhibitors Phase 2, Phase 3
17 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
18 Vasodilator Agents Phase 2, Phase 3
19
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
20
Heparin Approved, Investigational Phase 2 9005-49-6 46507594 772
21
Certolizumab pegol Approved Phase 2 428863-50-7
22 Cyclooxygenase Inhibitors Phase 2
23 Analgesics, Non-Narcotic Phase 2
24 Peripheral Nervous System Agents Phase 2
25 Fibrinolytic Agents Phase 2
26 Analgesics Phase 2
27 Anti-Inflammatory Agents, Non-Steroidal Phase 2
28 Platelet Aggregation Inhibitors Phase 2
29 Antipyretics Phase 2
30 Anti-Inflammatory Agents Phase 2
31 Antirheumatic Agents Phase 2
32 calcium heparin Phase 2
33 Immunologic Factors Phase 2
34 Immunosuppressive Agents Phase 2
35
Allopurinol Approved 315-30-0 2094
36
Ondansetron Approved 99614-02-5 4595
37 Coconut Approved
38
Iron Approved, Experimental 15438-31-0, 7439-89-6 23925 27284
39
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
40 Antioxidants
41 Free Radical Scavengers
42 Protective Agents
43 Antimetabolites
44 Lupus Coagulation Inhibitor
45 Antibodies, Antiphospholipid
46 Antibodies, Anticardiolipin
47 Angiogenesis Inhibitors
48 Angiogenesis Modulating Agents
49 Angiogenesis Inducing Agents
50 Pharmaceutical Solutions

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Enoxaparine en PREvention Des insuffiSAnces Placentaires Chez Les Femmes eNCEintes Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
2 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
3 A Prospective Multi-centre Randomised Comparison on Induction of Labour With Double-balloon Installation Device Versus Prostaglandin E2 Minprostin Completed NCT01255839 Phase 4 Minprostin
4 Pilot Double-Blind Placebo Controlled Trial of Levothyroxine in Pregnant Systemic Lupus Erythematosus (SLE) Patients With Autoimmune Thyroid Disease Withdrawn NCT01276782 Phase 4 Levothyroxine
5 Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment Unknown status NCT03230162 Phase 3 Sildenafil;low molecular weight heparin
6 Enoxaparin for the Prevention of Placental‐Mediated Complications of Pregnancy in Women With Obstetric History or Abnormal Uterine Artery Doppler at First Trimester Ultrasound and Without Thrombophilia: a Multicenter Randomized Controlled Trial Completed NCT01388322 Phase 3 Enoxaparin
7 A Randomized Controlled Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
8 The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction) Terminated NCT02277132 Phase 2, Phase 3 Sildenafil;Placebo
9 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
10 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
11 Certolizumab to Prevent Pregnancy Complications in High-Risk Patients With APS or SLE - (IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy) Recruiting NCT03152058 Phase 2 Certolizumab Pegol
12 Does Antenatal Allopurinol Administration Improve Maternal and Neonatal Outcome in Intrauterine Growth Restriction? Unknown status NCT00346463 Allopurinol
13 Revealed Versus Concealed Criteria for Placental Insufficiency in Unselected Obstetric Population in Late Pregnancy: a Multicenter Randomized Controlled Trial Unknown status NCT02907242
14 The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies Unknown status NCT01384136
15 Variability in Middle Cerebral Artery Doppler Measurements in Uncomplicated Term Pregnancies. Unknown status NCT02968017
16 Ultrasound Monitoring of Fetuses With Vascular Intra-uterine Growth Restriction (IUGR) Using the Isthmus Systolic Index (ISI): Feasibility, Comparison to Normal Fetuses and Association With Perinatal Mortality Unknown status NCT02813525
17 Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia Unknown status NCT02699437
18 A Prospective, Randomized Multicenter Trial of Amnioreduction Vs Selective Fetoscopic Laser Photocoagulation for the Treatment of Severe Twin-Twin Transfusion Syndrome Unknown status NCT00345852
19 First-trimester Study of the Morphometric Characteristics of the Placenta to Assess the Risk of Preeclampsia and Intrauterine Growth Restriction in Singleton Pregnancies Unknown status NCT02879942
20 Screening for Placental Insufficiency by a Combination of Second Trimester Uterine Artery Doppler and Maternal Serum Leptin and Lipids Completed NCT00465634
21 Placental Insufficiency Screening During First Trimester by a Combination of Uterine Artery Dopppler, Maternal PlGF and sFLT-1 in Hight Risk Population Completed NCT01348711
22 Promoting Awareness Fetal Movements and Focussing Interventions Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial. Completed NCT01777022
23 Intraumbilical Amino Acids and Glucose Supplementation Via Subcutaneously Implanted Port System by Severe IUGR Human Fetuses Completed NCT02596594
24 Comparative Study of Plasma Free DNA and Nucleosome Concentrations: Pathological Versus Normal Pregnancies Completed NCT01736826
25 Correlation Between Perineuraxial Anesthesia Fluid Resuscitation in Cesarean Section and Infant Neurobehaviors Completed NCT00987701 Ringer's Lactate;Six percent hydroxyethyl starch
26 The Evaluation of UTERO - Placental 3D Doppler Examination Potential Interest for Pre- Eclampsia Screening During Pregnancy. Observational Study in 100 Women at High Risk for Pre- Eclampsia and 70 Low Risk Women. Completed NCT00930397
27 Splanchnic Oxygenation and Perfusion Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler: Pattern Assessment and Correlation With Feeding Intolerance Completed NCT02971566
28 Protocol for Testing the Efficiency of a Device Meant to Relieve Labour Pain Completed NCT00426725
29 Are Renal Artery Doppler Indices Different Between Monochorionic Diamniotic Twins With Twin-twin Transfusion Syndrome and Monochorionic Diamniotic Twins Without Twin-twin Transfusion Syndrome? Completed NCT03449823
30 Walking and Dietary Modification for Women With Consecutive Early Miscarriages: a Randomized Study Completed NCT03023137
31 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
32 Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency Recruiting NCT03731546
33 Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler: an Observational Prospective Study Recruiting NCT03860103
34 Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight Recruiting NCT03187938
35 Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency Recruiting NCT03731611
36 MRI Assessment of Placental Health Recruiting NCT02297724
37 The PREPPeD Study: "PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome" Recruiting NCT03100084
38 Imaging Innovations for Placental Assessment in Response to Environmental Pollution Recruiting NCT02786420
39 Doppler Echocardiography Assessment of Cardiac Sparing Effect in Fetal Hypoxia Recruiting NCT03146507
40 Effect of L-Arginine on Intrauterine Growth Restriction Fetuses Measured by Birth Weight: Randomized Controlled Trial Recruiting NCT03321292 L-arginine 1000 mg and Acetylesalicylic acid75mg;acetylsalicylic acid 75 mg
41 Frequency of Performing Umbilical Artery Doppler in the Third Trimester in High Risk Pregnancy A Randomized Controlled Trial Recruiting NCT03584763
42 Study of the Fetoplacental BOLD Effect in Pregnant Women Using Functional MRI Recruiting NCT02238301
43 Preeclampsia Ratio (sFlt-1/PlGF) Evaluation for Clinical and Obstetrical Guidance Recruiting NCT03289611
44 The Lupus prEGnAnCY Cohort: An International Prospective Cohort of Lupus Pregnancies Recruiting NCT03746028
45 Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE Active, not recruiting NCT01092949
46 Oxygen for Category II Intrauterine Fetal Resuscitation: A Randomized, Noninferiority Trial Active, not recruiting NCT02741284 Room air;10L Oxygen by nonrebreather mask
47 Effect of Maternal Iron Deficiency Anemia on Fetal Hemodynamics and Neonatal Outcome Not yet recruiting NCT04016922
48 Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities: a Randomized Clinical Trial Not yet recruiting NCT03996317

Search NIH Clinical Center for Placental Insufficiency

Cochrane evidence based reviews: placental insufficiency

Genetic Tests for Placental Insufficiency

Anatomical Context for Placental Insufficiency

MalaCards organs/tissues related to Placental Insufficiency:

41
Placenta, Heart, Brain, Testes, Lung, Fetal Brain, Endothelial

Publications for Placental Insufficiency

Articles related to Placental Insufficiency:

(show top 50) (show all 1742)
# Title Authors PMID Year
1
Reduced maternal serum concentrations of angiopoietin-2 in the first trimester precede intrauterine growth restriction associated with placental insufficiency. 9 38
17949380 2007
2
The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction. 9 38
12740423 2003
3
Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice. 9 38
12163461 2002
4
Placental expression of VEGF, PlGF and their receptors in a model of placental insufficiency-intrauterine growth restriction (PI-IUGR). 9 38
11945079 2002
5
Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. 9 38
11397868 2001
6
Chronic hypoxemia: effects on developing nitrergic and dopaminergic amacrine cells. 9 38
10359329 1999
7
[The importance of determining trophoblastic beta 1-glycoprotein (TBG) for the early diagnosis and prognosis of placental insufficiency in pregnant women with habitual abortion]. 9 38
1814220 1991
8
Disrupted placental serotonin synthetic pathway and increased placental serotonin: Potential implications in the pathogenesis of human fetal growth restriction. 38
31176514 2019
9
Early psychosocial development of small for gestational age and intrauterine growth-restricted children: a systematic review. 38
30967654 2019
10
Achieving orphan designation for placental insufficiency: annual incidence estimations in Europe. 38
30576053 2019
11
Pharmacological activation of peroxisome proliferator-activated receptor γ (PPAR-γ) protects against hypoxia-associated fetal growth restriction. 38
31039323 2019
12
Spontaneous superimposed preeclampsia: chronology and expression unveiled by temporal transcriptomic analysis. 38
31125289 2019
13
Offspring from maternal nutrient restriction in mice show variations in adult glucose metabolism similar to human fetal growth restriction. 38
30501657 2019
14
Prenatal testosterone excess disrupts placental function in a sheep model of polycystic ovary syndrome. 38
31436841 2019
15
The placenta: A site of end-organ damage after Fontan operation. A case series. 38
30765280 2019
16
Δ9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. 38
31054322 2019
17
Cumulative Antenatal Risk and Kindergarten Readiness in Preterm-Born Preschoolers. 38
31418097 2019
18
Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. 38
31318420 2019
19
The biological function of ELABELA and APJ signaling in the cardiovascular system and pre-eclampsia. 38
30626933 2019
20
Early-Pregnancy Circulating Antioxidant Capacity and Hemodynamic Adaptation in Recurrent Placental Syndrome: An Exploratory Study. 38
31357192 2019
21
Fetal hyperglycemia acutely induces persistent insulin resistance in skeletal muscle. 38
30444716 2019
22
Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. 38
31336074 2019
23
The sFlt-1/PlGF ratio values within the <38, 38-85 and >85 brackets as compared to perinatal outcomes. 38
31339858 2019
24
Risk of ischemic placental disease is increased following in vitro fertilization with oocyte donation: a retrospective cohort study. 38
31359234 2019
25
CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34+ cell presence, and autophagy in the endometrium†. 38
31004477 2019
26
Placental Creatine Metabolism in Cases of Placental Insufficiency and Reduced Fetal Growth. 38
31323678 2019
27
[Splanchnic oximetry in small for gestational age neonates in relation to prenatal doppler study]. 38
31350206 2019
28
Results of full postmortem examination in a cohort of clinically unexplained stillbirths: undetected fetal growth restriction and placental insufficiency are prevalent findings. 38
31266993 2019
29
Proteomics analysis of fetal growth restriction and taurine‑treated fetal growth restriction rat brain tissue by 2D DIGE and MALDI‑TOF/TOF MS analysis. 38
31115483 2019
30
Increased Pyruvate Dehydrogenase Activity in Skeletal Muscle of Growth Restricted Ovine Fetuses. 38
31314546 2019
31
Fetal heart rate monitoring and neonatal outcome in a population of early- and late-onset intrauterine growth restriction. 38
31099119 2019
32
Effects of maternal smoking on human placental vascularization: A systematic review. 38
31307732 2019
33
The relationship between the placental serotonin pathway and fetal growth restriction. 38
30605696 2019
34
The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome. 38
31138428 2019
35
Acute Hypoxia and Chronic Ischemia Induce Differential Total Changes in Placental Epigenetic Modifications. 38
30223723 2019
36
Breastfeeding a small for gestational age infant, complicated by maternal gestational diabetes: a case report. 38
31226953 2019
37
Protect-me: a parallel-group, triple blinded, placebo-controlled randomised clinical trial protocol assessing antenatal maternal melatonin supplementation for fetal neuroprotection in early-onset fetal growth restriction. 38
31230020 2019
38
Periconceptional alcohol exposure causes female-specific perturbations to trophoblast differentiation and placental formation in the rat. 38
31182432 2019
39
The Reactivity Levels of Progesterone, Nitric Oxide and Nuclear Factor Kappa-B on the Serum of Term and Post-Term Pregnancy, Clinical Study in Padang, West Sumatera, Indonesia. 38
31316649 2019
40
In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging. 38
30700836 2019
41
Developmental programming of adult haematopoiesis system. 38
31226498 2019
42
Evaluation of the quality and reliability of middle cerebral artery and umbilical artery Doppler images within an international randomized controlled trial. 38
31180608 2019
43
Intrauterine growth restriction and neonatal hypoxic ischemic brain injury causes sex-specific long-term neurobehavioral abnormalities in rats. 38
30843634 2019
44
Aldehyde dehydrogenase isoforms and inflammatory cell populations are differentially expressed in term human placentas affected by intrauterine growth restriction. 38
31138432 2019
45
Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling. 38
30941904 2019
46
Clinical Importance of Low Level of PAPP-A in First Trimester of Pregnancy - An Obstetrical Dilemma in Chromosomally Normal Fetus. 38
31198458 2019
47
Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria. 38
31103060 2019
48
Distinctive patterns of placental lesions in preeclampsia versus fetal growth restriction and their association with fetoplacental Doppler. 38
31115105 2019
49
Trophoblast function is altered by decidual factors in gestational-dependant manner. 38
31103068 2019
50
Chronic Estrogen Supplementation Prevents the Increase in Blood Pressure in Female Intrauterine Growth-Restricted Offspring at 12 Months of Age. 38
30929518 2019

Variations for Placental Insufficiency

Expression for Placental Insufficiency

Search GEO for disease gene expression data for Placental Insufficiency.

Pathways for Placental Insufficiency

Pathways related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 TH TEK PROK1 PGF KDR IL6
2
Show member pathways
13.37 VEGFA TEK PROK1 PGF KDR IL6
3
Show member pathways
13.31 TEK PROK1 PGF KDR IL6 FLT1
4
Show member pathways
13.22 TEK PROK1 PGF KDR IL6 FLT1
5
Show member pathways
13.21 VEGFA TEK FGR F3 F2 ANGPT2
6
Show member pathways
13.2 TEK PROK1 PGF KDR IL6 FLT1
7
Show member pathways
13.17 VEGFA TEK PROK1 PGF KDR IL6
8
Show member pathways
12.96 PROK1 PGF KDR IL6 FLT1 F2
9
Show member pathways
12.95 PROK1 PGF KDR IL6 FLT1
10
Show member pathways
12.79 VEGFA PGF KDR FLT1 FGR
11
Show member pathways
12.78 VEGFA TEK PGF KDR IL6 FLT1
12
Show member pathways
12.62 PROK1 PGF KDR IL6 FLT1
13 12.6 VEGFA TEK PGF KDR FLT1 ANGPT2
14
Show member pathways
12.56 VEGFA TEK PGF KDR FLT1 ANGPT2
15
Show member pathways
12.48 TEK IL6 F2 ANGPT2
16
Show member pathways
12.31 VEGFA PGF KDR FLT1
17
Show member pathways
12.27 TEK PROK1 PGF KDR IL6 FLT1
19
Show member pathways
12.17 PROK1 PGF KDR IL6 FLT1
20 11.97 VEGFA KDR IL6 AFP
21 11.89 TEK KDR FLT1 FGR ANGPT2
22
Show member pathways
11.88 VEGFA KDR FLT1
23
Show member pathways
11.87 VEGFA KDR FGR
24
Show member pathways
11.86 PROK1 PGF KDR IL6 FLT1 ANGPT2
25 11.8 VEGFA IL6 F3
26
Show member pathways
11.79 VEGFA PGF KDR FLT1
27 11.78 VEGFA TEK IL6 FLT1
28 11.59 VEGFA TEK IL6 FLT1 ANGPT2
29 11.39 VEGFA KDR FLT1
30 11.3 TEK KDR FLT1 F3 ANGPT2
31 11.27 VEGFA KDR FLT1
32 11.13 VEGFA FLT1 FGR
33 10.7 TEK PROK1 PGF KDR IL6 FLT1
34 10.3 VEGFA TEK KDR FLT1

GO Terms for Placental Insufficiency

Cellular components related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 VEGFA PGF LEP IL6 FLT1 F3
2 extracellular region GO:0005576 9.47 VEGFA TEK PROK1 PGF LEP KDR

Biological processes related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 VEGFA TEK LEP KDR IL6
2 peptidyl-tyrosine phosphorylation GO:0018108 9.95 TEK KDR FLT1 FGR
3 protein autophosphorylation GO:0046777 9.94 TEK KDR FLT1 FGR
4 positive regulation of cell migration GO:0030335 9.92 VEGFA KDR FLT1 FGR F3
5 regulation of cell shape GO:0008360 9.91 VEGFA KDR FGR F2
6 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA TEK PGF KDR F2
7 response to hypoxia GO:0001666 9.85 VEGFA TH TEK PGF LEP ANGPT2
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 VEGFA LEP IL6
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.84 TEK KDR FLT1 FGR
10 positive regulation of endothelial cell migration GO:0010595 9.83 VEGFA TEK KDR
11 positive regulation of cell division GO:0051781 9.82 VEGFA PROK1 PGF
12 response to activity GO:0014823 9.8 TH LEP ANGPT2
13 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.8 VEGFA PGF KDR FLT1
14 positive regulation of endothelial cell proliferation GO:0001938 9.8 VEGFA TEK PGF KDR F3
15 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.77 VEGFA KDR FLT1
16 sprouting angiogenesis GO:0002040 9.77 VEGFA TEK PGF
17 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.76 TEK FLT1 FGR
18 positive regulation of MAPK cascade GO:0043410 9.76 LEP KDR IL6 FLT1
19 positive regulation of JAK-STAT cascade GO:0046427 9.73 LEP IL6 F2
20 regulation of angiogenesis GO:0045765 9.73 PROK1 LEP IL6 EMP2
21 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.73 TEK LEP KDR FLT1 FGR F2
22 positive regulation of focal adhesion assembly GO:0051894 9.72 VEGFA TEK KDR
23 positive regulation of angiogenesis GO:0045766 9.7 VEGFA TEK PGF KDR FLT1 F3
24 cell migration involved in sprouting angiogenesis GO:0002042 9.68 VEGFA KDR
25 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 VEGFA FLT1
26 eye photoreceptor cell development GO:0042462 9.68 VEGFA TH
27 induction of positive chemotaxis GO:0050930 9.68 VEGFA PGF
28 sexual reproduction GO:0019953 9.67 LEP AFP
29 negative regulation of lipid storage GO:0010888 9.67 LEP IL6
30 ovulation from ovarian follicle GO:0001542 9.67 LEP AFP
31 positive regulation of mast cell chemotaxis GO:0060754 9.66 VEGFA PGF
32 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 VEGFA KDR
33 positive regulation of positive chemotaxis GO:0050927 9.65 VEGFA KDR F3
34 positive regulation of cell proliferation GO:0008284 9.65 VEGFA PROK1 PGF LEP KDR IL6
35 negative regulation of vasoconstriction GO:0045906 9.63 LEP APLN
36 glomerulus vasculature development GO:0072012 9.63 TEK ANGPT2
37 vascular endothelial growth factor signaling pathway GO:0038084 9.62 VEGFA PGF KDR FLT1
38 Tie signaling pathway GO:0048014 9.61 TEK ANGPT2
39 angiogenesis GO:0001525 9.28 VEGFA TEK PROK1 PGF LEP KDR
40 multicellular organism development GO:0007275 10.16 VEGFA PGF KDR FLT1 F2 APLN
41 cell differentiation GO:0030154 10.05 VEGFA PGF KDR FLT1 FGR ANGPT2

Molecular functions related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.65 LEP FGR F2 APLN ANGPT2
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 TEK KDR FLT1
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 KDR FLT1
4 growth factor binding GO:0019838 9.33 TEK KDR FLT1
5 protein tyrosine kinase activity GO:0004713 9.26 TEK KDR FLT1 FGR
6 growth factor activity GO:0008083 9.02 VEGFA PROK1 PGF IL6 F2

Sources for Placental Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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