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PSST
MCID: PLC003
MIFTS: 48

Placental Site Trophoblastic Tumor (PSST)

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Placental Site Trophoblastic Tumor

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MalaCards integrated aliases for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 12 59 15
Trophoblastic Tumor, Placental Site 44 73
Trophoblastic Tumor Placental Site 53 55
Placental-Site Gestational Trophoblastic Neoplasm 12
Placenta Neoplasm 53
Deciduoma 73
Psst 59

Characteristics:

Orphanet epidemiological data:

59
placental site trophoblastic tumor
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34 33
Orphanet: 59  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3596
MeSH 44 D018245
NCIt 50 C3757
SNOMED-CT 68 75320001
Orphanet 59 ORPHA99928
MESH via Orphanet 45 D018245
ICD10 via Orphanet 34 D39.2
UMLS via Orphanet 74 C0206666
ICD10 33 C58
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Summaries for Placental Site Trophoblastic Tumor

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Disease Ontology : 12 A choriocarcinoma that is characterized by low beta-hCG levels and arises from neoplastic transformation of intermediate trophoblastic cells.

MalaCards based summary : Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to trophoblastic neoplasm and ectopic pregnancy. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Subunit Alpha), and among its related pathways/superpathways are Peptide hormone metabolism and Bladder cancer. The drugs Levoleucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related phenotypes are metrorrhagia and spontaneous abortion

Wikipedia : 76 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

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Related Diseases for Placental Site Trophoblastic Tumor

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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 trophoblastic neoplasm 31.4 CSH1 INHA LNPEP
2 ectopic pregnancy 30.3 CGB3 CGB5 VEGFA
3 placenta accreta 30.3 CGB3 EGFR
4 choriocarcinoma 30.2 CGB3 CGB5 CSH1 LNPEP
5 epithelioid trophoblastic tumor 30.1 CGB3 CSH1 INHA SALL4
6 gestational trophoblastic tumor 11.9
7 teratoma 10.3
8 leigh syndrome 10.2
9 gestational trophoblastic neoplasm 10.2
10 leiomyoma 10.2
11 germ cells tumors 10.2
12 hydatidiform mole, recurrent, 1 10.2 CGB3 CGB5
13 endodermal sinus tumor 10.1 CGB3 SALL4
14 premenstrual tension 10.1
15 soft tissue sarcoma 10.0 EGFR VEGFA
16 primary peritoneal carcinoma 10.0 EGFR VEGFA
17 geographic tongue 10.0 EGFR VEGFA
18 breast carcinoma in situ 10.0 EGFR VEGFA
19 suppressor of tumorigenicity 3 10.0
20 testicular germ cell tumor 10.0
21 testicular germ cell tumor 1 10.0
22 alopecia 10.0
23 arteriovenous fistula 10.0
24 nephrotic syndrome 10.0
25 amenorrhea 10.0
26 pneumothorax 10.0
27 infertility 10.0
28 ovarian germ cell teratoma 10.0
29 viral infectious disease 10.0
30 placental abruption 10.0
31 alopecia areata 10.0
32 nonseminomatous germ cell tumor 10.0
33 precocious puberty 10.0
34 invasive mole 10.0
35 testicular cancer 10.0 CGB3 CGB5
36 pharynx cancer 10.0 EGFR VEGFA
37 supratentorial cancer 10.0 EGFR VEGFA
38 cerebrum cancer 10.0 EGFR VEGFA
39 grade iii astrocytoma 10.0 EGFR VEGFA
40 central nervous system cancer 10.0 EGFR VEGFA
41 hemangioblastoma 10.0 INHA VEGFA
42 seminoma 10.0 CGB3 CGB5 INHA
43 nervous system cancer 10.0 EGFR VEGFA
44 colonic disease 10.0 EGFR VEGFA
45 colorectal adenocarcinoma 10.0 EGFR VEGFA
46 placenta disease 10.0 CGB3 CGB5 CSH1
47 uterine anomalies 10.0 CSH1 VEGFA
48 laryngeal squamous cell carcinoma 10.0 EGFR VEGFA
49 stomach disease 9.9 EGFR VEGFA
50 von hippel-lindau syndrome 9.9 INHA VEGFA

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to Placental Site Trophoblastic Tumor
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Symptoms & Phenotypes for Placental Site Trophoblastic Tumor

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Human phenotypes related to Placental Site Trophoblastic Tumor:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 metrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100608
2 spontaneous abortion 59 32 hallmark (90%) Very frequent (99-80%) HP:0005268
3 amenorrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0000141
4 low maternal serum chorionic gonadotropin 59 32 hallmark (90%) Very frequent (99-80%) HP:0011434
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Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
2
Methotrexate Approved Phase 2, Phase 3 59-05-2, 1959-05-2 126941
3
leucovorin Approved Phase 2, Phase 3,Phase 3 58-05-9 6006 143
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
5 Immunologic Factors Phase 2, Phase 3
6 Immunosuppressive Agents Phase 2, Phase 3
7 Vitamin B9 Phase 2, Phase 3
8 Antimetabolites, Antineoplastic Phase 2, Phase 3
9 Antirheumatic Agents Phase 2, Phase 3
10 Antimetabolites Phase 2, Phase 3
11 Vitamin B Complex Phase 2, Phase 3
12 Protective Agents Phase 2, Phase 3
13 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
14 Folic Acid Antagonists Phase 2, Phase 3
15 Micronutrients Phase 2, Phase 3
16 Vitamins Phase 2, Phase 3
17 Folate Phase 2, Phase 3
18 Dermatologic Agents Phase 2, Phase 3
19 Hematinics Phase 2, Phase 3
20 Trace Elements Phase 2, Phase 3
21 Antidotes Phase 2, Phase 3
22
Nivolumab Approved Phase 2 946414-94-4
23
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
24
Bevacizumab Approved, Investigational Phase 2 216974-75-3
25 Immunoglobulins Phase 2
26 Antibodies, Monoclonal Phase 2
27 Antibodies Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30 Chorionic Gonadotropin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
2 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
4 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Terminated NCT02664961 Phase 2 TRC105;Bevacizumab
5 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177
6 The French National Reference Centre of GTD Recruiting NCT02892877
7 Chemoresistance of Trophoblastic Tumors Not yet recruiting NCT03488901

Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Cochrane evidence based reviews: trophoblastic tumor, placental site

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Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

41
Placenta, Uterus, Lung, Ovary, Colon, Tongue, Thyroid
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Publications for Placental Site Trophoblastic Tumor

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Articles related to Placental Site Trophoblastic Tumor:

(show top 50) (show all 180)
# Title Authors Year
1
Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea. ( 29780773 )
2018
2
Disappearance of a thrombotic microangiopathy-like glomerular lesion in a patient with a placental site trophoblastic tumor after hysterectomy. ( 30280075 )
2018
3
CARE-Placental site trophoblastic tumor presenting with thrombotic microangiopathy: A case report. ( 30412064 )
2018
4
Management of placental site trophoblastic tumor: Two case reports. ( 30508960 )
2018
5
Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature. ( 29395947 )
2017
6
Presentation of Placental Site Trophoblastic Tumor with Amenorrhea. ( 28401076 )
2017
7
Placental site trophoblastic tumor in early stage: a case report. ( 29693898 )
2017
8
Placental site trophoblastic tumor with sole metastasis to breast: A case report. ( 28795129 )
2017
9
Postoperative chemotherapy on placental site trophoblastic tumor in early stage: analysis of 60 cases. ( 29693886 )
2017
10
Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor. ( 28840513 )
2017
11
A case of placental site trophoblastic tumor complicating nephrotic syndrome in which hysteroscopic biopsy did not yield a definitive diagnosis. ( 30254879 )
2017
12
Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina. ( 27513078 )
2016
13
Diagnosis and management of a rare case with placental site trophoblastic tumor. ( 27751424 )
2016
14
Placental site trophoblastic tumor: A review of 108 cases and their implications for prognosis and treatment. ( 27168005 )
2016
15
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. ( 27068524 )
2016
16
Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report. ( 27679689 )
2016
17
Placental Site Trophoblastic Tumor: A Distinct Entity of Gestational Trophoblastic Disease Experience from a Tertiary Referral Center in Hong Kong. ( 30408381 )
2016
18
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. ( 25908040 )
2015
19
Placental-site trophoblastic tumor and fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography. ( 26574698 )
2015
20
Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China. ( 25572983 )
2015
21
Placental site trophoblastic tumor: A case report and literature review. ( 26361566 )
2015
22
Placental site trophoblastic tumor: report of a tertiary center experience. ( 26775357 )
2015
23
Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation. ( 26597227 )
2015
24
Placental site trophoblastic tumor presented with vaginal metastasis. ( 25932270 )
2015
25
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. ( 26261623 )
2015
26
Placental site trophoblastic tumor: a case report and review of the literature. ( 26622924 )
2015
27
Attempted conservative management of a placental site trophoblastic tumor: a case report. ( 25314886 )
2014
28
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. ( 24944882 )
2014
29
Placental site trophoblastic tumor: Immunohistochemistry algorithm key to diagnosis and review of literature. ( 24624322 )
2014
30
Placental site trophoblastic tumor: a case report and review of the literature. ( 25593955 )
2014
31
Placental site trophoblastic tumor on endometrial polyp: a case report. ( 24654471 )
2014
32
Exaggerated placental site/placental site trophoblastic tumor: an underestimated risk factor for emergency peripartum hysterectomy. ( 25551954 )
2014
33
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. ( 23274560 )
2013
34
Placental site trophoblastic tumor with metastasis - A case report. ( 24532939 )
2013
35
Unsuccessful planned conservative resection of placental site trophoblastic tumor. ( 23344410 )
2013
36
Long-term outcome of placental site trophoblastic tumor in The Netherlands. ( 23763007 )
2013
37
Sonographic characteristics of placental site trophoblastic tumor. ( 22807194 )
2013
38
Diagnosis and treatment of placental site trophoblastic tumor. ( 23826431 )
2013
39
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. ( 24371716 )
2013
40
Placental site trophoblastic tumor in the pelvic wall: a case report and review of the literature. ( 24152517 )
2013
41
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. ( 23688193 )
2013
42
Placental site trophoblastic tumor, report of a case with unusual presentation. ( 23478075 )
2013
43
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. ( 23040933 )
2012
44
Placental Site Trophoblastic Tumor with lung metastases as cause of death in a young patient: a case report. ( 22027660 )
2011
45
Clinical features of 17 cases of placental site trophoblastic tumor. ( 21862010 )
2011
46
Kidney involvement in a patient affected by placental site trophoblastic tumor. ( 21257242 )
2011
47
Two cases of placental site trophoblastic tumor. ( 22030056 )
2011
48
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review. ( 21061810 )
2010
49
Placental site trophoblastic tumor--a challenging, rare entity. ( 21199764 )
2010
50
Expression of glypican 3 in placental site trophoblastic tumor. ( 20868507 )
2010
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Variations for Placental Site Trophoblastic Tumor

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Expression for Placental Site Trophoblastic Tumor

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Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.
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Pathways for Placental Site Trophoblastic Tumor

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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide hormone metabolism 66
Show member pathways
 11.39 CGB3 CGB5 INHA
2
Bladder cancer 37 1
11.27 EGFR VEGFA
3
Transcription Ligand-dependent activation of the ESR1/SP pathway 22
Show member pathways
 11.21 EGFR VEGFA
4
Aryl Hydrocarbon Receptor 1
11 EGFR VEGFA
5
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 10.89 CGB3 CGB5 EGFR VEGFA
6
Signaling events mediated by TCPTP 1
Show member pathways
 10.88 EGFR VEGFA
7
Vemurafenib Pathway, Pharmacodynamics 61
10.78 EGFR VEGFA
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GO Terms for Placental Site Trophoblastic Tumor

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Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CGB3 CGB5 CSH1 EGFR INHA VEGFA
2 extracellular region GO:0005576 9.17 CGB3 CGB5 CSH1 EGFR INHA LNPEP

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 CSH1 VEGFA
2 positive regulation of epithelial cell proliferation GO:0050679 9.46 EGFR VEGFA
3 positive regulation of MAP kinase activity GO:0043406 9.43 EGFR VEGFA
4 SMAD protein signal transduction GO:0060395 9.4 INHA LNPEP
5 hormone-mediated signaling pathway GO:0009755 9.37 CGB3 CGB5
6 ovarian follicle development GO:0001541 9.32 INHA VEGFA
7 peptide hormone processing GO:0016486 9.26 CGB3 CGB5
8 cell-cell signaling GO:0007267 9.26 CGB3 CGB5 INHA LNPEP
9 female gamete generation GO:0007292 9.16 CGB3 CGB5
10 regulation of signaling receptor activity GO:0010469 9.02 CGB3 CGB5 CSH1 INHA VEGFA

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 CSH1 INHA VEGFA
2 hormone activity GO:0005179 8.8 CGB3 CSH1 INHA
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Sources for Placental Site Trophoblastic Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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