PSST
MCID: PLC003
MIFTS: 45

Placental Site Trophoblastic Tumor (PSST)

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Placental Site Trophoblastic Tumor

MalaCards integrated aliases for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 12 58 15 17
Trophoblastic Tumor, Placental Site 44 70
Trophoblastic Tumor Placental Site 20 54
Placental-Site Gestational Trophoblastic Neoplasm 12
Placental Site Trophoblastic Tumour 12
Placenta Neoplasm 20
Deciduoma 70
Psst 58

Characteristics:

Orphanet epidemiological data:

58
placental site trophoblastic tumor
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3596
MeSH 44 D018245
NCIt 50 C3757
SNOMED-CT 67 75320001
MESH via Orphanet 45 D018245
ICD10 via Orphanet 33 D39.2
UMLS via Orphanet 71 C0206666
Orphanet 58 ORPHA99928
UMLS 70 C0206666 C0524541

Summaries for Placental Site Trophoblastic Tumor

Disease Ontology : 12 A choriocarcinoma that is characterized by low beta-hCG levels and arises from neoplastic transformation of intermediate trophoblastic cells.

MalaCards based summary : Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to hydatidiform mole, recurrent, 1 and gestational trophoblastic neoplasm. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Subunit Alpha), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Relaxin signaling pathway. The drugs Nitroglycerin and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and testis, and related phenotypes are spontaneous abortion and amenorrhea

Wikipedia : 73 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

Related Diseases for Placental Site Trophoblastic Tumor

Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 hydatidiform mole, recurrent, 1 31.2 INHA CGB5 CGB3
2 gestational trophoblastic neoplasm 31.1 LGALS1 CSH2 CSH1 CGB5 CGB3
3 teratoma 30.9 GPC3 CGB5 CGB3
4 ectopic pregnancy 30.7 VEGFA LGALS1 CGB5 CGB3
5 nonseminomatous germ cell tumor 30.5 ERBB2 CGB5
6 seminoma 30.5 INHA CGB5 CGB3
7 trophoblastic neoplasm 30.2 LNPEP LGALS1 INHA CSH2 CSH1 CGB5
8 endometrial adenocarcinoma 30.2 VEGFA ERBB2 EGFR
9 endodermal sinus tumor 30.0 SALL4 INHA GPC3 CGB5 CGB3
10 choriocarcinoma 29.9 LNPEP GPC3 CSH2 CSH1 CGB5 CGB3
11 testicular trophoblastic tumor 29.9 CSH2 CSH1
12 mature teratoma 29.9 SALL4 ERBB2
13 gestational choriocarcinoma 29.9 CSH2 CSH1
14 placenta praevia 29.9 CSH2 CSH1
15 epithelioid trophoblastic tumor 29.5 SALL4 LGALS1 INHA CSH2 CSH1 CGB3
16 pre-eclampsia 28.8 VEGFA LNPEP INHA CSH2 CSH1 CGB3
17 amenorrhea 10.8
18 rare tumor 10.6
19 nephrotic syndrome 10.6
20 germ cells tumors 10.4
21 leiomyoma 10.3
22 vaginal discharge 10.3
23 thrombotic microangiopathy 10.3
24 ovarian primitive germ cell tumor 10.3 SALL4 GPC3
25 ovarian endodermal sinus tumor 10.3 SALL4 GPC3
26 testicular malignant germ cell cancer 10.3 SALL4 GPC3
27 proteinuria, chronic benign 10.3
28 pneumothorax 10.3
29 leiomyosarcoma 10.3
30 glomerulonephritis 10.3
31 invasive mole 10.3
32 premenstrual tension 10.3
33 breast scirrhous carcinoma 10.2 ERBB2 EGFR
34 soft tissue sarcoma 10.2 VEGFA EGFR
35 breast metaplastic carcinoma 10.2 ERBB2 EGFR
36 submandibular gland cancer 10.2 ERBB2 EGFR
37 ovarian germ cell cancer 10.2 SALL4 GPC3
38 granulosa cell tumor of the ovary 10.2 INHA ERBB2
39 breast malignant phyllodes tumor 10.2 ERBB2 EGFR
40 progesterone-receptor negative breast cancer 10.2 ERBB2 EGFR
41 paronychia 10.2 ERBB2 EGFR
42 malignant teratoma 10.2 SALL4 GPC3 CGB5
43 apocrine adenocarcinoma 10.2 ERBB2 EGFR
44 biliary tract cancer 10.2 ERBB2 EGFR
45 ethmoid sinus adenocarcinoma 10.1 ERBB2 EGFR
46 hepatoid adenocarcinoma 10.1 SALL4 GPC3 EGFR
47 synchronous bilateral breast carcinoma 10.1 ERBB2 EGFR
48 cystic teratoma 10.1
49 embryonal carcinoma 10.1
50 peritonitis 10.1

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to Placental Site Trophoblastic Tumor

Symptoms & Phenotypes for Placental Site Trophoblastic Tumor

Human phenotypes related to Placental Site Trophoblastic Tumor:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 spontaneous abortion 58 31 hallmark (90%) Very frequent (99-80%) HP:0005268
2 amenorrhea 58 31 hallmark (90%) Very frequent (99-80%) HP:0000141
3 low maternal serum chorionic gonadotropin 58 31 hallmark (90%) Very frequent (99-80%) HP:0011434
4 metrorrhagia 58 31 hallmark (90%) Very frequent (99-80%) HP:0100608

MGI Mouse Phenotypes related to Placental Site Trophoblastic Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.8 EGFR ERBB2 GPC3 LGALS1 SALL4 VEGFA
2 digestive/alimentary MP:0005381 9.73 EGFR ERBB2 GPC3 INHA SALL4 VEGFA
3 limbs/digits/tail MP:0005371 9.63 EGFR EGR1 ERBB2 GPC3 SALL4 VEGFA
4 reproductive system MP:0005389 9.61 EGFR EGR1 ERBB2 GPC3 INHA LGALS1
5 respiratory system MP:0005388 9.1 EGFR EGR1 ERBB2 GPC3 LGALS1 VEGFA

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3 Angiogenesis Inhibitors Phase 2
4 Antibodies Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Immunoglobulins Phase 2
7 insulin
8 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2A Study of TRC105 (With Option to Add Bevacizumab) in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Terminated NCT02664961 Phase 2 TRC105;Bevacizumab
2 Problem Solving Skills Training For Parent Caregivers of Youth With Chronic Pain Completed NCT01496378
3 FL3X: An Adaptive Intervention to Improve Outcomes for Youth With Type 1 Diabetes Completed NCT01286350
4 Problem Solving Skills Training in Adult Cancer Survivors: Bright IDEAS-AC Active, not recruiting NCT03567850

Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Cochrane evidence based reviews: trophoblastic tumor, placental site

Genetic Tests for Placental Site Trophoblastic Tumor

Anatomical Context for Placental Site Trophoblastic Tumor

MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

40
Placenta, Uterus, Testis, Cervix, Adipocyte, Ovary, Lymph Node

Publications for Placental Site Trophoblastic Tumor

Articles related to Placental Site Trophoblastic Tumor:

(show top 50) (show all 381)
# Title Authors PMID Year
1
New discoveries on the biology and detection of human chorionic gonadotropin. 54 61
19171054 2009
2
Human chorionic gonadotropin free beta-subunit measurement as a marker of placental site trophoblastic tumors. 61 54
18773632 2008
3
Blood test for placental site trophoblastic tumor and nontrophoblastic malignancy for evaluating patients with low positive human chorionic gonadotropin results. 61 54
18720919 2008
4
Placental site trophoblastic tumor. 61 54
17701427 2008
5
Management of gestational trophoblastic disease and other cases with low serum levels of human chorionic gonadotropin. 54 61
17086809 2006
6
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells. 61 54
14691298 2003
7
Persistent low levels of human chorionic gonadotropin: A premalignant gestational trophoblastic disease. 54 61
12748494 2003
8
Persistent low-level "real" human chorionic gonadotropin: a clinical challenge and a therapeutic dilemma. 54 61
11972394 2002
9
Serum levels of macrophage colony-stimulating factor in trophoblastic disease. 61 54
11263936 2001
10
Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. 61 54
8396853 1993
11
"It's not lupus". A placental site trophoblastic tumor presenting as a lupus-like paraneoplastic syndrome. A grand round case. 61
33407043 2021
12
Fertility and pregnancy outcome in gestational trophoblastic disease. 61
33649007 2021
13
PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells. 61
33570788 2021
14
Total laparoscopic hysterectomy in combination with dilation and evacuation of an 18-week-sized uterus with gestational trophoblastic neoplasia: a novel treatment approach. 61
33197418 2021
15
Gestational trophoblastic neoplasia: Novelties and challenges. 61
33685753 2021
16
Directive clinique no 408 : Prise en charge des maladies gestationnelles trophoblastiques. 61
33384137 2021
17
Guideline No. 408: Management of Gestational Trophoblastic Diseases. 61
33384141 2021
18
Clinical presentation and diagnosis of Gestational Trophoblastic Disease. 61
33422446 2020
19
Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report. 61
33078754 2020
20
A Rare Case of Atypical Placental Site Nodule With an Emerging Intermediate Trophoblastic Tumor. 61
30829757 2020
21
Placental site trophoblastic tumor: Successful treatment of 13 cases. 61
32274412 2020
22
Whole transcriptome analysis of gestational trophoblastic neoplasms reveals altered PI3K signaling pathway in epithelioid trophoblastic tumor. 61
31954539 2020
23
Ovarian Intermediate Trophoblastic Tumors: Genotyping Defines a Distinct Category of Nongestational Tumors of Germ Cell Type. 61
31688005 2020
24
A review on management of gestational trophoblastic neoplasia. 61
32509606 2020
25
lnc003875/miR-363/EGR1 regulatory network in the carcinoma -associated fibroblasts controls the angiogenesis of human placental site trophoblastic tumor (PSTT). 61
31857113 2020
26
Recurrent Thyroid Storm Caused by a Complete Hydatidiform Mole in a Perimenopausal Woman. 61
33425402 2020
27
Placental site trophoblastic disease. 61
31699803 2020
28
Rare Case of Mixed Metastatic Placental Site Trophoblastic Tumor and Choriocarcinoma. 61
31206335 2019
29
Paraneoplastic nodular regenerative hyperplasia of the liver associated with placental site trophoblastic tumor. 61
31193692 2019
30
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy. 61
31047719 2019
31
Intermediate trophoblastic tumor: the clinical analysis of 62 cases and prognostic factors. 61
30607597 2019
32
[Testicular germ cell tumors: Histopathological and molecular features]. 61
30905378 2019
33
Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide. 61
30815369 2019
34
Management and prognostic factors of epithelioid trophoblastic tumors: Results from the International Society for the Study of Trophoblastic Diseases database. 61
30473257 2019
35
Diagnosis and Management of Mixed Gestational Trophoblastic Neoplasia: A Study of 16 Cases and a Review of the Literature. 61
31803628 2019
36
Differential expression of cyclin E, p63, and Ki-67 in gestational trophoblastic disease and its role in diagnosis and management: A prospective case-control study. 61
30706860 2019
37
A malignant placental site trophoblastic tumor of the uterus with multiple metastases: A case report of a rare tumor showing an aggressive behavior. 61
30706881 2019
38
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology. 61
30407075 2019
39
A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors. 61
31850188 2019
40
Management of placental site trophoblastic tumor: Two case reports. 61
30508960 2018
41
CARE-Placental site trophoblastic tumor presenting with thrombotic microangiopathy: A case report. 61
30412064 2018
42
Placenta Site Trophoblastic Tumor and Choriocarcinoma from Previous Cesarean Section Scar: Case Reports. 61
30046213 2018
43
Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea. 61
29780773 2018
44
Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature. 61
29395947 2018
45
Disappearance of a thrombotic microangiopathy-like glomerular lesion in a patient with a placental site trophoblastic tumor after hysterectomy. 61
30280075 2018
46
Two cases of epithelioid trophoblastic tumors in postmenopausal women. 61
28590345 2017
47
18F-FDG PET/CT Demonstrating Chorioadenoma Destruens After Evacuation of Complete Hydatidiform Mole. 61
28759528 2017
48
Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor. 61
28840513 2017
49
Placental site trophoblastic tumor with sole metastasis to breast: A case report. 61
28795129 2017
50
Salvage chemotherapy for gestational trophoblastic neoplasia: Utility or futility? 61
28473205 2017

Variations for Placental Site Trophoblastic Tumor

Expression for Placental Site Trophoblastic Tumor

Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.

Pathways for Placental Site Trophoblastic Tumor

GO Terms for Placental Site Trophoblastic Tumor

Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 VEGFA MIR363 LGALS1 INHA EGFR CSH2
2 extracellular region GO:0005576 9.32 VEGFA LNPEP LGALS1 INHA GPC3 EGFR

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.95 VEGFA SALL4 ERBB2 EGR1 EGFR CGB5
2 cell-cell signaling GO:0007267 9.62 LNPEP INHA CGB5 CGB3
3 lung development GO:0030324 9.61 VEGFA GPC3 EGFR
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 VEGFA CSH2 CSH1
5 animal organ development GO:0048513 9.52 CSH2 CSH1
6 female gamete generation GO:0007292 9.51 CGB5 CGB3
7 peptide hormone processing GO:0016486 9.49 CGB5 CGB3
8 growth hormone receptor signaling pathway GO:0060396 9.48 CSH2 CSH1
9 positive regulation of growth GO:0045927 9.46 CSH2 CSH1
10 positive regulation of epithelial cell proliferation GO:0050679 9.43 VEGFA ERBB2 EGFR
11 signal transduction GO:0007165 9.28 VEGFA LNPEP INHA ERBB2 EGFR CSH2
12 negative regulation of ERBB signaling pathway GO:1901185 9.16 ERBB2 EGFR
13 positive regulation of MAP kinase activity GO:0043406 9.13 VEGFA ERBB2 EGFR

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 VEGFA INHA CSH2 CSH1
2 growth hormone receptor binding GO:0005131 9.16 CSH2 CSH1
3 hormone activity GO:0005179 9.02 INHA CSH2 CSH1 CGB5 CGB3

Sources for Placental Site Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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