MCID: PLC005
MIFTS: 57

Placental Insufficiency

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Placental Insufficiency

MalaCards integrated aliases for Placental Insufficiency:

Name: Placental Insufficiency 12 58 54 43 15 17 71
Uteroplacental Vascular Insufficiency 58

Characteristics:

Orphanet epidemiological data:

58
placental insufficiency
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3891
MeSH 43 D010927
ICD10 via Orphanet 33 O36.5
UMLS via Orphanet 72 C0032051
Orphanet 58 ORPHA439167
UMLS 71 C0032051

Summaries for Placental Insufficiency

Disease Ontology : 12 A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

MalaCards based summary : Placental Insufficiency, also known as uteroplacental vascular insufficiency, is related to antiphospholipid syndrome and eclampsia. An important gene associated with Placental Insufficiency is PGF (Placental Growth Factor), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Enoxaparin and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related phenotypes are intrauterine growth retardation and hypoxemia

Wikipedia : 74 Placental insufficiency or utero-placental insufficiency is the failure of the placenta to deliver... more...

Related Diseases for Placental Insufficiency

Diseases related to Placental Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 antiphospholipid syndrome 32.9 SERPINE1 PGF F3 F2
2 eclampsia 30.9 VEGFA SERPINE1 PGF PAPPA FLT1 F2
3 funisitis 30.7 IL6 CXCL8 ANGPT1
4 oligohydramnios 30.6 PGF PAPPA AFP
5 triploidy 30.6 PAPPA AFP
6 chorioangioma 30.5 ANGPT1 AFP
7 severe pre-eclampsia 30.4 VEGFA SERPINE1 PGF PAPPA LEP FGR
8 tricuspid valve insufficiency 30.3 PAPPA F3 F2
9 pyelonephritis 30.3 PGF IL6 CXCL8
10 placental abruption 30.3 PGF PAPPA FLT1 F2
11 chorioamnionitis 30.2 VEGFA IL6 FLT1 CXCL8
12 twin-to-twin transfusion syndrome 30.1 PGF PAPPA FLT1 ANGPT2 ANGPT1
13 vascular disease 29.9 VEGFA SERPINE1 LEP IL6 F3 F2
14 hypothyroidism 29.9 VEGFA SERPINE1 LEP F3 F2
15 hellp syndrome 29.6 VEGFA SERPINE1 PGF LEP IL6 FLT1
16 pre-eclampsia 29.5 VEGFA SERPINE1 PGF PAPPA LEP KDR
17 placenta disease 29.0 VEGFA PGF PAPPA MIR520A IL6 FLT1
18 hypertension, essential 27.3 VEGFA TH TEK SERPINE1 PGF PAPPA
19 cholestasis, intrahepatic, of pregnancy, 1 11.3
20 cholestasis, intrahepatic, of pregnancy 3 11.3
21 septate uterus 10.7 KDR FLT1
22 angiokeratoma of mibelli 10.6 KDR FLT1
23 osteosclerotic myeloma 10.6 VEGFA IL6
24 cancer-associated retinopathy 10.6 VEGFA PGF FLT1
25 obesity-hypoventilation syndrome 10.6 LEP IL6
26 intravascular papillary endothelial hyperplasia 10.6 VEGFA HIF1A
27 chromosomal triplication 10.6 PAPPA AFP
28 gastric hemangioma 10.6 F3 F2
29 peripartum cardiomyopathy 10.6 VEGFA PGF FLT1
30 neonatal anemia 10.6 PGF PAPPA FLT1
31 intermediate malignant teratoma 10.6 PAPPA AFP
32 sudden sensorineural hearing loss 10.6 IL6 F2
33 glomeruloid hemangioma 10.6 VEGFA IL6 FLT1
34 fournier gangrene 10.6 F3 F2
35 hypertensive encephalopathy 10.6 VEGFA PGF F2
36 synovial angioma 10.6 F3 F2
37 renal pelvis squamous cell carcinoma 10.6 F3 F2
38 blue toe syndrome 10.6 F3 F2
39 primary cutaneous b-cell lymphoma 10.6 VEGFA KDR FLT1
40 acquired hemangioma 10.6 VEGFA F3
41 patau syndrome 10.6 PGF PAPPA AFP
42 idiopathic anterior uveitis 10.5 IL6 CXCL8
43 cardiovascular cancer 10.5 VEGFA KDR FLT1
44 vascular cancer 10.5 VEGFA KDR FLT1
45 emphysematous cholecystitis 10.5 F3 F2
46 acute mountain sickness 10.5 VEGFA HIF1A FLT1
47 non-gestational ovarian choriocarcinoma 10.5 TEK AFP
48 angiodysplasia 10.5 VEGFA F3 ANGPT2
49 lymphangioma 10.5 VEGFA KDR AFP
50 streptococcal toxic-shock syndrome 10.5 IL6 CXCL8

Graphical network of the top 20 diseases related to Placental Insufficiency:



Diseases related to Placental Insufficiency

Symptoms & Phenotypes for Placental Insufficiency

Human phenotypes related to Placental Insufficiency:

58 31 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001511
2 hypoxemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012418
3 small for gestational age 58 31 hallmark (90%) Very frequent (99-80%) HP:0001518
4 small placenta 58 31 hallmark (90%) Very frequent (99-80%) HP:0006266
5 proportionate short stature 58 31 hallmark (90%) Very frequent (99-80%) HP:0003508
6 abnormal umbilical cord blood vessels 58 31 hallmark (90%) Very frequent (99-80%) HP:0011403
7 autism 58 31 frequent (33%) Frequent (79-30%) HP:0000717
8 neurodevelopmental abnormality 58 31 frequent (33%) Frequent (79-30%) HP:0012759
9 systemic lupus erythematosus 58 31 frequent (33%) Frequent (79-30%) HP:0002725
10 antiphospholipid antibody positivity 58 31 frequent (33%) Frequent (79-30%) HP:0003613
11 abnormal lung morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002088
12 preeclampsia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100602
13 cerebral palsy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100021
14 spontaneous abortion 58 31 occasional (7.5%) Occasional (29-5%) HP:0005268
15 abnormal heart morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001627
16 insulin resistance 58 31 occasional (7.5%) Occasional (29-5%) HP:0000855
17 eclampsia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100601
18 maternal hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0008071
19 autistic behavior 58 Frequent (79-30%)
20 abnormality of the placenta 58 Obligate (100%)

GenomeRNAi Phenotypes related to Placental Insufficiency according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.6 LEP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.6 F3 FLT1 LEP PAPPA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.6 PAPPA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.6 F3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.6 FLT1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.6 F3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.6 PAPPA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.6 LEP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.6 FLT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.6 PAPPA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 PAPPA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.6 PAPPA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.6 F3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.6 F3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.6 PAPPA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.6 FLT1
17 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 9.13 FGR FLT1 TEK

MGI Mouse Phenotypes related to Placental Insufficiency:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.48 ANGPT1 ANGPT2 F2 F3 FGR FLT1
2 homeostasis/metabolism MP:0005376 10.42 AFP ANGPT1 ANGPT2 F2 F3 FLT1
3 growth/size/body region MP:0005378 10.4 ANGPT1 F2 F3 FLT1 HIF1A IL6
4 immune system MP:0005387 10.32 ANGPT1 ANGPT2 F2 F3 FGR FLT1
5 hematopoietic system MP:0005397 10.29 F2 F3 FGR FLT1 HIF1A IL6
6 embryo MP:0005380 10.28 ANGPT1 F2 F3 FLT1 HIF1A KDR
7 mortality/aging MP:0010768 10.28 AFP ANGPT1 ANGPT2 F2 F3 FLT1
8 integument MP:0010771 10.27 ANGPT2 F2 F3 FGR HIF1A IL6
9 liver/biliary system MP:0005370 10.09 AFP HIF1A IL6 KDR LEP SERPINE1
10 muscle MP:0005369 10.02 ANGPT1 F3 FLT1 HIF1A IL6 KDR
11 nervous system MP:0003631 10 ANGPT1 F2 F3 FLT1 HIF1A IL6
12 neoplasm MP:0002006 9.97 AFP F3 HIF1A IL6 LEP PGF
13 normal MP:0002873 9.9 F2 F3 FGR FLT1 HIF1A KDR
14 respiratory system MP:0005388 9.73 ANGPT2 F2 F3 HIF1A IL6 KDR
15 vision/eye MP:0005391 9.4 ANGPT1 ANGPT2 F3 FLT1 HIF1A IL6

Drugs & Therapeutics for Placental Insufficiency

Drugs for Placental Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enoxaparin Approved Phase 4 9005-49-6 772
2
tannic acid Approved Phase 4 1401-55-4
3
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Dalteparin Approved Phase 3 9005-49-6
6
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
7
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
8
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
9
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
10 Heparin, Low-Molecular-Weight Phase 3
11 Anticoagulants Phase 3
12 Calcium, Dietary Phase 3
13 Chelating Agents Phase 3
14 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
15 Citrate Phase 2, Phase 3
16 Vasodilator Agents Phase 2, Phase 3
17 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
18 Phosphodiesterase Inhibitors Phase 2, Phase 3
19
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
20
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
21
Certolizumab pegol Approved Phase 2 428863-50-7
22 Fibrinolytic Agents Phase 2
23 Analgesics, Non-Narcotic Phase 2
24 Platelet Aggregation Inhibitors Phase 2
25 Antipyretics Phase 2
26 Anti-Inflammatory Agents, Non-Steroidal Phase 2
27 Analgesics Phase 2
28 Cyclooxygenase Inhibitors Phase 2
29 Anti-Inflammatory Agents Phase 2
30 Antirheumatic Agents Phase 2
31 calcium heparin Phase 2
32 Immunologic Factors Phase 2
33 Immunosuppressive Agents Phase 2
34
Allopurinol Approved 315-30-0 2094
35 Coconut Approved
36
Ondansetron Approved 99614-02-5 4595
37
Hydroxyurea Approved 127-07-1 3657
38
Iron Approved, Experimental 7439-89-6, 15438-31-0 23925 27284
39
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
40 Protective Agents
41 Free Radical Scavengers
42 Antimetabolites
43 Antioxidants
44 Angiogenesis Inhibitors
45 Angiogenesis Inducing Agents
46 Retinol palmitate
47 Anesthetics
48 retinol
49 Pharmaceutical Solutions
50 Fibrin fragment D

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Enoxaparine en PREvention Des insuffiSAnces Placentaires Chez Les Femmes eNCEintes Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
2 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
3 A Prospective Multi-centre Randomised Comparison on Induction of Labour With Double-balloon Installation Device Versus Prostaglandin E2 Minprostin Completed NCT01255839 Phase 4 Minprostin
4 Pilot Double-Blind Placebo Controlled Trial of Levothyroxine in Pregnant Systemic Lupus Erythematosus (SLE) Patients With Autoimmune Thyroid Disease Withdrawn NCT01276782 Phase 4 Levothyroxine
5 Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment Unknown status NCT03230162 Phase 3 Sildenafil;low molecular weight heparin
6 Enoxaparin for the Prevention of Placental‐Mediated Complications of Pregnancy in Women With Obstetric History or Abnormal Uterine Artery Doppler at First Trimester Ultrasound and Without Thrombophilia: a Multicenter Randomized Controlled Trial Completed NCT01388322 Phase 3 Enoxaparin
7 A Randomized Controlled Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
8 The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction) Terminated NCT02277132 Phase 2, Phase 3 Sildenafil;Placebo
9 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Unknown status NCT02678221 Phase 2 Sildenafil citrate;Aspirin
10 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
11 Certolizumab to Prevent Pregnancy Complications in High-Risk Patients With APS or SLE - (IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy) Recruiting NCT03152058 Phase 2 Certolizumab Pegol
12 Does Antenatal Allopurinol Administration Improve Maternal and Neonatal Outcome in Intrauterine Growth Restriction? Unknown status NCT00346463 Allopurinol
13 Revealed Versus Concealed Criteria for Placental Insufficiency in Unselected Obstetric Population in Late Pregnancy: a Multicenter Randomized Controlled Trial Unknown status NCT02907242
14 The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies Unknown status NCT01384136
15 Variability in Middle Cerebral Artery Doppler Measurements in Uncomplicated Term Pregnancies. Unknown status NCT02968017
16 Ultrasound Monitoring of Fetuses With Vascular Intra-uterine Growth Restriction (IUGR) Using the Isthmus Systolic Index (ISI): Feasibility, Comparison to Normal Fetuses and Association With Perinatal Mortality Unknown status NCT02813525
17 A Prospective, Randomized Multicenter Trial of Amnioreduction Vs Selective Fetoscopic Laser Photocoagulation for the Treatment of Severe Twin-Twin Transfusion Syndrome Unknown status NCT00345852
18 First-trimester Study of the Morphometric Characteristics of the Placenta to Assess the Risk of Preeclampsia and Intrauterine Growth Restriction in Singleton Pregnancies Unknown status NCT02879942
19 Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight Completed NCT03187938
20 Screening for Placental Insufficiency by a Combination of Second Trimester Uterine Artery Doppler and Maternal Serum Leptin and Lipids Completed NCT00465634
21 Placental Insufficiency Screening During First Trimester by a Combination of Uterine Artery Dopppler, Maternal PlGF and sFLT-1 in Hight Risk Population Completed NCT01348711
22 Promoting Awareness Fetal Movements and Focussing Interventions Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial. Completed NCT01777022
23 Intraumbilical Amino Acids and Glucose Supplementation Via Subcutaneously Implanted Port System by Severe IUGR Human Fetuses Completed NCT02596594
24 Comparative Study of Plasma Free DNA and Nucleosome Concentrations: Pathological Versus Normal Pregnancies Completed NCT01736826
25 Correlation Between Perineuraxial Anesthesia Fluid Resuscitation in Cesarean Section and Infant Neurobehaviors Completed NCT00987701 Ringer's Lactate;Six percent hydroxyethyl starch
26 The Evaluation of UTERO - Placental 3D Doppler Examination Potential Interest for Pre- Eclampsia Screening During Pregnancy. Observational Study in 100 Women at High Risk for Pre- Eclampsia and 70 Low Risk Women. Completed NCT00930397
27 Splanchnic Oxygenation and Perfusion Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler: Pattern Assessment and Correlation With Feeding Intolerance Completed NCT02971566
28 Are Renal Artery Doppler Indices Different Between Monochorionic Diamniotic Twins With Twin-twin Transfusion Syndrome and Monochorionic Diamniotic Twins Without Twin-twin Transfusion Syndrome? Completed NCT03449823
29 Protocol for Testing the Efficiency of a Device Meant to Relieve Labour Pain Completed NCT00426725
30 Walking and Dietary Modification for Women With Consecutive Early Miscarriages: a Randomized Study Completed NCT03023137
31 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
32 Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency Recruiting NCT03731546
33 Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler: an Observational Prospective Study Recruiting NCT03860103
34 Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency Recruiting NCT03731611
35 MRI Assessment of Placental Health Recruiting NCT02297724
36 The PREPPeD Study: "PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome" Recruiting NCT03100084
37 Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia Recruiting NCT02699437
38 Imaging Innovations for Placental Assessment in Response to Environmental Pollution Recruiting NCT02786420
39 Doppler Echocardiography Assessment of Cardiac Sparing Effect in Fetal Hypoxia Recruiting NCT03146507
40 Frequency of Performing Umbilical Artery Doppler in the Third Trimester in High Risk Pregnancy A Randomized Controlled Trial Recruiting NCT03584763
41 Effect of L-Arginine on Intrauterine Growth Restriction Fetuses Measured by Birth Weight: Randomized Controlled Trial Recruiting NCT03321292 L-arginine 1000 mg and Acetylesalicylic acid75mg;acetylsalicylic acid 75 mg
42 Preeclampsia Ratio (sFlt-1/PlGF) Evaluation for Clinical and Obstetrical Guidance Recruiting NCT03289611
43 Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation Recruiting NCT04093986
44 The Lupus prEGnAnCY Cohort: An International Prospective Cohort of Lupus Pregnancies Recruiting NCT03746028
45 Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE Active, not recruiting NCT01092949
46 Study of the Fetoplacental BOLD Effect in Pregnant Women Using Functional MRI Active, not recruiting NCT02238301
47 Oxygen for Category II Intrauterine Fetal Resuscitation: A Randomized, Noninferiority Trial Active, not recruiting NCT02741284 Room air;10L Oxygen by nonrebreather mask
48 LUMIERE on the PLACENTA : A Study on the Added Value of MRI Not yet recruiting NCT04166448
49 Effect of Maternal Iron Deficiency Anemia on Fetal Hemodynamics and Neonatal Outcome Not yet recruiting NCT04016922
50 Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities: a Randomized Clinical Trial Not yet recruiting NCT03996317

Search NIH Clinical Center for Placental Insufficiency

Cochrane evidence based reviews: placental insufficiency

Genetic Tests for Placental Insufficiency

Anatomical Context for Placental Insufficiency

MalaCards organs/tissues related to Placental Insufficiency:

40
Placenta, Heart, Brain, Testes, Lung, Fetal Brain, Endothelial

Publications for Placental Insufficiency

Articles related to Placental Insufficiency:

(show top 50) (show all 1772)
# Title Authors PMID Year
1
Reduced maternal serum concentrations of angiopoietin-2 in the first trimester precede intrauterine growth restriction associated with placental insufficiency. 54 61
17949380 2007
2
The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction. 61 54
12740423 2003
3
Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice. 54 61
12163461 2002
4
Placental expression of VEGF, PlGF and their receptors in a model of placental insufficiency-intrauterine growth restriction (PI-IUGR). 54 61
11945079 2002
5
Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. 54 61
11397868 2001
6
Chronic hypoxemia: effects on developing nitrergic and dopaminergic amacrine cells. 54 61
10359329 1999
7
[The importance of determining trophoblastic beta 1-glycoprotein (TBG) for the early diagnosis and prognosis of placental insufficiency in pregnant women with habitual abortion]. 61 54
1814220 1991
8
Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model. 61
31822711 2019
9
Effect of Curcumin on Growth Performance, Inflammation, Insulin level, and Lipid Metabolism in Weaned Piglets with IUGR. 61
31818040 2019
10
Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle. 61
31665811 2019
11
Early Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation. 61
30685870 2019
12
What's new in obstetric antiphospholipid syndrome. 61
31808896 2019
13
Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. 61
31751294 2019
14
Physiological development of the equine fetus during late gestation. 61
31721295 2019
15
Third stage of labor placental complications and placenta-associated syndromes. 61
31711332 2019
16
Maternal Iron Nutriture Modulates Placental Development in a Rat Model of Fetal Alcohol Spectrum Disorder. 61
31734307 2019
17
Distinctive patterns of placental lesions in pre-eclampsia vs small-for-gestational age and their association with fetoplacental Doppler. 61
31115105 2019
18
Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation. 61
31677200 2019
19
Doppler Indices and Notching Assessment of Uterine Artery Between the 19th and 22nd Week of Pregnancy in the Prediction of Pregnancy Outcome. 61
31662556 2019
20
Prenatal Testosterone Excess Disrupts Placental Function in a Sheep Model of Polycystic Ovary Syndrome. 61
31436841 2019
21
Does Fetal Pulmonary Venous Flow Impedance Increase in Pregnancies With Placental Insufficiency-Related Oligohydramnios in the Third Trimester? 61
31705722 2019
22
Predictors of perinatal outcome in early -onset fetal growth restriction: a study from an emerging economy country. 61
31674030 2019
23
Residential proximity to roadways and placental-associated stillbirth: a case-control study. 61
31587563 2019
24
Third-trimester Reference Ranges for Cerebroplacental Ratio and Pulsatility Index for Middle Cerebral Artery and Umbilical Artery in Normal-growth Singleton Fetuses in the Israeli Population. 61
31675306 2019
25
Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth. 61
31483497 2019
26
Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses. 61
31314546 2019
27
Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy. 61
31473512 2019
28
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development. 61
31625212 2019
29
DNA methylation of the Rtl1 promoter in the placentas with fetal growth restriction. 61
30679037 2019
30
Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses. 61
31653257 2019
31
Identification of the optimal growth charts for use in a preterm population: An Australian state-wide retrospective cohort study. 61
31584941 2019
32
Antiphospholipid Antibody Syndrome and Infertility. 61
31658490 2019
33
MicroRNAs in Uteroplacental Vascular Dysfunction. 61
31671866 2019
34
Exposure to placental insufficiency alters postnatal growth trajectory in extremely low birth weight infants. 61
31581967 2019
35
Sex-specific reference ranges of cerebroplacental and umbilicocerebral ratios: A longitudinal study. 61
31503378 2019
36
Disrupted placental serotonin synthetic pathway and increased placental serotonin: Potential implications in the pathogenesis of human fetal growth restriction. 61
31176514 2019
37
Developmental programming of adult haematopoiesis system. 61
31226498 2019
38
Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth restricted fetal sheep hindlimb. 61
31483682 2019
39
Cerebral-placental-uterine ratio as novel predictor of late fetal growth restriction: prospective cohort study. 61
30338593 2019
40
Heparin therapy in placental insufficiency: Systematic review and meta-analysis. 61
31519033 2019
41
Results of full postmortem examination in a cohort of clinically unexplained stillbirths: undetected fetal growth restriction and placental insufficiency are prevalent findings. 61
31266993 2019
42
The sFlt-1/PlGF ratio values within the <38, 38-85 and >85 brackets as compared to perinatal outcomes. 61
31339858 2019
43
In vitro fertilization is associated with the onset and progression of preeclampsia. 61
31675490 2019
44
Risk of ischemic placental disease is increased following in vitro fertilization with oocyte donation: a retrospective cohort study. 61
31359234 2019
45
Does Pentaerytrithyltetranitrate reduce fetal growth restriction in pregnancies complicated by uterine mal-perfusion? Study protocol of the PETN-study: a randomized controlled multicenter-trial. 61
31521118 2019
46
Managing antiphospholipid syndrome in pregnancy. 61
31477227 2019
47
Risk factors for perinatal arterial ischaemic stroke: a large case-control study. 61
31489622 2019
48
Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. 61
31318420 2019
49
Early psychosocial development of small for gestational age and intrauterine growth-restricted children: a systematic review. 61
30967654 2019
50
Cumulative Antenatal Risk and Kindergarten Readiness in Preterm-Born Preschoolers. 61
31418097 2019

Variations for Placental Insufficiency

Expression for Placental Insufficiency

Search GEO for disease gene expression data for Placental Insufficiency.

Pathways for Placental Insufficiency

Pathways related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 VEGFA TEK SOCS3 SERPINE1 PGF LEP
2
Show member pathways
13.82 VEGFA TEK PGF KDR IL6 HIF1A
3
Show member pathways
13.68 TEK SOCS3 LEP KDR IL6 FLT1
4
Show member pathways
13.5 VEGFA TEK SOCS3 PGF KDR IL6
5
Show member pathways
13.41 TEK PGF KDR IL6 FLT1 CXCL8
6
Show member pathways
13.35 VEGFA TEK SOCS3 IL6 HIF1A CXCL8
7
Show member pathways
13.31 VEGFA TEK SERPINE1 FGR F3 F2
8
Show member pathways
13.3 TEK PGF KDR IL6 FLT1 CXCL8
9
Show member pathways
13.04 PGF KDR IL6 HIF1A FLT1 F2
10
Show member pathways
12.97 VEGFA TEK PGF KDR IL6 FLT1
11 12.84 VEGFA PGF IL6 HIF1A F2 CXCL8
12 12.78 VEGFA TEK PGF KDR FLT1 ANGPT2
13
Show member pathways
12.75 VEGFA TEK PGF KDR FLT1 ANGPT2
14
Show member pathways
12.61 TEK SOCS3 IL6 F2 ANGPT2 ANGPT1
15
Show member pathways
12.38 TEK PGF KDR IL6 FLT1
17
Show member pathways
12.3 SOCS3 PGF KDR IL6 FLT1 CXCL8
18
Show member pathways
12.22 TEK F2 ANGPT2 ANGPT1
19
Show member pathways
12.22 SERPINE1 IL6 F3 CXCL8
20
Show member pathways
12.21 VEGFA SOCS3 SERPINE1 HIF1A
21 12.21 VEGFA TH IL6 HIF1A CXCL8
22 12.09 SOCS3 SERPINE1 LEP IL6 HIF1A
23 12.07 VEGFA KDR IL6 AFP
24 12.05 TEK SOCS3 KDR FLT1 FGR ANGPT2
25 12 VEGFA SOCS3 IL6 HIF1A CXCL8
26 11.89 VEGFA SERPINE1 IL6 F3 CXCL8
27
Show member pathways
11.82 VEGFA PGF KDR HIF1A FLT1
28 11.79 IL6 CXCL8 AFP
29 11.73 VEGFA SERPINE1 LEP HIF1A
30 11.7 VEGFA TEK IL6 FLT1 CXCL8 ANGPT1
31
Show member pathways
11.65 VEGFA IL6 CXCL8
32 11.63 TH SOCS3 IL6 CXCL8
33 11.59 VEGFA IL6 HIF1A CXCL8
34 11.58 TEK KDR HIF1A FLT1 F3 ANGPT2
35 11.54 SOCS3 LEP FGR
36 11.47 VEGFA KDR FLT1
37 11.34 VEGFA SERPINE1 KDR FLT1
38 11.29 VEGFA SERPINE1 HIF1A ANGPT2 ANGPT1
39
Show member pathways
11.26 VEGFA SOCS3 LEP HIF1A
40 11.26 VEGFA TEK SERPINE1 IL6 HIF1A FLT1
41 11.21 VEGFA FLT1 FGR
42 10.94 TEK PGF KDR IL6 FLT1 CXCL8
43
Show member pathways
10.87 VEGFA PGF KDR FLT1
44 10.81 VEGFA TEK KDR HIF1A FLT1 ANGPT1
45 10.64 VEGFA HIF1A

GO Terms for Placental Insufficiency

Cellular components related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 VEGFA SERPINE1 PGF PAPPA LEP IL6
2 extracellular region GO:0005576 9.53 VEGFA TEK SERPINE1 PGF PAPPA LEP

Biological processes related to Placental Insufficiency according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.23 VEGFA PGF KDR FLT1 F2 ANGPT2
2 cell differentiation GO:0030154 10.21 VEGFA PGF KDR HIF1A FLT1 FGR
3 negative regulation of apoptotic process GO:0043066 10.1 VEGFA TEK SOCS3 LEP KDR IL6
4 positive regulation of cell proliferation GO:0008284 10.06 VEGFA PGF MIR520A LEP KDR IL6
5 positive regulation of cell migration GO:0030335 10.03 VEGFA KDR FLT1 FGR F3
6 cytokine-mediated signaling pathway GO:0019221 10.02 VEGFA SOCS3 IL6 HIF1A F3 CXCL8
7 cellular protein metabolic process GO:0044267 10 PAPPA IL6 F2 AFP
8 leukocyte migration GO:0050900 9.99 TEK F2 ANGPT2 ANGPT1
9 positive regulation of protein phosphorylation GO:0001934 9.99 VEGFA TEK PGF KDR F2
10 positive regulation of protein kinase B signaling GO:0051897 9.98 TEK LEP F3 ANGPT1
11 protein autophosphorylation GO:0046777 9.97 TEK KDR FLT1 FGR
12 regulation of cell shape GO:0008360 9.96 VEGFA KDR FGR F2
13 peptidyl-tyrosine phosphorylation GO:0018108 9.96 TEK KDR FLT1 FGR
14 positive regulation of MAPK cascade GO:0043410 9.94 LEP KDR IL6 FLT1
15 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.92 TEK KDR FLT1 FGR ANGPT1
16 response to hypoxia GO:0001666 9.91 VEGFA TH TEK PGF LEP HIF1A
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 VEGFA SOCS3 LEP IL6
18 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 VEGFA IL6 ANGPT1
19 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.88 VEGFA PGF KDR FLT1
20 positive regulation of endothelial cell migration GO:0010595 9.86 VEGFA TEK KDR ANGPT1
21 positive chemotaxis GO:0050918 9.85 VEGFA PGF ANGPT1
22 positive regulation of blood vessel endothelial cell migration GO:0043536 9.84 VEGFA KDR HIF1A ANGPT1
23 response to activity GO:0014823 9.83 TH LEP ANGPT2
24 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.83 VEGFA KDR FLT1
25 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.82 TEK FLT1 FGR
26 positive regulation of JAK-STAT cascade GO:0046427 9.81 LEP IL6 F2
27 blood vessel morphogenesis GO:0048514 9.81 HIF1A FLT1 ANGPT2
28 negative regulation of endothelial cell apoptotic process GO:2000352 9.81 TEK SERPINE1 KDR ANGPT1
29 positive regulation of endothelial cell proliferation GO:0001938 9.8 VEGFA TEK PGF KDR HIF1A F3
30 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 TEK LEP KDR FLT1 FGR F2
31 positive regulation of focal adhesion assembly GO:0051894 9.79 VEGFA TEK KDR
32 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.79 VEGFA HIF1A FLT1
33 induction of positive chemotaxis GO:0050930 9.76 VEGFA PGF CXCL8
34 positive regulation of positive chemotaxis GO:0050927 9.74 VEGFA KDR F3
35 vascular endothelial growth factor signaling pathway GO:0038084 9.71 VEGFA PGF KDR FLT1
36 sexual reproduction GO:0019953 9.7 LEP AFP
37 negative regulation of fibrinolysis GO:0051918 9.7 SERPINE1 F2
38 negative regulation of lipid storage GO:0010888 9.7 LEP IL6
39 ovulation from ovarian follicle GO:0001542 9.69 LEP AFP
40 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.68 VEGFA HIF1A
41 positive regulation of mast cell chemotaxis GO:0060754 9.68 VEGFA PGF
42 regulation of endothelial cell proliferation GO:0001936 9.68 LEP ANGPT1
43 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.67 VEGFA KDR
44 glomerulus vasculature development GO:0072012 9.65 TEK ANGPT2 ANGPT1
45 positive regulation of angiogenesis GO:0045766 9.65 VEGFA TEK SERPINE1 PGF KDR HIF1A
46 sprouting angiogenesis GO:0002040 9.63 VEGFA TEK PGF KDR FLT1 ANGPT1
47 elastin metabolic process GO:0051541 9.62 LEP HIF1A
48 Tie signaling pathway GO:0048014 9.61 TEK ANGPT2 ANGPT1
49 angiogenesis GO:0001525 9.36 VEGFA TEK SERPINE1 PGF LEP KDR

Molecular functions related to Placental Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 VEGFA PGF IL6 F2
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.54 TEK KDR FLT1
3 vascular endothelial growth factor binding GO:0038085 9.43 KDR FLT1
4 vascular endothelial growth factor-activated receptor activity GO:0005021 9.4 KDR FLT1
5 growth factor binding GO:0019838 9.33 TEK KDR FLT1
6 vascular endothelial growth factor receptor binding GO:0005172 9.32 VEGFA PGF
7 protein tyrosine kinase activity GO:0004713 9.26 TEK KDR FLT1 FGR
8 signaling receptor binding GO:0005102 9.1 SERPINE1 LEP FGR F2 ANGPT2 ANGPT1

Sources for Placental Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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