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MCID: PLC003
MIFTS: 45

Placental Site Trophoblastic Tumor

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Placental Site Trophoblastic Tumor

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MalaCards integrated aliases for Placental Site Trophoblastic Tumor:

Name: Placental Site Trophoblastic Tumor 12 59 15
Trophoblastic Tumor, Placental Site 44 73
Trophoblastic Tumor Placental Site 53 55
Placental-Site Gestational Trophoblastic Neoplasm 12
Placenta Neoplasm 53
Deciduoma 73
Psst 59

Characteristics:

Orphanet epidemiological data:

59
placental site trophoblastic tumor
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34 33
Orphanet: 59  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3596
MeSH 44 D018245
NCIt 50 C3757
SNOMED-CT 68 237252008 75320001
Orphanet 59 ORPHA99928
MESH via Orphanet 45 D018245
ICD10 via Orphanet 34 D39.2
UMLS via Orphanet 74 C0206666
ICD10 33 C58
Sources

Summaries for Placental Site Trophoblastic Tumor

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MalaCards based summary : Placental Site Trophoblastic Tumor, also known as trophoblastic tumor, placental site, is related to trophoblastic neoplasm and ectopic pregnancy. An important gene associated with Placental Site Trophoblastic Tumor is INHA (Inhibin Subunit Alpha), and among its related pathways/superpathways are Peptide hormone metabolism and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Levoleucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and lung, and related phenotypes are amenorrhea and spontaneous abortion

Wikipedia : 76 Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to... more...

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Related Diseases for Placental Site Trophoblastic Tumor

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Diseases related to Placental Site Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 trophoblastic neoplasm 30.2 CSH1 INHA LNPEP
2 ectopic pregnancy 30.2 CGB3 CGB5
3 epithelioid trophoblastic tumor 28.9 CGB3 CSH1 INHA SALL4
4 choriocarcinoma 27.6 CGB3 CGB5 CSH1 GPC3 LNPEP
5 gestational trophoblastic tumor 11.8
6 hydatidiform mole, recurrent, 1 10.3 CGB3 CGB5
7 teratoma 10.1
8 germ cells tumors 10.1
9 endodermal sinus tumor 10.1 CGB3 SALL4
10 leigh syndrome 10.1
11 gestational trophoblastic neoplasm 10.1
12 leiomyoma 10.1
13 vaginitis 10.1
14 cervicitis 10.1
15 placenta disease 10.0 CGB3 CSH1
16 testicular cancer 10.0 CGB3 CGB5
17 robinow syndrome, autosomal recessive 10.0 INHA SALL4
18 suppressor of tumorigenicity 3 9.9
19 testicular germ cell tumor 9.9
20 testicular germ cell tumor 1 9.9
21 alopecia 9.9
22 arteriovenous fistula 9.9
23 amenorrhea 9.9
24 pneumothorax 9.9
25 placenta accreta 9.9
26 infertility 9.9
27 ovarian germ cell teratoma 9.9
28 placental abruption 9.9
29 alopecia areata 9.9
30 nonseminomatous germ cell tumor 9.9
31 precocious puberty 9.9
32 mixed germ cell tumor 9.9
33 invasive mole 9.9
34 ovarian endodermal sinus tumor 9.9 GPC3 SALL4
35 seminoma 9.8 CGB3 CGB5 INHA
36 ovarian primitive germ cell tumor 9.8 GPC3 SALL4
37 testicular yolk sac tumor 9.7 GPC3 SALL4
38 gastrointestinal system cancer 9.4 EGFR GPC3

Graphical network of the top 20 diseases related to Placental Site Trophoblastic Tumor:



Diseases related to Placental Site Trophoblastic Tumor
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Symptoms & Phenotypes for Placental Site Trophoblastic Tumor

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Human phenotypes related to Placental Site Trophoblastic Tumor:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 amenorrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0000141
2 spontaneous abortion 59 32 hallmark (90%) Very frequent (99-80%) HP:0005268
3 low maternal serum chorionic gonadotropin 59 32 hallmark (90%) Very frequent (99-80%) HP:0011434
4 metrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100608
Sources

Drugs & Therapeutics for Placental Site Trophoblastic Tumor

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Drugs for Placental Site Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
2
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
4
leucovorin Approved, Nutraceutical Phase 2, Phase 3,Phase 3 58-05-9 143 6006
5 Antidotes Phase 2, Phase 3
6 Antimetabolites Phase 2, Phase 3
7 Antimetabolites, Antineoplastic Phase 2, Phase 3
8 Antirheumatic Agents Phase 2, Phase 3
9 Dermatologic Agents Phase 2, Phase 3
10 Folic Acid Antagonists Phase 2, Phase 3
11 Hematinics Phase 2, Phase 3
12 Immunosuppressive Agents Phase 2, Phase 3
13 Micronutrients Phase 2, Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
15 Protective Agents Phase 2, Phase 3
16 Trace Elements Phase 2, Phase 3
17 Vitamin B Complex Phase 2, Phase 3
18 Vitamins Phase 2, Phase 3
19 Folate Nutraceutical Phase 2, Phase 3
20 Vitamin B9 Nutraceutical Phase 2, Phase 3
21
Bevacizumab Approved, Investigational Phase 2 216974-75-3
22
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
23
nivolumab Approved Phase 2 946414-94-4
24 Angiogenesis Inhibitors Phase 2
25 Angiogenesis Modulating Agents Phase 2
26 Antibodies Phase 2
27 Antibodies, Monoclonal Phase 2
28 Immunoglobulins Phase 2
29 Chorionic Gonadotropin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
2 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
3 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
4 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
5 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177
6 The French National Reference Centre of GTD Recruiting NCT02892877
7 Chemoresistance of Trophoblastic Tumors Not yet recruiting NCT03488901

Search NIH Clinical Center for Placental Site Trophoblastic Tumor

Cochrane evidence based reviews: trophoblastic tumor, placental site

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Genetic Tests for Placental Site Trophoblastic Tumor

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Anatomical Context for Placental Site Trophoblastic Tumor

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MalaCards organs/tissues related to Placental Site Trophoblastic Tumor:

41
Placenta, Uterus, Lung, Testis, Ovary, Brain, Cervix
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Publications for Placental Site Trophoblastic Tumor

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Articles related to Placental Site Trophoblastic Tumor:

(show top 50) (show all 174)
# Title Authors Year
1
Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea. ( 29780773 )
2018
2
Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature. ( 29395947 )
2017
3
Presentation of Placental Site Trophoblastic Tumor with Amenorrhea. ( 28401076 )
2017
4
Placental site trophoblastic tumor in early stage: a case report. ( 29693898 )
2017
5
Placental site trophoblastic tumor with sole metastasis to breast: A case report. ( 28795129 )
2017
6
Postoperative chemotherapy on placental site trophoblastic tumor in early stage: analysis of 60 cases. ( 29693886 )
2017
7
Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor. ( 28840513 )
2017
8
Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina. ( 27513078 )
2016
9
Diagnosis and management of a rare case with placental site trophoblastic tumor. ( 27751424 )
2016
10
Placental site trophoblastic tumor: A review of 108 cases and their implications for prognosis and treatment. ( 27168005 )
2016
11
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. ( 27068524 )
2016
12
Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report. ( 27679689 )
2016
13
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. ( 25908040 )
2015
14
Placental-site trophoblastic tumor and fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography. ( 26574698 )
2015
15
Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China. ( 25572983 )
2015
16
Placental site trophoblastic tumor: A case report and literature review. ( 26361566 )
2015
17
Placental site trophoblastic tumor: report of a tertiary center experience. ( 26775357 )
2015
18
Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation. ( 26597227 )
2015
19
Placental site trophoblastic tumor presented with vaginal metastasis. ( 25932270 )
2015
20
Placental site trophoblastic tumor: a case report and review of the literature. ( 26622924 )
2015
21
Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. ( 26261623 )
2015
22
Attempted conservative management of a placental site trophoblastic tumor: a case report. ( 25314886 )
2014
23
Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. ( 24944882 )
2014
24
Placental site trophoblastic tumor: Immunohistochemistry algorithm key to diagnosis and review of literature. ( 24624322 )
2014
25
Placental site trophoblastic tumor: a case report and review of the literature. ( 25593955 )
2014
26
Placental site trophoblastic tumor on endometrial polyp: a case report. ( 24654471 )
2014
27
Exaggerated placental site/placental site trophoblastic tumor: an underestimated risk factor for emergency peripartum hysterectomy. ( 25551954 )
2014
28
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. ( 23274560 )
2013
29
Placental site trophoblastic tumor with metastasis - A case report. ( 24532939 )
2013
30
Unsuccessful planned conservative resection of placental site trophoblastic tumor. ( 23344410 )
2013
31
Long-term outcome of placental site trophoblastic tumor in The Netherlands. ( 23763007 )
2013
32
Sonographic characteristics of placental site trophoblastic tumor. ( 22807194 )
2013
33
Diagnosis and treatment of placental site trophoblastic tumor. ( 23826431 )
2013
34
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. ( 24371716 )
2013
35
Placental site trophoblastic tumor in the pelvic wall: a case report and review of the literature. ( 24152517 )
2013
36
Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. ( 23688193 )
2013
37
Placental site trophoblastic tumor, report of a case with unusual presentation. ( 23478075 )
2013
38
Exaggerated placenta site in placenta previa: an imaging differential diagnosis of placenta accreta, placental site trophoblastic tumor and molar pregnancy. ( 23040933 )
2012
39
Placental Site Trophoblastic Tumor with lung metastases as cause of death in a young patient: a case report. ( 22027660 )
2011
40
Clinical features of 17 cases of placental site trophoblastic tumor. ( 21862010 )
2011
41
Kidney involvement in a patient affected by placental site trophoblastic tumor. ( 21257242 )
2011
42
Two cases of placental site trophoblastic tumor. ( 22030056 )
2011
43
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review. ( 21061810 )
2010
44
Placental site trophoblastic tumor--a challenging, rare entity. ( 21199764 )
2010
45
Expression of glypican 3 in placental site trophoblastic tumor. ( 20868507 )
2010
46
Placental site trophoblastic tumor presenting as a friable cervical mass. ( 21061804 )
2010
47
Placental site trophoblastic tumor with unusual presentation in the uterine cervix. ( 19819607 )
2010
48
Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. ( 20381116 )
2010
49
Placental site trophoblastic tumor: lymphatic spread and possible target markers. ( 19910023 )
2010
50
Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty. ( 18671454 )
2009
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Variations for Placental Site Trophoblastic Tumor

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Expression for Placental Site Trophoblastic Tumor

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Search GEO for disease gene expression data for Placental Site Trophoblastic Tumor.
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Pathways for Placental Site Trophoblastic Tumor

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Pathways related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide hormone metabolism 66
Show member pathways
 11.39 CGB3 CGB5 INHA
2
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 10.77 CGB3 CGB5 EGFR
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GO Terms for Placental Site Trophoblastic Tumor

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Cellular components related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CGB3 CGB5 CSH1 EGFR GPC3 INHA

Biological processes related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.63 CGB3 CGB5 EGFR INHA LNPEP SALL4
2 lung development GO:0030324 9.4 EGFR GPC3
3 SMAD protein signal transduction GO:0060395 9.37 INHA LNPEP
4 peptide hormone processing GO:0016486 9.32 CGB3 CGB5
5 female gamete generation GO:0007292 9.26 CGB3 CGB5
6 regulation of signaling receptor activity GO:0010469 9.26 CGB3 CGB5 CSH1 INHA
7 cell-cell signaling GO:0007267 8.92 CGB3 CGB5 INHA LNPEP

Molecular functions related to Placental Site Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CGB3 CSH1 INHA
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Sources for Placental Site Trophoblastic Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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